G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
E. Chuang, D. Barnard, L. Hettich, X. F. Zhang, J. Avruch, and M. S. Marshall, “Critical binding and regulatory interactions
between Ras and Raf occur through a small, stable N-terminal domain of Raf
and specific Ras effector residues,” Mol. Cel.
Biol. 8, 359091 (1994).
J. A. Avruch, A. Khokhlatchev, J. M. Kyriakis, Z. Luo, G. Tzivion, D. Vavvas, and X. F. Zhang, “Ras activation of the Raf kinase: tyrosine
kinase recruitment of the MAP kinase cascade,” Recent Prog. Horm. Res. 56(1), 127–156 (2001).
[Crossref]
[PubMed]
E. Chuang, D. Barnard, L. Hettich, X. F. Zhang, J. Avruch, and M. S. Marshall, “Critical binding and regulatory interactions
between Ras and Raf occur through a small, stable N-terminal domain of Raf
and specific Ras effector residues,” Mol. Cel.
Biol. 8, 359091 (1994).
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
G. I. Bell, “Models for the specific adhesion of cells to
cells,” Science 200(4342), 618–627 (1978).
[Crossref]
[PubMed]
T. R. Brtva, J. K. Drugan, S. Ghosh, R. S. Terrell, S. Campbell-Burk, R. M. Bell, and C. J. Der, “Two Distinct Raf Domains Mediate Interaction
with Ras,” J. Biol. Chem. 270(17), 9809–9812 (1995).
[Crossref]
[PubMed]
S. Ghosh, W. Q. Xie, A. F. Quest, G. M. Mabrouk, J. C. Strum, and R. M. Bell, “The cysteine-rich region of raf-1 kinase
contain zinc, translocates to liposomes, and is adjacent to a segment that
binds GTP-ras,” J. Biol. Chem. 4, 8144497 (1994).
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
M. L. Bennink, S. H. Leuba, G. H. Leno, J. Zlatanova, B. G. de Grooth, and J. Greve, “Unfolding individual nucleosomes by stretching
single chromatin fibers with optical tweezers,” Nat.
Struct. Biol. 8(7), 606–610 (2001).
[Crossref]
[PubMed]
F. Bordeleau, J. Bessard, N. Marceau, and Y. Sheng, “Measuring integrated cellular mechanical stress
response at focal adhesions by optical tweezers,” J.
Biomed. Opt. 16(9), 095005 (2011).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
M. D. Wang, M. J. Schnitzer, H. Yin, R. Landick, J. Gelles, and S. M. Block, “Force and velocity measured for single
molecules of RNA polymerase,” Science 282(5390), 902–907 (1998).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
F. Bordeleau, J. Bessard, N. Marceau, and Y. Sheng, “Measuring integrated cellular mechanical stress
response at focal adhesions by optical tweezers,” J.
Biomed. Opt. 16(9), 095005 (2011).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
T. R. Brtva, J. K. Drugan, S. Ghosh, R. S. Terrell, S. Campbell-Burk, R. M. Bell, and C. J. Der, “Two Distinct Raf Domains Mediate Interaction
with Ras,” J. Biol. Chem. 270(17), 9809–9812 (1995).
[Crossref]
[PubMed]
C. Bustamante, Z. Bryant, and S. B. Smith, “Ten years of tension: single-molecule DNA
mechanics,” Nature 421(6921), 423–427 (2003).
[Crossref]
[PubMed]
C. Bustamante, Z. Bryant, and S. B. Smith, “Ten years of tension: single-molecule DNA
mechanics,” Nature 421(6921), 423–427 (2003).
[Crossref]
[PubMed]
T. R. Brtva, J. K. Drugan, S. Ghosh, R. S. Terrell, S. Campbell-Burk, R. M. Bell, and C. J. Der, “Two Distinct Raf Domains Mediate Interaction
with Ras,” J. Biol. Chem. 270(17), 9809–9812 (1995).
[Crossref]
[PubMed]
M. Carrion-Vazquez, A. F. Oberhauser, T. E. Fisher, P. E. Marszalek, H. Li, and J. M. Fernandez, “Mechanical design of proteins studied by
single-molecule force spectroscopy and protein engineering,” Prog. Biophys. Mol. Biol. 74(1-2), 63–91 (2000).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
E. Chuang, D. Barnard, L. Hettich, X. F. Zhang, J. Avruch, and M. S. Marshall, “Critical binding and regulatory interactions
between Ras and Raf occur through a small, stable N-terminal domain of Raf
and specific Ras effector residues,” Mol. Cel.
