Abstract

A novel acquisition and processing method that enables real-time, single snapshot of optical properties (SSOP) and 3-dimensional (3D) profile measurements in the spatial frequency domain is described. This method makes use of a dual sinusoidal wave projection pattern permitting to extract the DC and AC components in the frequency domain to recover optical properties as well as the phase for measuring the 3D profile. In this method, the 3D profile is used to correct for the effect of sample’s height and angle and directly obtain profile-corrected absorption and reduced scattering maps from a single acquired image. In this manuscript, the 3D-SSOP method is described and validated on tissue-mimicking phantoms as well as in vivo, in comparison with the standard profile-corrected SFDI (3D-SFDI) method. On average, in comparison with 3D-SFDI method, the 3D-SSOP method allows to recover the profile within 1.2mm and profile-corrected optical properties within 12% for absorption and 6% for reduced scattering over a large field-of-view and in real-time.

© 2015 Optical Society of America

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2015 (1)

T. E. Travis, P. Ghassemi, J. C. Ramella-Roman, N. J. Prindeze, D. W. Paul, L. T. Moffatt, M. H. Jordan, and J. W. Shupp, “A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar,” J. Burn Care Res. 36(1), 77–86 (2015).
[Crossref] [PubMed]

2014 (3)

K. P. Nadeau, A. J. Durkin, and B. J. Tromberg, “Advanced demodulation technique for the extraction of tissue optical properties and structural orientation contrast in the spatial frequency domain,” J. Biomed. Opt. 19(5), 056013 (2014).
[Crossref] [PubMed]

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

A. Ponticorvo, D. M. Burmeister, B. Yang, B. Choi, R. J. Christy, and A. J. Durkin, “Quantitative assessment of graded burn wounds in a porcine model using spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI),” Biomed. Opt. Express 5(10), 3467–3481 (2014).
[Crossref] [PubMed]

2013 (3)

J. Vervandier and S. Gioux, “Single snapshot imaging of optical properties,” Biomed. Opt. Express 4(12), 2938–2944 (2013).
[Crossref] [PubMed]

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res. 15(4), R61 (2013).
[Crossref] [PubMed]

2011 (4)

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

2010 (5)

S. Gioux, H. S. Choi, and J. V. Frangioni, “Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation,” Mol. Imaging 9(5), 237–255 (2010).
[PubMed]

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

S. Bélanger, M. Abran, X. Intes, C. Casanova, and F. Lesage, “Real-time diffuse optical tomography based on structured illumination,” J. Biomed. Opt. 15(1), 016006 (2010).
[Crossref] [PubMed]

C. D’Andrea, N. Ducros, A. Bassi, S. Arridge, and G. Valentini, “Fast 3D optical reconstruction in turbid media using spatially modulated light,” Biomed. Opt. Express 1(2), 471–481 (2010).
[Crossref] [PubMed]

S. Kukreti, A. E. Cerussi, W. Tanamai, D. Hsiang, B. J. Tromberg, and E. Gratton, “Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy,” Radiology 254(1), 277–284 (2010).
[Crossref] [PubMed]

2009 (2)

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

2000 (1)

1998 (1)

N. Dognitz and G. Wagnieres, “Determination of tissue optical properties by steady-state spatial frequency-domain reflectometry,” Lasers Med. Sci. 13, 55–65 (1998).
[Crossref]

1997 (1)

1994 (1)

W. Zhou and X. Su, “A direct mapping algorithm for phase-measuring profilometry,” J. Mod. Opt. 41(1), 89–94 (1994).
[Crossref]

1992 (1)

T. J. Farrell, M. S. Patterson, and B. Wilson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19(4), 879–888 (1992).
[Crossref] [PubMed]

1984 (1)

1983 (1)

1978 (1)

Abran, M.

S. Bélanger, M. Abran, X. Intes, C. Casanova, and F. Lesage, “Real-time diffuse optical tomography based on structured illumination,” J. Biomed. Opt. 15(1), 016006 (2010).
[Crossref] [PubMed]

Arridge, S.

Arts, H. J.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Ashitate, Y.

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Ayers, F. R.

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Bart, J.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Barth, R. J.

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res. 15(4), R61 (2013).
[Crossref] [PubMed]

Bassi, A.

Bélanger, S.

