Abstract

Combining Fluorescent Molecular Tomography (FMT) with anatomical imaging, e.g. MRI facilitates interpreting functional information. Furthermore, using a heterogeneous model for light propagation has been shown in simulations to be superior to homogeneous modeling to quantify fluorescence. Here, we present a combined FMT-MRI system and apply it to heart and aorta molecular imaging, a challenging area due to strong tissue heterogeneity and the presence of air-voids due to lungs. First investigating performance in a phantom and mouse corpse, the MRI-enabled heterogeneous models resulted in an improved quantification of fluorescence reconstructions. The system was then used in mice for in vivo atherosclerosis molecular imaging. Results show that, when using the heterogeneous model, reconstructions were in agreement with the ex vivo measurements. Therefore, the proposed system might serve as a powerful imaging tool for atherosclerosis in mice.

© 2014 Optical Society of America

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References

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    [Crossref] [PubMed]
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2013 (2)

B. P. Flynn, A. V. DSouza, S. C. Kanick, S. C. Davis, and B. W. Pogue, “White light-informed optical properties improve ultrasound-guided fluorescence tomography of photoactive protoporphyrin IX,” J. Biomed. Opt. 18(4), 046008 (2013).
[Crossref] [PubMed]

A. Ale, V. Ermolayev, N. C. Deliolanis, and V. Ntziachristos, “Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer,” J. Biomed. Opt. 18(5), 056006 (2013).
[Crossref] [PubMed]

2012 (3)

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography,” Nat. Methods 9(6), 615–620 (2012).
[Crossref] [PubMed]

K. Radrich, A. Ale, V. Ermolayev, and V. Ntziachristos, “Improving limited-projection-angle fluorescence molecular tomography using a co-registered x-ray computed tomography scan,” J. Biomed. Opt. 17(12), 126011 (2012).
[Crossref] [PubMed]

J. F. P.-J. Abascal, J. Aguirre, J. Chamorro-Servent, M. Schweiger, S. Arridge, J. Ripoll, J. J. Vaquero, and M. Desco, “Influence of absorption and scattering on the quantification of fluorescence diffuse optical tomography using normalized data,” J. Biomed. Opt. 17(3), 036013 (2012).
[Crossref] [PubMed]

2011 (6)

B. Li, M. Abran, C. Matteau-Pelletier, L. Rouleau, T. Lam, R. Sharma, E. Rhéaume, A. Kakkar, J.-C. Tardif, and F. Lesage, “Low-cost three-dimensional imaging system combining fluorescence and ultrasound,” J. Biomed. Opt. 16(12), 126010 (2011).
[Crossref] [PubMed]

T. Pyka, R. Schulz, A. Ale, and V. Ntziachristos, “Revisiting the normalized Born approximation: effects of scattering,” Opt. Lett. 36(22), 4329–4331 (2011).
[Crossref] [PubMed]

A. Laidevant, L. Hervé, M. Debourdeau, J. Boutet, N. Grenier, and J.-M. Dinten, “Fluorescence time-resolved imaging system embedded in an ultrasound prostate probe,” Biomed. Opt. Express 2(1), 194–206 (2011).
[Crossref] [PubMed]

J.-C. Tardif, F. Lesage, F. Harel, P. Romeo, and J. Pressacco, “Imaging biomarkers in atherosclerosis trials,” Circ Cardiovasc Imaging 4(3), 319–333 (2011).
[Crossref] [PubMed]

Y. Lin, M. T. Ghijsen, H. Gao, N. Liu, O. Nalcioglu, and G. Gulsen, “A photo-multiplier tube-based hybrid MRI and frequency domain fluorescence tomography system for small animal imaging,” Phys. Med. Biol. 56(15), 4731–4747 (2011).
[Crossref] [PubMed]

F. Leblond, K. M. Tichauer, R. W. Holt, F. El-Ghussein, and B. W. Pogue, “Toward whole-body optical imaging of rats using single-photon counting fluorescence tomography,” Opt. Lett. 36(19), 3723–3725 (2011).
[Crossref] [PubMed]

2010 (3)

C. M. Carpenter, R. Rakow-Penner, S. Jiang, B. L. Daniel, B. W. Pogue, G. H. Glover, and K. D. Paulsen, “Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study,” J. Biomed. Opt. 15(3), 036026 (2010).
[Crossref] [PubMed]

Y. Lin, W. C. Barber, J. S. Iwanczyk, W. W. Roeck, O. Nalcioglu, and G. Gulsen, “Quantitative fluorescence tomography using a trimodality system: in vivo validation,” J. Biomed. Opt. 15(4), 040503 (2010).
[Crossref] [PubMed]

A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, “Imaging performance of a hybrid x-ray computed tomography-fluorescence molecular tomography system using priors,” Med. Phys. 37(5), 1976–1986 (2010).
[Crossref] [PubMed]

2009 (3)

F. A. Jaffer, P. Libby, and R. Weissleder, “Optical and multimodality molecular imaging: insights into atherosclerosis,” Arterioscler. Thromb. Vasc. Biol. 29(7), 1017–1024 (2009).
[Crossref] [PubMed]

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J. M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt. 14(6), 064001 (2009).
[Crossref] [PubMed]

Q. Fang and D. A. Boas, “Monte Carlo simulation of photon migration in 3D turbid media accelerated by graphics processing units,” Opt. Express 17(22), 20178–20190 (2009).
[Crossref] [PubMed]

2008 (2)

J. Sanz and Z. A. Fayad, “Imaging of atherosclerotic cardiovascular disease,” Nature 451(7181), 953–957 (2008).
[Crossref] [PubMed]

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008).
[Crossref] [PubMed]

2007 (3)

D. E. Sosnovik, M. Nahrendorf, N. Deliolanis, M. Novikov, E. Aikawa, L. Josephson, A. Rosenzweig, R. Weissleder, and V. Ntziachristos, “Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo,” Circulation 115(11), 1384–1391 (2007).
[Crossref] [PubMed]

