Abstract

Intraoperative monitoring of tissue oxygen saturation (StO2) has potentially important applications in procedures such as organ transplantation or colorectal surgery, where successful reperfusion affects the viability and integrity of repaired tissues. In this paper a liquid crystal tuneable filter-based multispectral imaging (MSI) laparoscope is described. Motion-induced image misalignments are reduced, using feature-based registration, before regression of the tissue reflectance spectra to calculate relative quantities of oxy- and deoxyhaemoglobin. The laparoscope was validated in vivo, during porcine abdominal surgery, by making parallel MSI and blood gas measurements of the small bowel vasculature. Ischaemic conditions were induced by local occlusion of the mesenteric arcade and monitored using the system. The MSI laparoscope was capable of measuring StO2 over a wide range (30-100%) with a temporal error of ± 7.5%. The imager showed sensitivity to spatial changes in StO2 during dynamic local occlusions, as well as tracking the recovery of tissues post-occlusion.

© 2015 Optical Society of America

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  1. H. Birke-Sorensen, “Detection of postoperative intestinal ischemia in small bowel transplants,” J. Transplant. 2012, 970630 (2012).
    [Crossref] [PubMed]
  2. N. J. Crane, S. W. Huffman, M. Alemozaffar, F. A. Gage, I. W. Levin, and E. A. Elster, “Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model,” J. Biomed. Opt. 18(3), 035001 (2013).
    [Crossref] [PubMed]
  3. A. Alves, Y. Panis, D. Trancart, J.-M. Regimbeau, M. Pocard, and P. Valleur, “Factors associated with clinically significant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients,” World J. Surg. 26(4), 499–502 (2002).
    [Crossref] [PubMed]
  4. A. Matsui, J. H. Winer, R. G. Laurence, and J. V. Frangioni, “Predicting the survival of experimental ischaemic small bowel using intraoperative near-infrared fluorescence angiography,” Br. J. Surg. 98(12), 1725–1734 (2011).
    [Crossref] [PubMed]
  5. G. Lu and B. Fei, “Medical hyperspectral imaging: a review,” J. Biomed. Opt. 19(1), 010901 (2014).
    [Crossref] [PubMed]
  6. M. G. Sowa, J. R. Payette, M. D. Hewko, and H. H. Mantsch, “Visible-near infrared multispectral imaging of the rat dorsal skin flap,” J. Biomed. Opt. 4(4), 474–481 (1999).
    [Crossref] [PubMed]
  7. M. A. Ilias, E. Häggblad, C. Anderson, and E. G. Salerud, “Visible, hyperspectral imaging evaluating the cutaneous response to ultraviolet radiation,” Proc. SPIE 6441, 644103 (2007).
    [Crossref]
  8. S. P. Nighswander-Rempel, R. Anthony Shaw, J. R. Mansfield, M. Hewko, V. V. Kupriyanov, and H. H. Mantsch, “Regional variations in myocardial tissue oxygenation mapped by near-infrared spectroscopic imaging,” J. Mol. Cell. Cardiol. 34(9), 1195–1203 (2002).
    [Crossref] [PubMed]
  9. B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
    [Crossref] [PubMed]
  10. K. J. Zuzak, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide,” Am. J. Physiol. Heart Circ. Physiol. 285(3), H1183–H1189 (2003).
    [Crossref] [PubMed]
  11. J. C. Ramella-Roman and S. A. Mathews, “Spectroscopic measurements of oxygen saturation in the retina,” IEEE Sel. Top. Quantum Electron. 13(6), 1697–1703 (2007).
    [Crossref]
  12. D. Stoyanov, A. Rayshubskiy, and E. Hillman, “Robust registration of multispectral images of the cortical surface in neurosurgery,” in Proceedings of IEEE International Symposium on Biomedical Imaging (IEEE, 2012), pp. 1643–1646.
    [Crossref]
  13. C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
    [Crossref] [PubMed]
  14. S. P. Nighswander-Rempel, R. A. Shaw, V. V. Kupriyanov, J. Rendell, B. Xiang, and H. H. Mantsch, “Mapping tissue oxygenation in the beating heart with near-infrared spectroscopic imaging,” Vib. Spectrosc. 32(1), 85–94 (2003).
    [Crossref]
  15. K. J. Zuzak, M. D. Schaeberle, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique,” Circulation 104(24), 2905–2910 (2001).
    [Crossref] [PubMed]
  16. K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
    [Crossref] [PubMed]
  17. L. L. Randeberg, E. L. P. Larsen, and L. O. Svaasand, “Characterization of vascular structures and skin bruises using hyperspectral imaging, image analysis and diffusion theory,” J. Biophotonics 3(1-2), 53–65 (2010).
    [Crossref] [PubMed]
  18. H. L. Fu, B. Yu, J. Y. Lo, G. M. Palmer, T. F. Kuech, and N. Ramanujam, “A low-cost, portable, and quantitative spectral imaging system for application to biological tissues,” Opt. Express 18(12), 12630–12645 (2010).
    [Crossref] [PubMed]
  19. S. Wirkert, N. T. Clancy, D. Stoyanov, S. Arya, G. B. Hanna, H.-P. Schlemmer, P. Sauer, D. S. Elson, and L. Maier-Hein, “Endoscopic Sheffield index for unsupervised in vivo spectral band selection,” in Computer-Assisted and Robotic Endoscopy (Springer, 2014), pp. 110–120.
  20. S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
    [Crossref] [PubMed]
  21. K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
    [Crossref] [PubMed]
  22. N. T. Clancy, V. Sauvage, S. Saso, D. Stoyanov, D. J. Corless, M. Boyd, D. E. Noakes, G.-Z. Yang, S. Ghaem-Maghami, J. R. Smith, and D. S. Elson, “Registration and analysis of multispectral images acquired during uterine transplantation surgery,” in Biomedical Optics and 3-D Imaging, OSA Technical Digest (Optical Society of America, 2012), paper. BSu3A.73.
  23. N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
    [Crossref]
  24. X. Du, N. T. Clancy, S. Arya, G. B. Hanna, J. Kelly, D. S. Elson, and D. Stoyanov, “Robust surface tracking combining features, intensity and illumination compensation,” Int. J. CARS (2015, in press).
  25. S. A. Prahl, “Tabulated molar extinction coefficient for hemoglobin in water,” http://omlc.ogi.edu/spectra/hemoglobin/summary.html , Accessed June, 2009.
  26. P. Verwaerde, C. Malet, M. Lagente, F. de la Farge, and J. P. Braun, “The accuracy of the i-STAT portable analyser for measuring blood gases and pH in whole-blood samples from dogs,” Res. Vet. Sci. 73(1), 71–75 (2002).
    [Crossref] [PubMed]
  27. S. L. Jacques, “Optical properties of biological tissues: a review,” Phys. Med. Biol. 58(11), R37–R61 (2013).
    [Crossref] [PubMed]
  28. M. Kohl, U. Lindauer, G. Royl, M. Kühl, L. Gold, A. Villringer, and U. Dirnagl, “Physical model for the spectroscopic analysis of cortical intrinsic optical signals,” Phys. Med. Biol. 45(12), 3749–3764 (2000).
    [Crossref] [PubMed]
  29. J. Rosenberg, W. E. Dirkes, and H. Kehlet, “Episodic arterial oxygen desaturation and heart rate variations following major abdominal surgery,” Br. J. Anaesth. 63(6), 651–654 (1989).
    [Crossref] [PubMed]
  30. L. J. Hirst, G. A. Ford, G. J. Gibson, and J. A. Wilson, “Swallow-induced alterations in breathing in normal older people,” Dysphagia 17(2), 152–161 (2002).
    [Crossref] [PubMed]
  31. Z. A. Awan, E. Häggblad, T. Wester, M. S. Kvernebo, P. S. Halvorsen, and K. Kvernebo, “Diffuse reflectance spectroscopy: systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation,” Microvasc. Res. 81(3), 245–251 (2011).
    [Crossref] [PubMed]

