Abstract

We show how to apply the Mellin-Laplace transform to process time-resolved reflectance measurements for diffuse optical tomography. We illustrate this method on simulated signals incorporating the main sources of experimental noise and suggest how to fine-tune the method in order to detect the deepest absorbing inclusions and optimize their localization in depth, depending on the dynamic range of the measurement. To finish, we apply this method to measurements acquired with a setup including a femtosecond laser, photomultipliers and a time-correlated single photon counting board. Simulations and experiments are illustrated for a probe featuring the interfiber distance of 1.5 cm and show the potential of time-resolved techniques for imaging absorption contrast in depth with this geometry.

© 2013 OSA

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  1. B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys.35(6), 2443–2451 (2008).
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  8. S. Del Bianco, F. Martelli, and G. Zaccanti, “Penetration depth of light re-emitted by a diffusive medium: theoretical and experimental investigation,” Phys. Med. Biol.47(23), 4131–4144 (2002).
    [CrossRef] [PubMed]
  9. N. Ducros, L. Hervé, A. Da Silva, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part I. Theoretical material,” Phys. Med. Biol.54(23), 7089–7105 (2009).
    [CrossRef] [PubMed]
  10. N. Ducros, A. Da Silva, L. Hervé, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part II. Three-dimensional reconstructions,” Phys. Med. Biol.54(23), 7107–7119 (2009).
    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef]

2012 (1)

2010 (3)

J. Liu, A. Li, A. E. Cerussi, and B. J. Tromberg, “Parametric diffuse optical imaging in reflectance geometry,” IEEE J. Quantum Electron.16(3), 555–564 (2010).
[CrossRef] [PubMed]

M. Kacprzak, A. Liebert, P. Sawosz, N. Zolek, D. Milej, and R. Maniewski, “Time-resolved imaging of fluorescent inclusions in optically turbid medium – phantom study,” Opto-Electron. Rev.18(1), 37–47 (2010).
[CrossRef]

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron.16(4), 1023–1030 (2010).
[CrossRef]

2009 (3)

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J.-M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt.14(6), 064001 (2009).
[CrossRef] [PubMed]

N. Ducros, L. Hervé, A. Da Silva, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part I. Theoretical material,” Phys. Med. Biol.54(23), 7089–7105 (2009).
[CrossRef] [PubMed]

N. Ducros, A. Da Silva, L. Hervé, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part II. Three-dimensional reconstructions,” Phys. Med. Biol.54(23), 7107–7119 (2009).
[CrossRef] [PubMed]

2008 (1)

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys.35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

2007 (3)

J. Riley, M. Hassan, V. Chernomordik, and A. Gandjbakhche, “Choice of data types in time resolved fluorescence enhanced diffuse optical tomography,” Med. Phys.34(12), 4890–4900 (2007).
[CrossRef] [PubMed]

H. Zhao, F. Gao, Y. Tanikawa, and Y. Yamada, “Time-resolved diffuse optical tomography and its application to in vitro and in vivo imaging,” J. Biomed. Opt.12(6), 062107 (2007).
[CrossRef] [PubMed]

J. Selb, A. M. Dale, and D. A. Boas, “Linear 3D reconstruction of time-domain diffuse optical imaging differential data: improved depth localization and lateral resolution,” Opt. Express15(25), 16400–16412 (2007).
[CrossRef] [PubMed]

2006 (2)

B. Montcel, R. Chabrier, and P. Poulet, “Time-resolved absorption and hemoglobin concentration difference maps: a method to retrieve depth-related information on cerebral hemodynamics,” Opt. Express14(25), 12271–12287 (2006).
[CrossRef] [PubMed]

T. Austin, A. P. Gibson, G. Branco, R. M. Yusof, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain,” Neuroimage31(4), 1426–1433 (2006).
[CrossRef] [PubMed]

2003 (2)

J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. M. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti, and F. Martelli, “Assessment of an in situ temporal calibration method for time-resolved optical tomography,” J. Biomed. Opt.8(1), 87–92 (2003).
[CrossRef] [PubMed]

R. M. Yusof, J. C. Hebden, A. Gibson, N. Everdell, T. Austin, J. H. Meek, S. R. Arridge, J. S. Wyatt, and D. T. Delpy, “Validation of the use of homogenous reference phantoms for optical tomography of the neonatal brain,” Proc. SPIE4955, 6–11 (2003).