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15(7), 4066–4082 (2007).
[Crossref] [PubMed]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, and K. D. Paulsen, “Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography,” Med. Phys. 34(6), 2085–2098 (2007).
[Crossref] [PubMed]

2006 (1)

V. S. Talanov, C. A. S. Regino, H. Kobayashi, M. Bernardo, P. L. Choyke, and M. W. Brechbiel, “Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging,” Nano Lett. 6(7), 1459–1463 (2006).
[Crossref] [PubMed]

2005 (2)

G. Alexandrakis, F. R. Rannou, and A. F. Chatziioannou, “Tomographic bioluminescence imaging by use of a combined optical-PET (OPET) system: a computer simulation feasibility study,” Phys. Med. Biol. 50(17), 4225–4241 (2005).
[Crossref] [PubMed]

A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
[Crossref] [PubMed]

2002 (1)

2001 (1)

1998 (1)

D. A. Sanan, D. L. Newland, R. Tao, S. Marcovina, J. Wang, V. Mooser, R. E. Hammer, and H. H. Hobbs, “Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a),” Proc. Natl. Acad. Sci. U.S.A. 95(8), 4544–4549 (1998).
[Crossref] [PubMed]

1993 (1)

P. C. Hansen and D. P. O’Leary, “The use of the L-curve in the regularization of discrete ill-posed problems,” SIAM J. Sci. Comput. 14(6), 1487–1503 (1993).
[Crossref]

Abascal, J. F. P.-J.

J. F. P.-J. Abascal, J. Aguirre, J. Chamorro-Servent, M. Schweiger, S. Arridge, J. Ripoll, J. J. Vaquero, and M. Desco, “Influence of absorption and scattering on the quantification of fluorescence diffuse optical tomography using normalized data,” J. Biomed. Opt. 17(3), 036013 (2012).
[Crossref] [PubMed]

Abran, M.

B. Li, M. Abran, C. Matteau-Pelletier, L. Rouleau, T. Lam, R. Sharma, E. Rhéaume, A. Kakkar, J.-C. Tardif, and F. Lesage, “Low-cost three-dimensional imaging system combining fluorescence and ultrasound,” J. Biomed. Opt. 16(12), 126010 (2011).
[Crossref] [PubMed]

Aguirre, J.

J. F. P.-J. Abascal, J. Aguirre, J. Chamorro-Servent, M. Schweiger, S. Arridge, J. Ripoll, J. J. Vaquero, and M. Desco, “Influence of absorption and scattering on the quantification of fluorescence diffuse optical tomography using normalized data,” J. Biomed. Opt. 17(3), 036013 (2012).
[Crossref] [PubMed]

Aikawa, E.

D. E. Sosnovik, M. Nahrendorf, N. Deliolanis, M. Novikov, E. Aikawa, L. Josephson, A. Rosenzweig, R. Weissleder, and V. Ntziachristos, “Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo,” Circulation 115(11), 1384–1391 (2007).
[Crossref] [PubMed]

Ale, A.

A. Ale, V. Ermolayev, N. C. Deliolanis, and V. Ntziachristos, “Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer,” J. Biomed. Opt. 18(5), 056006 (2013).
[Crossref] [PubMed]

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography,” Nat. Methods 9(6), 615–620 (2012).
[Crossref] [PubMed]

K. Radrich, A. Ale, V. Ermolayev, and V. Ntziachristos, “Improving limited-projection-angle fluorescence molecular tomography using a co-registered x-ray computed tomography scan,” J. Biomed. Opt. 17(12), 126011 (2012).
[Crossref] [PubMed]

T. Pyka, R. Schulz, A. Ale, and V. Ntziachristos, “Revisiting the normalized Born approximation: effects of scattering,” Opt. Lett. 36(22), 4329–4331 (2011).
[Crossref] [PubMed]

A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, “Imaging performance of a hybrid x-ray computed tomography-fluorescence molecular tomography system using priors,” Med. Phys. 37(5), 1976–1986 (2010).
[Crossref] [PubMed]

Alexandrakis, G.

G. Alexandrakis, F. R. Rannou, and A. F. Chatziioannou, “Tomographic bioluminescence imaging by use of a combined optical-PET (OPET) system: a computer simulation feasibility study,” Phys. Med. Biol. 50(17), 4225–4241 (2005).
[Crossref] [PubMed]

Arridge, S.

J. F. P.-J. Abascal, J. Aguirre, J. Chamorro-Servent, M. Schweiger, S. Arridge, J. Ripoll, J. J. Vaquero, and M. Desco, “Influence of absorption and scattering on the quantification of fluorescence diffuse optical tomography using normalized data,” J. Biomed. Opt. 17(3), 036013 (2012).
[Crossref] [PubMed]

Arridge, S. R.

A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
[Crossref] [PubMed]

Bae, E.

J. Yuan, E. Bae, and X.-C. Tai, “A study on continuous max-flow and min-cut approaches,” in 2010 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), 2217–2224 (2010).
[Crossref]

Barber, W. C.

Y. Lin, W. C. Barber, J. S. Iwanczyk, W. W. Roeck, O. Nalcioglu, and G. Gulsen, “Quantitative fluorescence tomography using a trimodality system: in vivo validation,” J. Biomed. Opt. 15(4), 040503 (2010).
[Crossref] [PubMed]

Bernardo, M.

V. S. Talanov, C. A. S. Regino, H. Kobayashi, M. Bernardo, P. L. Choyke, and M. W. Brechbiel, “Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging,” Nano Lett. 6(7), 1459–1463 (2006).
[Crossref] [PubMed]

Boas, D. A.

Boutet, J.

