Abstract

The Optics in the Life Sciences conference sponsored by the Optical Society of America was held in Waikoloa Beach, HI on April 14 – 18, 2013. Papers were presented in the areas of Bio-Optics: Design & Application, Novel Techniques in Microscopy, Optical Molecular Probes, Imaging & Drug Delivery, and Optical Trapping Applications. A focal point of the meeting was a special symposium entitled “Photons Across Medicine”, organized by Adam Wax, Duke University, highlighting activities of joint interest between the Optical Society of America (OSA) and the Society for Nuclear Medicine and Molecular Imaging (SNMMI). This paper is a synopsis of the presentations made at this joint symposium. Central to the special symposium presentations was the fact that the optical and nuclear imaging communities share common interests and challenges. These are highlighted in this article. Also discussed was the fact that the nuclear technologies in imaging have found their way into general clinical utility, a feat that has yet to be achieved by optical methods. Because of the common ground shared by the two technologies, coordination between the two societies should be planned.

© 2013 Optical Society of America

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2013 (3)

S. C. Ghosh, P. Ghosh, N. Wilganowski, H. Robinson, M. A. Hall, G. Dickinson, K. L. Pinkston, B. R. Harvey, E. M. Sevick-Muraca, A. Azhdarinia, “Multimodal chelation platform for near-infrared fluorescence/nuclear imaging,” J. Med. Chem. 56(2), 406–416 (2013).
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[CrossRef] [PubMed]

2012 (3)

E. M. Sevick-Muraca, “Translation of near-infrared fluorescence imaging technologies: emerging clinical applications,” Annu. Rev. Med. 63(1), 217–231 (2012).
[CrossRef] [PubMed]

A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol. 14(3), 261–276 (2012).
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[CrossRef] [PubMed]

2011 (8)

M. Yokouchi, M. Terahara, S. Nagano, Y. Arishima, M. Zemmyo, T. Yoshioka, A. Tanimoto, S. Komiya, “Clinical implications of determination of safe surgical margins by using a combination of CT and 18FDG-positron emission tomography in soft tissue sarcoma,” BMC Musculoskelet. Disord. 12(1), 166 (2011).
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G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[CrossRef] [PubMed]

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[CrossRef] [PubMed]

B. E. Schaafsma, J. S. Mieog, M. Hutteman, J. R. van der Vorst, P. J. Kuppen, C. W. Löwik, J. V. Frangioni, C. J. van de Velde, A. L. Vahrmeijer, “The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery,” J. Surg. Oncol. 104(3), 323–332 (2011).
[CrossRef] [PubMed]

B. C. Drolet, N. M. Lorenzi, “Translational research: understanding the continuum from bench to bedside,” Transl. Res. 157(1), 1–5 (2011).
[CrossRef] [PubMed]

C. Q. Li, Y. F. Yang, G. S. Mitchell, S. R. Cherry, “Simultaneous PET and multispectral 3-dimensional fluorescence optical tomography imaging system,” J. Nucl. Med. 52(8), 1268–1275 (2011).
[CrossRef] [PubMed]

G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Q. Li, S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Phil. Trans. Roy. Soc. A. 369(1955), 4605–4619 (2011).

Y. Xu, H. Liu, Z. Cheng, “Harnessing the power of radionuclides for optical imaging: Cerenkov luminescence imaging,” J. Nucl. Med. 52(12), 2009–2018 (2011).
[CrossRef] [PubMed]

2010 (4)

L. J. Cao, J. Peter, “Bayesian reconstruction strategy of fluorescence-mediated tomography using an integrated SPECT-CT-OT system,” Phys. Med. Biol. 55(9), 2693–2708 (2010).
[CrossRef] [PubMed]

M. V. Marshall, J. C. Rasmussen, I.-C. Tan, M. B. Aldrich, K. E. Adams, X. Wang, C. E. Fife, E. A. Maus, L. A. Smith, E. M. Sevick-Muraca, “Near-infrared fluorescence imaging in humans with indocyanine green: a review and update,” Open Surg Oncol J 2(2), 12–25 (2010).
[CrossRef] [PubMed]