2002 (4)

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, “Bulk optical properties of healthy female breast tissue,” Phys. Med. Biol.47(16), 2847–2861 (2002).
[CrossRef] [PubMed]

F. Gao, H. Zhao, and Y. Yamada, “Improvement of image quality in diffuse optical tomography by use of full time-resolved data,” Appl. Opt.41(4), 778–791 (2002).
[CrossRef] [PubMed]

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol.47(23), 4155–4166 (2002).
[CrossRef] [PubMed]

S. Del Bianco, F. Martelli, and G. Zaccanti, “Penetration depth of light re-emitted by a diffusive medium: theoretical and experimental investigation,” Phys. Med. Biol.47(23), 4131–4144 (2002).
[CrossRef] [PubMed]

2000 (1)

E. M. C. Hillman, J. C. Hebden, F. E. W. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum.71(9), 3415–3427 (2000).
[CrossRef]

1999 (1)

M. Schweiger and S. R. Arridge, “Application of temporal filters to time resolved data in optical tomography,” Phys. Med. Biol.44(7), 1699–1717 (1999).
[CrossRef] [PubMed]

1998 (1)

A. H. Hielscher, R. E. Alcouffe, and R. L. Barbour, “Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues,” Phys. Med. Biol.43(5), 1285–1302 (1998).
[CrossRef] [PubMed]

1995 (1)

Alcouffe, R. E.

A. H. Hielscher, R. E. Alcouffe, and R. L. Barbour, “Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues,” Phys. Med. Biol.43(5), 1285–1302 (1998).
[CrossRef] [PubMed]

Arridge, S. R.

T. Austin, A. P. Gibson, G. Branco, R. M. Yusof, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain,” Neuroimage31(4), 1426–1433 (2006).
[CrossRef] [PubMed]

R. M. Yusof, J. C. Hebden, A. Gibson, N. Everdell, T. Austin, J. H. Meek, S. R. Arridge, J. S. Wyatt, and D. T. Delpy, “Validation of the use of homogenous reference phantoms for optical tomography of the neonatal brain,” Proc. SPIE4955, 6–11 (2003).

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol.47(23), 4155–4166 (2002).
[CrossRef] [PubMed]

E. M. C. Hillman, J. C. Hebden, F. E. W. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum.71(9), 3415–3427 (2000).
[CrossRef]

M. Schweiger and S. R. Arridge, “Application of temporal filters to time resolved data in optical tomography,” Phys. Med. Biol.44(7), 1699–1717 (1999).
[CrossRef] [PubMed]

S. R. Arridge, “Photon-measurement density functions. Part I: Analytical forms,” Appl. Opt.34(31), 7395–7409 (1995).
[CrossRef] [PubMed]

Austin, T.

T. Austin, A. P. Gibson, G. Branco, R. M. Yusof, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain,” Neuroimage31(4), 1426–1433 (2006).
[CrossRef] [PubMed]

R. M. Yusof, J. C. Hebden, A. Gibson, N. Everdell, T. Austin, J. H. Meek, S. R. Arridge, J. S. Wyatt, and D. T. Delpy, “Validation of the use of homogenous reference phantoms for optical tomography of the neonatal brain,” Proc. SPIE4955, 6–11 (2003).

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol.47(23), 4155–4166 (2002).
[CrossRef] [PubMed]

Barbour, R. L.

A. H. Hielscher, R. E. Alcouffe, and R. L. Barbour, “Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues,” Phys. Med. Biol.43(5), 1285–1302 (1998).
[CrossRef] [PubMed]

Boas, D. A.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys.35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

J. Selb, A. M. Dale, and D. A. Boas, “Linear 3D reconstruction of time-domain diffuse optical imaging differential data: improved depth localization and lateral resolution,” Opt. Express15(25), 16400–16412 (2007).
[CrossRef] [PubMed]

Boutet, J.

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J.-M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt.14(6), 064001 (2009).
[CrossRef] [PubMed]

Branco, G.

T. Austin, A. P. Gibson, G. Branco, R. M. Yusof, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain,” Neuroimage31(4), 1426–1433 (2006).
[CrossRef] [PubMed]

Cerussi, A. E.

J. Liu, A. Li, A. E. Cerussi, and B. J. Tromberg, “Parametric diffuse optical imaging in reflectance geometry,” IEEE J. Quantum Electron.16(3), 555–564 (2010).
[CrossRef] [PubMed]

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys.35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

Chabrier, R.

Chance, B.

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, “Bulk optical properties of healthy female breast tissue,” Phys. Med. Biol.47(16), 2847–2861 (2002).
[CrossRef] [PubMed]

Chernomordik, V.