S. Bélanger, M. Abran, X. Intes, C. Casanova, and F. Lesage, “Real-time diffuse optical tomography based on structured illumination,” J. Biomed. Opt. 15(1), 016006 (2010).
[Crossref] [PubMed]

Berger, A. J.

Bevilacqua, F.

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

F. Bevilacqua, A. J. Berger, A. E. Cerussi, D. Jakubowski, and B. J. Tromberg, “Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods,” Appl. Opt. 39(34), 6498–6507 (2000).
[Crossref] [PubMed]

Burmeister, D. M.

Butler, J. A.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Casanova, C.

S. Bélanger, M. Abran, X. Intes, C. Casanova, and F. Lesage, “Real-time diffuse optical tomography based on structured illumination,” J. Biomed. Opt. 15(1), 016006 (2010).
[Crossref] [PubMed]

Cerussi, A.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Cerussi, A. E.

S. Kukreti, A. E. Cerussi, W. Tanamai, D. Hsiang, B. J. Tromberg, and E. Gratton, “Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy,” Radiology 254(1), 277–284 (2010).
[Crossref] [PubMed]

F. Bevilacqua, A. J. Berger, A. E. Cerussi, D. Jakubowski, and B. J. Tromberg, “Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods,” Appl. Opt. 39(34), 6498–6507 (2000).
[Crossref] [PubMed]

Chen, W. P.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Choi, B.

Choi, H. S.

S. Gioux, H. S. Choi, and J. V. Frangioni, “Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation,” Mol. Imaging 9(5), 237–255 (2010).
[PubMed]

Christy, R. J.

Crane, L. M.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Cuccia, D.

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

Cuccia, D. J.

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res. 15(4), R61 (2013).
[Crossref] [PubMed]

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

D’Andrea, C.

de Jong, J. S.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Dognitz, N.

N. Dognitz and G. Wagnieres, “Determination of tissue optical properties by steady-state spatial frequency-domain reflectometry,” Lasers Med. Sci. 13, 55–65 (1998).
[Crossref]

Ducros, N.

Durkin, A.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Durkin, A. J.

A. Ponticorvo, D. M. Burmeister, B. Yang, B. Choi, R. J. Christy, and A. J. Durkin, “Quantitative assessment of graded burn wounds in a porcine model using spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI),” Biomed. Opt. Express 5(10), 3467–3481 (2014).
[Crossref] [PubMed]

K. P. Nadeau, A. J. Durkin, and B. J. Tromberg, “Advanced demodulation technique for the extraction of tissue optical properties and structural orientation contrast in the spatial frequency domain,” J. Biomed. Opt. 19(5), 056013 (2014).
[Crossref] [PubMed]

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Durr, N. J.

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Erickson, T. A.

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

Evans, G. R.

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Farrell, T. J.

T. J. Farrell, M. S. Patterson, and B. Wilson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19(4), 879–888 (1992).
[Crossref] [PubMed]

Frangioni, J. V.

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

S. Gioux, H. S. Choi, and J. V. Frangioni, “Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation,” Mol. Imaging 9(5), 237–255 (2010).
[PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

Ghassemi, P.

T. E. Travis, P. Ghassemi, J. C. Ramella-Roman, N. J. Prindeze, D. W. Paul, L. T. Moffatt, M. H. Jordan, and J. W. Shupp, “A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar,” J. Burn Care Res. 36(1), 77–86 (2015).
[Crossref] [PubMed]

Gioux, S.

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

J. Vervandier and S. Gioux, “Single snapshot imaging of optical properties,” Biomed. Opt. Express 4(12), 2938–2944 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

S. Gioux, H. S. Choi, and J. V. Frangioni, “Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation,” Mol. Imaging 9(5), 237–255 (2010).
[PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

Gratton, E.

S. Kukreti, A. E. Cerussi, W. Tanamai, D. Hsiang, B. J. Tromberg, and E. Gratton, “Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy,” Radiology 254(1), 277–284 (2010).
[Crossref] [PubMed]

Halioua, M.

Harlaar, N. J.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Hsiang, D.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

S. Kukreti, A. E. Cerussi, W. Tanamai, D. Hsiang, B. J. Tromberg, and E. Gratton, “Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy,” Radiology 254(1), 277–284 (2010).
[Crossref] [PubMed]

Huihui, J.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Indebetouw, G.

Intes, X.

