Abstract

Angle-resolved low coherence interferometry (a/LCI) is an approach for assessing tissue structure based on light scattering data. Recent advances in a/LCI have extended the analysis to study scattering distributions in two dimensions. In order to provide suitable scattering phantoms for 2D a/LCI, we have developed phantoms based on soft lithography which can provide a range of structures including long range order. Here we characterize these phantoms and demonstrate their utility for providing standardized multi-scale structural information for light scattering measurements.

© 2013 OSA

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  1. A. Wax, C. H. Yang, V. Backman, K. Badizadegan, C. W. Boone, R. R. Dasari, and M. S. Feld, “Cellular organization and substructure measured using angle-resolved low-coherence interferometry,” Biophys. J.82(4), 2256–2264 (2002).
    [CrossRef] [PubMed]
  2. Y. Zhu, N. G. Terry, J. T. Woosley, N. J. Shaheen, and A. Wax, “Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology,” J. Biomed. Opt.16(1), 011003 (2011).
    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  4. J. W. Pyhtila, K. J. Chalut, J. D. Boyer, J. Keener, T. D’Amico, M. Gottfried, F. Gress, and A. Wax, “In situ detection of nuclear atypia in Barrett’s esophagus by using angle-resolved low-coherence interferometry,” Gastrointest. Endosc.65(3), 487–491 (2007).
    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]

2012 (1)

2011 (3)

Y. Zhu, N. G. Terry, J. T. Woosley, N. J. Shaheen, and A. Wax, “Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology,” J. Biomed. Opt.16(1), 011003 (2011).
[CrossRef] [PubMed]

N. Terry, Y. Zhu, J. K. M. Thacker, J. Migaly, C. Guy, C. R. Mantyh, and A. Wax, “Detection of intestinal dysplasia using angle-resolved low coherence interferometry,” J. Biomed. Opt.16(10), 106002 (2011).
[CrossRef] [PubMed]

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

2010 (2)

2007 (1)

J. W. Pyhtila, K. J. Chalut, J. D. Boyer, J. Keener, T. D’Amico, M. Gottfried, F. Gress, and A. Wax, “In situ detection of nuclear atypia in Barrett’s esophagus by using angle-resolved low-coherence interferometry,” Gastrointest. Endosc.65(3), 487–491 (2007).
[CrossRef] [PubMed]

2006 (1)

J. W. Pyhtila, H. Ma, A. J. Simnick, A. Chilkoti, and A. Wax, “Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry,” J. Biomed. Opt.11(3), 034022 (2006).
[CrossRef] [PubMed]

2005 (1)

2002 (1)

A. Wax, C. H. Yang, V. Backman, K. Badizadegan, C. W. Boone, R. R. Dasari, and M. S. Feld, “Cellular organization and substructure measured using angle-resolved low-coherence interferometry,” Biophys. J.82(4), 2256–2264 (2002).
[CrossRef] [PubMed]

1997 (1)

1991 (1)

Agrawal, A.

Backman, V.

Y. L. Kim, Y. Liu, R. K. Wali, H. K. Roy, and V. Backman, “Low-coherent backscattering spectroscopy for tissue characterization,” Appl. Opt.44(3), 366–377 (2005).
[CrossRef] [PubMed]

A. Wax, C. H. Yang, V. Backman, K. Badizadegan, C. W. Boone, R. R. Dasari, and M. S. Feld, “Cellular organization and substructure measured using angle-resolved low-coherence interferometry,” Biophys. J.82(4), 2256–2264 (2002).
[CrossRef] [PubMed]

Badizadegan, K.

A. Wax, C. H. Yang, V. Backman, K. Badizadegan, C. W. Boone, R. R. Dasari, and M. S. Feld, “Cellular organization and substructure measured using angle-resolved low-coherence interferometry,” Biophys. J.82(4), 2256–2264 (2002).
[CrossRef] [PubMed]

Bennett, A.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Bigio, I. J.

Boone, C. W.

A. Wax, C. H. Yang, V. Backman, K. Badizadegan, C. W. Boone, R. R. Dasari, and M. S. Feld, “Cellular organization and substructure measured using angle-resolved low-coherence interferometry,” Biophys. J.82(4), 2256–2264 (2002).
[CrossRef] [PubMed]

Boyer, J.

Boyer, J. D.

J. W. Pyhtila, K. J. Chalut, J. D. Boyer, J. Keener, T. D’Amico, M. Gottfried, F. Gress, and A. Wax, “In situ detection of nuclear atypia in Barrett’s esophagus by using angle-resolved low-coherence interferometry,” Gastrointest. Endosc.65(3), 487–491 (2007).
[CrossRef] [PubMed]

Bright, S.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Brown, W. J.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Carretta, E.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Chalut, K. J.