A. Laidevant, L. Hervé, M. Debourdeau, J. Boutet, N. Grenier, and J.-M. Dinten, “Fluorescence time-resolved imaging system embedded in an ultrasound prostate probe,” Biomed. Opt. Express 2(1), 194–206 (2011).
[Crossref] [PubMed]

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J. M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt. 14(6), 064001 (2009).
[Crossref] [PubMed]

Brechbiel, M. W.

V. S. Talanov, C. A. S. Regino, H. Kobayashi, M. Bernardo, P. L. Choyke, and M. W. Brechbiel, “Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging,” Nano Lett. 6(7), 1459–1463 (2006).
[Crossref] [PubMed]

Carpenter, C. M.

C. M. Carpenter, R. Rakow-Penner, S. Jiang, B. L. Daniel, B. W. Pogue, G. H. Glover, and K. D. Paulsen, “Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study,” J. Biomed. Opt. 15(3), 036026 (2010).
[Crossref] [PubMed]

Chamorro-Servent, J.

J. F. P.-J. Abascal, J. Aguirre, J. Chamorro-Servent, M. Schweiger, S. Arridge, J. Ripoll, J. J. Vaquero, and M. Desco, “Influence of absorption and scattering on the quantification of fluorescence diffuse optical tomography using normalized data,” J. Biomed. Opt. 17(3), 036013 (2012).
[Crossref] [PubMed]

Chatziioannou, A. F.

G. Alexandrakis, F. R. Rannou, and A. F. Chatziioannou, “Tomographic bioluminescence imaging by use of a combined optical-PET (OPET) system: a computer simulation feasibility study,” Phys. Med. Biol. 50(17), 4225–4241 (2005).
[Crossref] [PubMed]

Choyke, P. L.

V. S. Talanov, C. A. S. Regino, H. Kobayashi, M. Bernardo, P. L. Choyke, and M. W. Brechbiel, “Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging,” Nano Lett. 6(7), 1459–1463 (2006).
[Crossref] [PubMed]

Cohrs, C.

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography,” Nat. Methods 9(6), 615–620 (2012).
[Crossref] [PubMed]

Daniel, B. L.

C. M. Carpenter, R. Rakow-Penner, S. Jiang, B. L. Daniel, B. W. Pogue, G. H. Glover, and K. D. Paulsen, “Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study,” J. Biomed. Opt. 15(3), 036026 (2010).
[Crossref] [PubMed]

Davis, S. C.

B. P. Flynn, A. V. DSouza, S. C. Kanick, S. C. Davis, and B. W. Pogue, “White light-informed optical properties improve ultrasound-guided fluorescence tomography of photoactive protoporphyrin IX,” J. Biomed. Opt. 18(4), 046008 (2013).
[Crossref] [PubMed]

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008).
[Crossref] [PubMed]

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15(7), 4066–4082 (2007).
[Crossref] [PubMed]

de Angelis, M. H.

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography,” Nat. Methods 9(6), 615–620 (2012).
[Crossref] [PubMed]

Debourdeau, M.

A. Laidevant, L. Hervé, M. Debourdeau, J. Boutet, N. Grenier, and J.-M. Dinten, “Fluorescence time-resolved imaging system embedded in an ultrasound prostate probe,” Biomed. Opt. Express 2(1), 194–206 (2011).
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S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008).
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S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15(7), 4066–4082 (2007).
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P. K. Yalavarthy, B. W. Pogue, H. Dehghani, and K. D. Paulsen, “Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography,” Med. Phys. 34(6), 2085–2098 (2007).
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D. E. Sosnovik, M. Nahrendorf, N. Deliolanis, M. Novikov, E. Aikawa, L. Josephson, A. Rosenzweig, R. Weissleder, and V. Ntziachristos, “Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo,” Circulation 115(11), 1384–1391 (2007).
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A. Ale, V. Ermolayev, N. C. Deliolanis, and V. Ntziachristos, “Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer,” J. Biomed. Opt. 18(5), 056006 (2013).
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DSouza, A. V.

B. P. Flynn, A. V. DSouza, S. C. Kanick, S. C. Davis, and B. W. Pogue, “White light-informed optical properties improve ultrasound-guided fluorescence tomography of photoactive protoporphyrin IX,” J. Biomed. Opt. 18(4), 046008 (2013).
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J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J. M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt. 14(6), 064001 (2009).
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Ermolayev, V.

A. Ale, V. Ermolayev, N. C. Deliolanis, and V. Ntziachristos, “Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer,” J. Biomed. Opt. 18(5), 056006 (2013).
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A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography,” Nat. Methods 9(6), 615–620 (2012).
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K. Radrich, A. Ale, V. Ermolayev, and V. Ntziachristos, “Improving limited-projection-angle fluorescence molecular tomography using a co-registered x-ray computed tomography scan,” J. Biomed. Opt. 17(12), 126011 (2012).
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B. P. Flynn, A. V. DSouza, S. C. Kanick, S. C. Davis, and B. W. Pogue, “White light-informed optical properties improve ultrasound-guided fluorescence tomography of photoactive protoporphyrin IX,” J. Biomed. Opt. 18(4), 046008 (2013).
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Gao, F.

Gao, H.

Y. Lin, M. T. Ghijsen, H. Gao, N. Liu, O. Nalcioglu, and G. Gulsen, “A photo-multiplier tube-based hybrid MRI and frequency domain fluorescence tomography system for small animal imaging,” Phys. Med. Biol. 56(15), 4731–4747 (2011).
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Y. Lin, M. T. Ghijsen, H. Gao, N. Liu, O. Nalcioglu, and G. Gulsen, “A photo-multiplier tube-based hybrid MRI and frequency domain fluorescence tomography system for small animal imaging,” Phys. Med. Biol. 56(15), 4731–4747 (2011).
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S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008).
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A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
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C. M. Carpenter, R. Rakow-Penner, S. Jiang, B. L. Daniel, B. W. Pogue, G. H. Glover, and K. D. Paulsen, “Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study,” J. Biomed. Opt. 15(3), 036026 (2010).
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Gulsen, G.