S. Bélanger, M. Abran, X. Intes, C. Casanova, and F. Lesage, “Real-time diffuse optical tomography based on structured illumination,” J. Biomed. Opt. 15(1), 016006 (2010).
[Crossref] [PubMed]

Jakubowski, D.

Jordan, M. H.

T. E. Travis, P. Ghassemi, J. C. Ramella-Roman, N. J. Prindeze, D. W. Paul, L. T. Moffatt, M. H. Jordan, and J. W. Shupp, “A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar,” J. Burn Care Res. 36(1), 77–86 (2015).
[Crossref] [PubMed]

Juskaitis, R.

Kelder, W.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Kelly, E.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Keymel, K.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Krishnaswamy, V.

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res. 15(4), R61 (2013).
[Crossref] [PubMed]

Kukreti, S.

S. Kukreti, A. E. Cerussi, W. Tanamai, D. Hsiang, B. J. Tromberg, and E. Gratton, “Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy,” Radiology 254(1), 277–284 (2010).
[Crossref] [PubMed]

Laughney, A. M.

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res. 15(4), R61 (2013).
[Crossref] [PubMed]

Lee, B. T.

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Lesage, F.

S. Bélanger, M. Abran, X. Intes, C. Casanova, and F. Lesage, “Real-time diffuse optical tomography based on structured illumination,” J. Biomed. Opt. 15(1), 016006 (2010).
[Crossref] [PubMed]

Lin, S. J.

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Liu, H. C.

Low, P. S.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Mazhar, A.

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

McLaren, C.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Mehta, R.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Moffatt, L. T.

T. E. Travis, P. Ghassemi, J. C. Ramella-Roman, N. J. Prindeze, D. W. Paul, L. T. Moffatt, M. H. Jordan, and J. W. Shupp, “A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar,” J. Burn Care Res. 36(1), 77–86 (2015).
[Crossref] [PubMed]

Moffitt, L. A.

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Morgan, J.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Muffoletto, D.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Mutoh, K.

Nadeau, K. P.

K. P. Nadeau, A. J. Durkin, and B. J. Tromberg, “Advanced demodulation technique for the extraction of tissue optical properties and structural orientation contrast in the spatial frequency domain,” J. Biomed. Opt. 19(5), 056013 (2014).
[Crossref] [PubMed]

Neil, M. A.

Nguyen, J. T.

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

Ntziachristos, V.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Oketokoun, R.

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Paquette, A.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Patel, S.

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Patterson, M. S.

T. J. Farrell, M. S. Patterson, and B. Wilson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19(4), 879–888 (1992).
[Crossref] [PubMed]

Paul, D. W.

T. E. Travis, P. Ghassemi, J. C. Ramella-Roman, N. J. Prindeze, D. W. Paul, L. T. Moffatt, M. H. Jordan, and J. W. Shupp, “A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar,” J. Burn Care Res. 36(1), 77–86 (2015).
[Crossref] [PubMed]

Paulsen, K. D.

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res. 15(4), R61 (2013).
[Crossref] [PubMed]

Pleijhuis, R. G.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Pogue, B. W.

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res. 15(4), R61 (2013).
[Crossref] [PubMed]

Ponticorvo, A.

Prindeze, N. J.

T. E. Travis, P. Ghassemi, J. C. Ramella-Roman, N. J. Prindeze, D. W. Paul, L. T. Moffatt, M. H. Jordan, and J. W. Shupp, “A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar,” J. Burn Care Res. 36(1), 77–86 (2015).
[Crossref] [PubMed]

Ramella-Roman, J. C.

T. E. Travis, P. Ghassemi, J. C. Ramella-Roman, N. J. Prindeze, D. W. Paul, L. T. Moffatt, M. H. Jordan, and J. W. Shupp, “A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar,” J. Burn Care Res. 36(1), 77–86 (2015).
[Crossref] [PubMed]

Rizzo, E. J.

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res. 15(4), R61 (2013).
[Crossref] [PubMed]

Roblyer, D.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Rohrbach, D. J.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Saager, R.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Saager, R. B.

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Sarantopoulos, A.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Scholz, T.

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Schwab, M. C.

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res. 15(4), R61 (2013).
[Crossref] [PubMed]

Shupp, J. W.

