Abstract

We present the first endoscopic Doppler optical coherence tomography and co-registered autofluorescence imaging (DOCT-AFI) of peripheral pulmonary nodules and vascular networks in vivo using a small 0.9 mm diameter catheter. Using exemplary images from volumetric data sets collected from 31 patients during flexible bronchoscopy, we demonstrate how DOCT and AFI offer complementary information that may increase the ability to locate and characterize pulmonary nodules. AFI offers a sensitive visual presentation for the rapid identification of suspicious airway sites, while co-registered OCT provides detailed structural information to assess the airway morphology. We demonstrate the ability of AFI to visualize vascular networks in vivo and validate this finding using Doppler and structural OCT. Given the advantages of higher resolution, smaller probe size, and ability to visualize vasculature, DOCT-AFI has the potential to increase diagnostic accuracy and minimize bleeding to guide biopsy of pulmonary nodules compared to radial endobronchial ultrasound, the current standard of care.

© 2015 Optical Society of America

Full Article  |  PDF Article
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References

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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  22. L. P. Hariri, M. Mino-Kenudson, M. B. Applegate, E. J. Mark, G. J. Tearney, M. Lanuti, C. L. Channick, A. Chee, and M. J. Suter, “Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography,” Chest 144(4), 1261–1268 (2013).
    [Crossref] [PubMed]
  23. L. P. Hariri, M. Villiger, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. E. Bouma, and M. J. Suter, “Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy,” Am. J. Respir. Crit. Care Med. 187(2), 125–129 (2013).
    [Crossref] [PubMed]
  24. L. P. Hariri, M. Mino-Kenudson, M. Lanuti, A. J. Miller, E. J. Mark, and M. J. Suter, “Diagnosing lung carcinomas with optical coherence tomography,” Ann. Am. Thorac. Soc. 12(2), 193–201 (2015).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  26. S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
    [Crossref] [PubMed]
  27. P. Carmeliet and R. K. Jain, “Angiogenesis in cancer and other diseases,” Nature 407(6801), 249–257 (2000).
    [Crossref] [PubMed]
  28. S. K. Carter, “Clinical strategy for the development of angiogenesis inhibitors,” Oncologist 5(90001Suppl 1), 51–54 (2000).
    [Crossref] [PubMed]

2015 (2)

2014 (2)

H. Pahlevaninezhad, A. M. D. Lee, T. Shaipanich, R. Raizada, L. Cahill, G. Hohert, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography,” Biomed. Opt. Express 5(9), 2978–2987 (2014).
[Crossref] [PubMed]

A. Chen, P. Chenna, A. Loiselle, J. Massoni, M. Mayse, and D. Misselhorn, “Radial probe endobronchial ultrasound for peripheral pulmonary lesions. A 5-year institutional experience,” Ann. Am. Thorac. Soc. 11(4), 578–582 (2014).
[Crossref] [PubMed]

2013 (7)

J. H. Tay, L. Irving, P. Antippa, and D. P. Steinfort, “Radial probe endobronchial ultrasound: factors influencing visualization yield of peripheral pulmonary lesions,” Respirology 18(1), 185–190 (2013).
[Crossref] [PubMed]

A. McWilliams, T. Shaipanich, and S. Lam, “Fluorescence and navigational bronchoscopy,” Thorac. Surg. Clin. 23(2), 153–161 (2013).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. B. Applegate, M. M. Kenudson, E. J. Mark, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation,” J. Vis. Exp. 71, 3855 (2013).

L. P. Hariri, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. D. Medoff, A. D. Luster, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology,” Chest 143(1), 64–74 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. Mino-Kenudson, M. B. Applegate, E. J. Mark, G. J. Tearney, M. Lanuti, C. L. Channick, A. Chee, and M. J. Suter, “Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography,” Chest 144(4), 1261–1268 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. Villiger, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. E. Bouma, and M. J. Suter, “Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy,” Am. J. Respir. Crit. Care Med. 187(2), 125–129 (2013).
[Crossref] [PubMed]

2012 (3)

J. S. Wang Memoli, P. J. Nietert, and G. A. Silvestri, “Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule,” Chest 142(2), 385–393 (2012).
[Crossref] [PubMed]

W. J. Lee, S. Chong, J. S. Seo, and H. J. Shim, “Transthoracic fine-needle aspiration biopsy of the lungs using a C-arm cone-beam CT system: diagnostic accuracy and post-procedural complications,” Br. J. Radiol. 85(1014), e217–e222 (2012).
[Crossref] [PubMed]

K. M. Tan, M. Shishkov, A. Chee, M. B. Applegate, B. E. Bouma, and M. J. Suter, “Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance,” Biomed. Opt. Express 3(8), 1947–1954 (2012).
[Crossref] [PubMed]