Y. Lin, M. T. Ghijsen, H. Gao, N. Liu, O. Nalcioglu, and G. Gulsen, “A photo-multiplier tube-based hybrid MRI and frequency domain fluorescence tomography system for small animal imaging,” Phys. Med. Biol. 56(15), 4731–4747 (2011).
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J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J. M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt. 14(6), 064001 (2009).
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D. A. Sanan, D. L. Newland, R. Tao, S. Marcovina, J. Wang, V. Mooser, R. E. Hammer, and H. H. Hobbs, “Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a),” Proc. Natl. Acad. Sci. U.S.A. 95(8), 4544–4549 (1998).
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P. C. Hansen and D. P. O’Leary, “The use of the L-curve in the regularization of discrete ill-posed problems,” SIAM J. Sci. Comput. 14(6), 1487–1503 (1993).
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J.-C. Tardif, F. Lesage, F. Harel, P. Romeo, and J. Pressacco, “Imaging biomarkers in atherosclerosis trials,” Circ Cardiovasc Imaging 4(3), 319–333 (2011).
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A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
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J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J. M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt. 14(6), 064001 (2009).
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Hervé, L.

Herzog, E.

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography,” Nat. Methods 9(6), 615–620 (2012).
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Hobbs, H. H.

D. A. Sanan, D. L. Newland, R. Tao, S. Marcovina, J. Wang, V. Mooser, R. E. Hammer, and H. H. Hobbs, “Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a),” Proc. Natl. Acad. Sci. U.S.A. 95(8), 4544–4549 (1998).
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Holt, R. W.

Iwanczyk, J. S.

Y. Lin, W. C. Barber, J. S. Iwanczyk, W. W. Roeck, O. Nalcioglu, and G. Gulsen, “Quantitative fluorescence tomography using a trimodality system: in vivo validation,” J. Biomed. Opt. 15(4), 040503 (2010).
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F. A. Jaffer, P. Libby, and R. Weissleder, “Optical and multimodality molecular imaging: insights into atherosclerosis,” Arterioscler. Thromb. Vasc. Biol. 29(7), 1017–1024 (2009).
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Jiang, S.

C. M. Carpenter, R. Rakow-Penner, S. Jiang, B. L. Daniel, B. W. Pogue, G. H. Glover, and K. D. Paulsen, “Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study,” J. Biomed. Opt. 15(3), 036026 (2010).
[Crossref] [PubMed]

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15(7), 4066–4082 (2007).
[Crossref] [PubMed]

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S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008).
[Crossref] [PubMed]

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D. E. Sosnovik, M. Nahrendorf, N. Deliolanis, M. Novikov, E. Aikawa, L. Josephson, A. Rosenzweig, R. Weissleder, and V. Ntziachristos, “Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo,” Circulation 115(11), 1384–1391 (2007).
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B. Li, M. Abran, C. Matteau-Pelletier, L. Rouleau, T. Lam, R. Sharma, E. Rhéaume, A. Kakkar, J.-C. Tardif, and F. Lesage, “Low-cost three-dimensional imaging system combining fluorescence and ultrasound,” J. Biomed. Opt. 16(12), 126010 (2011).
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B. P. Flynn, A. V. DSouza, S. C. Kanick, S. C. Davis, and B. W. Pogue, “White light-informed optical properties improve ultrasound-guided fluorescence tomography of photoactive protoporphyrin IX,” J. Biomed. Opt. 18(4), 046008 (2013).
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V. S. Talanov, C. A. S. Regino, H. Kobayashi, M. Bernardo, P. L. Choyke, and M. W. Brechbiel, “Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging,” Nano Lett. 6(7), 1459–1463 (2006).
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Lam, T.

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Lesage, F.

B. Li, M. Abran, C. Matteau-Pelletier, L. Rouleau, T. Lam, R. Sharma, E. Rhéaume, A. Kakkar, J.-C. Tardif, and F. Lesage, “Low-cost three-dimensional imaging system combining fluorescence and ultrasound,” J. Biomed. Opt. 16(12), 126010 (2011).
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J.-C. Tardif, F. Lesage, F. Harel, P. Romeo, and J. Pressacco, “Imaging biomarkers in atherosclerosis trials,” Circ Cardiovasc Imaging 4(3), 319–333 (2011).
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S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008).
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B. Li, M. Abran, C. Matteau-Pelletier, L. Rouleau, T. Lam, R. Sharma, E. Rhéaume, A. Kakkar, J.-C. Tardif, and F. Lesage, “Low-cost three-dimensional imaging system combining fluorescence and ultrasound,” J. Biomed. Opt. 16(12), 126010 (2011).
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Libby, P.

F. A. Jaffer, P. Libby, and R. Weissleder, “Optical and multimodality molecular imaging: insights into atherosclerosis,” Arterioscler. Thromb. Vasc. Biol. 29(7), 1017–1024 (2009).
[Crossref] [PubMed]

Lin, Y.

Y. Lin, M. T. Ghijsen, H. Gao, N. Liu, O. Nalcioglu, and G. Gulsen, “A photo-multiplier tube-based hybrid MRI and frequency domain fluorescence tomography system for small animal imaging,” Phys. Med. Biol. 56(15), 4731–4747 (2011).
[Crossref] [PubMed]

Y. Lin, W. C. Barber, J. S. Iwanczyk, W. W. Roeck, O. Nalcioglu, and G. Gulsen, “Quantitative fluorescence tomography using a trimodality system: in vivo validation,” J. Biomed. Opt. 15(4), 040503 (2010).
[Crossref] [PubMed]

