Abstract

We demonstrate a compact, ultrahigh speed spectral-domain optical coherence microscopy (SD-OCM) system for multiscale imaging of specimens at 840 nm. Using a high speed 512-pixel line scan camera, an imaging speed of 210,000 A-scans per second was demonstrated. Interchangeable water immersion objectives with magnifications of 10×, 20×, and 40× provided co-registered en face cellular-resolution imaging over several size scales. Volumetric OCM data sets and en face OCM images were demonstrated on both normal and pathological human colon and kidney specimens ex vivo with an axial resolution of ~4.2 µm, and transverse resolutions of ~2.9 µm (10×), ~1.7 µm (20×), and ~1.1 µm (40×) in tissue. In addition, en face OCM images acquired with high numerical aperture over an extended field-of-view (FOV) were demonstrated using image mosaicking. Comparison between en face OCM images among different transverse and axial resolutions was demonstrated, which promises to help the design and evaluation of imaging performance of Fourier domain OCM systems at different resolution regimes.

© 2013 OSA

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2012 (5)

H.-C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y. Sheikine, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues,” J. Urol.187(2), 691–699 (2012).
[CrossRef] [PubMed]

V. Jayaraman, G. D. Cole, M. Robertson, A. Uddin, and A. Cable, “High-sweep-rate 1310 nm MEMS-VCSEL with 150 nm continuous tuning range,” Electron. Lett.48(14), 867–868 (2012).
[CrossRef]

B. W. Graf and S. A. Boppart, “Multimodal in vivo skin imaging with integrated optical coherence and multiphoton microscopy,” IEEE J. Sel. Top. Quantum Electron.18(4), 1280–1286 (2012).
[CrossRef]

K.-S. Lee, H. Zhao, S. F. Ibrahim, N. Meemon, L. Khoudeir, and J. P. Rolland, “Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy,” J. Biomed. Opt.17(12), 126006 (2012).
[CrossRef] [PubMed]

V. J. Srinivasan, H. Radhakrishnan, J. Y. Jiang, S. Barry, and A. E. Cable, “Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast,” Opt. Express20(3), 2220–2239 (2012).
[CrossRef] [PubMed]

2011 (3)

2010 (9)

S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
[CrossRef] [PubMed]

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther.10(5), 438–447 (2010).
[CrossRef] [PubMed]

A. D. Aguirre, Y. Chen, B. Bryan, H. Mashimo, Q. Huang, J. L. Connolly, and J. G. Fujimoto, “Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy,” J. Biomed. Opt.15(1), 016025 (2010).
[CrossRef] [PubMed]

C. Zhou, Y. H. Wang, A. D. Aguirre, T. H. Tsai, D. W. Cohen, J. L. Connolly, and J. G. Fujimoto, “Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy,” J. Biomed. Opt.15(1), 016001 (2010).
[CrossRef] [PubMed]

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res.70(24), 10071–10079 (2010).
[CrossRef] [PubMed]

J. P. Rolland, P. Meemon, S. Murali, K. P. Thompson, and K.-S. Lee, “Gabor-based fusion technique for optical coherence microscopy,” Opt. Express18(4), 3632–3642 (2010).
[CrossRef] [PubMed]

A. D. Aguirre, J. Sawinski, S.-W. Huang, C. Zhou, W. Denk, and J. G. Fujimoto, “High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe,” Opt. Express18(5), 4222–4239 (2010).
[CrossRef] [PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express18(14), 14685–14704 (2010).
[CrossRef] [PubMed]

B. W. Graf, S. G. Adie, and S. A. Boppart, “Correction of coherence gate curvature in high numerical aperture optical coherence imaging,” Opt. Lett.35(18), 3120–3122 (2010).
[CrossRef] [PubMed]

2009 (1)

B. W. Graf, Z. Jiang, H. H. Tu, and S. A. Boppart, “Dual-spectrum laser source based on fiber continuum generation for integrated optical coherence and multiphoton microscopy,” J. Biomed. Opt.14(3), 034019 (2009).
[CrossRef] [PubMed]

2008 (4)

2007 (4)

2006 (5)

2005 (2)

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, “Deconvolution methods for mitigation of transverse blurring in optical coherence tomography,” IEEE Trans. Image Process.14(9), 1254–1264 (2005).
[CrossRef] [PubMed]

M. A. Choma, A. K. Ellerbee, C. H. Yang, T. L. Creazzo, and J. A. Izatt, “Spectral-domain phase microscopy,” Opt. Lett.30(10), 1162–1164 (2005).
[CrossRef] [PubMed]

2004 (2)

2003 (4)

2002 (1)

2001 (1)

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med.7(4), 502–507 (2001).
[CrossRef] [PubMed]

2000 (1)

C. Pitris, C. Jesser, S. A. Boppart, D. Stamper, M. E. Brezinski, and J. G. Fujimoto, “Feasibility of optical coherence tomography for high-resolution imaging of human gastrointestinal tract malignancies,” J. Gastroenterol.35(2), 87–92 (2000).
[CrossRef] [PubMed]

1996 (1)

1994 (1)

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Adie, S. G.

Adler, D. C.

Aguirre, A. D.