J. W. Pyhtila, K. J. Chalut, J. D. Boyer, J. Keener, T. D’Amico, M. Gottfried, F. Gress, and A. Wax, “In situ detection of nuclear atypia in Barrett’s esophagus by using angle-resolved low-coherence interferometry,” Gastrointest. Endosc.65(3), 487–491 (2007).
[CrossRef] [PubMed]

Chen, Y.

Chilkoti, A.

J. W. Pyhtila, H. Ma, A. J. Simnick, A. Chilkoti, and A. Wax, “Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry,” J. Biomed. Opt.11(3), 034022 (2006).
[CrossRef] [PubMed]

D’Amico, T.

J. W. Pyhtila, K. J. Chalut, J. D. Boyer, J. Keener, T. D’Amico, M. Gottfried, F. Gress, and A. Wax, “In situ detection of nuclear atypia in Barrett’s esophagus by using angle-resolved low-coherence interferometry,” Gastrointest. Endosc.65(3), 487–491 (2007).
[CrossRef] [PubMed]

Dasari, R. R.

A. Wax, C. H. Yang, V. Backman, K. Badizadegan, C. W. Boone, R. R. Dasari, and M. S. Feld, “Cellular organization and substructure measured using angle-resolved low-coherence interferometry,” Biophys. J.82(4), 2256–2264 (2002).
[CrossRef] [PubMed]

Dellon, E. S.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Drezek, R.

Feld, M. S.

A. Wax, C. H. Yang, V. Backman, K. Badizadegan, C. W. Boone, R. R. Dasari, and M. S. Feld, “Cellular organization and substructure measured using angle-resolved low-coherence interferometry,” Biophys. J.82(4), 2256–2264 (2002).
[CrossRef] [PubMed]

Fuselier, T.

Galanko, J.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Gebhart, S. C.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Giacomelli, M.

Gilani, N.

Goldblum, J. R.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Gottfried, M.

J. W. Pyhtila, K. J. Chalut, J. D. Boyer, J. Keener, T. D’Amico, M. Gottfried, F. Gress, and A. Wax, “In situ detection of nuclear atypia in Barrett’s esophagus by using angle-resolved low-coherence interferometry,” Gastrointest. Endosc.65(3), 487–491 (2007).
[CrossRef] [PubMed]

Gress, F.

J. W. Pyhtila, K. J. Chalut, J. D. Boyer, J. Keener, T. D’Amico, M. Gottfried, F. Gress, and A. Wax, “In situ detection of nuclear atypia in Barrett’s esophagus by using angle-resolved low-coherence interferometry,” Gastrointest. Endosc.65(3), 487–491 (2007).
[CrossRef] [PubMed]

Guy, C.

N. Terry, Y. Zhu, J. K. M. Thacker, J. Migaly, C. Guy, C. R. Mantyh, and A. Wax, “Detection of intestinal dysplasia using angle-resolved low coherence interferometry,” J. Biomed. Opt.16(10), 106002 (2011).
[CrossRef] [PubMed]

Johnson, T. M.

Keener, J.

J. W. Pyhtila, K. J. Chalut, J. D. Boyer, J. Keener, T. D’Amico, M. Gottfried, F. Gress, and A. Wax, “In situ detection of nuclear atypia in Barrett’s esophagus by using angle-resolved low-coherence interferometry,” Gastrointest. Endosc.65(3), 487–491 (2007).
[CrossRef] [PubMed]

Kim, Y. L.

Lee, J.

Liu, J. T. C.

Liu, Y.

Ma, H.

J. W. Pyhtila, H. Ma, A. J. Simnick, A. Chilkoti, and A. Wax, “Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry,” J. Biomed. Opt.11(3), 034022 (2006).
[CrossRef] [PubMed]

Madanick, R. D.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Mantyh, C. R.

N. Terry, Y. Zhu, J. K. M. Thacker, J. Migaly, C. Guy, C. R. Mantyh, and A. Wax, “Detection of intestinal dysplasia using angle-resolved low coherence interferometry,” J. Biomed. Opt.16(10), 106002 (2011).
[CrossRef] [PubMed]

Migaly, J.

N. Terry, Y. Zhu, J. K. M. Thacker, J. Migaly, C. Guy, C. R. Mantyh, and A. Wax, “Detection of intestinal dysplasia using angle-resolved low coherence interferometry,” J. Biomed. Opt.16(10), 106002 (2011).
[CrossRef] [PubMed]

Moes, C. J.

Mourant, J. R.

Overholt, B. F.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Panjehpour, M.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Pfefer, T. J.