Biol. 8, 359091 (1994).
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
A. B. Vojtek, S. M. Hollenberg, and J. A. Cooper, “Mammalian RAS interacts directly with the
serine/threonine kinase raf,” Cell 74(1), 205–214 (1993).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
M. L. Bennink, S. H. Leuba, G. H. Leno, J. Zlatanova, B. G. de Grooth, and J. Greve, “Unfolding individual nucleosomes by stretching
single chromatin fibers with optical tweezers,” Nat.
Struct. Biol. 8(7), 606–610 (2001).
[Crossref]
[PubMed]
T. R. Brtva, J. K. Drugan, S. Ghosh, R. S. Terrell, S. Campbell-Burk, R. M. Bell, and C. J. Der, “Two Distinct Raf Domains Mediate Interaction
with Ras,” J. Biol. Chem. 270(17), 9809–9812 (1995).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
T. R. Brtva, J. K. Drugan, S. Ghosh, R. S. Terrell, S. Campbell-Burk, R. M. Bell, and C. J. Der, “Two Distinct Raf Domains Mediate Interaction
with Ras,” J. Biol. Chem. 270(17), 9809–9812 (1995).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
T. Erdmann, S. Pierrat, P. Nassoy, and U. S. Schwarz, “Dynamic force spectroscopy on multiple bonds:
Experiments and model,” Europhys. Lett. 81(4), 48001 (2008).
[Crossref]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
C. Peyssonnaux and A. Eychène, “The Raf/MEK/ERK pathway: new concepts of
activation,” Biol. Cell 93(1-2), 53–62 (2001).
[Crossref]
[PubMed]
M. Carrion-Vazquez, A. F. Oberhauser, T. E. Fisher, P. E. Marszalek, H. Li, and J. M. Fernandez, “Mechanical design of proteins studied by
single-molecule force spectroscopy and protein engineering,” Prog. Biophys. Mol. Biol. 74(1-2), 63–91 (2000).
[Crossref]
[PubMed]
M. Carrion-Vazquez, A. F. Oberhauser, T. E. Fisher, P. E. Marszalek, H. Li, and J. M. Fernandez, “Mechanical design of proteins studied by
single-molecule force spectroscopy and protein engineering,” Prog. Biophys. Mol. Biol. 74(1-2), 63–91 (2000).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
M. D. Wang, M. J. Schnitzer, H. Yin, R. Landick, J. Gelles, and S. M. Block, “Force and velocity measured for single
molecules of RNA polymerase,” Science 282(5390), 902–907 (1998).
[Crossref]
[PubMed]
T. R. Brtva, J. K. Drugan, S. Ghosh, R. S. Terrell, S. Campbell-Burk, R. M. Bell, and C. J. Der, “Two Distinct Raf Domains Mediate Interaction
with Ras,” J. Biol. Chem. 270(17), 9809–9812 (1995).
[Crossref]
[PubMed]
S. Ghosh, W. Q. Xie, A. F. Quest, G. M. Mabrouk, J. C. Strum, and R. M. Bell, “The cysteine-rich region of raf-1 kinase
contain zinc, translocates to liposomes, and is adjacent to a segment that
binds GTP-ras,” J. Biol. Chem. 4, 8144497 (1994).
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
M. L. Bennink, S. H. Leuba, G. H. Leno, J. Zlatanova, B. G. de Grooth, and J. Greve, “Unfolding individual nucleosomes by stretching
single chromatin fibers with optical tweezers,” Nat.
Struct. Biol. 8(7), 606–610 (2001).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
E. Chuang, D. Barnard, L. Hettich, X. F. Zhang, J. Avruch, and M. S. Marshall, “Critical binding and regulatory interactions
between Ras and Raf occur through a small, stable N-terminal domain of Raf
and specific Ras effector residues,” Mol. Cel.
Biol. 8, 359091 (1994).
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
A. B. Vojtek, S. M. Hollenberg, and J. A. Cooper, “Mammalian RAS interacts directly with the
serine/threonine kinase raf,” Cell 74(1), 205–214 (1993).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
M. Salomo, U. F. Keyser, M. Struhalla, and F. Kremer, “Optical tweezers to study single Protein
A/Immunoglobulin G interactions at varying conditions,” Eur. Biophys. J. 37(6), 927–934 (2008).