H.-C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y. Sheikine, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues,” J. Urol.187(2), 691–699 (2012).
[CrossRef] [PubMed]

C. Zhou, Y. H. Wang, A. D. Aguirre, T. H. Tsai, D. W. Cohen, J. L. Connolly, and J. G. Fujimoto, “Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy,” J. Biomed. Opt.15(1), 016001 (2010).
[CrossRef] [PubMed]

A. D. Aguirre, J. Sawinski, S.-W. Huang, C. Zhou, W. Denk, and J. G. Fujimoto, “High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe,” Opt. Express18(5), 4222–4239 (2010).
[CrossRef] [PubMed]

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res.70(24), 10071–10079 (2010).
[CrossRef] [PubMed]

A. D. Aguirre, Y. Chen, B. Bryan, H. Mashimo, Q. Huang, J. L. Connolly, and J. G. Fujimoto, “Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy,” J. Biomed. Opt.15(1), 016025 (2010).
[CrossRef] [PubMed]

S.-W. Huang, A. D. Aguirre, R. A. Huber, D. C. Adler, and J. G. Fujimoto, “Swept source optical coherence microscopy using a Fourier domain mode-locked laser,” Opt. Express15(10), 6210–6217 (2007).
[CrossRef] [PubMed]

An, L.

Bachmann, A. H.

Barry, S.

Barton, J. K.

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther.10(5), 438–447 (2010).
[CrossRef] [PubMed]

A. R. Tumlinson, J. K. Barton, B. Povazay, H. Sattman, A. Unterhuber, R. A. Leitgeb, and W. Drexler, “Endoscope-tip interferometer for ultrahigh resolution frequency domain optical coherence tomography in mouse colon,” Opt. Express14(5), 1878–1887 (2006).
[CrossRef] [PubMed]

Biedermann, B. R.

Blatter, C.

Boppart, S. A.

B. W. Graf and S. A. Boppart, “Multimodal in vivo skin imaging with integrated optical coherence and multiphoton microscopy,” IEEE J. Sel. Top. Quantum Electron.18(4), 1280–1286 (2012).
[CrossRef]

B. W. Graf, S. G. Adie, and S. A. Boppart, “Correction of coherence gate curvature in high numerical aperture optical coherence imaging,” Opt. Lett.35(18), 3120–3122 (2010).
[CrossRef] [PubMed]

B. W. Graf, Z. Jiang, H. H. Tu, and S. A. Boppart, “Dual-spectrum laser source based on fiber continuum generation for integrated optical coherence and multiphoton microscopy,” J. Biomed. Opt.14(3), 034019 (2009).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys.3(2), 129–134 (2007).
[CrossRef]

C. Y. Xu, C. Vinegoni, T. S. Ralston, W. Luo, W. Tan, and S. A. Boppart, “Spectroscopic spectral-domain optical coherence microscopy,” Opt. Lett.31(8), 1079–1081 (2006).
[CrossRef] [PubMed]

C. Vinegoni, T. Ralston, W. Tan, W. Luo, D. L. Marks, and S. A. Boppart, “Integrated structural and functional optical imaging combining spectral-domain optical coherence and multiphoton microscopy,” Appl. Phys. Lett.88(5), 053901 (2006).
[CrossRef]

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, “Deconvolution methods for mitigation of transverse blurring in optical coherence tomography,” IEEE Trans. Image Process.14(9), 1254–1264 (2005).
[CrossRef] [PubMed]

C. Pitris, C. Jesser, S. A. Boppart, D. Stamper, M. E. Brezinski, and J. G. Fujimoto, “Feasibility of optical coherence tomography for high-resolution imaging of human gastrointestinal tract malignancies,” J. Gastroenterol.35(2), 87–92 (2000).
[CrossRef] [PubMed]

Bouma, B.

Bouma, B. E.

L. B. Liu, J. A. Gardecki, S. K. Nadkarni, J. D. Toussaint, Y. Yagi, B. E. Bouma, and G. J. Tearney, “Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography,” Nat. Med.17(8), 1010–1014 (2011).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, “Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography,” Opt. Lett.28(21), 2067–2069 (2003).
[CrossRef] [PubMed]

Brewer, M. A.

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther.10(5), 438–447 (2010).
[CrossRef] [PubMed]

Brezinski, M. E.

C. Pitris, C. Jesser, S. A. Boppart, D. Stamper, M. E. Brezinski, and J. G. Fujimoto, “Feasibility of optical coherence tomography for high-resolution imaging of human gastrointestinal tract malignancies,” J. Gastroenterol.35(2), 87–92 (2000).
[CrossRef] [PubMed]

Bryan, B.

A. D. Aguirre, Y. Chen, B. Bryan, H. Mashimo, Q. Huang, J. L. Connolly, and J. G. Fujimoto, “Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy,” J. Biomed. Opt.15(1), 016025 (2010).
[CrossRef] [PubMed]

Cable, A.

V. Jayaraman, G. D. Cole, M. Robertson, A. Uddin, and A. Cable, “High-sweep-rate 1310 nm MEMS-VCSEL with 150 nm continuous tuning range,” Electron. Lett.48(14), 867–868 (2012).
[CrossRef]

S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
[CrossRef] [PubMed]

B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. L. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express16(19), 15149–15169 (2008).
[CrossRef] [PubMed]

Cable, A. E.

Carney, P. S.

