Abstract

The relationship between scleral birefringence and biometric parameters of human eyes in vivo is investigated. Scleral birefringence near the limbus of 21 healthy human eyes was measured using polarization-sensitive optical coherence tomography. Spherical equivalent refractive error, axial eye length, and intraocular pressure (IOP) were measured in all subjects. IOP and scleral birefringence of human eyes in vivo was found to have statistically significant correlations (r = −0.63, P = 0.002). The slope of linear regression was −2.4 × 10−2 deg/μm/mmHg. Neither spherical equivalent refractive error nor axial eye length had significant correlations with scleral birefringence. To evaluate the direct influence of IOP to scleral birefringence, scleral birefringence of 16 ex vivo porcine eyes was measured under controlled IOP of 5−60 mmHg. In these ex vivo porcine eyes, the mean linear regression slope between controlled IOP and scleral birefringence was −9.9 × 10−4 deg/μm/mmHg. In addition, porcine scleral collagen fibers were observed with second-harmonic-generation (SHG) microscopy. SHG images of porcine sclera, measured on the external surface at the superior side to the cornea, showed highly aligned collagen fibers parallel to the limbus. In conclusion, scleral birefringence of healthy human eyes was correlated with IOP, indicating that the ultrastructure of scleral collagen was correlated with IOP. It remains to show whether scleral collagen ultrastructure of human eyes is affected by IOP as a long-term effect.

© 2014 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. N. A. McBrien and A. Gentle, “Role of the sclera in the development and pathological complications of myopia,” Prog. Retin. Eye Res.22(3), 307–338 (2003).
    [CrossRef] [PubMed]
  2. C. F. Burgoyne, J. C. Downs, A. J. Bellezza, J. K. Suh, and R. T. Hart, “The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage,” Prog. Retin. Eye Res.24(1), 39–73 (2005).
    [CrossRef] [PubMed]
  3. J. A. Rada, S. Shelton, and T. T. Norton, “The sclera and myopia,” Exp. Eye Res.82(2), 185–200 (2006).
    [CrossRef] [PubMed]
  4. J. T. Siegwart and T. T. Norton, “Regulation of the mechanical properties of tree shrew sclera by the visual environment,” Vision Res.39(2), 387–407 (1999).
    [CrossRef] [PubMed]
  5. N. A. McBrien, L. M. Cornell, and A. Gentle, “Structural and ultrastructural changes to the sclera in a mammalian model of high myopia,” Invest. Ophthalmol. Vis. Sci.42(10), 2179–2187 (2001).
    [PubMed]
  6. J. K. Pijanka, B. Coudrillier, K. Ziegler, T. Sorensen, K. M. Meek, T. D. Nguyen, H. A. Quigley, and C. Boote, “Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae,” Invest. Ophthalmol. Vis. Sci.53(9), 5258–5270 (2012).
    [CrossRef] [PubMed]
  7. J. C. Downs, J.-K. F. Suh, K. A. Thomas, A. J. Bellezza, R. T. Hart, and C. F. Burgoyne, “Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes,” Invest. Ophthalmol. Vis. Sci.46(2), 540–546 (2005).
    [CrossRef] [PubMed]
  8. B. Coudrillier, J. Tian, S. Alexander, K. M. Myers, H. A. Quigley, and T. D. Nguyen, “Biomechanics of the human posterior sclera: Age- and glaucoma-related changes measured using inflation testing,” Invest. Ophthalmol. Vis. Sci.53(4), 1714–1728 (2012).
    [CrossRef] [PubMed]
  9. A. J. Bellezza, C. J. Rintalan, H. W. Thompson, J. C. Downs, R. T. Hart, and C. F. Burgoyne, “Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma,” Invest. Ophthalmol. Vis. Sci.44(2), 623–637 (2003).
    [CrossRef] [PubMed]
  10. H. Yang, H. Thompson, M. D. Roberts, I. A. Sigal, J. C. Downs, and C. F. Burgoyne, “Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions,” Invest. Ophthalmol. Vis. Sci.52(1), 345–363 (2011).
    [CrossRef] [PubMed]
  11. H. A. Quigley, M. E. Dorman-Pease, and A. E. Brown, “Quantitative study of collagen and elastin of the optic nerve head and sclera in human and experimental monkey glaucoma,” Curr. Eye Res.10(9), 877–888 (1991).
    [CrossRef] [PubMed]
  12. S. Nagase, M. Yamanari, R. Tanaka, T. Yasui, M. Miura, T. Iwasaki, H. Goto, and Y. Yasuno, “Anisotropic alteration of scleral birefringence to uniaxial mechanical strain,” PLoS ONE8(3), e58716 (2013).
    [CrossRef] [PubMed]
  13. M. Yamanari, K. Ishii, S. Fukuda, Y. Lim, L. Duan, S. Makita, M. Miura, T. Oshika, and Y. Yasuno, “Optical rheology of porcine sclera by birefringence imaging,” PLoS ONE7(9), e44026 (2012).
    [CrossRef] [PubMed]
  14. R. Oldenbourg, E. D. Salmon, and P. T. Tran, “Birefringence of single and bundled microtubules,” Biophys. J.74(1), 645–654 (1998).
    [CrossRef] [PubMed]
  15. S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
    [CrossRef] [PubMed]
  16. C. J. Doillon, M. G. Dunn, E. Bender, and F. H. Silver, “Collagen fiber formation in repair tissue: development of strength and toughness,” Coll. Relat. Res.5(6), 481–492 (1985).
    [CrossRef] [PubMed]
  17. D. A. Parry, “The molecular and fibrillar structure of collagen and its relationship to the mechanical properties of connective tissue,” Biophys. Chem.29(1-2), 195–209 (1988).
    [CrossRef] [PubMed]
  18. G. D. Pins, D. L. Christiansen, R. Patel, and F. H. Silver, “Self-assembly of collagen fibers. influence of fibrillar alignment and decorin on mechanical properties,” Biophys. J.73(4), 2164–2172 (1997).
    [CrossRef] [PubMed]
  19. E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt.9(1), 94–102 (2004).
    [CrossRef] [PubMed]
  20. Y. Yasuno, M. Yamanari, K. Kawana, M. Miura, S. Fukuda, S. Makita, S. Sakai, and T. Oshika, “Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography,” J. Biomed. Opt.15(6), 061705 (2010).
    [CrossRef] [PubMed]
  21. M. G. Ducros, J. D. Marsack, H. G. Rylander, S. L. Thomsen, and T. E. Milner, “Primate retina imaging with polarization-sensitive optical coherence tomography,” J. Opt. Soc. Am. A18(12), 2945–2956 (2001).
    [CrossRef]
  22. B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45(8), 2606–2612 (2004).
    [CrossRef] [PubMed]
  23. M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt.13(1), 014013 (2008).
    [CrossRef] [PubMed]
  24. M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci.49(6), 2661–2667 (2008).
    [CrossRef] [PubMed]
  25. Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express17(5), 3980–3996 (2009).
    [CrossRef] [PubMed]
  26. Y. Lim, M. Yamanari, S. Fukuda, Y. Kaji, T. Kiuchi, M. Miura, T. Oshika, and Y. Yasuno, “Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(8), 2392–2402 (2011).
    [CrossRef] [PubMed]
  27. M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express16(8), 5892–5906 (2008).
    [CrossRef] [PubMed]
  28. M. Yamanari, Y. Lim, S. Makita, and Y. Yasuno, “Visualization of phase retardation of deep posterior eye by polarization-sensitive swept-source optical coherence tomography with 1- µm probe,” Opt. Express17(15), 12385–12396 (2009).
    [CrossRef] [PubMed]
  29. M. Yamanari, S. Makita, Y. Lim, and Y. Yasuno, “Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulation,” Opt. Express18(13), 13964–13980 (2010).
    [CrossRef] [PubMed]
  30. M. Miura, M. Yamanari, T. Iwasaki, M. Itoh, T. Yatagai, and Y. Yasuno, “Polarization-sensitive optical coherence tomography of necrotizing scleritis,” Ophthalmic Surg. Lasers Imaging40(6), 607–610 (2009).
    [CrossRef] [PubMed]
  31. S. Makita, M. Yamanari, and Y. Yasuno, “Generalized jones matrix optical coherence tomography: performance and local birefringence imaging,” Opt. Express18(2), 854–876 (2010).
    [CrossRef] [PubMed]
  32. L. Duan, S. Makita, M. Yamanari, Y. Lim, and Y. Yasuno, “Monte-carlo-based phase retardation estimator for polarization sensitive optical coherence tomography,” Opt. Express19(17), 16330–16345 (2011).
    [CrossRef] [PubMed]
  33. A. Alm and S. F. Nilsson, “Uveoscleral outflow--a review,” Exp. Eye Res.88(4), 760–768 (2009).
    [CrossRef] [PubMed]
  34. S. Sakai, M. Yamanari, Y. Lim, N. Nakagawa, and Y. Yasuno, “In vivo evaluation of human skin anisotropy by polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(9), 2623–2631 (2011).
    [CrossRef] [PubMed]
  35. T. W. Olsen, S. Sanderson, X. Feng, and W. C. Hubbard, “Porcine sclera: Thickness and surface area,” Invest. Ophthalmol. Vis. Sci.43(8), 2529–2532 (2002).
    [PubMed]
  36. B. K. Pierscionek, M. Asejczyk-Widlicka, and R. A. Schachar, “The effect of changing intraocular pressure on the corneal and scleral curvatures in the fresh porcine eye,” Br. J. Ophthalmol.91(6), 801–803 (2007).
    [CrossRef] [PubMed]
  37. D. S. Schultz, J. C. Lotz, S. M. Lee, M. L. Trinidad, and J. M. Stewart, “Structural factors that mediate scleral stiffness,” Invest. Ophthalmol. Vis. Sci.49(10), 4232–4236 (2008).
    [CrossRef] [PubMed]
  38. S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, and P. Santi, “Porcine sclera as a model of human sclera for in vitro transport experiments: histology, sem, and comparative permeability,” Mol. Vis.15, 259–266 (2009).
    [PubMed]
  39. M. J. A. Girard, J.-K. F. Suh, M. Bottlang, C. F. Burgoyne, and J. C. Downs, “Biomechanical changes in the sclera of monkey eyes exposed to chronic iop elevations,” Invest. Ophthalmol. Vis. Sci.52(8), 5656–5669 (2011).
    [CrossRef] [PubMed]
  40. P. M. Pinsky, D. van der Heide, and D. Chernyak, “Computational modeling of mechanical anisotropy in the cornea and sclera,” J. Cataract Refract. Surg.31(1), 136–145 (2005).
    [CrossRef] [PubMed]
  41. R. Grytz and G. Meschke, “A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shells,” Biomech. Model. Mechanobiol.9(2), 225–235 (2010).
    [CrossRef] [PubMed]
  42. Collaborative Normal-Tension Glaucoma Study Group, “Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures,” Am. J. Ophthalmol.126(4), 487–497 (1998).
    [CrossRef] [PubMed]
  43. Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
    [CrossRef] [PubMed]
  44. M. J. A. Girard, J. C. Downs, C. F. Burgoyne, and J.-K. F. Suh, “Peripapillary and posterior scleral mechanics--part i: Development of an anisotropic hyperelastic constitutive model,” J. Biomech. Eng.131(5), 051011 (2009).
    [CrossRef] [PubMed]
  45. B. Coudrillier, C. Boote, H. A. Quigley, and T. D. Nguyen, “Scleral anisotropy and its effects on the mechanical response of the optic nerve head,” Biomech. Model. Mechanobiol.12(5), 941–963 (2013).
    [CrossRef] [PubMed]
  46. M. J. Hogan, J. A. Alvarado, and J. E. Weddell, Histology of the human eye: an atlas and textbook (Saunders, 1971).
  47. H. A. Quigley, E. M. Addicks, W. R. Green, and A. E. Maumenee, “Optic nerve damage in human glaucoma. Ii. the site of injury and susceptibility to damage,” Arch. Ophthalmol.99(4), 635–649 (1981).
    [CrossRef] [PubMed]
  48. Y. Lim, Y.-J. Hong, L. Duan, M. Yamanari, and Y. Yasuno, “Passive component based multifunctional jones matrix swept source optical coherence tomography for doppler and polarization imaging,” Opt. Lett.37(11), 1958–1960 (2012).
    [CrossRef] [PubMed]
  49. T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
    [CrossRef] [PubMed]
  50. M. C. van Turnhout, S. Kranenbarg, and J. L. van Leeuwen, “Modeling optical behavior of birefringent biological tissues for evaluation of quantitative polarized light microscopy,” J. Biomed. Opt.14(5), 054018 (2009).
    [CrossRef] [PubMed]
  51. P. Watson and B. Hazleman, The Sclera and Systemic Disorders (Jp Medical Pub, 2012).
  52. R. H. Newton and K. M. Meek, “The integration of the corneal and limbal fibrils in the human eye,” Biophys. J.75(5), 2508–2512 (1998).
    [CrossRef] [PubMed]
  53. D. Yan, S. McPheeters, G. Johnson, U. Utzinger, and J. P. Vande Geest, “Microstructural differences in the human posterior sclera as a function of age and race,” Invest. Ophthalmol. Vis. Sci.52(2), 821–829 (2011).
    [CrossRef] [PubMed]
  54. M. J. A. Girard, A. Dahlmann-Noor, S. Rayapureddi, J. A. Bechara, B. M. E. Bertin, H. Jones, J. Albon, P. T. Khaw, and C. R. Ethier, “Quantitative mapping of scleral fiber orientation in normal rat eyes,” Invest. Ophthalmol. Vis. Sci.52(13), 9684–9693 (2011).
    [CrossRef] [PubMed]
  55. N. Morishige, A. J. Wahlert, M. C. Kenney, D. J. Brown, K. Kawamoto, T.-i. Chikama, T. Nishida, and J. V. Jester, “Second-harmonic imaging microscopy of normal human and keratoconus cornea,” Invest. Ophthalmol. Vis. Sci.48(3), 1087–1094 (2007).
    [CrossRef] [PubMed]
  56. J. M. Bueno, E. J. Gualda, A. Giakoumaki, P. Pérez-Merino, S. Marcos, and P. Artal, “Multiphoton microscopy of ex vivo corneas after collagen cross-linking,” Invest. Ophthalmol. Vis. Sci.52(8), 5325–5331 (2011).
    [CrossRef] [PubMed]
  57. N. Morishige, N. Yamada, X. Zhang, Y. Morita, N. Yamada, K. Kimura, A. Takahara, and K.-H. Sonoda, “Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy,” Invest. Ophthalmol. Vis. Sci.53(8), 4998–5003 (2012).
    [CrossRef] [PubMed]
  58. M. Han, G. Giese, and J. Bille, “Second harmonic generation imaging of collagen fibrils in cornea and sclera,” Opt. Express13(15), 5791–5797 (2005).
    [CrossRef] [PubMed]
  59. S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
    [CrossRef] [PubMed]
  60. A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express17(20), 17426–17440 (2009).
    [CrossRef] [PubMed]
  61. L. Duan, M. Yamanari, and Y. Yasuno, “Automated phase retardation oriented segmentation of chorio-scleral interface by polarization sensitive optical coherence tomography,” Opt. Express20(3), 3353–3366 (2012).
    [CrossRef] [PubMed]
  62. T. Torzicky, M. Pircher, S. Zotter, M. Bonesi, E. Götzinger, and C. K. Hitzenberger, “Automated measurement of choroidal thickness in the human eye by polarization sensitive optical coherence tomography,” Opt. Express20(7), 7564–7574 (2012).
    [CrossRef] [PubMed]
  63. J. Liu and C. J. Roberts, “Influence of corneal biomechanical properties on intraocular pressure measurement,” J. Cataract Refract. Surg.31(1), 146–155 (2005).
    [CrossRef] [PubMed]

