Abstract

Guiding the growth of a neurite by directing ~800 nm laser light to the leading edge of the neurite's growing region can be accomplished by controlling the position and direction in three dimensional space of a tapered optical fiber through which the light is projected. We control the position, angle and power of the laser beam to direct the growth of actin accumulations in neurites which affects their mobility.

© 2013 OSA

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  1. D. Koch, T. Betz, A. Ehrlicher, M. Gogler, B. Stuhrmann, and J. Kas, “Optical control of neuronal growth,” Proc. SPIE 5514, 428–436 (2004).
    [Crossref]
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    [Crossref] [PubMed]
  3. A. Higuchi, H. Kitamura, K. Shishimine, S. Konishi, B. O. Yoon, and M. Hara, “Visible light is able to regulate neurite outgrowth,” J. Biomater. Sci. Polym. Ed. 14(12), 1377–1388 (2003).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  5. A. Higuchi, T. Watanabe, Y. Matsubara, Y. Matsuoka, and S. Hayashi, “Regulation of neurite outgrowth by intermittent irradiation of visible light,” J. Phys. Chem. B 109(21), 11033–11036 (2005).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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2009 (2)

C. E. Graves, R. G. McAllister, W. J. Rosoff, and J. S. Urbach, “Optical neuronal guidance in three-dimensional matrices,” J. Neurosci. Methods 179(2), 278–283 (2009).
[Crossref] [PubMed]

T. Betz, D. Koch, D. Lim, and J. A. Käs, “Stochastic actin polymerization and steady retrograde flow determine growth cone advancement,” Biophys. J. 96(12), 5130–5138 (2009).
[Crossref] [PubMed]

2007 (3)

A. Ehrlicher, T. Betz, B. Stuhrmann, M. Gögler, D. Koch, K. Franze, Y. Lu, and J. Käs, “Optical neuronal guidance,” Methods Cell Biol. 83, 495–520 (2007).
[Crossref] [PubMed]

A. Higuchi, T. Watanabe, Y. Noguchi, Y. Chang, W. Y. Chen, and Y. Matsuoka, “Visible light regulates neurite outgrowth of nerve cells,” Cytotechnology 54(3), 181–188 (2007).
[Crossref] [PubMed]

R. Kitamura, L. Pilon, and M. Jonasz, “Optical constants of silica glass from extreme ultraviolet to far infrared at near room temperature,” Appl. Opt. 46(33), 8118–8133 (2007).
[Crossref] [PubMed]

2005 (1)

A. Higuchi, T. Watanabe, Y. Matsubara, Y. Matsuoka, and S. Hayashi, “Regulation of neurite outgrowth by intermittent irradiation of visible light,” J. Phys. Chem. B 109(21), 11033–11036 (2005).
[Crossref] [PubMed]

2004 (1)

D. Koch, T. Betz, A. Ehrlicher, M. Gogler, B. Stuhrmann, and J. Kas, “Optical control of neuronal growth,” Proc. SPIE 5514, 428–436 (2004).
[Crossref]

2003 (1)

A. Higuchi, H. Kitamura, K. Shishimine, S. Konishi, B. O. Yoon, and M. Hara, “Visible light is able to regulate neurite outgrowth,” J. Biomater. Sci. Polym. Ed. 14(12), 1377–1388 (2003).
[Crossref] [PubMed]

2002 (1)

A. Ehrlicher, T. Betz, B. Stuhrmann, D. Koch, V. Milner, M. G. Raizen, and J. Kas, “Guiding neuronal growth with light,” Proc. Natl. Acad. Sci. U.S.A. 99(25), 16024–16028 (2002).
[Crossref] [PubMed]

2000 (1)

V. Vasioukhin, C. Bauer, M. Yin, and E. Fuchs, “Directed actin polymerization is the driving force for epithelial cell-cell adhesion,” Cell 100(2), 209–219 (2000).
[Crossref] [PubMed]

1996 (2)

