Abstract

In this manuscript, the initial feasibility of a catheter based phase stabilized swept source optical coherence tomography (OCT) system was studied for characterization of the strain inside different human ovarian tissue groups. The ovarian tissue samples were periodically compressed with 500 Hz square wave signal along the axial direction between the surface of an unfocused transducer and a glass cover slide. The displacement and corresponding strain were calculated during loading from different locations for each tissue sample. A total of 27 ex vivo ovaries from 16 patients were investigated. Statistically significant difference (p < 0.001) was observed between the average displacement and strain of the normal and malignant tissue groups. A sensitivity of 93.2% and a specificity of 83% were achieved using 25 microstrain (με) as the threshold. The collagen content of the tissues was quantified from the Sirius Red stained histological sections. The average collagen area fraction (CAF) obtained from the tissue groups were found to have a strong negative correlation (R = −0.75, p < 0.0001) with the amount of strain inside the tissue. This indicates much softer and degenerated tissue structure for the malignant ovaries as compared to the dense, collagen rich structure of the normal ovarian tissue. The initial results indicate that the swept source OCT system can be useful for estimating the elasticity of the human ovarian tissue.

© 2015 Optical Society of America

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2015 (3)

2013 (2)

G. Guan, C. Li, Y. Ling, Y. Yang, J. B. Vorstius, R. P. Keatch, R. K. Wang, and Z. Huang, “Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method,” J. Biomed. Opt. 18(11), 111417 (2013).
[Crossref] [PubMed]

K. M. Kennedy, R. A. McLaughlin, B. F. Kennedy, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues,” J. Biomed. Opt. 18(12), 121510 (2013).
[Crossref] [PubMed]

2012 (4)

M. Razani, A. Mariampillai, C. Sun, T. W. H. Luk, V. X. D. Yang, and M. C. Kolios, “Feasibility of optical coherence elastography measurements of shear wave propagation in homogeneous tissue equivalent phantoms,” Biomed. Opt. Express 3(5), 972–980 (2012).
[Crossref] [PubMed]

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

R. K. Manapuram, S. R. Aglyamov, F. M. Monediado, M. Mashiatulla, J. Li, S. Y. Emelianov, and K. V. Larin, “In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography,” J. Biomed. Opt. 17(10), 100501 (2012).
[Crossref] [PubMed]

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

2011 (1)

O. Dzatic-Smiljkovic, M. Vasiljevic, M. Djukic, R. Vugdelic, and J. Vugdelic, “Frequency of ovarian endometriosis in epithelial ovarian cancer patients,” Clin. Exp. Obstet. Gynecol. 38(4), 394–398 (2011).
[PubMed]

2007 (2)

E. Gheorghe, V. Tomuţa, T. Mehedinţi, M. Hîncu, and V. Broască, “Comparative microscopic study of the ovarian blood vessels,” Rom. J. Morphol. Embryol. 48(2), 151–154 (2007).
[PubMed]

R. K. Wang, S. Kirkpatrick, and M. Hinds, “Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time,” Appl. Phys. Lett. 90(16), 164105 (2007).
[Crossref]

2006 (4)

R. K. Wang, Z. H. Ma, and S. J. Kirkpatrick, “Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue,” Appl. Phys. Lett. 89(14), 144103 (2006).
[Crossref]

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[Crossref] [PubMed]

A. K. Lind, B. Weijdegård, P. Dahm-Kähler, J. Mölne, K. Sundfeldt, and M. Brännström, “Collagens in the human ovary and their changes in the perifollicular stroma during ovulation,” Acta Obstet. Gynecol. Scand. 85(12), 1476–1484 (2006).
[Crossref] [PubMed]

S. J. Kirkpatrick, R. K. Wang, and D. D. Duncan, “OCT-based elastography for large and small deformations,” Opt. Express 14(24), 11585–11597 (2006).
[Crossref] [PubMed]

2002 (1)

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

1998 (1)

1995 (1)

W. Malkusch, B. Rehn, and J. Bruch, “Advantages of Sirius Red staining for quantitative morphometric collagen measurements in lungs,” Exp. Lung Res. 21(1), 67–77 (1995).
[Crossref] [PubMed]

Aglyamov, S. R.

