Abstract

Intraoperative 5- aminolevulinic acid induced-Protoporphyrin IX (PpIX) fluorescence guidance enables maximum safe resection of glioblastomas by providing surgeons with real-time tumor optical contrast. However, visual assessment of PpIX fluorescence is subjective and limited by the distorting effects of light attenuation and tissue autofluorescence. We have previously shown that non-invasive point measurements of absolute PpIX concentration identifies residual tumor that is otherwise non-detectable. Here, we extend this approach to wide-field quantitative fluorescence imaging by implementing spatial frequency domain imaging to recover tissue optical properties across the field-of-view in phantoms and ex vivo tissue.

© 2015 Optical Society of America

Full Article  |  PDF Article
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  4. P. A. Valdés, A. Kim, F. Leblond, O. M. Conde, B. T. Harris, K. D. Paulsen, B. C. Wilson, and D. W. Roberts, “Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery,” J. Biomed. Opt. 16(11), 116007 (2011).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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  20. L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

2015 (2)

M. Sibai, I. Veilleux, J. T. Eliott, F. Leblond, D. W. Roberts, and B. C. Wilson, “Quantitative fluorescence imaging enabled by spatial frequency domain optical-property mapping in the sub-diffusive regime for surgical guidance,” Proc. SPIE 93110, 93110C (2015).

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

2014 (1)

2013 (5)

M. Mesradi, A. Genoux, V. Cuplov, D. Abi Haidar, S. Jan, I. Buvat, and F. Pain, “Experimental and analytical comparative study of optical coefficient of fresh and frozen rat tissues,” J. Biomed. Opt. 18(11), 117010 (2013).
[Crossref] [PubMed]

P. A. Valdés, V. L. Jacobs, B. C. Wilson, F. Leblond, D. W. Roberts, and K. D. Paulsen, “System and methods for wide-field quantitative fluorescence imaging during neurosurgery,” Opt. Lett. 38(15), 2786–2788 (2013).
[Crossref] [PubMed]

A. J. Lin, A. Ponticorvo, S. D. Konecky, H. Cui, T. B. Rice, B. Choi, A. J. Durkin, and B. J. Tromberg, “Visible spatial frequency domain imaging with a digital light microprojector,” J. Biomed. Opt. 18(9), 096007 (2013).
[Crossref] [PubMed]

B. Yang, M. Sharma, and J. W. Tunnell, “Attenuation-corrected fluorescence extraction for image-guided surgery in spatial frequency domain,” J. Biomed. Opt. 18(8), 080503 (2013).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

2012 (2)

M. J. Colditz and R. L. Jeffree, “Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies,” J. Clin. Neurosci. 19(11), 1471–1474 (2012).
[Crossref] [PubMed]

M. J. Colditz, K. Leyen, and R. L. Jeffree, “Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: Theoretical, biochemical and practical aspects,” J. Clin. Neurosci. 19(12), 1611–1616 (2012).
[Crossref] [PubMed]

2011 (3)

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

P. A. Valdés, A. Kim, F. Leblond, O. M. Conde, B. T. Harris, K. D. Paulsen, B. C. Wilson, and D. W. Roberts, “Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery,” J. Biomed. Opt. 16(11), 116007 (2011).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

2010 (2)

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

2009 (2)

D. S. Kepshire, S. L. Gibbs-Strauss, J. A. O’Hara, M. Hutchins, N. Mincu, F. Leblond, M. Khayat, H. Dehghani, S. Srinivasan, and B. W. Pogue, “Imaging of glioma tumor with endogenous fluorescence tomography,” J. Biomed. Opt. 14(3), 030501 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

2008 (1)

2006 (1)

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

2004 (1)

L. Marcu, J. A. Jo, P. V. Butte, W. H. Yong, B. K. Pikul, K. L. Black, and R. C. Thompson, “Fluorescence lifetime spectroscopy of glioblastoma multiforme,” Photochem. Photobiol. 80(1), 98–103 (2004).
[Crossref] [PubMed]

Abi Haidar, D.