2011 (3)

B. C. Quirk, R. A. McLaughlin, A. Curatolo, R. W. Kirk, P. B. Noble, and D. D. Sampson, “In situ imaging of lung alveoli with an optical coherence tomography needle probe,” J. Biomed. Opt. 16(3), 036009 (2011).
[Crossref] [PubMed]

D. Lorenser, X. Yang, R. W. Kirk, B. C. Quirk, R. A. McLaughlin, and D. D. Sampson, “Ultrathin side-viewing needle probe for optical coherence tomography,” Opt. Lett. 36(19), 3894–3896 (2011).
[Crossref] [PubMed]

R. S. Wiener, L. M. Schwartz, S. Woloshin, and H. G. Welch, “Population-based risk for complications after transthoracic needle lung biopsy of a pulmonary nodule: an analysis of discharge records,” Ann. Intern. Med. 155(3), 137–144 (2011).
[Crossref] [PubMed]

2008 (1)

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

2004 (1)

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

2001 (1)

T. C. Kennedy, S. Lam, and F. R. Hirsch, “Review of recent advances in fluorescence bronchoscopy in early localization of central airway lung cancer,” Oncologist 6(3), 257–262 (2001).
[Crossref] [PubMed]

2000 (2)

P. Carmeliet and R. K. Jain, “Angiogenesis in cancer and other diseases,” Nature 407(6801), 249–257 (2000).
[Crossref] [PubMed]

S. K. Carter, “Clinical strategy for the development of angiogenesis inhibitors,” Oncologist 5(90001Suppl 1), 51–54 (2000).
[Crossref] [PubMed]

1998 (1)

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

1997 (1)

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[Crossref] [PubMed]

1995 (1)

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical Biopsy and Imaging Using Optical Coherence Tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref] [PubMed]

1991 (2)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

J. Hung, S. Lam, J. C. LeRiche, and B. Palcic, “Autofluorescence of normal and malignant bronchial tissue,” Lasers Surg. Med. 11(2), 99–105 (1991).
[Crossref] [PubMed]

Antippa, P.

J. H. Tay, L. Irving, P. Antippa, and D. P. Steinfort, “Radial probe endobronchial ultrasound: factors influencing visualization yield of peripheral pulmonary lesions,” Respirology 18(1), 185–190 (2013).
[Crossref] [PubMed]

Applegate, M. B.

L. P. Hariri, M. B. Applegate, M. M. Kenudson, E. J. Mark, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation,” J. Vis. Exp. 71, 3855 (2013).

L. P. Hariri, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. D. Medoff, A. D. Luster, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology,” Chest 143(1), 64–74 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. Mino-Kenudson, M. B. Applegate, E. J. Mark, G. J. Tearney, M. Lanuti, C. L. Channick, A. Chee, and M. J. Suter, “Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography,” Chest 144(4), 1261–1268 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. Villiger, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. E. Bouma, and M. J. Suter, “Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy,” Am. J. Respir. Crit. Care Med. 187(2), 125–129 (2013).
[Crossref] [PubMed]

K. M. Tan, M. Shishkov, A. Chee, M. B. Applegate, B. E. Bouma, and M. J. Suter, “Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance,” Biomed. Opt. Express 3(8), 1947–1954 (2012).
[Crossref] [PubMed]

Baldwin, C.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Boppart, S. A.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[Crossref] [PubMed]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical Biopsy and Imaging Using Optical Coherence Tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref] [PubMed]

Boudoux, C.

Bouma, B.

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical Biopsy and Imaging Using Optical Coherence Tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref] [PubMed]

Bouma, B. E.

L. P. Hariri, M. Villiger, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. E. Bouma, and M. J. Suter, “Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy,” Am. J. Respir. Crit. Care Med. 187(2), 125–129 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. D. Medoff, A. D. Luster, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology,” Chest 143(1), 64–74 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. B. Applegate, M. M. Kenudson, E. J. Mark, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation,” J. Vis. Exp. 71, 3855 (2013).

K. M. Tan, M. Shishkov, A. Chee, M. B. Applegate, B. E. Bouma, and M. J. Suter, “Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance,” Biomed. Opt. Express 3(8), 1947–1954 (2012).
[Crossref] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[Crossref] [PubMed]

Brezinski, M. E.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[Crossref] [PubMed]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical Biopsy and Imaging Using Optical Coherence Tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref] [PubMed]

Cahill, L.

Carmeliet, P.

P. Carmeliet and R. K. Jain, “Angiogenesis in cancer and other diseases,” Nature 407(6801), 249–257 (2000).
[Crossref] [PubMed]

Carter, S. K.

S. K. Carter, “Clinical strategy for the development of angiogenesis inhibitors,” Oncologist 5(90001Suppl 1), 51–54 (2000).
[Crossref] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Channick, C. L.