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys.3(2), 129–134 (2007).
[CrossRef]

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Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

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S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
[CrossRef] [PubMed]

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Chen, T. C.

Chen, Y.

A. D. Aguirre, Y. Chen, B. Bryan, H. Mashimo, Q. Huang, J. L. Connolly, and J. G. Fujimoto, “Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy,” J. Biomed. Opt.15(1), 016025 (2010).
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S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
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Chen, Z.

Chen, Z. P.

Choma, M. A.

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H.-C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y. Sheikine, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues,” J. Urol.187(2), 691–699 (2012).
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C. Zhou, Y. H. Wang, A. D. Aguirre, T. H. Tsai, D. W. Cohen, J. L. Connolly, and J. G. Fujimoto, “Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy,” J. Biomed. Opt.15(1), 016001 (2010).
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C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res.70(24), 10071–10079 (2010).
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V. Jayaraman, G. D. Cole, M. Robertson, A. Uddin, and A. Cable, “High-sweep-rate 1310 nm MEMS-VCSEL with 150 nm continuous tuning range,” Electron. Lett.48(14), 867–868 (2012).
[CrossRef]

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H.-C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y. Sheikine, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues,” J. Urol.187(2), 691–699 (2012).
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C. Zhou, Y. H. Wang, A. D. Aguirre, T. H. Tsai, D. W. Cohen, J. L. Connolly, and J. G. Fujimoto, “Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy,” J. Biomed. Opt.15(1), 016001 (2010).
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C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res.70(24), 10071–10079 (2010).
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A. D. Aguirre, Y. Chen, B. Bryan, H. Mashimo, Q. Huang, J. L. Connolly, and J. G. Fujimoto, “Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy,” J. Biomed. Opt.15(1), 016025 (2010).
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Davis, J. R.

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther.10(5), 438–447 (2010).
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D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
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H.-C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y. Sheikine, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues,” J. Urol.187(2), 691–699 (2012).
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C. Zhou, Y. H. Wang, A. D. Aguirre, T. H. Tsai, D. W. Cohen, J. L. Connolly, and J. G. Fujimoto, “Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy,” J. Biomed. Opt.15(1), 016001 (2010).
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A. D. Aguirre, Y. Chen, B. Bryan, H. Mashimo, Q. Huang, J. L. Connolly, and J. G. Fujimoto, “Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy,” J. Biomed. Opt.15(1), 016025 (2010).
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B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. L. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express16(19), 15149–15169 (2008).
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S.-W. Huang, A. D. Aguirre, R. A. Huber, D. C. Adler, and J. G. Fujimoto, “Swept source optical coherence microscopy using a Fourier domain mode-locked laser,” Opt. Express15(10), 6210–6217 (2007).
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T. H. Ko, D. C. Adler, J. G. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, and S. Yakubovich, “Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source,” Opt. Express12(10), 2112–2119 (2004).
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C. Pitris, C. Jesser, S. A. Boppart, D. Stamper, M. E. Brezinski, and J. G. Fujimoto, “Feasibility of optical coherence tomography for high-resolution imaging of human gastrointestinal tract malignancies,” J. Gastroenterol.35(2), 87–92 (2000).
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J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, “Optical coherence microscopy in scattering media,” Opt. Lett.19(8), 590–592 (1994).
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Gardecki, J. A.

L. B. Liu, J. A. Gardecki, S. K. Nadkarni, J. D. Toussaint, Y. Yagi, B. E. Bouma, and G. J. Tearney, “Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography,” Nat. Med.17(8), 1010–1014 (2011).
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W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med.7(4), 502–507 (2001).
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B. W. Graf and S. A. Boppart, “Multimodal in vivo skin imaging with integrated optical coherence and multiphoton microscopy,” IEEE J. Sel. Top. Quantum Electron.18(4), 1280–1286 (2012).
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Grajciar, B.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
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Griffiths, G.

S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
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L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther.10(5), 438–447 (2010).
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J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, “Optical coherence microscopy in scattering media,” Opt. Lett.19(8), 590–592 (1994).
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L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther.10(5), 438–447 (2010).
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X. Qi, Y. Pan, Z. Hu, W. Kang, J. E. Willis, K. Olowe, M. V. Sivak, and A. M. Rollins, “Automated quantification of colonic crypt morphology using integrated microscopy and optical coherence tomography,” J. Biomed. Opt.13(5), 054055 (2008).
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D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

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A. D. Aguirre, Y. Chen, B. Bryan, H. Mashimo, Q. Huang, J. L. Connolly, and J. G. Fujimoto, “Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy,” J. Biomed. Opt.15(1), 016025 (2010).
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Huang, S.-W.

Huber, R.

Huber, R. A.

Ibrahim, S. F.

K.-S. Lee, H. Zhao, S. F. Ibrahim, N. Meemon, L. Khoudeir, and J. P. Rolland, “Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy,” J. Biomed. Opt.17(12), 126006 (2012).
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Izatt, J. A.

Jayaraman, V.