P. E. Ciddor, “Refractive index of air: new equations for the visible and near infrared,” Appl. Opt. 35(9), 1566–1573 (1996).
[Crossref] [PubMed]

Y. Wollman, S. Rochkind, and R. Simantov, “Low power laser irradiation enhances migration and neurite sprouting of cultured rat embryonal brain cells,” Neurol. Res. 18(5), 467–470 (1996).
[PubMed]

1993 (1)

J. J. Anders, R. C. Borke, S. K. Woolery, and W. P. Van de Merwe, “Low power laser irradiation alters the rate of regeneration of the rat facial nerve,” Lasers Surg. Med. 13(1), 72–82 (1993).
[Crossref] [PubMed]

1990 (1)

P. Schiebener, J. Straub, J. M. H. Levelt Sengers, and J. S. Gallagher, “Refractive index of water and steam as function of wavelength, temperature and density,” J. Phys. Chem. Ref. Data 19(3), 677–715 (1990).
[Crossref]

Anders, J. J.

J. J. Anders, R. C. Borke, S. K. Woolery, and W. P. Van de Merwe, “Low power laser irradiation alters the rate of regeneration of the rat facial nerve,” Lasers Surg. Med. 13(1), 72–82 (1993).
[Crossref] [PubMed]

Bauer, C.

V. Vasioukhin, C. Bauer, M. Yin, and E. Fuchs, “Directed actin polymerization is the driving force for epithelial cell-cell adhesion,” Cell 100(2), 209–219 (2000).
[Crossref] [PubMed]

Betz, T.

T. Betz, D. Koch, D. Lim, and J. A. Käs, “Stochastic actin polymerization and steady retrograde flow determine growth cone advancement,” Biophys. J. 96(12), 5130–5138 (2009).
[Crossref] [PubMed]

A. Ehrlicher, T. Betz, B. Stuhrmann, M. Gögler, D. Koch, K. Franze, Y. Lu, and J. Käs, “Optical neuronal guidance,” Methods Cell Biol. 83, 495–520 (2007).
[Crossref] [PubMed]

D. Koch, T. Betz, A. Ehrlicher, M. Gogler, B. Stuhrmann, and J. Kas, “Optical control of neuronal growth,” Proc. SPIE 5514, 428–436 (2004).
[Crossref]

A. Ehrlicher, T. Betz, B. Stuhrmann, D. Koch, V. Milner, M. G. Raizen, and J. Kas, “Guiding neuronal growth with light,” Proc. Natl. Acad. Sci. U.S.A. 99(25), 16024–16028 (2002).
[Crossref] [PubMed]

Borke, R. C.

J. J. Anders, R. C. Borke, S. K. Woolery, and W. P. Van de Merwe, “Low power laser irradiation alters the rate of regeneration of the rat facial nerve,” Lasers Surg. Med. 13(1), 72–82 (1993).
[Crossref] [PubMed]

Chang, Y.

A. Higuchi, T. Watanabe, Y. Noguchi, Y. Chang, W. Y. Chen, and Y. Matsuoka, “Visible light regulates neurite outgrowth of nerve cells,” Cytotechnology 54(3), 181–188 (2007).
[Crossref] [PubMed]

Chen, W. Y.

A. Higuchi, T. Watanabe, Y. Noguchi, Y. Chang, W. Y. Chen, and Y. Matsuoka, “Visible light regulates neurite outgrowth of nerve cells,” Cytotechnology 54(3), 181–188 (2007).
[Crossref] [PubMed]

Ciddor, P. E.

Ehrlicher, A.