[Crossref]
[PubMed]
J. A. Avruch, A. Khokhlatchev, J. M. Kyriakis, Z. Luo, G. Tzivion, D. Vavvas, and X. F. Zhang, “Ras activation of the Raf kinase: tyrosine
kinase recruitment of the MAP kinase cascade,” Recent Prog. Horm. Res. 56(1), 127–156 (2001).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
W. Kolch, “Meaningful relationships: the regulation of the
Ras/Raf/MEK/ERK pathway by protein interactions,” Biochem. J. 351(2), 289–305 (2000).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
M. Salomo, U. F. Keyser, M. Struhalla, and F. Kremer, “Optical tweezers to study single Protein
A/Immunoglobulin G interactions at varying conditions,” Eur. Biophys. J. 37(6), 927–934 (2008).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
J. A. Avruch, A. Khokhlatchev, J. M. Kyriakis, Z. Luo, G. Tzivion, D. Vavvas, and X. F. Zhang, “Ras activation of the Raf kinase: tyrosine
kinase recruitment of the MAP kinase cascade,” Recent Prog. Horm. Res. 56(1), 127–156 (2001).
[Crossref]
[PubMed]
M. D. Wang, M. J. Schnitzer, H. Yin, R. Landick, J. Gelles, and S. M. Block, “Force and velocity measured for single
molecules of RNA polymerase,” Science 282(5390), 902–907 (1998).
[Crossref]
[PubMed]
M. L. Bennink, S. H. Leuba, G. H. Leno, J. Zlatanova, B. G. de Grooth, and J. Greve, “Unfolding individual nucleosomes by stretching
single chromatin fibers with optical tweezers,” Nat.
Struct. Biol. 8(7), 606–610 (2001).
[Crossref]
[PubMed]
M. L. Bennink, S. H. Leuba, G. H. Leno, J. Zlatanova, B. G. de Grooth, and J. Greve, “Unfolding individual nucleosomes by stretching
single chromatin fibers with optical tweezers,” Nat.
Struct. Biol. 8(7), 606–610 (2001).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
M. Carrion-Vazquez, A. F. Oberhauser, T. E. Fisher, P. E. Marszalek, H. Li, and J. M. Fernandez, “Mechanical design of proteins studied by
single-molecule force spectroscopy and protein engineering,” Prog. Biophys. Mol. Biol. 74(1-2), 63–91 (2000).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
J. A. Avruch, A. Khokhlatchev, J. M. Kyriakis, Z. Luo, G. Tzivion, D. Vavvas, and X. F. Zhang, “Ras activation of the Raf kinase: tyrosine
kinase recruitment of the MAP kinase cascade,” Recent Prog. Horm. Res. 56(1), 127–156 (2001).
[Crossref]
[PubMed]
S. Ghosh, W. Q. Xie, A. F. Quest, G. M. Mabrouk, J. C. Strum, and R. M. Bell, “The cysteine-rich region of raf-1 kinase
contain zinc, translocates to liposomes, and is adjacent to a segment that
binds GTP-ras,” J. Biol. Chem. 4, 8144497 (1994).
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
F. Bordeleau, J. Bessard, N. Marceau, and Y. Sheng, “Measuring integrated cellular mechanical stress
response at focal adhesions by optical tweezers,” J.
Biomed. Opt. 16(9), 095005 (2011).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
E. Chuang, D. Barnard, L. Hettich, X. F. Zhang, J. Avruch, and M. S. Marshall, “Critical binding and regulatory interactions
between Ras and Raf occur through a small, stable N-terminal domain of Raf
and specific Ras effector residues,” Mol. Cel.
Biol. 8, 359091 (1994).
M. Carrion-Vazquez, A. F. Oberhauser, T. E. Fisher, P. E. Marszalek, H. Li, and J. M. Fernandez, “Mechanical design of proteins studied by
single-molecule force spectroscopy and protein engineering,” Prog. Biophys. Mol. Biol. 74(1-2), 63–91 (2000).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
K. C. Neuman and A. Nagy, “Single-molecular force spectroscopy: optical
tweezers, magnetic tweezers and atomic force microscopy,” Nature Meth. 5, 1218 (2008).