B. T. Lee, M. Hutteman, S. Gioux, A. Stockdale, S. J. Lin, L. H. Ngo, J. V. Frangioni, “The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction,” Plast. Reconstr. Surg. 126(5), 1472–1481 (2010).
[CrossRef] [PubMed]

J. Kuil, A. H. Velders, F. W. van Leeuwen, “Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label,” Bioconjug. Chem. 21(10), 1709–1719 (2010).
[CrossRef] [PubMed]

2009 (2)

T. J. Ruers, B. Wiering, J. R. van der Sijp, R. M. Roumen, K. P. de Jong, E. F. Comans, J. Pruim, H. M. Dekker, P. F. Krabbe, W. J. Oyen, “Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study,” J. Nucl. Med. 50(7), 1036–1041 (2009).
[CrossRef] [PubMed]

R. Alford, H. M. Simpson, J. Duberman, G. C. Hill, M. Ogawa, C. Regino, H. Kobayashi, P. L. Choyke, “Toxicity of organic fluorophores used in molecular imaging: literature review,” Mol. Imaging 8(6), 341–354 (2009).
[PubMed]

2008 (7)

E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
[CrossRef] [PubMed]

A. M. Wu, “Antibodies and antimatter: the resurgence of immuno-PET,” J. Nucl. Med. 50(1), 2–5 (2008).
[CrossRef] [PubMed]

D. Dougherty, P. H. Conway, “The “3T’s” road map to transform US health care: the “how” of high-quality care,” JAMA 299(19), 2319–2321 (2008).
[CrossRef] [PubMed]

H. F. VanBrocklin, “Radiopharmaceuticals for drug development: United States regulatory perspective,” Current Radiopharmaceuticals 1(1), 2–6 (2008).
[CrossRef]

A. Douraghy, F. R. Rannou, R. W. Silverman, A. F. Chatziioannou, “FPGA electronics for OPET: a dual modality optical and positron emission tomography,” IEEE Trans. Nucl. Sci. 55(5), 2541–2545 (2008).
[CrossRef]

J. Culver, W. Akers, S. Achilefu, “Multimodality molecular imaging with combined optical and SPECT/PET modalities,” J. Nucl. Med. 49(2), 169–172 (2008).
[CrossRef] [PubMed]

T. K. Lewellen, “Recent developments in PET detector technology,” Phys. Med. Biol. 53(17), R287–R317 (2008).
[CrossRef] [PubMed]

2007 (2)

E. A. Zerhouni, “Translational research: moving discovery to practice,” Clin. Pharmacol. Ther. 81(1), 126–128 (2007).
[CrossRef] [PubMed]

M. B. Rosenthal, B. E. Landon, K. Howitt, H. R. Song, A. M. Epstein, “Climbing the pay-for performance learning curve: where are the early adopters now?” Health Aff. 26(6), 1674–1682 (2007).
[CrossRef]

2006 (2)

W. McLaughlin, D. Vizard, “Kodak in vivo imaging system: precise co-registration of molecular imaging with anatomical x-ray imaging,” Nat. Methods 5, 26–28 (2006).

A. D. Nunn, “The cost of developing imaging agents for routine clinical use,” Invest. Radiol. 41(3), 206–212 (2006).
[CrossRef] [PubMed]

2005 (2)

S. R. Meikle, P. Kench, M. Kassiou, R. B. Banati, “Small animal SPECT and its place in the matrix of molecular imaging technologies,” Phys. Med. Biol. 50(22), R45–R61 (2005).
[CrossRef] [PubMed]

R. E. Weiner, M. L. Thakur, “Radiolabeled peptides in oncology: role in diagnosis and treatment,” BioDrugs 19(3), 145–163 (2005).
[CrossRef] [PubMed]

2003 (1)

S. R. Tunis, D. B. Stryer, C. M. Clancy, “Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy,” J. Am. Med. Assoc. 290(12), 1624–1632 (2003).
[CrossRef] [PubMed]

2002 (1)

