Abstract

In a pilot study, multimodal optical spectroscopy coupled with quantitative tissue-optics models distinguished intraductal papillary mucinous neoplasm (IPMN), a common precursor to pancreatic cancer, from normal tissues in freshly excised human pancreas. A photon-tissue interaction (PTI) model extracted parameters associated with cellular nuclear size and refractive index (from reflectance spectra) and extracellular collagen content (from fluorescence spectra). The results suggest that tissue optical spectroscopy has the potential to characterize pre-cancerous neoplasms in human pancreatic tissues.

© 2013 Optical Society of America

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    [CrossRef] [PubMed]

2012

M. Erkan, S. Hausmann, C. W. Michalski, A. A. Fingerle, M. Dobritz, J. Kleeff, and H. Friess, “The role of stroma in pancreatic cancer: diagnostic and therapeutic implications,” Nat. Rev. Gastroenterol. Hepatol.9(8), 454–467 (2012).
[CrossRef] [PubMed]

2011

R. H. Wilson and M.-A. Mycek, “Models of light propagation in human tissue applied to cancer diagnostics,” Technol. Cancer Res. Treat.10(2), 121–134 (2011).
[PubMed]

R. K. Bista, S. Uttam, P. Wang, K. Staton, S. Choi, C. J. Bakkenist, D. J. Hartman, R. E. Brand, and Y. Liu, “Quantification of nanoscale nuclear refractive index changes during the cell cycle,” J. Biomed. Opt.16(7), 070503 (2011).
[CrossRef] [PubMed]

2010

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. C. M. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt.15(1), 017004 (2010).
[CrossRef] [PubMed]

M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek, “Spectral areas and ratios classifier algorithm for pancreatic tissue classification using optical spectroscopy,” J. Biomed. Opt.15(1), 010514 (2010).
[CrossRef] [PubMed]

R. H. Wilson, M. Chandra, L. C. Chen, W. R. Lloyd, J. Scheiman, D. Simeone, J. Purdy, B. McKenna, and M.-A. Mycek, “Photon-tissue interaction model enables quantitative optical analysis of human pancreatic tissues,” Opt. Express18(21), 21612–21621 (2010).
[CrossRef] [PubMed]

2009

R. H. Wilson, M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek, “Optical spectroscopy detects histological hallmarks of pancreatic cancer,” Opt. Express17(20), 17502–17516 (2009).
[CrossRef] [PubMed]

C. Lau, O. Sćepanović, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, “Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy,” J. Biomed. Opt.14(2), 024031 (2009).
[CrossRef] [PubMed]

C. R. Ferrone, C. Correa-Gallego, A. L. Warshaw, W. R. Brugge, D. G. Forcione, S. P. Thayer, and C. Fernández-del Castillo, “Current Trends in Pancreatic Cystic Neoplasms,” Arch. Surg.144(5), 448–454 (2009).
[CrossRef] [PubMed]

V. T.-C. Chang, P. S. Cartwright, S. M. Bean, G. M. Palmer, R. C. Bentley, and N. Ramanujam, “Quantitative physiology of the precancerous cervix in vivo through optical spectroscopy,” Neoplasia11(4), 325–332 (2009).
[PubMed]

2008

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt.13(2), 024012 (2008).
[CrossRef] [PubMed]

2007

M. Chandra, J. Scheiman, D. Heidt, D. Simeone, B. McKenna, and M.-A. Mycek, “Probing pancreatic disease using tissue optical spectroscopy,” J. Biomed. Opt.12(6), 060501 (2007).
[CrossRef] [PubMed]

2006

2005

M. A. Eloubeidi and A. Tamhane, “EUS-guided FNA of solid pancreatic masses: a learning curve with 300 consecutive procedures,” Gastrointest. Endosc.61(6), 700–708 (2005).
[CrossRef] [PubMed]

2004

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

T. Baba, T. Yamaguchi, T. Ishihara, A. Kobayashi, T. Oshima, N. Sakaue, K. Kato, M. Ebara, and H. Saisho, “Distinguishing benign from malignant intraductal papillary mucinous tumors of the pancreas by imaging techniques,” Pancreas29(3), 212–217 (2004).
[CrossRef] [PubMed]

A. Amelink, H. J. C. M. Sterenborg, M. P. L. Bard, and S. A. Burgers, “In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy,” Opt. Lett.29(10), 1087–1089 (2004).
[CrossRef] [PubMed]

2003

R. Drezek, M. Guillaud, T. Collier, I. Boiko, A. Malpica, C. Macaulay, M. Follen, and R. Richards-Kortum, “Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture,” J. Biomed. Opt.8(1), 7–16 (2003).
[CrossRef] [PubMed]

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

1998

M.-A. Mycek, K. T. Schomacker, and N. S. Nishioka, “Colonic polyp differentiation using time-resolved autofluorescence spectroscopy,” Gastrointest. Endosc.48(4), 390–394 (1998).
[CrossRef] [PubMed]

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Adsay, N. V.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Aerts, J. G. J. V.

