Abstract

A tomographic setup that provides the co-registration of photoacoustic (PA) and ultrasound (US) images is presented. For pulse-echo US-tomography laser-induced broadband plane ultrasonic waves are produced by illuminating an optically absorbing target with a short near-infrared laser pulse. Part of the same pulse is frequency doubled and used for the generation of PA waves within the object of interest. The laser-generated plane waves are scattered at the imaging object and measured with the same interferometric detector that also acquires the photoacoustic signals. After collection and separation of the data image reconstruction is done using back-projection resulting in three-dimensional, co-registered PA and US images. The setup is characterized and the resolution in PA and US mode is estimated to be about 85 µm and 40 µm, respectively. Besides measurements on phantoms the performance is also tested on a biological sample.

© 2013 Optical Society of America

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    [CrossRef]
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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  38. X. L. Deán-Ben, V. Ntziachristos, D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt. 17(11), 110504 (2012).
    [CrossRef] [PubMed]

2013

R. Nuster, N. Schmitner, G. Wurzinger, S. Gratt, W. Salvenmoser, D. Meyer, G. Paltauf, “Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection,” J Biophotonics 6(6-7), 549–559 (2013).
[CrossRef] [PubMed]

H. R. Shive, “Zebrafish models for human cancer,” Vet. Pathol. 50(3), 468–482 (2013).
[CrossRef] [PubMed]

2012

W. Choi, K. D. Poss, “Cardiac Regeneration,” Curr. Top. Dev. Biol. 100, 319 (2012).

C. Kizil, J. Kaslin, V. Kroehne, M. Brand, “Adult neurogenesis and brain regeneration in zebrafish,” Dev. Neurobiol. 72(3), 429–461 (2012).
[CrossRef] [PubMed]

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol. 57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

S. Ye, R. Yang, J. Xiong, K. K. Shung, Q. Zhou, C. Li, Q. Ren, “Label-free imaging of zebrafish larvae in vivo by photoacoustic microscopy,” Biomed. Opt. Express 3(2), 360–365 (2012).
[CrossRef] [PubMed]

L. V. Wang, S. Hu, “Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs,” Science 335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt. 17(5), 056016 (2012).
[CrossRef] [PubMed]

M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
[CrossRef] [PubMed]

X. L. Deán-Ben, V. Ntziachristos, D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt. 17(11), 110504 (2012).
[CrossRef] [PubMed]

2011

2010

Z. Cao, L. D. Jensen, P. Rouhi, K. Hosaka, T. Länne, J. F. Steffensen, E. Wahlberg, Y. Cao, “Hypoxia-induced retinopathy model in adult zebrafish,” Nat. Protoc. 5(12), 1903–1910 (2010).
[CrossRef] [PubMed]

R. Nuster, M. Holotta, C. Kremser, H. Grossauer, P. Burgholzer, G. Paltauf, “Photoacoustic microtomography using optical interferometric detection,” J. Biomed. Opt. 15(2), 021307 (2010).
[CrossRef] [PubMed]

2009

J. B. Moss, P. Koustubhan, M. Greenman, M. J. Parsons, I. Walter, L. G. Moss, “Regeneration of the Pancreas in Adult Zebrafish,” Diabetes 58(8), 1844–1851 (2009).
[CrossRef] [PubMed]

G. Paltauf, R. Nuster, P. Burgholzer, “Weight factors for limited angle photoacoustic tomography,” Phys. Med. Biol. 54(11), 3303–3314 (2009).
[CrossRef] [PubMed]

G. Paltauf, R. Nuster, P. Burgholzer, “Characterization of integrating ultrasound detectors for photoacoustic tomography,” J. Appl. Phys. 105(10), 102026 (2009).
[CrossRef]

T. Harrison, J. C. Ranasinghesagara, H. Lu, K. Mathewson, A. Walsh, R. J. Zemp, “Combined photoacoustic and ultrasound biomicroscopy,” Opt. Express 17(24), 22041–22046 (2009).
[CrossRef] [PubMed]

R. Nuster, S. Gratt, K. Passler, H. Grun, T. Berer, P. Burgholzer, G. Paltauf, “Comparison of optical and piezoelectric integrating line detectors,” Photons Plus Ultrasound: Imaging and Sensing 2009, 7177 (2009).