2014 (2)

G. Lu and B. Fei, “Medical hyperspectral imaging: a review,” J. Biomed. Opt. 19(1), 010901 (2014).
[Crossref] [PubMed]

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

2013 (2)

S. L. Jacques, “Optical properties of biological tissues: a review,” Phys. Med. Biol. 58(11), R37–R61 (2013).
[Crossref] [PubMed]

N. J. Crane, S. W. Huffman, M. Alemozaffar, F. A. Gage, I. W. Levin, and E. A. Elster, “Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model,” J. Biomed. Opt. 18(3), 035001 (2013).
[Crossref] [PubMed]

2012 (1)

H. Birke-Sorensen, “Detection of postoperative intestinal ischemia in small bowel transplants,” J. Transplant. 2012, 970630 (2012).
[Crossref] [PubMed]

2011 (3)

A. Matsui, J. H. Winer, R. G. Laurence, and J. V. Frangioni, “Predicting the survival of experimental ischaemic small bowel using intraoperative near-infrared fluorescence angiography,” Br. J. Surg. 98(12), 1725–1734 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Z. A. Awan, E. Häggblad, T. Wester, M. S. Kvernebo, P. S. Halvorsen, and K. Kvernebo, “Diffuse reflectance spectroscopy: systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation,” Microvasc. Res. 81(3), 245–251 (2011).
[Crossref] [PubMed]

2010 (3)

H. L. Fu, B. Yu, J. Y. Lo, G. M. Palmer, T. F. Kuech, and N. Ramanujam, “A low-cost, portable, and quantitative spectral imaging system for application to biological tissues,” Opt. Express 18(12), 12630–12645 (2010).
[Crossref] [PubMed]

L. L. Randeberg, E. L. P. Larsen, and L. O. Svaasand, “Characterization of vascular structures and skin bruises using hyperspectral imaging, image analysis and diffusion theory,” J. Biophotonics 3(1-2), 53–65 (2010).
[Crossref] [PubMed]

C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
[Crossref] [PubMed]

2007 (3)

K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
[Crossref] [PubMed]

J. C. Ramella-Roman and S. A. Mathews, “Spectroscopic measurements of oxygen saturation in the retina,” IEEE Sel. Top. Quantum Electron. 13(6), 1697–1703 (2007).
[Crossref]

M. A. Ilias, E. Häggblad, C. Anderson, and E. G. Salerud, “Visible, hyperspectral imaging evaluating the cutaneous response to ultraviolet radiation,” Proc. SPIE 6441, 644103 (2007).
[Crossref]

2005 (1)

B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
[Crossref] [PubMed]

2003 (2)

K. J. Zuzak, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide,” Am. J. Physiol. Heart Circ. Physiol. 285(3), H1183–H1189 (2003).
[Crossref] [PubMed]

S. P. Nighswander-Rempel, R. A. Shaw, V. V. Kupriyanov, J. Rendell, B. Xiang, and H. H. Mantsch, “Mapping tissue oxygenation in the beating heart with near-infrared spectroscopic imaging,” Vib. Spectrosc. 32(1), 85–94 (2003).
[Crossref]

2002 (5)

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

S. P. Nighswander-Rempel, R. Anthony Shaw, J. R. Mansfield, M. Hewko, V. V. Kupriyanov, and H. H. Mantsch, “Regional variations in myocardial tissue oxygenation mapped by near-infrared spectroscopic imaging,” J. Mol. Cell. Cardiol. 34(9), 1195–1203 (2002).
[Crossref] [PubMed]

A. Alves, Y. Panis, D. Trancart, J.-M. Regimbeau, M. Pocard, and P. Valleur, “Factors associated with clinically significant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients,” World J. Surg. 26(4), 499–502 (2002).
[Crossref] [PubMed]

L. J. Hirst, G. A. Ford, G. J. Gibson, and J. A. Wilson, “Swallow-induced alterations in breathing in normal older people,” Dysphagia 17(2), 152–161 (2002).
[Crossref] [PubMed]

P. Verwaerde, C. Malet, M. Lagente, F. de la Farge, and J. P. Braun, “The accuracy of the i-STAT portable analyser for measuring blood gases and pH in whole-blood samples from dogs,” Res. Vet. Sci. 73(1), 71–75 (2002).
[Crossref] [PubMed]

2001 (1)

K. J. Zuzak, M. D. Schaeberle, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique,” Circulation 104(24), 2905–2910 (2001).
[Crossref] [PubMed]

2000 (1)

M. Kohl, U. Lindauer, G. Royl, M. Kühl, L. Gold, A. Villringer, and U. Dirnagl, “Physical model for the spectroscopic analysis of cortical intrinsic optical signals,” Phys. Med. Biol. 45(12), 3749–3764 (2000).
[Crossref] [PubMed]

1999 (1)

M. G. Sowa, J. R. Payette, M. D. Hewko, and H. H. Mantsch, “Visible-near infrared multispectral imaging of the rat dorsal skin flap,” J. Biomed. Opt. 4(4), 474–481 (1999).
[Crossref] [PubMed]

1989 (1)

J. Rosenberg, W. E. Dirkes, and H. Kehlet, “Episodic arterial oxygen desaturation and heart rate variations following major abdominal surgery,” Br. J. Anaesth. 63(6), 651–654 (1989).
[Crossref] [PubMed]

Alemozaffar, M.

