Abstract

In this paper, a logistic prediction model is introduced to characterize the ovarian tissue. A new parameter, the phase retardation rate, was extracted from phase images of polarization-sensitive optical coherence tomography (PS-OCT). Statistical significance of this parameter between normal and malignant ovarian tissues was demonstrated (p<0.0001). Linear regression analysis showed that this parameter was positively correlated (R = 0.74) with collagen content, which was associated with the development of ovarian tissue malignancy. When this parameter and the optical scattering coefficient and the phase retardation estimated from the 33 ovaries were used as input predictors to the logistic model, 100% sensitivity and specificity in classifying malignant and normal ovaries were achieved. Ten additional ovaries were imaged and used to validate the prediction model and 100% sensitivity and 83.3% specificity were achieved. These results showed that the three-parameter prediction model based on quantitative parameters estimated from PS-OCT images could be a powerful tool to detect and diagnose ovarian cancer.

© 2013 OSA

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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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2012

2011

Y. Yang, T. Wang, N. C. Biswal, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue,” J. Biomed. Opt.16(9), 090504 (2011).
[CrossRef] [PubMed]

X. Robin, N. Turck, A. Hainard, N. Tiberti, F. Lisacek, J. C. Sanchez, and M. Müller, “pROC: an open-source package for R and S+ to analyze and compare ROC curves,” BMC Bioinformatics12(1), 77 (2011).
[CrossRef] [PubMed]

2006

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol.7(10), 821–828 (2006).
[CrossRef] [PubMed]

2005

2004

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

M. C. Pierce, R. L. Sheridan, B. Hyle Park, B. Cense, and J. F. de Boer, “Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography,” Burns30(6), 511–517 (2004).
[CrossRef] [PubMed]

2002

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

1997

1992

1991

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Barakat, R. R.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Barton, J. K.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Biswal, N. C.

Y. Yang, T. Wang, N. C. Biswal, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue,” J. Biomed. Opt.16(9), 090504 (2011).
[CrossRef] [PubMed]

Borgen, P. I.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Boyd, J.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Brands, W. R.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Brewer, M.

Y. Yang, T. Wang, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Quantitative analysis of estimated scattering coefficient and phase retardation for ovarian tissue characterization,” Biomed. Opt. Express3(7), 1548–1556 (2012).
[CrossRef] [PubMed]

Y. Yang, T. Wang, N. C. Biswal, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue,” J. Biomed. Opt.16(9), 090504 (2011).
[CrossRef] [PubMed]

Brewer, M. A.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Castiel, M.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Cense, B.

M. C. Pierce, R. L. Sheridan, B. Hyle Park, B. Cense, and J. F. de Boer, “Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography,” Burns30(6), 511–517 (2004).
[CrossRef] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Chen, Y.

Daly, M. B.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Davis, J. R.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

de Andrade, M.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol.7(10), 821–828 (2006).
[CrossRef] [PubMed]

de Boer, J. F.

M. C. Pierce, R. L. Sheridan, B. Hyle Park, B. Cense, and J. F. de Boer, “Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography,” Burns30(6), 511–517 (2004).
[CrossRef] [PubMed]

J. F. de Boer, T. E. Milner, M. J. C. van Gemert, and J. S. Nelson, “Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography,” Opt. Lett.22(12), 934–936 (1997).
[CrossRef] [PubMed]

Ellis, N. A.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Evans, G.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Fujimoto, J. G.

M. R. Hee, D. Huang, E. A. Swanson, and J. G. Fujimoto, “Polarization-sensitive low-coherence reflectometer for birefringence characterization and ranging,” J. Opt. Soc. Am. B9(6), 903–908 (1992).
[CrossRef]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Garber, J. E.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Gmitro, A. F.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Grossardt, B. R.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol.7(10), 821–828 (2006).
[CrossRef] [PubMed]

Hainard, A.

X. Robin, N. Turck, A. Hainard, N. Tiberti, F. Lisacek, J. C. Sanchez, and M. Müller, “pROC: an open-source package for R and S+ to analyze and compare ROC curves,” BMC Bioinformatics12(1), 77 (2011).
[CrossRef] [PubMed]

Hee, M. R.