M. Mesradi, A. Genoux, V. Cuplov, D. Abi Haidar, S. Jan, I. Buvat, and F. Pain, “Experimental and analytical comparative study of optical coefficient of fresh and frozen rat tissues,” J. Biomed. Opt. 18(11), 117010 (2013).
[Crossref] [PubMed]

Andersson-Engels, S.

Angulo-Rodrigues, L. M.

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

Ayers, F. R.

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Baribeau, F.

Barth, R. J.

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

Bénazech-Lavoué, M.

Bérubé-Lauzière, Y.

Bevilacqua, F.

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Black, K. L.

L. Marcu, J. A. Jo, P. V. Butte, W. H. Yong, B. K. Pikul, K. L. Black, and R. C. Thompson, “Fluorescence lifetime spectroscopy of glioblastoma multiforme,” Photochem. Photobiol. 80(1), 98–103 (2004).
[Crossref] [PubMed]

Bodnar, O.

Botwicz, M.

Bouchard, J. P.

Butte, P. V.

L. Marcu, J. A. Jo, P. V. Butte, W. H. Yong, B. K. Pikul, K. L. Black, and R. C. Thompson, “Fluorescence lifetime spectroscopy of glioblastoma multiforme,” Photochem. Photobiol. 80(1), 98–103 (2004).
[Crossref] [PubMed]

Buvat, I.

M. Mesradi, A. Genoux, V. Cuplov, D. Abi Haidar, S. Jan, I. Buvat, and F. Pain, “Experimental and analytical comparative study of optical coefficient of fresh and frozen rat tissues,” J. Biomed. Opt. 18(11), 117010 (2013).
[Crossref] [PubMed]

Choi, B.

A. J. Lin, A. Ponticorvo, S. D. Konecky, H. Cui, T. B. Rice, B. Choi, A. J. Durkin, and B. J. Tromberg, “Visible spatial frequency domain imaging with a digital light microprojector,” J. Biomed. Opt. 18(9), 096007 (2013).
[Crossref] [PubMed]

Colditz, M. J.

M. J. Colditz and R. L. Jeffree, “Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies,” J. Clin. Neurosci. 19(11), 1471–1474 (2012).
[Crossref] [PubMed]

M. J. Colditz, K. Leyen, and R. L. Jeffree, “Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: Theoretical, biochemical and practical aspects,” J. Clin. Neurosci. 19(12), 1611–1616 (2012).
[Crossref] [PubMed]

Conde, O. M.

P. A. Valdés, A. Kim, F. Leblond, O. M. Conde, B. T. Harris, K. D. Paulsen, B. C. Wilson, and D. W. Roberts, “Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery,” J. Biomed. Opt. 16(11), 116007 (2011).
[Crossref] [PubMed]

Cubeddu, R.

Cuccia, D.

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

Cuccia, D. J.

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Cui, H.

A. J. Lin, A. Ponticorvo, S. D. Konecky, H. Cui, T. B. Rice, B. Choi, A. J. Durkin, and B. J. Tromberg, “Visible spatial frequency domain imaging with a digital light microprojector,” J. Biomed. Opt. 18(9), 096007 (2013).
[Crossref] [PubMed]

Cuplov, V.

M. Mesradi, A. Genoux, V. Cuplov, D. Abi Haidar, S. Jan, I. Buvat, and F. Pain, “Experimental and analytical comparative study of optical coefficient of fresh and frozen rat tissues,” J. Biomed. Opt. 18(11), 117010 (2013).
[Crossref] [PubMed]

Dehghani, H.

D. S. Kepshire, S. L. Gibbs-Strauss, J. A. O’Hara, M. Hutchins, N. Mincu, F. Leblond, M. Khayat, H. Dehghani, S. Srinivasan, and B. W. Pogue, “Imaging of glioma tumor with endogenous fluorescence tomography,” J. Biomed. Opt. 14(3), 030501 (2009).
[Crossref] [PubMed]

Di Ninni, P.