N. J. Crane, S. W. Huffman, M. Alemozaffar, F. A. Gage, I. W. Levin, and E. A. Elster, “Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model,” J. Biomed. Opt. 18(3), 035001 (2013).
[Crossref] [PubMed]

Alexandrakis, G.

K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
[Crossref] [PubMed]

Alves, A.

A. Alves, Y. Panis, D. Trancart, J.-M. Regimbeau, M. Pocard, and P. Valleur, “Factors associated with clinically significant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients,” World J. Surg. 26(4), 499–502 (2002).
[Crossref] [PubMed]

Anderson, C.

M. A. Ilias, E. Häggblad, C. Anderson, and E. G. Salerud, “Visible, hyperspectral imaging evaluating the cutaneous response to ultraviolet radiation,” Proc. SPIE 6441, 644103 (2007).
[Crossref]

Anthony Shaw, R.

S. P. Nighswander-Rempel, R. Anthony Shaw, J. R. Mansfield, M. Hewko, V. V. Kupriyanov, and H. H. Mantsch, “Regional variations in myocardial tissue oxygenation mapped by near-infrared spectroscopic imaging,” J. Mol. Cell. Cardiol. 34(9), 1195–1203 (2002).
[Crossref] [PubMed]

Ashitate, Y.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Awan, Z. A.

Z. A. Awan, E. Häggblad, T. Wester, M. S. Kvernebo, P. S. Halvorsen, and K. Kvernebo, “Diffuse reflectance spectroscopy: systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation,” Microvasc. Res. 81(3), 245–251 (2011).
[Crossref] [PubMed]

Behbehani, K.

K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
[Crossref] [PubMed]

Birke-Sorensen, H.

H. Birke-Sorensen, “Detection of postoperative intestinal ischemia in small bowel transplants,” J. Transplant. 2012, 970630 (2012).
[Crossref] [PubMed]

Boyd, M.

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

Braun, J. P.

P. Verwaerde, C. Malet, M. Lagente, F. de la Farge, and J. P. Braun, “The accuracy of the i-STAT portable analyser for measuring blood gases and pH in whole-blood samples from dogs,” Res. Vet. Sci. 73(1), 71–75 (2002).
[Crossref] [PubMed]

Cadeddu, J. A.

C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
[Crossref] [PubMed]

Cannon, R. O. I.

K. J. Zuzak, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide,” Am. J. Physiol. Heart Circ. Physiol. 285(3), H1183–H1189 (2003).
[Crossref] [PubMed]

K. J. Zuzak, M. D. Schaeberle, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique,” Circulation 104(24), 2905–2910 (2001).
[Crossref] [PubMed]

Cao, Y.

B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
[Crossref] [PubMed]

Clancy, N. T.

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

Corless, D. J.

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

Crane, N. J.

N. J. Crane, S. W. Huffman, M. Alemozaffar, F. A. Gage, I. W. Levin, and E. A. Elster, “Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model,” J. Biomed. Opt. 18(3), 035001 (2013).
[Crossref] [PubMed]

Cuccia, D. J.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

de la Farge, F.

P. Verwaerde, C. Malet, M. Lagente, F. de la Farge, and J. P. Braun, “The accuracy of the i-STAT portable analyser for measuring blood gases and pH in whole-blood samples from dogs,” Res. Vet. Sci. 73(1), 71–75 (2002).
[Crossref] [PubMed]

Dewhirst, M. W.

B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
[Crossref] [PubMed]

Dirkes, W. E.

J. Rosenberg, W. E. Dirkes, and H. Kehlet, “Episodic arterial oxygen desaturation and heart rate variations following major abdominal surgery,” Br. J. Anaesth. 63(6), 651–654 (1989).
[Crossref] [PubMed]

Dirnagl, U.

M. Kohl, U. Lindauer, G. Royl, M. Kühl, L. Gold, A. Villringer, and U. Dirnagl, “Physical model for the spectroscopic analysis of cortical intrinsic optical signals,” Phys. Med. Biol. 45(12), 3749–3764 (2000).
[Crossref] [PubMed]

Donovan, O.

B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
[Crossref] [PubMed]

Durkin, A. J.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Durr, N. J.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Elson, D. S.

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

Elster, E. A.

N. J. Crane, S. W. Huffman, M. Alemozaffar, F. A. Gage, I. W. Levin, and E. A. Elster, “Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model,” J. Biomed. Opt. 18(3), 035001 (2013).
[Crossref] [PubMed]

Fei, B.

G. Lu and B. Fei, “Medical hyperspectral imaging: a review,” J. Biomed. Opt. 19(1), 010901 (2014).
[Crossref] [PubMed]

Ford, G. A.

L. J. Hirst, G. A. Ford, G. J. Gibson, and J. A. Wilson, “Swallow-induced alterations in breathing in normal older people,” Dysphagia 17(2), 152–161 (2002).
[Crossref] [PubMed]

Francis, R. P.

C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
[Crossref] [PubMed]

Frangioni, J. V.

A. Matsui, J. H. Winer, R. G. Laurence, and J. V. Frangioni, “Predicting the survival of experimental ischaemic small bowel using intraoperative near-infrared fluorescence angiography,” Br. J. Surg. 98(12), 1725–1734 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Fu, H. L.

Gage, F. A.