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Y. Lin, M. T. Ghijsen, H. Gao, N. Liu, O. Nalcioglu, and G. Gulsen, “A photo-multiplier tube-based hybrid MRI and frequency domain fluorescence tomography system for small animal imaging,” Phys. Med. Biol. 56(15), 4731–4747 (2011).
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D. A. Sanan, D. L. Newland, R. Tao, S. Marcovina, J. Wang, V. Mooser, R. E. Hammer, and H. H. Hobbs, “Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a),” Proc. Natl. Acad. Sci. U.S.A. 95(8), 4544–4549 (1998).
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B. Li, M. Abran, C. Matteau-Pelletier, L. Rouleau, T. Lam, R. Sharma, E. Rhéaume, A. Kakkar, J.-C. Tardif, and F. Lesage, “Low-cost three-dimensional imaging system combining fluorescence and ultrasound,” J. Biomed. Opt. 16(12), 126010 (2011).
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S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008).
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D. A. Sanan, D. L. Newland, R. Tao, S. Marcovina, J. Wang, V. Mooser, R. E. Hammer, and H. H. Hobbs, “Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a),” Proc. Natl. Acad. Sci. U.S.A. 95(8), 4544–4549 (1998).
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D. E. Sosnovik, M. Nahrendorf, N. Deliolanis, M. Novikov, E. Aikawa, L. Josephson, A. Rosenzweig, R. Weissleder, and V. Ntziachristos, “Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo,” Circulation 115(11), 1384–1391 (2007).
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Nalcioglu, O.

Y. Lin, M. T. Ghijsen, H. Gao, N. Liu, O. Nalcioglu, and G. Gulsen, “A photo-multiplier tube-based hybrid MRI and frequency domain fluorescence tomography system for small animal imaging,” Phys. Med. Biol. 56(15), 4731–4747 (2011).
[Crossref] [PubMed]

Y. Lin, W. C. Barber, J. S. Iwanczyk, W. W. Roeck, O. Nalcioglu, and G. Gulsen, “Quantitative fluorescence tomography using a trimodality system: in vivo validation,” J. Biomed. Opt. 15(4), 040503 (2010).
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D. A. Sanan, D. L. Newland, R. Tao, S. Marcovina, J. Wang, V. Mooser, R. E. Hammer, and H. H. Hobbs, “Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a),” Proc. Natl. Acad. Sci. U.S.A. 95(8), 4544–4549 (1998).
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D. E. Sosnovik, M. Nahrendorf, N. Deliolanis, M. Novikov, E. Aikawa, L. Josephson, A. Rosenzweig, R. Weissleder, and V. Ntziachristos, “Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo,” Circulation 115(11), 1384–1391 (2007).
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A. Ale, V. Ermolayev, N. C. Deliolanis, and V. Ntziachristos, “Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer,” J. Biomed. Opt. 18(5), 056006 (2013).
[Crossref] [PubMed]

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography,” Nat. Methods 9(6), 615–620 (2012).
[Crossref] [PubMed]

K. Radrich, A. Ale, V. Ermolayev, and V. Ntziachristos, “Improving limited-projection-angle fluorescence molecular tomography using a co-registered x-ray computed tomography scan,” J. Biomed. Opt. 17(12), 126011 (2012).
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A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, “Imaging performance of a hybrid x-ray computed tomography-fluorescence molecular tomography system using priors,” Med. Phys. 37(5), 1976–1986 (2010).
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D. E. Sosnovik, M. Nahrendorf, N. Deliolanis, M. Novikov, E. Aikawa, L. Josephson, A. Rosenzweig, R. Weissleder, and V. Ntziachristos, “Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo,” Circulation 115(11), 1384–1391 (2007).
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V. Ntziachristos and R. Weissleder, “Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation,” Opt. Lett. 26(12), 893–895 (2001).
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P. C. Hansen and D. P. O’Leary, “The use of the L-curve in the regularization of discrete ill-posed problems,” SIAM J. Sci. Comput. 14(6), 1487–1503 (1993).
[Crossref]

Paulsen, K. D.

C. M. Carpenter, R. Rakow-Penner, S. Jiang, B. L. Daniel, B. W. Pogue, G. H. Glover, and K. D. Paulsen, “Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study,” J. Biomed. Opt. 15(3), 036026 (2010).
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S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008).
[Crossref] [PubMed]

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, and K. D. Paulsen, “Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography,” Med. Phys. 34(6), 2085–2098 (2007).
[Crossref] [PubMed]

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15(7), 4066–4082 (2007).
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Peltie, P.

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J. M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt. 14(6), 064001 (2009).
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B. P. Flynn, A. V. DSouza, S. C. Kanick, S. C. Davis, and B. W. Pogue, “White light-informed optical properties improve ultrasound-guided fluorescence tomography of photoactive protoporphyrin IX,” J. Biomed. Opt. 18(4), 046008 (2013).
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F. Leblond, K. M. Tichauer, R. W. Holt, F. El-Ghussein, and B. W. Pogue, “Toward whole-body optical imaging of rats using single-photon counting fluorescence tomography,” Opt. Lett. 36(19), 3723–3725 (2011).
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C. M. Carpenter, R. Rakow-Penner, S. Jiang, B. L. Daniel, B. W. Pogue, G. H. Glover, and K. D. Paulsen, “Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study,” J. Biomed. Opt. 15(3), 036026 (2010).
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S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008).
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S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15(7), 4066–4082 (2007).
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P. K. Yalavarthy, B. W. Pogue, H. Dehghani, and K. D. Paulsen, “Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography,” Med. Phys. 34(6), 2085–2098 (2007).
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J.-C. Tardif, F. Lesage, F. Harel, P. Romeo, and J. Pressacco, “Imaging biomarkers in atherosclerosis trials,” Circ Cardiovasc Imaging 4(3), 319–333 (2011).
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Pyka, T.

Radrich, K.

K. Radrich, A. Ale, V. Ermolayev, and V. Ntziachristos, “Improving limited-projection-angle fluorescence molecular tomography using a co-registered x-ray computed tomography scan,” J. Biomed. Opt. 17(12), 126011 (2012).
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C. M. Carpenter, R. Rakow-Penner, S. Jiang, B. L. Daniel, B. W. Pogue, G. H. Glover, and K. D. Paulsen, “Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study,” J. Biomed. Opt. 15(3), 036026 (2010).
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[Crossref] [PubMed]

Rhéaume, E.

