Abstract

Combining two or more imaging modalities to provide complementary information has become commonplace in clinical practice and in preclinical and basic biomedical research. By incorporating the structural information provided by computed tomography (CT) or magnetic resonance imaging (MRI), the ill poseness nature of bioluminescence tomography (BLT) can be reduced significantly, thus improve the accuracies of reconstruction and in vivo quantification. In this paper, we present a small animal imaging system combining multi-view and multi-spectral BLT with MRI. The independent MRI-compatible optical device is placed at the end of the clinical MRI scanner. The small animal is transferred between the light tight chamber of the optical device and the animal coil of MRI via a guide rail during the experiment. After the optical imaging and MRI scanning procedures are finished, the optical images are mapped onto the MRI surface by interactive registration between boundary of optical images and silhouette of MRI. Then, incorporating the MRI structural information, a heterogeneous reconstruction algorithm based on finite element method (FEM) with L1 normalization is used to reconstruct the position, power and region of the light source. In order to validate the feasibility of the system, we conducted experiments of nude mice model implanted with artificial light source and quantitative analysis of tumor inoculation model with MDA-231-GFP-luc. Preliminary results suggest the feasibility and effectiveness of the prototype system.

© 2014 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models

Junting Liu, Yabin Wang, Xiaochao Qu, Xiangsi Li, Xiaopeng Ma, Runqiang Han, Zhenhua Hu, Xueli Chen, Dongdong Sun, Rongqing Zhang, Duofang Chen, Dan Chen, Xiaoyuan Chen, Jimin Liang, Feng Cao, and Jie Tian
Opt. Express 18(12) 13102-13113 (2010)

Early detection of liver cancer based on bioluminescence tomography

Xibo Ma, Jie Tian, Chenghu Qin, Xin Yang, Bo Zhang, Zhenwen Xue, Xing Zhang, Dong Han, Di Dong, and Xueyan Liu
Appl. Opt. 50(10) 1389-1395 (2011)

In vivo mouse studies with bioluminescence tomography

Ge Wang, Wenxiang Cong, Kumar Durairaj, Xin Qian, Haiou Shen, Patrick Sinn, Eric Hoffman, Geoffrey McLennan, and Michael Henry
Opt. Express 14(17) 7801-7809 (2006)

References

  • View by:
  • |
  • |
  • |

  1. M. Baker, “Whole-animal imaging: The whole picture,” Nature 463, 977–980 (2010).
    [Crossref] [PubMed]
  2. F. Stuker, C. Baltes, K. Dikaiou, D. Vats, L. Carrara, E. Charbon, J. Ripoll, and M. Rudin, “Hybrid small animal imaging system combining magnetic resonance imaging with fluorescence tomography using single photon avalanche diode detectors,” IEEE Trans. Med. Imaging 30, 1265–1273 (2011).
    [Crossref] [PubMed]
  3. T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
    [PubMed]
  4. O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
    [Crossref] [PubMed]
  5. S. R. Cherry, “Multimodality imaging: Beyond pet/ct and spect/ct,” in Seminars in Nuclear Medicine,, vol. 39 (Elsevier, 2009), vol. 39, pp. 348–353.
    [Crossref]
  6. M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
    [Crossref] [PubMed]
  7. B. J. Pichler, A. Kolb, T. Nägele, and H.-P. Schlemmer, “Pet/mri: paving the way for the next generation of clinical multimodality imaging applications,” J. Nucl. Med 51, 333–336 (2010).
    [Crossref] [PubMed]
  8. O. Ratib and T. Beyer, “Whole-body hybrid pet/mri: ready for clinical use?” Eur. J. Nucl. Med. Mol. Imaging 38, 992–995 (2011).
    [Crossref] [PubMed]
  9. K. Licha and C. Olbrich, “Optical imaging in drug discovery and diagnostic applications,” Adv. Drug Delivery Rev. 57, 1087–1108 (2005).
    [Crossref]
  10. H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
    [Crossref] [PubMed]
  11. S. Jiang, M. K. Gnanasammandhan, and Y. Zhang, “Optical imaging-guided cancer therapy with fluorescent nanoparticles,” J. R. Soc., Interface 7, 3–18 (2010).
    [Crossref]
  12. S. Cho, S. Kim, Y. Kim, and Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30, 71–79 (2012).
    [Crossref]
  13. J. K. Willmann, N. van Bruggen, L. M. Dinkelborg, and S. S. Gambhir, “Molecular imaging in drug development,” Nat. Rev. Drug Discovery 7, 591–607 (2008).
    [Crossref]
  14. A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “Fmt-xct: in vivo animal studies with hybrid fluorescence molecular tomography-x-ray computed tomography,” Nat. Meth. 9, 615–620 (2012).
    [Crossref]
  15. G. Wang, W. Cong, K. Durairaj, X. Qian, H. Shen, P. Sinn, E. Hoffman, G. McLennan, and M. Henry, “In vivo mouse studies with bioluminescence tomography,” Opt. Express 14, 7801–7809 (2006).
    [Crossref] [PubMed]
  16. J. Zhong, J. Tian, X. Yang, and C. Qin, “Whole-body cerenkov luminescence tomography with the finite element sp3 method,” Ann. Biomed. Eng. 39, 1728–1735 (2011).
    [Crossref] [PubMed]
  17. Y. Lv, J. Tian, W. Cong, G. Wang, W. Yang, C. Qin, and M. Xu, “Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation,” Phys. Med. Biol. 52, 4497 (2007).
    [Crossref] [PubMed]
  18. J. Liu, Y. Wang, X. Qu, X. Li, X. Ma, R. Han, Z. Hu, X. Chen, D. Sun, R. Zhang, and et al., “In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models,” Opt. Express 18, 13102 (2010).
    [Crossref] [PubMed]
  19. J. Tian, K. Liu, Y. Lu, C. Qin, X. Yang, S. Zhu, D. Han, J. Feng, X. Ma, and Z. Chang, “Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models,” Opt. Express 18, 20988–21002 (2010).
    [Crossref] [PubMed]
  20. M. A. Naser and M. S. Patterson, “Bioluminescence tomography using eigenvectors expansion and iterative solution for the optimized permissible source region,” Biomed. Opt. Express 2, 3179–3193 (2011).
    [Crossref] [PubMed]
  21. Q. Zhang, X. Chen, X. Qu, J. Liang, and J. Tian, “Comparative studies of lp-regularization-based reconstruction algorithms for bioluminescence tomography,” Biomed. Opt. Express 3, 2916–2936 (2012).
    [Crossref] [PubMed]
  22. K. Brindle, “New approaches for imaging tumour responses to treatment,” Nat. Rev. Cancer 8, 94–107 (2008).
    [Crossref] [PubMed]
  23. M. Allard, D. Côté, L. Davidson, J. Dazai, and R. M. Henkelman, “Combined magnetic resonance and bioluminescence imaging of live mice,” J. Biomed. Opt. 12, 034018 (2007).
    [Crossref] [PubMed]
  24. M. B. Unlu, Y. Lin, O. Birgul, O. Nalcioglu, and G. Gulsen, “Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging,” J. Biomed. Opt. 13, 060501 (2008).
    [Crossref]
  25. R. Gong, G. Wang, X. Cheng, and W. Han, “A novel approach for studies of multispectral bioluminescence tomography,” Numerische Mathematik 115, 553–583 (2010).
    [Crossref]
  26. W. Cong, G. Wang, D. Kumar, Y. Liu, M. Jiang, L. V. Wang, E. A. Hoffman, G. McLennan, P. B. McCray, J. Zabner, and et al., “Practical reconstruction method for bioluminescence tomography,” Opt. Express 13, 6756–6771 (2005).
    [Crossref] [PubMed]
  27. V. Ntziachristos, A. Yodh, M. Schnall, and B. Chance, “Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement,” Proc. Nat. Acad. Sci. USA 97, 2767–2772 (2000).
    [Crossref] [PubMed]
  28. B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
    [Crossref] [PubMed]
  29. B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (nir) tomography breast image reconstruction with a priori structural information from mri: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9, 199–209 (2003).
    [Crossref]
  30. R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
    [Crossref] [PubMed]
  31. S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
    [Crossref]
  32. S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer mri-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Nat. Acad. Sci. USA 110, 9025–9030 (2013).
    [Crossref] [PubMed]
  33. G. Wang, H. Shen, K. Durairaj, X. Qian, and W. Cong, “The first bioluminescence tomography system for simultaneous acquisition of multiview and multispectral data,” Int. J. Biomed. Imaging 2006, 58601 (2006).
    [Crossref] [PubMed]
  34. A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging,” Phys. Med. Biol. 50, 5421 (2005).
    [Crossref] [PubMed]
  35. E. M. Hillman and A. Moore, “All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast,” Nat. Photonics 1, 526–530 (2007).
    [Crossref]
  36. S. Arridge, M. Schweiger, M. Hiraoka, and D. Delpy, “A finite element approach for modeling photon transport in tissue,” Med. Phys. 20, 299 (1993).
    [Crossref] [PubMed]
  37. V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, “Fluorescence molecular tomography resolves protease activity in vivo,” Nat. Med. 8, 757–761 (2002).
    [Crossref] [PubMed]
  38. R. B. Schulz, J. Ripoll, and V. Ntziachristos, “Experimental fluorescence tomography of tissues with noncontact measurements,” IEEE Trans. Med. Imaging 23, 492–500 (2004).
    [Crossref] [PubMed]
  39. G. S. Abdoulaev and A. H. Hielscher, “Three-dimensional optical tomography with the equation of radiative transfer,” J. Electron. Imaging 12, 594–601 (2003).
    [Crossref]
  40. T. Tarvainen, M. Vauhkonen, V. Kolehmainen, and J. Kaipio, “Finite element model for the coupled radiative transfer equation and diffusion approximation,” Int. J. Numerical Methods Engineering 65, 383–405 (2006).
    [Crossref]
  41. A. D. Klose and E. W. Larsen, “Light transport in biological tissue based on the simplified spherical harmonics equations,” J. Comput. Phys. 220, 441–470 (2006).
    [Crossref]
  42. S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41 (1999).
    [Crossref]
  43. A. J. Welch and M. J. Van Gemert, Optical-Thermal Response of Laser-Irradiated Tissue (Springer, 2010).
  44. B. W. Pogue, S. Geimer, T. O. McBride, S. Jiang, U. L. Österberg, and K. D. Paulsen, “Three-dimensional simulation of near-infrared diffusion in tissue: boundary condition and geometry analysis for finite-element image reconstruction,” Appl. Opt. 40, 588–600 (2001).
    [Crossref]
  45. M. Schweiger, S. Arridge, M. Hiraoka, and D. Delpy, “The finite element method for the propagation of light in scattering media: boundary and source conditions,” Med. Phys. 22, 1779 (1995).
    [Crossref] [PubMed]
  46. J. J. Duderstadt and L. J. Hamilton, “Nuclear reactor analysis,” (1976).
  47. Y. Lv, J. Tian, W. Cong, G. Wang, J. Luo, W. Yang, and H. Li, “A multilevel adaptive finite element algorithm for bioluminescence tomography,” Opt. Express 14, 8211–8223 (2006).
    [Crossref] [PubMed]
  48. R. Han, J. Liang, X. Qu, Y. Hou, N. Ren, J. Mao, and J. Tian, “A source reconstruction algorithm based on adaptive hp-fem for bioluminescence tomography,” Opt. Express 17, 14481–14494 (2009).
    [Crossref] [PubMed]
  49. S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, “Fast iterative image reconstruction methods for fully 3d multispectral bioluminescence tomography,” Phys. Med. Biol. 53, 3921 (2008).
    [Crossref] [PubMed]
  50. G. Wang, Y. Li, and M. Jiang, “Uniqueness theorems in bioluminescence tomography,” Med. Phys. 31, 2289 (2004).
    [Crossref] [PubMed]
  51. A. X. Cong and G. Wang, “Multispectral bioluminescence tomography: methodology and simulation,” Int. J. Biomed. Imaging 2006, 57614 (2006).
    [Crossref] [PubMed]
  52. B. Zhang, X. Yang, C. Qin, D. Liu, S. Zhu, J. Feng, L. Sun, K. Liu, D. Han, X. Ma, and et al., “A trust region method in adaptive finite element framework for bioluminescence tomography,” Opt. Express 18, 6477–6491 (2010).
    [Crossref] [PubMed]
  53. J. Feng, C. Qin, K. Jia, S. Zhu, X. Yang, and J. Tian, “Bioluminescence tomography imaging in vivo: recent advances,” IEEE J. Sel. Top. Quantum Electron. 18, 1394–1402 (2012).
    [Crossref]
  54. P. Arbelaez, M. Maire, C. Fowlkes, and J. Malik, “Contour detection and hierarchical image segmentation,” IEEE Trans. Pattern Analysis and Machine Intelligence 33, 898–916 (2011).
    [Crossref]
  55. S. Ren, X. Chen, H. Wang, X. Qu, G. Wang, J. Liang, and J. Tian, “Molecular optical simulation environment (mose): A platform for the simulation of light propagation in turbid media,” PloS one 8, e61304 (2013).
    [Crossref] [PubMed]
  56. G. Alexandrakis, F. R. Rannou, and A. F. Chatziioannou, “Tomographic bioluminescence imaging by use of a combined optical-pet (opet) system: a computer simulation feasibility study,” Phys. Med. Biol. 50, 4225 (2005).
    [Crossref] [PubMed]
  57. D. E. Jenkins, Y. Oei, Y. S. Hornig, S.-F. Yu, J. Dusich, T. Purchio, and P. R. Contag, “Bioluminescent imaging (bli) to improve and refine traditional murine models of tumor growth and metastasis,” Clin. Exp. Metastasis 20, 733–744 (2003).
    [Crossref]