R. K. Manapuram, S. R. Aglyamov, F. M. Monediado, M. Mashiatulla, J. Li, S. Y. Emelianov, and K. V. Larin, “In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography,” J. Biomed. Opt. 17(10), 100501 (2012).
[Crossref] [PubMed]

Brännström, M.

A. K. Lind, B. Weijdegård, P. Dahm-Kähler, J. Mölne, K. Sundfeldt, and M. Brännström, “Collagens in the human ovary and their changes in the perifollicular stroma during ovulation,” Acta Obstet. Gynecol. Scand. 85(12), 1476–1484 (2006).
[Crossref] [PubMed]

Brewer, M.

T. Wang, M. Brewer, and Q. Zhu, “An overview of optical coherence tomography for ovarian tissue imaging and characterization,” Nanomed. Nanobiotechnol. 7(1), 1–16 (2015).
[Crossref] [PubMed]

Broasca, V.

E. Gheorghe, V. Tomuţa, T. Mehedinţi, M. Hîncu, and V. Broască, “Comparative microscopic study of the ovarian blood vessels,” Rom. J. Morphol. Embryol. 48(2), 151–154 (2007).
[PubMed]

Bruch, J.

W. Malkusch, B. Rehn, and J. Bruch, “Advantages of Sirius Red staining for quantitative morphometric collagen measurements in lungs,” Exp. Lung Res. 21(1), 67–77 (1995).
[Crossref] [PubMed]

Chen, R.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

Chen, Z.

Chou, L.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

Dahm-Kähler, P.

A. K. Lind, B. Weijdegård, P. Dahm-Kähler, J. Mölne, K. Sundfeldt, and M. Brännström, “Collagens in the human ovary and their changes in the perifollicular stroma during ovulation,” Acta Obstet. Gynecol. Scand. 85(12), 1476–1484 (2006).
[Crossref] [PubMed]

Daly, M. B.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

de Andrade, M.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[Crossref] [PubMed]

Djukic, M.

O. Dzatic-Smiljkovic, M. Vasiljevic, M. Djukic, R. Vugdelic, and J. Vugdelic, “Frequency of ovarian endometriosis in epithelial ovarian cancer patients,” Clin. Exp. Obstet. Gynecol. 38(4), 394–398 (2011).
[PubMed]

Du, Y.

Duncan, D. D.

Dzatic-Smiljkovic, O.

O. Dzatic-Smiljkovic, M. Vasiljevic, M. Djukic, R. Vugdelic, and J. Vugdelic, “Frequency of ovarian endometriosis in epithelial ovarian cancer patients,” Clin. Exp. Obstet. Gynecol. 38(4), 394–398 (2011).
[PubMed]

Emelianov, S. Y.

R. K. Manapuram, S. R. Aglyamov, F. M. Monediado, M. Mashiatulla, J. Li, S. Y. Emelianov, and K. V. Larin, “In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography,” J. Biomed. Opt. 17(10), 100501 (2012).
[Crossref] [PubMed]

Evans, G.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

Fujimoto, J. G.

Gao, S. S.

Garber, J. E.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

Gheorghe, E.

E. Gheorghe, V. Tomuţa, T. Mehedinţi, M. Hîncu, and V. Broască, “Comparative microscopic study of the ovarian blood vessels,” Rom. J. Morphol. Embryol. 48(2), 151–154 (2007).
[PubMed]

Grossardt, B. R.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[Crossref] [PubMed]

Guan, G.

G. Guan, C. Li, Y. Ling, Y. Yang, J. B. Vorstius, R. P. Keatch, R. K. Wang, and Z. Huang, “Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method,” J. Biomed. Opt. 18(11), 111417 (2013).
[Crossref] [PubMed]

Hîncu, M.