J. Riley, M. Hassan, V. Chernomordik, and A. Gandjbakhche, “Choice of data types in time resolved fluorescence enhanced diffuse optical tomography,” Med. Phys.34(12), 4890–4900 (2007).
[CrossRef] [PubMed]

Choe, R.

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, “Bulk optical properties of healthy female breast tissue,” Phys. Med. Biol.47(16), 2847–2861 (2002).
[CrossRef] [PubMed]

Contini, D.

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron.16(4), 1023–1030 (2010).
[CrossRef]

Cova, S.

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron.16(4), 1023–1030 (2010).
[CrossRef]

Cubeddu, R.

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron.16(4), 1023–1030 (2010).
[CrossRef]

Culver, J. P.

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, “Bulk optical properties of healthy female breast tissue,” Phys. Med. Biol.47(16), 2847–2861 (2002).
[CrossRef] [PubMed]

Da Silva, A.

N. Ducros, A. Da Silva, L. Hervé, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part II. Three-dimensional reconstructions,” Phys. Med. Biol.54(23), 7107–7119 (2009).
[CrossRef] [PubMed]

N. Ducros, L. Hervé, A. Da Silva, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part I. Theoretical material,” Phys. Med. Biol.54(23), 7089–7105 (2009).
[CrossRef] [PubMed]

Dale, A. M.

Dalla Mora, A.

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron.16(4), 1023–1030 (2010).
[CrossRef]

Debourdeau, M.

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J.-M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt.14(6), 064001 (2009).
[CrossRef] [PubMed]

Dehghani, H.

E. M. C. Hillman, J. C. Hebden, F. E. W. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum.71(9), 3415–3427 (2000).
[CrossRef]

Del Bianco, S.

S. Del Bianco, F. Martelli, and G. Zaccanti, “Penetration depth of light re-emitted by a diffusive medium: theoretical and experimental investigation,” Phys. Med. Biol.47(23), 4131–4144 (2002).
[CrossRef] [PubMed]

Delpy, D. T.

T. Austin, A. P. Gibson, G. Branco, R. M. Yusof, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain,” Neuroimage31(4), 1426–1433 (2006).
[CrossRef] [PubMed]

J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. M. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti, and F. Martelli, “Assessment of an in situ temporal calibration method for time-resolved optical tomography,” J. Biomed. Opt.8(1), 87–92 (2003).
[CrossRef] [PubMed]

R. M. Yusof, J. C. Hebden, A. Gibson, N. Everdell, T. Austin, J. H. Meek, S. R. Arridge, J. S. Wyatt, and D. T. Delpy, “Validation of the use of homogenous reference phantoms for optical tomography of the neonatal brain,” Proc. SPIE4955, 6–11 (2003).

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol.47(23), 4155–4166 (2002).
[CrossRef] [PubMed]

E. M. C. Hillman, J. C. Hebden, F. E. W. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum.71(9), 3415–3427 (2000).
[CrossRef]

Dinten, J.-M.

L. Hervé, A. Puszka, A. Planat-Chrétien, and J.-M. Dinten, “Time-domain diffuse optical tomography processing by using the Mellin-Laplace transform,” Appl. Opt.51(25), 5978–5988 (2012).
[CrossRef] [PubMed]

N. Ducros, A. Da Silva, L. Hervé, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part II. Three-dimensional reconstructions,” Phys. Med. Biol.54(23), 7107–7119 (2009).
[CrossRef] [PubMed]

N. Ducros, L. Hervé, A. Da Silva, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part I. Theoretical material,” Phys. Med. Biol.54(23), 7089–7105 (2009).
[CrossRef] [PubMed]

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J.-M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt.14(6), 064001 (2009).
[CrossRef] [PubMed]

Duboeuf, F.

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J.-M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt.14(6), 064001 (2009).
[CrossRef] [PubMed]

Ducros, N.

N. Ducros, L. Hervé, A. Da Silva, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part I. Theoretical material,” Phys. Med. Biol.54(23), 7089–7105 (2009).
[CrossRef] [PubMed]

N. Ducros, A. Da Silva, L. Hervé, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part II. Three-dimensional reconstructions,” Phys. Med. Biol.54(23), 7107–7119 (2009).
[CrossRef] [PubMed]

Durduran, T.

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, “Bulk optical properties of healthy female breast tissue,” Phys. Med. Biol.47(16), 2847–2861 (2002).
[CrossRef] [PubMed]

Everdell, N.