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. C. M. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt.15(1), 017004 (2010).
[CrossRef] [PubMed]

Albores-Saavedra, J.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Amelink, A.

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. C. M. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt.15(1), 017004 (2010).
[CrossRef] [PubMed]

A. Amelink, H. J. C. M. Sterenborg, M. P. L. Bard, and S. A. Burgers, “In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy,” Opt. Lett.29(10), 1087–1089 (2004).
[CrossRef] [PubMed]

Aubert, A.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

Baba, T.

T. Baba, T. Yamaguchi, T. Ishihara, A. Kobayashi, T. Oshima, N. Sakaue, K. Kato, M. Ebara, and H. Saisho, “Distinguishing benign from malignant intraductal papillary mucinous tumors of the pancreas by imaging techniques,” Pancreas29(3), 212–217 (2004).
[CrossRef] [PubMed]

Backman, V.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Bakkenist, C. J.

R. K. Bista, S. Uttam, P. Wang, K. Staton, S. Choi, C. J. Bakkenist, D. J. Hartman, R. E. Brand, and Y. Liu, “Quantification of nanoscale nuclear refractive index changes during the cell cycle,” J. Biomed. Opt.16(7), 070503 (2011).
[CrossRef] [PubMed]

Bard, M. P. L.

Bean, S. M.

V. T.-C. Chang, P. S. Cartwright, S. M. Bean, G. M. Palmer, R. C. Bentley, and N. Ramanujam, “Quantitative physiology of the precancerous cervix in vivo through optical spectroscopy,” Neoplasia11(4), 325–332 (2009).
[PubMed]

Bechtel, K.

C. Lau, O. Sćepanović, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, “Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy,” J. Biomed. Opt.14(2), 024031 (2009).
[CrossRef] [PubMed]

Bechtel, K. L.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt.13(2), 024012 (2008).
[CrossRef] [PubMed]

Bentley, R. C.

V. T.-C. Chang, P. S. Cartwright, S. M. Bean, G. M. Palmer, R. C. Bentley, and N. Ramanujam, “Quantitative physiology of the precancerous cervix in vivo through optical spectroscopy,” Neoplasia11(4), 325–332 (2009).
[PubMed]

Biankin, A. V.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Biankin, S. A.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Bista, R. K.

R. K. Bista, S. Uttam, P. Wang, K. Staton, S. Choi, C. J. Bakkenist, D. J. Hartman, R. E. Brand, and Y. Liu, “Quantification of nanoscale nuclear refractive index changes during the cell cycle,” J. Biomed. Opt.16(7), 070503 (2011).
[CrossRef] [PubMed]

Boiko, I.

R. Drezek, M. Guillaud, T. Collier, I. Boiko, A. Malpica, C. Macaulay, M. Follen, and R. Richards-Kortum, “Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture,” J. Biomed. Opt.8(1), 7–16 (2003).
[CrossRef] [PubMed]

Brand, R. E.

R. K. Bista, S. Uttam, P. Wang, K. Staton, S. Choi, C. J. Bakkenist, D. J. Hartman, R. E. Brand, and Y. Liu, “Quantification of nanoscale nuclear refractive index changes during the cell cycle,” J. Biomed. Opt.16(7), 070503 (2011).
[CrossRef] [PubMed]

Brugge, W. R.

C. R. Ferrone, C. Correa-Gallego, A. L. Warshaw, W. R. Brugge, D. G. Forcione, S. P. Thayer, and C. Fernández-del Castillo, “Current Trends in Pancreatic Cystic Neoplasms,” Arch. Surg.144(5), 448–454 (2009).
[CrossRef] [PubMed]

Burgers, S. A.

Cartwright, P. S.

V. T.-C. Chang, P. S. Cartwright, S. M. Bean, G. M. Palmer, R. C. Bentley, and N. Ramanujam, “Quantitative physiology of the precancerous cervix in vivo through optical spectroscopy,” Neoplasia11(4), 325–332 (2009).
[PubMed]

Chandra, M.

Chang, V. T.-C.

V. T.-C. Chang, P. S. Cartwright, S. M. Bean, G. M. Palmer, R. C. Bentley, and N. Ramanujam, “Quantitative physiology of the precancerous cervix in vivo through optical spectroscopy,” Neoplasia11(4), 325–332 (2009).
[PubMed]

Chen, L. C.

Choi, S.

R. K. Bista, S. Uttam, P. Wang, K. Staton, S. Choi, C. J. Bakkenist, D. J. Hartman, R. E. Brand, and Y. Liu, “Quantification of nanoscale nuclear refractive index changes during the cell cycle,” J. Biomed. Opt.16(7), 070503 (2011).
[CrossRef] [PubMed]

Collier, T.