V. Jayaraman, G. D. Cole, M. Robertson, A. Uddin, and A. Cable, “High-sweep-rate 1310 nm MEMS-VCSEL with 150 nm continuous tuning range,” Electron. Lett.48(14), 867–868 (2012).
[CrossRef]

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C. Pitris, C. Jesser, S. A. Boppart, D. Stamper, M. E. Brezinski, and J. G. Fujimoto, “Feasibility of optical coherence tomography for high-resolution imaging of human gastrointestinal tract malignancies,” J. Gastroenterol.35(2), 87–92 (2000).
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S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
[CrossRef] [PubMed]

B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. L. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express16(19), 15149–15169 (2008).
[CrossRef] [PubMed]

Jiang, J. Y.

Jiang, Z.

B. W. Graf, Z. Jiang, H. H. Tu, and S. A. Boppart, “Dual-spectrum laser source based on fiber continuum generation for integrated optical coherence and multiphoton microscopy,” J. Biomed. Opt.14(3), 034019 (2009).
[CrossRef] [PubMed]

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T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, “Deconvolution methods for mitigation of transverse blurring in optical coherence tomography,” IEEE Trans. Image Process.14(9), 1254–1264 (2005).
[CrossRef] [PubMed]

Kang, W.

X. Qi, Y. Pan, Z. Hu, W. Kang, J. E. Willis, K. Olowe, M. V. Sivak, and A. M. Rollins, “Automated quantification of colonic crypt morphology using integrated microscopy and optical coherence tomography,” J. Biomed. Opt.13(5), 054055 (2008).
[CrossRef] [PubMed]

Kärtner, F. X.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med.7(4), 502–507 (2001).
[CrossRef] [PubMed]

Kempe, M.

Khoudeir, L.

K.-S. Lee, H. Zhao, S. F. Ibrahim, N. Meemon, L. Khoudeir, and J. P. Rolland, “Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy,” J. Biomed. Opt.17(12), 126006 (2012).
[CrossRef] [PubMed]

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Ko, T. H.

Lasser, T.

Lee, H.-C.

H.-C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y. Sheikine, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues,” J. Urol.187(2), 691–699 (2012).
[CrossRef] [PubMed]

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res.70(24), 10071–10079 (2010).
[CrossRef] [PubMed]

Lee, K. S.

Lee, K.-S.

K.-S. Lee, H. Zhao, S. F. Ibrahim, N. Meemon, L. Khoudeir, and J. P. Rolland, “Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy,” J. Biomed. Opt.17(12), 126006 (2012).
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J. P. Rolland, P. Meemon, S. Murali, K. P. Thompson, and K.-S. Lee, “Gabor-based fusion technique for optical coherence microscopy,” Opt. Express18(4), 3632–3642 (2010).
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Leitgeb, R. A.

Li, P.

Liebmann, E. R.

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther.10(5), 438–447 (2010).
[CrossRef] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Liu, C.

Liu, L.

Liu, L. B.

L. B. Liu, J. A. Gardecki, S. K. Nadkarni, J. D. Toussaint, Y. Yagi, B. E. Bouma, and G. J. Tearney, “Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography,” Nat. Med.17(8), 1010–1014 (2011).
[CrossRef] [PubMed]

Luo, W.

C. Vinegoni, T. Ralston, W. Tan, W. Luo, D. L. Marks, and S. A. Boppart, “Integrated structural and functional optical imaging combining spectral-domain optical coherence and multiphoton microscopy,” Appl. Phys. Lett.88(5), 053901 (2006).
[CrossRef]

C. Y. Xu, C. Vinegoni, T. S. Ralston, W. Luo, W. Tan, and S. A. Boppart, “Spectroscopic spectral-domain optical coherence microscopy,” Opt. Lett.31(8), 1079–1081 (2006).
[CrossRef] [PubMed]

Ma, H. Z.

S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
[CrossRef] [PubMed]

Makita, S.

Mamedov, D.

Marion, S. L.

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther.10(5), 438–447 (2010).
[CrossRef] [PubMed]

Marks, D. L.

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys.3(2), 129–134 (2007).
[CrossRef]

C. Vinegoni, T. Ralston, W. Tan, W. Luo, D. L. Marks, and S. A. Boppart, “Integrated structural and functional optical imaging combining spectral-domain optical coherence and multiphoton microscopy,” Appl. Phys. Lett.88(5), 053901 (2006).
[CrossRef]

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, “Deconvolution methods for mitigation of transverse blurring in optical coherence tomography,” IEEE Trans. Image Process.14(9), 1254–1264 (2005).
[CrossRef] [PubMed]

Mashimo, H.

A. D. Aguirre, Y. Chen, B. Bryan, H. Mashimo, Q. Huang, J. L. Connolly, and J. G. Fujimoto, “Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy,” J. Biomed. Opt.15(1), 016025 (2010).
[CrossRef] [PubMed]

Meemon, N.

K.-S. Lee, H. Zhao, S. F. Ibrahim, N. Meemon, L. Khoudeir, and J. P. Rolland, “Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy,” J. Biomed. Opt.17(12), 126006 (2012).
[CrossRef] [PubMed]

Meemon, P.

Mondelblatt, A. E.

H.-C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y. Sheikine, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues,” J. Urol.187(2), 691–699 (2012).
[CrossRef] [PubMed]

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res.70(24), 10071–10079 (2010).
[CrossRef] [PubMed]

Morgner, U.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med.7(4), 502–507 (2001).
[CrossRef] [PubMed]

Murali, S.

Nadkarni, S. K.