J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. M. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti, and F. Martelli, “Assessment of an in situ temporal calibration method for time-resolved optical tomography,” J. Biomed. Opt.8(1), 87–92 (2003).
[CrossRef] [PubMed]

R. M. Yusof, J. C. Hebden, A. Gibson, N. Everdell, T. Austin, J. H. Meek, S. R. Arridge, J. S. Wyatt, and D. T. Delpy, “Validation of the use of homogenous reference phantoms for optical tomography of the neonatal brain,” Proc. SPIE4955, 6–11 (2003).

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol.47(23), 4155–4166 (2002).
[CrossRef] [PubMed]

Gandjbakhche, A.

J. Riley, M. Hassan, V. Chernomordik, and A. Gandjbakhche, “Choice of data types in time resolved fluorescence enhanced diffuse optical tomography,” Med. Phys.34(12), 4890–4900 (2007).
[CrossRef] [PubMed]

Gao, F.

H. Zhao, F. Gao, Y. Tanikawa, and Y. Yamada, “Time-resolved diffuse optical tomography and its application to in vitro and in vivo imaging,” J. Biomed. Opt.12(6), 062107 (2007).
[CrossRef] [PubMed]

F. Gao, H. Zhao, and Y. Yamada, “Improvement of image quality in diffuse optical tomography by use of full time-resolved data,” Appl. Opt.41(4), 778–791 (2002).
[CrossRef] [PubMed]

Giammarco, J.

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, “Bulk optical properties of healthy female breast tissue,” Phys. Med. Biol.47(16), 2847–2861 (2002).
[CrossRef] [PubMed]

Gibson, A.

J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. M. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti, and F. Martelli, “Assessment of an in situ temporal calibration method for time-resolved optical tomography,” J. Biomed. Opt.8(1), 87–92 (2003).
[CrossRef] [PubMed]

R. M. Yusof, J. C. Hebden, A. Gibson, N. Everdell, T. Austin, J. H. Meek, S. R. Arridge, J. S. Wyatt, and D. T. Delpy, “Validation of the use of homogenous reference phantoms for optical tomography of the neonatal brain,” Proc. SPIE4955, 6–11 (2003).

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol.47(23), 4155–4166 (2002).
[CrossRef] [PubMed]

Gibson, A. P.

T. Austin, A. P. Gibson, G. Branco, R. M. Yusof, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain,” Neuroimage31(4), 1426–1433 (2006).
[CrossRef] [PubMed]

Gonzalez, F. M.

J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. M. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti, and F. Martelli, “Assessment of an in situ temporal calibration method for time-resolved optical tomography,” J. Biomed. Opt.8(1), 87–92 (2003).
[CrossRef] [PubMed]

Guyon, L.

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J.-M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt.14(6), 064001 (2009).
[CrossRef] [PubMed]

Hassan, M.

J. Riley, M. Hassan, V. Chernomordik, and A. Gandjbakhche, “Choice of data types in time resolved fluorescence enhanced diffuse optical tomography,” Med. Phys.34(12), 4890–4900 (2007).
[CrossRef] [PubMed]

Hebden, J. C.

T. Austin, A. P. Gibson, G. Branco, R. M. Yusof, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain,” Neuroimage31(4), 1426–1433 (2006).
[CrossRef] [PubMed]

J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. M. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti, and F. Martelli, “Assessment of an in situ temporal calibration method for time-resolved optical tomography,” J. Biomed. Opt.8(1), 87–92 (2003).
[CrossRef] [PubMed]

R. M. Yusof, J. C. Hebden, A. Gibson, N. Everdell, T. Austin, J. H. Meek, S. R. Arridge, J. S. Wyatt, and D. T. Delpy, “Validation of the use of homogenous reference phantoms for optical tomography of the neonatal brain,” Proc. SPIE4955, 6–11 (2003).

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol.47(23), 4155–4166 (2002).
[CrossRef] [PubMed]

E. M. C. Hillman, J. C. Hebden, F. E. W. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum.71(9), 3415–3427 (2000).
[CrossRef]

Herve, L.

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J.-M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt.14(6), 064001 (2009).
[CrossRef] [PubMed]

Hervé, L.