Durduran, T.

Durkin, A. J.

A. J. Lin, A. Ponticorvo, S. D. Konecky, H. Cui, T. B. Rice, B. Choi, A. J. Durkin, and B. J. Tromberg, “Visible spatial frequency domain imaging with a digital light microprojector,” J. Biomed. Opt. 18(9), 096007 (2013).
[Crossref] [PubMed]

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Eliott, J. T.

M. Sibai, I. Veilleux, J. T. Eliott, F. Leblond, D. W. Roberts, and B. C. Wilson, “Quantitative fluorescence imaging enabled by spatial frequency domain optical-property mapping in the sub-diffusive regime for surgical guidance,” Proc. SPIE 93110, 93110C (2015).

Elster, C.

Erickson, T. A.

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

Erkmen, K.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Fan, X.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Farina, A.

Foschum, F.

Gallant, P.

Genoux, A.

M. Mesradi, A. Genoux, V. Cuplov, D. Abi Haidar, S. Jan, I. Buvat, and F. Pain, “Experimental and analytical comparative study of optical coefficient of fresh and frozen rat tissues,” J. Biomed. Opt. 18(11), 117010 (2013).
[Crossref] [PubMed]

Gibbs-Strauss, S. L.

D. S. Kepshire, S. L. Gibbs-Strauss, J. A. O’Hara, M. Hutchins, N. Mincu, F. Leblond, M. Khayat, H. Dehghani, S. Srinivasan, and B. W. Pogue, “Imaging of glioma tumor with endogenous fluorescence tomography,” J. Biomed. Opt. 14(3), 030501 (2009).
[Crossref] [PubMed]

Gosselin, Y.

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

Harris, B. T.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

P. A. Valdés, A. Kim, F. Leblond, O. M. Conde, B. T. Harris, K. D. Paulsen, B. C. Wilson, and D. W. Roberts, “Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery,” J. Biomed. Opt. 16(11), 116007 (2011).
[Crossref] [PubMed]

Hartov, A.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Ho, H. C.

Hutchins, M.

D. S. Kepshire, S. L. Gibbs-Strauss, J. A. O’Hara, M. Hutchins, N. Mincu, F. Leblond, M. Khayat, H. Dehghani, S. Srinivasan, and B. W. Pogue, “Imaging of glioma tumor with endogenous fluorescence tomography,” J. Biomed. Opt. 14(3), 030501 (2009).
[Crossref] [PubMed]

Jacobs, V. L.

Jan, S.

M. Mesradi, A. Genoux, V. Cuplov, D. Abi Haidar, S. Jan, I. Buvat, and F. Pain, “Experimental and analytical comparative study of optical coefficient of fresh and frozen rat tissues,” J. Biomed. Opt. 18(11), 117010 (2013).
[Crossref] [PubMed]

Jeffree, R. L.

M. J. Colditz and R. L. Jeffree, “Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies,” J. Clin. Neurosci. 19(11), 1471–1474 (2012).
[Crossref] [PubMed]

M. J. Colditz, K. Leyen, and R. L. Jeffree, “Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: Theoretical, biochemical and practical aspects,” J. Clin. Neurosci. 19(12), 1611–1616 (2012).
[Crossref] [PubMed]

Jermyn, M.

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

Ji, S.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Jo, J. A.

L. Marcu, J. A. Jo, P. V. Butte, W. H. Yong, B. K. Pikul, K. L. Black, and R. C. Thompson, “Fluorescence lifetime spectroscopy of glioblastoma multiforme,” Photochem. Photobiol. 80(1), 98–103 (2004).
[Crossref] [PubMed]

Kacprzak, M.

Kelly, K. M.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

Kepshire, D. S.

D. S. Kepshire, S. L. Gibbs-Strauss, J. A. O’Hara, M. Hutchins, N. Mincu, F. Leblond, M. Khayat, H. Dehghani, S. Srinivasan, and B. W. Pogue, “Imaging of glioma tumor with endogenous fluorescence tomography,” J. Biomed. Opt. 14(3), 030501 (2009).
[Crossref] [PubMed]

Khayat, M.

