Abstract

This study describes the potential of wavelength-modulated differential photothermal radiometry (WM-DPTR) for non-invasive in-vehicle alcohol detection which can be of great importance in reducing alcohol-impaired driving. Ethanol content in the range of concern, 0-100 blood alcohol concentration (BAC) in water phantoms and blood serum diffused in human skin in vitro were measured with high sensitivity. The results show that the WM-DPTR system can be optimized for alcohol detection with the combination of two sensitivity-tuning parameters, amplitude ratio R and phase shift ΔP. WM-DPTR has demonstrated the potential to be developed into a portable alcohol ignition interlock biosensor that could be fitted as a universal accessory in vehicles.

© 2014 Optical Society of America

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References

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  1. Traffic Safety Facts, National Highway Traffic Safety Administration, (2013).
  2. S. Perreault, “Impaired driving in Canada, 2011”, Statistics Canada—Catalogue no. 85–002-X, (2013).
  3. C. Willis, S. Lybrand, and N. Bellamy, “Alcohol ignition interlock programmes for reducing drink driving recidivism,” Cochrane Database Syst. Rev.18(4), CD004168 (2004).
    [PubMed]
  4. S. A. Ferguson, E. Traube, A. Zaouk, and R. Strassburger, “Driver alcohol detection system for safety (DADSS) – a non-regulatory approach in thedevelopment and deployment of vehicle safety technology to reduce alcohol-impaired driving”, in Proceedings of the 21st International Technical Conference on the Enhanced Safety of Vehicles, (Stuttgart, Germany, 2009), pp. 09–0464.
  5. S. A. Ferguson, A. Zaouk, N. Dalal, C. Strohl, E. Traube, and R. Strassburger, “Driver alcohol detection system for safety (DADSS) –phase 1 prototype testing and findings”, in Proceedings of the 22rd International Technical Conference on the Enhanced Safety of Vehicles, (Washington, D.C., US, 2011), pp. 11–0230.
  6. U. S. Department of Transportation National Highway Traffic Safety Administration, J. Pollard, E. Nadler, and M. Stearns, Review of Technology to Prevent Alcohol-Impaired Crashes (TOPIC), (Createspace Independent Pub., 2007)
  7. A. Mandelis and X. Guo, “Method of performing wavelength modulated differential laser photothermal radiometry with high sensitivity,” US Patent No. 08649835 Cl. 600–316, issued on Feb. 11, 2014.
  8. A. Mandelis and X. Guo, “Wavelength-modulated differential photothermal radiometry: theory and experimental applications to glucose detection in water,” Phys. Rev. E.84(4), 041917 (2011).
    [CrossRef] [PubMed]
  9. X. Guo, A. Mandelis, and B. Zinman, “Non-invasive glucose detection in human skin using wavelength modulated differential laser photothermal radiometry,” Biomed. Opt. Express3, 3012–3021 (2012).
    [CrossRef] [PubMed]
  10. X. Guo, A. Mandelis, and B. Zinman, “Applications of ultrasensitive wavelength-modulated differential photothermal radiometry to noninvasive glucose detection in blood serum,” J. Biophotonics6(11-12), 911–919 (2013).
    [CrossRef] [PubMed]
  11. M. Venugopal, K. E. Feuvrel, D. Mongin, S. Bambot, M. Faupel, A. Panangadan, A. Talukder, and R. Pidva, “Clinical evaluation of a novel interstitial fluid sensor system for remote continuous alcohol monitoring,” IEEE Sensors J.8(1), 71–80 (2008).
    [CrossRef]

2013

X. Guo, A. Mandelis, and B. Zinman, “Applications of ultrasensitive wavelength-modulated differential photothermal radiometry to noninvasive glucose detection in blood serum,” J. Biophotonics6(11-12), 911–919 (2013).
[CrossRef] [PubMed]

2012

2011

A. Mandelis and X. Guo, “Wavelength-modulated differential photothermal radiometry: theory and experimental applications to glucose detection in water,” Phys. Rev. E.84(4), 041917 (2011).
[CrossRef] [PubMed]

2008

M. Venugopal, K. E. Feuvrel, D. Mongin, S. Bambot, M. Faupel, A. Panangadan, A. Talukder, and R. Pidva, “Clinical evaluation of a novel interstitial fluid sensor system for remote continuous alcohol monitoring,” IEEE Sensors J.8(1), 71–80 (2008).
[CrossRef]

2004

C. Willis, S. Lybrand, and N. Bellamy, “Alcohol ignition interlock programmes for reducing drink driving recidivism,” Cochrane Database Syst. Rev.18(4), CD004168 (2004).
[PubMed]

Bambot, S.