M. R. Hee, D. Huang, E. A. Swanson, and J. G. Fujimoto, “Polarization-sensitive low-coherence reflectometer for birefringence characterization and ranging,” J. Opt. Soc. Am. B9(6), 903–908 (1992).
[CrossRef]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hensley, M.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Hoying, J. B.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Huang, D.

M. R. Hee, D. Huang, E. A. Swanson, and J. G. Fujimoto, “Polarization-sensitive low-coherence reflectometer for birefringence characterization and ranging,” J. Opt. Soc. Am. B9(6), 903–908 (1992).
[CrossRef]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hudis, C. A.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Hunt, K.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Hyle Park, B.

M. C. Pierce, R. L. Sheridan, B. Hyle Park, B. Cense, and J. F. de Boer, “Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography,” Burns30(6), 511–517 (2004).
[CrossRef] [PubMed]

Isaacs, C.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Kauff, N. D.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Kirkpatrick, N. D.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Lisacek, F.

X. Robin, N. Turck, A. Hainard, N. Tiberti, F. Lisacek, J. C. Sanchez, and M. Müller, “pROC: an open-source package for R and S+ to analyze and compare ROC curves,” BMC Bioinformatics12(1), 77 (2011).
[CrossRef] [PubMed]

Lynch, H. T.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Malkasian, G. D.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol.7(10), 821–828 (2006).
[CrossRef] [PubMed]

Matloff, E.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Melton, L. J.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol.7(10), 821–828 (2006).
[CrossRef] [PubMed]

Milner, T. E.

Müller, M.

X. Robin, N. Turck, A. Hainard, N. Tiberti, F. Lisacek, J. C. Sanchez, and M. Müller, “pROC: an open-source package for R and S+ to analyze and compare ROC curves,” BMC Bioinformatics12(1), 77 (2011).
[CrossRef] [PubMed]

Nafa, K.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Narod, S. A.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Nelson, J. S.

Neuhausen, S. L.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Norton, L.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Offit, K.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Olopade, O. I.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Otis, L.

Piao, D.

Pierce, M. C.

M. C. Pierce, R. L. Sheridan, B. Hyle Park, B. Cense, and J. F. de Boer, “Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography,” Burns30(6), 511–517 (2004).
[CrossRef] [PubMed]

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Rebbeck, T. R.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Robin, X.

X. Robin, N. Turck, A. Hainard, N. Tiberti, F. Lisacek, J. C. Sanchez, and M. Müller, “pROC: an open-source package for R and S+ to analyze and compare ROC curves,” BMC Bioinformatics12(1), 77 (2011).
[CrossRef] [PubMed]

Robson, M. E.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Rocca, W. A.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol.7(10), 821–828 (2006).
[CrossRef] [PubMed]

Sanchez, J. C.

X. Robin, N. Turck, A. Hainard, N. Tiberti, F. Lisacek, J. C. Sanchez, and M. Müller, “pROC: an open-source package for R and S+ to analyze and compare ROC curves,” BMC Bioinformatics12(1), 77 (2011).
[CrossRef] [PubMed]

Sanders, M.

Y. Yang, T. Wang, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Quantitative analysis of estimated scattering coefficient and phase retardation for ovarian tissue characterization,” Biomed. Opt. Express3(7), 1548–1556 (2012).
[CrossRef] [PubMed]

Y. Yang, T. Wang, N. C. Biswal, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue,” J. Biomed. Opt.16(9), 090504 (2011).
[CrossRef] [PubMed]

Satagopan, J. M.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Scheuer, L.

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Sheridan, R. L.

M. C. Pierce, R. L. Sheridan, B. Hyle Park, B. Cense, and J. F. de Boer, “Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography,” Burns30(6), 511–517 (2004).
[CrossRef] [PubMed]

Stevens, S. J.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Swanson, E. A.

M. R. Hee, D. Huang, E. A. Swanson, and J. G. Fujimoto, “Polarization-sensitive low-coherence reflectometer for birefringence characterization and ranging,” J. Opt. Soc. Am. B9(6), 903–908 (1992).
[CrossRef]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Tiberti, N.

X. Robin, N. Turck, A. Hainard, N. Tiberti, F. Lisacek, J. C. Sanchez, and M. Müller, “pROC: an open-source package for R and S+ to analyze and compare ROC curves,” BMC Bioinformatics12(1), 77 (2011).
[CrossRef] [PubMed]

Turck, N.