N. J. Crane, S. W. Huffman, M. Alemozaffar, F. A. Gage, I. W. Levin, and E. A. Elster, “Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model,” J. Biomed. Opt. 18(3), 035001 (2013).
[Crossref] [PubMed]

Ghaem-Maghami, S.

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

Gibson, G. J.

L. J. Hirst, G. A. Ford, G. J. Gibson, and J. A. Wilson, “Swallow-induced alterations in breathing in normal older people,” Dysphagia 17(2), 152–161 (2002).
[Crossref] [PubMed]

Gioux, S.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Gladwin, M. T.

K. J. Zuzak, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide,” Am. J. Physiol. Heart Circ. Physiol. 285(3), H1183–H1189 (2003).
[Crossref] [PubMed]

K. J. Zuzak, M. D. Schaeberle, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique,” Circulation 104(24), 2905–2910 (2001).
[Crossref] [PubMed]

Gold, L.

M. Kohl, U. Lindauer, G. Royl, M. Kühl, L. Gold, A. Villringer, and U. Dirnagl, “Physical model for the spectroscopic analysis of cortical intrinsic optical signals,” Phys. Med. Biol. 45(12), 3749–3764 (2000).
[Crossref] [PubMed]

Häggblad, E.

Z. A. Awan, E. Häggblad, T. Wester, M. S. Kvernebo, P. S. Halvorsen, and K. Kvernebo, “Diffuse reflectance spectroscopy: systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation,” Microvasc. Res. 81(3), 245–251 (2011).
[Crossref] [PubMed]

M. A. Ilias, E. Häggblad, C. Anderson, and E. G. Salerud, “Visible, hyperspectral imaging evaluating the cutaneous response to ultraviolet radiation,” Proc. SPIE 6441, 644103 (2007).
[Crossref]

Halvorsen, P. S.

Z. A. Awan, E. Häggblad, T. Wester, M. S. Kvernebo, P. S. Halvorsen, and K. Kvernebo, “Diffuse reflectance spectroscopy: systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation,” Microvasc. Res. 81(3), 245–251 (2011).
[Crossref] [PubMed]

Hawkins, D.

K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
[Crossref] [PubMed]

Hawkins, D. L.

C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
[Crossref] [PubMed]

Hewko, M.

S. P. Nighswander-Rempel, R. Anthony Shaw, J. R. Mansfield, M. Hewko, V. V. Kupriyanov, and H. H. Mantsch, “Regional variations in myocardial tissue oxygenation mapped by near-infrared spectroscopic imaging,” J. Mol. Cell. Cardiol. 34(9), 1195–1203 (2002).
[Crossref] [PubMed]

Hewko, M. D.

M. G. Sowa, J. R. Payette, M. D. Hewko, and H. H. Mantsch, “Visible-near infrared multispectral imaging of the rat dorsal skin flap,” J. Biomed. Opt. 4(4), 474–481 (1999).
[Crossref] [PubMed]

Hillman, E.

D. Stoyanov, A. Rayshubskiy, and E. Hillman, “Robust registration of multispectral images of the cortical surface in neurosurgery,” in Proceedings of IEEE International Symposium on Biomedical Imaging (IEEE, 2012), pp. 1643–1646.
[Crossref]

Hirst, L. J.

L. J. Hirst, G. A. Ford, G. J. Gibson, and J. A. Wilson, “Swallow-induced alterations in breathing in normal older people,” Dysphagia 17(2), 152–161 (2002).
[Crossref] [PubMed]

Huffman, S. W.

N. J. Crane, S. W. Huffman, M. Alemozaffar, F. A. Gage, I. W. Levin, and E. A. Elster, “Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model,” J. Biomed. Opt. 18(3), 035001 (2013).
[Crossref] [PubMed]

Ilias, M. A.

M. A. Ilias, E. Häggblad, C. Anderson, and E. G. Salerud, “Visible, hyperspectral imaging evaluating the cutaneous response to ultraviolet radiation,” Proc. SPIE 6441, 644103 (2007).
[Crossref]

Jacques, S. L.

S. L. Jacques, “Optical properties of biological tissues: a review,” Phys. Med. Biol. 58(11), R37–R61 (2013).
[Crossref] [PubMed]

Kehlet, H.

J. Rosenberg, W. E. Dirkes, and H. Kehlet, “Episodic arterial oxygen desaturation and heart rate variations following major abdominal surgery,” Br. J. Anaesth. 63(6), 651–654 (1989).
[Crossref] [PubMed]

Kelly, E.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Kohl, M.

M. Kohl, U. Lindauer, G. Royl, M. Kühl, L. Gold, A. Villringer, and U. Dirnagl, “Physical model for the spectroscopic analysis of cortical intrinsic optical signals,” Phys. Med. Biol. 45(12), 3749–3764 (2000).
[Crossref] [PubMed]

Kuech, T. F.

Kühl, M.

M. Kohl, U. Lindauer, G. Royl, M. Kühl, L. Gold, A. Villringer, and U. Dirnagl, “Physical model for the spectroscopic analysis of cortical intrinsic optical signals,” Phys. Med. Biol. 45(12), 3749–3764 (2000).
[Crossref] [PubMed]

Kupriyanov, V. V.

S. P. Nighswander-Rempel, R. A. Shaw, V. V. Kupriyanov, J. Rendell, B. Xiang, and H. H. Mantsch, “Mapping tissue oxygenation in the beating heart with near-infrared spectroscopic imaging,” Vib. Spectrosc. 32(1), 85–94 (2003).
[Crossref]

S. P. Nighswander-Rempel, R. Anthony Shaw, J. R. Mansfield, M. Hewko, V. V. Kupriyanov, and H. H. Mantsch, “Regional variations in myocardial tissue oxygenation mapped by near-infrared spectroscopic imaging,” J. Mol. Cell. Cardiol. 34(9), 1195–1203 (2002).
[Crossref] [PubMed]

Kvernebo, K.

Z. A. Awan, E. Häggblad, T. Wester, M. S. Kvernebo, P. S. Halvorsen, and K. Kvernebo, “Diffuse reflectance spectroscopy: systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation,” Microvasc. Res. 81(3), 245–251 (2011).
[Crossref] [PubMed]

Kvernebo, M. S.