2013

S. Nagase, M. Yamanari, R. Tanaka, T. Yasui, M. Miura, T. Iwasaki, H. Goto, and Y. Yasuno, “Anisotropic alteration of scleral birefringence to uniaxial mechanical strain,” PLoS ONE8(3), e58716 (2013).
[CrossRef] [PubMed]

B. Coudrillier, C. Boote, H. A. Quigley, and T. D. Nguyen, “Scleral anisotropy and its effects on the mechanical response of the optic nerve head,” Biomech. Model. Mechanobiol.12(5), 941–963 (2013).
[CrossRef] [PubMed]

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

2012

N. Morishige, N. Yamada, X. Zhang, Y. Morita, N. Yamada, K. Kimura, A. Takahara, and K.-H. Sonoda, “Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy,” Invest. Ophthalmol. Vis. Sci.53(8), 4998–5003 (2012).
[CrossRef] [PubMed]

L. Duan, M. Yamanari, and Y. Yasuno, “Automated phase retardation oriented segmentation of chorio-scleral interface by polarization sensitive optical coherence tomography,” Opt. Express20(3), 3353–3366 (2012).
[CrossRef] [PubMed]

T. Torzicky, M. Pircher, S. Zotter, M. Bonesi, E. Götzinger, and C. K. Hitzenberger, “Automated measurement of choroidal thickness in the human eye by polarization sensitive optical coherence tomography,” Opt. Express20(7), 7564–7574 (2012).
[CrossRef] [PubMed]

Y. Lim, Y.-J. Hong, L. Duan, M. Yamanari, and Y. Yasuno, “Passive component based multifunctional jones matrix swept source optical coherence tomography for doppler and polarization imaging,” Opt. Lett.37(11), 1958–1960 (2012).
[CrossRef] [PubMed]

M. Yamanari, K. Ishii, S. Fukuda, Y. Lim, L. Duan, S. Makita, M. Miura, T. Oshika, and Y. Yasuno, “Optical rheology of porcine sclera by birefringence imaging,” PLoS ONE7(9), e44026 (2012).
[CrossRef] [PubMed]

J. K. Pijanka, B. Coudrillier, K. Ziegler, T. Sorensen, K. M. Meek, T. D. Nguyen, H. A. Quigley, and C. Boote, “Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae,” Invest. Ophthalmol. Vis. Sci.53(9), 5258–5270 (2012).
[CrossRef] [PubMed]

B. Coudrillier, J. Tian, S. Alexander, K. M. Myers, H. A. Quigley, and T. D. Nguyen, “Biomechanics of the human posterior sclera: Age- and glaucoma-related changes measured using inflation testing,” Invest. Ophthalmol. Vis. Sci.53(4), 1714–1728 (2012).
[CrossRef] [PubMed]

2011

H. Yang, H. Thompson, M. D. Roberts, I. A. Sigal, J. C. Downs, and C. F. Burgoyne, “Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions,” Invest. Ophthalmol. Vis. Sci.52(1), 345–363 (2011).
[CrossRef] [PubMed]

M. J. A. Girard, J.-K. F. Suh, M. Bottlang, C. F. Burgoyne, and J. C. Downs, “Biomechanical changes in the sclera of monkey eyes exposed to chronic iop elevations,” Invest. Ophthalmol. Vis. Sci.52(8), 5656–5669 (2011).
[CrossRef] [PubMed]

Y. Lim, M. Yamanari, S. Fukuda, Y. Kaji, T. Kiuchi, M. Miura, T. Oshika, and Y. Yasuno, “Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(8), 2392–2402 (2011).
[CrossRef] [PubMed]

L. Duan, S. Makita, M. Yamanari, Y. Lim, and Y. Yasuno, “Monte-carlo-based phase retardation estimator for polarization sensitive optical coherence tomography,” Opt. Express19(17), 16330–16345 (2011).
[CrossRef] [PubMed]

S. Sakai, M. Yamanari, Y. Lim, N. Nakagawa, and Y. Yasuno, “In vivo evaluation of human skin anisotropy by polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(9), 2623–2631 (2011).
[CrossRef] [PubMed]

D. Yan, S. McPheeters, G. Johnson, U. Utzinger, and J. P. Vande Geest, “Microstructural differences in the human posterior sclera as a function of age and race,” Invest. Ophthalmol. Vis. Sci.52(2), 821–829 (2011).
[CrossRef] [PubMed]

M. J. A. Girard, A. Dahlmann-Noor, S. Rayapureddi, J. A. Bechara, B. M. E. Bertin, H. Jones, J. Albon, P. T. Khaw, and C. R. Ethier, “Quantitative mapping of scleral fiber orientation in normal rat eyes,” Invest. Ophthalmol. Vis. Sci.52(13), 9684–9693 (2011).
[CrossRef] [PubMed]

J. M. Bueno, E. J. Gualda, A. Giakoumaki, P. Pérez-Merino, S. Marcos, and P. Artal, “Multiphoton microscopy of ex vivo corneas after collagen cross-linking,” Invest. Ophthalmol. Vis. Sci.52(8), 5325–5331 (2011).
[CrossRef] [PubMed]

2010

S. Makita, M. Yamanari, and Y. Yasuno, “Generalized jones matrix optical coherence tomography: performance and local birefringence imaging,” Opt. Express18(2), 854–876 (2010).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, Y. Lim, and Y. Yasuno, “Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulation,” Opt. Express18(13), 13964–13980 (2010).
[CrossRef] [PubMed]

R. Grytz and G. Meschke, “A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shells,” Biomech. Model. Mechanobiol.9(2), 225–235 (2010).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, M. Miura, S. Fukuda, S. Makita, S. Sakai, and T. Oshika, “Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography,” J. Biomed. Opt.15(6), 061705 (2010).
[CrossRef] [PubMed]

2009

M. Miura, M. Yamanari, T. Iwasaki, M. Itoh, T. Yatagai, and Y. Yasuno, “Polarization-sensitive optical coherence tomography of necrotizing scleritis,” Ophthalmic Surg. Lasers Imaging40(6), 607–610 (2009).
[CrossRef] [PubMed]

S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, and P. Santi, “Porcine sclera as a model of human sclera for in vitro transport experiments: histology, sem, and comparative permeability,” Mol. Vis.15, 259–266 (2009).
[PubMed]

M. J. A. Girard, J. C. Downs, C. F. Burgoyne, and J.-K. F. Suh, “Peripapillary and posterior scleral mechanics--part i: Development of an anisotropic hyperelastic constitutive model,” J. Biomech. Eng.131(5), 051011 (2009).
[CrossRef] [PubMed]

M. C. van Turnhout, S. Kranenbarg, and J. L. van Leeuwen, “Modeling optical behavior of birefringent biological tissues for evaluation of quantitative polarized light microscopy,” J. Biomed. Opt.14(5), 054018 (2009).
[CrossRef] [PubMed]

A. Alm and S. F. Nilsson, “Uveoscleral outflow--a review,” Exp. Eye Res.88(4), 760–768 (2009).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express17(5), 3980–3996 (2009).
[CrossRef] [PubMed]

M. Yamanari, Y. Lim, S. Makita, and Y. Yasuno, “Visualization of phase retardation of deep posterior eye by polarization-sensitive swept-source optical coherence tomography with 1- µm probe,” Opt. Express17(15), 12385–12396 (2009).
[CrossRef] [PubMed]

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

2008

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express16(8), 5892–5906 (2008).
[CrossRef] [PubMed]

D. S. Schultz, J. C. Lotz, S. M. Lee, M. L. Trinidad, and J. M. Stewart, “Structural factors that mediate scleral stiffness,” Invest. Ophthalmol. Vis. Sci.49(10), 4232–4236 (2008).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt.13(1), 014013 (2008).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci.49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

2007

B. K. Pierscionek, M. Asejczyk-Widlicka, and R. A. Schachar, “The effect of changing intraocular pressure on the corneal and scleral curvatures in the fresh porcine eye,” Br. J. Ophthalmol.91(6), 801–803 (2007).
[CrossRef] [PubMed]

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
[CrossRef] [PubMed]

N. Morishige, A. J. Wahlert, M. C. Kenney, D. J. Brown, K. Kawamoto, T.-i. Chikama, T. Nishida, and J. V. Jester, “Second-harmonic imaging microscopy of normal human and keratoconus cornea,” Invest. Ophthalmol. Vis. Sci.48(3), 1087–1094 (2007).
[CrossRef] [PubMed]

2006

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

J. A. Rada, S. Shelton, and T. T. Norton, “The sclera and myopia,” Exp. Eye Res.82(2), 185–200 (2006).
[CrossRef] [PubMed]

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

2005

P. M. Pinsky, D. van der Heide, and D. Chernyak, “Computational modeling of mechanical anisotropy in the cornea and sclera,” J. Cataract Refract. Surg.31(1), 136–145 (2005).
[CrossRef] [PubMed]

C. F. Burgoyne, J. C. Downs, A. J. Bellezza, J. K. Suh, and R. T. Hart, “The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage,” Prog. Retin. Eye Res.24(1), 39–73 (2005).
[CrossRef] [PubMed]

J. C. Downs, J.-K. F. Suh, K. A. Thomas, A. J. Bellezza, R. T. Hart, and C. F. Burgoyne, “Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes,” Invest. Ophthalmol. Vis. Sci.46(2), 540–546 (2005).
[CrossRef] [PubMed]

J. Liu and C. J. Roberts, “Influence of corneal biomechanical properties on intraocular pressure measurement,” J. Cataract Refract. Surg.31(1), 146–155 (2005).
[CrossRef] [PubMed]

M. Han, G. Giese, and J. Bille, “Second harmonic generation imaging of collagen fibrils in cornea and sclera,” Opt. Express13(15), 5791–5797 (2005).
[CrossRef] [PubMed]

2004

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt.9(1), 94–102 (2004).
[CrossRef] [PubMed]

2003

A. J. Bellezza, C. J. Rintalan, H. W. Thompson, J. C. Downs, R. T. Hart, and C. F. Burgoyne, “Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma,” Invest. Ophthalmol. Vis. Sci.44(2), 623–637 (2003).
[CrossRef] [PubMed]

N. A. McBrien and A. Gentle, “Role of the sclera in the development and pathological complications of myopia,” Prog. Retin. Eye Res.22(3), 307–338 (2003).
[CrossRef] [PubMed]

2002

T. W. Olsen, S. Sanderson, X. Feng, and W. C. Hubbard, “Porcine sclera: Thickness and surface area,” Invest. Ophthalmol. Vis. Sci.43(8), 2529–2532 (2002).
[PubMed]

2001

N. A. McBrien, L. M. Cornell, and A. Gentle, “Structural and ultrastructural changes to the sclera in a mammalian model of high myopia,” Invest. Ophthalmol. Vis. Sci.42(10), 2179–2187 (2001).
[PubMed]

M. G. Ducros, J. D. Marsack, H. G. Rylander, S. L. Thomsen, and T. E. Milner, “Primate retina imaging with polarization-sensitive optical coherence tomography,” J. Opt. Soc. Am. A18(12), 2945–2956 (2001).
[CrossRef]