E. Z. Zhang, J. G. Laufer, R. B. Pedley, P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
[CrossRef] [PubMed]

2008

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, T. G. van Leeuwen, “Real-time in vivo photoacoustic and ultrasound imaging,” J. Biomed. Opt. 13(5), 050510 (2008).
[CrossRef] [PubMed]

L. Sun, C. L. Lien, X. Xu, K. K. Shung, “In vivo cardiac imaging of adult zebrafish using high frequency ultrasound (45-75 MHz),” Ultrasound Med. Biol. 34(1), 31–39 (2008).
[CrossRef] [PubMed]

2007

W. Goessling, T. E. North, L. I. Zon, “Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors,” Nat. Methods 4(7), 551–553 (2007).
[CrossRef] [PubMed]

S. Manohar, R. G. H. Willemink, F. van der Heijden, C. H. Slump, T. G. van Leeuwen, “Concomitant speed-of-sound tomography in photoacoustic imaging,” Appl. Phys. Lett. 91(13), 131911 (2007).
[CrossRef]

G. Paltauf, R. Nuster, M. Haltmeier, P. Burgholzer, “Photoacoustic tomography using a Mach-Zehnder interferometer as an acoustic line detector,” Appl. Opt. 46(16), 3352–3358 (2007).
[CrossRef] [PubMed]

G. Paltauf, R. Nuster, M. Haltmeier, P. Burgholzer, “Experimental evaluation of reconstruction algorithms for limited view photoacoustic tomography with line detectors,” Inverse Probl. 23(6), S81–S94 (2007).
[CrossRef]

2006

X. Jin, L. V. Wang, “Thermoacoustic tomography with correction for acoustic speed variations,” Phys. Med. Biol. 51(24), 6437–6448 (2006).
[CrossRef] [PubMed]

H. B. Jiang, Z. Yuan, X. J. Gu, “Spatially Varying Optical and Acoustic Property Reconstruction Using Finite-Element-Based Photoacoustic Tomography,” J. Opt. Soc. Am. A 23(4), 878–888 (2006).
[CrossRef] [PubMed]

M. H. Xu, L. V. Wang, “Photoacoustic Imaging in Biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[CrossRef]

2005

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, M. Frenz, “Combined Ultrasound and Optoacoustic System for Real-Time High-Contrast Vascular Imaging in Vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[CrossRef] [PubMed]

M. Jaeger, J. J. Niederhauser, M. Hejazi, M. Frenz, “Diffraction-free acoustic detection for optoacoustic depth profiling of tissue using an optically transparent polyvinylidene fluoride pressure transducer operated in backward and forward mode,” J. Biomed. Opt. 10(2), 024035 (2005).
[CrossRef] [PubMed]

M. H. Xu, L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 71(1), 016706 (2005).
[CrossRef] [PubMed]

2004

Y. Xu, L. V. Wang, G. Ambartsoumian, P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[CrossRef] [PubMed]

S. Y. Emelianov, S. R. Aglyamov, J. Shah, S. Sethuraman, W. G. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, A. Oraevsky, “Combined ultrasound, optoacoustic and elasticity imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 101–112 (2004).

P. C. Beard, E. Z. Zhang, B. T. Cox, “Transparent Fabry Perot polymer film ultrasound array for backward-mode photoacoustic imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 230–237 (2004).

Aglyamov, S. R.

S. Y. Emelianov, S. R. Aglyamov, J. Shah, S. Sethuraman, W. G. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, A. Oraevsky, “Combined ultrasound, optoacoustic and elasticity imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 101–112 (2004).

Ambartsoumian, G.

Y. Xu, L. V. Wang, G. Ambartsoumian, P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[CrossRef] [PubMed]

Bamber, J.

M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
[CrossRef] [PubMed]

Beard, P.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt. 17(5), 056016 (2012).
[CrossRef] [PubMed]

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[CrossRef] [PubMed]

Beard, P. C.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
[CrossRef] [PubMed]

P. C. Beard, E. Z. Zhang, B. T. Cox, “Transparent Fabry Perot polymer film ultrasound array for backward-mode photoacoustic imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 230–237 (2004).

Berer, T.

R. Nuster, S. Gratt, K. Passler, H. Grun, T. Berer, P. Burgholzer, G. Paltauf, “Comparison of optical and piezoelectric integrating line detectors,” Photons Plus Ultrasound: Imaging and Sensing 2009, 7177 (2009).

Brand, M.

C. Kizil, J. Kaslin, V. Kroehne, M. Brand, “Adult neurogenesis and brain regeneration in zebrafish,” Dev. Neurobiol. 72(3), 429–461 (2012).
[CrossRef] [PubMed]

Brands, P. J.

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, T. G. van Leeuwen, “Real-time in vivo photoacoustic and ultrasound imaging,” J. Biomed. Opt. 13(5), 050510 (2008).
[CrossRef] [PubMed]

Burgholzer, P.

R. Nuster, M. Holotta, C. Kremser, H. Grossauer, P. Burgholzer, G. Paltauf, “Photoacoustic microtomography using optical interferometric detection,” J. Biomed. Opt. 15(2), 021307 (2010).
[CrossRef] [PubMed]

G. Paltauf, R. Nuster, P. Burgholzer, “Characterization of integrating ultrasound detectors for photoacoustic tomography,” J. Appl. Phys. 105(10), 102026 (2009).
[CrossRef]

G. Paltauf, R. Nuster, P. Burgholzer, “Weight factors for limited angle photoacoustic tomography,” Phys. Med. Biol. 54(11), 3303–3314 (2009).
[CrossRef] [PubMed]

R. Nuster, S. Gratt, K. Passler, H. Grun, T. Berer, P. Burgholzer, G. Paltauf, “Comparison of optical and piezoelectric integrating line detectors,” Photons Plus Ultrasound: Imaging and Sensing 2009, 7177 (2009).