R. Drezek, M. Guillaud, T. Collier, I. Boiko, A. Malpica, C. Macaulay, M. Follen, and R. Richards-Kortum, “Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture,” J. Biomed. Opt.8(1), 7–16 (2003).
[CrossRef] [PubMed]

Compton, C.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Correa-Gallego, C.

C. R. Ferrone, C. Correa-Gallego, A. L. Warshaw, W. R. Brugge, D. G. Forcione, S. P. Thayer, and C. Fernández-del Castillo, “Current Trends in Pancreatic Cystic Neoplasms,” Arch. Surg.144(5), 448–454 (2009).
[CrossRef] [PubMed]

Couvelard, A.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

Crawford, J. M.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Dancour, A.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

Dasari, R. R.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt.13(2), 024012 (2008).
[CrossRef] [PubMed]

Degott, C.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

Dobritz, M.

M. Erkan, S. Hausmann, C. W. Michalski, A. A. Fingerle, M. Dobritz, J. Kleeff, and H. Friess, “The role of stroma in pancreatic cancer: diagnostic and therapeutic implications,” Nat. Rev. Gastroenterol. Hepatol.9(8), 454–467 (2012).
[CrossRef] [PubMed]

Drezek, R.

R. Drezek, M. Guillaud, T. Collier, I. Boiko, A. Malpica, C. Macaulay, M. Follen, and R. Richards-Kortum, “Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture,” J. Biomed. Opt.8(1), 7–16 (2003).
[CrossRef] [PubMed]

Ebara, M.

T. Baba, T. Yamaguchi, T. Ishihara, A. Kobayashi, T. Oshima, N. Sakaue, K. Kato, M. Ebara, and H. Saisho, “Distinguishing benign from malignant intraductal papillary mucinous tumors of the pancreas by imaging techniques,” Pancreas29(3), 212–217 (2004).
[CrossRef] [PubMed]

Eloubeidi, M. A.

M. A. Eloubeidi and A. Tamhane, “EUS-guided FNA of solid pancreatic masses: a learning curve with 300 consecutive procedures,” Gastrointest. Endosc.61(6), 700–708 (2005).
[CrossRef] [PubMed]

Erkan, M.

M. Erkan, S. Hausmann, C. W. Michalski, A. A. Fingerle, M. Dobritz, J. Kleeff, and H. Friess, “The role of stroma in pancreatic cancer: diagnostic and therapeutic implications,” Nat. Rev. Gastroenterol. Hepatol.9(8), 454–467 (2012).
[CrossRef] [PubMed]

Felce-Dachez, M.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

Feld, M.

C. Lau, O. Sćepanović, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, “Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy,” J. Biomed. Opt.14(2), 024031 (2009).
[CrossRef] [PubMed]

Feld, M. S.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt.13(2), 024012 (2008).
[CrossRef] [PubMed]

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Fernández-del Castillo, C.

C. R. Ferrone, C. Correa-Gallego, A. L. Warshaw, W. R. Brugge, D. G. Forcione, S. P. Thayer, and C. Fernández-del Castillo, “Current Trends in Pancreatic Cystic Neoplasms,” Arch. Surg.144(5), 448–454 (2009).
[CrossRef] [PubMed]

Ferrone, C. R.

C. R. Ferrone, C. Correa-Gallego, A. L. Warshaw, W. R. Brugge, D. G. Forcione, S. P. Thayer, and C. Fernández-del Castillo, “Current Trends in Pancreatic Cystic Neoplasms,” Arch. Surg.144(5), 448–454 (2009).
[CrossRef] [PubMed]

Fichter, G. D.

Fingerle, A. A.

M. Erkan, S. Hausmann, C. W. Michalski, A. A. Fingerle, M. Dobritz, J. Kleeff, and H. Friess, “The role of stroma in pancreatic cancer: diagnostic and therapeutic implications,” Nat. Rev. Gastroenterol. Hepatol.9(8), 454–467 (2012).
[CrossRef] [PubMed]

Fitzmaurice, M.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt.13(2), 024012 (2008).
[CrossRef] [PubMed]

Follen, M.

R. Drezek, M. Guillaud, T. Collier, I. Boiko, A. Malpica, C. Macaulay, M. Follen, and R. Richards-Kortum, “Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture,” J. Biomed. Opt.8(1), 7–16 (2003).
[CrossRef] [PubMed]

Forcione, D. G.

C. R. Ferrone, C. Correa-Gallego, A. L. Warshaw, W. R. Brugge, D. G. Forcione, S. P. Thayer, and C. Fernández-del Castillo, “Current Trends in Pancreatic Cystic Neoplasms,” Arch. Surg.144(5), 448–454 (2009).
[CrossRef] [PubMed]

Friess, H.

M. Erkan, S. Hausmann, C. W. Michalski, A. A. Fingerle, M. Dobritz, J. Kleeff, and H. Friess, “The role of stroma in pancreatic cancer: diagnostic and therapeutic implications,” Nat. Rev. Gastroenterol. Hepatol.9(8), 454–467 (2012).
[CrossRef] [PubMed]

Fukushima, N.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Fulghum, S.