L. P. Hariri, M. Mino-Kenudson, M. B. Applegate, E. J. Mark, G. J. Tearney, M. Lanuti, C. L. Channick, A. Chee, and M. J. Suter, “Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography,” Chest 144(4), 1261–1268 (2013).
[Crossref] [PubMed]

Chee, A.

L. P. Hariri, M. Mino-Kenudson, M. B. Applegate, E. J. Mark, G. J. Tearney, M. Lanuti, C. L. Channick, A. Chee, and M. J. Suter, “Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography,” Chest 144(4), 1261–1268 (2013).
[Crossref] [PubMed]

K. M. Tan, M. Shishkov, A. Chee, M. B. Applegate, B. E. Bouma, and M. J. Suter, “Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance,” Biomed. Opt. Express 3(8), 1947–1954 (2012).
[Crossref] [PubMed]

Chen, A.

A. Chen, P. Chenna, A. Loiselle, J. Massoni, M. Mayse, and D. Misselhorn, “Radial probe endobronchial ultrasound for peripheral pulmonary lesions. A 5-year institutional experience,” Ann. Am. Thorac. Soc. 11(4), 578–582 (2014).
[Crossref] [PubMed]

Chenna, P.

A. Chen, P. Chenna, A. Loiselle, J. Massoni, M. Mayse, and D. Misselhorn, “Radial probe endobronchial ultrasound for peripheral pulmonary lesions. A 5-year institutional experience,” Ann. Am. Thorac. Soc. 11(4), 578–582 (2014).
[Crossref] [PubMed]

Chong, S.

W. J. Lee, S. Chong, J. S. Seo, and H. J. Shim, “Transthoracic fine-needle aspiration biopsy of the lungs using a C-arm cone-beam CT system: diagnostic accuracy and post-procedural complications,” Br. J. Radiol. 85(1014), e217–e222 (2012).
[Crossref] [PubMed]

Coldman, A.

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

Curatolo, A.

B. C. Quirk, R. A. McLaughlin, A. Curatolo, R. W. Kirk, P. B. Noble, and D. D. Sampson, “In situ imaging of lung alveoli with an optical coherence tomography needle probe,” J. Biomed. Opt. 16(3), 036009 (2011).
[Crossref] [PubMed]

Dyachkova, Y.

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Fujimoto, J. G.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[Crossref] [PubMed]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical Biopsy and Imaging Using Optical Coherence Tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Gazdar, A.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

Gazdar, A. F.

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

Gelmont, D.

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

Gipe, B.

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

Godbout, N.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Hariri, L. P.

L. P. Hariri, M. Mino-Kenudson, M. Lanuti, A. J. Miller, E. J. Mark, and M. J. Suter, “Diagnosing lung carcinomas with optical coherence tomography,” Ann. Am. Thorac. Soc. 12(2), 193–201 (2015).
[Crossref] [PubMed]

L. P. Hariri, M. Villiger, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. E. Bouma, and M. J. Suter, “Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy,” Am. J. Respir. Crit. Care Med. 187(2), 125–129 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. Mino-Kenudson, M. B. Applegate, E. J. Mark, G. J. Tearney, M. Lanuti, C. L. Channick, A. Chee, and M. J. Suter, “Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography,” Chest 144(4), 1261–1268 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. B. Applegate, M. M. Kenudson, E. J. Mark, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation,” J. Vis. Exp. 71, 3855 (2013).

L. P. Hariri, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. D. Medoff, A. D. Luster, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology,” Chest 143(1), 64–74 (2013).
[Crossref] [PubMed]

Hawk, E.

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

Hee, M. R.

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical Biopsy and Imaging Using Optical Coherence Tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Hirsch, F. R.

T. C. Kennedy, S. Lam, and F. R. Hirsch, “Review of recent advances in fluorescence bronchoscopy in early localization of central airway lung cancer,” Oncologist 6(3), 257–262 (2001).
[Crossref] [PubMed]

Hohert, G.

Howard, D.

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Hung, J.

J. Hung, S. Lam, J. C. LeRiche, and B. Palcic, “Autofluorescence of normal and malignant bronchial tissue,” Lasers Surg. Med. 11(2), 99–105 (1991).
[Crossref] [PubMed]

Ikeda, N.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Irving, L.

J. H. Tay, L. Irving, P. Antippa, and D. P. Steinfort, “Radial probe endobronchial ultrasound: factors influencing visualization yield of peripheral pulmonary lesions,” Respirology 18(1), 185–190 (2013).
[Crossref] [PubMed]

Jain, R. K.

P. Carmeliet and R. K. Jain, “Angiogenesis in cancer and other diseases,” Nature 407(6801), 249–257 (2000).
[Crossref] [PubMed]

Kennedy, T.