Prahl, S. A.

Pyhtila, J. W.

J. W. Pyhtila, K. J. Chalut, J. D. Boyer, J. Keener, T. D’Amico, M. Gottfried, F. Gress, and A. Wax, “In situ detection of nuclear atypia in Barrett’s esophagus by using angle-resolved low-coherence interferometry,” Gastrointest. Endosc.65(3), 487–491 (2007).
[CrossRef] [PubMed]

J. W. Pyhtila, H. Ma, A. J. Simnick, A. Chilkoti, and A. Wax, “Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry,” J. Biomed. Opt.11(3), 034022 (2006).
[CrossRef] [PubMed]

Rinehart, M. T.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Roy, H. K.

Shaheen, N. J.

Y. Zhu, N. G. Terry, J. T. Woosley, N. J. Shaheen, and A. Wax, “Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology,” J. Biomed. Opt.16(1), 011003 (2011).
[CrossRef] [PubMed]

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Simnick, A. J.

J. W. Pyhtila, H. Ma, A. J. Simnick, A. Chilkoti, and A. Wax, “Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry,” J. Biomed. Opt.11(3), 034022 (2006).
[CrossRef] [PubMed]

Terry, N.

N. Terry, Y. Zhu, J. K. M. Thacker, J. Migaly, C. Guy, C. R. Mantyh, and A. Wax, “Detection of intestinal dysplasia using angle-resolved low coherence interferometry,” J. Biomed. Opt.16(10), 106002 (2011).
[CrossRef] [PubMed]

Terry, N. G.

Y. Zhu, N. G. Terry, J. T. Woosley, N. J. Shaheen, and A. Wax, “Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology,” J. Biomed. Opt.16(1), 011003 (2011).
[CrossRef] [PubMed]

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Thacker, J. K. M.

N. Terry, Y. Zhu, J. K. M. Thacker, J. Migaly, C. Guy, C. R. Mantyh, and A. Wax, “Detection of intestinal dysplasia using angle-resolved low coherence interferometry,” J. Biomed. Opt.16(10), 106002 (2011).
[CrossRef] [PubMed]

Trembath, D.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

van Gemert, M. J.

van Marie, J.

van Staveren, H. J.

Wali, R. K.

Wang, D.

Wax, A.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Y. Zhu, N. G. Terry, J. T. Woosley, N. J. Shaheen, and A. Wax, “Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology,” J. Biomed. Opt.16(1), 011003 (2011).
[CrossRef] [PubMed]

N. Terry, Y. Zhu, J. K. M. Thacker, J. Migaly, C. Guy, C. R. Mantyh, and A. Wax, “Detection of intestinal dysplasia using angle-resolved low coherence interferometry,” J. Biomed. Opt.16(10), 106002 (2011).
[CrossRef] [PubMed]

M. Giacomelli, Y. Zhu, J. Lee, and A. Wax, “Size and shape determination of spheroidal scatterers using two-dimensional angle resolved scattering,” Opt. Express18(14), 14616–14626 (2010).
[CrossRef] [PubMed]

J. W. Pyhtila, K. J. Chalut, J. D. Boyer, J. Keener, T. D’Amico, M. Gottfried, F. Gress, and A. Wax, “In situ detection of nuclear atypia in Barrett’s esophagus by using angle-resolved low-coherence interferometry,” Gastrointest. Endosc.65(3), 487–491 (2007).
[CrossRef] [PubMed]

J. W. Pyhtila, H. Ma, A. J. Simnick, A. Chilkoti, and A. Wax, “Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry,” J. Biomed. Opt.11(3), 034022 (2006).
[CrossRef] [PubMed]

A. Wax, C. H. Yang, V. Backman, K. Badizadegan, C. W. Boone, R. R. Dasari, and M. S. Feld, “Cellular organization and substructure measured using angle-resolved low-coherence interferometry,” Biophys. J.82(4), 2256–2264 (2002).
[CrossRef] [PubMed]

Woosley, J. T.

Y. Zhu, N. G. Terry, J. T. Woosley, N. J. Shaheen, and A. Wax, “Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology,” J. Biomed. Opt.16(1), 011003 (2011).
[CrossRef] [PubMed]

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Yang, C. H.

A. Wax, C. H. Yang, V. Backman, K. Badizadegan, C. W. Boone, R. R. Dasari, and M. S. Feld, “Cellular organization and substructure measured using angle-resolved low-coherence interferometry,” Biophys. J.82(4), 2256–2264 (2002).
[CrossRef] [PubMed]

Zhu, Y.