E. Gheorghe, V. Tomuţa, T. Mehedinţi, M. Hîncu, and V. Broască, “Comparative microscopic study of the ovarian blood vessels,” Rom. J. Morphol. Embryol. 48(2), 151–154 (2007).
[PubMed]

Hinds, M.

R. K. Wang, S. Kirkpatrick, and M. Hinds, “Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time,” Appl. Phys. Lett. 90(16), 164105 (2007).
[Crossref]

Huang, D.

Huang, S.

Huang, Z.

G. Guan, C. Li, Y. Ling, Y. Yang, J. B. Vorstius, R. P. Keatch, R. K. Wang, and Z. Huang, “Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method,” J. Biomed. Opt. 18(11), 111417 (2013).
[Crossref] [PubMed]

Isaacs, C.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

Keatch, R. P.

G. Guan, C. Li, Y. Ling, Y. Yang, J. B. Vorstius, R. P. Keatch, R. K. Wang, and Z. Huang, “Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method,” J. Biomed. Opt. 18(11), 111417 (2013).
[Crossref] [PubMed]

Kennedy, B. F.

K. M. Kennedy, R. A. McLaughlin, B. F. Kennedy, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues,” J. Biomed. Opt. 18(12), 121510 (2013).
[Crossref] [PubMed]

Kennedy, K. M.

K. M. Kennedy, R. A. McLaughlin, B. F. Kennedy, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues,” J. Biomed. Opt. 18(12), 121510 (2013).
[Crossref] [PubMed]

Kim, B.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Kirkpatrick, S.

R. K. Wang, S. Kirkpatrick, and M. Hinds, “Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time,” Appl. Phys. Lett. 90(16), 164105 (2007).
[Crossref]

Kirkpatrick, S. J.

R. K. Wang, Z. H. Ma, and S. J. Kirkpatrick, “Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue,” Appl. Phys. Lett. 89(14), 144103 (2006).
[Crossref]

S. J. Kirkpatrick, R. K. Wang, and D. D. Duncan, “OCT-based elastography for large and small deformations,” Opt. Express 14(24), 11585–11597 (2006).
[Crossref] [PubMed]

Kolios, M. C.

Larin, K. V.

R. K. Manapuram, S. R. Aglyamov, F. M. Monediado, M. Mashiatulla, J. Li, S. Y. Emelianov, and K. V. Larin, “In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography,” J. Biomed. Opt. 17(10), 100501 (2012).
[Crossref] [PubMed]

Latham, B.

K. M. Kennedy, R. A. McLaughlin, B. F. Kennedy, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues,” J. Biomed. Opt. 18(12), 121510 (2013).
[Crossref] [PubMed]

Lee, B.

Li, C.

G. Guan, C. Li, Y. Ling, Y. Yang, J. B. Vorstius, R. P. Keatch, R. K. Wang, and Z. Huang, “Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method,” J. Biomed. Opt. 18(11), 111417 (2013).
[Crossref] [PubMed]

Li, J.

R. K. Manapuram, S. R. Aglyamov, F. M. Monediado, M. Mashiatulla, J. Li, S. Y. Emelianov, and K. V. Larin, “In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography,” J. Biomed. Opt. 17(10), 100501 (2012).
[Crossref] [PubMed]

Li, R.

Lind, A. K.

A. K. Lind, B. Weijdegård, P. Dahm-Kähler, J. Mölne, K. Sundfeldt, and M. Brännström, “Collagens in the human ovary and their changes in the perifollicular stroma during ovulation,” Acta Obstet. Gynecol. Scand. 85(12), 1476–1484 (2006).
[Crossref] [PubMed]

Ling, Y.

G. Guan, C. Li, Y. Ling, Y. Yang, J. B. Vorstius, R. P. Keatch, R. K. Wang, and Z. Huang, “Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method,” J. Biomed. Opt. 18(11), 111417 (2013).
[Crossref] [PubMed]

Liu, G.

Lu, C. D.

Luk, T. W. H.

Lynch, H. T.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

Ma, T.

Ma, Z. H.