L. B. Liu, J. A. Gardecki, S. K. Nadkarni, J. D. Toussaint, Y. Yagi, B. E. Bouma, and G. J. Tearney, “Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography,” Nat. Med.17(8), 1010–1014 (2011).
[CrossRef] [PubMed]

Nakamura, Y.

Nassif, N.

Nelson, J. S.

Olowe, K.

X. Qi, Y. Pan, Z. Hu, W. Kang, J. E. Willis, K. Olowe, M. V. Sivak, and A. M. Rollins, “Automated quantification of colonic crypt morphology using integrated microscopy and optical coherence tomography,” J. Biomed. Opt.13(5), 054055 (2008).
[CrossRef] [PubMed]

Owen, G. M.

Pan, Y.

X. Qi, Y. Pan, Z. Hu, W. Kang, J. E. Willis, K. Olowe, M. V. Sivak, and A. M. Rollins, “Automated quantification of colonic crypt morphology using integrated microscopy and optical coherence tomography,” J. Biomed. Opt.13(5), 054055 (2008).
[CrossRef] [PubMed]

Park, B. H.

Pierce, M. C.

Pitris, C.

C. Pitris, C. Jesser, S. A. Boppart, D. Stamper, M. E. Brezinski, and J. G. Fujimoto, “Feasibility of optical coherence tomography for high-resolution imaging of human gastrointestinal tract malignancies,” J. Gastroenterol.35(2), 87–92 (2000).
[CrossRef] [PubMed]

Potsaid, B.

Povazay, B.

Prokhorov, V.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Qi, X.

X. Qi, Y. Pan, Z. Hu, W. Kang, J. E. Willis, K. Olowe, M. V. Sivak, and A. M. Rollins, “Automated quantification of colonic crypt morphology using integrated microscopy and optical coherence tomography,” J. Biomed. Opt.13(5), 054055 (2008).
[CrossRef] [PubMed]

Radhakrishnan, H.

Ralston, T.

C. Vinegoni, T. Ralston, W. Tan, W. Luo, D. L. Marks, and S. A. Boppart, “Integrated structural and functional optical imaging combining spectral-domain optical coherence and multiphoton microscopy,” Appl. Phys. Lett.88(5), 053901 (2006).
[CrossRef]

Ralston, T. S.

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys.3(2), 129–134 (2007).
[CrossRef]

C. Y. Xu, C. Vinegoni, T. S. Ralston, W. Luo, W. Tan, and S. A. Boppart, “Spectroscopic spectral-domain optical coherence microscopy,” Opt. Lett.31(8), 1079–1081 (2006).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, “Deconvolution methods for mitigation of transverse blurring in optical coherence tomography,” IEEE Trans. Image Process.14(9), 1254–1264 (2005).
[CrossRef] [PubMed]

Rao, B.

Ren, H.

Robertson, M.

V. Jayaraman, G. D. Cole, M. Robertson, A. Uddin, and A. Cable, “High-sweep-rate 1310 nm MEMS-VCSEL with 150 nm continuous tuning range,” Electron. Lett.48(14), 867–868 (2012).
[CrossRef]

Rolland, J. P.

Rollins, A. M.

X. Qi, Y. Pan, Z. Hu, W. Kang, J. E. Willis, K. Olowe, M. V. Sivak, and A. M. Rollins, “Automated quantification of colonic crypt morphology using integrated microscopy and optical coherence tomography,” J. Biomed. Opt.13(5), 054055 (2008).
[CrossRef] [PubMed]

Roney, C. A.

S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
[CrossRef] [PubMed]

Rudolph, W.

Sando, Y.

Sarunic, M. V.

Sattman, H.

Sawinski, J.

Schellenberg, M.

H. Helmers and M. Schellenberg, “CMOS vs. CCD sensors in speckle interferometry,” Opt. Laser Technol.35(8), 587–595 (2003).
[CrossRef]

Schuman, J. S.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med.7(4), 502–507 (2001).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Sheikine, Y.

H.-C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y. Sheikine, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues,” J. Urol.187(2), 691–699 (2012).
[CrossRef] [PubMed]

Shen, D.

H.-C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y. Sheikine, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues,” J. Urol.187(2), 691–699 (2012).
[CrossRef] [PubMed]

Shen, T. T.

Sheppard, C. J. R.

Shidlovski, V.

Sivak, M. V.

X. Qi, Y. Pan, Z. Hu, W. Kang, J. E. Willis, K. Olowe, M. V. Sivak, and A. M. Rollins, “Automated quantification of colonic crypt morphology using integrated microscopy and optical coherence tomography,” J. Biomed. Opt.13(5), 054055 (2008).
[CrossRef] [PubMed]

Srinivasan, V. J.

Stamper, D.

C. Pitris, C. Jesser, S. A. Boppart, D. Stamper, M. E. Brezinski, and J. G. Fujimoto, “Feasibility of optical coherence tomography for high-resolution imaging of human gastrointestinal tract malignancies,” J. Gastroenterol.35(2), 87–92 (2000).
[CrossRef] [PubMed]

Steinmann, L.

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Su, J. P.

Sugisaka, J. I.

Summers, R. M.

S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
[CrossRef] [PubMed]

Swanson, E. A.