1999

J. T. Siegwart and T. T. Norton, “Regulation of the mechanical properties of tree shrew sclera by the visual environment,” Vision Res.39(2), 387–407 (1999).
[CrossRef] [PubMed]

1998

R. Oldenbourg, E. D. Salmon, and P. T. Tran, “Birefringence of single and bundled microtubules,” Biophys. J.74(1), 645–654 (1998).
[CrossRef] [PubMed]

Collaborative Normal-Tension Glaucoma Study Group, “Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures,” Am. J. Ophthalmol.126(4), 487–497 (1998).
[CrossRef] [PubMed]

R. H. Newton and K. M. Meek, “The integration of the corneal and limbal fibrils in the human eye,” Biophys. J.75(5), 2508–2512 (1998).
[CrossRef] [PubMed]

1997

G. D. Pins, D. L. Christiansen, R. Patel, and F. H. Silver, “Self-assembly of collagen fibers. influence of fibrillar alignment and decorin on mechanical properties,” Biophys. J.73(4), 2164–2172 (1997).
[CrossRef] [PubMed]

1991

H. A. Quigley, M. E. Dorman-Pease, and A. E. Brown, “Quantitative study of collagen and elastin of the optic nerve head and sclera in human and experimental monkey glaucoma,” Curr. Eye Res.10(9), 877–888 (1991).
[CrossRef] [PubMed]

1988

D. A. Parry, “The molecular and fibrillar structure of collagen and its relationship to the mechanical properties of connective tissue,” Biophys. Chem.29(1-2), 195–209 (1988).
[CrossRef] [PubMed]

1985

C. J. Doillon, M. G. Dunn, E. Bender, and F. H. Silver, “Collagen fiber formation in repair tissue: development of strength and toughness,” Coll. Relat. Res.5(6), 481–492 (1985).
[CrossRef] [PubMed]

1981

H. A. Quigley, E. M. Addicks, W. R. Green, and A. E. Maumenee, “Optic nerve damage in human glaucoma. Ii. the site of injury and susceptibility to damage,” Arch. Ophthalmol.99(4), 635–649 (1981).
[CrossRef] [PubMed]

Abe, H.

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Addicks, E. M.

H. A. Quigley, E. M. Addicks, W. R. Green, and A. E. Maumenee, “Optic nerve damage in human glaucoma. Ii. the site of injury and susceptibility to damage,” Arch. Ophthalmol.99(4), 635–649 (1981).
[CrossRef] [PubMed]

Albon, J.

M. J. A. Girard, A. Dahlmann-Noor, S. Rayapureddi, J. A. Bechara, B. M. E. Bertin, H. Jones, J. Albon, P. T. Khaw, and C. R. Ethier, “Quantitative mapping of scleral fiber orientation in normal rat eyes,” Invest. Ophthalmol. Vis. Sci.52(13), 9684–9693 (2011).
[CrossRef] [PubMed]

Alexander, S.

B. Coudrillier, J. Tian, S. Alexander, K. M. Myers, H. A. Quigley, and T. D. Nguyen, “Biomechanics of the human posterior sclera: Age- and glaucoma-related changes measured using inflation testing,” Invest. Ophthalmol. Vis. Sci.53(4), 1714–1728 (2012).
[CrossRef] [PubMed]

Alm, A.

A. Alm and S. F. Nilsson, “Uveoscleral outflow--a review,” Exp. Eye Res.88(4), 760–768 (2009).
[CrossRef] [PubMed]

Andersen, P.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

Araie, M.

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Artal, P.

J. M. Bueno, E. J. Gualda, A. Giakoumaki, P. Pérez-Merino, S. Marcos, and P. Artal, “Multiphoton microscopy of ex vivo corneas after collagen cross-linking,” Invest. Ophthalmol. Vis. Sci.52(8), 5325–5331 (2011).
[CrossRef] [PubMed]

Asejczyk-Widlicka, M.

B. K. Pierscionek, M. Asejczyk-Widlicka, and R. A. Schachar, “The effect of changing intraocular pressure on the corneal and scleral curvatures in the fresh porcine eye,” Br. J. Ophthalmol.91(6), 801–803 (2007).
[CrossRef] [PubMed]

Baumann, B.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

Bechara, J. A.

M. J. A. Girard, A. Dahlmann-Noor, S. Rayapureddi, J. A. Bechara, B. M. E. Bertin, H. Jones, J. Albon, P. T. Khaw, and C. R. Ethier, “Quantitative mapping of scleral fiber orientation in normal rat eyes,” Invest. Ophthalmol. Vis. Sci.52(13), 9684–9693 (2011).
[CrossRef] [PubMed]

Bellezza, A. J.

C. F. Burgoyne, J. C. Downs, A. J. Bellezza, J. K. Suh, and R. T. Hart, “The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage,” Prog. Retin. Eye Res.24(1), 39–73 (2005).
[CrossRef] [PubMed]

J. C. Downs, J.-K. F. Suh, K. A. Thomas, A. J. Bellezza, R. T. Hart, and C. F. Burgoyne, “Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes,” Invest. Ophthalmol. Vis. Sci.46(2), 540–546 (2005).
[CrossRef] [PubMed]

A. J. Bellezza, C. J. Rintalan, H. W. Thompson, J. C. Downs, R. T. Hart, and C. F. Burgoyne, “Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma,” Invest. Ophthalmol. Vis. Sci.44(2), 623–637 (2003).
[CrossRef] [PubMed]

Bender, E.

C. J. Doillon, M. G. Dunn, E. Bender, and F. H. Silver, “Collagen fiber formation in repair tissue: development of strength and toughness,” Coll. Relat. Res.5(6), 481–492 (1985).
[CrossRef] [PubMed]

Bertin, B. M. E.

M. J. A. Girard, A. Dahlmann-Noor, S. Rayapureddi, J. A. Bechara, B. M. E. Bertin, H. Jones, J. Albon, P. T. Khaw, and C. R. Ethier, “Quantitative mapping of scleral fiber orientation in normal rat eyes,” Invest. Ophthalmol. Vis. Sci.52(13), 9684–9693 (2011).
[CrossRef] [PubMed]

Biedermann, B.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

Bille, J.

Bonesi, M.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

T. Torzicky, M. Pircher, S. Zotter, M. Bonesi, E. Götzinger, and C. K. Hitzenberger, “Automated measurement of choroidal thickness in the human eye by polarization sensitive optical coherence tomography,” Opt. Express20(7), 7564–7574 (2012).
[CrossRef] [PubMed]

Boote, C.

B. Coudrillier, C. Boote, H. A. Quigley, and T. D. Nguyen, “Scleral anisotropy and its effects on the mechanical response of the optic nerve head,” Biomech. Model. Mechanobiol.12(5), 941–963 (2013).
[CrossRef] [PubMed]

J. K. Pijanka, B. Coudrillier, K. Ziegler, T. Sorensen, K. M. Meek, T. D. Nguyen, H. A. Quigley, and C. Boote, “Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae,” Invest. Ophthalmol. Vis. Sci.53(9), 5258–5270 (2012).
[CrossRef] [PubMed]

Bottlang, M.

M. J. A. Girard, J.-K. F. Suh, M. Bottlang, C. F. Burgoyne, and J. C. Downs, “Biomechanical changes in the sclera of monkey eyes exposed to chronic iop elevations,” Invest. Ophthalmol. Vis. Sci.52(8), 5656–5669 (2011).
[CrossRef] [PubMed]

Bouma, B. E.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
[CrossRef] [PubMed]

Bressner, J. E.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
[CrossRef] [PubMed]

Brown, A. E.

H. A. Quigley, M. E. Dorman-Pease, and A. E. Brown, “Quantitative study of collagen and elastin of the optic nerve head and sclera in human and experimental monkey glaucoma,” Curr. Eye Res.10(9), 877–888 (1991).
[CrossRef] [PubMed]

Brown, D. J.

N. Morishige, A. J. Wahlert, M. C. Kenney, D. J. Brown, K. Kawamoto, T.-i. Chikama, T. Nishida, and J. V. Jester, “Second-harmonic imaging microscopy of normal human and keratoconus cornea,” Invest. Ophthalmol. Vis. Sci.48(3), 1087–1094 (2007).
[CrossRef] [PubMed]

Bueno, J. M.

J. M. Bueno, E. J. Gualda, A. Giakoumaki, P. Pérez-Merino, S. Marcos, and P. Artal, “Multiphoton microscopy of ex vivo corneas after collagen cross-linking,” Invest. Ophthalmol. Vis. Sci.52(8), 5325–5331 (2011).
[CrossRef] [PubMed]

Burgoyne, C. F.

M. J. A. Girard, J.-K. F. Suh, M. Bottlang, C. F. Burgoyne, and J. C. Downs, “Biomechanical changes in the sclera of monkey eyes exposed to chronic iop elevations,” Invest. Ophthalmol. Vis. Sci.52(8), 5656–5669 (2011).
[CrossRef] [PubMed]

H. Yang, H. Thompson, M. D. Roberts, I. A. Sigal, J. C. Downs, and C. F. Burgoyne, “Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions,” Invest. Ophthalmol. Vis. Sci.52(1), 345–363 (2011).
[CrossRef] [PubMed]

M. J. A. Girard, J. C. Downs, C. F. Burgoyne, and J.-K. F. Suh, “Peripapillary and posterior scleral mechanics--part i: Development of an anisotropic hyperelastic constitutive model,” J. Biomech. Eng.131(5), 051011 (2009).
[CrossRef] [PubMed]

J. C. Downs, J.-K. F. Suh, K. A. Thomas, A. J. Bellezza, R. T. Hart, and C. F. Burgoyne, “Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes,” Invest. Ophthalmol. Vis. Sci.46(2), 540–546 (2005).
[CrossRef] [PubMed]

C. F. Burgoyne, J. C. Downs, A. J. Bellezza, J. K. Suh, and R. T. Hart, “The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage,” Prog. Retin. Eye Res.24(1), 39–73 (2005).
[CrossRef] [PubMed]

A. J. Bellezza, C. J. Rintalan, H. W. Thompson, J. C. Downs, R. T. Hart, and C. F. Burgoyne, “Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma,” Invest. Ophthalmol. Vis. Sci.44(2), 623–637 (2003).
[CrossRef] [PubMed]

Cense, B.

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

Chen, T. C.

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

Chernyak, D.

P. M. Pinsky, D. van der Heide, and D. Chernyak, “Computational modeling of mechanical anisotropy in the cornea and sclera,” J. Cataract Refract. Surg.31(1), 136–145 (2005).
[CrossRef] [PubMed]

Chikama, T.-i.

N. Morishige, A. J. Wahlert, M. C. Kenney, D. J. Brown, K. Kawamoto, T.-i. Chikama, T. Nishida, and J. V. Jester, “Second-harmonic imaging microscopy of normal human and keratoconus cornea,” Invest. Ophthalmol. Vis. Sci.48(3), 1087–1094 (2007).
[CrossRef] [PubMed]

Christiansen, D. L.

G. D. Pins, D. L. Christiansen, R. Patel, and F. H. Silver, “Self-assembly of collagen fibers. influence of fibrillar alignment and decorin on mechanical properties,” Biophys. J.73(4), 2164–2172 (1997).
[CrossRef] [PubMed]

Cornell, L. M.

N. A. McBrien, L. M. Cornell, and A. Gentle, “Structural and ultrastructural changes to the sclera in a mammalian model of high myopia,” Invest. Ophthalmol. Vis. Sci.42(10), 2179–2187 (2001).
[PubMed]

Coudrillier, B.

B. Coudrillier, C. Boote, H. A. Quigley, and T. D. Nguyen, “Scleral anisotropy and its effects on the mechanical response of the optic nerve head,” Biomech. Model. Mechanobiol.12(5), 941–963 (2013).
[CrossRef] [PubMed]

J. K. Pijanka, B. Coudrillier, K. Ziegler, T. Sorensen, K. M. Meek, T. D. Nguyen, H. A. Quigley, and C. Boote, “Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae,” Invest. Ophthalmol. Vis. Sci.53(9), 5258–5270 (2012).
[CrossRef] [PubMed]

B. Coudrillier, J. Tian, S. Alexander, K. M. Myers, H. A. Quigley, and T. D. Nguyen, “Biomechanics of the human posterior sclera: Age- and glaucoma-related changes measured using inflation testing,” Invest. Ophthalmol. Vis. Sci.53(4), 1714–1728 (2012).
[CrossRef] [PubMed]

Dahlmann-Noor, A.

M. J. A. Girard, A. Dahlmann-Noor, S. Rayapureddi, J. A. Bechara, B. M. E. Bertin, H. Jones, J. Albon, P. T. Khaw, and C. R. Ethier, “Quantitative mapping of scleral fiber orientation in normal rat eyes,” Invest. Ophthalmol. Vis. Sci.52(13), 9684–9693 (2011).
[CrossRef] [PubMed]

Dallatana, D.

S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, and P. Santi, “Porcine sclera as a model of human sclera for in vitro transport experiments: histology, sem, and comparative permeability,” Mol. Vis.15, 259–266 (2009).
[PubMed]

de Boer, J. F.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
[CrossRef] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

Doillon, C. J.

C. J. Doillon, M. G. Dunn, E. Bender, and F. H. Silver, “Collagen fiber formation in repair tissue: development of strength and toughness,” Coll. Relat. Res.5(6), 481–492 (1985).
[CrossRef] [PubMed]

Dong, C.-Y.

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

Dorman-Pease, M. E.