A. Barros, M. A. Cardoso, P. Y. Sheng, P. A. Costa, C. Pelizon, “Radioguided localisation of non-palpable breast lesions and simultaneous sentinel lymph node mapping,” Eur. J. Nucl. Med. Mol. Imaging 29(12), 1561–1565 (2002).
[CrossRef] [PubMed]

2000 (1)

S. Achilefu, R. B. Dorshow, J. E. Bugaj, R. Rajagopalan, “Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging,” Invest. Radiol. 35(8), 479–485 (2000).
[CrossRef] [PubMed]

1990 (1)

A. J. Fischman, R. H. Rubin, J. A. White, E. Locke, R. A. Wilkinson, M. Nedelman, R. J. Callahan, B. A. Khaw, H. W. Strauss, “Localization of Fc and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation,” J. Nucl. Med. 31(7), 1199–1205 (1990).
[PubMed]

1974 (1)

S. Wolf, “Editorial: The real gap between bench and bedside,” N. Engl. J. Med. 290(14), 802–803 (1974).
[CrossRef] [PubMed]

Achilefu, S.

J. Culver, W. Akers, S. Achilefu, “Multimodality molecular imaging with combined optical and SPECT/PET modalities,” J. Nucl. Med. 49(2), 169–172 (2008).
[CrossRef] [PubMed]

S. Achilefu, R. B. Dorshow, J. E. Bugaj, R. Rajagopalan, “Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging,” Invest. Radiol. 35(8), 479–485 (2000).
[CrossRef] [PubMed]

Adams, K. E.

M. V. Marshall, J. C. Rasmussen, I.-C. Tan, M. B. Aldrich, K. E. Adams, X. Wang, C. E. Fife, E. A. Maus, L. A. Smith, E. M. Sevick-Muraca, “Near-infrared fluorescence imaging in humans with indocyanine green: a review and update,” Open Surg Oncol J 2(2), 12–25 (2010).
[CrossRef] [PubMed]

E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
[CrossRef] [PubMed]

Akers, W.

J. Culver, W. Akers, S. Achilefu, “Multimodality molecular imaging with combined optical and SPECT/PET modalities,” J. Nucl. Med. 49(2), 169–172 (2008).
[CrossRef] [PubMed]

Aldrich, M. B.

M. V. Marshall, J. C. Rasmussen, I.-C. Tan, M. B. Aldrich, K. E. Adams, X. Wang, C. E. Fife, E. A. Maus, L. A. Smith, E. M. Sevick-Muraca, “Near-infrared fluorescence imaging in humans with indocyanine green: a review and update,” Open Surg Oncol J 2(2), 12–25 (2010).
[CrossRef] [PubMed]

Alford, R.

R. Alford, H. M. Simpson, J. Duberman, G. C. Hill, M. Ogawa, C. Regino, H. Kobayashi, P. L. Choyke, “Toxicity of organic fluorophores used in molecular imaging: literature review,” Mol. Imaging 8(6), 341–354 (2009).
[PubMed]

Arce, P.

Arishima, Y.

M. Yokouchi, M. Terahara, S. Nagano, Y. Arishima, M. Zemmyo, T. Yoshioka, A. Tanimoto, S. Komiya, “Clinical implications of determination of safe surgical margins by using a combination of CT and 18FDG-positron emission tomography in soft tissue sarcoma,” BMC Musculoskelet. Disord. 12(1), 166 (2011).
[CrossRef] [PubMed]

Arts, H. J.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[CrossRef] [PubMed]

Azhdarinia, A.

S. C. Ghosh, P. Ghosh, N. Wilganowski, H. Robinson, M. A. Hall, G. Dickinson, K. L. Pinkston, B. R. Harvey, E. M. Sevick-Muraca, A. Azhdarinia, “Multimodal chelation platform for near-infrared fluorescence/nuclear imaging,” J. Med. Chem. 56(2), 406–416 (2013).
[CrossRef] [PubMed]

A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol. 14(3), 261–276 (2012).
[CrossRef] [PubMed]

Banati, R. B.