L. Hervé, A. Puszka, A. Planat-Chrétien, and J.-M. Dinten, “Time-domain diffuse optical tomography processing by using the Mellin-Laplace transform,” Appl. Opt.51(25), 5978–5988 (2012).
[CrossRef] [PubMed]

N. Ducros, A. Da Silva, L. Hervé, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part II. Three-dimensional reconstructions,” Phys. Med. Biol.54(23), 7107–7119 (2009).
[CrossRef] [PubMed]

N. Ducros, L. Hervé, A. Da Silva, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part I. Theoretical material,” Phys. Med. Biol.54(23), 7089–7105 (2009).
[CrossRef] [PubMed]

Hielscher, A. H.

A. H. Hielscher, R. E. Alcouffe, and R. L. Barbour, “Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues,” Phys. Med. Biol.43(5), 1285–1302 (1998).
[CrossRef] [PubMed]

Hillman, E. M. C.

J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. M. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti, and F. Martelli, “Assessment of an in situ temporal calibration method for time-resolved optical tomography,” J. Biomed. Opt.8(1), 87–92 (2003).
[CrossRef] [PubMed]

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol.47(23), 4155–4166 (2002).
[CrossRef] [PubMed]

E. M. C. Hillman, J. C. Hebden, F. E. W. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum.71(9), 3415–3427 (2000).
[CrossRef]

Holboke, M. J.

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, “Bulk optical properties of healthy female breast tissue,” Phys. Med. Biol.47(16), 2847–2861 (2002).
[CrossRef] [PubMed]

Kacprzak, M.

M. Kacprzak, A. Liebert, P. Sawosz, N. Zolek, D. Milej, and R. Maniewski, “Time-resolved imaging of fluorescent inclusions in optically turbid medium – phantom study,” Opto-Electron. Rev.18(1), 37–47 (2010).
[CrossRef]

Li, A.

J. Liu, A. Li, A. E. Cerussi, and B. J. Tromberg, “Parametric diffuse optical imaging in reflectance geometry,” IEEE J. Quantum Electron.16(3), 555–564 (2010).
[CrossRef] [PubMed]

Liebert, A.

M. Kacprzak, A. Liebert, P. Sawosz, N. Zolek, D. Milej, and R. Maniewski, “Time-resolved imaging of fluorescent inclusions in optically turbid medium – phantom study,” Opto-Electron. Rev.18(1), 37–47 (2010).
[CrossRef]

Liu, J.

J. Liu, A. Li, A. E. Cerussi, and B. J. Tromberg, “Parametric diffuse optical imaging in reflectance geometry,” IEEE J. Quantum Electron.16(3), 555–564 (2010).
[CrossRef] [PubMed]

Maniewski, R.

M. Kacprzak, A. Liebert, P. Sawosz, N. Zolek, D. Milej, and R. Maniewski, “Time-resolved imaging of fluorescent inclusions in optically turbid medium – phantom study,” Opto-Electron. Rev.18(1), 37–47 (2010).
[CrossRef]

Martelli, F.

J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. M. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti, and F. Martelli, “Assessment of an in situ temporal calibration method for time-resolved optical tomography,” J. Biomed. Opt.8(1), 87–92 (2003).
[CrossRef] [PubMed]

S. Del Bianco, F. Martelli, and G. Zaccanti, “Penetration depth of light re-emitted by a diffusive medium: theoretical and experimental investigation,” Phys. Med. Biol.47(23), 4131–4144 (2002).
[CrossRef] [PubMed]

Meek, J. H.

T. Austin, A. P. Gibson, G. Branco, R. M. Yusof, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain,” Neuroimage31(4), 1426–1433 (2006).
[CrossRef] [PubMed]

R. M. Yusof, J. C. Hebden, A. Gibson, N. Everdell, T. Austin, J. H. Meek, S. R. Arridge, J. S. Wyatt, and D. T. Delpy, “Validation of the use of homogenous reference phantoms for optical tomography of the neonatal brain,” Proc. SPIE4955, 6–11 (2003).

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol.47(23), 4155–4166 (2002).
[CrossRef] [PubMed]

Milej, D.

M. Kacprzak, A. Liebert, P. Sawosz, N. Zolek, D. Milej, and R. Maniewski, “Time-resolved imaging of fluorescent inclusions in optically turbid medium – phantom study,” Opto-Electron. Rev.18(1), 37–47 (2010).
[CrossRef]

Montcel, B.

Paulsen, K. D.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys.35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

Peltie, P.

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J.-M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt.14(6), 064001 (2009).
[CrossRef] [PubMed]

Peyrin, F.