R. K. Wang, Z. H. Ma, and S. J. Kirkpatrick, “Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue,” Appl. Phys. Lett. 89(14), 144103 (2006).
[Crossref]

Malkasian, G. D.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[Crossref] [PubMed]

Malkusch, W.

W. Malkusch, B. Rehn, and J. Bruch, “Advantages of Sirius Red staining for quantitative morphometric collagen measurements in lungs,” Exp. Lung Res. 21(1), 67–77 (1995).
[Crossref] [PubMed]

Manapuram, R. K.

R. K. Manapuram, S. R. Aglyamov, F. M. Monediado, M. Mashiatulla, J. Li, S. Y. Emelianov, and K. V. Larin, “In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography,” J. Biomed. Opt. 17(10), 100501 (2012).
[Crossref] [PubMed]

Mariampillai, A.

Mashiatulla, M.

R. K. Manapuram, S. R. Aglyamov, F. M. Monediado, M. Mashiatulla, J. Li, S. Y. Emelianov, and K. V. Larin, “In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography,” J. Biomed. Opt. 17(10), 100501 (2012).
[Crossref] [PubMed]

Matloff, E.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

McDonald, J.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

McLaughlin, R. A.

K. M. Kennedy, R. A. McLaughlin, B. F. Kennedy, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues,” J. Biomed. Opt. 18(12), 121510 (2013).
[Crossref] [PubMed]

Mehedinti, T.

E. Gheorghe, V. Tomuţa, T. Mehedinţi, M. Hîncu, and V. Broască, “Comparative microscopic study of the ovarian blood vessels,” Rom. J. Morphol. Embryol. 48(2), 151–154 (2007).
[PubMed]

Melton, L. J.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[Crossref] [PubMed]

Mezencev, R.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Mölne, J.

A. K. Lind, B. Weijdegård, P. Dahm-Kähler, J. Mölne, K. Sundfeldt, and M. Brännström, “Collagens in the human ovary and their changes in the perifollicular stroma during ovulation,” Acta Obstet. Gynecol. Scand. 85(12), 1476–1484 (2006).
[Crossref] [PubMed]

Monediado, F. M.

R. K. Manapuram, S. R. Aglyamov, F. M. Monediado, M. Mashiatulla, J. Li, S. Y. Emelianov, and K. V. Larin, “In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography,” J. Biomed. Opt. 17(10), 100501 (2012).
[Crossref] [PubMed]

Narod, S. A.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

Neuhausen, S. L.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

Olopade, O. I.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

Pechauer, A. D.

Qi, W.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

Qu, Y.

Razani, M.

Rebbeck, T. R.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

Rehn, B.

W. Malkusch, B. Rehn, and J. Bruch, “Advantages of Sirius Red staining for quantitative morphometric collagen measurements in lungs,” Exp. Lung Res. 21(1), 67–77 (1995).
[Crossref] [PubMed]

Rocca, W. A.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[Crossref] [PubMed]

Sampson, D. D.

K. M. Kennedy, R. A. McLaughlin, B. F. Kennedy, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues,” J. Biomed. Opt. 18(12), 121510 (2013).
[Crossref] [PubMed]

Saunders, C. M.

K. M. Kennedy, R. A. McLaughlin, B. F. Kennedy, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues,” J. Biomed. Opt. 18(12), 121510 (2013).
[Crossref] [PubMed]

Schmitt, J.

Shung, K. K.

Sulchek, T.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Sun, C.

Sundfeldt, K.

A. K. Lind, B. Weijdegård, P. Dahm-Kähler, J. Mölne, K. Sundfeldt, and M. Brännström, “Collagens in the human ovary and their changes in the perifollicular stroma during ovulation,” Acta Obstet. Gynecol. Scand. 85(12), 1476–1484 (2006).
[Crossref] [PubMed]

Tan, O.

Tien, A.

K. M. Kennedy, R. A. McLaughlin, B. F. Kennedy, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues,” J. Biomed. Opt. 18(12), 121510 (2013).
[Crossref] [PubMed]

Tomuta, V.