J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, “Optical coherence microscopy in scattering media,” Opt. Lett.19(8), 590–592 (1994).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Tan, W.

C. Vinegoni, T. Ralston, W. Tan, W. Luo, D. L. Marks, and S. A. Boppart, “Integrated structural and functional optical imaging combining spectral-domain optical coherence and multiphoton microscopy,” Appl. Phys. Lett.88(5), 053901 (2006).
[CrossRef]

C. Y. Xu, C. Vinegoni, T. S. Ralston, W. Luo, W. Tan, and S. A. Boppart, “Spectroscopic spectral-domain optical coherence microscopy,” Opt. Lett.31(8), 1079–1081 (2006).
[CrossRef] [PubMed]

Tearney, G.

Tearney, G. J.

L. B. Liu, J. A. Gardecki, S. K. Nadkarni, J. D. Toussaint, Y. Yagi, B. E. Bouma, and G. J. Tearney, “Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography,” Nat. Med.17(8), 1010–1014 (2011).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, “Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography,” Opt. Lett.28(21), 2067–2069 (2003).
[CrossRef] [PubMed]

Thompson, K. P.

Toussaint, J. D.

L. B. Liu, J. A. Gardecki, S. K. Nadkarni, J. D. Toussaint, Y. Yagi, B. E. Bouma, and G. J. Tearney, “Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography,” Nat. Med.17(8), 1010–1014 (2011).
[CrossRef] [PubMed]

Tsai, T. H.

C. Zhou, Y. H. Wang, A. D. Aguirre, T. H. Tsai, D. W. Cohen, J. L. Connolly, and J. G. Fujimoto, “Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy,” J. Biomed. Opt.15(1), 016001 (2010).
[CrossRef] [PubMed]

Tsai, T.-H.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res.70(24), 10071–10079 (2010).
[CrossRef] [PubMed]

Tu, H. H.

B. W. Graf, Z. Jiang, H. H. Tu, and S. A. Boppart, “Dual-spectrum laser source based on fiber continuum generation for integrated optical coherence and multiphoton microscopy,” J. Biomed. Opt.14(3), 034019 (2009).
[CrossRef] [PubMed]

Tumlinson, A. R.

Uddin, A.

V. Jayaraman, G. D. Cole, M. Robertson, A. Uddin, and A. Cable, “High-sweep-rate 1310 nm MEMS-VCSEL with 150 nm continuous tuning range,” Electron. Lett.48(14), 867–868 (2012).
[CrossRef]

Unterhuber, A.

Villiger, M.

Vinegoni, C.

C. Y. Xu, C. Vinegoni, T. S. Ralston, W. Luo, W. Tan, and S. A. Boppart, “Spectroscopic spectral-domain optical coherence microscopy,” Opt. Lett.31(8), 1079–1081 (2006).
[CrossRef] [PubMed]

C. Vinegoni, T. Ralston, W. Tan, W. Luo, D. L. Marks, and S. A. Boppart, “Integrated structural and functional optical imaging combining spectral-domain optical coherence and multiphoton microscopy,” Appl. Phys. Lett.88(5), 053901 (2006).
[CrossRef]

Wang, Q.

Wang, R. K.

Wang, Y.

H.-C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y. Sheikine, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues,” J. Urol.187(2), 691–699 (2012).
[CrossRef] [PubMed]

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res.70(24), 10071–10079 (2010).
[CrossRef] [PubMed]

Wang, Y. H.

C. Zhou, Y. H. Wang, A. D. Aguirre, T. H. Tsai, D. W. Cohen, J. L. Connolly, and J. G. Fujimoto, “Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy,” J. Biomed. Opt.15(1), 016001 (2010).
[CrossRef] [PubMed]

Welsch, E.

Wierwille, J.

S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
[CrossRef] [PubMed]

Wieser, W.

Willis, J. E.

X. Qi, Y. Pan, Z. Hu, W. Kang, J. E. Willis, K. Olowe, M. V. Sivak, and A. M. Rollins, “Automated quantification of colonic crypt morphology using integrated microscopy and optical coherence tomography,” J. Biomed. Opt.13(5), 054055 (2008).
[CrossRef] [PubMed]

Xu, B. Y.

S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
[CrossRef] [PubMed]

Xu, C. Y.

Yagi, Y.

L. B. Liu, J. A. Gardecki, S. K. Nadkarni, J. D. Toussaint, Y. Yagi, B. E. Bouma, and G. J. Tearney, “Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography,” Nat. Med.17(8), 1010–1014 (2011).
[CrossRef] [PubMed]

Yakubovich, S.

Yang, C. H.

Yasuno, Y.

Yatagai, T.

Yu, L. F.

Yuan, S. A.

S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
[CrossRef] [PubMed]

Yun, S. H.

Zhang, J.

Zhao, H.

K.-S. Lee, H. Zhao, S. F. Ibrahim, N. Meemon, L. Khoudeir, and J. P. Rolland, “Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy,” J. Biomed. Opt.17(12), 126006 (2012).
[CrossRef] [PubMed]

Zhao, Y.

Zhou, C.