B. Li, M. Abran, C. Matteau-Pelletier, L. Rouleau, T. Lam, R. Sharma, E. Rhéaume, A. Kakkar, J.-C. Tardif, and F. Lesage, “Low-cost three-dimensional imaging system combining fluorescence and ultrasound,” J. Biomed. Opt. 16(12), 126010 (2011).
[Crossref] [PubMed]

Ripoll, J.

J. F. P.-J. Abascal, J. Aguirre, J. Chamorro-Servent, M. Schweiger, S. Arridge, J. Ripoll, J. J. Vaquero, and M. Desco, “Influence of absorption and scattering on the quantification of fluorescence diffuse optical tomography using normalized data,” J. Biomed. Opt. 17(3), 036013 (2012).
[Crossref] [PubMed]

Roeck, W. W.

Y. Lin, W. C. Barber, J. S. Iwanczyk, W. W. Roeck, O. Nalcioglu, and G. Gulsen, “Quantitative fluorescence tomography using a trimodality system: in vivo validation,” J. Biomed. Opt. 15(4), 040503 (2010).
[Crossref] [PubMed]

Romeo, P.

J.-C. Tardif, F. Lesage, F. Harel, P. Romeo, and J. Pressacco, “Imaging biomarkers in atherosclerosis trials,” Circ Cardiovasc Imaging 4(3), 319–333 (2011).
[Crossref] [PubMed]

Rosenzweig, A.

D. E. Sosnovik, M. Nahrendorf, N. Deliolanis, M. Novikov, E. Aikawa, L. Josephson, A. Rosenzweig, R. Weissleder, and V. Ntziachristos, “Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo,” Circulation 115(11), 1384–1391 (2007).
[Crossref] [PubMed]

Rouleau, L.

B. Li, M. Abran, C. Matteau-Pelletier, L. Rouleau, T. Lam, R. Sharma, E. Rhéaume, A. Kakkar, J.-C. Tardif, and F. Lesage, “Low-cost three-dimensional imaging system combining fluorescence and ultrasound,” J. Biomed. Opt. 16(12), 126010 (2011).
[Crossref] [PubMed]

Sanan, D. A.

D. A. Sanan, D. L. Newland, R. Tao, S. Marcovina, J. Wang, V. Mooser, R. E. Hammer, and H. H. Hobbs, “Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a),” Proc. Natl. Acad. Sci. U.S.A. 95(8), 4544–4549 (1998).
[Crossref] [PubMed]

Sanz, J.

J. Sanz and Z. A. Fayad, “Imaging of atherosclerotic cardiovascular disease,” Nature 451(7181), 953–957 (2008).
[Crossref] [PubMed]

Sarantopoulos, A.

A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, “Imaging performance of a hybrid x-ray computed tomography-fluorescence molecular tomography system using priors,” Med. Phys. 37(5), 1976–1986 (2010).
[Crossref] [PubMed]

Saroul, L.

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J. M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt. 14(6), 064001 (2009).
[Crossref] [PubMed]

Schulz, R.

Schulz, R. B.

A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, “Imaging performance of a hybrid x-ray computed tomography-fluorescence molecular tomography system using priors,” Med. Phys. 37(5), 1976–1986 (2010).
[Crossref] [PubMed]

Schweiger, M.

J. F. P.-J. Abascal, J. Aguirre, J. Chamorro-Servent, M. Schweiger, S. Arridge, J. Ripoll, J. J. Vaquero, and M. Desco, “Influence of absorption and scattering on the quantification of fluorescence diffuse optical tomography using normalized data,” J. Biomed. Opt. 17(3), 036013 (2012).
[Crossref] [PubMed]

Sharma, R.

B. Li, M. Abran, C. Matteau-Pelletier, L. Rouleau, T. Lam, R. Sharma, E. Rhéaume, A. Kakkar, J.-C. Tardif, and F. Lesage, “Low-cost three-dimensional imaging system combining fluorescence and ultrasound,” J. Biomed. Opt. 16(12), 126010 (2011).
[Crossref] [PubMed]

Sosnovik, D. E.

D. E. Sosnovik, M. Nahrendorf, N. Deliolanis, M. Novikov, E. Aikawa, L. Josephson, A. Rosenzweig, R. Weissleder, and V. Ntziachristos, “Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo,” Circulation 115(11), 1384–1391 (2007).
[Crossref] [PubMed]

Springett, R.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008).
[Crossref] [PubMed]

Tai, X.-C.

J. Yuan, E. Bae, and X.-C. Tai, “A study on continuous max-flow and min-cut approaches,” in 2010 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), 2217–2224 (2010).
[Crossref]

Talanov, V. S.

V. S. Talanov, C. A. S. Regino, H. Kobayashi, M. Bernardo, P. L. Choyke, and M. W. Brechbiel, “Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging,” Nano Lett. 6(7), 1459–1463 (2006).
[Crossref] [PubMed]

Tao, R.

D. A. Sanan, D. L. Newland, R. Tao, S. Marcovina, J. Wang, V. Mooser, R. E. Hammer, and H. H. Hobbs, “Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a),” Proc. Natl. Acad. Sci. U.S.A. 95(8), 4544–4549 (1998).
[Crossref] [PubMed]

Tardif, J.-C.

J.-C. Tardif, F. Lesage, F. Harel, P. Romeo, and J. Pressacco, “Imaging biomarkers in atherosclerosis trials,” Circ Cardiovasc Imaging 4(3), 319–333 (2011).
[Crossref] [PubMed]

B. Li, M. Abran, C. Matteau-Pelletier, L. Rouleau, T. Lam, R. Sharma, E. Rhéaume, A. Kakkar, J.-C. Tardif, and F. Lesage, “Low-cost three-dimensional imaging system combining fluorescence and ultrasound,” J. Biomed. Opt. 16(12), 126010 (2011).
[Crossref] [PubMed]

Tichauer, K. M.