H. A. Quigley, M. E. Dorman-Pease, and A. E. Brown, “Quantitative study of collagen and elastin of the optic nerve head and sclera in human and experimental monkey glaucoma,” Curr. Eye Res.10(9), 877–888 (1991).
[CrossRef] [PubMed]

Downs, J. C.

H. Yang, H. Thompson, M. D. Roberts, I. A. Sigal, J. C. Downs, and C. F. Burgoyne, “Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions,” Invest. Ophthalmol. Vis. Sci.52(1), 345–363 (2011).
[CrossRef] [PubMed]

M. J. A. Girard, J.-K. F. Suh, M. Bottlang, C. F. Burgoyne, and J. C. Downs, “Biomechanical changes in the sclera of monkey eyes exposed to chronic iop elevations,” Invest. Ophthalmol. Vis. Sci.52(8), 5656–5669 (2011).
[CrossRef] [PubMed]

M. J. A. Girard, J. C. Downs, C. F. Burgoyne, and J.-K. F. Suh, “Peripapillary and posterior scleral mechanics--part i: Development of an anisotropic hyperelastic constitutive model,” J. Biomech. Eng.131(5), 051011 (2009).
[CrossRef] [PubMed]

J. C. Downs, J.-K. F. Suh, K. A. Thomas, A. J. Bellezza, R. T. Hart, and C. F. Burgoyne, “Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes,” Invest. Ophthalmol. Vis. Sci.46(2), 540–546 (2005).
[CrossRef] [PubMed]

C. F. Burgoyne, J. C. Downs, A. J. Bellezza, J. K. Suh, and R. T. Hart, “The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage,” Prog. Retin. Eye Res.24(1), 39–73 (2005).
[CrossRef] [PubMed]

A. J. Bellezza, C. J. Rintalan, H. W. Thompson, J. C. Downs, R. T. Hart, and C. F. Burgoyne, “Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma,” Invest. Ophthalmol. Vis. Sci.44(2), 623–637 (2003).
[CrossRef] [PubMed]

Duan, L.

Ducros, M. G.

Dunn, M. G.

C. J. Doillon, M. G. Dunn, E. Bender, and F. H. Silver, “Collagen fiber formation in repair tissue: development of strength and toughness,” Coll. Relat. Res.5(6), 481–492 (1985).
[CrossRef] [PubMed]

Elsner, A. E.

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci.49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

Ethier, C. R.

M. J. A. Girard, A. Dahlmann-Noor, S. Rayapureddi, J. A. Bechara, B. M. E. Bertin, H. Jones, J. Albon, P. T. Khaw, and C. R. Ethier, “Quantitative mapping of scleral fiber orientation in normal rat eyes,” Invest. Ophthalmol. Vis. Sci.52(13), 9684–9693 (2011).
[CrossRef] [PubMed]

Feng, X.

T. W. Olsen, S. Sanderson, X. Feng, and W. C. Hubbard, “Porcine sclera: Thickness and surface area,” Invest. Ophthalmol. Vis. Sci.43(8), 2529–2532 (2002).
[PubMed]

Fercher, A. F.

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt.9(1), 94–102 (2004).
[CrossRef] [PubMed]

Ferrari, G.

S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, and P. Santi, “Porcine sclera as a model of human sclera for in vitro transport experiments: histology, sem, and comparative permeability,” Mol. Vis.15, 259–266 (2009).
[PubMed]

Fukuda, S.

M. Yamanari, K. Ishii, S. Fukuda, Y. Lim, L. Duan, S. Makita, M. Miura, T. Oshika, and Y. Yasuno, “Optical rheology of porcine sclera by birefringence imaging,” PLoS ONE7(9), e44026 (2012).
[CrossRef] [PubMed]

Y. Lim, M. Yamanari, S. Fukuda, Y. Kaji, T. Kiuchi, M. Miura, T. Oshika, and Y. Yasuno, “Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(8), 2392–2402 (2011).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, M. Miura, S. Fukuda, S. Makita, S. Sakai, and T. Oshika, “Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography,” J. Biomed. Opt.15(6), 061705 (2010).
[CrossRef] [PubMed]

Gentle, A.

N. A. McBrien and A. Gentle, “Role of the sclera in the development and pathological complications of myopia,” Prog. Retin. Eye Res.22(3), 307–338 (2003).
[CrossRef] [PubMed]

N. A. McBrien, L. M. Cornell, and A. Gentle, “Structural and ultrastructural changes to the sclera in a mammalian model of high myopia,” Invest. Ophthalmol. Vis. Sci.42(10), 2179–2187 (2001).
[PubMed]

Giakoumaki, A.

J. M. Bueno, E. J. Gualda, A. Giakoumaki, P. Pérez-Merino, S. Marcos, and P. Artal, “Multiphoton microscopy of ex vivo corneas after collagen cross-linking,” Invest. Ophthalmol. Vis. Sci.52(8), 5325–5331 (2011).
[CrossRef] [PubMed]

Giese, G.

Girard, M. J. A.

M. J. A. Girard, J.-K. F. Suh, M. Bottlang, C. F. Burgoyne, and J. C. Downs, “Biomechanical changes in the sclera of monkey eyes exposed to chronic iop elevations,” Invest. Ophthalmol. Vis. Sci.52(8), 5656–5669 (2011).
[CrossRef] [PubMed]

M. J. A. Girard, A. Dahlmann-Noor, S. Rayapureddi, J. A. Bechara, B. M. E. Bertin, H. Jones, J. Albon, P. T. Khaw, and C. R. Ethier, “Quantitative mapping of scleral fiber orientation in normal rat eyes,” Invest. Ophthalmol. Vis. Sci.52(13), 9684–9693 (2011).
[CrossRef] [PubMed]

M. J. A. Girard, J. C. Downs, C. F. Burgoyne, and J.-K. F. Suh, “Peripapillary and posterior scleral mechanics--part i: Development of an anisotropic hyperelastic constitutive model,” J. Biomech. Eng.131(5), 051011 (2009).
[CrossRef] [PubMed]

Goto, H.

Götzinger, E.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

T. Torzicky, M. Pircher, S. Zotter, M. Bonesi, E. Götzinger, and C. K. Hitzenberger, “Automated measurement of choroidal thickness in the human eye by polarization sensitive optical coherence tomography,” Opt. Express20(7), 7564–7574 (2012).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt.9(1), 94–102 (2004).
[CrossRef] [PubMed]

Govoni, P.

S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, and P. Santi, “Porcine sclera as a model of human sclera for in vitro transport experiments: histology, sem, and comparative permeability,” Mol. Vis.15, 259–266 (2009).
[PubMed]

Green, W. R.

H. A. Quigley, E. M. Addicks, W. R. Green, and A. E. Maumenee, “Optic nerve damage in human glaucoma. Ii. the site of injury and susceptibility to damage,” Arch. Ophthalmol.99(4), 635–649 (1981).
[CrossRef] [PubMed]

Grytz, R.

R. Grytz and G. Meschke, “A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shells,” Biomech. Model. Mechanobiol.9(2), 225–235 (2010).
[CrossRef] [PubMed]

Gualda, E. J.

J. M. Bueno, E. J. Gualda, A. Giakoumaki, P. Pérez-Merino, S. Marcos, and P. Artal, “Multiphoton microscopy of ex vivo corneas after collagen cross-linking,” Invest. Ophthalmol. Vis. Sci.52(8), 5325–5331 (2011).
[CrossRef] [PubMed]

Halpern, E.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
[CrossRef] [PubMed]

Han, M.

Hart, R. T.

J. C. Downs, J.-K. F. Suh, K. A. Thomas, A. J. Bellezza, R. T. Hart, and C. F. Burgoyne, “Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes,” Invest. Ophthalmol. Vis. Sci.46(2), 540–546 (2005).
[CrossRef] [PubMed]

C. F. Burgoyne, J. C. Downs, A. J. Bellezza, J. K. Suh, and R. T. Hart, “The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage,” Prog. Retin. Eye Res.24(1), 39–73 (2005).
[CrossRef] [PubMed]

A. J. Bellezza, C. J. Rintalan, H. W. Thompson, J. C. Downs, R. T. Hart, and C. F. Burgoyne, “Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma,” Invest. Ophthalmol. Vis. Sci.44(2), 623–637 (2003).
[CrossRef] [PubMed]

Hitzenberger, C. K.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

T. Torzicky, M. Pircher, S. Zotter, M. Bonesi, E. Götzinger, and C. K. Hitzenberger, “Automated measurement of choroidal thickness in the human eye by polarization sensitive optical coherence tomography,” Opt. Express20(7), 7564–7574 (2012).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt.9(1), 94–102 (2004).
[CrossRef] [PubMed]

Hong, Y.-J.

Houser, S. L.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
[CrossRef] [PubMed]

Hubbard, W. C.

T. W. Olsen, S. Sanderson, X. Feng, and W. C. Hubbard, “Porcine sclera: Thickness and surface area,” Invest. Ophthalmol. Vis. Sci.43(8), 2529–2532 (2002).
[PubMed]

Huber, R.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

Inoue, Y.

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Ishii, K.

M. Yamanari, K. Ishii, S. Fukuda, Y. Lim, L. Duan, S. Makita, M. Miura, T. Oshika, and Y. Yasuno, “Optical rheology of porcine sclera by birefringence imaging,” PLoS ONE7(9), e44026 (2012).
[CrossRef] [PubMed]

Itoh, M.

M. Miura, M. Yamanari, T. Iwasaki, M. Itoh, T. Yatagai, and Y. Yasuno, “Polarization-sensitive optical coherence tomography of necrotizing scleritis,” Ophthalmic Surg. Lasers Imaging40(6), 607–610 (2009).
[CrossRef] [PubMed]

Iwasaki, T.

S. Nagase, M. Yamanari, R. Tanaka, T. Yasui, M. Miura, T. Iwasaki, H. Goto, and Y. Yasuno, “Anisotropic alteration of scleral birefringence to uniaxial mechanical strain,” PLoS ONE8(3), e58716 (2013).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, M. Itoh, T. Yatagai, and Y. Yasuno, “Polarization-sensitive optical coherence tomography of necrotizing scleritis,” Ophthalmic Surg. Lasers Imaging40(6), 607–610 (2009).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci.49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

Iwase, A.

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Iwaya, K.

Jee, S.-H.

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

Jester, J. V.

N. Morishige, A. J. Wahlert, M. C. Kenney, D. J. Brown, K. Kawamoto, T.-i. Chikama, T. Nishida, and J. V. Jester, “Second-harmonic imaging microscopy of normal human and keratoconus cornea,” Invest. Ophthalmol. Vis. Sci.48(3), 1087–1094 (2007).
[CrossRef] [PubMed]

Johnson, G.

D. Yan, S. McPheeters, G. Johnson, U. Utzinger, and J. P. Vande Geest, “Microstructural differences in the human posterior sclera as a function of age and race,” Invest. Ophthalmol. Vis. Sci.52(2), 821–829 (2011).
[CrossRef] [PubMed]

Jones, H.

M. J. A. Girard, A. Dahlmann-Noor, S. Rayapureddi, J. A. Bechara, B. M. E. Bertin, H. Jones, J. Albon, P. T. Khaw, and C. R. Ethier, “Quantitative mapping of scleral fiber orientation in normal rat eyes,” Invest. Ophthalmol. Vis. Sci.52(13), 9684–9693 (2011).
[CrossRef] [PubMed]

Kaji, Y.

Kawamoto, K.

N. Morishige, A. J. Wahlert, M. C. Kenney, D. J. Brown, K. Kawamoto, T.-i. Chikama, T. Nishida, and J. V. Jester, “Second-harmonic imaging microscopy of normal human and keratoconus cornea,” Invest. Ophthalmol. Vis. Sci.48(3), 1087–1094 (2007).
[CrossRef] [PubMed]

Kawana, K.

Kenney, M. C.

N. Morishige, A. J. Wahlert, M. C. Kenney, D. J. Brown, K. Kawamoto, T.-i. Chikama, T. Nishida, and J. V. Jester, “Second-harmonic imaging microscopy of normal human and keratoconus cornea,” Invest. Ophthalmol. Vis. Sci.48(3), 1087–1094 (2007).
[CrossRef] [PubMed]

Khaw, P. T.

M. J. A. Girard, A. Dahlmann-Noor, S. Rayapureddi, J. A. Bechara, B. M. E. Bertin, H. Jones, J. Albon, P. T. Khaw, and C. R. Ethier, “Quantitative mapping of scleral fiber orientation in normal rat eyes,” Invest. Ophthalmol. Vis. Sci.52(13), 9684–9693 (2011).
[CrossRef] [PubMed]

Kim, K. H.

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

Kimura, K.

N. Morishige, N. Yamada, X. Zhang, Y. Morita, N. Yamada, K. Kimura, A. Takahara, and K.-H. Sonoda, “Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy,” Invest. Ophthalmol. Vis. Sci.53(8), 4998–5003 (2012).
[CrossRef] [PubMed]

Kitazawa, Y.

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Kiuchi, T.

Klein, T.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

Kranenbarg, S.

M. C. van Turnhout, S. Kranenbarg, and J. L. van Leeuwen, “Modeling optical behavior of birefringent biological tissues for evaluation of quantitative polarized light microscopy,” J. Biomed. Opt.14(5), 054018 (2009).
[CrossRef] [PubMed]

Kuwayama, Y.

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Lee, S. M.