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

Kennedy, T. C.

T. C. Kennedy, S. Lam, and F. R. Hirsch, “Review of recent advances in fluorescence bronchoscopy in early localization of central airway lung cancer,” Oncologist 6(3), 257–262 (2001).
[Crossref] [PubMed]

Kenudson, M. M.

L. P. Hariri, M. B. Applegate, M. M. Kenudson, E. J. Mark, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation,” J. Vis. Exp. 71, 3855 (2013).

Kirk, R. W.

Kramer, A. S.

Lam, S.

H. Pahlevaninezhad, A. M. D. Lee, T. Shaipanich, R. Raizada, L. Cahill, G. Hohert, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography,” Biomed. Opt. Express 5(9), 2978–2987 (2014).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

A. McWilliams, T. Shaipanich, and S. Lam, “Fluorescence and navigational bronchoscopy,” Thorac. Surg. Clin. 23(2), 153–161 (2013).
[Crossref] [PubMed]

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

T. C. Kennedy, S. Lam, and F. R. Hirsch, “Review of recent advances in fluorescence bronchoscopy in early localization of central airway lung cancer,” Oncologist 6(3), 257–262 (2001).
[Crossref] [PubMed]

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

J. Hung, S. Lam, J. C. LeRiche, and B. Palcic, “Autofluorescence of normal and malignant bronchial tissue,” Lasers Surg. Med. 11(2), 99–105 (1991).
[Crossref] [PubMed]

Lane, P.

H. Pahlevaninezhad, A. M. D. Lee, T. Shaipanich, R. Raizada, L. Cahill, G. Hohert, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography,” Biomed. Opt. Express 5(9), 2978–2987 (2014).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Lanuti, M.

L. P. Hariri, M. Mino-Kenudson, M. Lanuti, A. J. Miller, E. J. Mark, and M. J. Suter, “Diagnosing lung carcinomas with optical coherence tomography,” Ann. Am. Thorac. Soc. 12(2), 193–201 (2015).
[Crossref] [PubMed]

L. P. Hariri, M. Mino-Kenudson, M. B. Applegate, E. J. Mark, G. J. Tearney, M. Lanuti, C. L. Channick, A. Chee, and M. J. Suter, “Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography,” Chest 144(4), 1261–1268 (2013).
[Crossref] [PubMed]

Lee, A. M. D.

H. Pahlevaninezhad, A. M. D. Lee, T. Shaipanich, R. Raizada, L. Cahill, G. Hohert, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography,” Biomed. Opt. Express 5(9), 2978–2987 (2014).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Lee, W. J.

W. J. Lee, S. Chong, J. S. Seo, and H. J. Shim, “Transthoracic fine-needle aspiration biopsy of the lungs using a C-arm cone-beam CT system: diagnostic accuracy and post-procedural complications,” Br. J. Radiol. 85(1014), e217–e222 (2012).
[Crossref] [PubMed]

leRiche, J.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

leRiche, J. C.

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

J. Hung, S. Lam, J. C. LeRiche, and B. Palcic, “Autofluorescence of normal and malignant bronchial tissue,” Lasers Surg. Med. 11(2), 99–105 (1991).
[Crossref] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Loiselle, A.

A. Chen, P. Chenna, A. Loiselle, J. Massoni, M. Mayse, and D. Misselhorn, “Radial probe endobronchial ultrasound for peripheral pulmonary lesions. A 5-year institutional experience,” Ann. Am. Thorac. Soc. 11(4), 578–582 (2014).
[Crossref] [PubMed]

Lorenser, D.

Luster, A. D.

L. P. Hariri, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. D. Medoff, A. D. Luster, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology,” Chest 143(1), 64–74 (2013).
[Crossref] [PubMed]

MacAulay, C.

H. Pahlevaninezhad, A. M. D. Lee, T. Shaipanich, R. Raizada, L. Cahill, G. Hohert, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography,” Biomed. Opt. Express 5(9), 2978–2987 (2014).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

Madore, W. J.

Mark, E. J.

L. P. Hariri, M. Mino-Kenudson, M. Lanuti, A. J. Miller, E. J. Mark, and M. J. Suter, “Diagnosing lung carcinomas with optical coherence tomography,” Ann. Am. Thorac. Soc. 12(2), 193–201 (2015).
[Crossref] [PubMed]

L. P. Hariri, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. D. Medoff, A. D. Luster, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology,” Chest 143(1), 64–74 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. B. Applegate, M. M. Kenudson, E. J. Mark, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation,” J. Vis. Exp. 71, 3855 (2013).