A. Ehrlicher, T. Betz, B. Stuhrmann, M. Gögler, D. Koch, K. Franze, Y. Lu, and J. Käs, “Optical neuronal guidance,” Methods Cell Biol. 83, 495–520 (2007).
[Crossref] [PubMed]

D. Koch, T. Betz, A. Ehrlicher, M. Gogler, B. Stuhrmann, and J. Kas, “Optical control of neuronal growth,” Proc. SPIE 5514, 428–436 (2004).
[Crossref]

A. Ehrlicher, T. Betz, B. Stuhrmann, D. Koch, V. Milner, M. G. Raizen, and J. Kas, “Guiding neuronal growth with light,” Proc. Natl. Acad. Sci. U.S.A. 99(25), 16024–16028 (2002).
[Crossref] [PubMed]

Franze, K.

A. Ehrlicher, T. Betz, B. Stuhrmann, M. Gögler, D. Koch, K. Franze, Y. Lu, and J. Käs, “Optical neuronal guidance,” Methods Cell Biol. 83, 495–520 (2007).
[Crossref] [PubMed]

Fuchs, E.

V. Vasioukhin, C. Bauer, M. Yin, and E. Fuchs, “Directed actin polymerization is the driving force for epithelial cell-cell adhesion,” Cell 100(2), 209–219 (2000).
[Crossref] [PubMed]

Gallagher, J. S.

P. Schiebener, J. Straub, J. M. H. Levelt Sengers, and J. S. Gallagher, “Refractive index of water and steam as function of wavelength, temperature and density,” J. Phys. Chem. Ref. Data 19(3), 677–715 (1990).
[Crossref]

Gogler, M.

D. Koch, T. Betz, A. Ehrlicher, M. Gogler, B. Stuhrmann, and J. Kas, “Optical control of neuronal growth,” Proc. SPIE 5514, 428–436 (2004).
[Crossref]

Gögler, M.

A. Ehrlicher, T. Betz, B. Stuhrmann, M. Gögler, D. Koch, K. Franze, Y. Lu, and J. Käs, “Optical neuronal guidance,” Methods Cell Biol. 83, 495–520 (2007).
[Crossref] [PubMed]

Graves, C. E.

C. E. Graves, R. G. McAllister, W. J. Rosoff, and J. S. Urbach, “Optical neuronal guidance in three-dimensional matrices,” J. Neurosci. Methods 179(2), 278–283 (2009).
[Crossref] [PubMed]

Hara, M.

A. Higuchi, H. Kitamura, K. Shishimine, S. Konishi, B. O. Yoon, and M. Hara, “Visible light is able to regulate neurite outgrowth,” J. Biomater. Sci. Polym. Ed. 14(12), 1377–1388 (2003).
[Crossref] [PubMed]

Hayashi, S.

A. Higuchi, T. Watanabe, Y. Matsubara, Y. Matsuoka, and S. Hayashi, “Regulation of neurite outgrowth by intermittent irradiation of visible light,” J. Phys. Chem. B 109(21), 11033–11036 (2005).
[Crossref] [PubMed]

Higuchi, A.

A. Higuchi, T. Watanabe, Y. Noguchi, Y. Chang, W. Y. Chen, and Y. Matsuoka, “Visible light regulates neurite outgrowth of nerve cells,” Cytotechnology 54(3), 181–188 (2007).
[Crossref] [PubMed]

A. Higuchi, T. Watanabe, Y. Matsubara, Y. Matsuoka, and S. Hayashi, “Regulation of neurite outgrowth by intermittent irradiation of visible light,” J. Phys. Chem. B 109(21), 11033–11036 (2005).
[Crossref] [PubMed]

A. Higuchi, H. Kitamura, K. Shishimine, S. Konishi, B. O. Yoon, and M. Hara, “Visible light is able to regulate neurite outgrowth,” J. Biomater. Sci. Polym. Ed. 14(12), 1377–1388 (2003).
[Crossref] [PubMed]

Jonasz, M.

Kas, J.

D. Koch, T. Betz, A. Ehrlicher, M. Gogler, B. Stuhrmann, and J. Kas, “Optical control of neuronal growth,” Proc. SPIE 5514, 428–436 (2004).
[Crossref]

A. Ehrlicher, T. Betz, B. Stuhrmann, D. Koch, V. Milner, M. G. Raizen, and J. Kas, “Guiding neuronal growth with light,” Proc. Natl. Acad. Sci. U.S.A. 99(25), 16024–16028 (2002).
[Crossref] [PubMed]

Käs, J.