D. S. Kepshire, S. L. Gibbs-Strauss, J. A. O’Hara, M. Hutchins, N. Mincu, F. Leblond, M. Khayat, H. Dehghani, S. Srinivasan, and B. W. Pogue, “Imaging of glioma tumor with endogenous fluorescence tomography,” J. Biomed. Opt. 14(3), 030501 (2009).
[Crossref] [PubMed]

Khoptyar, D.

Khurana, M.

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

Kienle, A.

Kim, A.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

P. A. Valdés, A. Kim, F. Leblond, O. M. Conde, B. T. Harris, K. D. Paulsen, B. C. Wilson, and D. W. Roberts, “Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery,” J. Biomed. Opt. 16(11), 116007 (2011).
[Crossref] [PubMed]

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

Klauenberg, K.

Kolste, K. K.

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

Konecky, S. D.

A. J. Lin, A. Ponticorvo, S. D. Konecky, H. Cui, T. B. Rice, B. Choi, A. J. Durkin, and B. J. Tromberg, “Visible spatial frequency domain imaging with a digital light microprojector,” J. Biomed. Opt. 18(9), 096007 (2013).
[Crossref] [PubMed]

Krishnaswamy, V.

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

Laughney, A. M.

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

Leblond, F.

M. Sibai, I. Veilleux, J. T. Eliott, F. Leblond, D. W. Roberts, and B. C. Wilson, “Quantitative fluorescence imaging enabled by spatial frequency domain optical-property mapping in the sub-diffusive regime for surgical guidance,” Proc. SPIE 93110, 93110C (2015).

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

P. A. Valdés, V. L. Jacobs, B. C. Wilson, F. Leblond, D. W. Roberts, and K. D. Paulsen, “System and methods for wide-field quantitative fluorescence imaging during neurosurgery,” Opt. Lett. 38(15), 2786–2788 (2013).
[Crossref] [PubMed]

P. A. Valdés, A. Kim, F. Leblond, O. M. Conde, B. T. Harris, K. D. Paulsen, B. C. Wilson, and D. W. Roberts, “Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery,” J. Biomed. Opt. 16(11), 116007 (2011).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

D. S. Kepshire, S. L. Gibbs-Strauss, J. A. O’Hara, M. Hutchins, N. Mincu, F. Leblond, M. Khayat, H. Dehghani, S. Srinivasan, and B. W. Pogue, “Imaging of glioma tumor with endogenous fluorescence tomography,” J. Biomed. Opt. 14(3), 030501 (2009).
[Crossref] [PubMed]

Leclair, S.

Lesage, F.

Leyen, K.

M. J. Colditz, K. Leyen, and R. L. Jeffree, “Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: Theoretical, biochemical and practical aspects,” J. Clin. Neurosci. 19(12), 1611–1616 (2012).
[Crossref] [PubMed]

Liebert, A.

Lin, A. J.

A. J. Lin, A. Ponticorvo, S. D. Konecky, H. Cui, T. B. Rice, B. Choi, A. J. Durkin, and B. J. Tromberg, “Visible spatial frequency domain imaging with a digital light microprojector,” J. Biomed. Opt. 18(9), 096007 (2013).
[Crossref] [PubMed]

Marcu, L.

L. Marcu, J. A. Jo, P. V. Butte, W. H. Yong, B. K. Pikul, K. L. Black, and R. C. Thompson, “Fluorescence lifetime spectroscopy of glioblastoma multiforme,” Photochem. Photobiol. 80(1), 98–103 (2004).
[Crossref] [PubMed]

Martelli, F.

Mazhar, A.

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

Mazurenka, M.

Meinel, T.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Mermut, O.

Mesradi, M.

M. Mesradi, A. Genoux, V. Cuplov, D. Abi Haidar, S. Jan, I. Buvat, and F. Pain, “Experimental and analytical comparative study of optical coefficient of fresh and frozen rat tissues,” J. Biomed. Opt. 18(11), 117010 (2013).
[Crossref] [PubMed]

Michels, R.