Tuttle, S. B.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008).
[Crossref] [PubMed]

Vaquero, J. J.

J. F. P.-J. Abascal, J. Aguirre, J. Chamorro-Servent, M. Schweiger, S. Arridge, J. Ripoll, J. J. Vaquero, and M. Desco, “Influence of absorption and scattering on the quantification of fluorescence diffuse optical tomography using normalized data,” J. Biomed. Opt. 17(3), 036013 (2012).
[Crossref] [PubMed]

Vray, D.

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J. M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt. 14(6), 064001 (2009).
[Crossref] [PubMed]

Wang, J.

S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15(7), 4066–4082 (2007).
[Crossref] [PubMed]

D. A. Sanan, D. L. Newland, R. Tao, S. Marcovina, J. Wang, V. Mooser, R. E. Hammer, and H. H. Hobbs, “Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a),” Proc. Natl. Acad. Sci. U.S.A. 95(8), 4544–4549 (1998).
[Crossref] [PubMed]

Weissleder, R.

F. A. Jaffer, P. Libby, and R. Weissleder, “Optical and multimodality molecular imaging: insights into atherosclerosis,” Arterioscler. Thromb. Vasc. Biol. 29(7), 1017–1024 (2009).
[Crossref] [PubMed]

D. E. Sosnovik, M. Nahrendorf, N. Deliolanis, M. Novikov, E. Aikawa, L. Josephson, A. Rosenzweig, R. Weissleder, and V. Ntziachristos, “Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo,” Circulation 115(11), 1384–1391 (2007).
[Crossref] [PubMed]

V. Ntziachristos and R. Weissleder, “Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation,” Opt. Lett. 26(12), 893–895 (2001).
[Crossref] [PubMed]

Yalavarthy, P. K.

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, and K. D. Paulsen, “Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography,” Med. Phys. 34(6), 2085–2098 (2007).
[Crossref] [PubMed]

Yamada, Y.

Yuan, J.

J. Yuan, E. Bae, and X.-C. Tai, “A study on continuous max-flow and min-cut approaches,” in 2010 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), 2217–2224 (2010).
[Crossref]

Zhao, H.

Appl. Opt. (1)

Arterioscler. Thromb. Vasc. Biol. (1)

F. A. Jaffer, P. Libby, and R. Weissleder, “Optical and multimodality molecular imaging: insights into atherosclerosis,” Arterioscler. Thromb. Vasc. Biol. 29(7), 1017–1024 (2009).
[Crossref] [PubMed]

Biomed. Opt. Express (1)

Circ Cardiovasc Imaging (1)

J.-C. Tardif, F. Lesage, F. Harel, P. Romeo, and J. Pressacco, “Imaging biomarkers in atherosclerosis trials,” Circ Cardiovasc Imaging 4(3), 319–333 (2011).
[Crossref] [PubMed]

Circulation (1)

D. E. Sosnovik, M. Nahrendorf, N. Deliolanis, M. Novikov, E. Aikawa, L. Josephson, A. Rosenzweig, R. Weissleder, and V. Ntziachristos, “Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo,” Circulation 115(11), 1384–1391 (2007).
[Crossref] [PubMed]

J. Biomed. Opt. (8)

A. Ale, V. Ermolayev, N. C. Deliolanis, and V. Ntziachristos, “Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer,” J. Biomed. Opt. 18(5), 056006 (2013).
[Crossref] [PubMed]

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J. M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt. 14(6), 064001 (2009).
[Crossref] [PubMed]

B. Li, M. Abran, C. Matteau-Pelletier, L. Rouleau, T. Lam, R. Sharma, E. Rhéaume, A. Kakkar, J.-C. Tardif, and F. Lesage, “Low-cost three-dimensional imaging system combining fluorescence and ultrasound,” J. Biomed. Opt. 16(12), 126010 (2011).
[Crossref] [PubMed]

Y. Lin, W. C. Barber, J. S. Iwanczyk, W. W. Roeck, O. Nalcioglu, and G. Gulsen, “Quantitative fluorescence tomography using a trimodality system: in vivo validation,” J. Biomed. Opt. 15(4), 040503 (2010).
[Crossref] [PubMed]

B. P. Flynn, A. V. DSouza, S. C. Kanick, S. C. Davis, and B. W. Pogue, “White light-informed optical properties improve ultrasound-guided fluorescence tomography of photoactive protoporphyrin IX,” J. Biomed. Opt. 18(4), 046008 (2013).
[Crossref] [PubMed]

K. Radrich, A. Ale, V. Ermolayev, and V. Ntziachristos, “Improving limited-projection-angle fluorescence molecular tomography using a co-registered x-ray computed tomography scan,” J. Biomed. Opt. 17(12), 126011 (2012).
[Crossref] [PubMed]

J. F. P.-J. Abascal, J. Aguirre, J. Chamorro-Servent, M. Schweiger, S. Arridge, J. Ripoll, J. J. Vaquero, and M. Desco, “Influence of absorption and scattering on the quantification of fluorescence diffuse optical tomography using normalized data,” J. Biomed. Opt. 17(3), 036013 (2012).
[Crossref] [PubMed]

C. M. Carpenter, R. Rakow-Penner, S. Jiang, B. L. Daniel, B. W. Pogue, G. H. Glover, and K. D. Paulsen, “Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study,” J. Biomed. Opt. 15(3), 036026 (2010).
[Crossref] [PubMed]

Med. Phys. (2)

P. K. Yalavarthy, B. W. Pogue, H. Dehghani, and K. D. Paulsen, “Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography,” Med. Phys. 34(6), 2085–2098 (2007).
[Crossref] [PubMed]