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
T. Erdmann, S. Pierrat, P. Nassoy, and U. S. Schwarz, “Dynamic force spectroscopy on multiple bonds:
Experiments and model,” Europhys. Lett. 81(4), 48001 (2008).
[Crossref]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
K. C. Neuman and A. Nagy, “Single-molecular force spectroscopy: optical
tweezers, magnetic tweezers and atomic force microscopy,” Nature Meth. 5, 1218 (2008).
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
M. Carrion-Vazquez, A. F. Oberhauser, T. E. Fisher, P. E. Marszalek, H. Li, and J. M. Fernandez, “Mechanical design of proteins studied by
single-molecule force spectroscopy and protein engineering,” Prog. Biophys. Mol. Biol. 74(1-2), 63–91 (2000).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
C. Peyssonnaux and A. Eychène, “The Raf/MEK/ERK pathway: new concepts of
activation,” Biol. Cell 93(1-2), 53–62 (2001).
[Crossref]
[PubMed]
T. Erdmann, S. Pierrat, P. Nassoy, and U. S. Schwarz, “Dynamic force spectroscopy on multiple bonds:
Experiments and model,” Europhys. Lett. 81(4), 48001 (2008).
[Crossref]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
S. Ghosh, W. Q. Xie, A. F. Quest, G. M. Mabrouk, J. C. Strum, and R. M. Bell, “The cysteine-rich region of raf-1 kinase
contain zinc, translocates to liposomes, and is adjacent to a segment that
binds GTP-ras,” J. Biol. Chem. 4, 8144497 (1994).
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
M. Salomo, U. F. Keyser, M. Struhalla, and F. Kremer, “Optical tweezers to study single Protein
A/Immunoglobulin G interactions at varying conditions,” Eur. Biophys. J. 37(6), 927–934 (2008).
[Crossref]
[PubMed]
M. D. Wang, M. J. Schnitzer, H. Yin, R. Landick, J. Gelles, and S. M. Block, “Force and velocity measured for single
molecules of RNA polymerase,” Science 282(5390), 902–907 (1998).
[Crossref]
[PubMed]
T. Erdmann, S. Pierrat, P. Nassoy, and U. S. Schwarz, “Dynamic force spectroscopy on multiple bonds:
Experiments and model,” Europhys. Lett. 81(4), 48001 (2008).
[Crossref]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
F. Bordeleau, J. Bessard, N. Marceau, and Y. Sheng, “Measuring integrated cellular mechanical stress
response at focal adhesions by optical tweezers,” J.
Biomed. Opt. 16(9), 095005 (2011).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
C. Bustamante, Z. Bryant, and S. B. Smith, “Ten years of tension: single-molecule DNA
mechanics,” Nature 421(6921), 423–427 (2003).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
Q. Song, C. Wen, Y. Zhang, G. Wang, and A. Ye, “Calibration of optical tweezers based on
acousto-optic deflector and field programmable gate array,” Chin. Opt. Lett. 6, 1671–7694 (2008).
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
M. Salomo, U. F. Keyser, M. Struhalla, and F. Kremer, “Optical tweezers to study single Protein
A/Immunoglobulin G interactions at varying conditions,” Eur. Biophys. J. 37(6), 927–934 (2008).
[Crossref]
[PubMed]
S. Ghosh, W. Q. Xie, A. F. Quest, G. M. Mabrouk, J. C. Strum, and R. M. Bell, “The cysteine-rich region of raf-1 kinase
contain zinc, translocates to liposomes, and is adjacent to a segment that
binds GTP-ras,” J. Biol. Chem. 4, 8144497 (1994).
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
T. R. Brtva, J. K. Drugan, S. Ghosh, R. S. Terrell, S. Campbell-Burk, R. M. Bell, and C. J. Der, “Two Distinct Raf Domains Mediate Interaction
with Ras,” J. Biol. Chem. 270(17), 9809–9812 (1995).
[Crossref]
[PubMed]
J. A. Avruch, A. Khokhlatchev, J. M. Kyriakis, Z. Luo, G. Tzivion, D. Vavvas, and X. F. Zhang, “Ras activation of the Raf kinase: tyrosine
kinase recruitment of the MAP kinase cascade,” Recent Prog. Horm. Res. 56(1), 127–156 (2001).