G. Paltauf, R. Nuster, M. Haltmeier, P. Burgholzer, “Photoacoustic tomography using a Mach-Zehnder interferometer as an acoustic line detector,” Appl. Opt. 46(16), 3352–3358 (2007).
[CrossRef] [PubMed]

G. Paltauf, R. Nuster, M. Haltmeier, P. Burgholzer, “Experimental evaluation of reconstruction algorithms for limited view photoacoustic tomography with line detectors,” Inverse Probl. 23(6), S81–S94 (2007).
[CrossRef]

Cao, Y.

Z. Cao, L. D. Jensen, P. Rouhi, K. Hosaka, T. Länne, J. F. Steffensen, E. Wahlberg, Y. Cao, “Hypoxia-induced retinopathy model in adult zebrafish,” Nat. Protoc. 5(12), 1903–1910 (2010).
[CrossRef] [PubMed]

Cao, Z.

Z. Cao, L. D. Jensen, P. Rouhi, K. Hosaka, T. Länne, J. F. Steffensen, E. Wahlberg, Y. Cao, “Hypoxia-induced retinopathy model in adult zebrafish,” Nat. Protoc. 5(12), 1903–1910 (2010).
[CrossRef] [PubMed]

Choi, W.

W. Choi, K. D. Poss, “Cardiac Regeneration,” Curr. Top. Dev. Biol. 100, 319 (2012).

Cox, B.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt. 17(5), 056016 (2012).
[CrossRef] [PubMed]

Cox, B. T.

P. C. Beard, E. Z. Zhang, B. T. Cox, “Transparent Fabry Perot polymer film ultrasound array for backward-mode photoacoustic imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 230–237 (2004).

Deán-Ben, X. L.

X. L. Deán-Ben, V. Ntziachristos, D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt. 17(11), 110504 (2012).
[CrossRef] [PubMed]

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol. 57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

Distel, M.

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol. 57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

Emelianov, S. Y.

S. Y. Emelianov, S. R. Aglyamov, J. Shah, S. Sethuraman, W. G. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, A. Oraevsky, “Combined ultrasound, optoacoustic and elasticity imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 101–112 (2004).

Frenz, M.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, M. Frenz, “Combined Ultrasound and Optoacoustic System for Real-Time High-Contrast Vascular Imaging in Vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[CrossRef] [PubMed]

M. Jaeger, J. J. Niederhauser, M. Hejazi, M. Frenz, “Diffraction-free acoustic detection for optoacoustic depth profiling of tissue using an optically transparent polyvinylidene fluoride pressure transducer operated in backward and forward mode,” J. Biomed. Opt. 10(2), 024035 (2005).
[CrossRef] [PubMed]

Gertsch, A.

M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
[CrossRef] [PubMed]

Goessling, W.

W. Goessling, T. E. North, L. I. Zon, “Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors,” Nat. Methods 4(7), 551–553 (2007).
[CrossRef] [PubMed]

Gratt, S.

R. Nuster, N. Schmitner, G. Wurzinger, S. Gratt, W. Salvenmoser, D. Meyer, G. Paltauf, “Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection,” J Biophotonics 6(6-7), 549–559 (2013).
[CrossRef] [PubMed]

R. Nuster, S. Gratt, K. Passler, H. Grun, T. Berer, P. Burgholzer, G. Paltauf, “Comparison of optical and piezoelectric integrating line detectors,” Photons Plus Ultrasound: Imaging and Sensing 2009, 7177 (2009).

Greenman, M.

J. B. Moss, P. Koustubhan, M. Greenman, M. J. Parsons, I. Walter, L. G. Moss, “Regeneration of the Pancreas in Adult Zebrafish,” Diabetes 58(8), 1844–1851 (2009).
[CrossRef] [PubMed]

Grossauer, H.

R. Nuster, M. Holotta, C. Kremser, H. Grossauer, P. Burgholzer, G. Paltauf, “Photoacoustic microtomography using optical interferometric detection,” J. Biomed. Opt. 15(2), 021307 (2010).
[CrossRef] [PubMed]

Grun, H.

R. Nuster, S. Gratt, K. Passler, H. Grun, T. Berer, P. Burgholzer, G. Paltauf, “Comparison of optical and piezoelectric integrating line detectors,” Photons Plus Ultrasound: Imaging and Sensing 2009, 7177 (2009).

Gu, X. J.

Haltmeier, M.