Milej, D.

Mincu, N.

D. S. Kepshire, S. L. Gibbs-Strauss, J. A. O’Hara, M. Hutchins, N. Mincu, F. Leblond, M. Khayat, H. Dehghani, S. Srinivasan, and B. W. Pogue, “Imaging of glioma tumor with endogenous fluorescence tomography,” J. Biomed. Opt. 14(3), 030501 (2009).
[Crossref] [PubMed]

Mok, K.

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

Moriyama, Y.

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

Noiseux, I.

O’Hara, J. A.

D. S. Kepshire, S. L. Gibbs-Strauss, J. A. O’Hara, M. Hutchins, N. Mincu, F. Leblond, M. Khayat, H. Dehghani, S. Srinivasan, and B. W. Pogue, “Imaging of glioma tumor with endogenous fluorescence tomography,” J. Biomed. Opt. 14(3), 030501 (2009).
[Crossref] [PubMed]

Pain, F.

M. Mesradi, A. Genoux, V. Cuplov, D. Abi Haidar, S. Jan, I. Buvat, and F. Pain, “Experimental and analytical comparative study of optical coefficient of fresh and frozen rat tissues,” J. Biomed. Opt. 18(11), 117010 (2013).
[Crossref] [PubMed]

Paulsen, K. D.

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

P. A. Valdés, V. L. Jacobs, B. C. Wilson, F. Leblond, D. W. Roberts, and K. D. Paulsen, “System and methods for wide-field quantitative fluorescence imaging during neurosurgery,” Opt. Lett. 38(15), 2786–2788 (2013).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

P. A. Valdés, A. Kim, F. Leblond, O. M. Conde, B. T. Harris, K. D. Paulsen, B. C. Wilson, and D. W. Roberts, “Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery,” J. Biomed. Opt. 16(11), 116007 (2011).
[Crossref] [PubMed]

Petrecca, K.

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

Pichette, J.

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

Pichlmeier, U.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Pifferi, A.

Pikul, B. K.

L. Marcu, J. A. Jo, P. V. Butte, W. H. Yong, B. K. Pikul, K. L. Black, and R. C. Thompson, “Fluorescence lifetime spectroscopy of glioblastoma multiforme,” Photochem. Photobiol. 80(1), 98–103 (2004).
[Crossref] [PubMed]

Pogue, B. W.

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

D. S. Kepshire, S. L. Gibbs-Strauss, J. A. O’Hara, M. Hutchins, N. Mincu, F. Leblond, M. Khayat, H. Dehghani, S. Srinivasan, and B. W. Pogue, “Imaging of glioma tumor with endogenous fluorescence tomography,” J. Biomed. Opt. 14(3), 030501 (2009).
[Crossref] [PubMed]

Ponticorvo, A.

A. J. Lin, A. Ponticorvo, S. D. Konecky, H. Cui, T. B. Rice, B. Choi, A. J. Durkin, and B. J. Tromberg, “Visible spatial frequency domain imaging with a digital light microprojector,” J. Biomed. Opt. 18(9), 096007 (2013).
[Crossref] [PubMed]

Reulen, H. J.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Rice, T. B.

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

A. J. Lin, A. Ponticorvo, S. D. Konecky, H. Cui, T. B. Rice, B. Choi, A. J. Durkin, and B. J. Tromberg, “Visible spatial frequency domain imaging with a digital light microprojector,” J. Biomed. Opt. 18(9), 096007 (2013).
[Crossref] [PubMed]

Roberts, D. W.

M. Sibai, I. Veilleux, J. T. Eliott, F. Leblond, D. W. Roberts, and B. C. Wilson, “Quantitative fluorescence imaging enabled by spatial frequency domain optical-property mapping in the sub-diffusive regime for surgical guidance,” Proc. SPIE 93110, 93110C (2015).