2013 (3)

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer mri-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Nat. Acad. Sci. USA 110, 9025–9030 (2013).
[Crossref] [PubMed]

S. Ren, X. Chen, H. Wang, X. Qu, G. Wang, J. Liang, and J. Tian, “Molecular optical simulation environment (mose): A platform for the simulation of light propagation in turbid media,” PloS one 8, e61304 (2013).
[Crossref] [PubMed]

2012 (4)

J. Feng, C. Qin, K. Jia, S. Zhu, X. Yang, and J. Tian, “Bioluminescence tomography imaging in vivo: recent advances,” IEEE J. Sel. Top. Quantum Electron. 18, 1394–1402 (2012).
[Crossref]

Q. Zhang, X. Chen, X. Qu, J. Liang, and J. Tian, “Comparative studies of lp-regularization-based reconstruction algorithms for bioluminescence tomography,” Biomed. Opt. Express 3, 2916–2936 (2012).
[Crossref] [PubMed]

S. Cho, S. Kim, Y. Kim, and Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30, 71–79 (2012).
[Crossref]

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “Fmt-xct: in vivo animal studies with hybrid fluorescence molecular tomography-x-ray computed tomography,” Nat. Meth. 9, 615–620 (2012).
[Crossref]

2011 (5)

J. Zhong, J. Tian, X. Yang, and C. Qin, “Whole-body cerenkov luminescence tomography with the finite element sp3 method,” Ann. Biomed. Eng. 39, 1728–1735 (2011).
[Crossref] [PubMed]

F. Stuker, C. Baltes, K. Dikaiou, D. Vats, L. Carrara, E. Charbon, J. Ripoll, and M. Rudin, “Hybrid small animal imaging system combining magnetic resonance imaging with fluorescence tomography using single photon avalanche diode detectors,” IEEE Trans. Med. Imaging 30, 1265–1273 (2011).
[Crossref] [PubMed]

O. Ratib and T. Beyer, “Whole-body hybrid pet/mri: ready for clinical use?” Eur. J. Nucl. Med. Mol. Imaging 38, 992–995 (2011).
[Crossref] [PubMed]

M. A. Naser and M. S. Patterson, “Bioluminescence tomography using eigenvectors expansion and iterative solution for the optimized permissible source region,” Biomed. Opt. Express 2, 3179–3193 (2011).
[Crossref] [PubMed]

P. Arbelaez, M. Maire, C. Fowlkes, and J. Malik, “Contour detection and hierarchical image segmentation,” IEEE Trans. Pattern Analysis and Machine Intelligence 33, 898–916 (2011).
[Crossref]

2010 (7)

B. Zhang, X. Yang, C. Qin, D. Liu, S. Zhu, J. Feng, L. Sun, K. Liu, D. Han, X. Ma, and et al., “A trust region method in adaptive finite element framework for bioluminescence tomography,” Opt. Express 18, 6477–6491 (2010).
[Crossref] [PubMed]

J. Liu, Y. Wang, X. Qu, X. Li, X. Ma, R. Han, Z. Hu, X. Chen, D. Sun, R. Zhang, and et al., “In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models,” Opt. Express 18, 13102 (2010).
[Crossref] [PubMed]

J. Tian, K. Liu, Y. Lu, C. Qin, X. Yang, S. Zhu, D. Han, J. Feng, X. Ma, and Z. Chang, “Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models,” Opt. Express 18, 20988–21002 (2010).
[Crossref] [PubMed]

B. J. Pichler, A. Kolb, T. Nägele, and H.-P. Schlemmer, “Pet/mri: paving the way for the next generation of clinical multimodality imaging applications,” J. Nucl. Med 51, 333–336 (2010).
[Crossref] [PubMed]

M. Baker, “Whole-animal imaging: The whole picture,” Nature 463, 977–980 (2010).
[Crossref] [PubMed]

S. Jiang, M. K. Gnanasammandhan, and Y. Zhang, “Optical imaging-guided cancer therapy with fluorescent nanoparticles,” J. R. Soc., Interface 7, 3–18 (2010).
[Crossref]

R. Gong, G. Wang, X. Cheng, and W. Han, “A novel approach for studies of multispectral bioluminescence tomography,” Numerische Mathematik 115, 553–583 (2010).
[Crossref]

2009 (1)

2008 (6)

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, “Fast iterative image reconstruction methods for fully 3d multispectral bioluminescence tomography,” Phys. Med. Biol. 53, 3921 (2008).
[Crossref] [PubMed]

M. B. Unlu, Y. Lin, O. Birgul, O. Nalcioglu, and G. Gulsen, “Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging,” J. Biomed. Opt. 13, 060501 (2008).
[Crossref]

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[Crossref]

J. K. Willmann, N. van Bruggen, L. M. Dinkelborg, and S. S. Gambhir, “Molecular imaging in drug development,” Nat. Rev. Drug Discovery 7, 591–607 (2008).
[Crossref]

K. Brindle, “New approaches for imaging tumour responses to treatment,” Nat. Rev. Cancer 8, 94–107 (2008).
[Crossref] [PubMed]

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

2007 (4)

O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
[Crossref] [PubMed]

M. Allard, D. Côté, L. Davidson, J. Dazai, and R. M. Henkelman, “Combined magnetic resonance and bioluminescence imaging of live mice,” J. Biomed. Opt. 12, 034018 (2007).
[Crossref] [PubMed]

Y. Lv, J. Tian, W. Cong, G. Wang, W. Yang, C. Qin, and M. Xu, “Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation,” Phys. Med. Biol. 52, 4497 (2007).
[Crossref] [PubMed]

E. M. Hillman and A. Moore, “All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast,” Nat. Photonics 1, 526–530 (2007).
[Crossref]

2006 (7)

T. Tarvainen, M. Vauhkonen, V. Kolehmainen, and J. Kaipio, “Finite element model for the coupled radiative transfer equation and diffusion approximation,” Int. J. Numerical Methods Engineering 65, 383–405 (2006).
[Crossref]

A. D. Klose and E. W. Larsen, “Light transport in biological tissue based on the simplified spherical harmonics equations,” J. Comput. Phys. 220, 441–470 (2006).
[Crossref]

G. Wang, H. Shen, K. Durairaj, X. Qian, and W. Cong, “The first bioluminescence tomography system for simultaneous acquisition of multiview and multispectral data,” Int. J. Biomed. Imaging 2006, 58601 (2006).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
[Crossref] [PubMed]

A. X. Cong and G. Wang, “Multispectral bioluminescence tomography: methodology and simulation,” Int. J. Biomed. Imaging 2006, 57614 (2006).
[Crossref] [PubMed]

G. Wang, W. Cong, K. Durairaj, X. Qian, H. Shen, P. Sinn, E. Hoffman, G. McLennan, and M. Henry, “In vivo mouse studies with bioluminescence tomography,” Opt. Express 14, 7801–7809 (2006).
[Crossref] [PubMed]