N. Ducros, L. Hervé, A. Da Silva, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part I. Theoretical material,” Phys. Med. Biol.54(23), 7089–7105 (2009).
[CrossRef] [PubMed]

N. Ducros, A. Da Silva, L. Hervé, J.-M. Dinten, and F. Peyrin, “A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part II. Three-dimensional reconstructions,” Phys. Med. Biol.54(23), 7107–7119 (2009).
[CrossRef] [PubMed]

Pifferi, A.

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron.16(4), 1023–1030 (2010).
[CrossRef]

Planat-Chrétien, A.

Pogue, B. W.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys.35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

Poulet, P.

Puszka, A.

Riley, J.

J. Riley, M. Hassan, V. Chernomordik, and A. Gandjbakhche, “Choice of data types in time resolved fluorescence enhanced diffuse optical tomography,” Med. Phys.34(12), 4890–4900 (2007).
[CrossRef] [PubMed]

Saroul, L.

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J.-M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt.14(6), 064001 (2009).
[CrossRef] [PubMed]

Sawosz, P.

M. Kacprzak, A. Liebert, P. Sawosz, N. Zolek, D. Milej, and R. Maniewski, “Time-resolved imaging of fluorescent inclusions in optically turbid medium – phantom study,” Opto-Electron. Rev.18(1), 37–47 (2010).
[CrossRef]

Schmidt, F. E. W.

E. M. C. Hillman, J. C. Hebden, F. E. W. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum.71(9), 3415–3427 (2000).
[CrossRef]

Schweiger, M.

E. M. C. Hillman, J. C. Hebden, F. E. W. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum.71(9), 3415–3427 (2000).
[CrossRef]

M. Schweiger and S. R. Arridge, “Application of temporal filters to time resolved data in optical tomography,” Phys. Med. Biol.44(7), 1699–1717 (1999).
[CrossRef] [PubMed]

Selb, J.

Spinelli, L.

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron.16(4), 1023–1030 (2010).
[CrossRef]

Tanikawa, Y.

H. Zhao, F. Gao, Y. Tanikawa, and Y. Yamada, “Time-resolved diffuse optical tomography and its application to in vitro and in vivo imaging,” J. Biomed. Opt.12(6), 062107 (2007).
[CrossRef] [PubMed]

Torricelli, A.

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron.16(4), 1023–1030 (2010).
[CrossRef]

Tosi, A.

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron.16(4), 1023–1030 (2010).
[CrossRef]

Tromberg, B. J.

J. Liu, A. Li, A. E. Cerussi, and B. J. Tromberg, “Parametric diffuse optical imaging in reflectance geometry,” IEEE J. Quantum Electron.16(3), 555–564 (2010).
[CrossRef] [PubMed]

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys.35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

Vray, D.

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J.-M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt.14(6), 064001 (2009).
[CrossRef] [PubMed]

Wyatt, J. S.

T. Austin, A. P. Gibson, G. Branco, R. M. Yusof, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain,” Neuroimage31(4), 1426–1433 (2006).
[CrossRef] [PubMed]

R. M. Yusof, J. C. Hebden, A. Gibson, N. Everdell, T. Austin, J. H. Meek, S. R. Arridge, J. S. Wyatt, and D. T. Delpy, “Validation of the use of homogenous reference phantoms for optical tomography of the neonatal brain,” Proc. SPIE4955, 6–11 (2003).

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol.47(23), 4155–4166 (2002).
[CrossRef] [PubMed]

Yamada, Y.

H. Zhao, F. Gao, Y. Tanikawa, and Y. Yamada, “Time-resolved diffuse optical tomography and its application to in vitro and in vivo imaging,” J. Biomed. Opt.12(6), 062107 (2007).
[CrossRef] [PubMed]

F. Gao, H. Zhao, and Y. Yamada, “Improvement of image quality in diffuse optical tomography by use of full time-resolved data,” Appl. Opt.41(4), 778–791 (2002).
[CrossRef] [PubMed]

Yodh, A. G.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys.35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, “Bulk optical properties of healthy female breast tissue,” Phys. Med. Biol.47(16), 2847–2861 (2002).
[CrossRef] [PubMed]

Yusof, R. M.

T. Austin, A. P. Gibson, G. Branco, R. M. Yusof, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain,” Neuroimage31(4), 1426–1433 (2006).
[CrossRef] [PubMed]

J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. M. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti, and F. Martelli, “Assessment of an in situ temporal calibration method for time-resolved optical tomography,” J. Biomed. Opt.8(1), 87–92 (2003).
[CrossRef] [PubMed]

R. M. Yusof, J. C. Hebden, A. Gibson, N. Everdell, T. Austin, J. H. Meek, S. R. Arridge, J. S. Wyatt, and D. T. Delpy, “Validation of the use of homogenous reference phantoms for optical tomography of the neonatal brain,” Proc. SPIE4955, 6–11 (2003).