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

P. A. Valdés, V. L. Jacobs, B. C. Wilson, F. Leblond, D. W. Roberts, and K. D. Paulsen, “System and methods for wide-field quantitative fluorescence imaging during neurosurgery,” Opt. Lett. 38(15), 2786–2788 (2013).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

P. A. Valdés, A. Kim, F. Leblond, O. M. Conde, B. T. Harris, K. D. Paulsen, B. C. Wilson, and D. W. Roberts, “Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery,” J. Biomed. Opt. 16(11), 116007 (2011).
[Crossref] [PubMed]

Saager, R. B.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

Saggese, S.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

Sawosz, P.

Sharma, M.

B. Yang, M. Sharma, and J. W. Tunnell, “Attenuation-corrected fluorescence extraction for image-guided surgery in spatial frequency domain,” J. Biomed. Opt. 18(8), 080503 (2013).
[Crossref] [PubMed]

Sibai, M.

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

M. Sibai, I. Veilleux, J. T. Eliott, F. Leblond, D. W. Roberts, and B. C. Wilson, “Quantitative fluorescence imaging enabled by spatial frequency domain optical-property mapping in the sub-diffusive regime for surgical guidance,” Proc. SPIE 93110, 93110C (2015).

Simmons, N. E.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Spinelli, L.

Srinivasan, S.

D. S. Kepshire, S. L. Gibbs-Strauss, J. A. O’Hara, M. Hutchins, N. Mincu, F. Leblond, M. Khayat, H. Dehghani, S. Srinivasan, and B. W. Pogue, “Imaging of glioma tumor with endogenous fluorescence tomography,” J. Biomed. Opt. 14(3), 030501 (2009).
[Crossref] [PubMed]

Stummer, W.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Subash, A. A.

Thompson, R. C.

L. Marcu, J. A. Jo, P. V. Butte, W. H. Yong, B. K. Pikul, K. L. Black, and R. C. Thompson, “Fluorescence lifetime spectroscopy of glioblastoma multiforme,” Photochem. Photobiol. 80(1), 98–103 (2004).
[Crossref] [PubMed]

Torricelli, A.

Tosteson, T. D.

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Tromberg, B. J.

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

A. J. Lin, A. Ponticorvo, S. D. Konecky, H. Cui, T. B. Rice, B. Choi, A. J. Durkin, and B. J. Tromberg, “Visible spatial frequency domain imaging with a digital light microprojector,” J. Biomed. Opt. 18(9), 096007 (2013).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Tunnell, J. W.

B. Yang, M. Sharma, and J. W. Tunnell, “Attenuation-corrected fluorescence extraction for image-guided surgery in spatial frequency domain,” J. Biomed. Opt. 18(8), 080503 (2013).
[Crossref] [PubMed]

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

Valdes, P. A.

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

Valdés, P. A.

P. A. Valdés, V. L. Jacobs, B. C. Wilson, F. Leblond, D. W. Roberts, and K. D. Paulsen, “System and methods for wide-field quantitative fluorescence imaging during neurosurgery,” Opt. Lett. 38(15), 2786–2788 (2013).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

P. A. Valdés, A. Kim, F. Leblond, O. M. Conde, B. T. Harris, K. D. Paulsen, B. C. Wilson, and D. W. Roberts, “Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery,” J. Biomed. Opt. 16(11), 116007 (2011).
[Crossref] [PubMed]

Veilleux, I.

M. Sibai, I. Veilleux, J. T. Eliott, F. Leblond, D. W. Roberts, and B. C. Wilson, “Quantitative fluorescence imaging enabled by spatial frequency domain optical-property mapping in the sub-diffusive regime for surgical guidance,” Proc. SPIE 93110, 93110C (2015).

Wabnitz, H.

Weigel, U.

Wells, W. A.

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

Wiestler, O. D.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Wilson, B. C.

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

M. Sibai, I. Veilleux, J. T. Eliott, F. Leblond, D. W. Roberts, and B. C. Wilson, “Quantitative fluorescence imaging enabled by spatial frequency domain optical-property mapping in the sub-diffusive regime for surgical guidance,” Proc. SPIE 93110, 93110C (2015).