G. Paltauf, R. Nuster, M. Haltmeier, P. Burgholzer, “Experimental evaluation of reconstruction algorithms for limited view photoacoustic tomography with line detectors,” Inverse Probl. 23(6), S81–S94 (2007).
[CrossRef]

G. Paltauf, R. Nuster, M. Haltmeier, P. Burgholzer, “Photoacoustic tomography using a Mach-Zehnder interferometer as an acoustic line detector,” Appl. Opt. 46(16), 3352–3358 (2007).
[CrossRef] [PubMed]

Harris-Birtill, D.

M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
[CrossRef] [PubMed]

Harrison, T.

Hejazi, M.

M. Jaeger, J. J. Niederhauser, M. Hejazi, M. Frenz, “Diffraction-free acoustic detection for optoacoustic depth profiling of tissue using an optically transparent polyvinylidene fluoride pressure transducer operated in backward and forward mode,” J. Biomed. Opt. 10(2), 024035 (2005).
[CrossRef] [PubMed]

Holotta, M.

R. Nuster, M. Holotta, C. Kremser, H. Grossauer, P. Burgholzer, G. Paltauf, “Photoacoustic microtomography using optical interferometric detection,” J. Biomed. Opt. 15(2), 021307 (2010).
[CrossRef] [PubMed]

Hosaka, K.

Z. Cao, L. D. Jensen, P. Rouhi, K. Hosaka, T. Länne, J. F. Steffensen, E. Wahlberg, Y. Cao, “Hypoxia-induced retinopathy model in adult zebrafish,” Nat. Protoc. 5(12), 1903–1910 (2010).
[CrossRef] [PubMed]

Hu, S.

L. V. Wang, S. Hu, “Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs,” Science 335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

Jaeger, M.

M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
[CrossRef] [PubMed]

M. Jaeger, J. J. Niederhauser, M. Hejazi, M. Frenz, “Diffraction-free acoustic detection for optoacoustic depth profiling of tissue using an optically transparent polyvinylidene fluoride pressure transducer operated in backward and forward mode,” J. Biomed. Opt. 10(2), 024035 (2005).
[CrossRef] [PubMed]

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, M. Frenz, “Combined Ultrasound and Optoacoustic System for Real-Time High-Contrast Vascular Imaging in Vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[CrossRef] [PubMed]

Jensen, L. D.

Z. Cao, L. D. Jensen, P. Rouhi, K. Hosaka, T. Länne, J. F. Steffensen, E. Wahlberg, Y. Cao, “Hypoxia-induced retinopathy model in adult zebrafish,” Nat. Protoc. 5(12), 1903–1910 (2010).
[CrossRef] [PubMed]

Jiang, H. B.

Jin, X.

X. Jin, L. V. Wang, “Thermoacoustic tomography with correction for acoustic speed variations,” Phys. Med. Biol. 51(24), 6437–6448 (2006).
[CrossRef] [PubMed]

Johnson, P.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt. 17(5), 056016 (2012).
[CrossRef] [PubMed]

Jose, J.

Karpiouk, A.

S. Y. Emelianov, S. R. Aglyamov, J. Shah, S. Sethuraman, W. G. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, A. Oraevsky, “Combined ultrasound, optoacoustic and elasticity imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 101–112 (2004).

Kaslin, J.

C. Kizil, J. Kaslin, V. Kroehne, M. Brand, “Adult neurogenesis and brain regeneration in zebrafish,” Dev. Neurobiol. 72(3), 429–461 (2012).
[CrossRef] [PubMed]

Kizil, C.

C. Kizil, J. Kaslin, V. Kroehne, M. Brand, “Adult neurogenesis and brain regeneration in zebrafish,” Dev. Neurobiol. 72(3), 429–461 (2012).
[CrossRef] [PubMed]

Kolkman, R. G. M.

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, T. G. van Leeuwen, “Real-time in vivo photoacoustic and ultrasound imaging,” J. Biomed. Opt. 13(5), 050510 (2008).
[CrossRef] [PubMed]

Koustubhan, P.

J. B. Moss, P. Koustubhan, M. Greenman, M. J. Parsons, I. Walter, L. G. Moss, “Regeneration of the Pancreas in Adult Zebrafish,” Diabetes 58(8), 1844–1851 (2009).
[CrossRef] [PubMed]

Kremser, C.

R. Nuster, M. Holotta, C. Kremser, H. Grossauer, P. Burgholzer, G. Paltauf, “Photoacoustic microtomography using optical interferometric detection,” J. Biomed. Opt. 15(2), 021307 (2010).
[CrossRef] [PubMed]

Kroehne, V.

C. Kizil, J. Kaslin, V. Kroehne, M. Brand, “Adult neurogenesis and brain regeneration in zebrafish,” Dev. Neurobiol. 72(3), 429–461 (2012).
[CrossRef] [PubMed]

Kuchment, P.

Y. Xu, L. V. Wang, G. Ambartsoumian, P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[CrossRef] [PubMed]

Länne, T.