A. Ale, R. B. Schulz, A. Sarantopoulos, and V. Ntziachristos, “Imaging performance of a hybrid x-ray computed tomography-fluorescence molecular tomography system using priors,” Med. Phys. 37(5), 1976–1986 (2010).
[Crossref] [PubMed]

Nano Lett. (1)

V. S. Talanov, C. A. S. Regino, H. Kobayashi, M. Bernardo, P. L. Choyke, and M. W. Brechbiel, “Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging,” Nano Lett. 6(7), 1459–1463 (2006).
[Crossref] [PubMed]

Nat. Methods (1)

A. Ale, V. Ermolayev, E. Herzog, C. Cohrs, M. H. de Angelis, and V. Ntziachristos, “FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography,” Nat. Methods 9(6), 615–620 (2012).
[Crossref] [PubMed]

Nature (1)

J. Sanz and Z. A. Fayad, “Imaging of atherosclerotic cardiovascular disease,” Nature 451(7181), 953–957 (2008).
[Crossref] [PubMed]

Opt. Express (2)

Opt. Lett. (3)

Phys. Med. Biol. (3)

G. Alexandrakis, F. R. Rannou, and A. F. Chatziioannou, “Tomographic bioluminescence imaging by use of a combined optical-PET (OPET) system: a computer simulation feasibility study,” Phys. Med. Biol. 50(17), 4225–4241 (2005).
[Crossref] [PubMed]

A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
[Crossref] [PubMed]

Y. Lin, M. T. Ghijsen, H. Gao, N. Liu, O. Nalcioglu, and G. Gulsen, “A photo-multiplier tube-based hybrid MRI and frequency domain fluorescence tomography system for small animal imaging,” Phys. Med. Biol. 56(15), 4731–4747 (2011).
[Crossref] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

D. A. Sanan, D. L. Newland, R. Tao, S. Marcovina, J. Wang, V. Mooser, R. E. Hammer, and H. H. Hobbs, “Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a),” Proc. Natl. Acad. Sci. U.S.A. 95(8), 4544–4549 (1998).
[Crossref] [PubMed]

Rev. Sci. Instrum. (1)

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, “Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue,” Rev. Sci. Instrum. 79(6), 064302 (2008).
[Crossref] [PubMed]

SIAM J. Sci. Comput. (1)

P. C. Hansen and D. P. O’Leary, “The use of the L-curve in the regularization of discrete ill-posed problems,” SIAM J. Sci. Comput. 14(6), 1487–1503 (1993).
[Crossref]

Other (2)

S. A. Prahl, “Online resource: http://omlc.ogi.edu/spectra”.

J. Yuan, E. Bae, and X.-C. Tai, “A study on continuous max-flow and min-cut approaches,” in 2010 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), 2217–2224 (2010).
[Crossref]

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Figures (9)

Fig. 1
Fig. 1

Schematic (top) and photograph (bottom) of the FMT system. GM: Galvo mirror; EF: excitation fibers; DF: detection fibers; LD: laser driver; FW: Filter wheel.

Fig. 2
Fig. 2

Schematic diagram (left, top side) and photograph (right) of the optical probe working in an experiment. AH: animal holder; AP: animal plate; FMR: fiducial marker.

Fig. 3
Fig. 3

(a) Representative axial MR slice of ATX #2; (b) segmented image; (c) resampled segmented image with 1 mm voxel resolution.

Fig. 4
Fig. 4

Schematic diagram of the phantom: (a) view of X-Y plane; (b) view of X-Z plane. The attenuation and fluorescence inclusions are denoted by Diff and Fluo, respectively.

Fig. 5
Fig. 5

(a) A synthetic fluorescence slice of the phantom; (b) the corresponding slices of the reconstruction with the heterogeneous models (b), and with the homogeneous model (c), respectively; (d) plot of reconstructed values along the red dashed line. (e) CNR was compared with λ for both models.

Fig. 6
Fig. 6

(a) Ex vivo images of the fluorescent tubes were overlaid with transparency (alpha = 0.5) on the photographs of tubes, respectively; (b) the average reconstructed values (both models) of the fluorescent tubes were normalized of the maximum being 1, to compare with the ex vivo measurement (reference).

Fig. 7
Fig. 7

(a) Three orthogonal MR slices are shown: axial slice (Y-Z), coronal slice (X-Y) and sagittal slice (X-Z). The arrow of the X axes points to tail of the mouse; and the arrow of the Z axes points to abdomen. The tube was indicated by the red arrow; (b) the reconstructions with the heterogeneous models were overlaid with transparency (alpha = 0.5) on the MR slices, respectively; (c) the reconstructions with the homogeneous models were overlaid with transparency (alpha = 0.5) on the MR slices, respectively.

Fig. 8
Fig. 8

The images in the first column are the MR slices for each mouse. Heart and part of aorta of ATX #1 were denoted by red arrows. In the second column, the reconstructed εηC with the heterogeneous models were overlaid with transparency (alpha = 0.5) on the MR slices, respectively. Three orthogonal MR slices were chosen for each mouse: axial slice (Y-Z), coronal slice (X-Y) and sagittal slice (X-Z).

Fig. 9
Fig. 9

The hearts and aortas of the four mice were imaged ex vivo. In the first row, the ex vivo fluorescence images were overlaid with transparency (alpha = 0.5) on the corresponding photographs. Shown by the curves below, the average reconstructed εηC of the hearts and aortas for all mice were normalized with the maximum being 1 to compare with the ex vivo measurement.

Tables (1)

Tables Icon

Table 1 Dimension and optical properties of the phantom.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

Ω= Φ meas Wχ 2 +λ Lχ 2 ,
χ i+1 = [ W T W+λ L T L] 1 W T ( Φ i meas Φ i C )+ χ i ,
W= V G x ( r s ,r) G m (r, r d ) d 3 r G x ( r s , r d ) .

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