P. A. Valdés, V. L. Jacobs, B. C. Wilson, F. Leblond, D. W. Roberts, and K. D. Paulsen, “System and methods for wide-field quantitative fluorescence imaging during neurosurgery,” Opt. Lett. 38(15), 2786–2788 (2013).
[Crossref] [PubMed]

P. A. Valdés, A. Kim, F. Leblond, O. M. Conde, B. T. Harris, K. D. Paulsen, B. C. Wilson, and D. W. Roberts, “Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery,” J. Biomed. Opt. 16(11), 116007 (2011).
[Crossref] [PubMed]

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

Yang, B.

B. Yang, M. Sharma, and J. W. Tunnell, “Attenuation-corrected fluorescence extraction for image-guided surgery in spatial frequency domain,” J. Biomed. Opt. 18(8), 080503 (2013).
[Crossref] [PubMed]

Yong, W. H.

L. Marcu, J. A. Jo, P. V. Butte, W. H. Yong, B. K. Pikul, K. L. Black, and R. C. Thompson, “Fluorescence lifetime spectroscopy of glioblastoma multiforme,” Photochem. Photobiol. 80(1), 98–103 (2004).
[Crossref] [PubMed]

Zaccanti, G.

Zanella, F.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Zolek, N.

Biomed. Opt. Express (1)

J. Biomed. Opt. (10)

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

D. S. Kepshire, S. L. Gibbs-Strauss, J. A. O’Hara, M. Hutchins, N. Mincu, F. Leblond, M. Khayat, H. Dehghani, S. Srinivasan, and B. W. Pogue, “Imaging of glioma tumor with endogenous fluorescence tomography,” J. Biomed. Opt. 14(3), 030501 (2009).
[Crossref] [PubMed]

M. Mesradi, A. Genoux, V. Cuplov, D. Abi Haidar, S. Jan, I. Buvat, and F. Pain, “Experimental and analytical comparative study of optical coefficient of fresh and frozen rat tissues,” J. Biomed. Opt. 18(11), 117010 (2013).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

B. Yang, M. Sharma, and J. W. Tunnell, “Attenuation-corrected fluorescence extraction for image-guided surgery in spatial frequency domain,” J. Biomed. Opt. 18(8), 080503 (2013).
[Crossref] [PubMed]

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

A. J. Lin, A. Ponticorvo, S. D. Konecky, H. Cui, T. B. Rice, B. Choi, A. J. Durkin, and B. J. Tromberg, “Visible spatial frequency domain imaging with a digital light microprojector,” J. Biomed. Opt. 18(9), 096007 (2013).
[Crossref] [PubMed]

P. A. Valdés, A. Kim, F. Leblond, O. M. Conde, B. T. Harris, K. D. Paulsen, B. C. Wilson, and D. W. Roberts, “Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery,” J. Biomed. Opt. 16(11), 116007 (2011).
[Crossref] [PubMed]

J. Clin. Neurosci. (2)

M. J. Colditz and R. L. Jeffree, “Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies,” J. Clin. Neurosci. 19(11), 1471–1474 (2012).
[Crossref] [PubMed]

M. J. Colditz, K. Leyen, and R. L. Jeffree, “Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: Theoretical, biochemical and practical aspects,” J. Clin. Neurosci. 19(12), 1611–1616 (2012).
[Crossref] [PubMed]

J. Neurosurg. (1)

P. A. Valdés, F. Leblond, A. Kim, B. T. Harris, B. C. Wilson, X. Fan, T. D. Tosteson, A. Hartov, S. Ji, K. Erkmen, N. E. Simmons, K. D. Paulsen, and D. W. Roberts, “Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker,” J. Neurosurg. 115(1), 11–17 (2011).
[Crossref] [PubMed]

Lancet Oncol. (1)

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Opt. Express (1)

Opt. Lett. (1)

Photochem. Photobiol. (1)