T. E. Travis, P. Ghassemi, J. C. Ramella-Roman, N. J. Prindeze, D. W. Paul, L. T. Moffatt, M. H. Jordan, and J. W. Shupp, “A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar,” J. Burn Care Res. 36(1), 77–86 (2015).
[Crossref] [PubMed]

Srinivasan, V.

Stockdale, A.

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Su, X.

W. Zhou and X. Su, “A direct mapping algorithm for phase-measuring profilometry,” J. Mod. Opt. 41(1), 89–94 (1994).
[Crossref]

Sunar, U.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Takeda, M.

Tanamai, W.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

S. Kukreti, A. E. Cerussi, W. Tanamai, D. Hsiang, B. J. Tromberg, and E. Gratton, “Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy,” Radiology 254(1), 277–284 (2010).
[Crossref] [PubMed]

Themelis, G.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Tobias, A. M.

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Travis, T. E.

T. E. Travis, P. Ghassemi, J. C. Ramella-Roman, N. J. Prindeze, D. W. Paul, L. T. Moffatt, M. H. Jordan, and J. W. Shupp, “A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar,” J. Burn Care Res. 36(1), 77–86 (2015).
[Crossref] [PubMed]

Tromberg, B.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Tromberg, B. J.

K. P. Nadeau, A. J. Durkin, and B. J. Tromberg, “Advanced demodulation technique for the extraction of tissue optical properties and structural orientation contrast in the spatial frequency domain,” J. Biomed. Opt. 19(5), 056013 (2014).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res. 15(4), R61 (2013).
[Crossref] [PubMed]

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

S. Kukreti, A. E. Cerussi, W. Tanamai, D. Hsiang, B. J. Tromberg, and E. Gratton, “Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy,” Radiology 254(1), 277–284 (2010).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

F. Bevilacqua, A. J. Berger, A. E. Cerussi, D. Jakubowski, and B. J. Tromberg, “Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods,” Appl. Opt. 39(34), 6498–6507 (2000).
[Crossref] [PubMed]

Tunnell, J. W.

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

Ueda, S.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Valentini, G.

van Dam, G. M.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

van der Zee, A. G.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Vervandier, J.

Vetter, T. S.

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Wagnieres, G.

N. Dognitz and G. Wagnieres, “Determination of tissue optical properties by steady-state spatial frequency-domain reflectometry,” Lasers Med. Sci. 13, 55–65 (1998).
[Crossref]

Weinmann, M.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Wells, W. A.

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res. 15(4), R61 (2013).
[Crossref] [PubMed]

Wilson, B.

T. J. Farrell, M. S. Patterson, and B. Wilson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19(4), 879–888 (1992).
[Crossref] [PubMed]

Wilson, T.

Yafi, A.

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Yang, B.

Zeitouni, N.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Zhou, W.

W. Zhou and X. Su, “A direct mapping algorithm for phase-measuring profilometry,” J. Mod. Opt. 41(1), 89–94 (1994).
[Crossref]

Acad. Radiol. (1)

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Ann. Plast. Surg. (1)

J. T. Nguyen, S. J. Lin, A. M. Tobias, S. Gioux, A. Mazhar, D. J. Cuccia, Y. Ashitate, A. Stockdale, R. Oketokoun, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, J. V. Frangioni, and B. T. Lee, “A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery,” Ann. Plast. Surg. 71(3), 308–315 (2013).
[Crossref] [PubMed]

Appl. Opt. (4)

Biomed. Opt. Express (3)

Breast Cancer Res. (1)

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res. 15(4), R61 (2013).
[Crossref] [PubMed]

J. Biomed. Opt. (6)

T. A. Erickson, A. Mazhar, D. Cuccia, A. J. Durkin, and J. W. Tunnell, “Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime,” J. Biomed. Opt. 15(3), 036013 (2010).
[Crossref] [PubMed]

S. Bélanger, M. Abran, X. Intes, C. Casanova, and F. Lesage, “Real-time diffuse optical tomography based on structured illumination,” J. Biomed. Opt. 15(1), 016006 (2010).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

K. P. Nadeau, A. J. Durkin, and B. J. Tromberg, “Advanced demodulation technique for the extraction of tissue optical properties and structural orientation contrast in the spatial frequency domain,” J. Biomed. Opt. 19(5), 056013 (2014).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

J. Burn Care Res. (1)

T. E. Travis, P. Ghassemi, J. C. Ramella-Roman, N. J. Prindeze, D. W. Paul, L. T. Moffatt, M. H. Jordan, and J. W. Shupp, “A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar,” J. Burn Care Res. 36(1), 77–86 (2015).
[Crossref] [PubMed]