Z. A. Awan, E. Häggblad, T. Wester, M. S. Kvernebo, P. S. Halvorsen, and K. Kvernebo, “Diffuse reflectance spectroscopy: systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation,” Microvasc. Res. 81(3), 245–251 (2011).
[Crossref] [PubMed]

Lagente, M.

P. Verwaerde, C. Malet, M. Lagente, F. de la Farge, and J. P. Braun, “The accuracy of the i-STAT portable analyser for measuring blood gases and pH in whole-blood samples from dogs,” Res. Vet. Sci. 73(1), 71–75 (2002).
[Crossref] [PubMed]

Larsen, E. L. P.

L. L. Randeberg, E. L. P. Larsen, and L. O. Svaasand, “Characterization of vascular structures and skin bruises using hyperspectral imaging, image analysis and diffusion theory,” J. Biophotonics 3(1-2), 53–65 (2010).
[Crossref] [PubMed]

Laurence, R. G.

A. Matsui, J. H. Winer, R. G. Laurence, and J. V. Frangioni, “Predicting the survival of experimental ischaemic small bowel using intraoperative near-infrared fluorescence angiography,” Br. J. Surg. 98(12), 1725–1734 (2011).
[Crossref] [PubMed]

Lee, B. T.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Levin, I. W.

N. J. Crane, S. W. Huffman, M. Alemozaffar, F. A. Gage, I. W. Levin, and E. A. Elster, “Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model,” J. Biomed. Opt. 18(3), 035001 (2013).
[Crossref] [PubMed]

K. J. Zuzak, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide,” Am. J. Physiol. Heart Circ. Physiol. 285(3), H1183–H1189 (2003).
[Crossref] [PubMed]

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

K. J. Zuzak, M. D. Schaeberle, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique,” Circulation 104(24), 2905–2910 (2001).
[Crossref] [PubMed]

Lewis, E. N.

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

Lin, S. J.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Lindauer, U.

M. Kohl, U. Lindauer, G. Royl, M. Kühl, L. Gold, A. Villringer, and U. Dirnagl, “Physical model for the spectroscopic analysis of cortical intrinsic optical signals,” Phys. Med. Biol. 45(12), 3749–3764 (2000).
[Crossref] [PubMed]

Litorja, M.

C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
[Crossref] [PubMed]

Livingston, E. H.

K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
[Crossref] [PubMed]

Lo, J. Y.

Lu, G.

G. Lu and B. Fei, “Medical hyperspectral imaging: a review,” J. Biomed. Opt. 19(1), 010901 (2014).
[Crossref] [PubMed]

Malet, C.

P. Verwaerde, C. Malet, M. Lagente, F. de la Farge, and J. P. Braun, “The accuracy of the i-STAT portable analyser for measuring blood gases and pH in whole-blood samples from dogs,” Res. Vet. Sci. 73(1), 71–75 (2002).
[Crossref] [PubMed]

Mansfield, J. R.

S. P. Nighswander-Rempel, R. Anthony Shaw, J. R. Mansfield, M. Hewko, V. V. Kupriyanov, and H. H. Mantsch, “Regional variations in myocardial tissue oxygenation mapped by near-infrared spectroscopic imaging,” J. Mol. Cell. Cardiol. 34(9), 1195–1203 (2002).
[Crossref] [PubMed]

Mantsch, H. H.

S. P. Nighswander-Rempel, R. A. Shaw, V. V. Kupriyanov, J. Rendell, B. Xiang, and H. H. Mantsch, “Mapping tissue oxygenation in the beating heart with near-infrared spectroscopic imaging,” Vib. Spectrosc. 32(1), 85–94 (2003).
[Crossref]

S. P. Nighswander-Rempel, R. Anthony Shaw, J. R. Mansfield, M. Hewko, V. V. Kupriyanov, and H. H. Mantsch, “Regional variations in myocardial tissue oxygenation mapped by near-infrared spectroscopic imaging,” J. Mol. Cell. Cardiol. 34(9), 1195–1203 (2002).
[Crossref] [PubMed]

M. G. Sowa, J. R. Payette, M. D. Hewko, and H. H. Mantsch, “Visible-near infrared multispectral imaging of the rat dorsal skin flap,” J. Biomed. Opt. 4(4), 474–481 (1999).
[Crossref] [PubMed]

Mathews, S. A.

J. C. Ramella-Roman and S. A. Mathews, “Spectroscopic measurements of oxygen saturation in the retina,” IEEE Sel. Top. Quantum Electron. 13(6), 1697–1703 (2007).
[Crossref]

Matsui, A.

A. Matsui, J. H. Winer, R. G. Laurence, and J. V. Frangioni, “Predicting the survival of experimental ischaemic small bowel using intraoperative near-infrared fluorescence angiography,” Br. J. Surg. 98(12), 1725–1734 (2011).
[Crossref] [PubMed]

Mazhar, A.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Moeller, B. J.

B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
[Crossref] [PubMed]

Moffitt, L. A.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Naik, S. C.

K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
[Crossref] [PubMed]

Nighswander-Rempel, S. P.

S. P. Nighswander-Rempel, R. A. Shaw, V. V. Kupriyanov, J. Rendell, B. Xiang, and H. H. Mantsch, “Mapping tissue oxygenation in the beating heart with near-infrared spectroscopic imaging,” Vib. Spectrosc. 32(1), 85–94 (2003).
[Crossref]

S. P. Nighswander-Rempel, R. Anthony Shaw, J. R. Mansfield, M. Hewko, V. V. Kupriyanov, and H. H. Mantsch, “Regional variations in myocardial tissue oxygenation mapped by near-infrared spectroscopic imaging,” J. Mol. Cell. Cardiol. 34(9), 1195–1203 (2002).
[Crossref] [PubMed]

Noakes, D. E.

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

Oketokoun, R.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Palmer, G. M.

Panis, Y.

A. Alves, Y. Panis, D. Trancart, J.-M. Regimbeau, M. Pocard, and P. Valleur, “Factors associated with clinically significant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients,” World J. Surg. 26(4), 499–502 (2002).
[Crossref] [PubMed]

Payette, J. R.

M. G. Sowa, J. R. Payette, M. D. Hewko, and H. H. Mantsch, “Visible-near infrared multispectral imaging of the rat dorsal skin flap,” J. Biomed. Opt. 4(4), 474–481 (1999).
[Crossref] [PubMed]

Pearle, M. S.