Y. Lv, J. Tian, W. Cong, G. Wang, J. Luo, W. Yang, and H. Li, “A multilevel adaptive finite element algorithm for bioluminescence tomography,” Opt. Express 14, 8211–8223 (2006).
[Crossref] [PubMed]

2005 (5)

W. Cong, G. Wang, D. Kumar, Y. Liu, M. Jiang, L. V. Wang, E. A. Hoffman, G. McLennan, P. B. McCray, J. Zabner, and et al., “Practical reconstruction method for bioluminescence tomography,” Opt. Express 13, 6756–6771 (2005).
[Crossref] [PubMed]

G. Alexandrakis, F. R. Rannou, and A. F. Chatziioannou, “Tomographic bioluminescence imaging by use of a combined optical-pet (opet) system: a computer simulation feasibility study,” Phys. Med. Biol. 50, 4225 (2005).
[Crossref] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging,” Phys. Med. Biol. 50, 5421 (2005).
[Crossref] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

K. Licha and C. Olbrich, “Optical imaging in drug discovery and diagnostic applications,” Adv. Drug Delivery Rev. 57, 1087–1108 (2005).
[Crossref]

2004 (2)

R. B. Schulz, J. Ripoll, and V. Ntziachristos, “Experimental fluorescence tomography of tissues with noncontact measurements,” IEEE Trans. Med. Imaging 23, 492–500 (2004).
[Crossref] [PubMed]

G. Wang, Y. Li, and M. Jiang, “Uniqueness theorems in bioluminescence tomography,” Med. Phys. 31, 2289 (2004).
[Crossref] [PubMed]

2003 (3)

D. E. Jenkins, Y. Oei, Y. S. Hornig, S.-F. Yu, J. Dusich, T. Purchio, and P. R. Contag, “Bioluminescent imaging (bli) to improve and refine traditional murine models of tumor growth and metastasis,” Clin. Exp. Metastasis 20, 733–744 (2003).
[Crossref]

G. S. Abdoulaev and A. H. Hielscher, “Three-dimensional optical tomography with the equation of radiative transfer,” J. Electron. Imaging 12, 594–601 (2003).
[Crossref]

B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (nir) tomography breast image reconstruction with a priori structural information from mri: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9, 199–209 (2003).
[Crossref]

2002 (1)

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, “Fluorescence molecular tomography resolves protease activity in vivo,” Nat. Med. 8, 757–761 (2002).
[Crossref] [PubMed]

2001 (1)

2000 (2)

V. Ntziachristos, A. Yodh, M. Schnall, and B. Chance, “Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement,” Proc. Nat. Acad. Sci. USA 97, 2767–2772 (2000).
[Crossref] [PubMed]

T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
[PubMed]

1999 (1)

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41 (1999).
[Crossref]

1995 (1)

M. Schweiger, S. Arridge, M. Hiraoka, and D. Delpy, “The finite element method for the propagation of light in scattering media: boundary and source conditions,” Med. Phys. 22, 1779 (1995).
[Crossref] [PubMed]

1993 (1)

S. Arridge, M. Schweiger, M. Hiraoka, and D. Delpy, “A finite element approach for modeling photon transport in tissue,” Med. Phys. 20, 299 (1993).
[Crossref] [PubMed]

Abdoulaev, G. S.

G. S. Abdoulaev and A. H. Hielscher, “Three-dimensional optical tomography with the equation of radiative transfer,” J. Electron. Imaging 12, 594–601 (2003).
[Crossref]

Ahn, S.

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, “Fast iterative image reconstruction methods for fully 3d multispectral bioluminescence tomography,” Phys. Med. Biol. 53, 3921 (2008).
[Crossref] [PubMed]

Ale, A.

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “Fmt-xct: in vivo animal studies with hybrid fluorescence molecular tomography-x-ray computed tomography,” Nat. Meth. 9, 615–620 (2012).
[Crossref]

Alexandrakis, G.

G. Alexandrakis, F. R. Rannou, and A. F. Chatziioannou, “Tomographic bioluminescence imaging by use of a combined optical-pet (opet) system: a computer simulation feasibility study,” Phys. Med. Biol. 50, 4225 (2005).
[Crossref] [PubMed]

Alkadhi, H.

O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
[Crossref] [PubMed]

Allard, M.

M. Allard, D. Côté, L. Davidson, J. Dazai, and R. M. Henkelman, “Combined magnetic resonance and bioluminescence imaging of live mice,” J. Biomed. Opt. 12, 034018 (2007).
[Crossref] [PubMed]

Arbelaez, P.

P. Arbelaez, M. Maire, C. Fowlkes, and J. Malik, “Contour detection and hierarchical image segmentation,” IEEE Trans. Pattern Analysis and Machine Intelligence 33, 898–916 (2011).
[Crossref]

Arridge, S.

M. Schweiger, S. Arridge, M. Hiraoka, and D. Delpy, “The finite element method for the propagation of light in scattering media: boundary and source conditions,” Med. Phys. 22, 1779 (1995).
[Crossref] [PubMed]

S. Arridge, M. Schweiger, M. Hiraoka, and D. Delpy, “A finite element approach for modeling photon transport in tissue,” Med. Phys. 20, 299 (1993).
[Crossref] [PubMed]

Arridge, S. R.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41 (1999).
[Crossref]

Ashitate, Y.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Bading, J. R.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging,” Phys. Med. Biol. 50, 5421 (2005).
[Crossref] [PubMed]

Bae, S.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Baker, M.

M. Baker, “Whole-animal imaging: The whole picture,” Nature 463, 977–980 (2010).
[Crossref] [PubMed]

Baltes, C.

F. Stuker, C. Baltes, K. Dikaiou, D. Vats, L. Carrara, E. Charbon, J. Ripoll, and M. Rudin, “Hybrid small animal imaging system combining magnetic resonance imaging with fluorescence tomography using single photon avalanche diode detectors,” IEEE Trans. Med. Imaging 30, 1265–1273 (2011).
[Crossref] [PubMed]

Becker, M.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Beyer, T.

O. Ratib and T. Beyer, “Whole-body hybrid pet/mri: ready for clinical use?” Eur. J. Nucl. Med. Mol. Imaging 38, 992–995 (2011).
[Crossref] [PubMed]

T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
[PubMed]

Birgul, O.

M. B. Unlu, Y. Lin, O. Birgul, O. Nalcioglu, and G. Gulsen, “Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging,” J. Biomed. Opt. 13, 060501 (2008).
[Crossref]

Bouman, C. A.

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, “Fast iterative image reconstruction methods for fully 3d multispectral bioluminescence tomography,” Phys. Med. Biol. 53, 3921 (2008).
[Crossref] [PubMed]

Bremer, C.

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, “Fluorescence molecular tomography resolves protease activity in vivo,” Nat. Med. 8, 757–761 (2002).
[Crossref] [PubMed]

Brindle, K.

K. Brindle, “New approaches for imaging tumour responses to treatment,” Nat. Rev. Cancer 8, 94–107 (2008).
[Crossref] [PubMed]

Brooksby, B.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
[Crossref] [PubMed]

Brooksby, B. A.

B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (nir) tomography breast image reconstruction with a priori structural information from mri: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9, 199–209 (2003).
[Crossref]

Brun, T.

T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
[PubMed]

Byars, L.

T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
[PubMed]

Carrara, L.

F. Stuker, C. Baltes, K. Dikaiou, D. Vats, L. Carrara, E. Charbon, J. Ripoll, and M. Rudin, “Hybrid small animal imaging system combining magnetic resonance imaging with fluorescence tomography using single photon avalanche diode detectors,” IEEE Trans. Med. Imaging 30, 1265–1273 (2011).
[Crossref] [PubMed]

Catana, C.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Chance, B.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

V. Ntziachristos, A. Yodh, M. Schnall, and B. Chance, “Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement,” Proc. Nat. Acad. Sci. USA 97, 2767–2772 (2000).
[Crossref] [PubMed]

Chang, Z.

Charbon, E.

F. Stuker, C. Baltes, K. Dikaiou, D. Vats, L. Carrara, E. Charbon, J. Ripoll, and M. Rudin, “Hybrid small animal imaging system combining magnetic resonance imaging with fluorescence tomography using single photon avalanche diode detectors,” IEEE Trans. Med. Imaging 30, 1265–1273 (2011).
[Crossref] [PubMed]

Charron, M.

T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
[PubMed]

Chatziioannou, A. F.

G. Alexandrakis, F. R. Rannou, and A. F. Chatziioannou, “Tomographic bioluminescence imaging by use of a combined optical-pet (opet) system: a computer simulation feasibility study,” Phys. Med. Biol. 50, 4225 (2005).
[Crossref] [PubMed]

Chaudhari, A. J.

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, “Fast iterative image reconstruction methods for fully 3d multispectral bioluminescence tomography,” Phys. Med. Biol. 53, 3921 (2008).
[Crossref] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging,” Phys. Med. Biol. 50, 5421 (2005).
[Crossref] [PubMed]

Chen, X.

Cheng, X.

R. Gong, G. Wang, X. Cheng, and W. Han, “A novel approach for studies of multispectral bioluminescence tomography,” Numerische Mathematik 115, 553–583 (2010).
[Crossref]

Cherry, S. R.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging,” Phys. Med. Biol. 50, 5421 (2005).
[Crossref] [PubMed]

S. R. Cherry, “Multimodality imaging: Beyond pet/ct and spect/ct,” in Seminars in Nuclear Medicine,, vol. 39 (Elsevier, 2009), vol. 39, pp. 348–353.
[Crossref]

Cho, S.

S. Cho, S. Kim, Y. Kim, and Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30, 71–79 (2012).
[Crossref]

Choe, R.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

Choi, H. S.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Claussen, C. D.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Cohrs, C.

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “Fmt-xct: in vivo animal studies with hybrid fluorescence molecular tomography-x-ray computed tomography,” Nat. Meth. 9, 615–620 (2012).
[Crossref]

Cong, A. X.

A. X. Cong and G. Wang, “Multispectral bioluminescence tomography: methodology and simulation,” Int. J. Biomed. Imaging 2006, 57614 (2006).
[Crossref] [PubMed]

Cong, W.