H.-C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y. Sheikine, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues,” J. Urol.187(2), 691–699 (2012).
[CrossRef] [PubMed]

C. Zhou, Y. H. Wang, A. D. Aguirre, T. H. Tsai, D. W. Cohen, J. L. Connolly, and J. G. Fujimoto, “Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy,” J. Biomed. Opt.15(1), 016001 (2010).
[CrossRef] [PubMed]

A. D. Aguirre, J. Sawinski, S.-W. Huang, C. Zhou, W. Denk, and J. G. Fujimoto, “High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe,” Opt. Express18(5), 4222–4239 (2010).
[CrossRef] [PubMed]

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res.70(24), 10071–10079 (2010).
[CrossRef] [PubMed]

Appl. Phys. Lett. (1)

C. Vinegoni, T. Ralston, W. Tan, W. Luo, D. L. Marks, and S. A. Boppart, “Integrated structural and functional optical imaging combining spectral-domain optical coherence and multiphoton microscopy,” Appl. Phys. Lett.88(5), 053901 (2006).
[CrossRef]

Biomed. Opt. Express (1)

Cancer Biol. Ther. (1)

L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther.10(5), 438–447 (2010).
[CrossRef] [PubMed]

Cancer Res. (1)

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res.70(24), 10071–10079 (2010).
[CrossRef] [PubMed]

Electron. Lett. (1)

V. Jayaraman, G. D. Cole, M. Robertson, A. Uddin, and A. Cable, “High-sweep-rate 1310 nm MEMS-VCSEL with 150 nm continuous tuning range,” Electron. Lett.48(14), 867–868 (2012).
[CrossRef]

IEEE J. Sel. Top. Quantum Electron. (1)

B. W. Graf and S. A. Boppart, “Multimodal in vivo skin imaging with integrated optical coherence and multiphoton microscopy,” IEEE J. Sel. Top. Quantum Electron.18(4), 1280–1286 (2012).
[CrossRef]

IEEE Trans. Image Process. (1)

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, “Deconvolution methods for mitigation of transverse blurring in optical coherence tomography,” IEEE Trans. Image Process.14(9), 1254–1264 (2005).
[CrossRef] [PubMed]

J. Biomed. Opt. (5)

A. D. Aguirre, Y. Chen, B. Bryan, H. Mashimo, Q. Huang, J. L. Connolly, and J. G. Fujimoto, “Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy,” J. Biomed. Opt.15(1), 016025 (2010).
[CrossRef] [PubMed]

C. Zhou, Y. H. Wang, A. D. Aguirre, T. H. Tsai, D. W. Cohen, J. L. Connolly, and J. G. Fujimoto, “Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy,” J. Biomed. Opt.15(1), 016001 (2010).
[CrossRef] [PubMed]

B. W. Graf, Z. Jiang, H. H. Tu, and S. A. Boppart, “Dual-spectrum laser source based on fiber continuum generation for integrated optical coherence and multiphoton microscopy,” J. Biomed. Opt.14(3), 034019 (2009).
[CrossRef] [PubMed]

K.-S. Lee, H. Zhao, S. F. Ibrahim, N. Meemon, L. Khoudeir, and J. P. Rolland, “Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy,” J. Biomed. Opt.17(12), 126006 (2012).
[CrossRef] [PubMed]

X. Qi, Y. Pan, Z. Hu, W. Kang, J. E. Willis, K. Olowe, M. V. Sivak, and A. M. Rollins, “Automated quantification of colonic crypt morphology using integrated microscopy and optical coherence tomography,” J. Biomed. Opt.13(5), 054055 (2008).
[CrossRef] [PubMed]

J. Gastroenterol. (1)

C. Pitris, C. Jesser, S. A. Boppart, D. Stamper, M. E. Brezinski, and J. G. Fujimoto, “Feasibility of optical coherence tomography for high-resolution imaging of human gastrointestinal tract malignancies,” J. Gastroenterol.35(2), 87–92 (2000).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (1)

J. Urol. (1)

H.-C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y. Sheikine, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues,” J. Urol.187(2), 691–699 (2012).
[CrossRef] [PubMed]

Nat. Med. (2)

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med.7(4), 502–507 (2001).
[CrossRef] [PubMed]

L. B. Liu, J. A. Gardecki, S. K. Nadkarni, J. D. Toussaint, Y. Yagi, B. E. Bouma, and G. J. Tearney, “Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography,” Nat. Med.17(8), 1010–1014 (2011).
[CrossRef] [PubMed]

Nat. Phys. (1)

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys.3(2), 129–134 (2007).
[CrossRef]

Opt. Express (15)

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, “Performance of Fourier domain vs. time domain optical coherence tomography,” Opt. Express11(8), 889–894 (2003).
[CrossRef] [PubMed]

M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, “Sensitivity advantage of swept source and Fourier domain optical coherence tomography,” Opt. Express11(18), 2183–2189 (2003).
[CrossRef] [PubMed]

T. H. Ko, D. C. Adler, J. G. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, and S. Yakubovich, “Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source,” Opt. Express12(10), 2112–2119 (2004).
[CrossRef] [PubMed]

B. Cense, N. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. Bouma, G. Tearney, and J. F. de Boer, “Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography,” Opt. Express12(11), 2435–2447 (2004).
[CrossRef] [PubMed]

Y. Yasuno, J. I. Sugisaka, Y. Sando, Y. Nakamura, S. Makita, M. Itoh, and T. Yatagai, “Non-iterative numerical method for laterally superresolving Fourier domain optical coherence tomography,” Opt. Express14(3), 1006–1020 (2006).
[CrossRef] [PubMed]