C. Lau, O. Sćepanović, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, “Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy,” J. Biomed. Opt.14(2), 024031 (2009).
[CrossRef] [PubMed]

Furukawa, T.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Goggins, M.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Guillaud, M.

R. Drezek, M. Guillaud, T. Collier, I. Boiko, A. Malpica, C. Macaulay, M. Follen, and R. Richards-Kortum, “Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture,” J. Biomed. Opt.8(1), 7–16 (2003).
[CrossRef] [PubMed]

Haka, A. S.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt.13(2), 024012 (2008).
[CrossRef] [PubMed]

Hamano, T.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Hammel, P.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

Hartman, D. J.

R. K. Bista, S. Uttam, P. Wang, K. Staton, S. Choi, C. J. Bakkenist, D. J. Hartman, R. E. Brand, and Y. Liu, “Quantification of nanoscale nuclear refractive index changes during the cell cycle,” J. Biomed. Opt.16(7), 070503 (2011).
[CrossRef] [PubMed]

Hausmann, S.

M. Erkan, S. Hausmann, C. W. Michalski, A. A. Fingerle, M. Dobritz, J. Kleeff, and H. Friess, “The role of stroma in pancreatic cancer: diagnostic and therapeutic implications,” Nat. Rev. Gastroenterol. Hepatol.9(8), 454–467 (2012).
[CrossRef] [PubMed]

Heidt, D.

M. Chandra, J. Scheiman, D. Heidt, D. Simeone, B. McKenna, and M.-A. Mycek, “Probing pancreatic disease using tissue optical spectroscopy,” J. Biomed. Opt.12(6), 060501 (2007).
[CrossRef] [PubMed]

Hollister, S. J.

Hoogsteden, H. C.

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. C. M. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt.15(1), 017004 (2010).
[CrossRef] [PubMed]

Hruban, R. H.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Ishihara, T.

T. Baba, T. Yamaguchi, T. Ishihara, A. Kobayashi, T. Oshima, N. Sakaue, K. Kato, M. Ebara, and H. Saisho, “Distinguishing benign from malignant intraductal papillary mucinous tumors of the pancreas by imaging techniques,” Pancreas29(3), 212–217 (2004).
[CrossRef] [PubMed]

Itzkan, I.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Kanick, S. C.

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. C. M. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt.15(1), 017004 (2010).
[CrossRef] [PubMed]

Kascáková, S.

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. C. M. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt.15(1), 017004 (2010).
[CrossRef] [PubMed]

Kato, K.

T. Baba, T. Yamaguchi, T. Ishihara, A. Kobayashi, T. Oshima, N. Sakaue, K. Kato, M. Ebara, and H. Saisho, “Distinguishing benign from malignant intraductal papillary mucinous tumors of the pancreas by imaging techniques,” Pancreas29(3), 212–217 (2004).
[CrossRef] [PubMed]

Kato, Y.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Kleeff, J.

M. Erkan, S. Hausmann, C. W. Michalski, A. A. Fingerle, M. Dobritz, J. Kleeff, and H. Friess, “The role of stroma in pancreatic cancer: diagnostic and therapeutic implications,” Nat. Rev. Gastroenterol. Hepatol.9(8), 454–467 (2012).
[CrossRef] [PubMed]

Klimstra, D. S.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Klöppel, G.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Kobayashi, A.

T. Baba, T. Yamaguchi, T. Ishihara, A. Kobayashi, T. Oshima, N. Sakaue, K. Kato, M. Ebara, and H. Saisho, “Distinguishing benign from malignant intraductal papillary mucinous tumors of the pancreas by imaging techniques,” Pancreas29(3), 212–217 (2004).
[CrossRef] [PubMed]

Lau, C.

C. Lau, O. Sćepanović, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, “Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy,” J. Biomed. Opt.14(2), 024031 (2009).
[CrossRef] [PubMed]

Lévy, P.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

Liao, E.

Lima, C.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Liu, Y.

R. K. Bista, S. Uttam, P. Wang, K. Staton, S. Choi, C. J. Bakkenist, D. J. Hartman, R. E. Brand, and Y. Liu, “Quantification of nanoscale nuclear refractive index changes during the cell cycle,” J. Biomed. Opt.16(7), 070503 (2011).
[CrossRef] [PubMed]

Lloyd, W. R.

Longnecker, D. S.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Lüttges, J.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Macaulay, C.

R. Drezek, M. Guillaud, T. Collier, I. Boiko, A. Malpica, C. Macaulay, M. Follen, and R. Richards-Kortum, “Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture,” J. Biomed. Opt.8(1), 7–16 (2003).
[CrossRef] [PubMed]

Maire, F.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

Maitra, A.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Malpica, A.

R. Drezek, M. Guillaud, T. Collier, I. Boiko, A. Malpica, C. Macaulay, M. Follen, and R. Richards-Kortum, “Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture,” J. Biomed. Opt.8(1), 7–16 (2003).
[CrossRef] [PubMed]

Manoharan, R.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

McGee, S.