Z. Cao, L. D. Jensen, P. Rouhi, K. Hosaka, T. Länne, J. F. Steffensen, E. Wahlberg, Y. Cao, “Hypoxia-induced retinopathy model in adult zebrafish,” Nat. Protoc. 5(12), 1903–1910 (2010).
[CrossRef] [PubMed]

Laufer, J.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt. 17(5), 056016 (2012).
[CrossRef] [PubMed]

Laufer, J. G.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
[CrossRef] [PubMed]

Leach, S. D.

S. Liu, S. D. Leach, “Screening Pancreatic Oncogenes in Zebrafish Using the Gal4/UAS System,” Methods Cell Biol. 105, 367–381 (2011).
[CrossRef] [PubMed]

Lemor, R.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, M. Frenz, “Combined Ultrasound and Optoacoustic System for Real-Time High-Contrast Vascular Imaging in Vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[CrossRef] [PubMed]

Li, C.

Lien, C. L.

L. Sun, C. L. Lien, X. Xu, K. K. Shung, “In vivo cardiac imaging of adult zebrafish using high frequency ultrasound (45-75 MHz),” Ultrasound Med. Biol. 34(1), 31–39 (2008).
[CrossRef] [PubMed]

Liu, S.

S. Liu, S. D. Leach, “Screening Pancreatic Oncogenes in Zebrafish Using the Gal4/UAS System,” Methods Cell Biol. 105, 367–381 (2011).
[CrossRef] [PubMed]

Lu, H.

Ma, R.

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol. 57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

Manohar, S.

Mathewson, K.

Meyer, D.

R. Nuster, N. Schmitner, G. Wurzinger, S. Gratt, W. Salvenmoser, D. Meyer, G. Paltauf, “Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection,” J Biophotonics 6(6-7), 549–559 (2013).
[CrossRef] [PubMed]

Moss, J. B.

J. B. Moss, P. Koustubhan, M. Greenman, M. J. Parsons, I. Walter, L. G. Moss, “Regeneration of the Pancreas in Adult Zebrafish,” Diabetes 58(8), 1844–1851 (2009).
[CrossRef] [PubMed]

Moss, L. G.

J. B. Moss, P. Koustubhan, M. Greenman, M. J. Parsons, I. Walter, L. G. Moss, “Regeneration of the Pancreas in Adult Zebrafish,” Diabetes 58(8), 1844–1851 (2009).
[CrossRef] [PubMed]

Motamedi, M.

S. Y. Emelianov, S. R. Aglyamov, J. Shah, S. Sethuraman, W. G. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, A. Oraevsky, “Combined ultrasound, optoacoustic and elasticity imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 101–112 (2004).

Niederhauser, J. J.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, M. Frenz, “Combined Ultrasound and Optoacoustic System for Real-Time High-Contrast Vascular Imaging in Vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[CrossRef] [PubMed]

M. Jaeger, J. J. Niederhauser, M. Hejazi, M. Frenz, “Diffraction-free acoustic detection for optoacoustic depth profiling of tissue using an optically transparent polyvinylidene fluoride pressure transducer operated in backward and forward mode,” J. Biomed. Opt. 10(2), 024035 (2005).
[CrossRef] [PubMed]

North, T. E.

W. Goessling, T. E. North, L. I. Zon, “Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors,” Nat. Methods 4(7), 551–553 (2007).
[CrossRef] [PubMed]

Ntziachristos, V.

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol. 57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

X. L. Deán-Ben, V. Ntziachristos, D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt. 17(11), 110504 (2012).
[CrossRef] [PubMed]

Nuster, R.

R. Nuster, N. Schmitner, G. Wurzinger, S. Gratt, W. Salvenmoser, D. Meyer, G. Paltauf, “Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection,” J Biophotonics 6(6-7), 549–559 (2013).
[CrossRef] [PubMed]

R. Nuster, M. Holotta, C. Kremser, H. Grossauer, P. Burgholzer, G. Paltauf, “Photoacoustic microtomography using optical interferometric detection,” J. Biomed. Opt. 15(2), 021307 (2010).
[CrossRef] [PubMed]

G. Paltauf, R. Nuster, P. Burgholzer, “Weight factors for limited angle photoacoustic tomography,” Phys. Med. Biol. 54(11), 3303–3314 (2009).
[CrossRef] [PubMed]

G. Paltauf, R. Nuster, P. Burgholzer, “Characterization of integrating ultrasound detectors for photoacoustic tomography,” J. Appl. Phys. 105(10), 102026 (2009).
[CrossRef]

R. Nuster, S. Gratt, K. Passler, H. Grun, T. Berer, P. Burgholzer, G. Paltauf, “Comparison of optical and piezoelectric integrating line detectors,” Photons Plus Ultrasound: Imaging and Sensing 2009, 7177 (2009).

G. Paltauf, R. Nuster, M. Haltmeier, P. Burgholzer, “Photoacoustic tomography using a Mach-Zehnder interferometer as an acoustic line detector,” Appl. Opt. 46(16), 3352–3358 (2007).
[CrossRef] [PubMed]

G. Paltauf, R. Nuster, M. Haltmeier, P. Burgholzer, “Experimental evaluation of reconstruction algorithms for limited view photoacoustic tomography with line detectors,” Inverse Probl. 23(6), S81–S94 (2007).
[CrossRef]

O’Flynn, E.