M. Venugopal, K. E. Feuvrel, D. Mongin, S. Bambot, M. Faupel, A. Panangadan, A. Talukder, and R. Pidva, “Clinical evaluation of a novel interstitial fluid sensor system for remote continuous alcohol monitoring,” IEEE Sensors J.8(1), 71–80 (2008).
[CrossRef]

Bellamy, N.

C. Willis, S. Lybrand, and N. Bellamy, “Alcohol ignition interlock programmes for reducing drink driving recidivism,” Cochrane Database Syst. Rev.18(4), CD004168 (2004).
[PubMed]

Faupel, M.

M. Venugopal, K. E. Feuvrel, D. Mongin, S. Bambot, M. Faupel, A. Panangadan, A. Talukder, and R. Pidva, “Clinical evaluation of a novel interstitial fluid sensor system for remote continuous alcohol monitoring,” IEEE Sensors J.8(1), 71–80 (2008).
[CrossRef]

Feuvrel, K. E.

M. Venugopal, K. E. Feuvrel, D. Mongin, S. Bambot, M. Faupel, A. Panangadan, A. Talukder, and R. Pidva, “Clinical evaluation of a novel interstitial fluid sensor system for remote continuous alcohol monitoring,” IEEE Sensors J.8(1), 71–80 (2008).
[CrossRef]

Guo, X.

X. Guo, A. Mandelis, and B. Zinman, “Applications of ultrasensitive wavelength-modulated differential photothermal radiometry to noninvasive glucose detection in blood serum,” J. Biophotonics6(11-12), 911–919 (2013).
[CrossRef] [PubMed]

X. Guo, A. Mandelis, and B. Zinman, “Non-invasive glucose detection in human skin using wavelength modulated differential laser photothermal radiometry,” Biomed. Opt. Express3, 3012–3021 (2012).
[CrossRef] [PubMed]

A. Mandelis and X. Guo, “Wavelength-modulated differential photothermal radiometry: theory and experimental applications to glucose detection in water,” Phys. Rev. E.84(4), 041917 (2011).
[CrossRef] [PubMed]

Lybrand, S.

C. Willis, S. Lybrand, and N. Bellamy, “Alcohol ignition interlock programmes for reducing drink driving recidivism,” Cochrane Database Syst. Rev.18(4), CD004168 (2004).
[PubMed]

Mandelis, A.

X. Guo, A. Mandelis, and B. Zinman, “Applications of ultrasensitive wavelength-modulated differential photothermal radiometry to noninvasive glucose detection in blood serum,” J. Biophotonics6(11-12), 911–919 (2013).
[CrossRef] [PubMed]

X. Guo, A. Mandelis, and B. Zinman, “Non-invasive glucose detection in human skin using wavelength modulated differential laser photothermal radiometry,” Biomed. Opt. Express3, 3012–3021 (2012).
[CrossRef] [PubMed]

A. Mandelis and X. Guo, “Wavelength-modulated differential photothermal radiometry: theory and experimental applications to glucose detection in water,” Phys. Rev. E.84(4), 041917 (2011).
[CrossRef] [PubMed]

Mongin, D.

M. Venugopal, K. E. Feuvrel, D. Mongin, S. Bambot, M. Faupel, A. Panangadan, A. Talukder, and R. Pidva, “Clinical evaluation of a novel interstitial fluid sensor system for remote continuous alcohol monitoring,” IEEE Sensors J.8(1), 71–80 (2008).
[CrossRef]

Panangadan, A.

M. Venugopal, K. E. Feuvrel, D. Mongin, S. Bambot, M. Faupel, A. Panangadan, A. Talukder, and R. Pidva, “Clinical evaluation of a novel interstitial fluid sensor system for remote continuous alcohol monitoring,” IEEE Sensors J.8(1), 71–80 (2008).
[CrossRef]

Pidva, R.

M. Venugopal, K. E. Feuvrel, D. Mongin, S. Bambot, M. Faupel, A. Panangadan, A. Talukder, and R. Pidva, “Clinical evaluation of a novel interstitial fluid sensor system for remote continuous alcohol monitoring,” IEEE Sensors J.8(1), 71–80 (2008).
[CrossRef]

Talukder, A.

M. Venugopal, K. E. Feuvrel, D. Mongin, S. Bambot, M. Faupel, A. Panangadan, A. Talukder, and R. Pidva, “Clinical evaluation of a novel interstitial fluid sensor system for remote continuous alcohol monitoring,” IEEE Sensors J.8(1), 71–80 (2008).
[CrossRef]

Venugopal, M.

M. Venugopal, K. E. Feuvrel, D. Mongin, S. Bambot, M. Faupel, A. Panangadan, A. Talukder, and R. Pidva, “Clinical evaluation of a novel interstitial fluid sensor system for remote continuous alcohol monitoring,” IEEE Sensors J.8(1), 71–80 (2008).
[CrossRef]

Willis, C.