Contag, P. R.

D. E. Jenkins, Y. Oei, Y. S. Hornig, S.-F. Yu, J. Dusich, T. Purchio, and P. R. Contag, “Bioluminescent imaging (bli) to improve and refine traditional murine models of tumor growth and metastasis,” Clin. Exp. Metastasis 20, 733–744 (2003).
[Crossref]

Conti, P. S.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging,” Phys. Med. Biol. 50, 5421 (2005).
[Crossref] [PubMed]

Corlu, A.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

Côté, D.

M. Allard, D. Côté, L. Davidson, J. Dazai, and R. M. Henkelman, “Combined magnetic resonance and bioluminescence imaging of live mice,” J. Biomed. Opt. 12, 034018 (2007).
[Crossref] [PubMed]

Czerniecki, B. J.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

Darvas, F.

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, “Fast iterative image reconstruction methods for fully 3d multispectral bioluminescence tomography,” Phys. Med. Biol. 53, 3921 (2008).
[Crossref] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging,” Phys. Med. Biol. 50, 5421 (2005).
[Crossref] [PubMed]

Davidson, L.

M. Allard, D. Côté, L. Davidson, J. Dazai, and R. M. Henkelman, “Combined magnetic resonance and bioluminescence imaging of live mice,” J. Biomed. Opt. 12, 034018 (2007).
[Crossref] [PubMed]

Davis, S. C.

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer mri-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Nat. Acad. Sci. USA 110, 9025–9030 (2013).
[Crossref] [PubMed]

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[Crossref]

Dazai, J.

M. Allard, D. Côté, L. Davidson, J. Dazai, and R. M. Henkelman, “Combined magnetic resonance and bioluminescence imaging of live mice,” J. Biomed. Opt. 12, 034018 (2007).
[Crossref] [PubMed]

de Angelis, M. H.

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “Fmt-xct: in vivo animal studies with hybrid fluorescence molecular tomography-x-ray computed tomography,” Nat. Meth. 9, 615–620 (2012).
[Crossref]

Deharvengt, S. J.

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer mri-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Nat. Acad. Sci. USA 110, 9025–9030 (2013).
[Crossref] [PubMed]

Dehghani, H.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[Crossref]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
[Crossref] [PubMed]

B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (nir) tomography breast image reconstruction with a priori structural information from mri: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9, 199–209 (2003).
[Crossref]

Delpy, D.

M. Schweiger, S. Arridge, M. Hiraoka, and D. Delpy, “The finite element method for the propagation of light in scattering media: boundary and source conditions,” Med. Phys. 22, 1779 (1995).
[Crossref] [PubMed]

S. Arridge, M. Schweiger, M. Hiraoka, and D. Delpy, “A finite element approach for modeling photon transport in tissue,” Med. Phys. 20, 299 (1993).
[Crossref] [PubMed]

DeMichele, A.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

Dikaiou, K.

F. Stuker, C. Baltes, K. Dikaiou, D. Vats, L. Carrara, E. Charbon, J. Ripoll, and M. Rudin, “Hybrid small animal imaging system combining magnetic resonance imaging with fluorescence tomography using single photon avalanche diode detectors,” IEEE Trans. Med. Imaging 30, 1265–1273 (2011).
[Crossref] [PubMed]

Dinkelborg, L. M.

J. K. Willmann, N. van Bruggen, L. M. Dinkelborg, and S. S. Gambhir, “Molecular imaging in drug development,” Nat. Rev. Drug Discovery 7, 591–607 (2008).
[Crossref]

Duderstadt, J. J.

J. J. Duderstadt and L. J. Hamilton, “Nuclear reactor analysis,” (1976).

Duerst, V.

O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
[Crossref] [PubMed]

Durairaj, K.

G. Wang, W. Cong, K. Durairaj, X. Qian, H. Shen, P. Sinn, E. Hoffman, G. McLennan, and M. Henry, “In vivo mouse studies with bioluminescence tomography,” Opt. Express 14, 7801–7809 (2006).
[Crossref] [PubMed]

G. Wang, H. Shen, K. Durairaj, X. Qian, and W. Cong, “The first bioluminescence tomography system for simultaneous acquisition of multiview and multispectral data,” Int. J. Biomed. Imaging 2006, 58601 (2006).
[Crossref] [PubMed]

Durduran, T.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

Dusich, J.

D. E. Jenkins, Y. Oei, Y. S. Hornig, S.-F. Yu, J. Dusich, T. Purchio, and P. R. Contag, “Bioluminescent imaging (bli) to improve and refine traditional murine models of tumor growth and metastasis,” Clin. Exp. Metastasis 20, 733–744 (2003).
[Crossref]

Eberli, F. R.

O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
[Crossref] [PubMed]

Eichner, M.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Ermolayev, V.

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “Fmt-xct: in vivo animal studies with hybrid fluorescence molecular tomography-x-ray computed tomography,” Nat. Meth. 9, 615–620 (2012).
[Crossref]

Feng, J.

Fowlkes, C.

P. Arbelaez, M. Maire, C. Fowlkes, and J. Malik, “Contour detection and hierarchical image segmentation,” IEEE Trans. Pattern Analysis and Machine Intelligence 33, 898–916 (2011).
[Crossref]

Fraker, D. L.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

Frangioni, J. V.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Gaemperli, O.

O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
[Crossref] [PubMed]

Gambhir, S. S.

J. K. Willmann, N. van Bruggen, L. M. Dinkelborg, and S. S. Gambhir, “Molecular imaging in drug development,” Nat. Rev. Drug Discovery 7, 591–607 (2008).
[Crossref]

Geimer, S.

Gibbs, S. L.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Gibbs-Strauss, S. L.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[Crossref]

Gnanasammandhan, M. K.

S. Jiang, M. K. Gnanasammandhan, and Y. Zhang, “Optical imaging-guided cancer therapy with fluorescent nanoparticles,” J. R. Soc., Interface 7, 3–18 (2010).
[Crossref]

Gong, R.

R. Gong, G. Wang, X. Cheng, and W. Han, “A novel approach for studies of multispectral bioluminescence tomography,” Numerische Mathematik 115, 553–583 (2010).
[Crossref]

Grosicka-Koptyra, M.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

Gulsen, G.

M. B. Unlu, Y. Lin, O. Birgul, O. Nalcioglu, and G. Gulsen, “Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging,” J. Biomed. Opt. 13, 060501 (2008).
[Crossref]

Gunn, J. R.

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer mri-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Nat. Acad. Sci. USA 110, 9025–9030 (2013).
[Crossref] [PubMed]

Hamilton, L. J.

J. J. Duderstadt and L. J. Hamilton, “Nuclear reactor analysis,” (1976).

Han, D.

Han, R.

Han, W.

R. Gong, G. Wang, X. Cheng, and W. Han, “A novel approach for studies of multispectral bioluminescence tomography,” Numerische Mathematik 115, 553–583 (2010).
[Crossref]

Hasan, T.

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer mri-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Nat. Acad. Sci. USA 110, 9025–9030 (2013).
[Crossref] [PubMed]

Henary, M.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Henkelman, R. M.

M. Allard, D. Côté, L. Davidson, J. Dazai, and R. M. Henkelman, “Combined magnetic resonance and bioluminescence imaging of live mice,” J. Biomed. Opt. 12, 034018 (2007).
[Crossref] [PubMed]

Henry, M.

Herzog, E.

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “Fmt-xct: in vivo animal studies with hybrid fluorescence molecular tomography-x-ray computed tomography,” Nat. Meth. 9, 615–620 (2012).
[Crossref]

Hielscher, A. H.

G. S. Abdoulaev and A. H. Hielscher, “Three-dimensional optical tomography with the equation of radiative transfer,” J. Electron. Imaging 12, 594–601 (2003).
[Crossref]

Hillman, E. M.

E. M. Hillman and A. Moore, “All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast,” Nat. Photonics 1, 526–530 (2007).
[Crossref]

Hiraoka, M.

M. Schweiger, S. Arridge, M. Hiraoka, and D. Delpy, “The finite element method for the propagation of light in scattering media: boundary and source conditions,” Med. Phys. 22, 1779 (1995).
[Crossref] [PubMed]

S. Arridge, M. Schweiger, M. Hiraoka, and D. Delpy, “A finite element approach for modeling photon transport in tissue,” Med. Phys. 20, 299 (1993).
[Crossref] [PubMed]

Hoffman, E.

Hoffman, E. A.

Hornig, Y. S.

D. E. Jenkins, Y. Oei, Y. S. Hornig, S.-F. Yu, J. Dusich, T. Purchio, and P. R. Contag, “Bioluminescent imaging (bli) to improve and refine traditional murine models of tumor growth and metastasis,” Clin. Exp. Metastasis 20, 733–744 (2003).
[Crossref]

Hou, Y.

Hu, Z.

Husmann, L.

O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
[Crossref] [PubMed]

Hyun, H.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Jenkins, D. E.

D. E. Jenkins, Y. Oei, Y. S. Hornig, S.-F. Yu, J. Dusich, T. Purchio, and P. R. Contag, “Bioluminescent imaging (bli) to improve and refine traditional murine models of tumor growth and metastasis,” Clin. Exp. Metastasis 20, 733–744 (2003).
[Crossref]

Jerin, J.

T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
[PubMed]

Jia, K.

J. Feng, C. Qin, K. Jia, S. Zhu, X. Yang, and J. Tian, “Bioluminescence tomography imaging in vivo: recent advances,” IEEE J. Sel. Top. Quantum Electron. 18, 1394–1402 (2012).
[Crossref]

Jiang, M.

Jiang, S.

S. Jiang, M. K. Gnanasammandhan, and Y. Zhang, “Optical imaging-guided cancer therapy with fluorescent nanoparticles,” J. R. Soc., Interface 7, 3–18 (2010).
[Crossref]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
[Crossref] [PubMed]

B. W. Pogue, S. Geimer, T. O. McBride, S. Jiang, U. L. Österberg, and K. D. Paulsen, “Three-dimensional simulation of near-infrared diffusion in tissue: boundary condition and geometry analysis for finite-element image reconstruction,” Appl. Opt. 40, 588–600 (2001).
[Crossref]

Jiang, S. S.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[Crossref]

Judenhofer, M. S.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Kaipio, J.