S. R. Meikle, P. Kench, M. Kassiou, R. B. Banati, “Small animal SPECT and its place in the matrix of molecular imaging technologies,” Phys. Med. Biol. 50(22), R45–R61 (2005).
[CrossRef] [PubMed]

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A. Barros, M. A. Cardoso, P. Y. Sheng, P. A. Costa, C. Pelizon, “Radioguided localisation of non-palpable breast lesions and simultaneous sentinel lymph node mapping,” Eur. J. Nucl. Med. Mol. Imaging 29(12), 1561–1565 (2002).
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G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[CrossRef] [PubMed]

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E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
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G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Q. Li, S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Phil. Trans. Roy. Soc. A. 369(1955), 4605–4619 (2011).

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S. Achilefu, R. B. Dorshow, J. E. Bugaj, R. Rajagopalan, “Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging,” Invest. Radiol. 35(8), 479–485 (2000).
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A. J. Fischman, R. H. Rubin, J. A. White, E. Locke, R. A. Wilkinson, M. Nedelman, R. J. Callahan, B. A. Khaw, H. W. Strauss, “Localization of Fc and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation,” J. Nucl. Med. 31(7), 1199–1205 (1990).
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L. J. Cao, J. Peter, “Bayesian reconstruction strategy of fluorescence-mediated tomography using an integrated SPECT-CT-OT system,” Phys. Med. Biol. 55(9), 2693–2708 (2010).
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A. Barros, M. A. Cardoso, P. Y. Sheng, P. A. Costa, C. Pelizon, “Radioguided localisation of non-palpable breast lesions and simultaneous sentinel lymph node mapping,” Eur. J. Nucl. Med. Mol. Imaging 29(12), 1561–1565 (2002).
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A. Douraghy, F. R. Rannou, R. W. Silverman, A. F. Chatziioannou, “FPGA electronics for OPET: a dual modality optical and positron emission tomography,” IEEE Trans. Nucl. Sci. 55(5), 2541–2545 (2008).
[CrossRef]

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Y. Xu, H. Liu, Z. Cheng, “Harnessing the power of radionuclides for optical imaging: Cerenkov luminescence imaging,” J. Nucl. Med. 52(12), 2009–2018 (2011).
[CrossRef] [PubMed]

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C. Q. Li, Y. F. Yang, G. S. Mitchell, S. R. Cherry, “Simultaneous PET and multispectral 3-dimensional fluorescence optical tomography imaging system,” J. Nucl. Med. 52(8), 1268–1275 (2011).
[CrossRef] [PubMed]

G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Q. Li, S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Phil. Trans. Roy. Soc. A. 369(1955), 4605–4619 (2011).

Chiang, S. B.

E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
[CrossRef] [PubMed]

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R. Alford, H. M. Simpson, J. Duberman, G. C. Hill, M. Ogawa, C. Regino, H. Kobayashi, P. L. Choyke, “Toxicity of organic fluorophores used in molecular imaging: literature review,” Mol. Imaging 8(6), 341–354 (2009).
[PubMed]

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T. J. Ruers, B. Wiering, J. R. van der Sijp, R. M. Roumen, K. P. de Jong, E. F. Comans, J. Pruim, H. M. Dekker, P. F. Krabbe, W. J. Oyen, “Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study,” J. Nucl. Med. 50(7), 1036–1041 (2009).
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D. Dougherty, P. H. Conway, “The “3T’s” road map to transform US health care: the “how” of high-quality care,” JAMA 299(19), 2319–2321 (2008).
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J. C. Rasmussen, S. Kwon, E. M. Sevick-Muraca, J. N. Cormier, “The role of lymphatics in cancer as assessed by near-infrared fluorescence imaging,” Ann. Biomed. Eng. 40(2), 408–421 (2012).
[CrossRef] [PubMed]

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A. Barros, M. A. Cardoso, P. Y. Sheng, P. A. Costa, C. Pelizon, “Radioguided localisation of non-palpable breast lesions and simultaneous sentinel lymph node mapping,” Eur. J. Nucl. Med. Mol. Imaging 29(12), 1561–1565 (2002).
[CrossRef] [PubMed]

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G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
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G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[CrossRef] [PubMed]