L. P. Hariri, M. Villiger, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. E. Bouma, and M. J. Suter, “Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy,” Am. J. Respir. Crit. Care Med. 187(2), 125–129 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. Mino-Kenudson, M. B. Applegate, E. J. Mark, G. J. Tearney, M. Lanuti, C. L. Channick, A. Chee, and M. J. Suter, “Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography,” Chest 144(4), 1261–1268 (2013).
[Crossref] [PubMed]

Massoni, J.

A. Chen, P. Chenna, A. Loiselle, J. Massoni, M. Mayse, and D. Misselhorn, “Radial probe endobronchial ultrasound for peripheral pulmonary lesions. A 5-year institutional experience,” Ann. Am. Thorac. Soc. 11(4), 578–582 (2014).
[Crossref] [PubMed]

Mayo, J.

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

Mayse, M.

A. Chen, P. Chenna, A. Loiselle, J. Massoni, M. Mayse, and D. Misselhorn, “Radial probe endobronchial ultrasound for peripheral pulmonary lesions. A 5-year institutional experience,” Ann. Am. Thorac. Soc. 11(4), 578–582 (2014).
[Crossref] [PubMed]

McLaughlin, R. A.

McWilliams, A.

A. McWilliams, T. Shaipanich, and S. Lam, “Fluorescence and navigational bronchoscopy,” Thorac. Surg. Clin. 23(2), 153–161 (2013).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

Medoff, B. D.

L. P. Hariri, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. D. Medoff, A. D. Luster, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology,” Chest 143(1), 64–74 (2013).
[Crossref] [PubMed]

Miller, A. J.

L. P. Hariri, M. Mino-Kenudson, M. Lanuti, A. J. Miller, E. J. Mark, and M. J. Suter, “Diagnosing lung carcinomas with optical coherence tomography,” Ann. Am. Thorac. Soc. 12(2), 193–201 (2015).
[Crossref] [PubMed]

Miller, Y. E.

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

Mino-Kenudson, M.

L. P. Hariri, M. Mino-Kenudson, M. Lanuti, A. J. Miller, E. J. Mark, and M. J. Suter, “Diagnosing lung carcinomas with optical coherence tomography,” Ann. Am. Thorac. Soc. 12(2), 193–201 (2015).
[Crossref] [PubMed]

L. P. Hariri, M. Villiger, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. E. Bouma, and M. J. Suter, “Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy,” Am. J. Respir. Crit. Care Med. 187(2), 125–129 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. Mino-Kenudson, M. B. Applegate, E. J. Mark, G. J. Tearney, M. Lanuti, C. L. Channick, A. Chee, and M. J. Suter, “Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography,” Chest 144(4), 1261–1268 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. D. Medoff, A. D. Luster, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology,” Chest 143(1), 64–74 (2013).
[Crossref] [PubMed]

Misselhorn, D.

A. Chen, P. Chenna, A. Loiselle, J. Massoni, M. Mayse, and D. Misselhorn, “Radial probe endobronchial ultrasound for peripheral pulmonary lesions. A 5-year institutional experience,” Ann. Am. Thorac. Soc. 11(4), 578–582 (2014).
[Crossref] [PubMed]

Nietert, P. J.

J. S. Wang Memoli, P. J. Nietert, and G. A. Silvestri, “Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule,” Chest 142(2), 385–393 (2012).
[Crossref] [PubMed]

Noble, P. B.

B. C. Quirk, R. A. McLaughlin, A. Curatolo, R. W. Kirk, P. B. Noble, and D. D. Sampson, “In situ imaging of lung alveoli with an optical coherence tomography needle probe,” J. Biomed. Opt. 16(3), 036009 (2011).
[Crossref] [PubMed]

Ohtani, K.

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Pahlevaninezhad, H.

Palcic, B.

J. Hung, S. Lam, J. C. LeRiche, and B. Palcic, “Autofluorescence of normal and malignant bronchial tissue,” Lasers Surg. Med. 11(2), 99–105 (1991).
[Crossref] [PubMed]

Pitris, C.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[Crossref] [PubMed]

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Quirk, B. C.

B. C. Quirk, R. A. McLaughlin, A. Curatolo, R. W. Kirk, P. B. Noble, and D. D. Sampson, “In situ imaging of lung alveoli with an optical coherence tomography needle probe,” J. Biomed. Opt. 16(3), 036009 (2011).
[Crossref] [PubMed]

D. Lorenser, X. Yang, R. W. Kirk, B. C. Quirk, R. A. McLaughlin, and D. D. Sampson, “Ultrathin side-viewing needle probe for optical coherence tomography,” Opt. Lett. 36(19), 3894–3896 (2011).
[Crossref] [PubMed]

Raizada, R.

Rusch, V.

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

Sampson, D. D.

Schellenberg, R.

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Schwartz, L. M.