T. Tarvainen, M. Vauhkonen, V. Kolehmainen, and J. Kaipio, “Finite element model for the coupled radiative transfer equation and diffusion approximation,” Int. J. Numerical Methods Engineering 65, 383–405 (2006).
[Crossref]

Kaufmann, P. A.

O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
[Crossref] [PubMed]

Kim, S.

S. Cho, S. Kim, Y. Kim, and Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30, 71–79 (2012).
[Crossref]

Kim, S. H.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Kim, Y.

S. Cho, S. Kim, Y. Kim, and Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30, 71–79 (2012).
[Crossref]

Kinahan, P. E.

T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
[PubMed]

Klingel, K.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Klose, A. D.

A. D. Klose and E. W. Larsen, “Light transport in biological tissue based on the simplified spherical harmonics equations,” J. Comput. Phys. 220, 441–470 (2006).
[Crossref]

Kneilling, M.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Kogel, C.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
[Crossref] [PubMed]

Kolb, A.

B. J. Pichler, A. Kolb, T. Nägele, and H.-P. Schlemmer, “Pet/mri: paving the way for the next generation of clinical multimodality imaging applications,” J. Nucl. Med 51, 333–336 (2010).
[Crossref] [PubMed]

Kolehmainen, V.

T. Tarvainen, M. Vauhkonen, V. Kolehmainen, and J. Kaipio, “Finite element model for the coupled radiative transfer equation and diffusion approximation,” Int. J. Numerical Methods Engineering 65, 383–405 (2006).
[Crossref]

Konecky, S. D.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

Kumar, D.

Larsen, E. W.

A. D. Klose and E. W. Larsen, “Light transport in biological tissue based on the simplified spherical harmonics equations,” J. Comput. Phys. 220, 441–470 (2006).
[Crossref]

Leahy, R. M.

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, “Fast iterative image reconstruction methods for fully 3d multispectral bioluminescence tomography,” Phys. Med. Biol. 53, 3921 (2008).
[Crossref] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging,” Phys. Med. Biol. 50, 5421 (2005).
[Crossref] [PubMed]

Lee, J. H.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Lee, K.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

Leussler, C.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[Crossref]

Li, H.

Li, X.

Li, Y.

G. Wang, Y. Li, and M. Jiang, “Uniqueness theorems in bioluminescence tomography,” Med. Phys. 31, 2289 (2004).
[Crossref] [PubMed]

Liang, J.

Licha, K.

K. Licha and C. Olbrich, “Optical imaging in drug discovery and diagnostic applications,” Adv. Drug Delivery Rev. 57, 1087–1108 (2005).
[Crossref]

Lichy, M. P.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Lin, Y.

M. B. Unlu, Y. Lin, O. Birgul, O. Nalcioglu, and G. Gulsen, “Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging,” J. Biomed. Opt. 13, 060501 (2008).
[Crossref]

Liu, D.

Liu, F.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Liu, J.

Liu, K.

Liu, Y.

Lu, Y.

Luo, J.

Luscher, T. F.

O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
[Crossref] [PubMed]

Lv, Y.

Y. Lv, J. Tian, W. Cong, G. Wang, W. Yang, C. Qin, and M. Xu, “Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation,” Phys. Med. Biol. 52, 4497 (2007).
[Crossref] [PubMed]

Y. Lv, J. Tian, W. Cong, G. Wang, J. Luo, W. Yang, and H. Li, “A multilevel adaptive finite element algorithm for bioluminescence tomography,” Opt. Express 14, 8211–8223 (2006).
[Crossref] [PubMed]

Ma, X.

Machulla, H. J.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Maire, M.

P. Arbelaez, M. Maire, C. Fowlkes, and J. Malik, “Contour detection and hierarchical image segmentation,” IEEE Trans. Pattern Analysis and Machine Intelligence 33, 898–916 (2011).
[Crossref]

Malik, J.

P. Arbelaez, M. Maire, C. Fowlkes, and J. Malik, “Contour detection and hierarchical image segmentation,” IEEE Trans. Pattern Analysis and Machine Intelligence 33, 898–916 (2011).
[Crossref]

Mao, J.

Mazurkewitz, P.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[Crossref]

McBride, T. O.

McCray, P. B.

McLennan, G.

Moats, R. A.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging,” Phys. Med. Biol. 50, 5421 (2005).
[Crossref] [PubMed]

Moore, A.

E. M. Hillman and A. Moore, “All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast,” Nat. Photonics 1, 526–530 (2007).
[Crossref]

Nägele, T.

B. J. Pichler, A. Kolb, T. Nägele, and H.-P. Schlemmer, “Pet/mri: paving the way for the next generation of clinical multimodality imaging applications,” J. Nucl. Med 51, 333–336 (2010).
[Crossref] [PubMed]

Nalcioglu, O.

M. B. Unlu, Y. Lin, O. Birgul, O. Nalcioglu, and G. Gulsen, “Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging,” J. Biomed. Opt. 13, 060501 (2008).
[Crossref]

Naser, M. A.

Newport, D. F.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Ntziachristos, V.

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “Fmt-xct: in vivo animal studies with hybrid fluorescence molecular tomography-x-ray computed tomography,” Nat. Meth. 9, 615–620 (2012).
[Crossref]

R. B. Schulz, J. Ripoll, and V. Ntziachristos, “Experimental fluorescence tomography of tissues with noncontact measurements,” IEEE Trans. Med. Imaging 23, 492–500 (2004).
[Crossref] [PubMed]

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, “Fluorescence molecular tomography resolves protease activity in vivo,” Nat. Med. 8, 757–761 (2002).
[Crossref] [PubMed]

V. Ntziachristos, A. Yodh, M. Schnall, and B. Chance, “Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement,” Proc. Nat. Acad. Sci. USA 97, 2767–2772 (2000).
[Crossref] [PubMed]

Nutt, R.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
[PubMed]

Oei, Y.

D. E. Jenkins, Y. Oei, Y. S. Hornig, S.-F. Yu, J. Dusich, T. Purchio, and P. R. Contag, “Bioluminescent imaging (bli) to improve and refine traditional murine models of tumor growth and metastasis,” Clin. Exp. Metastasis 20, 733–744 (2003).
[Crossref]

Olbrich, C.

K. Licha and C. Olbrich, “Optical imaging in drug discovery and diagnostic applications,” Adv. Drug Delivery Rev. 57, 1087–1108 (2005).
[Crossref]

Österberg, U. L.

Park, G.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Park, Y.

S. Cho, S. Kim, Y. Kim, and Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30, 71–79 (2012).
[Crossref]

Patterson, M. S.

Paulsen, K. D.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[Crossref]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
[Crossref] [PubMed]

B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (nir) tomography breast image reconstruction with a priori structural information from mri: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9, 199–209 (2003).
[Crossref]

B. W. Pogue, S. Geimer, T. O. McBride, S. Jiang, U. L. Österberg, and K. D. Paulsen, “Three-dimensional simulation of near-infrared diffusion in tissue: boundary condition and geometry analysis for finite-element image reconstruction,” Appl. Opt. 40, 588–600 (2001).
[Crossref]

Pichler, B. J.

B. J. Pichler, A. Kolb, T. Nägele, and H.-P. Schlemmer, “Pet/mri: paving the way for the next generation of clinical multimodality imaging applications,” J. Nucl. Med 51, 333–336 (2010).
[Crossref] [PubMed]

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Pogue, B. W.

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer mri-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Nat. Acad. Sci. USA 110, 9025–9030 (2013).
[Crossref] [PubMed]

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[Crossref]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
[Crossref] [PubMed]

B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (nir) tomography breast image reconstruction with a priori structural information from mri: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9, 199–209 (2003).
[Crossref]

B. W. Pogue, S. Geimer, T. O. McBride, S. Jiang, U. L. Österberg, and K. D. Paulsen, “Three-dimensional simulation of near-infrared diffusion in tissue: boundary condition and geometry analysis for finite-element image reconstruction,” Appl. Opt. 40, 588–600 (2001).
[Crossref]

Poplack, S. P.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
[Crossref] [PubMed]

Purchio, T.

D. E. Jenkins, Y. Oei, Y. S. Hornig, S.-F. Yu, J. Dusich, T. Purchio, and P. R. Contag, “Bioluminescent imaging (bli) to improve and refine traditional murine models of tumor growth and metastasis,” Clin. Exp. Metastasis 20, 733–744 (2003).
[Crossref]

Qian, X.

G. Wang, H. Shen, K. Durairaj, X. Qian, and W. Cong, “The first bioluminescence tomography system for simultaneous acquisition of multiview and multispectral data,” Int. J. Biomed. Imaging 2006, 58601 (2006).
[Crossref] [PubMed]

G. Wang, W. Cong, K. Durairaj, X. Qian, H. Shen, P. Sinn, E. Hoffman, G. McLennan, and M. Henry, “In vivo mouse studies with bioluminescence tomography,” Opt. Express 14, 7801–7809 (2006).
[Crossref] [PubMed]

Qin, C.

J. Feng, C. Qin, K. Jia, S. Zhu, X. Yang, and J. Tian, “Bioluminescence tomography imaging in vivo: recent advances,” IEEE J. Sel. Top. Quantum Electron. 18, 1394–1402 (2012).
[Crossref]

J. Zhong, J. Tian, X. Yang, and C. Qin, “Whole-body cerenkov luminescence tomography with the finite element sp3 method,” Ann. Biomed. Eng. 39, 1728–1735 (2011).
[Crossref] [PubMed]

J. Tian, K. Liu, Y. Lu, C. Qin, X. Yang, S. Zhu, D. Han, J. Feng, X. Ma, and Z. Chang, “Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models,” Opt. Express 18, 20988–21002 (2010).
[Crossref] [PubMed]

B. Zhang, X. Yang, C. Qin, D. Liu, S. Zhu, J. Feng, L. Sun, K. Liu, D. Han, X. Ma, and et al., “A trust region method in adaptive finite element framework for bioluminescence tomography,” Opt. Express 18, 6477–6491 (2010).
[Crossref] [PubMed]

Y. Lv, J. Tian, W. Cong, G. Wang, W. Yang, C. Qin, and M. Xu, “Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation,” Phys. Med. Biol. 52, 4497 (2007).
[Crossref] [PubMed]

Qu, X.