C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
[Crossref] [PubMed]

Pocard, M.

A. Alves, Y. Panis, D. Trancart, J.-M. Regimbeau, M. Pocard, and P. Valleur, “Factors associated with clinically significant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients,” World J. Surg. 26(4), 499–502 (2002).
[Crossref] [PubMed]

Ramanujam, N.

Ramella-Roman, J. C.

J. C. Ramella-Roman and S. A. Mathews, “Spectroscopic measurements of oxygen saturation in the retina,” IEEE Sel. Top. Quantum Electron. 13(6), 1697–1703 (2007).
[Crossref]

Randeberg, L. L.

L. L. Randeberg, E. L. P. Larsen, and L. O. Svaasand, “Characterization of vascular structures and skin bruises using hyperspectral imaging, image analysis and diffusion theory,” J. Biophotonics 3(1-2), 53–65 (2010).
[Crossref] [PubMed]

Rayshubskiy, A.

D. Stoyanov, A. Rayshubskiy, and E. Hillman, “Robust registration of multispectral images of the cortical surface in neurosurgery,” in Proceedings of IEEE International Symposium on Biomedical Imaging (IEEE, 2012), pp. 1643–1646.
[Crossref]

Regimbeau, J.-M.

A. Alves, Y. Panis, D. Trancart, J.-M. Regimbeau, M. Pocard, and P. Valleur, “Factors associated with clinically significant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients,” World J. Surg. 26(4), 499–502 (2002).
[Crossref] [PubMed]

Rendell, J.

S. P. Nighswander-Rempel, R. A. Shaw, V. V. Kupriyanov, J. Rendell, B. Xiang, and H. H. Mantsch, “Mapping tissue oxygenation in the beating heart with near-infrared spectroscopic imaging,” Vib. Spectrosc. 32(1), 85–94 (2003).
[Crossref]

Rosenberg, J.

J. Rosenberg, W. E. Dirkes, and H. Kehlet, “Episodic arterial oxygen desaturation and heart rate variations following major abdominal surgery,” Br. J. Anaesth. 63(6), 651–654 (1989).
[Crossref] [PubMed]

Royl, G.

M. Kohl, U. Lindauer, G. Royl, M. Kühl, L. Gold, A. Villringer, and U. Dirnagl, “Physical model for the spectroscopic analysis of cortical intrinsic optical signals,” Phys. Med. Biol. 45(12), 3749–3764 (2000).
[Crossref] [PubMed]

Salerud, E. G.

M. A. Ilias, E. Häggblad, C. Anderson, and E. G. Salerud, “Visible, hyperspectral imaging evaluating the cutaneous response to ultraviolet radiation,” Proc. SPIE 6441, 644103 (2007).
[Crossref]

Saso, S.

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

Sauvage, V.

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

Schaeberle, M. D.

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

K. J. Zuzak, M. D. Schaeberle, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique,” Circulation 104(24), 2905–2910 (2001).
[Crossref] [PubMed]

Shaw, R. A.

S. P. Nighswander-Rempel, R. A. Shaw, V. V. Kupriyanov, J. Rendell, B. Xiang, and H. H. Mantsch, “Mapping tissue oxygenation in the beating heart with near-infrared spectroscopic imaging,” Vib. Spectrosc. 32(1), 85–94 (2003).
[Crossref]

Smith, A. D.

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

Smith, J.

C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
[Crossref] [PubMed]

Sorg, B. S.

B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
[Crossref] [PubMed]

Sowa, M. G.

M. G. Sowa, J. R. Payette, M. D. Hewko, and H. H. Mantsch, “Visible-near infrared multispectral imaging of the rat dorsal skin flap,” J. Biomed. Opt. 4(4), 474–481 (1999).
[Crossref] [PubMed]

Stockdale, A.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Stoyanov, D.

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

D. Stoyanov, A. Rayshubskiy, and E. Hillman, “Robust registration of multispectral images of the cortical surface in neurosurgery,” in Proceedings of IEEE International Symposium on Biomedical Imaging (IEEE, 2012), pp. 1643–1646.
[Crossref]

Svaasand, L. O.

L. L. Randeberg, E. L. P. Larsen, and L. O. Svaasand, “Characterization of vascular structures and skin bruises using hyperspectral imaging, image analysis and diffusion theory,” J. Biophotonics 3(1-2), 53–65 (2010).
[Crossref] [PubMed]

Terrell, J. D.

C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
[Crossref] [PubMed]

Thum, M.-Y.

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

Tobias, A. M.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Tracy, C. R.

C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
[Crossref] [PubMed]

Trancart, D.

A. Alves, Y. Panis, D. Trancart, J.-M. Regimbeau, M. Pocard, and P. Valleur, “Factors associated with clinically significant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients,” World J. Surg. 26(4), 499–502 (2002).
[Crossref] [PubMed]

Tromberg, B. J.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Valleur, P.

A. Alves, Y. Panis, D. Trancart, J.-M. Regimbeau, M. Pocard, and P. Valleur, “Factors associated with clinically significant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients,” World J. Surg. 26(4), 499–502 (2002).
[Crossref] [PubMed]

Verwaerde, P.

P. Verwaerde, C. Malet, M. Lagente, F. de la Farge, and J. P. Braun, “The accuracy of the i-STAT portable analyser for measuring blood gases and pH in whole-blood samples from dogs,” Res. Vet. Sci. 73(1), 71–75 (2002).
[Crossref] [PubMed]

Villringer, A.

M. Kohl, U. Lindauer, G. Royl, M. Kühl, L. Gold, A. Villringer, and U. Dirnagl, “Physical model for the spectroscopic analysis of cortical intrinsic optical signals,” Phys. Med. Biol. 45(12), 3749–3764 (2000).
[Crossref] [PubMed]

Wehner, E. F.

C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
[Crossref] [PubMed]

Weinmann, M.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Wester, T.

Z. A. Awan, E. Häggblad, T. Wester, M. S. Kvernebo, P. S. Halvorsen, and K. Kvernebo, “Diffuse reflectance spectroscopy: systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation,” Microvasc. Res. 81(3), 245–251 (2011).
[Crossref] [PubMed]

Wilson, J. A.