M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
[CrossRef] [PubMed]

Oraevsky, A.

S. Y. Emelianov, S. R. Aglyamov, J. Shah, S. Sethuraman, W. G. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, A. Oraevsky, “Combined ultrasound, optoacoustic and elasticity imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 101–112 (2004).

Paltauf, G.

R. Nuster, N. Schmitner, G. Wurzinger, S. Gratt, W. Salvenmoser, D. Meyer, G. Paltauf, “Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection,” J Biophotonics 6(6-7), 549–559 (2013).
[CrossRef] [PubMed]

R. Nuster, M. Holotta, C. Kremser, H. Grossauer, P. Burgholzer, G. Paltauf, “Photoacoustic microtomography using optical interferometric detection,” J. Biomed. Opt. 15(2), 021307 (2010).
[CrossRef] [PubMed]

G. Paltauf, R. Nuster, P. Burgholzer, “Weight factors for limited angle photoacoustic tomography,” Phys. Med. Biol. 54(11), 3303–3314 (2009).
[CrossRef] [PubMed]

G. Paltauf, R. Nuster, P. Burgholzer, “Characterization of integrating ultrasound detectors for photoacoustic tomography,” J. Appl. Phys. 105(10), 102026 (2009).
[CrossRef]

R. Nuster, S. Gratt, K. Passler, H. Grun, T. Berer, P. Burgholzer, G. Paltauf, “Comparison of optical and piezoelectric integrating line detectors,” Photons Plus Ultrasound: Imaging and Sensing 2009, 7177 (2009).

G. Paltauf, R. Nuster, M. Haltmeier, P. Burgholzer, “Photoacoustic tomography using a Mach-Zehnder interferometer as an acoustic line detector,” Appl. Opt. 46(16), 3352–3358 (2007).
[CrossRef] [PubMed]

G. Paltauf, R. Nuster, M. Haltmeier, P. Burgholzer, “Experimental evaluation of reconstruction algorithms for limited view photoacoustic tomography with line detectors,” Inverse Probl. 23(6), S81–S94 (2007).
[CrossRef]

Parsons, M. J.

J. B. Moss, P. Koustubhan, M. Greenman, M. J. Parsons, I. Walter, L. G. Moss, “Regeneration of the Pancreas in Adult Zebrafish,” Diabetes 58(8), 1844–1851 (2009).
[CrossRef] [PubMed]

Passler, K.

R. Nuster, S. Gratt, K. Passler, H. Grun, T. Berer, P. Burgholzer, G. Paltauf, “Comparison of optical and piezoelectric integrating line detectors,” Photons Plus Ultrasound: Imaging and Sensing 2009, 7177 (2009).

Pedley, B.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt. 17(5), 056016 (2012).
[CrossRef] [PubMed]

Pedley, R. B.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
[CrossRef] [PubMed]

Piras, D.

Poss, K. D.

W. Choi, K. D. Poss, “Cardiac Regeneration,” Curr. Top. Dev. Biol. 100, 319 (2012).

Ranasinghesagara, J. C.

Razansky, D.

X. L. Deán-Ben, V. Ntziachristos, D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt. 17(11), 110504 (2012).
[CrossRef] [PubMed]

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol. 57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

Ren, Q.

Resink, S.

Rouhi, P.

Z. Cao, L. D. Jensen, P. Rouhi, K. Hosaka, T. Länne, J. F. Steffensen, E. Wahlberg, Y. Cao, “Hypoxia-induced retinopathy model in adult zebrafish,” Nat. Protoc. 5(12), 1903–1910 (2010).
[CrossRef] [PubMed]

Salvenmoser, W.

R. Nuster, N. Schmitner, G. Wurzinger, S. Gratt, W. Salvenmoser, D. Meyer, G. Paltauf, “Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection,” J Biophotonics 6(6-7), 549–559 (2013).
[CrossRef] [PubMed]

Schmitner, N.

R. Nuster, N. Schmitner, G. Wurzinger, S. Gratt, W. Salvenmoser, D. Meyer, G. Paltauf, “Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection,” J Biophotonics 6(6-7), 549–559 (2013).
[CrossRef] [PubMed]

Schmitt, R.

S. Y. Emelianov, S. R. Aglyamov, J. Shah, S. Sethuraman, W. G. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, A. Oraevsky, “Combined ultrasound, optoacoustic and elasticity imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 101–112 (2004).

Scott, W. G.

S. Y. Emelianov, S. R. Aglyamov, J. Shah, S. Sethuraman, W. G. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, A. Oraevsky, “Combined ultrasound, optoacoustic and elasticity imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 101–112 (2004).

Sethuraman, S.