C. Lau, O. Sćepanović, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, “Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy,” J. Biomed. Opt.14(2), 024031 (2009).
[CrossRef] [PubMed]

McKenna, B.

R. H. Wilson, M. Chandra, L. C. Chen, W. R. Lloyd, J. Scheiman, D. Simeone, J. Purdy, B. McKenna, and M.-A. Mycek, “Photon-tissue interaction model enables quantitative optical analysis of human pancreatic tissues,” Opt. Express18(21), 21612–21621 (2010).
[CrossRef] [PubMed]

M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek, “Spectral areas and ratios classifier algorithm for pancreatic tissue classification using optical spectroscopy,” J. Biomed. Opt.15(1), 010514 (2010).
[CrossRef] [PubMed]

R. H. Wilson, M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek, “Optical spectroscopy detects histological hallmarks of pancreatic cancer,” Opt. Express17(20), 17502–17516 (2009).
[CrossRef] [PubMed]

M. Chandra, J. Scheiman, D. Heidt, D. Simeone, B. McKenna, and M.-A. Mycek, “Probing pancreatic disease using tissue optical spectroscopy,” J. Biomed. Opt.12(6), 060501 (2007).
[CrossRef] [PubMed]

Michalski, C. W.

M. Erkan, S. Hausmann, C. W. Michalski, A. A. Fingerle, M. Dobritz, J. Kleeff, and H. Friess, “The role of stroma in pancreatic cancer: diagnostic and therapeutic implications,” Nat. Rev. Gastroenterol. Hepatol.9(8), 454–467 (2012).
[CrossRef] [PubMed]

Mirkovic, J.

C. Lau, O. Sćepanović, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, “Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy,” J. Biomed. Opt.14(2), 024031 (2009).
[CrossRef] [PubMed]

Mycek, M.-A.

R. H. Wilson and M.-A. Mycek, “Models of light propagation in human tissue applied to cancer diagnostics,” Technol. Cancer Res. Treat.10(2), 121–134 (2011).
[PubMed]

M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek, “Spectral areas and ratios classifier algorithm for pancreatic tissue classification using optical spectroscopy,” J. Biomed. Opt.15(1), 010514 (2010).
[CrossRef] [PubMed]

R. H. Wilson, M. Chandra, L. C. Chen, W. R. Lloyd, J. Scheiman, D. Simeone, J. Purdy, B. McKenna, and M.-A. Mycek, “Photon-tissue interaction model enables quantitative optical analysis of human pancreatic tissues,” Opt. Express18(21), 21612–21621 (2010).
[CrossRef] [PubMed]

R. H. Wilson, M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek, “Optical spectroscopy detects histological hallmarks of pancreatic cancer,” Opt. Express17(20), 17502–17516 (2009).
[CrossRef] [PubMed]

M. Chandra, J. Scheiman, D. Heidt, D. Simeone, B. McKenna, and M.-A. Mycek, “Probing pancreatic disease using tissue optical spectroscopy,” J. Biomed. Opt.12(6), 060501 (2007).
[CrossRef] [PubMed]

M. Chandra, K. Vishwanath, G. D. Fichter, E. Liao, S. J. Hollister, and M.-A. Mycek, “Quantitative molecular sensing in biological tissues: an approach to non-invasive optical characterization,” Opt. Express14(13), 6157–6171 (2006).
[CrossRef] [PubMed]

M.-A. Mycek, K. T. Schomacker, and N. S. Nishioka, “Colonic polyp differentiation using time-resolved autofluorescence spectroscopy,” Gastrointest. Endosc.48(4), 390–394 (1998).
[CrossRef] [PubMed]

Nazemi, J.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt.13(2), 024012 (2008).
[CrossRef] [PubMed]

Nishioka, N. S.

M.-A. Mycek, K. T. Schomacker, and N. S. Nishioka, “Colonic polyp differentiation using time-resolved autofluorescence spectroscopy,” Gastrointest. Endosc.48(4), 390–394 (1998).
[CrossRef] [PubMed]

Nusrat, A.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

O’toole, D.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

Offerhaus, G. J.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Oshima, T.

T. Baba, T. Yamaguchi, T. Ishihara, A. Kobayashi, T. Oshima, N. Sakaue, K. Kato, M. Ebara, and H. Saisho, “Distinguishing benign from malignant intraductal papillary mucinous tumors of the pancreas by imaging techniques,” Pancreas29(3), 212–217 (2004).
[CrossRef] [PubMed]

Palazzo, L.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

Palmer, G. M.

V. T.-C. Chang, P. S. Cartwright, S. M. Bean, G. M. Palmer, R. C. Bentley, and N. Ramanujam, “Quantitative physiology of the precancerous cervix in vivo through optical spectroscopy,” Neoplasia11(4), 325–332 (2009).
[PubMed]

Perelman, L. T.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Ponsot, P.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

Purdy, J.