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T. J. Ruers, B. Wiering, J. R. van der Sijp, R. M. Roumen, K. P. de Jong, E. F. Comans, J. Pruim, H. M. Dekker, P. F. Krabbe, W. J. Oyen, “Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study,” J. Nucl. Med. 50(7), 1036–1041 (2009).
[CrossRef] [PubMed]

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T. J. Ruers, B. Wiering, J. R. van der Sijp, R. M. Roumen, K. P. de Jong, E. F. Comans, J. Pruim, H. M. Dekker, P. F. Krabbe, W. J. Oyen, “Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study,” J. Nucl. Med. 50(7), 1036–1041 (2009).
[CrossRef] [PubMed]

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S. C. Ghosh, P. Ghosh, N. Wilganowski, H. Robinson, M. A. Hall, G. Dickinson, K. L. Pinkston, B. R. Harvey, E. M. Sevick-Muraca, A. Azhdarinia, “Multimodal chelation platform for near-infrared fluorescence/nuclear imaging,” J. Med. Chem. 56(2), 406–416 (2013).
[CrossRef] [PubMed]

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S. Achilefu, R. B. Dorshow, J. E. Bugaj, R. Rajagopalan, “Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging,” Invest. Radiol. 35(8), 479–485 (2000).
[CrossRef] [PubMed]

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D. Dougherty, P. H. Conway, “The “3T’s” road map to transform US health care: the “how” of high-quality care,” JAMA 299(19), 2319–2321 (2008).
[CrossRef] [PubMed]

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A. Douraghy, F. R. Rannou, R. W. Silverman, A. F. Chatziioannou, “FPGA electronics for OPET: a dual modality optical and positron emission tomography,” IEEE Trans. Nucl. Sci. 55(5), 2541–2545 (2008).
[CrossRef]

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B. C. Drolet, N. M. Lorenzi, “Translational research: understanding the continuum from bench to bedside,” Transl. Res. 157(1), 1–5 (2011).
[CrossRef] [PubMed]

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R. Alford, H. M. Simpson, J. Duberman, G. C. Hill, M. Ogawa, C. Regino, H. Kobayashi, P. L. Choyke, “Toxicity of organic fluorophores used in molecular imaging: literature review,” Mol. Imaging 8(6), 341–354 (2009).
[PubMed]

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E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
[CrossRef] [PubMed]

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M. B. Rosenthal, B. E. Landon, K. Howitt, H. R. Song, A. M. Epstein, “Climbing the pay-for performance learning curve: where are the early adopters now?” Health Aff. 26(6), 1674–1682 (2007).
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M. V. Marshall, J. C. Rasmussen, I.-C. Tan, M. B. Aldrich, K. E. Adams, X. Wang, C. E. Fife, E. A. Maus, L. A. Smith, E. M. Sevick-Muraca, “Near-infrared fluorescence imaging in humans with indocyanine green: a review and update,” Open Surg Oncol J 2(2), 12–25 (2010).
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[PubMed]

Fisher, R. E.

E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
[CrossRef] [PubMed]

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B. E. Schaafsma, J. S. Mieog, M. Hutteman, J. R. van der Vorst, P. J. Kuppen, C. W. Löwik, J. V. Frangioni, C. J. van de Velde, A. L. Vahrmeijer, “The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery,” J. Surg. Oncol. 104(3), 323–332 (2011).
[CrossRef] [PubMed]

B. T. Lee, M. Hutteman, S. Gioux, A. Stockdale, S. J. Lin, L. H. Ngo, J. V. Frangioni, “The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction,” Plast. Reconstr. Surg. 126(5), 1472–1481 (2010).
[CrossRef] [PubMed]

Ghosh, P.

S. C. Ghosh, P. Ghosh, N. Wilganowski, H. Robinson, M. A. Hall, G. Dickinson, K. L. Pinkston, B. R. Harvey, E. M. Sevick-Muraca, A. Azhdarinia, “Multimodal chelation platform for near-infrared fluorescence/nuclear imaging,” J. Med. Chem. 56(2), 406–416 (2013).
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A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol. 14(3), 261–276 (2012).
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A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol. 14(3), 261–276 (2012).
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Ghosh, S. C.