D. S. Schultz, J. C. Lotz, S. M. Lee, M. L. Trinidad, and J. M. Stewart, “Structural factors that mediate scleral stiffness,” Invest. Ophthalmol. Vis. Sci.49(10), 4232–4236 (2008).
[CrossRef] [PubMed]

Lim, Y.

M. Yamanari, K. Ishii, S. Fukuda, Y. Lim, L. Duan, S. Makita, M. Miura, T. Oshika, and Y. Yasuno, “Optical rheology of porcine sclera by birefringence imaging,” PLoS ONE7(9), e44026 (2012).
[CrossRef] [PubMed]

Y. Lim, Y.-J. Hong, L. Duan, M. Yamanari, and Y. Yasuno, “Passive component based multifunctional jones matrix swept source optical coherence tomography for doppler and polarization imaging,” Opt. Lett.37(11), 1958–1960 (2012).
[CrossRef] [PubMed]

L. Duan, S. Makita, M. Yamanari, Y. Lim, and Y. Yasuno, “Monte-carlo-based phase retardation estimator for polarization sensitive optical coherence tomography,” Opt. Express19(17), 16330–16345 (2011).
[CrossRef] [PubMed]

S. Sakai, M. Yamanari, Y. Lim, N. Nakagawa, and Y. Yasuno, “In vivo evaluation of human skin anisotropy by polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(9), 2623–2631 (2011).
[CrossRef] [PubMed]

Y. Lim, M. Yamanari, S. Fukuda, Y. Kaji, T. Kiuchi, M. Miura, T. Oshika, and Y. Yasuno, “Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(8), 2392–2402 (2011).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, Y. Lim, and Y. Yasuno, “Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulation,” Opt. Express18(13), 13964–13980 (2010).
[CrossRef] [PubMed]

M. Yamanari, Y. Lim, S. Makita, and Y. Yasuno, “Visualization of phase retardation of deep posterior eye by polarization-sensitive swept-source optical coherence tomography with 1- µm probe,” Opt. Express17(15), 12385–12396 (2009).
[CrossRef] [PubMed]

Lin, H.-H.

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

Lin, S.-J.

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

Lin, W.-C.

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

Liu, J.

J. Liu and C. J. Roberts, “Influence of corneal biomechanical properties on intraocular pressure measurement,” J. Cataract Refract. Surg.31(1), 146–155 (2005).
[CrossRef] [PubMed]

Lo, W.

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

Lotz, J. C.

D. S. Schultz, J. C. Lotz, S. M. Lee, M. L. Trinidad, and J. M. Stewart, “Structural factors that mediate scleral stiffness,” Invest. Ophthalmol. Vis. Sci.49(10), 4232–4236 (2008).
[CrossRef] [PubMed]

Macaluso, C.

S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, and P. Santi, “Porcine sclera as a model of human sclera for in vitro transport experiments: histology, sem, and comparative permeability,” Mol. Vis.15, 259–266 (2009).
[PubMed]

Makita, S.

M. Yamanari, K. Ishii, S. Fukuda, Y. Lim, L. Duan, S. Makita, M. Miura, T. Oshika, and Y. Yasuno, “Optical rheology of porcine sclera by birefringence imaging,” PLoS ONE7(9), e44026 (2012).
[CrossRef] [PubMed]

L. Duan, S. Makita, M. Yamanari, Y. Lim, and Y. Yasuno, “Monte-carlo-based phase retardation estimator for polarization sensitive optical coherence tomography,” Opt. Express19(17), 16330–16345 (2011).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, Y. Lim, and Y. Yasuno, “Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulation,” Opt. Express18(13), 13964–13980 (2010).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, M. Miura, S. Fukuda, S. Makita, S. Sakai, and T. Oshika, “Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography,” J. Biomed. Opt.15(6), 061705 (2010).
[CrossRef] [PubMed]

S. Makita, M. Yamanari, and Y. Yasuno, “Generalized jones matrix optical coherence tomography: performance and local birefringence imaging,” Opt. Express18(2), 854–876 (2010).
[CrossRef] [PubMed]

M. Yamanari, Y. Lim, S. Makita, and Y. Yasuno, “Visualization of phase retardation of deep posterior eye by polarization-sensitive swept-source optical coherence tomography with 1- µm probe,” Opt. Express17(15), 12385–12396 (2009).
[CrossRef] [PubMed]

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci.49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express16(8), 5892–5906 (2008).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt.13(1), 014013 (2008).
[CrossRef] [PubMed]

Marcos, S.

J. M. Bueno, E. J. Gualda, A. Giakoumaki, P. Pérez-Merino, S. Marcos, and P. Artal, “Multiphoton microscopy of ex vivo corneas after collagen cross-linking,” Invest. Ophthalmol. Vis. Sci.52(8), 5325–5331 (2011).
[CrossRef] [PubMed]

Marsack, J. D.

Marschall, S.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

Maumenee, A. E.

H. A. Quigley, E. M. Addicks, W. R. Green, and A. E. Maumenee, “Optic nerve damage in human glaucoma. Ii. the site of injury and susceptibility to damage,” Arch. Ophthalmol.99(4), 635–649 (1981).
[CrossRef] [PubMed]

McBrien, N. A.

N. A. McBrien and A. Gentle, “Role of the sclera in the development and pathological complications of myopia,” Prog. Retin. Eye Res.22(3), 307–338 (2003).
[CrossRef] [PubMed]

N. A. McBrien, L. M. Cornell, and A. Gentle, “Structural and ultrastructural changes to the sclera in a mammalian model of high myopia,” Invest. Ophthalmol. Vis. Sci.42(10), 2179–2187 (2001).
[PubMed]

McPheeters, S.

D. Yan, S. McPheeters, G. Johnson, U. Utzinger, and J. P. Vande Geest, “Microstructural differences in the human posterior sclera as a function of age and race,” Invest. Ophthalmol. Vis. Sci.52(2), 821–829 (2011).
[CrossRef] [PubMed]

Meek, K. M.

J. K. Pijanka, B. Coudrillier, K. Ziegler, T. Sorensen, K. M. Meek, T. D. Nguyen, H. A. Quigley, and C. Boote, “Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae,” Invest. Ophthalmol. Vis. Sci.53(9), 5258–5270 (2012).
[CrossRef] [PubMed]

R. H. Newton and K. M. Meek, “The integration of the corneal and limbal fibrils in the human eye,” Biophys. J.75(5), 2508–2512 (1998).
[CrossRef] [PubMed]

Meschke, G.

R. Grytz and G. Meschke, “A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shells,” Biomech. Model. Mechanobiol.9(2), 225–235 (2010).
[CrossRef] [PubMed]

Milner, T. E.

Mishima, H. K.

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Miura, M.

S. Nagase, M. Yamanari, R. Tanaka, T. Yasui, M. Miura, T. Iwasaki, H. Goto, and Y. Yasuno, “Anisotropic alteration of scleral birefringence to uniaxial mechanical strain,” PLoS ONE8(3), e58716 (2013).
[CrossRef] [PubMed]

M. Yamanari, K. Ishii, S. Fukuda, Y. Lim, L. Duan, S. Makita, M. Miura, T. Oshika, and Y. Yasuno, “Optical rheology of porcine sclera by birefringence imaging,” PLoS ONE7(9), e44026 (2012).
[CrossRef] [PubMed]

Y. Lim, M. Yamanari, S. Fukuda, Y. Kaji, T. Kiuchi, M. Miura, T. Oshika, and Y. Yasuno, “Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(8), 2392–2402 (2011).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, M. Miura, S. Fukuda, S. Makita, S. Sakai, and T. Oshika, “Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography,” J. Biomed. Opt.15(6), 061705 (2010).
[CrossRef] [PubMed]

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, M. Itoh, T. Yatagai, and Y. Yasuno, “Polarization-sensitive optical coherence tomography of necrotizing scleritis,” Ophthalmic Surg. Lasers Imaging40(6), 607–610 (2009).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express17(5), 3980–3996 (2009).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt.13(1), 014013 (2008).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci.49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

Miyazawa, A.

Morishige, N.

N. Morishige, N. Yamada, X. Zhang, Y. Morita, N. Yamada, K. Kimura, A. Takahara, and K.-H. Sonoda, “Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy,” Invest. Ophthalmol. Vis. Sci.53(8), 4998–5003 (2012).
[CrossRef] [PubMed]

N. Morishige, A. J. Wahlert, M. C. Kenney, D. J. Brown, K. Kawamoto, T.-i. Chikama, T. Nishida, and J. V. Jester, “Second-harmonic imaging microscopy of normal human and keratoconus cornea,” Invest. Ophthalmol. Vis. Sci.48(3), 1087–1094 (2007).
[CrossRef] [PubMed]

Morita, Y.

N. Morishige, N. Yamada, X. Zhang, Y. Morita, N. Yamada, K. Kimura, A. Takahara, and K.-H. Sonoda, “Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy,” Invest. Ophthalmol. Vis. Sci.53(8), 4998–5003 (2012).
[CrossRef] [PubMed]

Myers, K. M.

B. Coudrillier, J. Tian, S. Alexander, K. M. Myers, H. A. Quigley, and T. D. Nguyen, “Biomechanics of the human posterior sclera: Age- and glaucoma-related changes measured using inflation testing,” Invest. Ophthalmol. Vis. Sci.53(4), 1714–1728 (2012).
[CrossRef] [PubMed]

Nadkarni, S. K.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
[CrossRef] [PubMed]

Nagase, S.

S. Nagase, M. Yamanari, R. Tanaka, T. Yasui, M. Miura, T. Iwasaki, H. Goto, and Y. Yasuno, “Anisotropic alteration of scleral birefringence to uniaxial mechanical strain,” PLoS ONE8(3), e58716 (2013).
[CrossRef] [PubMed]

Nakagawa, N.

Newton, R. H.

R. H. Newton and K. M. Meek, “The integration of the corneal and limbal fibrils in the human eye,” Biophys. J.75(5), 2508–2512 (1998).
[CrossRef] [PubMed]

Nguyen, T. D.

B. Coudrillier, C. Boote, H. A. Quigley, and T. D. Nguyen, “Scleral anisotropy and its effects on the mechanical response of the optic nerve head,” Biomech. Model. Mechanobiol.12(5), 941–963 (2013).
[CrossRef] [PubMed]

J. K. Pijanka, B. Coudrillier, K. Ziegler, T. Sorensen, K. M. Meek, T. D. Nguyen, H. A. Quigley, and C. Boote, “Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae,” Invest. Ophthalmol. Vis. Sci.53(9), 5258–5270 (2012).
[CrossRef] [PubMed]

B. Coudrillier, J. Tian, S. Alexander, K. M. Myers, H. A. Quigley, and T. D. Nguyen, “Biomechanics of the human posterior sclera: Age- and glaucoma-related changes measured using inflation testing,” Invest. Ophthalmol. Vis. Sci.53(4), 1714–1728 (2012).
[CrossRef] [PubMed]

Nicoli, S.

S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, and P. Santi, “Porcine sclera as a model of human sclera for in vitro transport experiments: histology, sem, and comparative permeability,” Mol. Vis.15, 259–266 (2009).
[PubMed]

Nilsson, S. F.

A. Alm and S. F. Nilsson, “Uveoscleral outflow--a review,” Exp. Eye Res.88(4), 760–768 (2009).
[CrossRef] [PubMed]

Nishida, T.

N. Morishige, A. J. Wahlert, M. C. Kenney, D. J. Brown, K. Kawamoto, T.-i. Chikama, T. Nishida, and J. V. Jester, “Second-harmonic imaging microscopy of normal human and keratoconus cornea,” Invest. Ophthalmol. Vis. Sci.48(3), 1087–1094 (2007).
[CrossRef] [PubMed]

Norton, T. T.

J. A. Rada, S. Shelton, and T. T. Norton, “The sclera and myopia,” Exp. Eye Res.82(2), 185–200 (2006).
[CrossRef] [PubMed]

J. T. Siegwart and T. T. Norton, “Regulation of the mechanical properties of tree shrew sclera by the visual environment,” Vision Res.39(2), 387–407 (1999).
[CrossRef] [PubMed]

Oldenbourg, R.

R. Oldenbourg, E. D. Salmon, and P. T. Tran, “Birefringence of single and bundled microtubules,” Biophys. J.74(1), 645–654 (1998).
[CrossRef] [PubMed]

Olsen, T. W.

T. W. Olsen, S. Sanderson, X. Feng, and W. C. Hubbard, “Porcine sclera: Thickness and surface area,” Invest. Ophthalmol. Vis. Sci.43(8), 2529–2532 (2002).
[PubMed]

Oshika, T.

M. Yamanari, K. Ishii, S. Fukuda, Y. Lim, L. Duan, S. Makita, M. Miura, T. Oshika, and Y. Yasuno, “Optical rheology of porcine sclera by birefringence imaging,” PLoS ONE7(9), e44026 (2012).
[CrossRef] [PubMed]

Y. Lim, M. Yamanari, S. Fukuda, Y. Kaji, T. Kiuchi, M. Miura, T. Oshika, and Y. Yasuno, “Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(8), 2392–2402 (2011).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, M. Miura, S. Fukuda, S. Makita, S. Sakai, and T. Oshika, “Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography,” J. Biomed. Opt.15(6), 061705 (2010).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express17(5), 3980–3996 (2009).
[CrossRef] [PubMed]

Park, B. H.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
[CrossRef] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

Parry, D. A.

D. A. Parry, “The molecular and fibrillar structure of collagen and its relationship to the mechanical properties of connective tissue,” Biophys. Chem.29(1-2), 195–209 (1988).
[CrossRef] [PubMed]

Patel, R.