Ramanujam, N.

V. T.-C. Chang, P. S. Cartwright, S. M. Bean, G. M. Palmer, R. C. Bentley, and N. Ramanujam, “Quantitative physiology of the precancerous cervix in vivo through optical spectroscopy,” Neoplasia11(4), 325–332 (2009).
[PubMed]

Richards-Kortum, R.

R. Drezek, M. Guillaud, T. Collier, I. Boiko, A. Malpica, C. Macaulay, M. Follen, and R. Richards-Kortum, “Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture,” J. Biomed. Opt.8(1), 7–16 (2003).
[CrossRef] [PubMed]

Ruszniewski, P.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

Saisho, H.

T. Baba, T. Yamaguchi, T. Ishihara, A. Kobayashi, T. Oshima, N. Sakaue, K. Kato, M. Ebara, and H. Saisho, “Distinguishing benign from malignant intraductal papillary mucinous tumors of the pancreas by imaging techniques,” Pancreas29(3), 212–217 (2004).
[CrossRef] [PubMed]

Sakaue, N.

T. Baba, T. Yamaguchi, T. Ishihara, A. Kobayashi, T. Oshima, N. Sakaue, K. Kato, M. Ebara, and H. Saisho, “Distinguishing benign from malignant intraductal papillary mucinous tumors of the pancreas by imaging techniques,” Pancreas29(3), 212–217 (2004).
[CrossRef] [PubMed]

Scepanovic, O.

C. Lau, O. Sćepanović, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, “Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy,” J. Biomed. Opt.14(2), 024031 (2009).
[CrossRef] [PubMed]

Scheiman, J.

M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek, “Spectral areas and ratios classifier algorithm for pancreatic tissue classification using optical spectroscopy,” J. Biomed. Opt.15(1), 010514 (2010).
[CrossRef] [PubMed]

R. H. Wilson, M. Chandra, L. C. Chen, W. R. Lloyd, J. Scheiman, D. Simeone, J. Purdy, B. McKenna, and M.-A. Mycek, “Photon-tissue interaction model enables quantitative optical analysis of human pancreatic tissues,” Opt. Express18(21), 21612–21621 (2010).
[CrossRef] [PubMed]

R. H. Wilson, M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek, “Optical spectroscopy detects histological hallmarks of pancreatic cancer,” Opt. Express17(20), 17502–17516 (2009).
[CrossRef] [PubMed]

M. Chandra, J. Scheiman, D. Heidt, D. Simeone, B. McKenna, and M.-A. Mycek, “Probing pancreatic disease using tissue optical spectroscopy,” J. Biomed. Opt.12(6), 060501 (2007).
[CrossRef] [PubMed]

Schomacker, K. T.

M.-A. Mycek, K. T. Schomacker, and N. S. Nishioka, “Colonic polyp differentiation using time-resolved autofluorescence spectroscopy,” Gastrointest. Endosc.48(4), 390–394 (1998).
[CrossRef] [PubMed]

Seiler, M.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Shenk, R.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt.13(2), 024012 (2008).
[CrossRef] [PubMed]

Shields, S.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Shimizu, M.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Simeone, D.

R. H. Wilson, M. Chandra, L. C. Chen, W. R. Lloyd, J. Scheiman, D. Simeone, J. Purdy, B. McKenna, and M.-A. Mycek, “Photon-tissue interaction model enables quantitative optical analysis of human pancreatic tissues,” Opt. Express18(21), 21612–21621 (2010).
[CrossRef] [PubMed]

M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek, “Spectral areas and ratios classifier algorithm for pancreatic tissue classification using optical spectroscopy,” J. Biomed. Opt.15(1), 010514 (2010).
[CrossRef] [PubMed]

R. H. Wilson, M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek, “Optical spectroscopy detects histological hallmarks of pancreatic cancer,” Opt. Express17(20), 17502–17516 (2009).
[CrossRef] [PubMed]

M. Chandra, J. Scheiman, D. Heidt, D. Simeone, B. McKenna, and M.-A. Mycek, “Probing pancreatic disease using tissue optical spectroscopy,” J. Biomed. Opt.12(6), 060501 (2007).
[CrossRef] [PubMed]

Staton, K.

R. K. Bista, S. Uttam, P. Wang, K. Staton, S. Choi, C. J. Bakkenist, D. J. Hartman, R. E. Brand, and Y. Liu, “Quantification of nanoscale nuclear refractive index changes during the cell cycle,” J. Biomed. Opt.16(7), 070503 (2011).
[CrossRef] [PubMed]

Sterenborg, H. J. C. M.

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. C. M. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt.15(1), 017004 (2010).
[CrossRef] [PubMed]

A. Amelink, H. J. C. M. Sterenborg, M. P. L. Bard, and S. A. Burgers, “In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy,” Opt. Lett.29(10), 1087–1089 (2004).
[CrossRef] [PubMed]

Takaori, K.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Tamhane, A.