L. J. Hirst, G. A. Ford, G. J. Gibson, and J. A. Wilson, “Swallow-induced alterations in breathing in normal older people,” Dysphagia 17(2), 152–161 (2002).
[Crossref] [PubMed]

Winer, J. H.

A. Matsui, J. H. Winer, R. G. Laurence, and J. V. Frangioni, “Predicting the survival of experimental ischaemic small bowel using intraoperative near-infrared fluorescence angiography,” Br. J. Surg. 98(12), 1725–1734 (2011).
[Crossref] [PubMed]

Xiang, B.

S. P. Nighswander-Rempel, R. A. Shaw, V. V. Kupriyanov, J. Rendell, B. Xiang, and H. H. Mantsch, “Mapping tissue oxygenation in the beating heart with near-infrared spectroscopic imaging,” Vib. Spectrosc. 32(1), 85–94 (2003).
[Crossref]

Yu, B.

Zuzak, K. J.

C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
[Crossref] [PubMed]

K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
[Crossref] [PubMed]

K. J. Zuzak, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide,” Am. J. Physiol. Heart Circ. Physiol. 285(3), H1183–H1189 (2003).
[Crossref] [PubMed]

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

K. J. Zuzak, M. D. Schaeberle, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique,” Circulation 104(24), 2905–2910 (2001).
[Crossref] [PubMed]

Am. J. Physiol. Heart Circ. Physiol. (1)

K. J. Zuzak, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide,” Am. J. Physiol. Heart Circ. Physiol. 285(3), H1183–H1189 (2003).
[Crossref] [PubMed]

Anal. Chem. (2)

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
[Crossref] [PubMed]

Br. J. Anaesth. (1)

J. Rosenberg, W. E. Dirkes, and H. Kehlet, “Episodic arterial oxygen desaturation and heart rate variations following major abdominal surgery,” Br. J. Anaesth. 63(6), 651–654 (1989).
[Crossref] [PubMed]

Br. J. Surg. (1)

A. Matsui, J. H. Winer, R. G. Laurence, and J. V. Frangioni, “Predicting the survival of experimental ischaemic small bowel using intraoperative near-infrared fluorescence angiography,” Br. J. Surg. 98(12), 1725–1734 (2011).
[Crossref] [PubMed]

Circulation (1)

K. J. Zuzak, M. D. Schaeberle, M. T. Gladwin, R. O. I. Cannon, and I. W. Levin, “Noninvasive determination of spatially resolved and time-resolved tissue perfusion in humans during nitric oxide inhibition and inhalation by use of a visible-reflectance hyperspectral imaging technique,” Circulation 104(24), 2905–2910 (2001).
[Crossref] [PubMed]

Dysphagia (1)

L. J. Hirst, G. A. Ford, G. J. Gibson, and J. A. Wilson, “Swallow-induced alterations in breathing in normal older people,” Dysphagia 17(2), 152–161 (2002).
[Crossref] [PubMed]

IEEE Sel. Top. Quantum Electron. (1)

J. C. Ramella-Roman and S. A. Mathews, “Spectroscopic measurements of oxygen saturation in the retina,” IEEE Sel. Top. Quantum Electron. 13(6), 1697–1703 (2007).
[Crossref]

J. Biomed. Opt. (5)

B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
[Crossref] [PubMed]

G. Lu and B. Fei, “Medical hyperspectral imaging: a review,” J. Biomed. Opt. 19(1), 010901 (2014).
[Crossref] [PubMed]

M. G. Sowa, J. R. Payette, M. D. Hewko, and H. H. Mantsch, “Visible-near infrared multispectral imaging of the rat dorsal skin flap,” J. Biomed. Opt. 4(4), 474–481 (1999).
[Crossref] [PubMed]

N. J. Crane, S. W. Huffman, M. Alemozaffar, F. A. Gage, I. W. Levin, and E. A. Elster, “Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model,” J. Biomed. Opt. 18(3), 035001 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

J. Biophotonics (1)

L. L. Randeberg, E. L. P. Larsen, and L. O. Svaasand, “Characterization of vascular structures and skin bruises using hyperspectral imaging, image analysis and diffusion theory,” J. Biophotonics 3(1-2), 53–65 (2010).
[Crossref] [PubMed]

J. Endourol. (1)

C. R. Tracy, J. D. Terrell, R. P. Francis, E. F. Wehner, J. Smith, M. Litorja, D. L. Hawkins, M. S. Pearle, J. A. Cadeddu, and K. J. Zuzak, “Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion,” J. Endourol. 24(3), 321–325 (2010).
[Crossref] [PubMed]

J. Mol. Cell. Cardiol. (1)

S. P. Nighswander-Rempel, R. Anthony Shaw, J. R. Mansfield, M. Hewko, V. V. Kupriyanov, and H. H. Mantsch, “Regional variations in myocardial tissue oxygenation mapped by near-infrared spectroscopic imaging,” J. Mol. Cell. Cardiol. 34(9), 1195–1203 (2002).
[Crossref] [PubMed]

J. Transplant. (1)

H. Birke-Sorensen, “Detection of postoperative intestinal ischemia in small bowel transplants,” J. Transplant. 2012, 970630 (2012).
[Crossref] [PubMed]

Microvasc. Res. (1)

Z. A. Awan, E. Häggblad, T. Wester, M. S. Kvernebo, P. S. Halvorsen, and K. Kvernebo, “Diffuse reflectance spectroscopy: systemic and microvascular oxygen saturation is linearly correlated and hypoxia leads to increased spatial heterogeneity of microvascular saturation,” Microvasc. Res. 81(3), 245–251 (2011).
[Crossref] [PubMed]

Opt. Express (1)

Phys. Med. Biol. (2)

S. L. Jacques, “Optical properties of biological tissues: a review,” Phys. Med. Biol. 58(11), R37–R61 (2013).
[Crossref] [PubMed]

M. Kohl, U. Lindauer, G. Royl, M. Kühl, L. Gold, A. Villringer, and U. Dirnagl, “Physical model for the spectroscopic analysis of cortical intrinsic optical signals,” Phys. Med. Biol. 45(12), 3749–3764 (2000).
[Crossref] [PubMed]

Proc. SPIE (2)