A. R. Tumlinson, J. K. Barton, B. Povazay, H. Sattman, A. Unterhuber, R. A. Leitgeb, and W. Drexler, “Endoscope-tip interferometer for ultrahigh resolution frequency domain optical coherence tomography in mouse colon,” Opt. Express14(5), 1878–1887 (2006).
[CrossRef] [PubMed]

S.-W. Huang, A. D. Aguirre, R. A. Huber, D. C. Adler, and J. G. Fujimoto, “Swept source optical coherence microscopy using a Fourier domain mode-locked laser,” Opt. Express15(10), 6210–6217 (2007).
[CrossRef] [PubMed]

L. F. Yu, B. Rao, J. Zhang, J. P. Su, Q. Wang, S. G. Guo, and Z. P. Chen, “Improved lateral resolution in optical coherence tomography by digital focusing using two-dimensional numerical diffraction method,” Opt. Express15(12), 7634–7641 (2007).
[CrossRef] [PubMed]

S. Makita, T. Fabritius, and Y. Yasuno, “Full-range, high-speed, high-resolution 1 microm spectral-domain optical coherence tomography using BM-scan for volumetric imaging of the human posterior eye,” Opt. Express16(12), 8406–8420 (2008).
[CrossRef] [PubMed]

C. Blatter, B. Grajciar, C. M. Eigenwillig, W. Wieser, B. R. Biedermann, R. Huber, and R. A. Leitgeb, “Extended focus high-speed swept source OCT with self-reconstructive illumination,” Opt. Express19(13), 12141–12155 (2011).
[CrossRef] [PubMed]

V. J. Srinivasan, H. Radhakrishnan, J. Y. Jiang, S. Barry, and A. E. Cable, “Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast,” Opt. Express20(3), 2220–2239 (2012).
[CrossRef] [PubMed]

B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. L. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express16(19), 15149–15169 (2008).
[CrossRef] [PubMed]

J. P. Rolland, P. Meemon, S. Murali, K. P. Thompson, and K.-S. Lee, “Gabor-based fusion technique for optical coherence microscopy,” Opt. Express18(4), 3632–3642 (2010).
[CrossRef] [PubMed]

A. D. Aguirre, J. Sawinski, S.-W. Huang, C. Zhou, W. Denk, and J. G. Fujimoto, “High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe,” Opt. Express18(5), 4222–4239 (2010).
[CrossRef] [PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express18(14), 14685–14704 (2010).
[CrossRef] [PubMed]

Opt. Laser Technol. (1)

H. Helmers and M. Schellenberg, “CMOS vs. CCD sensors in speckle interferometry,” Opt. Laser Technol.35(8), 587–595 (2003).
[CrossRef]

Opt. Lett. (9)

J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, “Optical coherence microscopy in scattering media,” Opt. Lett.19(8), 590–592 (1994).
[CrossRef] [PubMed]

K. S. Lee and J. P. Rolland, “Bessel beam spectral-domain high-resolution optical coherence tomography with micro-optic axicon providing extended focusing range,” Opt. Lett.33(15), 1696–1698 (2008).
[CrossRef] [PubMed]

L. Liu, C. Liu, W. C. Howe, C. J. R. Sheppard, and N. Chen, “Binary-phase spatial filter for real-time swept-source optical coherence microscopy,” Opt. Lett.32(16), 2375–2377 (2007).
[CrossRef] [PubMed]

C. Y. Xu, C. Vinegoni, T. S. Ralston, W. Luo, W. Tan, and S. A. Boppart, “Spectroscopic spectral-domain optical coherence microscopy,” Opt. Lett.31(8), 1079–1081 (2006).
[CrossRef] [PubMed]

R. A. Leitgeb, M. Villiger, A. H. Bachmann, L. Steinmann, and T. Lasser, “Extended focus depth for Fourier domain optical coherence microscopy,” Opt. Lett.31(16), 2450–2452 (2006).
[CrossRef] [PubMed]

M. A. Choma, A. K. Ellerbee, C. H. Yang, T. L. Creazzo, and J. A. Izatt, “Spectral-domain phase microscopy,” Opt. Lett.30(10), 1162–1164 (2005).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, “Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography,” Opt. Lett.28(21), 2067–2069 (2003).
[CrossRef] [PubMed]

Z. Ding, H. Ren, Y. Zhao, J. S. Nelson, and Z. Chen, “High-resolution optical coherence tomography over a large depth range with an axicon lens,” Opt. Lett.27(4), 243–245 (2002).
[CrossRef] [PubMed]

B. W. Graf, S. G. Adie, and S. A. Boppart, “Correction of coherence gate curvature in high numerical aperture optical coherence imaging,” Opt. Lett.35(18), 3120–3122 (2010).
[CrossRef] [PubMed]

Phys. Med. Biol. (1)

S. A. Yuan, C. A. Roney, J. Wierwille, C. W. Chen, B. Y. Xu, G. Griffiths, J. Jiang, H. Z. Ma, A. Cable, R. M. Summers, and Y. Chen, “Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging,” Phys. Med. Biol.55(1), 191–206 (2010).
[CrossRef] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

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