S. Y. Emelianov, S. R. Aglyamov, J. Shah, S. Sethuraman, W. G. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, A. Oraevsky, “Combined ultrasound, optoacoustic and elasticity imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 101–112 (2004).

Shah, J.

S. Y. Emelianov, S. R. Aglyamov, J. Shah, S. Sethuraman, W. G. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, A. Oraevsky, “Combined ultrasound, optoacoustic and elasticity imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 101–112 (2004).

Shive, H. R.

H. R. Shive, “Zebrafish models for human cancer,” Vet. Pathol. 50(3), 468–482 (2013).
[CrossRef] [PubMed]

Shung, K. K.

S. Ye, R. Yang, J. Xiong, K. K. Shung, Q. Zhou, C. Li, Q. Ren, “Label-free imaging of zebrafish larvae in vivo by photoacoustic microscopy,” Biomed. Opt. Express 3(2), 360–365 (2012).
[CrossRef] [PubMed]

L. Sun, C. L. Lien, X. Xu, K. K. Shung, “In vivo cardiac imaging of adult zebrafish using high frequency ultrasound (45-75 MHz),” Ultrasound Med. Biol. 34(1), 31–39 (2008).
[CrossRef] [PubMed]

Slump, C. H.

Steenbergen, W.

Steffensen, J. F.

Z. Cao, L. D. Jensen, P. Rouhi, K. Hosaka, T. Länne, J. F. Steffensen, E. Wahlberg, Y. Cao, “Hypoxia-induced retinopathy model in adult zebrafish,” Nat. Protoc. 5(12), 1903–1910 (2010).
[CrossRef] [PubMed]

Sun, L.

L. Sun, C. L. Lien, X. Xu, K. K. Shung, “In vivo cardiac imaging of adult zebrafish using high frequency ultrasound (45-75 MHz),” Ultrasound Med. Biol. 34(1), 31–39 (2008).
[CrossRef] [PubMed]

Treeby, B.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt. 17(5), 056016 (2012).
[CrossRef] [PubMed]

van der Heijden, F.

S. Manohar, R. G. H. Willemink, F. van der Heijden, C. H. Slump, T. G. van Leeuwen, “Concomitant speed-of-sound tomography in photoacoustic imaging,” Appl. Phys. Lett. 91(13), 131911 (2007).
[CrossRef]

van Hespen, J. C. G.

van Leeuwen, T. G.

Wahlberg, E.

Z. Cao, L. D. Jensen, P. Rouhi, K. Hosaka, T. Länne, J. F. Steffensen, E. Wahlberg, Y. Cao, “Hypoxia-induced retinopathy model in adult zebrafish,” Nat. Protoc. 5(12), 1903–1910 (2010).
[CrossRef] [PubMed]

Walsh, A.

Walter, I.

J. B. Moss, P. Koustubhan, M. Greenman, M. J. Parsons, I. Walter, L. G. Moss, “Regeneration of the Pancreas in Adult Zebrafish,” Diabetes 58(8), 1844–1851 (2009).
[CrossRef] [PubMed]

Wang, L. V.

L. V. Wang, S. Hu, “Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs,” Science 335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

M. H. Xu, L. V. Wang, “Photoacoustic Imaging in Biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[CrossRef]

X. Jin, L. V. Wang, “Thermoacoustic tomography with correction for acoustic speed variations,” Phys. Med. Biol. 51(24), 6437–6448 (2006).
[CrossRef] [PubMed]

M. H. Xu, L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 71(1), 016706 (2005).
[CrossRef] [PubMed]

Y. Xu, L. V. Wang, G. Ambartsoumian, P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[CrossRef] [PubMed]

Weber, P.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, M. Frenz, “Combined Ultrasound and Optoacoustic System for Real-Time High-Contrast Vascular Imaging in Vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[CrossRef] [PubMed]

Willemink, R. G. H.

Wurzinger, G.

R. Nuster, N. Schmitner, G. Wurzinger, S. Gratt, W. Salvenmoser, D. Meyer, G. Paltauf, “Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection,” J Biophotonics 6(6-7), 549–559 (2013).
[CrossRef] [PubMed]

Xiong, J.

Xu, M. H.

M. H. Xu, L. V. Wang, “Photoacoustic Imaging in Biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[CrossRef]

M. H. Xu, L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 71(1), 016706 (2005).
[CrossRef] [PubMed]

Xu, X.

L. Sun, C. L. Lien, X. Xu, K. K. Shung, “In vivo cardiac imaging of adult zebrafish using high frequency ultrasound (45-75 MHz),” Ultrasound Med. Biol. 34(1), 31–39 (2008).
[CrossRef] [PubMed]

Xu, Y.

Y. Xu, L. V. Wang, G. Ambartsoumian, P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[CrossRef] [PubMed]

Yang, R.

Ye, S.

Yuan, Z.

Zemp, R. J.