X. Robin, N. Turck, A. Hainard, N. Tiberti, F. Lisacek, J. C. Sanchez, and M. Müller, “pROC: an open-source package for R and S+ to analyze and compare ROC curves,” BMC Bioinformatics12(1), 77 (2011).
[CrossRef] [PubMed]

Utzinger, U.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

van Gemert, M. J. C.

Van’t Veer, L.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Wang, T.

Y. Yang, T. Wang, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Quantitative analysis of estimated scattering coefficient and phase retardation for ovarian tissue characterization,” Biomed. Opt. Express3(7), 1548–1556 (2012).
[CrossRef] [PubMed]

Y. Yang, T. Wang, N. C. Biswal, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue,” J. Biomed. Opt.16(9), 090504 (2011).
[CrossRef] [PubMed]

Wang, X.

Y. Yang, T. Wang, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Quantitative analysis of estimated scattering coefficient and phase retardation for ovarian tissue characterization,” Biomed. Opt. Express3(7), 1548–1556 (2012).
[CrossRef] [PubMed]

Y. Yang, T. Wang, N. C. Biswal, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue,” J. Biomed. Opt.16(9), 090504 (2011).
[CrossRef] [PubMed]

Weber, B. L.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

Yang, Y.

Y. Yang, T. Wang, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Quantitative analysis of estimated scattering coefficient and phase retardation for ovarian tissue characterization,” Biomed. Opt. Express3(7), 1548–1556 (2012).
[CrossRef] [PubMed]

Y. Yang, T. Wang, N. C. Biswal, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue,” J. Biomed. Opt.16(9), 090504 (2011).
[CrossRef] [PubMed]

Zhu, Q.

Appl. Opt.

Biomed. Opt. Express

BMC Bioinformatics

X. Robin, N. Turck, A. Hainard, N. Tiberti, F. Lisacek, J. C. Sanchez, and M. Müller, “pROC: an open-source package for R and S+ to analyze and compare ROC curves,” BMC Bioinformatics12(1), 77 (2011).
[CrossRef] [PubMed]

Burns

M. C. Pierce, R. L. Sheridan, B. Hyle Park, B. Cense, and J. F. de Boer, “Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography,” Burns30(6), 511–517 (2004).
[CrossRef] [PubMed]

J. Biomed. Opt.

Y. Yang, T. Wang, N. C. Biswal, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue,” J. Biomed. Opt.16(9), 090504 (2011).
[CrossRef] [PubMed]

J. Opt. Soc. Am. B

Lancet Oncol.

W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol.7(10), 821–828 (2006).
[CrossRef] [PubMed]

N. Engl. J. Med.

T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med.346(21), 1616–1622 (2002).
[CrossRef] [PubMed]

N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med.346(21), 1609–1615 (2002).
[CrossRef] [PubMed]

Opt. Lett.

Science

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Technol. Cancer Res. Treat.

M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat.3(6), 617–627 (2004).
[PubMed]

Other

D. Kleinbaum, L. Kupper, K. Muller, and A. Nizam, Applied Regression Analysis and Other Multivariable Methods, 3rd ed. (Duxbury Press, 1998).

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Figures (3)

Fig. 1
Fig. 1

(a) TD/FD-PS-OCT systems configuration. QWP: quarter-wave plate; PD: photodetector. (b) Phase retardation image; white dashed rectangular: selected area for fitting; scale bar: 0.5mm; (c) averaged A-lines and numerical fitting curve.

Fig. 2
Fig. 2

(a) Scatter plot of phase retardation rate of normal and malignant ovary groups. (b) Positive correlation demonstration between phase retardation rate and collagen content; the blue dashed lines show 95% confidence interval.

Fig.
        3
Fig. 3

ROC and AUC of different prediction models. (a) Training and (b) testing results.

Tables (2)

Tables Icon

Table 1 Summary of Logistic Model Results by Using Different Parametersa

Tables Icon

Table 2 Summary of Testing Results

Equations (1)

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pr(Y=1| X 1 , X 2 ,..., X K )= 1 1+exp[ ( β 0 + n=1 k β n X n ) ]

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