Rannou, F. R.

G. Alexandrakis, F. R. Rannou, and A. F. Chatziioannou, “Tomographic bioluminescence imaging by use of a combined optical-pet (opet) system: a computer simulation feasibility study,” Phys. Med. Biol. 50, 4225 (2005).
[Crossref] [PubMed]

Ratib, O.

O. Ratib and T. Beyer, “Whole-body hybrid pet/mri: ready for clinical use?” Eur. J. Nucl. Med. Mol. Imaging 38, 992–995 (2011).
[Crossref] [PubMed]

Reischl, G.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Ren, N.

Ren, S.

S. Ren, X. Chen, H. Wang, X. Qu, G. Wang, J. Liang, and J. Tian, “Molecular optical simulation environment (mose): A platform for the simulation of light propagation in turbid media,” PloS one 8, e61304 (2013).
[Crossref] [PubMed]

Ripoll, J.

F. Stuker, C. Baltes, K. Dikaiou, D. Vats, L. Carrara, E. Charbon, J. Ripoll, and M. Rudin, “Hybrid small animal imaging system combining magnetic resonance imaging with fluorescence tomography using single photon avalanche diode detectors,” IEEE Trans. Med. Imaging 30, 1265–1273 (2011).
[Crossref] [PubMed]

R. B. Schulz, J. Ripoll, and V. Ntziachristos, “Experimental fluorescence tomography of tissues with noncontact measurements,” IEEE Trans. Med. Imaging 23, 492–500 (2004).
[Crossref] [PubMed]

Rocken, M.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Roddy, R.

T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
[PubMed]

Rosen, M. A.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

Rudin, M.

F. Stuker, C. Baltes, K. Dikaiou, D. Vats, L. Carrara, E. Charbon, J. Ripoll, and M. Rudin, “Hybrid small animal imaging system combining magnetic resonance imaging with fluorescence tomography using single photon avalanche diode detectors,” IEEE Trans. Med. Imaging 30, 1265–1273 (2011).
[Crossref] [PubMed]

Samkoe, K. S.

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer mri-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Nat. Acad. Sci. USA 110, 9025–9030 (2013).
[Crossref] [PubMed]

Scheffel, H.

O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
[Crossref] [PubMed]

Schepis, T.

O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
[Crossref] [PubMed]

Schlemmer, H.-P.

B. J. Pichler, A. Kolb, T. Nägele, and H.-P. Schlemmer, “Pet/mri: paving the way for the next generation of clinical multimodality imaging applications,” J. Nucl. Med 51, 333–336 (2010).
[Crossref] [PubMed]

Schnall, M.

V. Ntziachristos, A. Yodh, M. Schnall, and B. Chance, “Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement,” Proc. Nat. Acad. Sci. USA 97, 2767–2772 (2000).
[Crossref] [PubMed]

Schulz, R. B.

R. B. Schulz, J. Ripoll, and V. Ntziachristos, “Experimental fluorescence tomography of tissues with noncontact measurements,” IEEE Trans. Med. Imaging 23, 492–500 (2004).
[Crossref] [PubMed]

Schweiger, M.

M. Schweiger, S. Arridge, M. Hiraoka, and D. Delpy, “The finite element method for the propagation of light in scattering media: boundary and source conditions,” Med. Phys. 22, 1779 (1995).
[Crossref] [PubMed]

S. Arridge, M. Schweiger, M. Hiraoka, and D. Delpy, “A finite element approach for modeling photon transport in tissue,” Med. Phys. 20, 299 (1993).
[Crossref] [PubMed]

Sexton, K. J.

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer mri-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Nat. Acad. Sci. USA 110, 9025–9030 (2013).
[Crossref] [PubMed]

Shen, H.

G. Wang, H. Shen, K. Durairaj, X. Qian, and W. Cong, “The first bioluminescence tomography system for simultaneous acquisition of multiview and multispectral data,” Int. J. Biomed. Imaging 2006, 58601 (2006).
[Crossref] [PubMed]

G. Wang, W. Cong, K. Durairaj, X. Qian, H. Shen, P. Sinn, E. Hoffman, G. McLennan, and M. Henry, “In vivo mouse studies with bioluminescence tomography,” Opt. Express 14, 7801–7809 (2006).
[Crossref] [PubMed]

Siegel, S. B.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Sinn, P.

Smith, D. J.

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging,” Phys. Med. Biol. 50, 5421 (2005).
[Crossref] [PubMed]

Springett, R.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[Crossref]

Srinivasan, S.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
[Crossref] [PubMed]

Stuker, F.

F. Stuker, C. Baltes, K. Dikaiou, D. Vats, L. Carrara, E. Charbon, J. Ripoll, and M. Rudin, “Hybrid small animal imaging system combining magnetic resonance imaging with fluorescence tomography using single photon avalanche diode detectors,” IEEE Trans. Med. Imaging 30, 1265–1273 (2011).
[Crossref] [PubMed]

Sun, D.

Sun, L.

Tarvainen, T.

T. Tarvainen, M. Vauhkonen, V. Kolehmainen, and J. Kaipio, “Finite element model for the coupled radiative transfer equation and diffusion approximation,” Int. J. Numerical Methods Engineering 65, 383–405 (2006).
[Crossref]

Thielscher, A.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Tian, J.

S. Ren, X. Chen, H. Wang, X. Qu, G. Wang, J. Liang, and J. Tian, “Molecular optical simulation environment (mose): A platform for the simulation of light propagation in turbid media,” PloS one 8, e61304 (2013).
[Crossref] [PubMed]

J. Feng, C. Qin, K. Jia, S. Zhu, X. Yang, and J. Tian, “Bioluminescence tomography imaging in vivo: recent advances,” IEEE J. Sel. Top. Quantum Electron. 18, 1394–1402 (2012).
[Crossref]

Q. Zhang, X. Chen, X. Qu, J. Liang, and J. Tian, “Comparative studies of lp-regularization-based reconstruction algorithms for bioluminescence tomography,” Biomed. Opt. Express 3, 2916–2936 (2012).
[Crossref] [PubMed]

J. Zhong, J. Tian, X. Yang, and C. Qin, “Whole-body cerenkov luminescence tomography with the finite element sp3 method,” Ann. Biomed. Eng. 39, 1728–1735 (2011).
[Crossref] [PubMed]

J. Tian, K. Liu, Y. Lu, C. Qin, X. Yang, S. Zhu, D. Han, J. Feng, X. Ma, and Z. Chang, “Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models,” Opt. Express 18, 20988–21002 (2010).
[Crossref] [PubMed]

R. Han, J. Liang, X. Qu, Y. Hou, N. Ren, J. Mao, and J. Tian, “A source reconstruction algorithm based on adaptive hp-fem for bioluminescence tomography,” Opt. Express 17, 14481–14494 (2009).
[Crossref] [PubMed]

Y. Lv, J. Tian, W. Cong, G. Wang, W. Yang, C. Qin, and M. Xu, “Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation,” Phys. Med. Biol. 52, 4497 (2007).
[Crossref] [PubMed]

Y. Lv, J. Tian, W. Cong, G. Wang, J. Luo, W. Yang, and H. Li, “A multilevel adaptive finite element algorithm for bioluminescence tomography,” Opt. Express 14, 8211–8223 (2006).
[Crossref] [PubMed]

Tichauer, K. M.

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer mri-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Nat. Acad. Sci. USA 110, 9025–9030 (2013).
[Crossref] [PubMed]

Tosteson, T. D.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
[Crossref] [PubMed]

Townsend, D. W.

T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
[PubMed]

Tung, C.-H.

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, “Fluorescence molecular tomography resolves protease activity in vivo,” Nat. Med. 8, 757–761 (2002).
[Crossref] [PubMed]

Tuttle, S. B.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[Crossref]

Uludag, K.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Unlu, M. B.

M. B. Unlu, Y. Lin, O. Birgul, O. Nalcioglu, and G. Gulsen, “Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging,” J. Biomed. Opt. 13, 060501 (2008).
[Crossref]

Valenta, I.

O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
[Crossref] [PubMed]

van Bruggen, N.

J. K. Willmann, N. van Bruggen, L. M. Dinkelborg, and S. S. Gambhir, “Molecular imaging in drug development,” Nat. Rev. Drug Discovery 7, 591–607 (2008).
[Crossref]

Van Gemert, M. J.

A. J. Welch and M. J. Van Gemert, Optical-Thermal Response of Laser-Irradiated Tissue (Springer, 2010).

Vats, D.

F. Stuker, C. Baltes, K. Dikaiou, D. Vats, L. Carrara, E. Charbon, J. Ripoll, and M. Rudin, “Hybrid small animal imaging system combining magnetic resonance imaging with fluorescence tomography using single photon avalanche diode detectors,” IEEE Trans. Med. Imaging 30, 1265–1273 (2011).
[Crossref] [PubMed]

Vauhkonen, M.

T. Tarvainen, M. Vauhkonen, V. Kolehmainen, and J. Kaipio, “Finite element model for the coupled radiative transfer equation and diffusion approximation,” Int. J. Numerical Methods Engineering 65, 383–405 (2006).
[Crossref]

Wang, G.

S. Ren, X. Chen, H. Wang, X. Qu, G. Wang, J. Liang, and J. Tian, “Molecular optical simulation environment (mose): A platform for the simulation of light propagation in turbid media,” PloS one 8, e61304 (2013).
[Crossref] [PubMed]

R. Gong, G. Wang, X. Cheng, and W. Han, “A novel approach for studies of multispectral bioluminescence tomography,” Numerische Mathematik 115, 553–583 (2010).
[Crossref]

Y. Lv, J. Tian, W. Cong, G. Wang, W. Yang, C. Qin, and M. Xu, “Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation,” Phys. Med. Biol. 52, 4497 (2007).
[Crossref] [PubMed]

G. Wang, W. Cong, K. Durairaj, X. Qian, H. Shen, P. Sinn, E. Hoffman, G. McLennan, and M. Henry, “In vivo mouse studies with bioluminescence tomography,” Opt. Express 14, 7801–7809 (2006).
[Crossref] [PubMed]

G. Wang, H. Shen, K. Durairaj, X. Qian, and W. Cong, “The first bioluminescence tomography system for simultaneous acquisition of multiview and multispectral data,” Int. J. Biomed. Imaging 2006, 58601 (2006).
[Crossref] [PubMed]

Y. Lv, J. Tian, W. Cong, G. Wang, J. Luo, W. Yang, and H. Li, “A multilevel adaptive finite element algorithm for bioluminescence tomography,” Opt. Express 14, 8211–8223 (2006).
[Crossref] [PubMed]

A. X. Cong and G. Wang, “Multispectral bioluminescence tomography: methodology and simulation,” Int. J. Biomed. Imaging 2006, 57614 (2006).
[Crossref] [PubMed]

W. Cong, G. Wang, D. Kumar, Y. Liu, M. Jiang, L. V. Wang, E. A. Hoffman, G. McLennan, P. B. McCray, J. Zabner, and et al., “Practical reconstruction method for bioluminescence tomography,” Opt. Express 13, 6756–6771 (2005).
[Crossref] [PubMed]

G. Wang, Y. Li, and M. Jiang, “Uniqueness theorems in bioluminescence tomography,” Med. Phys. 31, 2289 (2004).
[Crossref] [PubMed]

Wang, H.