M. A. Eloubeidi and A. Tamhane, “EUS-guided FNA of solid pancreatic masses: a learning curve with 300 consecutive procedures,” Gastrointest. Endosc.61(6), 700–708 (2005).
[CrossRef] [PubMed]

Thayer, S. P.

C. R. Ferrone, C. Correa-Gallego, A. L. Warshaw, W. R. Brugge, D. G. Forcione, S. P. Thayer, and C. Fernández-del Castillo, “Current Trends in Pancreatic Cystic Neoplasms,” Arch. Surg.144(5), 448–454 (2009).
[CrossRef] [PubMed]

Tunnell, J.

C. Lau, O. Sćepanović, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, “Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy,” J. Biomed. Opt.14(2), 024031 (2009).
[CrossRef] [PubMed]

Uttam, S.

R. K. Bista, S. Uttam, P. Wang, K. Staton, S. Choi, C. J. Bakkenist, D. J. Hartman, R. E. Brand, and Y. Liu, “Quantification of nanoscale nuclear refractive index changes during the cell cycle,” J. Biomed. Opt.16(7), 070503 (2011).
[CrossRef] [PubMed]

Van Dam, J.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

van der Leest, C.

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. C. M. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt.15(1), 017004 (2010).
[CrossRef] [PubMed]

Vishwanath, K.

Volynskaya, Z.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt.13(2), 024012 (2008).
[CrossRef] [PubMed]

Wallace, M.

C. Lau, O. Sćepanović, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, “Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy,” J. Biomed. Opt.14(2), 024031 (2009).
[CrossRef] [PubMed]

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Wang, N.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt.13(2), 024012 (2008).
[CrossRef] [PubMed]

Wang, P.

R. K. Bista, S. Uttam, P. Wang, K. Staton, S. Choi, C. J. Bakkenist, D. J. Hartman, R. E. Brand, and Y. Liu, “Quantification of nanoscale nuclear refractive index changes during the cell cycle,” J. Biomed. Opt.16(7), 070503 (2011).
[CrossRef] [PubMed]

Warshaw, A. L.

C. R. Ferrone, C. Correa-Gallego, A. L. Warshaw, W. R. Brugge, D. G. Forcione, S. P. Thayer, and C. Fernández-del Castillo, “Current Trends in Pancreatic Cystic Neoplasms,” Arch. Surg.144(5), 448–454 (2009).
[CrossRef] [PubMed]

Wilson, R. H.

Yamaguchi, T.

T. Baba, T. Yamaguchi, T. Ishihara, A. Kobayashi, T. Oshima, N. Sakaue, K. Kato, M. Ebara, and H. Saisho, “Distinguishing benign from malignant intraductal papillary mucinous tumors of the pancreas by imaging techniques,” Pancreas29(3), 212–217 (2004).
[CrossRef] [PubMed]

Yonezawa, S.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Yu, C. C.

C. Lau, O. Sćepanović, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, “Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy,” J. Biomed. Opt.14(2), 024031 (2009).
[CrossRef] [PubMed]

Zonios, G.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Am. J. Surg. Pathol.

R. H. Hruban, K. Takaori, D. S. Klimstra, N. V. Adsay, J. Albores-Saavedra, A. V. Biankin, S. A. Biankin, C. Compton, N. Fukushima, T. Furukawa, M. Goggins, Y. Kato, G. Klöppel, D. S. Longnecker, J. Lüttges, A. Maitra, G. J. Offerhaus, M. Shimizu, and S. Yonezawa, “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” Am. J. Surg. Pathol.28(8), 977–987 (2004).
[CrossRef] [PubMed]

Arch. Surg.

C. R. Ferrone, C. Correa-Gallego, A. L. Warshaw, W. R. Brugge, D. G. Forcione, S. P. Thayer, and C. Fernández-del Castillo, “Current Trends in Pancreatic Cystic Neoplasms,” Arch. Surg.144(5), 448–454 (2009).
[CrossRef] [PubMed]

Gastrointest. Endosc.

F. Maire, A. Couvelard, P. Hammel, P. Ponsot, L. Palazzo, A. Aubert, C. Degott, A. Dancour, M. Felce-Dachez, D. O’toole, P. Lévy, and P. Ruszniewski, “Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis,” Gastrointest. Endosc.58(5), 701–706 (2003).
[CrossRef] [PubMed]

M. A. Eloubeidi and A. Tamhane, “EUS-guided FNA of solid pancreatic masses: a learning curve with 300 consecutive procedures,” Gastrointest. Endosc.61(6), 700–708 (2005).
[CrossRef] [PubMed]

M.-A. Mycek, K. T. Schomacker, and N. S. Nishioka, “Colonic polyp differentiation using time-resolved autofluorescence spectroscopy,” Gastrointest. Endosc.48(4), 390–394 (1998).
[CrossRef] [PubMed]