S. C. Ghosh, P. Ghosh, N. Wilganowski, H. Robinson, M. A. Hall, G. Dickinson, K. L. Pinkston, B. R. Harvey, E. M. Sevick-Muraca, A. Azhdarinia, “Multimodal chelation platform for near-infrared fluorescence/nuclear imaging,” J. Med. Chem. 56(2), 406–416 (2013).
[CrossRef] [PubMed]

Gill, R. K.

G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Q. Li, S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Phil. Trans. Roy. Soc. A. 369(1955), 4605–4619 (2011).

Gioux, S.

B. T. Lee, M. Hutteman, S. Gioux, A. Stockdale, S. J. Lin, L. H. Ngo, J. V. Frangioni, “The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction,” Plast. Reconstr. Surg. 126(5), 1472–1481 (2010).
[CrossRef] [PubMed]

Glaser, A. K.

Gurtner, G. C.

G. C. Gurtner, G. E. Jones, P. C. Neligan, M. I. Newman, B. T. Phillips, J. M. Sacks, M. R. Zenn, “Intraoperative laser angiography using the SPY system: review of the literature and recommendations for use,” Ann. Surg. Innov. Res. 7(1), 1750–1764 (2013).
[CrossRef] [PubMed]

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S. C. Ghosh, P. Ghosh, N. Wilganowski, H. Robinson, M. A. Hall, G. Dickinson, K. L. Pinkston, B. R. Harvey, E. M. Sevick-Muraca, A. Azhdarinia, “Multimodal chelation platform for near-infrared fluorescence/nuclear imaging,” J. Med. Chem. 56(2), 406–416 (2013).
[CrossRef] [PubMed]

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G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[CrossRef] [PubMed]

Harvey, B. R.

S. C. Ghosh, P. Ghosh, N. Wilganowski, H. Robinson, M. A. Hall, G. Dickinson, K. L. Pinkston, B. R. Harvey, E. M. Sevick-Muraca, A. Azhdarinia, “Multimodal chelation platform for near-infrared fluorescence/nuclear imaging,” J. Med. Chem. 56(2), 406–416 (2013).
[CrossRef] [PubMed]

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R. Alford, H. M. Simpson, J. Duberman, G. C. Hill, M. Ogawa, C. Regino, H. Kobayashi, P. L. Choyke, “Toxicity of organic fluorophores used in molecular imaging: literature review,” Mol. Imaging 8(6), 341–354 (2009).
[PubMed]

Houston, J. P.

E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
[CrossRef] [PubMed]

Howitt, K.

M. B. Rosenthal, B. E. Landon, K. Howitt, H. R. Song, A. M. Epstein, “Climbing the pay-for performance learning curve: where are the early adopters now?” Health Aff. 26(6), 1674–1682 (2007).
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B. E. Schaafsma, J. S. Mieog, M. Hutteman, J. R. van der Vorst, P. J. Kuppen, C. W. Löwik, J. V. Frangioni, C. J. van de Velde, A. L. Vahrmeijer, “The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery,” J. Surg. Oncol. 104(3), 323–332 (2011).
[CrossRef] [PubMed]

B. T. Lee, M. Hutteman, S. Gioux, A. Stockdale, S. J. Lin, L. H. Ngo, J. V. Frangioni, “The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction,” Plast. Reconstr. Surg. 126(5), 1472–1481 (2010).
[CrossRef] [PubMed]

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G. C. Gurtner, G. E. Jones, P. C. Neligan, M. I. Newman, B. T. Phillips, J. M. Sacks, M. R. Zenn, “Intraoperative laser angiography using the SPY system: review of the literature and recommendations for use,” Ann. Surg. Innov. Res. 7(1), 1750–1764 (2013).
[CrossRef] [PubMed]

Kanick, S. C.

Kassiou, M.

S. R. Meikle, P. Kench, M. Kassiou, R. B. Banati, “Small animal SPECT and its place in the matrix of molecular imaging technologies,” Phys. Med. Biol. 50(22), R45–R61 (2005).
[CrossRef] [PubMed]

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G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[CrossRef] [PubMed]

Kench, P.