S. Ren, X. Chen, H. Wang, X. Qu, G. Wang, J. Liang, and J. Tian, “Molecular optical simulation environment (mose): A platform for the simulation of light propagation in turbid media,” PloS one 8, e61304 (2013).
[Crossref] [PubMed]

Wang, L. V.

Wang, Y.

Weaver, J.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
[Crossref] [PubMed]

Wehrl, H. F.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Weissleder, R.

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, “Fluorescence molecular tomography resolves protease activity in vivo,” Nat. Med. 8, 757–761 (2002).
[Crossref] [PubMed]

Welch, A. J.

A. J. Welch and M. J. Van Gemert, Optical-Thermal Response of Laser-Irradiated Tissue (Springer, 2010).

Widmaier, S.

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

Willmann, J. K.

J. K. Willmann, N. van Bruggen, L. M. Dinkelborg, and S. S. Gambhir, “Molecular imaging in drug development,” Nat. Rev. Drug Discovery 7, 591–607 (2008).
[Crossref]

Xie, Y.

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Xu, M.

Y. Lv, J. Tian, W. Cong, G. Wang, W. Yang, C. Qin, and M. Xu, “Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation,” Phys. Med. Biol. 52, 4497 (2007).
[Crossref] [PubMed]

Yang, W.

Y. Lv, J. Tian, W. Cong, G. Wang, W. Yang, C. Qin, and M. Xu, “Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation,” Phys. Med. Biol. 52, 4497 (2007).
[Crossref] [PubMed]

Y. Lv, J. Tian, W. Cong, G. Wang, J. Luo, W. Yang, and H. Li, “A multilevel adaptive finite element algorithm for bioluminescence tomography,” Opt. Express 14, 8211–8223 (2006).
[Crossref] [PubMed]

Yang, X.

Yodh, A.

V. Ntziachristos, A. Yodh, M. Schnall, and B. Chance, “Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement,” Proc. Nat. Acad. Sci. USA 97, 2767–2772 (2000).
[Crossref] [PubMed]

Yodh, A. G.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

Young, J.

T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
[PubMed]

Yu, S.-F.

D. E. Jenkins, Y. Oei, Y. S. Hornig, S.-F. Yu, J. Dusich, T. Purchio, and P. R. Contag, “Bioluminescent imaging (bli) to improve and refine traditional murine models of tumor growth and metastasis,” Clin. Exp. Metastasis 20, 733–744 (2003).
[Crossref]

Zabner, J.

Zhang, B.

Zhang, Q.

Zhang, R.

Zhang, Y.

S. Jiang, M. K. Gnanasammandhan, and Y. Zhang, “Optical imaging-guided cancer therapy with fluorescent nanoparticles,” J. R. Soc., Interface 7, 3–18 (2010).
[Crossref]

Zhong, J.

J. Zhong, J. Tian, X. Yang, and C. Qin, “Whole-body cerenkov luminescence tomography with the finite element sp3 method,” Ann. Biomed. Eng. 39, 1728–1735 (2011).
[Crossref] [PubMed]

Zhu, S.

Adv. Drug Delivery Rev. (1)

K. Licha and C. Olbrich, “Optical imaging in drug discovery and diagnostic applications,” Adv. Drug Delivery Rev. 57, 1087–1108 (2005).
[Crossref]

Ann. Biomed. Eng. (1)

J. Zhong, J. Tian, X. Yang, and C. Qin, “Whole-body cerenkov luminescence tomography with the finite element sp3 method,” Ann. Biomed. Eng. 39, 1728–1735 (2011).
[Crossref] [PubMed]

Appl. Opt. (1)

Biomed. Opt. Express (2)

Clin. Exp. Metastasis (1)

D. E. Jenkins, Y. Oei, Y. S. Hornig, S.-F. Yu, J. Dusich, T. Purchio, and P. R. Contag, “Bioluminescent imaging (bli) to improve and refine traditional murine models of tumor growth and metastasis,” Clin. Exp. Metastasis 20, 733–744 (2003).
[Crossref]

Eur. J. Nucl. Med. Mol. Imaging (1)

O. Ratib and T. Beyer, “Whole-body hybrid pet/mri: ready for clinical use?” Eur. J. Nucl. Med. Mol. Imaging 38, 992–995 (2011).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (2)

B. A. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, “Near-infrared (nir) tomography breast image reconstruction with a priori structural information from mri: algorithm development for reconstructing heterogeneities,” IEEE J. Sel. Top. Quantum Electron. 9, 199–209 (2003).
[Crossref]

J. Feng, C. Qin, K. Jia, S. Zhu, X. Yang, and J. Tian, “Bioluminescence tomography imaging in vivo: recent advances,” IEEE J. Sel. Top. Quantum Electron. 18, 1394–1402 (2012).
[Crossref]

IEEE Trans. Med. Imaging (2)

R. B. Schulz, J. Ripoll, and V. Ntziachristos, “Experimental fluorescence tomography of tissues with noncontact measurements,” IEEE Trans. Med. Imaging 23, 492–500 (2004).
[Crossref] [PubMed]

F. Stuker, C. Baltes, K. Dikaiou, D. Vats, L. Carrara, E. Charbon, J. Ripoll, and M. Rudin, “Hybrid small animal imaging system combining magnetic resonance imaging with fluorescence tomography using single photon avalanche diode detectors,” IEEE Trans. Med. Imaging 30, 1265–1273 (2011).
[Crossref] [PubMed]

IEEE Trans. Pattern Analysis and Machine Intelligence (1)

P. Arbelaez, M. Maire, C. Fowlkes, and J. Malik, “Contour detection and hierarchical image segmentation,” IEEE Trans. Pattern Analysis and Machine Intelligence 33, 898–916 (2011).
[Crossref]

Int. J. Biomed. Imaging (2)

A. X. Cong and G. Wang, “Multispectral bioluminescence tomography: methodology and simulation,” Int. J. Biomed. Imaging 2006, 57614 (2006).
[Crossref] [PubMed]

G. Wang, H. Shen, K. Durairaj, X. Qian, and W. Cong, “The first bioluminescence tomography system for simultaneous acquisition of multiview and multispectral data,” Int. J. Biomed. Imaging 2006, 58601 (2006).
[Crossref] [PubMed]

Int. J. Numerical Methods Engineering (1)

T. Tarvainen, M. Vauhkonen, V. Kolehmainen, and J. Kaipio, “Finite element model for the coupled radiative transfer equation and diffusion approximation,” Int. J. Numerical Methods Engineering 65, 383–405 (2006).
[Crossref]

Inverse Probl. (1)

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41 (1999).
[Crossref]

J. Biomed. Opt. (2)

M. Allard, D. Côté, L. Davidson, J. Dazai, and R. M. Henkelman, “Combined magnetic resonance and bioluminescence imaging of live mice,” J. Biomed. Opt. 12, 034018 (2007).
[Crossref] [PubMed]

M. B. Unlu, Y. Lin, O. Birgul, O. Nalcioglu, and G. Gulsen, “Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging,” J. Biomed. Opt. 13, 060501 (2008).
[Crossref]

J. Comput. Phys. (1)

A. D. Klose and E. W. Larsen, “Light transport in biological tissue based on the simplified spherical harmonics equations,” J. Comput. Phys. 220, 441–470 (2006).
[Crossref]

J. Electron. Imaging (1)

G. S. Abdoulaev and A. H. Hielscher, “Three-dimensional optical tomography with the equation of radiative transfer,” J. Electron. Imaging 12, 594–601 (2003).
[Crossref]

J. Nucl. Med (1)

B. J. Pichler, A. Kolb, T. Nägele, and H.-P. Schlemmer, “Pet/mri: paving the way for the next generation of clinical multimodality imaging applications,” J. Nucl. Med 51, 333–336 (2010).
[Crossref] [PubMed]

J. Nucl. Med. (2)

T. Beyer, D. W. Townsend, T. Brun, P. E. Kinahan, M. Charron, R. Roddy, J. Jerin, J. Young, L. Byars, R. Nutt, and et al., “A combined pet/ct scanner for clinical oncology,” J. Nucl. Med. 41, 1369–1379 (2000).
[PubMed]

O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann, “Cardiac image fusion from stand-alone spect and ct: clinical experience,” J. Nucl. Med. 48, 696–703 (2007).
[Crossref] [PubMed]

J. R. Soc., Interface (1)

S. Jiang, M. K. Gnanasammandhan, and Y. Zhang, “Optical imaging-guided cancer therapy with fluorescent nanoparticles,” J. R. Soc., Interface 7, 3–18 (2010).
[Crossref]

Med. Phys. (4)

S. Arridge, M. Schweiger, M. Hiraoka, and D. Delpy, “A finite element approach for modeling photon transport in tissue,” Med. Phys. 20, 299 (1993).
[Crossref] [PubMed]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to mri,” Med. Phys. 32, 1128 (2005).
[Crossref] [PubMed]

M. Schweiger, S. Arridge, M. Hiraoka, and D. Delpy, “The finite element method for the propagation of light in scattering media: boundary and source conditions,” Med. Phys. 22, 1779 (1995).
[Crossref] [PubMed]

G. Wang, Y. Li, and M. Jiang, “Uniqueness theorems in bioluminescence tomography,” Med. Phys. 31, 2289 (2004).
[Crossref] [PubMed]