R. S. Wiener, L. M. Schwartz, S. Woloshin, and H. G. Welch, “Population-based risk for complications after transthoracic needle lung biopsy of a pulmonary nodule: an analysis of discharge records,” Ann. Intern. Med. 155(3), 137–144 (2011).
[Crossref] [PubMed]

Scolaro, L.

Seo, J. S.

W. J. Lee, S. Chong, J. S. Seo, and H. J. Shim, “Transthoracic fine-needle aspiration biopsy of the lungs using a C-arm cone-beam CT system: diagnostic accuracy and post-procedural complications,” Br. J. Radiol. 85(1014), e217–e222 (2012).
[Crossref] [PubMed]

Shaipanich, T.

H. Pahlevaninezhad, A. M. D. Lee, T. Shaipanich, R. Raizada, L. Cahill, G. Hohert, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography,” Biomed. Opt. Express 5(9), 2978–2987 (2014).
[Crossref] [PubMed]

A. McWilliams, T. Shaipanich, and S. Lam, “Fluorescence and navigational bronchoscopy,” Thorac. Surg. Clin. 23(2), 153–161 (2013).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Shim, H. J.

W. J. Lee, S. Chong, J. S. Seo, and H. J. Shim, “Transthoracic fine-needle aspiration biopsy of the lungs using a C-arm cone-beam CT system: diagnostic accuracy and post-procedural complications,” Br. J. Radiol. 85(1014), e217–e222 (2012).
[Crossref] [PubMed]

Shishkov, M.

Silvestri, G. A.

J. S. Wang Memoli, P. J. Nietert, and G. A. Silvestri, “Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule,” Chest 142(2), 385–393 (2012).
[Crossref] [PubMed]

Southern, J. F.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[Crossref] [PubMed]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical Biopsy and Imaging Using Optical Coherence Tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref] [PubMed]

Standish, B.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Steinfort, D. P.

J. H. Tay, L. Irving, P. Antippa, and D. P. Steinfort, “Radial probe endobronchial ultrasound: factors influencing visualization yield of peripheral pulmonary lesions,” Respirology 18(1), 185–190 (2013).
[Crossref] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Suter, M. J.

L. P. Hariri, M. Mino-Kenudson, M. Lanuti, A. J. Miller, E. J. Mark, and M. J. Suter, “Diagnosing lung carcinomas with optical coherence tomography,” Ann. Am. Thorac. Soc. 12(2), 193–201 (2015).
[Crossref] [PubMed]

L. P. Hariri, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. D. Medoff, A. D. Luster, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology,” Chest 143(1), 64–74 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. B. Applegate, M. M. Kenudson, E. J. Mark, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation,” J. Vis. Exp. 71, 3855 (2013).

L. P. Hariri, M. Mino-Kenudson, M. B. Applegate, E. J. Mark, G. J. Tearney, M. Lanuti, C. L. Channick, A. Chee, and M. J. Suter, “Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography,” Chest 144(4), 1261–1268 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. Villiger, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. E. Bouma, and M. J. Suter, “Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy,” Am. J. Respir. Crit. Care Med. 187(2), 125–129 (2013).
[Crossref] [PubMed]

K. M. Tan, M. Shishkov, A. Chee, M. B. Applegate, B. E. Bouma, and M. J. Suter, “Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance,” Biomed. Opt. Express 3(8), 1947–1954 (2012).
[Crossref] [PubMed]

Swanson, E. A.

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical Biopsy and Imaging Using Optical Coherence Tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Szabo, E.

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

Tan, K. M.

Tay, J. H.

J. H. Tay, L. Irving, P. Antippa, and D. P. Steinfort, “Radial probe endobronchial ultrasound: factors influencing visualization yield of peripheral pulmonary lesions,” Respirology 18(1), 185–190 (2013).
[Crossref] [PubMed]

Tearney, G. J.

L. P. Hariri, M. Mino-Kenudson, M. B. Applegate, E. J. Mark, G. J. Tearney, M. Lanuti, C. L. Channick, A. Chee, and M. J. Suter, “Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography,” Chest 144(4), 1261–1268 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. B. Applegate, M. M. Kenudson, E. J. Mark, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation,” J. Vis. Exp. 71, 3855 (2013).

L. P. Hariri, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. D. Medoff, A. D. Luster, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology,” Chest 143(1), 64–74 (2013).
[Crossref] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[Crossref] [PubMed]

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical Biopsy and Imaging Using Optical Coherence Tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref] [PubMed]

Unger, M.

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

Villiger, M.

L. P. Hariri, M. Villiger, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. E. Bouma, and M. J. Suter, “Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy,” Am. J. Respir. Crit. Care Med. 187(2), 125–129 (2013).
[Crossref] [PubMed]

Vitkin, A. I.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Wang Memoli, J. S.