G. D. Pins, D. L. Christiansen, R. Patel, and F. H. Silver, “Self-assembly of collagen fibers. influence of fibrillar alignment and decorin on mechanical properties,” Biophys. J.73(4), 2164–2172 (1997).
[CrossRef] [PubMed]

Peng, J.-L.

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

Pérez-Merino, P.

J. M. Bueno, E. J. Gualda, A. Giakoumaki, P. Pérez-Merino, S. Marcos, and P. Artal, “Multiphoton microscopy of ex vivo corneas after collagen cross-linking,” Invest. Ophthalmol. Vis. Sci.52(8), 5325–5331 (2011).
[CrossRef] [PubMed]

Pierce, M. C.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
[CrossRef] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

Pierscionek, B. K.

B. K. Pierscionek, M. Asejczyk-Widlicka, and R. A. Schachar, “The effect of changing intraocular pressure on the corneal and scleral curvatures in the fresh porcine eye,” Br. J. Ophthalmol.91(6), 801–803 (2007).
[CrossRef] [PubMed]

Pijanka, J. K.

J. K. Pijanka, B. Coudrillier, K. Ziegler, T. Sorensen, K. M. Meek, T. D. Nguyen, H. A. Quigley, and C. Boote, “Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae,” Invest. Ophthalmol. Vis. Sci.53(9), 5258–5270 (2012).
[CrossRef] [PubMed]

Pins, G. D.

G. D. Pins, D. L. Christiansen, R. Patel, and F. H. Silver, “Self-assembly of collagen fibers. influence of fibrillar alignment and decorin on mechanical properties,” Biophys. J.73(4), 2164–2172 (1997).
[CrossRef] [PubMed]

Pinsky, P. M.

P. M. Pinsky, D. van der Heide, and D. Chernyak, “Computational modeling of mechanical anisotropy in the cornea and sclera,” J. Cataract Refract. Surg.31(1), 136–145 (2005).
[CrossRef] [PubMed]

Pircher, M.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

T. Torzicky, M. Pircher, S. Zotter, M. Bonesi, E. Götzinger, and C. K. Hitzenberger, “Automated measurement of choroidal thickness in the human eye by polarization sensitive optical coherence tomography,” Opt. Express20(7), 7564–7574 (2012).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt.9(1), 94–102 (2004).
[CrossRef] [PubMed]

Quarta, M.

S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, and P. Santi, “Porcine sclera as a model of human sclera for in vitro transport experiments: histology, sem, and comparative permeability,” Mol. Vis.15, 259–266 (2009).
[PubMed]

Quigley, H. A.

B. Coudrillier, C. Boote, H. A. Quigley, and T. D. Nguyen, “Scleral anisotropy and its effects on the mechanical response of the optic nerve head,” Biomech. Model. Mechanobiol.12(5), 941–963 (2013).
[CrossRef] [PubMed]

J. K. Pijanka, B. Coudrillier, K. Ziegler, T. Sorensen, K. M. Meek, T. D. Nguyen, H. A. Quigley, and C. Boote, “Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae,” Invest. Ophthalmol. Vis. Sci.53(9), 5258–5270 (2012).
[CrossRef] [PubMed]

B. Coudrillier, J. Tian, S. Alexander, K. M. Myers, H. A. Quigley, and T. D. Nguyen, “Biomechanics of the human posterior sclera: Age- and glaucoma-related changes measured using inflation testing,” Invest. Ophthalmol. Vis. Sci.53(4), 1714–1728 (2012).
[CrossRef] [PubMed]

H. A. Quigley, M. E. Dorman-Pease, and A. E. Brown, “Quantitative study of collagen and elastin of the optic nerve head and sclera in human and experimental monkey glaucoma,” Curr. Eye Res.10(9), 877–888 (1991).
[CrossRef] [PubMed]

H. A. Quigley, E. M. Addicks, W. R. Green, and A. E. Maumenee, “Optic nerve damage in human glaucoma. Ii. the site of injury and susceptibility to damage,” Arch. Ophthalmol.99(4), 635–649 (1981).
[CrossRef] [PubMed]

Rada, J. A.

J. A. Rada, S. Shelton, and T. T. Norton, “The sclera and myopia,” Exp. Eye Res.82(2), 185–200 (2006).
[CrossRef] [PubMed]

Rayapureddi, S.

M. J. A. Girard, A. Dahlmann-Noor, S. Rayapureddi, J. A. Bechara, B. M. E. Bertin, H. Jones, J. Albon, P. T. Khaw, and C. R. Ethier, “Quantitative mapping of scleral fiber orientation in normal rat eyes,” Invest. Ophthalmol. Vis. Sci.52(13), 9684–9693 (2011).
[CrossRef] [PubMed]

Rintalan, C. J.

A. J. Bellezza, C. J. Rintalan, H. W. Thompson, J. C. Downs, R. T. Hart, and C. F. Burgoyne, “Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma,” Invest. Ophthalmol. Vis. Sci.44(2), 623–637 (2003).
[CrossRef] [PubMed]

Roberts, C. J.

J. Liu and C. J. Roberts, “Influence of corneal biomechanical properties on intraocular pressure measurement,” J. Cataract Refract. Surg.31(1), 146–155 (2005).
[CrossRef] [PubMed]

Roberts, M. D.

H. Yang, H. Thompson, M. D. Roberts, I. A. Sigal, J. C. Downs, and C. F. Burgoyne, “Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions,” Invest. Ophthalmol. Vis. Sci.52(1), 345–363 (2011).
[CrossRef] [PubMed]

Rylander, H. G.

Sakai, S.

S. Sakai, M. Yamanari, Y. Lim, N. Nakagawa, and Y. Yasuno, “In vivo evaluation of human skin anisotropy by polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(9), 2623–2631 (2011).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, M. Miura, S. Fukuda, S. Makita, S. Sakai, and T. Oshika, “Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography,” J. Biomed. Opt.15(6), 061705 (2010).
[CrossRef] [PubMed]

Salmon, E. D.

R. Oldenbourg, E. D. Salmon, and P. T. Tran, “Birefringence of single and bundled microtubules,” Biophys. J.74(1), 645–654 (1998).
[CrossRef] [PubMed]

Sanderson, S.

T. W. Olsen, S. Sanderson, X. Feng, and W. C. Hubbard, “Porcine sclera: Thickness and surface area,” Invest. Ophthalmol. Vis. Sci.43(8), 2529–2532 (2002).
[PubMed]

Santi, P.

S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, and P. Santi, “Porcine sclera as a model of human sclera for in vitro transport experiments: histology, sem, and comparative permeability,” Mol. Vis.15, 259–266 (2009).
[PubMed]

Schachar, R. A.

B. K. Pierscionek, M. Asejczyk-Widlicka, and R. A. Schachar, “The effect of changing intraocular pressure on the corneal and scleral curvatures in the fresh porcine eye,” Br. J. Ophthalmol.91(6), 801–803 (2007).
[CrossRef] [PubMed]

Schultz, D. S.

D. S. Schultz, J. C. Lotz, S. M. Lee, M. L. Trinidad, and J. M. Stewart, “Structural factors that mediate scleral stiffness,” Invest. Ophthalmol. Vis. Sci.49(10), 4232–4236 (2008).
[CrossRef] [PubMed]

Shelton, S.

J. A. Rada, S. Shelton, and T. T. Norton, “The sclera and myopia,” Exp. Eye Res.82(2), 185–200 (2006).
[CrossRef] [PubMed]

Shimizu, H.

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Shirato, S.

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Siegwart, J. T.

J. T. Siegwart and T. T. Norton, “Regulation of the mechanical properties of tree shrew sclera by the visual environment,” Vision Res.39(2), 387–407 (1999).
[CrossRef] [PubMed]

Sigal, I. A.

H. Yang, H. Thompson, M. D. Roberts, I. A. Sigal, J. C. Downs, and C. F. Burgoyne, “Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions,” Invest. Ophthalmol. Vis. Sci.52(1), 345–363 (2011).
[CrossRef] [PubMed]

Silver, F. H.

G. D. Pins, D. L. Christiansen, R. Patel, and F. H. Silver, “Self-assembly of collagen fibers. influence of fibrillar alignment and decorin on mechanical properties,” Biophys. J.73(4), 2164–2172 (1997).
[CrossRef] [PubMed]

C. J. Doillon, M. G. Dunn, E. Bender, and F. H. Silver, “Collagen fiber formation in repair tissue: development of strength and toughness,” Coll. Relat. Res.5(6), 481–492 (1985).
[CrossRef] [PubMed]

So, P. T. C.

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

Sonoda, K.-H.

N. Morishige, N. Yamada, X. Zhang, Y. Morita, N. Yamada, K. Kimura, A. Takahara, and K.-H. Sonoda, “Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy,” Invest. Ophthalmol. Vis. Sci.53(8), 4998–5003 (2012).
[CrossRef] [PubMed]

Sorensen, T.

J. K. Pijanka, B. Coudrillier, K. Ziegler, T. Sorensen, K. M. Meek, T. D. Nguyen, H. A. Quigley, and C. Boote, “Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae,” Invest. Ophthalmol. Vis. Sci.53(9), 5258–5270 (2012).
[CrossRef] [PubMed]

Stewart, J. M.

D. S. Schultz, J. C. Lotz, S. M. Lee, M. L. Trinidad, and J. M. Stewart, “Structural factors that mediate scleral stiffness,” Invest. Ophthalmol. Vis. Sci.49(10), 4232–4236 (2008).
[CrossRef] [PubMed]

Sticker, M.

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt.9(1), 94–102 (2004).
[CrossRef] [PubMed]

Suh, J. K.

C. F. Burgoyne, J. C. Downs, A. J. Bellezza, J. K. Suh, and R. T. Hart, “The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage,” Prog. Retin. Eye Res.24(1), 39–73 (2005).
[CrossRef] [PubMed]

Suh, J.-K. F.

M. J. A. Girard, J.-K. F. Suh, M. Bottlang, C. F. Burgoyne, and J. C. Downs, “Biomechanical changes in the sclera of monkey eyes exposed to chronic iop elevations,” Invest. Ophthalmol. Vis. Sci.52(8), 5656–5669 (2011).
[CrossRef] [PubMed]

M. J. A. Girard, J. C. Downs, C. F. Burgoyne, and J.-K. F. Suh, “Peripapillary and posterior scleral mechanics--part i: Development of an anisotropic hyperelastic constitutive model,” J. Biomech. Eng.131(5), 051011 (2009).
[CrossRef] [PubMed]

J. C. Downs, J.-K. F. Suh, K. A. Thomas, A. J. Bellezza, R. T. Hart, and C. F. Burgoyne, “Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes,” Invest. Ophthalmol. Vis. Sci.46(2), 540–546 (2005).
[CrossRef] [PubMed]

Sun, Y.

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

Suzuki, Y.

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Takahara, A.

N. Morishige, N. Yamada, X. Zhang, Y. Morita, N. Yamada, K. Kimura, A. Takahara, and K.-H. Sonoda, “Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy,” Invest. Ophthalmol. Vis. Sci.53(8), 4998–5003 (2012).
[CrossRef] [PubMed]

Tan, H.-Y.

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

Tanaka, R.

S. Nagase, M. Yamanari, R. Tanaka, T. Yasui, M. Miura, T. Iwasaki, H. Goto, and Y. Yasuno, “Anisotropic alteration of scleral birefringence to uniaxial mechanical strain,” PLoS ONE8(3), e58716 (2013).
[CrossRef] [PubMed]

Tearney, G. J.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
[CrossRef] [PubMed]

Teng, S.-W.

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

Thomas, K. A.

J. C. Downs, J.-K. F. Suh, K. A. Thomas, A. J. Bellezza, R. T. Hart, and C. F. Burgoyne, “Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes,” Invest. Ophthalmol. Vis. Sci.46(2), 540–546 (2005).
[CrossRef] [PubMed]

Thompson, H.

H. Yang, H. Thompson, M. D. Roberts, I. A. Sigal, J. C. Downs, and C. F. Burgoyne, “Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions,” Invest. Ophthalmol. Vis. Sci.52(1), 345–363 (2011).
[CrossRef] [PubMed]

Thompson, H. W.

A. J. Bellezza, C. J. Rintalan, H. W. Thompson, J. C. Downs, R. T. Hart, and C. F. Burgoyne, “Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma,” Invest. Ophthalmol. Vis. Sci.44(2), 623–637 (2003).
[CrossRef] [PubMed]

Thomsen, S. L.

Tian, J.

B. Coudrillier, J. Tian, S. Alexander, K. M. Myers, H. A. Quigley, and T. D. Nguyen, “Biomechanics of the human posterior sclera: Age- and glaucoma-related changes measured using inflation testing,” Invest. Ophthalmol. Vis. Sci.53(4), 1714–1728 (2012).
[CrossRef] [PubMed]

Tomita, G.

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Torzicky, T.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

T. Torzicky, M. Pircher, S. Zotter, M. Bonesi, E. Götzinger, and C. K. Hitzenberger, “Automated measurement of choroidal thickness in the human eye by polarization sensitive optical coherence tomography,” Opt. Express20(7), 7564–7574 (2012).
[CrossRef] [PubMed]

Tran, P. T.

R. Oldenbourg, E. D. Salmon, and P. T. Tran, “Birefringence of single and bundled microtubules,” Biophys. J.74(1), 645–654 (1998).
[CrossRef] [PubMed]

Trasischker, W.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

Trinidad, M. L.