Nat. Biotechnol. (1)

H. S. Choi, S. L. Gibbs, J. H. Lee, S. H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary, and J. V. Frangioni, “Targeted zwitterionic near-infrared fluorophores for improved optical imaging,” Nat. Biotechnol. 31, 148–153 (2013).
[Crossref] [PubMed]

Nat. Med. (2)

M. S. Judenhofer, H. F. Wehrl, D. F. Newport, C. Catana, S. B. Siegel, M. Becker, A. Thielscher, M. Kneilling, M. P. Lichy, M. Eichner, K. Klingel, G. Reischl, S. Widmaier, M. Rocken, R. Nutt, H. J. Machulla, K. Uludag, S. R. Cherry, C. D. Claussen, and B. J. Pichler, “Simultaneous pet-mri: a new approach for functional and morphological imaging,” Nat. Med. 14, 459–465 (2008).
[Crossref] [PubMed]

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, “Fluorescence molecular tomography resolves protease activity in vivo,” Nat. Med. 8, 757–761 (2002).
[Crossref] [PubMed]

Nat. Meth. (1)

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “Fmt-xct: in vivo animal studies with hybrid fluorescence molecular tomography-x-ray computed tomography,” Nat. Meth. 9, 615–620 (2012).
[Crossref]

Nat. Photonics (1)

E. M. Hillman and A. Moore, “All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast,” Nat. Photonics 1, 526–530 (2007).
[Crossref]

Nat. Rev. Cancer (1)

K. Brindle, “New approaches for imaging tumour responses to treatment,” Nat. Rev. Cancer 8, 94–107 (2008).
[Crossref] [PubMed]

Nat. Rev. Drug Discovery (1)

J. K. Willmann, N. van Bruggen, L. M. Dinkelborg, and S. S. Gambhir, “Molecular imaging in drug development,” Nat. Rev. Drug Discovery 7, 591–607 (2008).
[Crossref]

Nature (1)

M. Baker, “Whole-animal imaging: The whole picture,” Nature 463, 977–980 (2010).
[Crossref] [PubMed]

Numerische Mathematik (1)

R. Gong, G. Wang, X. Cheng, and W. Han, “A novel approach for studies of multispectral bioluminescence tomography,” Numerische Mathematik 115, 553–583 (2010).
[Crossref]

Opt. Express (7)

W. Cong, G. Wang, D. Kumar, Y. Liu, M. Jiang, L. V. Wang, E. A. Hoffman, G. McLennan, P. B. McCray, J. Zabner, and et al., “Practical reconstruction method for bioluminescence tomography,” Opt. Express 13, 6756–6771 (2005).
[Crossref] [PubMed]

J. Liu, Y. Wang, X. Qu, X. Li, X. Ma, R. Han, Z. Hu, X. Chen, D. Sun, R. Zhang, and et al., “In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models,” Opt. Express 18, 13102 (2010).
[Crossref] [PubMed]

J. Tian, K. Liu, Y. Lu, C. Qin, X. Yang, S. Zhu, D. Han, J. Feng, X. Ma, and Z. Chang, “Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models,” Opt. Express 18, 20988–21002 (2010).
[Crossref] [PubMed]

G. Wang, W. Cong, K. Durairaj, X. Qian, H. Shen, P. Sinn, E. Hoffman, G. McLennan, and M. Henry, “In vivo mouse studies with bioluminescence tomography,” Opt. Express 14, 7801–7809 (2006).
[Crossref] [PubMed]

Y. Lv, J. Tian, W. Cong, G. Wang, J. Luo, W. Yang, and H. Li, “A multilevel adaptive finite element algorithm for bioluminescence tomography,” Opt. Express 14, 8211–8223 (2006).
[Crossref] [PubMed]

R. Han, J. Liang, X. Qu, Y. Hou, N. Ren, J. Mao, and J. Tian, “A source reconstruction algorithm based on adaptive hp-fem for bioluminescence tomography,” Opt. Express 17, 14481–14494 (2009).
[Crossref] [PubMed]

B. Zhang, X. Yang, C. Qin, D. Liu, S. Zhu, J. Feng, L. Sun, K. Liu, D. Han, X. Ma, and et al., “A trust region method in adaptive finite element framework for bioluminescence tomography,” Opt. Express 18, 6477–6491 (2010).
[Crossref] [PubMed]

Phys. Med. Biol. (4)

S. Ahn, A. J. Chaudhari, F. Darvas, C. A. Bouman, and R. M. Leahy, “Fast iterative image reconstruction methods for fully 3d multispectral bioluminescence tomography,” Phys. Med. Biol. 53, 3921 (2008).
[Crossref] [PubMed]

G. Alexandrakis, F. R. Rannou, and A. F. Chatziioannou, “Tomographic bioluminescence imaging by use of a combined optical-pet (opet) system: a computer simulation feasibility study,” Phys. Med. Biol. 50, 4225 (2005).
[Crossref] [PubMed]

Y. Lv, J. Tian, W. Cong, G. Wang, W. Yang, C. Qin, and M. Xu, “Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation,” Phys. Med. Biol. 52, 4497 (2007).
[Crossref] [PubMed]

A. J. Chaudhari, F. Darvas, J. R. Bading, R. A. Moats, P. S. Conti, D. J. Smith, S. R. Cherry, and R. M. Leahy, “Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging,” Phys. Med. Biol. 50, 5421 (2005).
[Crossref] [PubMed]

PloS one (1)

S. Ren, X. Chen, H. Wang, X. Qu, G. Wang, J. Liang, and J. Tian, “Molecular optical simulation environment (mose): A platform for the simulation of light propagation in turbid media,” PloS one 8, e61304 (2013).
[Crossref] [PubMed]

Proc. Nat. Acad. Sci. USA (3)

S. C. Davis, K. S. Samkoe, K. M. Tichauer, K. J. Sexton, J. R. Gunn, S. J. Deharvengt, T. Hasan, and B. W. Pogue, “Dynamic dual-tracer mri-guided fluorescence tomography to quantify receptor density in vivo,” Proc. Nat. Acad. Sci. USA 110, 9025–9030 (2013).
[Crossref] [PubMed]

V. Ntziachristos, A. Yodh, M. Schnall, and B. Chance, “Concurrent mri and diffuse optical tomography of breast after indocyanine green enhancement,” Proc. Nat. Acad. Sci. USA 97, 2767–2772 (2000).
[Crossref] [PubMed]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, “Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid mri-guided near-infrared spectral tomography,” Proc. Nat. Acad. Sci. USA 103, 8828–8833 (2006).
[Crossref] [PubMed]

Rev. Sci. Instrum. (1)

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance–coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79, 064302 (2008).
[Crossref]

Trends Biotechnol. (1)

S. Cho, S. Kim, Y. Kim, and Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30, 71–79 (2012).
[Crossref]

Other (3)

S. R. Cherry, “Multimodality imaging: Beyond pet/ct and spect/ct,” in Seminars in Nuclear Medicine,, vol. 39 (Elsevier, 2009), vol. 39, pp. 348–353.
[Crossref]

J. J. Duderstadt and L. J. Hamilton, “Nuclear reactor analysis,” (1976).

A. J. Welch and M. J. Van Gemert, Optical-Thermal Response of Laser-Irradiated Tissue (Springer, 2010).

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (11)

Fig. 1
Fig. 1

Magnetic field distribution (offered by GE Healthcare, China).

Fig. 2
Fig. 2

Integrated BLT and MRI system. (a) Placement of the optical and MRI devices. (b) Animal holder. (c) Small animal coil of MRI.

Fig. 3
Fig. 3

Structure inside the light tight chamber of the optical device.

Fig. 4
Fig. 4

Heterogeneous cylindrical phantom with different ellipsoidal organs.

Fig. 5
Fig. 5

Surface data from different view angles.

Fig. 6
Fig. 6

Reconstruction results at different view angles. Regions in green are the true light sources. Regions in red are the reconstructed light sources.

Fig. 7
Fig. 7

Overlay images of photographs and bioluminescence images.

Fig. 8
Fig. 8

Reconstructions of artificial light source. The green regions are the real light sources, the red regions are the reconstructed sources

Fig. 9
Fig. 9

Relationship between the total power and tumor cell, x-axis is the number of cells and y-axis is the power measured by intensity value. (a) is the result of in vitro experiment, (b) is the result of BLI and (c) is the result of BLT.

Fig. 10
Fig. 10

Overlay images of photographs and bioluminescence images.

Fig. 11
Fig. 11

Reconstructions of nude mice with tumors. The red regions are the reconstruction sources.

Tables (5)

Tables Icon

Table 1 Optical parameters (mm−1) for regions of the phantom

Tables Icon

Table 2 Benchmarks for the reconstructions at different view angles

Tables Icon

Table 3 Optical parameters (mm−1) for in vivo experiment

Tables Icon

Table 4 Benchmarks for the reconstruction of the implanted mouse models

Tables Icon

Table 5 The benchmarks for the reconstructions of tumor inoculation models

Equations (13)

Equations on this page are rendered with MathJax. Learn more.

( D λ ( x ) Φ λ ( x ) ) + μ λ α ( x ) Φ λ ( x ) = S λ ( x ) ( x Ω ) ,
Φ λ ( x ) + 2 A ( x ; n , n ) D λ ( x ) ( v ( x ) Φ λ ( x ) ) = 0 ( x Ω ) ,
Q λ ( x ) = D λ ( x ) ( v ( x ) Φ λ ( x ) ) = Φ λ ( x ) 2 A ( x ; n , n ) ( x Ω ) .
M λ Φ λ = F λ S λ ,
Φ λ = M λ 1 F λ S λ .
A λ S λ p = Φ λ meas ,
AS t = Φ meas ,
A [ ω λ 1 A λ 1 ω λ 2 A λ 2 ω λ n A λ N ] ,
Φ meas [ Φ λ 1 meas Φ λ 2 meas Φ λ N meas ] ,
min 0 S λ i p S sup t { AS t Φ meas 2 2 + α S t 1 } ,
𝒫 = ( x r x 0 ) 2 + ( y r y 0 ) 2 + ( z r z 0 ) 2 ,
= | S r S 0 | S 0 ,
𝒪 = | R r R 0 | | R r R 0 | .

Metrics