A. Ehrlicher, T. Betz, B. Stuhrmann, M. Gögler, D. Koch, K. Franze, Y. Lu, and J. Käs, “Optical neuronal guidance,” Methods Cell Biol. 83, 495–520 (2007).
[Crossref] [PubMed]

Käs, J. A.

T. Betz, D. Koch, D. Lim, and J. A. Käs, “Stochastic actin polymerization and steady retrograde flow determine growth cone advancement,” Biophys. J. 96(12), 5130–5138 (2009).
[Crossref] [PubMed]

Kitamura, H.

A. Higuchi, H. Kitamura, K. Shishimine, S. Konishi, B. O. Yoon, and M. Hara, “Visible light is able to regulate neurite outgrowth,” J. Biomater. Sci. Polym. Ed. 14(12), 1377–1388 (2003).
[Crossref] [PubMed]

Kitamura, R.

Koch, D.

T. Betz, D. Koch, D. Lim, and J. A. Käs, “Stochastic actin polymerization and steady retrograde flow determine growth cone advancement,” Biophys. J. 96(12), 5130–5138 (2009).
[Crossref] [PubMed]

A. Ehrlicher, T. Betz, B. Stuhrmann, M. Gögler, D. Koch, K. Franze, Y. Lu, and J. Käs, “Optical neuronal guidance,” Methods Cell Biol. 83, 495–520 (2007).
[Crossref] [PubMed]

D. Koch, T. Betz, A. Ehrlicher, M. Gogler, B. Stuhrmann, and J. Kas, “Optical control of neuronal growth,” Proc. SPIE 5514, 428–436 (2004).
[Crossref]

A. Ehrlicher, T. Betz, B. Stuhrmann, D. Koch, V. Milner, M. G. Raizen, and J. Kas, “Guiding neuronal growth with light,” Proc. Natl. Acad. Sci. U.S.A. 99(25), 16024–16028 (2002).
[Crossref] [PubMed]

Konishi, S.

A. Higuchi, H. Kitamura, K. Shishimine, S. Konishi, B. O. Yoon, and M. Hara, “Visible light is able to regulate neurite outgrowth,” J. Biomater. Sci. Polym. Ed. 14(12), 1377–1388 (2003).
[Crossref] [PubMed]

Levelt Sengers, J. M. H.

P. Schiebener, J. Straub, J. M. H. Levelt Sengers, and J. S. Gallagher, “Refractive index of water and steam as function of wavelength, temperature and density,” J. Phys. Chem. Ref. Data 19(3), 677–715 (1990).
[Crossref]

Lim, D.

T. Betz, D. Koch, D. Lim, and J. A. Käs, “Stochastic actin polymerization and steady retrograde flow determine growth cone advancement,” Biophys. J. 96(12), 5130–5138 (2009).
[Crossref] [PubMed]

Lu, Y.

A. Ehrlicher, T. Betz, B. Stuhrmann, M. Gögler, D. Koch, K. Franze, Y. Lu, and J. Käs, “Optical neuronal guidance,” Methods Cell Biol. 83, 495–520 (2007).
[Crossref] [PubMed]

Matsubara, Y.

A. Higuchi, T. Watanabe, Y. Matsubara, Y. Matsuoka, and S. Hayashi, “Regulation of neurite outgrowth by intermittent irradiation of visible light,” J. Phys. Chem. B 109(21), 11033–11036 (2005).
[Crossref] [PubMed]

Matsuoka, Y.