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol.47(23), 4155–4166 (2002).
[CrossRef] [PubMed]

Zaccanti, G.

J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. M. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti, and F. Martelli, “Assessment of an in situ temporal calibration method for time-resolved optical tomography,” J. Biomed. Opt.8(1), 87–92 (2003).
[CrossRef] [PubMed]

S. Del Bianco, F. Martelli, and G. Zaccanti, “Penetration depth of light re-emitted by a diffusive medium: theoretical and experimental investigation,” Phys. Med. Biol.47(23), 4131–4144 (2002).
[CrossRef] [PubMed]

Zappa, F.

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron.16(4), 1023–1030 (2010).
[CrossRef]

Zhao, H.

H. Zhao, F. Gao, Y. Tanikawa, and Y. Yamada, “Time-resolved diffuse optical tomography and its application to in vitro and in vivo imaging,” J. Biomed. Opt.12(6), 062107 (2007).
[CrossRef] [PubMed]

F. Gao, H. Zhao, and Y. Yamada, “Improvement of image quality in diffuse optical tomography by use of full time-resolved data,” Appl. Opt.41(4), 778–791 (2002).
[CrossRef] [PubMed]

Zolek, N.

M. Kacprzak, A. Liebert, P. Sawosz, N. Zolek, D. Milej, and R. Maniewski, “Time-resolved imaging of fluorescent inclusions in optically turbid medium – phantom study,” Opto-Electron. Rev.18(1), 37–47 (2010).
[CrossRef]

Zubkov, L.

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, “Bulk optical properties of healthy female breast tissue,” Phys. Med. Biol.47(16), 2847–2861 (2002).
[CrossRef] [PubMed]

Appl. Opt. (3)

IEEE J. Quantum Electron. (1)

J. Liu, A. Li, A. E. Cerussi, and B. J. Tromberg, “Parametric diffuse optical imaging in reflectance geometry,” IEEE J. Quantum Electron.16(3), 555–564 (2010).
[CrossRef] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (1)

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron.16(4), 1023–1030 (2010).
[CrossRef]

J. Biomed. Opt. (3)

J. Boutet, L. Herve, M. Debourdeau, L. Guyon, P. Peltie, J.-M. Dinten, L. Saroul, F. Duboeuf, and D. Vray, “Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis,” J. Biomed. Opt.14(6), 064001 (2009).
[CrossRef] [PubMed]

H. Zhao, F. Gao, Y. Tanikawa, and Y. Yamada, “Time-resolved diffuse optical tomography and its application to in vitro and in vivo imaging,” J. Biomed. Opt.12(6), 062107 (2007).
[CrossRef] [PubMed]

J. C. Hebden, F. M. Gonzalez, A. Gibson, E. M. C. Hillman, R. M. Yusof, N. Everdell, D. T. Delpy, G. Zaccanti, and F. Martelli, “Assessment of an in situ temporal calibration method for time-resolved optical tomography,” J. Biomed. Opt.8(1), 87–92 (2003).
[CrossRef] [PubMed]

Med. Phys. (2)

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys.35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

J. Riley, M. Hassan, V. Chernomordik, and A. Gandjbakhche, “Choice of data types in time resolved fluorescence enhanced diffuse optical tomography,” Med. Phys.34(12), 4890–4900 (2007).
[CrossRef] [PubMed]

Neuroimage (1)

T. Austin, A. P. Gibson, G. Branco, R. M. Yusof, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain,” Neuroimage31(4), 1426–1433 (2006).
[CrossRef] [PubMed]

Opt. Express (2)

Opto-Electron. Rev. (1)

M. Kacprzak, A. Liebert, P. Sawosz, N. Zolek, D. Milej, and R. Maniewski, “Time-resolved imaging of fluorescent inclusions in optically turbid medium – phantom study,” Opto-Electron. Rev.18(1), 37–47 (2010).
[CrossRef]

Phys. Med. Biol. (7)

T. Durduran, R. Choe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, “Bulk optical properties of healthy female breast tissue,” Phys. Med. Biol.47(16), 2847–2861 (2002).
[CrossRef] [PubMed]

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J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol.47(23), 4155–4166 (2002).
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Proc. SPIE (1)

R. M. Yusof, J. C. Hebden, A. Gibson, N. Everdell, T. Austin, J. H. Meek, S. R. Arridge, J. S. Wyatt, and D. T. Delpy, “Validation of the use of homogenous reference phantoms for optical tomography of the neonatal brain,” Proc. SPIE4955, 6–11 (2003).