D. S. Schultz, J. C. Lotz, S. M. Lee, M. L. Trinidad, and J. M. Stewart, “Structural factors that mediate scleral stiffness,” Invest. Ophthalmol. Vis. Sci.49(10), 4232–4236 (2008).
[CrossRef] [PubMed]

Utzinger, U.

D. Yan, S. McPheeters, G. Johnson, U. Utzinger, and J. P. Vande Geest, “Microstructural differences in the human posterior sclera as a function of age and race,” Invest. Ophthalmol. Vis. Sci.52(2), 821–829 (2011).
[CrossRef] [PubMed]

van der Heide, D.

P. M. Pinsky, D. van der Heide, and D. Chernyak, “Computational modeling of mechanical anisotropy in the cornea and sclera,” J. Cataract Refract. Surg.31(1), 136–145 (2005).
[CrossRef] [PubMed]

van Leeuwen, J. L.

M. C. van Turnhout, S. Kranenbarg, and J. L. van Leeuwen, “Modeling optical behavior of birefringent biological tissues for evaluation of quantitative polarized light microscopy,” J. Biomed. Opt.14(5), 054018 (2009).
[CrossRef] [PubMed]

van Turnhout, M. C.

M. C. van Turnhout, S. Kranenbarg, and J. L. van Leeuwen, “Modeling optical behavior of birefringent biological tissues for evaluation of quantitative polarized light microscopy,” J. Biomed. Opt.14(5), 054018 (2009).
[CrossRef] [PubMed]

Vande Geest, J. P.

D. Yan, S. McPheeters, G. Johnson, U. Utzinger, and J. P. Vande Geest, “Microstructural differences in the human posterior sclera as a function of age and race,” Invest. Ophthalmol. Vis. Sci.52(2), 821–829 (2011).
[CrossRef] [PubMed]

Wahlert, A. J.

N. Morishige, A. J. Wahlert, M. C. Kenney, D. J. Brown, K. Kawamoto, T.-i. Chikama, T. Nishida, and J. V. Jester, “Second-harmonic imaging microscopy of normal human and keratoconus cornea,” Invest. Ophthalmol. Vis. Sci.48(3), 1087–1094 (2007).
[CrossRef] [PubMed]

Whittaker, P.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
[CrossRef] [PubMed]

Wieser, W.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

Yamada, N.

N. Morishige, N. Yamada, X. Zhang, Y. Morita, N. Yamada, K. Kimura, A. Takahara, and K.-H. Sonoda, “Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy,” Invest. Ophthalmol. Vis. Sci.53(8), 4998–5003 (2012).
[CrossRef] [PubMed]

N. Morishige, N. Yamada, X. Zhang, Y. Morita, N. Yamada, K. Kimura, A. Takahara, and K.-H. Sonoda, “Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy,” Invest. Ophthalmol. Vis. Sci.53(8), 4998–5003 (2012).
[CrossRef] [PubMed]

Yamamoto, T.

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Yamanari, M.

S. Nagase, M. Yamanari, R. Tanaka, T. Yasui, M. Miura, T. Iwasaki, H. Goto, and Y. Yasuno, “Anisotropic alteration of scleral birefringence to uniaxial mechanical strain,” PLoS ONE8(3), e58716 (2013).
[CrossRef] [PubMed]

Y. Lim, Y.-J. Hong, L. Duan, M. Yamanari, and Y. Yasuno, “Passive component based multifunctional jones matrix swept source optical coherence tomography for doppler and polarization imaging,” Opt. Lett.37(11), 1958–1960 (2012).
[CrossRef] [PubMed]

L. Duan, M. Yamanari, and Y. Yasuno, “Automated phase retardation oriented segmentation of chorio-scleral interface by polarization sensitive optical coherence tomography,” Opt. Express20(3), 3353–3366 (2012).
[CrossRef] [PubMed]

M. Yamanari, K. Ishii, S. Fukuda, Y. Lim, L. Duan, S. Makita, M. Miura, T. Oshika, and Y. Yasuno, “Optical rheology of porcine sclera by birefringence imaging,” PLoS ONE7(9), e44026 (2012).
[CrossRef] [PubMed]

S. Sakai, M. Yamanari, Y. Lim, N. Nakagawa, and Y. Yasuno, “In vivo evaluation of human skin anisotropy by polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(9), 2623–2631 (2011).
[CrossRef] [PubMed]

Y. Lim, M. Yamanari, S. Fukuda, Y. Kaji, T. Kiuchi, M. Miura, T. Oshika, and Y. Yasuno, “Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(8), 2392–2402 (2011).
[CrossRef] [PubMed]

L. Duan, S. Makita, M. Yamanari, Y. Lim, and Y. Yasuno, “Monte-carlo-based phase retardation estimator for polarization sensitive optical coherence tomography,” Opt. Express19(17), 16330–16345 (2011).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, Y. Lim, and Y. Yasuno, “Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulation,” Opt. Express18(13), 13964–13980 (2010).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, M. Miura, S. Fukuda, S. Makita, S. Sakai, and T. Oshika, “Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography,” J. Biomed. Opt.15(6), 061705 (2010).
[CrossRef] [PubMed]

S. Makita, M. Yamanari, and Y. Yasuno, “Generalized jones matrix optical coherence tomography: performance and local birefringence imaging,” Opt. Express18(2), 854–876 (2010).
[CrossRef] [PubMed]

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

M. Yamanari, Y. Lim, S. Makita, and Y. Yasuno, “Visualization of phase retardation of deep posterior eye by polarization-sensitive swept-source optical coherence tomography with 1- µm probe,” Opt. Express17(15), 12385–12396 (2009).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, M. Itoh, T. Yatagai, and Y. Yasuno, “Polarization-sensitive optical coherence tomography of necrotizing scleritis,” Ophthalmic Surg. Lasers Imaging40(6), 607–610 (2009).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express17(5), 3980–3996 (2009).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express16(8), 5892–5906 (2008).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt.13(1), 014013 (2008).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci.49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

Yan, D.

D. Yan, S. McPheeters, G. Johnson, U. Utzinger, and J. P. Vande Geest, “Microstructural differences in the human posterior sclera as a function of age and race,” Invest. Ophthalmol. Vis. Sci.52(2), 821–829 (2011).
[CrossRef] [PubMed]

Yang, H.

H. Yang, H. Thompson, M. D. Roberts, I. A. Sigal, J. C. Downs, and C. F. Burgoyne, “Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions,” Invest. Ophthalmol. Vis. Sci.52(1), 345–363 (2011).
[CrossRef] [PubMed]

Yasui, T.

S. Nagase, M. Yamanari, R. Tanaka, T. Yasui, M. Miura, T. Iwasaki, H. Goto, and Y. Yasuno, “Anisotropic alteration of scleral birefringence to uniaxial mechanical strain,” PLoS ONE8(3), e58716 (2013).
[CrossRef] [PubMed]

Yasuno, Y.

S. Nagase, M. Yamanari, R. Tanaka, T. Yasui, M. Miura, T. Iwasaki, H. Goto, and Y. Yasuno, “Anisotropic alteration of scleral birefringence to uniaxial mechanical strain,” PLoS ONE8(3), e58716 (2013).
[CrossRef] [PubMed]

Y. Lim, Y.-J. Hong, L. Duan, M. Yamanari, and Y. Yasuno, “Passive component based multifunctional jones matrix swept source optical coherence tomography for doppler and polarization imaging,” Opt. Lett.37(11), 1958–1960 (2012).
[CrossRef] [PubMed]

L. Duan, M. Yamanari, and Y. Yasuno, “Automated phase retardation oriented segmentation of chorio-scleral interface by polarization sensitive optical coherence tomography,” Opt. Express20(3), 3353–3366 (2012).
[CrossRef] [PubMed]

M. Yamanari, K. Ishii, S. Fukuda, Y. Lim, L. Duan, S. Makita, M. Miura, T. Oshika, and Y. Yasuno, “Optical rheology of porcine sclera by birefringence imaging,” PLoS ONE7(9), e44026 (2012).
[CrossRef] [PubMed]

S. Sakai, M. Yamanari, Y. Lim, N. Nakagawa, and Y. Yasuno, “In vivo evaluation of human skin anisotropy by polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(9), 2623–2631 (2011).
[CrossRef] [PubMed]

Y. Lim, M. Yamanari, S. Fukuda, Y. Kaji, T. Kiuchi, M. Miura, T. Oshika, and Y. Yasuno, “Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography,” Biomed. Opt. Express2(8), 2392–2402 (2011).
[CrossRef] [PubMed]

L. Duan, S. Makita, M. Yamanari, Y. Lim, and Y. Yasuno, “Monte-carlo-based phase retardation estimator for polarization sensitive optical coherence tomography,” Opt. Express19(17), 16330–16345 (2011).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, Y. Lim, and Y. Yasuno, “Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulation,” Opt. Express18(13), 13964–13980 (2010).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, M. Miura, S. Fukuda, S. Makita, S. Sakai, and T. Oshika, “Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography,” J. Biomed. Opt.15(6), 061705 (2010).
[CrossRef] [PubMed]

S. Makita, M. Yamanari, and Y. Yasuno, “Generalized jones matrix optical coherence tomography: performance and local birefringence imaging,” Opt. Express18(2), 854–876 (2010).
[CrossRef] [PubMed]

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

M. Yamanari, Y. Lim, S. Makita, and Y. Yasuno, “Visualization of phase retardation of deep posterior eye by polarization-sensitive swept-source optical coherence tomography with 1- µm probe,” Opt. Express17(15), 12385–12396 (2009).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, M. Itoh, T. Yatagai, and Y. Yasuno, “Polarization-sensitive optical coherence tomography of necrotizing scleritis,” Ophthalmic Surg. Lasers Imaging40(6), 607–610 (2009).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express17(5), 3980–3996 (2009).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express16(8), 5892–5906 (2008).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt.13(1), 014013 (2008).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci.49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

Yatagai, T.

M. Miura, M. Yamanari, T. Iwasaki, M. Itoh, T. Yatagai, and Y. Yasuno, “Polarization-sensitive optical coherence tomography of necrotizing scleritis,” Ophthalmic Surg. Lasers Imaging40(6), 607–610 (2009).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci.49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt.13(1), 014013 (2008).
[CrossRef] [PubMed]

Zhang, X.

N. Morishige, N. Yamada, X. Zhang, Y. Morita, N. Yamada, K. Kimura, A. Takahara, and K.-H. Sonoda, “Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy,” Invest. Ophthalmol. Vis. Sci.53(8), 4998–5003 (2012).
[CrossRef] [PubMed]

Ziegler, K.

J. K. Pijanka, B. Coudrillier, K. Ziegler, T. Sorensen, K. M. Meek, T. D. Nguyen, H. A. Quigley, and C. Boote, “Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae,” Invest. Ophthalmol. Vis. Sci.53(9), 5258–5270 (2012).
[CrossRef] [PubMed]

Zotter, S.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

T. Torzicky, M. Pircher, S. Zotter, M. Bonesi, E. Götzinger, and C. K. Hitzenberger, “Automated measurement of choroidal thickness in the human eye by polarization sensitive optical coherence tomography,” Opt. Express20(7), 7564–7574 (2012).
[CrossRef] [PubMed]

Am. J. Ophthalmol.

Collaborative Normal-Tension Glaucoma Study Group, “Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures,” Am. J. Ophthalmol.126(4), 487–497 (1998).
[CrossRef] [PubMed]

Arch. Ophthalmol.

H. A. Quigley, E. M. Addicks, W. R. Green, and A. E. Maumenee, “Optic nerve damage in human glaucoma. Ii. the site of injury and susceptibility to damage,” Arch. Ophthalmol.99(4), 635–649 (1981).
[CrossRef] [PubMed]

Biomech. Model. Mechanobiol.

R. Grytz and G. Meschke, “A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shells,” Biomech. Model. Mechanobiol.9(2), 225–235 (2010).
[CrossRef] [PubMed]

B. Coudrillier, C. Boote, H. A. Quigley, and T. D. Nguyen, “Scleral anisotropy and its effects on the mechanical response of the optic nerve head,” Biomech. Model. Mechanobiol.12(5), 941–963 (2013).
[CrossRef] [PubMed]

Biomed. Opt. Express

Biophys. Chem.

D. A. Parry, “The molecular and fibrillar structure of collagen and its relationship to the mechanical properties of connective tissue,” Biophys. Chem.29(1-2), 195–209 (1988).
[CrossRef] [PubMed]

Biophys. J.

G. D. Pins, D. L. Christiansen, R. Patel, and F. H. Silver, “Self-assembly of collagen fibers. influence of fibrillar alignment and decorin on mechanical properties,” Biophys. J.73(4), 2164–2172 (1997).
[CrossRef] [PubMed]

R. Oldenbourg, E. D. Salmon, and P. T. Tran, “Birefringence of single and bundled microtubules,” Biophys. J.74(1), 645–654 (1998).
[CrossRef] [PubMed]

R. H. Newton and K. M. Meek, “The integration of the corneal and limbal fibrils in the human eye,” Biophys. J.75(5), 2508–2512 (1998).
[CrossRef] [PubMed]

Br. J. Ophthalmol.

B. K. Pierscionek, M. Asejczyk-Widlicka, and R. A. Schachar, “The effect of changing intraocular pressure on the corneal and scleral curvatures in the fresh porcine eye,” Br. J. Ophthalmol.91(6), 801–803 (2007).
[CrossRef] [PubMed]

Coll. Relat. Res.