A. Higuchi, T. Watanabe, Y. Noguchi, Y. Chang, W. Y. Chen, and Y. Matsuoka, “Visible light regulates neurite outgrowth of nerve cells,” Cytotechnology 54(3), 181–188 (2007).
[Crossref] [PubMed]

A. Higuchi, T. Watanabe, Y. Matsubara, Y. Matsuoka, and S. Hayashi, “Regulation of neurite outgrowth by intermittent irradiation of visible light,” J. Phys. Chem. B 109(21), 11033–11036 (2005).
[Crossref] [PubMed]

McAllister, R. G.

C. E. Graves, R. G. McAllister, W. J. Rosoff, and J. S. Urbach, “Optical neuronal guidance in three-dimensional matrices,” J. Neurosci. Methods 179(2), 278–283 (2009).
[Crossref] [PubMed]

Milner, V.

A. Ehrlicher, T. Betz, B. Stuhrmann, D. Koch, V. Milner, M. G. Raizen, and J. Kas, “Guiding neuronal growth with light,” Proc. Natl. Acad. Sci. U.S.A. 99(25), 16024–16028 (2002).
[Crossref] [PubMed]

Noguchi, Y.

A. Higuchi, T. Watanabe, Y. Noguchi, Y. Chang, W. Y. Chen, and Y. Matsuoka, “Visible light regulates neurite outgrowth of nerve cells,” Cytotechnology 54(3), 181–188 (2007).
[Crossref] [PubMed]

Pilon, L.

Raizen, M. G.

A. Ehrlicher, T. Betz, B. Stuhrmann, D. Koch, V. Milner, M. G. Raizen, and J. Kas, “Guiding neuronal growth with light,” Proc. Natl. Acad. Sci. U.S.A. 99(25), 16024–16028 (2002).
[Crossref] [PubMed]

Rochkind, S.

Y. Wollman, S. Rochkind, and R. Simantov, “Low power laser irradiation enhances migration and neurite sprouting of cultured rat embryonal brain cells,” Neurol. Res. 18(5), 467–470 (1996).
[PubMed]

Rosoff, W. J.

C. E. Graves, R. G. McAllister, W. J. Rosoff, and J. S. Urbach, “Optical neuronal guidance in three-dimensional matrices,” J. Neurosci. Methods 179(2), 278–283 (2009).
[Crossref] [PubMed]

Schiebener, P.

P. Schiebener, J. Straub, J. M. H. Levelt Sengers, and J. S. Gallagher, “Refractive index of water and steam as function of wavelength, temperature and density,” J. Phys. Chem. Ref. Data 19(3), 677–715 (1990).
[Crossref]

Shishimine, K.

A. Higuchi, H. Kitamura, K. Shishimine, S. Konishi, B. O. Yoon, and M. Hara, “Visible light is able to regulate neurite outgrowth,” J. Biomater. Sci. Polym. Ed. 14(12), 1377–1388 (2003).
[Crossref] [PubMed]

Simantov, R.

Y. Wollman, S. Rochkind, and R. Simantov, “Low power laser irradiation enhances migration and neurite sprouting of cultured rat embryonal brain cells,” Neurol. Res. 18(5), 467–470 (1996).
[PubMed]

Straub, J.

P. Schiebener, J. Straub, J. M. H. Levelt Sengers, and J. S. Gallagher, “Refractive index of water and steam as function of wavelength, temperature and density,” J. Phys. Chem. Ref. Data 19(3), 677–715 (1990).
[Crossref]

Stuhrmann, B.

A. Ehrlicher, T. Betz, B. Stuhrmann, M. Gögler, D. Koch, K. Franze, Y. Lu, and J. Käs, “Optical neuronal guidance,” Methods Cell Biol. 83, 495–520 (2007).
[Crossref] [PubMed]

D. Koch, T. Betz, A. Ehrlicher, M. Gogler, B. Stuhrmann, and J. Kas, “Optical control of neuronal growth,” Proc. SPIE 5514, 428–436 (2004).
[Crossref]

A. Ehrlicher, T. Betz, B. Stuhrmann, D. Koch, V. Milner, M. G. Raizen, and J. Kas, “Guiding neuronal growth with light,” Proc. Natl. Acad. Sci. U.S.A. 99(25), 16024–16028 (2002).
[Crossref] [PubMed]

Urbach, J. S.