Rev. Sci. Instrum. (1)

E. M. C. Hillman, J. C. Hebden, F. E. W. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum.71(9), 3415–3427 (2000).
[CrossRef]

Other (1)

J. C. Hebden, M. Varela, S. Magazov, N. Everdell, A. Gibson, J. Meek, and T. Austin, “Diffuse optical imaging of the newborn infant brain,” in 2012 9th IEEE International Symposium on Biomedical Imaging (ISBI) (IEEE, 2012), pp. 503–505.

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Figures (13)

Fig. 1
Fig. 1

Schematic view of the followed algorithm for tomographic reconstruction.

Fig. 2
Fig. 2

(a) An example of 2D reconstructed map of µa in the medium. (b) The 50% spot and the extracted parameters: x and z position of its center of mass and the mean µa in this spot.

Fig. 3
Fig. 3

Numerical 2D phantom and probe (crosses: sources “S”, circles: detectors “D”, large grey disc: absorption inclusion). The mesh is represented only in 1 cm2. Only the couples S1D2 and S2D1 are used for the analysis.

Fig. 4
Fig. 4

Simulated signals without the inclusion (red) and with the inclusion at 2 cm depth (blue), (a) 106 photons after DCR correction, (b) 108 photons after DCR correction. For all: 1 noise realization only.

Fig. 5
Fig. 5

Contrast on MLT orders (p = 3 ns−1) for the different depths for S1D2, (a) 106 photons, (b) 108 photons (error bars are obtained from the 10 noise realizations).

Fig. 6
Fig. 6

Reconstructed depth versus true depth for different choices of maximum orders of MLT included for the reconstruction, (a) 106 photons, (b) 108 photons (error bars obtained from the 10 noise realizations).

Fig. 7
Fig. 7

Reconstructed images of µa for 106 photons and 108 photons (one noise realization). The red dotted circle depicts the true position and size of the absorbing inclusion.

Fig. 8
Fig. 8

Summarized reconstruction performances for 106 and 108 photons for 10 noise realizations, (a) reconstructed depth, (b) x localization, (c) Mean reconstructed µa.

Fig. 9
Fig. 9

TCSPC setup, probe and optical phantom.

Fig. 10
Fig. 10

Raw signals (after DCR correction) for S1D2, (a) All references, (b) All “depth” measurements (depth 1 acquired between refs [1] and [2], etc.).

Fig. 11
Fig. 11

Contrast on MLT orders for different depths of the absorbing inclusion.

Fig. 12
Fig. 12

Summarized reconstruction performances for experimental signals with an acquisition time of 1 s, (a) reconstructed depth, (b) x localization, (c) Mean reconstructed µa.

Fig. 13
Fig. 13

Reconstructed images at iteration 15 for all depths of the inclusion, for 2 different references. From 10 to 20 mm, the reconstructed images are similar for both references. From 25 mm to deeper, analogous reconstructions obtained with the 2 different references differ very much: they are driven by photonic noise.

Equations (9)

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G s β ( r d ,t) G s α ( r d ,t)= Ω G s α ( r ,t)δ μ a ( r ) G d β ( r ,t)d r
f (p,n) = M (p,n) [ f(t) ]= p n n! 0 + f(t) t n exp(pt)dt
(abcd) (p,n) (t)= i+j+l+m=n a (p,i) × b (p,j) × c (p,l) × d (p,m)
A sd (t)=IR F sd (t) G sd A (t) B sd (t)=IR F sd (t) G sd B (t)
A sd (t) G sd B (t)= B sd (t) G sd A (t)
G sd B (t) G sd,k B (t)= Ω G s,k B ( r ,t)δ μ a,k ( r ) G d,k B ( r ,t)d r
B sd (t) G sd A (t) A sd (t) G sd,k B (t)= A sd (t) Ω G s,k B ( r ,t) δ μ a,k ( r ) G d,k B ( r ,t)d r
e+f=n B sd (p,e) G sd A(p,f) A sd (p,e) G sd,k B(p,f) = i+j+l=n A sd (p,i) Ω G s,k B(p,j) ( r )δ μ a,k ( r ) G d,k B(p,l) ( r )d r
Contrast= ML T without_inclusion ML T with_inclusion ML T without_inclusion ×100

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