J. S. Wang Memoli, P. J. Nietert, and G. A. Silvestri, “Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule,” Chest 142(2), 385–393 (2012).
[Crossref] [PubMed]

Welch, H. G.

R. S. Wiener, L. M. Schwartz, S. Woloshin, and H. G. Welch, “Population-based risk for complications after transthoracic needle lung biopsy of a pulmonary nodule: an analysis of discharge records,” Ann. Intern. Med. 155(3), 137–144 (2011).
[Crossref] [PubMed]

Wiener, R. S.

R. S. Wiener, L. M. Schwartz, S. Woloshin, and H. G. Welch, “Population-based risk for complications after transthoracic needle lung biopsy of a pulmonary nodule: an analysis of discharge records,” Ann. Intern. Med. 155(3), 137–144 (2011).
[Crossref] [PubMed]

Woloshin, S.

R. S. Wiener, L. M. Schwartz, S. Woloshin, and H. G. Welch, “Population-based risk for complications after transthoracic needle lung biopsy of a pulmonary nodule: an analysis of discharge records,” Ann. Intern. Med. 155(3), 137–144 (2011).
[Crossref] [PubMed]

Yang, V.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Yang, V. X. D.

H. Pahlevaninezhad, A. M. D. Lee, T. Shaipanich, R. Raizada, L. Cahill, G. Hohert, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography,” Biomed. Opt. Express 5(9), 2978–2987 (2014).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Yang, X.

Yeoh, G. C.

Am. J. Respir. Crit. Care Med. (1)

L. P. Hariri, M. Villiger, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. E. Bouma, and M. J. Suter, “Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy,” Am. J. Respir. Crit. Care Med. 187(2), 125–129 (2013).
[Crossref] [PubMed]

Ann. Am. Thorac. Soc. (2)

L. P. Hariri, M. Mino-Kenudson, M. Lanuti, A. J. Miller, E. J. Mark, and M. J. Suter, “Diagnosing lung carcinomas with optical coherence tomography,” Ann. Am. Thorac. Soc. 12(2), 193–201 (2015).
[Crossref] [PubMed]

A. Chen, P. Chenna, A. Loiselle, J. Massoni, M. Mayse, and D. Misselhorn, “Radial probe endobronchial ultrasound for peripheral pulmonary lesions. A 5-year institutional experience,” Ann. Am. Thorac. Soc. 11(4), 578–582 (2014).
[Crossref] [PubMed]

Ann. Intern. Med. (1)

R. S. Wiener, L. M. Schwartz, S. Woloshin, and H. G. Welch, “Population-based risk for complications after transthoracic needle lung biopsy of a pulmonary nodule: an analysis of discharge records,” Ann. Intern. Med. 155(3), 137–144 (2011).
[Crossref] [PubMed]

Biomed. Opt. Express (3)

Br. J. Radiol. (1)

W. J. Lee, S. Chong, J. S. Seo, and H. J. Shim, “Transthoracic fine-needle aspiration biopsy of the lungs using a C-arm cone-beam CT system: diagnostic accuracy and post-procedural complications,” Br. J. Radiol. 85(1014), e217–e222 (2012).
[Crossref] [PubMed]

Chest (4)

J. S. Wang Memoli, P. J. Nietert, and G. A. Silvestri, “Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule,” Chest 142(2), 385–393 (2012).
[Crossref] [PubMed]

S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, “Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy,” Chest 113(3), 696–702 (1998).
[Crossref] [PubMed]

L. P. Hariri, M. B. Applegate, M. Mino-Kenudson, E. J. Mark, B. D. Medoff, A. D. Luster, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology,” Chest 143(1), 64–74 (2013).
[Crossref] [PubMed]

L. P. Hariri, M. Mino-Kenudson, M. B. Applegate, E. J. Mark, G. J. Tearney, M. Lanuti, C. L. Channick, A. Chee, and M. J. Suter, “Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography,” Chest 144(4), 1261–1268 (2013).
[Crossref] [PubMed]

Clin. Cancer Res. (2)

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

S. Lam, J. C. leRiche, A. McWilliams, C. Macaulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, and A. Gazdar, “A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium,” Clin. Cancer Res. 10(19), 6502–6511 (2004).
[Crossref] [PubMed]

J. Biomed. Opt. (2)

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

B. C. Quirk, R. A. McLaughlin, A. Curatolo, R. W. Kirk, P. B. Noble, and D. D. Sampson, “In situ imaging of lung alveoli with an optical coherence tomography needle probe,” J. Biomed. Opt. 16(3), 036009 (2011).
[Crossref] [PubMed]

J. Vis. Exp. (1)

L. P. Hariri, M. B. Applegate, M. M. Kenudson, E. J. Mark, B. E. Bouma, G. J. Tearney, and M. J. Suter, “Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation,” J. Vis. Exp. 71, 3855 (2013).