C. E. Graves, R. G. McAllister, W. J. Rosoff, and J. S. Urbach, “Optical neuronal guidance in three-dimensional matrices,” J. Neurosci. Methods 179(2), 278–283 (2009).
[Crossref] [PubMed]

Van de Merwe, W. P.

J. J. Anders, R. C. Borke, S. K. Woolery, and W. P. Van de Merwe, “Low power laser irradiation alters the rate of regeneration of the rat facial nerve,” Lasers Surg. Med. 13(1), 72–82 (1993).
[Crossref] [PubMed]

Vasioukhin, V.

V. Vasioukhin, C. Bauer, M. Yin, and E. Fuchs, “Directed actin polymerization is the driving force for epithelial cell-cell adhesion,” Cell 100(2), 209–219 (2000).
[Crossref] [PubMed]

Wang, F.

Peking Union Medical Institute Cell-Bank F. Wang atPeking Union Medical Institute.

Watanabe, T.

A. Higuchi, T. Watanabe, Y. Noguchi, Y. Chang, W. Y. Chen, and Y. Matsuoka, “Visible light regulates neurite outgrowth of nerve cells,” Cytotechnology 54(3), 181–188 (2007).
[Crossref] [PubMed]

A. Higuchi, T. Watanabe, Y. Matsubara, Y. Matsuoka, and S. Hayashi, “Regulation of neurite outgrowth by intermittent irradiation of visible light,” J. Phys. Chem. B 109(21), 11033–11036 (2005).
[Crossref] [PubMed]

Wollman, Y.

Y. Wollman, S. Rochkind, and R. Simantov, “Low power laser irradiation enhances migration and neurite sprouting of cultured rat embryonal brain cells,” Neurol. Res. 18(5), 467–470 (1996).
[PubMed]

Woolery, S. K.

J. J. Anders, R. C. Borke, S. K. Woolery, and W. P. Van de Merwe, “Low power laser irradiation alters the rate of regeneration of the rat facial nerve,” Lasers Surg. Med. 13(1), 72–82 (1993).
[Crossref] [PubMed]

Yin, M.

V. Vasioukhin, C. Bauer, M. Yin, and E. Fuchs, “Directed actin polymerization is the driving force for epithelial cell-cell adhesion,” Cell 100(2), 209–219 (2000).
[Crossref] [PubMed]

Yoon, B. O.

A. Higuchi, H. Kitamura, K. Shishimine, S. Konishi, B. O. Yoon, and M. Hara, “Visible light is able to regulate neurite outgrowth,” J. Biomater. Sci. Polym. Ed. 14(12), 1377–1388 (2003).
[Crossref] [PubMed]

Appl. Opt. (2)

Biophys. J. (1)

T. Betz, D. Koch, D. Lim, and J. A. Käs, “Stochastic actin polymerization and steady retrograde flow determine growth cone advancement,” Biophys. J. 96(12), 5130–5138 (2009).
[Crossref] [PubMed]

Cell (1)

V. Vasioukhin, C. Bauer, M. Yin, and E. Fuchs, “Directed actin polymerization is the driving force for epithelial cell-cell adhesion,” Cell 100(2), 209–219 (2000).
[Crossref] [PubMed]

Cytotechnology (1)

A. Higuchi, T. Watanabe, Y. Noguchi, Y. Chang, W. Y. Chen, and Y. Matsuoka, “Visible light regulates neurite outgrowth of nerve cells,” Cytotechnology 54(3), 181–188 (2007).
[Crossref] [PubMed]