C. J. Doillon, M. G. Dunn, E. Bender, and F. H. Silver, “Collagen fiber formation in repair tissue: development of strength and toughness,” Coll. Relat. Res.5(6), 481–492 (1985).
[CrossRef] [PubMed]

Curr. Eye Res.

H. A. Quigley, M. E. Dorman-Pease, and A. E. Brown, “Quantitative study of collagen and elastin of the optic nerve head and sclera in human and experimental monkey glaucoma,” Curr. Eye Res.10(9), 877–888 (1991).
[CrossRef] [PubMed]

Exp. Eye Res.

J. A. Rada, S. Shelton, and T. T. Norton, “The sclera and myopia,” Exp. Eye Res.82(2), 185–200 (2006).
[CrossRef] [PubMed]

A. Alm and S. F. Nilsson, “Uveoscleral outflow--a review,” Exp. Eye Res.88(4), 760–768 (2009).
[CrossRef] [PubMed]

Invest. Ophthalmol. Vis. Sci.

D. Yan, S. McPheeters, G. Johnson, U. Utzinger, and J. P. Vande Geest, “Microstructural differences in the human posterior sclera as a function of age and race,” Invest. Ophthalmol. Vis. Sci.52(2), 821–829 (2011).
[CrossRef] [PubMed]

M. J. A. Girard, A. Dahlmann-Noor, S. Rayapureddi, J. A. Bechara, B. M. E. Bertin, H. Jones, J. Albon, P. T. Khaw, and C. R. Ethier, “Quantitative mapping of scleral fiber orientation in normal rat eyes,” Invest. Ophthalmol. Vis. Sci.52(13), 9684–9693 (2011).
[CrossRef] [PubMed]

N. Morishige, A. J. Wahlert, M. C. Kenney, D. J. Brown, K. Kawamoto, T.-i. Chikama, T. Nishida, and J. V. Jester, “Second-harmonic imaging microscopy of normal human and keratoconus cornea,” Invest. Ophthalmol. Vis. Sci.48(3), 1087–1094 (2007).
[CrossRef] [PubMed]

J. M. Bueno, E. J. Gualda, A. Giakoumaki, P. Pérez-Merino, S. Marcos, and P. Artal, “Multiphoton microscopy of ex vivo corneas after collagen cross-linking,” Invest. Ophthalmol. Vis. Sci.52(8), 5325–5331 (2011).
[CrossRef] [PubMed]

N. Morishige, N. Yamada, X. Zhang, Y. Morita, N. Yamada, K. Kimura, A. Takahara, and K.-H. Sonoda, “Abnormalities of stromal structure in the bullous keratopathy cornea identified by second harmonic generation imaging microscopy,” Invest. Ophthalmol. Vis. Sci.53(8), 4998–5003 (2012).
[CrossRef] [PubMed]

S.-W. Teng, H.-Y. Tan, J.-L. Peng, H.-H. Lin, K. H. Kim, W. Lo, Y. Sun, W.-C. Lin, S.-J. Lin, S.-H. Jee, P. T. C. So, and C.-Y. Dong, “Multiphoton autofluorescence and second-harmonic generation imaging of the ex vivo porcine eye,” Invest. Ophthalmol. Vis. Sci.47(3), 1216–1224 (2006).
[CrossRef] [PubMed]

N. A. McBrien, L. M. Cornell, and A. Gentle, “Structural and ultrastructural changes to the sclera in a mammalian model of high myopia,” Invest. Ophthalmol. Vis. Sci.42(10), 2179–2187 (2001).
[PubMed]

J. K. Pijanka, B. Coudrillier, K. Ziegler, T. Sorensen, K. M. Meek, T. D. Nguyen, H. A. Quigley, and C. Boote, “Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae,” Invest. Ophthalmol. Vis. Sci.53(9), 5258–5270 (2012).
[CrossRef] [PubMed]

J. C. Downs, J.-K. F. Suh, K. A. Thomas, A. J. Bellezza, R. T. Hart, and C. F. Burgoyne, “Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes,” Invest. Ophthalmol. Vis. Sci.46(2), 540–546 (2005).
[CrossRef] [PubMed]

B. Coudrillier, J. Tian, S. Alexander, K. M. Myers, H. A. Quigley, and T. D. Nguyen, “Biomechanics of the human posterior sclera: Age- and glaucoma-related changes measured using inflation testing,” Invest. Ophthalmol. Vis. Sci.53(4), 1714–1728 (2012).
[CrossRef] [PubMed]

A. J. Bellezza, C. J. Rintalan, H. W. Thompson, J. C. Downs, R. T. Hart, and C. F. Burgoyne, “Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma,” Invest. Ophthalmol. Vis. Sci.44(2), 623–637 (2003).
[CrossRef] [PubMed]

H. Yang, H. Thompson, M. D. Roberts, I. A. Sigal, J. C. Downs, and C. F. Burgoyne, “Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions,” Invest. Ophthalmol. Vis. Sci.52(1), 345–363 (2011).
[CrossRef] [PubMed]

T. W. Olsen, S. Sanderson, X. Feng, and W. C. Hubbard, “Porcine sclera: Thickness and surface area,” Invest. Ophthalmol. Vis. Sci.43(8), 2529–2532 (2002).
[PubMed]

D. S. Schultz, J. C. Lotz, S. M. Lee, M. L. Trinidad, and J. M. Stewart, “Structural factors that mediate scleral stiffness,” Invest. Ophthalmol. Vis. Sci.49(10), 4232–4236 (2008).
[CrossRef] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci.49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

M. J. A. Girard, J.-K. F. Suh, M. Bottlang, C. F. Burgoyne, and J. C. Downs, “Biomechanical changes in the sclera of monkey eyes exposed to chronic iop elevations,” Invest. Ophthalmol. Vis. Sci.52(8), 5656–5669 (2011).
[CrossRef] [PubMed]

J. Am. Coll. Cardiol.

S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney, “Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography,” J. Am. Coll. Cardiol.49(13), 1474–1481 (2007).
[CrossRef] [PubMed]

J. Biomech. Eng.

M. J. A. Girard, J. C. Downs, C. F. Burgoyne, and J.-K. F. Suh, “Peripapillary and posterior scleral mechanics--part i: Development of an anisotropic hyperelastic constitutive model,” J. Biomech. Eng.131(5), 051011 (2009).
[CrossRef] [PubMed]

J. Biomed. Opt.

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt.13(1), 014013 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt.9(1), 94–102 (2004).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, M. Miura, S. Fukuda, S. Makita, S. Sakai, and T. Oshika, “Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography,” J. Biomed. Opt.15(6), 061705 (2010).
[CrossRef] [PubMed]

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 khz a-scan rate using an fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

M. C. van Turnhout, S. Kranenbarg, and J. L. van Leeuwen, “Modeling optical behavior of birefringent biological tissues for evaluation of quantitative polarized light microscopy,” J. Biomed. Opt.14(5), 054018 (2009).
[CrossRef] [PubMed]

J. Cataract Refract. Surg.

J. Liu and C. J. Roberts, “Influence of corneal biomechanical properties on intraocular pressure measurement,” J. Cataract Refract. Surg.31(1), 146–155 (2005).
[CrossRef] [PubMed]

P. M. Pinsky, D. van der Heide, and D. Chernyak, “Computational modeling of mechanical anisotropy in the cornea and sclera,” J. Cataract Refract. Surg.31(1), 136–145 (2005).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A

Mol. Vis.

S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, and P. Santi, “Porcine sclera as a model of human sclera for in vitro transport experiments: histology, sem, and comparative permeability,” Mol. Vis.15, 259–266 (2009).
[PubMed]

Ophthalmic Surg. Lasers Imaging

M. Miura, M. Yamanari, T. Iwasaki, M. Itoh, T. Yatagai, and Y. Yasuno, “Polarization-sensitive optical coherence tomography of necrotizing scleritis,” Ophthalmic Surg. Lasers Imaging40(6), 607–610 (2009).
[CrossRef] [PubMed]

Ophthalmology

Y. Suzuki, A. Iwase, M. Araie, T. Yamamoto, H. Abe, S. Shirato, Y. Kuwayama, H. K. Mishima, H. Shimizu, G. Tomita, Y. Inoue, Y. Kitazawa, and Tajimi Study Group, “Risk factors for open-angle glaucoma in a japanese population: The tajimi study,” Ophthalmology113(9), 1613–1617 (2006).
[CrossRef] [PubMed]

Opt. Express

M. Han, G. Giese, and J. Bille, “Second harmonic generation imaging of collagen fibrils in cornea and sclera,” Opt. Express13(15), 5791–5797 (2005).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express16(8), 5892–5906 (2008).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express17(5), 3980–3996 (2009).
[CrossRef] [PubMed]

M. Yamanari, Y. Lim, S. Makita, and Y. Yasuno, “Visualization of phase retardation of deep posterior eye by polarization-sensitive swept-source optical coherence tomography with 1- µm probe,” Opt. Express17(15), 12385–12396 (2009).
[CrossRef] [PubMed]

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

S. Makita, M. Yamanari, and Y. Yasuno, “Generalized jones matrix optical coherence tomography: performance and local birefringence imaging,” Opt. Express18(2), 854–876 (2010).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, Y. Lim, and Y. Yasuno, “Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulation,” Opt. Express18(13), 13964–13980 (2010).
[CrossRef] [PubMed]

L. Duan, S. Makita, M. Yamanari, Y. Lim, and Y. Yasuno, “Monte-carlo-based phase retardation estimator for polarization sensitive optical coherence tomography,” Opt. Express19(17), 16330–16345 (2011).
[CrossRef] [PubMed]

L. Duan, M. Yamanari, and Y. Yasuno, “Automated phase retardation oriented segmentation of chorio-scleral interface by polarization sensitive optical coherence tomography,” Opt. Express20(3), 3353–3366 (2012).
[CrossRef] [PubMed]

T. Torzicky, M. Pircher, S. Zotter, M. Bonesi, E. Götzinger, and C. K. Hitzenberger, “Automated measurement of choroidal thickness in the human eye by polarization sensitive optical coherence tomography,” Opt. Express20(7), 7564–7574 (2012).
[CrossRef] [PubMed]

Opt. Lett.

PLoS ONE

S. Nagase, M. Yamanari, R. Tanaka, T. Yasui, M. Miura, T. Iwasaki, H. Goto, and Y. Yasuno, “Anisotropic alteration of scleral birefringence to uniaxial mechanical strain,” PLoS ONE8(3), e58716 (2013).
[CrossRef] [PubMed]

M. Yamanari, K. Ishii, S. Fukuda, Y. Lim, L. Duan, S. Makita, M. Miura, T. Oshika, and Y. Yasuno, “Optical rheology of porcine sclera by birefringence imaging,” PLoS ONE7(9), e44026 (2012).
[CrossRef] [PubMed]

Prog. Retin. Eye Res.

N. A. McBrien and A. Gentle, “Role of the sclera in the development and pathological complications of myopia,” Prog. Retin. Eye Res.22(3), 307–338 (2003).
[CrossRef] [PubMed]

C. F. Burgoyne, J. C. Downs, A. J. Bellezza, J. K. Suh, and R. T. Hart, “The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage,” Prog. Retin. Eye Res.24(1), 39–73 (2005).
[CrossRef] [PubMed]

Vision Res.

J. T. Siegwart and T. T. Norton, “Regulation of the mechanical properties of tree shrew sclera by the visual environment,” Vision Res.39(2), 387–407 (1999).
[CrossRef] [PubMed]

Other

M. J. Hogan, J. A. Alvarado, and J. E. Weddell, Histology of the human eye: an atlas and textbook (Saunders, 1971).

P. Watson and B. Hazleman, The Sclera and Systemic Disorders (Jp Medical Pub, 2012).

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (8)

Fig. 1
Fig. 1

Representative OCT intensity (a) and local birefringence (b) images of human sclera in vivo. Red outlined areas show the extracted region used to calculate averaged birefringence in each sample. Scale bar represents 500 μm × 500 μm.

Fig. 2
Fig. 2

Schematic of the experiment designed to measure the inflation response of scleral birefringence.

Fig. 3
Fig. 3

Representative OCT intensity (a) and local birefringence (b) images of porcine sclera ex vivo. Red outlined areas show the extracted region used to calculate averaged birefringence in each sample. Scale bar represents 500 μm × 500 μm.

Fig. 4
Fig. 4

Plots of local birefringence of the human sclera and spherical equivalent (a), axial eye length (b), and IOP (c).

Fig. 5
Fig. 5

Plots of local birefringence of the porcine sclera and controlled IOP. Linear regression line of each porcine eye is also shown. Each color represents a different eye.

Fig. 6
Fig. 6

Scatter plot of the slope between scleral birefringence and IOP. Filled square and open squares show the results of in vivo human eyes and ex vivo porcine eyes, respectively.

Fig. 7
Fig. 7

SHG microscopy images of the porcine sclera at the superior side of the cornea. Rows A, B, and C show the SHG images on the external surface, at the depth of 600 μm, and on the internal surface of the sclera, respectively. The numbers of the columns from 1 to 6 show IDs of porcine eyes.

Fig. 8
Fig. 8

SHG images of the porcine sclera at the posterior pole. Rows A, B, and C show the SHG images on the external surface, at the depth of 600 μm, and on the internal surface of the sclera, respectively. The numbers of the columns from 1 to 6 show IDs of porcine eyes.

Metrics