Lasers Surg. Med. (1)

J. Hung, S. Lam, J. C. LeRiche, and B. Palcic, “Autofluorescence of normal and malignant bronchial tissue,” Lasers Surg. Med. 11(2), 99–105 (1991).
[Crossref] [PubMed]

Nat. Med. (1)

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, “Optical Biopsy and Imaging Using Optical Coherence Tomography,” Nat. Med. 1(9), 970–972 (1995).
[Crossref] [PubMed]

Nature (1)

P. Carmeliet and R. K. Jain, “Angiogenesis in cancer and other diseases,” Nature 407(6801), 249–257 (2000).
[Crossref] [PubMed]

Oncologist (2)

S. K. Carter, “Clinical strategy for the development of angiogenesis inhibitors,” Oncologist 5(90001Suppl 1), 51–54 (2000).
[Crossref] [PubMed]

T. C. Kennedy, S. Lam, and F. R. Hirsch, “Review of recent advances in fluorescence bronchoscopy in early localization of central airway lung cancer,” Oncologist 6(3), 257–262 (2001).
[Crossref] [PubMed]

Opt. Lett. (1)

Respirology (1)

J. H. Tay, L. Irving, P. Antippa, and D. P. Steinfort, “Radial probe endobronchial ultrasound: factors influencing visualization yield of peripheral pulmonary lesions,” Respirology 18(1), 185–190 (2013).
[Crossref] [PubMed]

Science (2)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[Crossref] [PubMed]

Thorac. Surg. Clin. (1)

A. McWilliams, T. Shaipanich, and S. Lam, “Fluorescence and navigational bronchoscopy,” Thorac. Surg. Clin. 23(2), 153–161 (2013).
[Crossref] [PubMed]

Other (1)

M. K. Gould, J. Fletcher, M. D. Iannettoni, W. R. Lynch, D. E. Midthun, D. P. Naidich, and D. E. Ost, “Evaluation of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition)”. Chest, 132(3 Suppl): p. 108S–130S (2007).

Supplementary Material (2)

NameDescription
» Visualization 1: AVI (33054 KB)      Full pull-back movie
» Visualization 2: AVI (38226 KB)      Full pull-back movie

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Figures (5)

Fig. 1
Fig. 1

OCT-AFI image presentation: (a) coordinate system defined with respect to the catheter tip, (b) OCT-AFI frames along the pullback presented in polar coordinates, en face AFI z-θ image, and (d) an OCT-AFI frame presented in Cartesian coordinates. Scale-bars are 1mm.

Fig. 2
Fig. 2

Tumor detection by OCT-AFI: (a) A nodule accessible through LB9b detected in CT-scan, (b) white-light image of LB9a and LB9b being imaged by OCT-AFI, (c) R-EBUS image of the nodule, (d, e) AF z-θ maps of the normal (LB9a) and target (LB9b) airways, respectively, the airway images are oriented distally to proximally top to bottom, (d1-d3, e1-e3) cross-sectional OCT-AFI images in the polar coordinates (r, θ) corresponding to the red dashed lines along the scans of the normal and target airways, respectively, and (f) H&E image of the biopsy sample collected from LB9b. * indicate suspicious area in the AF image (e) and arrows indicate epithelial thickening and invasive tumor in (e1) and (e2), respectively. Scale-bars are 1mm.

Fig. 3
Fig. 3

Vascular network visualization by AFI with confirmation by DOCT: (a, b) AF z-θ maps of pullbacks from airways RB4b and RB2a, (a1-4, b1-4) cross-sectional DOCT-AFI frames in polar coordinates (r, θ) corresponding to the red dashed lines along the pullbacks. ► indicate vessel locations. Scale-bars are 1mm.

Fig. 4
Fig. 4

Vascular network visualization by AFI without OCT Doppler contrast: (a, b) AF z-θ maps of pullbacks from airway RB4 and RB3, (a1-4, b1-4) cross-sectional OCT-AFI in polar coordinates (r, θ) corresponding to the red dashed lines along pullbacks. Supplement files Visualization 1 and Visualization 2 include full OCT-AFI pullback scans of (a) and (b). ► indicate vessel locations. Scale-bars are 1mm.

Fig. 5
Fig. 5

Differentiation of large blood vessels from nodules by DOCT-AFI: (a) a CT-scan showing a nodule in LB4a, (b) R-EBUS image of the nodule, (c) AF z-θ map of a pullback from the same airway site, (c1-2) cross-sectional DOCT-AFI in Cartesian coordinates corresponding to the red dashed lines along the pullback. R-EBUS and DOCT-AFI are referenced with respect to the end of the guide sheath. ► indicates vessel location. Scale-bars are 1mm.

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