C. Willis, S. Lybrand, and N. Bellamy, “Alcohol ignition interlock programmes for reducing drink driving recidivism,” Cochrane Database Syst. Rev.18(4), CD004168 (2004).
[PubMed]

Zinman, B.

X. Guo, A. Mandelis, and B. Zinman, “Applications of ultrasensitive wavelength-modulated differential photothermal radiometry to noninvasive glucose detection in blood serum,” J. Biophotonics6(11-12), 911–919 (2013).
[CrossRef] [PubMed]

X. Guo, A. Mandelis, and B. Zinman, “Non-invasive glucose detection in human skin using wavelength modulated differential laser photothermal radiometry,” Biomed. Opt. Express3, 3012–3021 (2012).
[CrossRef] [PubMed]

Biomed. Opt. Express

Cochrane Database Syst. Rev.

C. Willis, S. Lybrand, and N. Bellamy, “Alcohol ignition interlock programmes for reducing drink driving recidivism,” Cochrane Database Syst. Rev.18(4), CD004168 (2004).
[PubMed]

IEEE Sensors J.

M. Venugopal, K. E. Feuvrel, D. Mongin, S. Bambot, M. Faupel, A. Panangadan, A. Talukder, and R. Pidva, “Clinical evaluation of a novel interstitial fluid sensor system for remote continuous alcohol monitoring,” IEEE Sensors J.8(1), 71–80 (2008).
[CrossRef]

J. Biophotonics

X. Guo, A. Mandelis, and B. Zinman, “Applications of ultrasensitive wavelength-modulated differential photothermal radiometry to noninvasive glucose detection in blood serum,” J. Biophotonics6(11-12), 911–919 (2013).
[CrossRef] [PubMed]

Phys. Rev. E.

A. Mandelis and X. Guo, “Wavelength-modulated differential photothermal radiometry: theory and experimental applications to glucose detection in water,” Phys. Rev. E.84(4), 041917 (2011).
[CrossRef] [PubMed]

Other

Traffic Safety Facts, National Highway Traffic Safety Administration, (2013).

S. Perreault, “Impaired driving in Canada, 2011”, Statistics Canada—Catalogue no. 85–002-X, (2013).

S. A. Ferguson, E. Traube, A. Zaouk, and R. Strassburger, “Driver alcohol detection system for safety (DADSS) – a non-regulatory approach in thedevelopment and deployment of vehicle safety technology to reduce alcohol-impaired driving”, in Proceedings of the 21st International Technical Conference on the Enhanced Safety of Vehicles, (Stuttgart, Germany, 2009), pp. 09–0464.

S. A. Ferguson, A. Zaouk, N. Dalal, C. Strohl, E. Traube, and R. Strassburger, “Driver alcohol detection system for safety (DADSS) –phase 1 prototype testing and findings”, in Proceedings of the 22rd International Technical Conference on the Enhanced Safety of Vehicles, (Washington, D.C., US, 2011), pp. 11–0230.

U. S. Department of Transportation National Highway Traffic Safety Administration, J. Pollard, E. Nadler, and M. Stearns, Review of Technology to Prevent Alcohol-Impaired Crashes (TOPIC), (Createspace Independent Pub., 2007)

A. Mandelis and X. Guo, “Method of performing wavelength modulated differential laser photothermal radiometry with high sensitivity,” US Patent No. 08649835 Cl. 600–316, issued on Feb. 11, 2014.

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Figures (9)

Fig. 1
Fig. 1

Infrared ethanol alcohol absorption spectrum (1.4µm to 10 µm).

Fig. 2
Fig. 2

MIR ethyl alcohol fundamental absorption band.

Fig. 3
Fig. 3

Current WM-DPTR system configuration. The variable circular neutral density (ND) filter controls the amplitude ratio R. The function generator controls the phase shift ΔP.

Fig. 4
Fig. 4

schematic diagram of sample holder

Fig. 5
Fig. 5

Single PTR (with laser A and laser B) measurements of ethanol + water solutions at 90 Hz. (a) amplitude AA (AB); (b) phase PA (PB).

Fig. 6
Fig. 6

WM-DPTR signals of ethanol + water solutions measured with various amplitude ratio R and phase shift ΔP combinations. (a) amplitude; (b) phase.

Fig. 7
Fig. 7

WM-DPTR signals of ethanol + serum solutions diffused in human skin measured with different amplitude ratio R and phase shift ΔP combinations. (a) amplitude; (b) phase.

Fig. 8
Fig. 8

WM-DPTR phase signal of ethanol + serum solutions diffused in human skin.

Fig. 9
Fig. 9

Single PTR with laser A measurement of ethanol + serum solutions diffused in the human skin. (a) amplitude; (b) phase.

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