E. Gheorghe, V. Tomuţa, T. Mehedinţi, M. Hîncu, and V. Broască, “Comparative microscopic study of the ovarian blood vessels,” Rom. J. Morphol. Embryol. 48(2), 151–154 (2007).
[PubMed]

Van’t Veer, L.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

Vasiljevic, M.

O. Dzatic-Smiljkovic, M. Vasiljevic, M. Djukic, R. Vugdelic, and J. Vugdelic, “Frequency of ovarian endometriosis in epithelial ovarian cancer patients,” Clin. Exp. Obstet. Gynecol. 38(4), 394–398 (2011).
[PubMed]

Vorstius, J. B.

G. Guan, C. Li, Y. Ling, Y. Yang, J. B. Vorstius, R. P. Keatch, R. K. Wang, and Z. Huang, “Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method,” J. Biomed. Opt. 18(11), 111417 (2013).
[Crossref] [PubMed]

Vugdelic, J.

O. Dzatic-Smiljkovic, M. Vasiljevic, M. Djukic, R. Vugdelic, and J. Vugdelic, “Frequency of ovarian endometriosis in epithelial ovarian cancer patients,” Clin. Exp. Obstet. Gynecol. 38(4), 394–398 (2011).
[PubMed]

Vugdelic, R.

O. Dzatic-Smiljkovic, M. Vasiljevic, M. Djukic, R. Vugdelic, and J. Vugdelic, “Frequency of ovarian endometriosis in epithelial ovarian cancer patients,” Clin. Exp. Obstet. Gynecol. 38(4), 394–398 (2011).
[PubMed]

Wang, L.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Wang, R. K.

G. Guan, C. Li, Y. Ling, Y. Yang, J. B. Vorstius, R. P. Keatch, R. K. Wang, and Z. Huang, “Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method,” J. Biomed. Opt. 18(11), 111417 (2013).
[Crossref] [PubMed]

R. K. Wang, S. Kirkpatrick, and M. Hinds, “Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time,” Appl. Phys. Lett. 90(16), 164105 (2007).
[Crossref]

R. K. Wang, Z. H. Ma, and S. J. Kirkpatrick, “Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue,” Appl. Phys. Lett. 89(14), 144103 (2006).
[Crossref]

S. J. Kirkpatrick, R. K. Wang, and D. D. Duncan, “OCT-based elastography for large and small deformations,” Opt. Express 14(24), 11585–11597 (2006).
[Crossref] [PubMed]

Wang, T.

T. Wang, M. Brewer, and Q. Zhu, “An overview of optical coherence tomography for ovarian tissue imaging and characterization,” Nanomed. Nanobiotechnol. 7(1), 1–16 (2015).
[Crossref] [PubMed]

Weber, B. L.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

Weijdegård, B.

A. K. Lind, B. Weijdegård, P. Dahm-Kähler, J. Mölne, K. Sundfeldt, and M. Brännström, “Collagens in the human ovary and their changes in the perifollicular stroma during ovulation,” Acta Obstet. Gynecol. Scand. 85(12), 1476–1484 (2006).
[Crossref] [PubMed]

Xu, W.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Yang, V. X. D.

Yang, Y.

G. Guan, C. Li, Y. Ling, Y. Yang, J. B. Vorstius, R. P. Keatch, R. K. Wang, and Z. Huang, “Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method,” J. Biomed. Opt. 18(11), 111417 (2013).
[Crossref] [PubMed]

Zhang, J.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

Zhou, Q.

Zhu, J.

Zhu, Q.