[Crossref]
[PubMed]
J. A. Avruch, A. Khokhlatchev, J. M. Kyriakis, Z. Luo, G. Tzivion, D. Vavvas, and X. F. Zhang, “Ras activation of the Raf kinase: tyrosine
kinase recruitment of the MAP kinase cascade,” Recent Prog. Horm. Res. 56(1), 127–156 (2001).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
A. B. Vojtek, S. M. Hollenberg, and J. A. Cooper, “Mammalian RAS interacts directly with the
serine/threonine kinase raf,” Cell 74(1), 205–214 (1993).
[Crossref]
[PubMed]
Q. Song, C. Wen, Y. Zhang, G. Wang, and A. Ye, “Calibration of optical tweezers based on
acousto-optic deflector and field programmable gate array,” Chin. Opt. Lett. 6, 1671–7694 (2008).
M. D. Wang, M. J. Schnitzer, H. Yin, R. Landick, J. Gelles, and S. M. Block, “Force and velocity measured for single
molecules of RNA polymerase,” Science 282(5390), 902–907 (1998).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
Q. Song, C. Wen, Y. Zhang, G. Wang, and A. Ye, “Calibration of optical tweezers based on
acousto-optic deflector and field programmable gate array,” Chin. Opt. Lett. 6, 1671–7694 (2008).
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. C. M. Hennekam, G. Gillessen-Kaesbach, D. Wieczorek, M. I. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, K. Kato, S. Kure, and Y. Matsubara, “Germline KRAS and BRAF mutations in
cardio-facio-cutaneous syndrome,” Nat.
Genet. 38(3), 294–296 (2006).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
S. Ghosh, W. Q. Xie, A. F. Quest, G. M. Mabrouk, J. C. Strum, and R. M. Bell, “The cysteine-rich region of raf-1 kinase
contain zinc, translocates to liposomes, and is adjacent to a segment that
binds GTP-ras,” J. Biol. Chem. 4, 8144497 (1994).
Q. Song, C. Wen, Y. Zhang, G. Wang, and A. Ye, “Calibration of optical tweezers based on
acousto-optic deflector and field programmable gate array,” Chin. Opt. Lett. 6, 1671–7694 (2008).
G. Hatzivassiliou, K. Song, I. Yen, B. J. Brandhuber, D. J. Anderson, R. Alvarado, M. J. C. Ludlam, D. Stokoe, S. L. Gloor, G. Vigers, T. Morales, I. Aliagas, B. Liu, S. Sideris, K. P. Hoeflich, B. S. Jaiswal, S. Seshagiri, H. Koeppen, M. Belvin, L. S. Friedman, and S. Malek, “RAF inhibitors prime wild-type RAF to activate
the MAPK pathway and enhance growth,” Nature 464(7287), 431–435 (2010).
[Crossref]
[PubMed]
M. D. Wang, M. J. Schnitzer, H. Yin, R. Landick, J. Gelles, and S. M. Block, “Force and velocity measured for single
molecules of RNA polymerase,” Science 282(5390), 902–907 (1998).
[Crossref]
[PubMed]
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, and P. A. Futreal, “Mutations of the BRAF gene in human
cancer,” Nature 417(6892), 949–954 (2002).
[Crossref]
[PubMed]
J. A. Avruch, A. Khokhlatchev, J. M. Kyriakis, Z. Luo, G. Tzivion, D. Vavvas, and X. F. Zhang, “Ras activation of the Raf kinase: tyrosine
kinase recruitment of the MAP kinase cascade,” Recent Prog. Horm. Res. 56(1), 127–156 (2001).
[Crossref]
[PubMed]
E. Chuang, D. Barnard, L. Hettich, X. F. Zhang, J. Avruch, and M. S. Marshall, “Critical binding and regulatory interactions
between Ras and Raf occur through a small, stable N-terminal domain of Raf
and specific Ras effector residues,” Mol. Cel.
Biol. 8, 359091 (1994).
Q. Song, C. Wen, Y. Zhang, G. Wang, and A. Ye, “Calibration of optical tweezers based on
acousto-optic deflector and field programmable gate array,” Chin. Opt. Lett. 6, 1671–7694 (2008).
M. L. Bennink, S. H. Leuba, G. H. Leno, J. Zlatanova, B. G. de Grooth, and J. Greve, “Unfolding individual nucleosomes by stretching
single chromatin fibers with optical tweezers,” Nat.
Struct. Biol. 8(7), 606–610 (2001).
[Crossref]
[PubMed]