L. Marcu, J. A. Jo, P. V. Butte, W. H. Yong, B. K. Pikul, K. L. Black, and R. C. Thompson, “Fluorescence lifetime spectroscopy of glioblastoma multiforme,” Photochem. Photobiol. 80(1), 98–103 (2004).
[Crossref] [PubMed]

Proc. SPIE (2)

M. Sibai, I. Veilleux, J. T. Eliott, F. Leblond, D. W. Roberts, and B. C. Wilson, “Quantitative fluorescence imaging enabled by spatial frequency domain optical-property mapping in the sub-diffusive regime for surgical guidance,” Proc. SPIE 93110, 93110C (2015).

L. M. Angulo-Rodrigues, M. Jermyn, K. K. Kolste, P. A. Valdes, J. Pichette, Y. Gosselin, M. Sibai, K. Mok, K. Petrecca, D. W. Roberts, K. D. Paulsen, B. C. Wilson, and F. Leblond, “A surgical microscope combining real-time surface reconstruction and spectroscopic fluorescence imaging with a light transport model to quantify visible and near-infrared fluorescent molecular markers,” Proc. SPIE 9313, 9313C (2015).

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Figures (3)

Fig. 1
Fig. 1 (a) Photograph of the SFDI qFI system; (b) corresponding schematic with the liquid light guide (LGG), digital micromirror device (DMD), lenses (L1, L2), mirror (M1), liquid crystal tunable filter (LCTF), charge-coupled device (CCD) and the sample stage.
Fig. 2
Fig. 2 (a) Raw fluorescence images for tissue phantoms with [PpIX] = 5µg/ml; (b) Derived fluorescence images after applying the qFI model. The phantom optical properties are shown in Table 1 and the images are displayed in order of increasing transport coefficient, µTR, (c) Corresponding plot of the mean quantitative fluorescent intensity of each image normalized to the mean fluorescent intensity. The error bars denote the standard deviation across each image relative to its mean intensity.
Fig. 3
Fig. 3 (a) Raw fluorescence image at 640 nm for the chicken sample with [PpIX] = 1µg/ml; (b) Derived fluorescence images after applying the qFI model.

Tables (5)

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Table 1 Summary of phantom optical properties used to test the qFI model in order of increasing transport albedo, each used with 5 µg/ml PpIX concentration

Tables Icon

Table 2 Accuracy in recovering phantom optical properties in the diffusive regime at 635 nm

Tables Icon

Table 3 Accuracy in recovering phantom optical properties in the sub-diffusive regime

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Table 4 Comparison of the relative and maximum standard deviation values for the PpIX phantoms, normalized to the mean in each case, using 3 different algorithms

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Table 5 Comparison of SFD-qFI derived optical properties (mm−1) and [PpIX] (µg/ml) with those derived by qFS. The known [PpIX] added to chicken and beef were 1.0 µg/l and 3.0 µg/l

Equations (9)

Equations on this page are rendered with MathJax. Learn more.

S= S 0 + A 0 .cos(2π f x x+φ)
I AC (x, f x )= M AC (x, f x ).cos(2π f x x+ φ i )
M AC ( x i , f x )= 2×{ [ I 1 (x) I 2 (x)] 2 + [ I 1 (x) I 3 (x)] 2 + [ I 2 (x) I 3 (x)] 2 } 3
M DC ( x i )= I 1 ( x i )+ I 2 ( x i )+ I 3 ( x i ) 3
R d ( x i , f x )= M AC sample ( x i , f x ) M AC ref ( x i , f x ) . R d ref ( x i , f x )
q f x,m = Q x,m . μ af,x = Q x,m . ε x,m .[PpIX],
F m (λ)= q f x,m .(1 R tx ). R m (λ) μ a,x
q f x,m = Q x,m . μ af,x = μ a,x . F m (λ) (1 R tx ). R m (λ) ,
q f x,m (x,y,λ)= μ a,x (x,y). F m (x,y.λ) (1 R x (x,y)). R m (x,y,λ)

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