N. T. Clancy, S. Saso, D. Stoyanov, V. Sauvage, D. J. Corless, M. Boyd, D. E. Noakes, M.-Y. Thum, S. Ghaem-Maghami, A. D. Smith, and D. S. Elson, “Multispectral imaging of organ viability during uterine transplantation surgery,” Proc. SPIE 8935, 893510 (2014).
[Crossref]

M. A. Ilias, E. Häggblad, C. Anderson, and E. G. Salerud, “Visible, hyperspectral imaging evaluating the cutaneous response to ultraviolet radiation,” Proc. SPIE 6441, 644103 (2007).
[Crossref]

Res. Vet. Sci. (1)

P. Verwaerde, C. Malet, M. Lagente, F. de la Farge, and J. P. Braun, “The accuracy of the i-STAT portable analyser for measuring blood gases and pH in whole-blood samples from dogs,” Res. Vet. Sci. 73(1), 71–75 (2002).
[Crossref] [PubMed]

Vib. Spectrosc. (1)

S. P. Nighswander-Rempel, R. A. Shaw, V. V. Kupriyanov, J. Rendell, B. Xiang, and H. H. Mantsch, “Mapping tissue oxygenation in the beating heart with near-infrared spectroscopic imaging,” Vib. Spectrosc. 32(1), 85–94 (2003).
[Crossref]

World J. Surg. (1)

A. Alves, Y. Panis, D. Trancart, J.-M. Regimbeau, M. Pocard, and P. Valleur, “Factors associated with clinically significant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients,” World J. Surg. 26(4), 499–502 (2002).
[Crossref] [PubMed]

Other (5)

D. Stoyanov, A. Rayshubskiy, and E. Hillman, “Robust registration of multispectral images of the cortical surface in neurosurgery,” in Proceedings of IEEE International Symposium on Biomedical Imaging (IEEE, 2012), pp. 1643–1646.
[Crossref]

S. Wirkert, N. T. Clancy, D. Stoyanov, S. Arya, G. B. Hanna, H.-P. Schlemmer, P. Sauer, D. S. Elson, and L. Maier-Hein, “Endoscopic Sheffield index for unsupervised in vivo spectral band selection,” in Computer-Assisted and Robotic Endoscopy (Springer, 2014), pp. 110–120.

X. Du, N. T. Clancy, S. Arya, G. B. Hanna, J. Kelly, D. S. Elson, and D. Stoyanov, “Robust surface tracking combining features, intensity and illumination compensation,” Int. J. CARS (2015, in press).

S. A. Prahl, “Tabulated molar extinction coefficient for hemoglobin in water,” http://omlc.ogi.edu/spectra/hemoglobin/summary.html , Accessed June, 2009.

N. T. Clancy, V. Sauvage, S. Saso, D. Stoyanov, D. J. Corless, M. Boyd, D. E. Noakes, G.-Z. Yang, S. Ghaem-Maghami, J. R. Smith, and D. S. Elson, “Registration and analysis of multispectral images acquired during uterine transplantation surgery,” in Biomedical Optics and 3-D Imaging, OSA Technical Digest (Optical Society of America, 2012), paper. BSu3A.73.

Supplementary Material (3)

NameDescription
» Visualization 1: AVI (2638 KB)      Demonstration of error reduction in processed StO2 images following image registration.
» Visualization 2: AVI (6386 KB)      Variation of small bowel StO2 over time during clamping and unclamping of the mesenteric arcade.
» Visualization 3: AVI (2398 KB)      Variation of small bowel StO2 over time during euthanasia of porcine subject.

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Figures (6)

Fig. 1
Fig. 1 Laparoscopic MSI system. (a) Schematic showing the main constituents, including the 30° laparoscope, liquid crystal tuneable filter, camera and focusing optics. (b) Photograph of the laparoscope mounted on an adjustable arm and connected to the xenon light source via the fibre optic light cable.
Fig. 2
Fig. 2 Oxygen saturation validation. MSI readings were made of the small bowel serosa ((a) RGB, (b) processed StO2 map following motion correction, as shown in Visualization 1), followed by withdrawal of a blood sample (c) from a neighbouring mesenteric vessel. The mean StO2 of the region-of-interest (ROI), indicated by the dashed box, was then calculated. Areas of ischaemia were generated by clamping the mesenteric vessels (d).
Fig. 3
Fig. 3 Temporal and spatial variation. (a) Map of σ tStO2 in a segment of bowel over seven acquisitions. (b) Histogram of σ tStO2 recorded over the entire bowel segment. (c) Spatial standard deviation of StO2 values (σ sStO2) as the ROI size is varied.
Fig. 4
Fig. 4 (a) Plot of mean StO2 from the selected MSI ROI against oxygen saturation in the neighbouring vessel measured by the blood gas analyser. The error bars indicate ± 1 standard deviation (σ) of StO2 values within each ROI. (b) Bland-Altman plot, showing the absolute difference between the MSI and blood gas instruments as a function of their mean value. Horizontal lines indicate the absolute mean difference ± 1.96σ.
Fig. 5
Fig. 5 Variation of StO2 with time (Visualization 2) during successive clamping and release of segments of porcine small bowel. (a) Processed StO2 images of the bowel at each of the five distinct stages during the experiment as clamps (C1 and C2) were applied (‘on’) and released (‘off’). (b) StO2 in a region of interest located in the centre of the bowel segment (white box) in the images shown in (a). The black dashed lines represent time-points for (i) C1 on, (ii) C2 on, (iii) C1 off and (iv) C2 off, while the red dashed line indicates the average baseline saturation.
Fig. 6
Fig. 6 Oxygen saturation following delivery of drugs to euthanise the porcine test subject (a) StO2 maps as a function of time. (b) Mean StO2 of bowel wall ROI (Visualization 3).

Equations (5)

Equations on this page are rendered with MathJax. Learn more.

R(i,j,λ)= I(i,j,λ) I D (i,j,λ) I 0 (λ) I D (λ) ,
A(i,j,λ)=ln( R(i,j,λ) ).
A(i,j,λ)=[Hb O 2 ] ε Hb O 2 (λ)+[Hb] ε Hb (λ)+α,
Hbt=Hb O 2 +Hb; St O 2 = Hb O 2 Hbt .
X F = λ=460 λ=700 I (λ) T F (λ),

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