N. Terry, Y. Zhu, J. K. M. Thacker, J. Migaly, C. Guy, C. R. Mantyh, and A. Wax, “Detection of intestinal dysplasia using angle-resolved low coherence interferometry,” J. Biomed. Opt.16(10), 106002 (2011).
[CrossRef] [PubMed]

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Y. Zhu, N. G. Terry, J. T. Woosley, N. J. Shaheen, and A. Wax, “Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology,” J. Biomed. Opt.16(1), 011003 (2011).
[CrossRef] [PubMed]

M. Giacomelli, Y. Zhu, J. Lee, and A. Wax, “Size and shape determination of spheroidal scatterers using two-dimensional angle resolved scattering,” Opt. Express18(14), 14616–14626 (2010).
[CrossRef] [PubMed]

Ziefle, C. G.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Appl. Opt. (3)

Biomed. Opt. Express (1)

Biophys. J. (1)

A. Wax, C. H. Yang, V. Backman, K. Badizadegan, C. W. Boone, R. R. Dasari, and M. S. Feld, “Cellular organization and substructure measured using angle-resolved low-coherence interferometry,” Biophys. J.82(4), 2256–2264 (2002).
[CrossRef] [PubMed]

Gastroenterology (1)

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of Dysplasia in Barrett’s Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Gastrointest. Endosc. (1)

J. W. Pyhtila, K. J. Chalut, J. D. Boyer, J. Keener, T. D’Amico, M. Gottfried, F. Gress, and A. Wax, “In situ detection of nuclear atypia in Barrett’s esophagus by using angle-resolved low-coherence interferometry,” Gastrointest. Endosc.65(3), 487–491 (2007).
[CrossRef] [PubMed]

J. Biomed. Opt. (3)

J. W. Pyhtila, H. Ma, A. J. Simnick, A. Chilkoti, and A. Wax, “Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry,” J. Biomed. Opt.11(3), 034022 (2006).
[CrossRef] [PubMed]

Y. Zhu, N. G. Terry, J. T. Woosley, N. J. Shaheen, and A. Wax, “Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology,” J. Biomed. Opt.16(1), 011003 (2011).
[CrossRef] [PubMed]

N. Terry, Y. Zhu, J. K. M. Thacker, J. Migaly, C. Guy, C. R. Mantyh, and A. Wax, “Detection of intestinal dysplasia using angle-resolved low coherence interferometry,” J. Biomed. Opt.16(10), 106002 (2011).
[CrossRef] [PubMed]

Opt. Express (1)

Opt. Lett. (1)

Other (1)

J. P. Bouchard, I. Noiseux, I. Veilleux, and O. Mermut, “The role of optical tissue phantom in verification and validation of medical imaging devices,” in BioPhotonics, 2011 International Workshop on. (2011).
[CrossRef]

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Figures (4)

Fig. 1
Fig. 1

(Inset) Comparison of 1D and 2D a/LCI measurements superimposed on a typical scattering pattern, given as field amplitude. (Main) New 2D a/LCI system schematic. Light from Ti:Sapphire laser (λ = 830 nm Δλ = 17nm) is split into an input to the sample and a reference beam (red). Light scattered by the sample (green) is imaged onto the entrance slit of the spectrometer, located in a conjugate Fourier plane. By including an angle scanning mirror between L3 and L4, light in different scattering planes is made to overlap the entrance slit such that the scattering across the 2D plane can be measured.

Fig. 2
Fig. 2

Typical images of the fabricated mold under bright field illumination. (Left) Image of ‘A’ configuration sample with scattering features of nominally 10 μm diameter and 10 μm spacing. (Center) Image of ‘B’ configuration sample with scattering features of nominally 10 μm diameter and 5 μm spacing. Measurements shown on figure are from image analysis. (Right) Plot of correlation measurements of scatterer spacing (center to center) for image analysis of bright field images (green squares) and 2D a/LCI (blue stars). Theoretical values are based on fabrication mold parameters.

Fig. 3
Fig. 3

(A) Bright field image of the 20 μm hexagonal packed phantom. (B) Scattering plane from the 20 μm SAM phantom collected via 2D a/LCI. (C) Correlation plane of the 20 μm SAM phantom. (D) Correlation of the 20 μm SAM phantom as a function of radial displacement.

Fig. 4
Fig. 4

(A) Bright field image of the crypt configuration scatterers (scale bar = 100 μm). (B) Scattering plane image collected via 2D a/LCI. (C) Correlation plane of for the crypt configuration phantom. (D) Correlation of the crypt configuration phantom as a function of radial displacement (log scale).

Tables (1)

Tables Icon

Table 1 Comparison of correlation measurements via 2D a/LCI and image analysis of microscope images.

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