J. Biomater. Sci. Polym. Ed. (1)

A. Higuchi, H. Kitamura, K. Shishimine, S. Konishi, B. O. Yoon, and M. Hara, “Visible light is able to regulate neurite outgrowth,” J. Biomater. Sci. Polym. Ed. 14(12), 1377–1388 (2003).
[Crossref] [PubMed]

J. Neurosci. Methods (1)

C. E. Graves, R. G. McAllister, W. J. Rosoff, and J. S. Urbach, “Optical neuronal guidance in three-dimensional matrices,” J. Neurosci. Methods 179(2), 278–283 (2009).
[Crossref] [PubMed]

J. Phys. Chem. B (1)

A. Higuchi, T. Watanabe, Y. Matsubara, Y. Matsuoka, and S. Hayashi, “Regulation of neurite outgrowth by intermittent irradiation of visible light,” J. Phys. Chem. B 109(21), 11033–11036 (2005).
[Crossref] [PubMed]

J. Phys. Chem. Ref. Data (1)

P. Schiebener, J. Straub, J. M. H. Levelt Sengers, and J. S. Gallagher, “Refractive index of water and steam as function of wavelength, temperature and density,” J. Phys. Chem. Ref. Data 19(3), 677–715 (1990).
[Crossref]

Lasers Surg. Med. (1)

J. J. Anders, R. C. Borke, S. K. Woolery, and W. P. Van de Merwe, “Low power laser irradiation alters the rate of regeneration of the rat facial nerve,” Lasers Surg. Med. 13(1), 72–82 (1993).
[Crossref] [PubMed]

Methods Cell Biol. (1)

A. Ehrlicher, T. Betz, B. Stuhrmann, M. Gögler, D. Koch, K. Franze, Y. Lu, and J. Käs, “Optical neuronal guidance,” Methods Cell Biol. 83, 495–520 (2007).
[Crossref] [PubMed]

Neurol. Res. (1)

Y. Wollman, S. Rochkind, and R. Simantov, “Low power laser irradiation enhances migration and neurite sprouting of cultured rat embryonal brain cells,” Neurol. Res. 18(5), 467–470 (1996).
[PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

A. Ehrlicher, T. Betz, B. Stuhrmann, D. Koch, V. Milner, M. G. Raizen, and J. Kas, “Guiding neuronal growth with light,” Proc. Natl. Acad. Sci. U.S.A. 99(25), 16024–16028 (2002).
[Crossref] [PubMed]

Proc. SPIE (1)

D. Koch, T. Betz, A. Ehrlicher, M. Gogler, B. Stuhrmann, and J. Kas, “Optical control of neuronal growth,” Proc. SPIE 5514, 428–436 (2004).
[Crossref]

Other (4)

Chinese Academy of Medical Sciences, Institute for Experimental Animal Research.

Peking Union Medical Institute Cell-Bank F. Wang atPeking Union Medical Institute.

F. Jesse, Z. J. Miao, L. Zhao, Y. Chen, and Y. Y. Lv, “OSA2012-11 image sequences and data,” http://jesse.org/OSA2012-11/

Corning Incorporated, “Corning® ClearCurve® Multimode Optical Fiber Product information,” http://www.corning.com/assets/0/433/573/583/9F39014A-1475-4F63-A9A5-946B2DD39D69.pdf

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Figures (4)

Fig. 1
Fig. 1

PC12 neurite making an almost 90 degree turn, image cropped.

Fig. 2
Fig. 2

Rat neurite making a 180 degree turn, image contrast increased, cropped.

Fig. 3
Fig. 3

Tracking the surface area size of dark agglomerations of polymerized actin (tracked as pixel blobs) in the growth cone: their size is correlated with illumination from the fiber taper, compared with areas of polymerized actin in control neurites, median values.

Fig. 4
Fig. 4

Through-the-microscope view (looking down), the diagram shows the energy of the illumination at points v1, v2, and v3. v1: r = 1 μm, 45 mW /μm2; v3: r = 3 μm, 4.8 mW/μm2; v5: r = 5 μm, 1.72 mW /μm2.

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