T. Wang, M. Brewer, and Q. Zhu, “An overview of optical coherence tomography for ovarian tissue imaging and characterization,” Nanomed. Nanobiotechnol. 7(1), 1–16 (2015).
[Crossref] [PubMed]

Acta Obstet. Gynecol. Scand. (1)

A. K. Lind, B. Weijdegård, P. Dahm-Kähler, J. Mölne, K. Sundfeldt, and M. Brännström, “Collagens in the human ovary and their changes in the perifollicular stroma during ovulation,” Acta Obstet. Gynecol. Scand. 85(12), 1476–1484 (2006).
[Crossref] [PubMed]

Appl. Phys. Lett. (2)

R. K. Wang, Z. H. Ma, and S. J. Kirkpatrick, “Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue,” Appl. Phys. Lett. 89(14), 144103 (2006).
[Crossref]

R. K. Wang, S. Kirkpatrick, and M. Hinds, “Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time,” Appl. Phys. Lett. 90(16), 164105 (2007).
[Crossref]

Biomed. Opt. Express (1)

Clin. Exp. Obstet. Gynecol. (1)

O. Dzatic-Smiljkovic, M. Vasiljevic, M. Djukic, R. Vugdelic, and J. Vugdelic, “Frequency of ovarian endometriosis in epithelial ovarian cancer patients,” Clin. Exp. Obstet. Gynecol. 38(4), 394–398 (2011).
[PubMed]

Exp. Lung Res. (1)

W. Malkusch, B. Rehn, and J. Bruch, “Advantages of Sirius Red staining for quantitative morphometric collagen measurements in lungs,” Exp. Lung Res. 21(1), 67–77 (1995).
[Crossref] [PubMed]

J. Biomed. Opt. (4)

R. K. Manapuram, S. R. Aglyamov, F. M. Monediado, M. Mashiatulla, J. Li, S. Y. Emelianov, and K. V. Larin, “In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography,” J. Biomed. Opt. 17(10), 100501 (2012).
[Crossref] [PubMed]

K. M. Kennedy, R. A. McLaughlin, B. F. Kennedy, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues,” J. Biomed. Opt. 18(12), 121510 (2013).
[Crossref] [PubMed]

G. Guan, C. Li, Y. Ling, Y. Yang, J. B. Vorstius, R. P. Keatch, R. K. Wang, and Z. Huang, “Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method,” J. Biomed. Opt. 18(11), 111417 (2013).
[Crossref] [PubMed]

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

Lancet Oncol. (1)

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006).
[Crossref] [PubMed]

N. Engl. J. Med. (1)

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, and B. L. Weber, “Prevention and observation of surgical end points study group prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002).

Nanomed. Nanobiotechnol. (1)

T. Wang, M. Brewer, and Q. Zhu, “An overview of optical coherence tomography for ovarian tissue imaging and characterization,” Nanomed. Nanobiotechnol. 7(1), 1–16 (2015).
[Crossref] [PubMed]

Opt. Express (3)

Opt. Lett. (1)

PLoS One (1)

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Rom. J. Morphol. Embryol. (1)

E. Gheorghe, V. Tomuţa, T. Mehedinţi, M. Hîncu, and V. Broască, “Comparative microscopic study of the ovarian blood vessels,” Rom. J. Morphol. Embryol. 48(2), 151–154 (2007).
[PubMed]

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Figures (5)

Fig. 1
Fig. 1 Swept source optical coherence elastography configuration.
Fig. 2
Fig. 2 Examples from normal [(a) - (d)] and malignant [(e) - (h)] ovarian tissue. (a) and (e) OCT B-scan images, the white dashed area representing the locations from which M-mode images were acquired, (b) and (f) M-mode images, (c) and (g) SR stains showing collagen distribution, (d) and (h) corresponding averaged displacement curves. Slopes of the least square fitted red dashed lines in (d) and (h) represent the average strain.
Fig. 3
Fig. 3 (a) Histograms of με obtained from normal, abnormal and malignant ovarian tissue groups, along with Gaussian distribution fits. (b) Statistics of normal, abnormal and malignant groups. (c) ROC curve of με.
Fig. 4
Fig. 4 (a) Histograms of CAF obtained from normal, abnormal and malignant ovarian tissue groups, along with Gaussian distribution fits. (b) Statistics of normal, abnormal and malignant groups. (c) ROC curve of CAF.
Fig. 5
Fig. 5 Negative correlation demonstrated between estimated strain and tissue collagen content. The black dashed lines show 95% prediction intervals.

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