J. Biomed. Opt.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt.13(2), 024012 (2008).
[CrossRef] [PubMed]

R. K. Bista, S. Uttam, P. Wang, K. Staton, S. Choi, C. J. Bakkenist, D. J. Hartman, R. E. Brand, and Y. Liu, “Quantification of nanoscale nuclear refractive index changes during the cell cycle,” J. Biomed. Opt.16(7), 070503 (2011).
[CrossRef] [PubMed]

C. Lau, O. Sćepanović, J. Mirkovic, S. McGee, C. C. Yu, S. Fulghum, M. Wallace, J. Tunnell, K. Bechtel, and M. Feld, “Re-evaluation of model-based light-scattering spectroscopy for tissue spectroscopy,” J. Biomed. Opt.14(2), 024031 (2009).
[CrossRef] [PubMed]

M. Chandra, J. Scheiman, D. Heidt, D. Simeone, B. McKenna, and M.-A. Mycek, “Probing pancreatic disease using tissue optical spectroscopy,” J. Biomed. Opt.12(6), 060501 (2007).
[CrossRef] [PubMed]

M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek, “Spectral areas and ratios classifier algorithm for pancreatic tissue classification using optical spectroscopy,” J. Biomed. Opt.15(1), 010514 (2010).
[CrossRef] [PubMed]

R. Drezek, M. Guillaud, T. Collier, I. Boiko, A. Malpica, C. Macaulay, M. Follen, and R. Richards-Kortum, “Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture,” J. Biomed. Opt.8(1), 7–16 (2003).
[CrossRef] [PubMed]

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. C. M. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt.15(1), 017004 (2010).
[CrossRef] [PubMed]

Nat. Rev. Gastroenterol. Hepatol.

M. Erkan, S. Hausmann, C. W. Michalski, A. A. Fingerle, M. Dobritz, J. Kleeff, and H. Friess, “The role of stroma in pancreatic cancer: diagnostic and therapeutic implications,” Nat. Rev. Gastroenterol. Hepatol.9(8), 454–467 (2012).
[CrossRef] [PubMed]

Neoplasia

V. T.-C. Chang, P. S. Cartwright, S. M. Bean, G. M. Palmer, R. C. Bentley, and N. Ramanujam, “Quantitative physiology of the precancerous cervix in vivo through optical spectroscopy,” Neoplasia11(4), 325–332 (2009).
[PubMed]

Opt. Express

Opt. Lett.

Pancreas

T. Baba, T. Yamaguchi, T. Ishihara, A. Kobayashi, T. Oshima, N. Sakaue, K. Kato, M. Ebara, and H. Saisho, “Distinguishing benign from malignant intraductal papillary mucinous tumors of the pancreas by imaging techniques,” Pancreas29(3), 212–217 (2004).
[CrossRef] [PubMed]

Phys. Rev. Lett.

L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
[CrossRef]

Technol. Cancer Res. Treat.

R. H. Wilson and M.-A. Mycek, “Models of light propagation in human tissue applied to cancer diagnostics,” Technol. Cancer Res. Treat.10(2), 121–134 (2011).
[PubMed]

Other

Cancer Facts & Figures 2013” (American Cancer Society, 2013), retrieved www.cancer.org .

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Figures (3)

Fig. 1
Fig. 1

Representative histological images of (A) normal pancreatic ductal tissue (BPC: benign pancreatic cell), (B) IPMN (MPC: malignant pancreatic cell with enlarged nuclei), and (C) pancreatic adenocarcinoma (AC with enlarged nuclei). The nuclei and stroma have been stained purple (hematoxylin stain) and pink (eosin stain), respectively. Note that IPMN and AC tissues have similar biophysical features, including nuclear enlargement and abundant collagen surrounding cells, relative to normal tissues. These features can be analyzed by quantitative multimodal optical spectroscopy.

Fig. 2
Fig. 2

Quantitative analysis of measured reflectance spectra can distinguish IPMN and AC from normal pancreas. (A) Mean of normalized reflectance spectra obtained from human pancreatic normal tissues, IPMN with moderate dysplasia, and AC. (B) Wavelength-dependent standard error bars of mean measured spectra for each tissue type. (C) Representative DF-PTI model fit for IPMN reflectance.

Fig. 3
Fig. 3

Quantitative analysis of measured fluorescence spectra can distinguish IPMN and AC from normal pancreas. (A) Mean of normalized fluorescence spectra obtained from human pancreatic normal tissues, IPMN with moderate dysplasia, and AC. (B) Wavelength-dependent standard error of mean spectra for each tissue type. (C) Representative PTI model fit for IPMN intrinsic fluorescence.

Tables (3)

Tables Icon

Table 1 Numbers of patients and analyzed tissue sites for each tissue type

Tables Icon

Table 2 Ranges of all the varied tissue parameters in the DF-PTI reflectance model

Tables Icon

Table 3 Extracted parameters related to tissue scattering for each tissue type (Mean ± Std. Error)

Metrics