J. Mod. Opt. (1)

W. Zhou and X. Su, “A direct mapping algorithm for phase-measuring profilometry,” J. Mod. Opt. 41(1), 89–94 (1994).
[Crossref]

Lasers Med. Sci. (1)

N. Dognitz and G. Wagnieres, “Determination of tissue optical properties by steady-state spatial frequency-domain reflectometry,” Lasers Med. Sci. 13, 55–65 (1998).
[Crossref]

Med. Phys. (1)

T. J. Farrell, M. S. Patterson, and B. Wilson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19(4), 879–888 (1992).
[Crossref] [PubMed]

Mol. Imaging (1)

S. Gioux, H. S. Choi, and J. V. Frangioni, “Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation,” Mol. Imaging 9(5), 237–255 (2010).
[PubMed]

Nat. Med. (1)

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Opt. Lett. (1)

Plast. Reconstr. Surg. (1)

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Radiology (1)

S. Kukreti, A. E. Cerussi, W. Tanamai, D. Hsiang, B. J. Tromberg, and E. Gratton, “Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy,” Radiology 254(1), 277–284 (2010).
[Crossref] [PubMed]

Other (1)

F. Ayers, A. Grant, D. Kuo, D. J. Cuccia, and A. J. Durkin, “Fabrication and characterization of silicone-based tissue phantoms with tunable optical properties in the visible and near infrared domain,” in Proc. SPIE, 2008), 6870E.

Supplementary Material (2)

NameDescription
» Visualization 1: AVI (7773 KB)      Hemispheric phantom movie
» Visualization 2: AVI (16581 KB)      In-vivo hand movie

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Figures (6)

Fig. 1
Fig. 1

3-D Single Snapshot of Optical Properties. A dual sinusoidal wave is projected, one wave being sensitive to the specimen’s optical properties and the other to the specimen’s profile. AC & DC components as well as phase are extracted (not shown here) leading to profile, absorption and reduced scattering.

Fig. 2
Fig. 2

Data processing for 3-D Single Snapshot of Optical Properties. The acquired image (A) is expanded by mirroring (B) and a 2D Fourier transform performed (C). Filters (D, E and F) are then used to isolate the DC component (G), the AC component (H) and the phase (I), respectively.

Fig. 3
Fig. 3

Flat homogeneous phantom measurements. 3D-SFDI and 3D-SSOP methods were used to acquire and process a set of homogeneous phantoms at different heights (A and B, respectively). Notice the good agreement in heights (C), and in profile-corrected values for absorption (D) and reduced scattering (E).

Fig. 4
Fig. 4

Hemispheric phantom measurements. 3D-SFDI and 3D-SSOP methods were used to acquire and process a hemispheric homogeneous phantom. Notice the good agreement in heights, as well as in profile corrected values for absorption and reduced scattering.

Fig. 5
Fig. 5

Frame from the hemispheric phantom movie. A movie of a homogeneous hemispheric phantom was acquired with the 3D-SSOP method. Raw data (top, left), 3D profile (top, right), profile-corrected absorption (bottom, left) and reduced scattering (bottom, right) are shown. See Visualization 1.

Fig. 6
Fig. 6

Frame from the in-vivo hand movie. A movie of a hand was acquired with the 3D-SSOP method. Raw data (top, left), 3D profile (top, right), profile-corrected absorption (bottom, left) and reduced scattering (bottom, right) are shown. See Visualization 2.

Equations (5)

Equations on this page are rendered with MathJax. Learn more.

I i (x, f x )=M(x, f x )cos( f x x+ ϕ i )+ I DC (x)
M(x, f x )= 2{ [ I 1 (x, f x ) I 2 (x, f x ) ] 2 + [ I 2 (x, f x ) I 3 (x, f x ) ] 2 + [ I 3 (x, f x ) I 1 (x, f x ) ] 2 } 3
M(x, f x )= I 0 MT F sys (x, f x )Rd(x, f x )
Rd(x, f x )= M(x, f x ) M ref (x, f x ) R d ref (x, f x )
I(x,y, f x , f y )= 1 2 + 1 4 [ cos( f x x+ ϕ x )+cos( f y y+ ϕ y ) ]

Metrics