Zhang, E.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt. 17(5), 056016 (2012).
[CrossRef] [PubMed]

Zhang, E. Z.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
[CrossRef] [PubMed]

P. C. Beard, E. Z. Zhang, B. T. Cox, “Transparent Fabry Perot polymer film ultrasound array for backward-mode photoacoustic imaging,” Photons Plus Ultrasound: Imaging and Sensing 5320, 230–237 (2004).

Zhou, Q.

Zon, L. I.

W. Goessling, T. E. North, L. I. Zon, “Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors,” Nat. Methods 4(7), 551–553 (2007).
[CrossRef] [PubMed]

Appl. Opt.

Appl. Phys. Lett.

S. Manohar, R. G. H. Willemink, F. van der Heijden, C. H. Slump, T. G. van Leeuwen, “Concomitant speed-of-sound tomography in photoacoustic imaging,” Appl. Phys. Lett. 91(13), 131911 (2007).
[CrossRef]

Biomed. Opt. Express

Curr. Top. Dev. Biol.

W. Choi, K. D. Poss, “Cardiac Regeneration,” Curr. Top. Dev. Biol. 100, 319 (2012).

Dev. Neurobiol.

C. Kizil, J. Kaslin, V. Kroehne, M. Brand, “Adult neurogenesis and brain regeneration in zebrafish,” Dev. Neurobiol. 72(3), 429–461 (2012).
[CrossRef] [PubMed]

Diabetes

J. B. Moss, P. Koustubhan, M. Greenman, M. J. Parsons, I. Walter, L. G. Moss, “Regeneration of the Pancreas in Adult Zebrafish,” Diabetes 58(8), 1844–1851 (2009).
[CrossRef] [PubMed]

IEEE Trans. Med. Imaging

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, M. Frenz, “Combined Ultrasound and Optoacoustic System for Real-Time High-Contrast Vascular Imaging in Vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[CrossRef] [PubMed]

Interface Focus

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[CrossRef] [PubMed]

Inverse Probl.

G. Paltauf, R. Nuster, M. Haltmeier, P. Burgholzer, “Experimental evaluation of reconstruction algorithms for limited view photoacoustic tomography with line detectors,” Inverse Probl. 23(6), S81–S94 (2007).
[CrossRef]

J Biophotonics

R. Nuster, N. Schmitner, G. Wurzinger, S. Gratt, W. Salvenmoser, D. Meyer, G. Paltauf, “Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection,” J Biophotonics 6(6-7), 549–559 (2013).
[CrossRef] [PubMed]

J. Appl. Phys.

G. Paltauf, R. Nuster, P. Burgholzer, “Characterization of integrating ultrasound detectors for photoacoustic tomography,” J. Appl. Phys. 105(10), 102026 (2009).
[CrossRef]

J. Biomed. Opt.

R. Nuster, M. Holotta, C. Kremser, H. Grossauer, P. Burgholzer, G. Paltauf, “Photoacoustic microtomography using optical interferometric detection,” J. Biomed. Opt. 15(2), 021307 (2010).
[CrossRef] [PubMed]

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt. 17(5), 056016 (2012).
[CrossRef] [PubMed]

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Figures (4)

Fig. 1
Fig. 1

Illustration of the setup for simultaneous laser-ultrasound and photoacoustic imaging. SHG…second harmonic generation, L…lens, BS…beamsplitter, M…mirror, M + PT…piezoactuator with mounted mirror, BPF…optical bandpass filter, BPD…balanced photodetector, HPF…electronic high pass filter.

Fig. 2
Fig. 2

Normalized maximum pressure amplitudes measured by scanning a point detector in a plane at a distance of ~20 mm from the absorber (a). PA signal recorded at the center of the illuminating spot (b) and its spectrum (c).

Fig. 3
Fig. 3

(a) Photograph of the phantom used for estimating the spatial resolution. (b) and (c) maximum amplitude projection US images of two copper wires from different views. The white dotted lines indicate the positions where the wire diameter was measured. (d) and (e) PA images of the maximum amplitude projections of black polymer beads from different views. (f) Normalized intensity profile of the marked sphere in y-direction and its Gaussian fit.

Fig. 4
Fig. 4

(a) and (b) Photographs of the investigated transparent zebrafish. The dotted lines indicate the positions of the displayed sections. (c) Coronal (dorsal to ventral) PA (left) and US (right) maximum amplitude projection images over 10 adjacent slices, indicated by the shaded area in (a). (d) Sagittal (left to right) maximum amplitude projection images over five adjacent sections. The PA image is shown on the left, the corresponding US image on the right. The white dotted lines indicate the positions of the displayed transverse (head to tail) sections in (e) – (i), where an overlay of PA (green) and US (red) images is shown.

Equations (2)

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p 0 ( b ) ( r ) = Ω 0 B ( r 0 , t ) d Ω 0 Ω 0
B ( r 0 , t ) = 2 t t d c s 2 τ 2 d 2 τ ( p ( r 0 , τ ) τ ) d τ , d Ω 0 = d C 0 d n ^ 0 d d ,

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