S. R. Meikle, P. Kench, M. Kassiou, R. B. Banati, “Small animal SPECT and its place in the matrix of molecular imaging technologies,” Phys. Med. Biol. 50(22), R45–R61 (2005).
[CrossRef] [PubMed]

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A. J. Fischman, R. H. Rubin, J. A. White, E. Locke, R. A. Wilkinson, M. Nedelman, R. J. Callahan, B. A. Khaw, H. W. Strauss, “Localization of Fc and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation,” J. Nucl. Med. 31(7), 1199–1205 (1990).
[PubMed]

Kobayashi, H.

R. Alford, H. M. Simpson, J. Duberman, G. C. Hill, M. Ogawa, C. Regino, H. Kobayashi, P. L. Choyke, “Toxicity of organic fluorophores used in molecular imaging: literature review,” Mol. Imaging 8(6), 341–354 (2009).
[PubMed]

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M. Yokouchi, M. Terahara, S. Nagano, Y. Arishima, M. Zemmyo, T. Yoshioka, A. Tanimoto, S. Komiya, “Clinical implications of determination of safe surgical margins by using a combination of CT and 18FDG-positron emission tomography in soft tissue sarcoma,” BMC Musculoskelet. Disord. 12(1), 166 (2011).
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T. J. Ruers, B. Wiering, J. R. van der Sijp, R. M. Roumen, K. P. de Jong, E. F. Comans, J. Pruim, H. M. Dekker, P. F. Krabbe, W. J. Oyen, “Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study,” J. Nucl. Med. 50(7), 1036–1041 (2009).
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J. Kuil, A. H. Velders, F. W. van Leeuwen, “Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label,” Bioconjug. Chem. 21(10), 1709–1719 (2010).
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B. E. Schaafsma, J. S. Mieog, M. Hutteman, J. R. van der Vorst, P. J. Kuppen, C. W. Löwik, J. V. Frangioni, C. J. van de Velde, A. L. Vahrmeijer, “The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery,” J. Surg. Oncol. 104(3), 323–332 (2011).
[CrossRef] [PubMed]

Kwon, S.

J. C. Rasmussen, S. Kwon, E. M. Sevick-Muraca, J. N. Cormier, “The role of lymphatics in cancer as assessed by near-infrared fluorescence imaging,” Ann. Biomed. Eng. 40(2), 408–421 (2012).
[CrossRef] [PubMed]

Landon, B. E.

M. B. Rosenthal, B. E. Landon, K. Howitt, H. R. Song, A. M. Epstein, “Climbing the pay-for performance learning curve: where are the early adopters now?” Health Aff. 26(6), 1674–1682 (2007).
[CrossRef]

Lee, B. T.

B. T. Lee, M. Hutteman, S. Gioux, A. Stockdale, S. J. Lin, L. H. Ngo, J. V. Frangioni, “The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction,” Plast. Reconstr. Surg. 126(5), 1472–1481 (2010).
[CrossRef] [PubMed]

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T. K. Lewellen, “Recent developments in PET detector technology,” Phys. Med. Biol. 53(17), R287–R317 (2008).
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Li, C. Q.

G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Q. Li, S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Phil. Trans. Roy. Soc. A. 369(1955), 4605–4619 (2011).

C. Q. Li, Y. F. Yang, G. S. Mitchell, S. R. Cherry, “Simultaneous PET and multispectral 3-dimensional fluorescence optical tomography imaging system,” J. Nucl. Med. 52(8), 1268–1275 (2011).
[CrossRef] [PubMed]

Lin, S. J.

B. T. Lee, M. Hutteman, S. Gioux, A. Stockdale, S. J. Lin, L. H. Ngo, J. V. Frangioni, “The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction,” Plast. Reconstr. Surg. 126(5), 1472–1481 (2010).
[CrossRef] [PubMed]

Liu, H.

Y. Xu, H. Liu, Z. Cheng, “Harnessing the power of radionuclides for optical imaging: Cerenkov luminescence imaging,” J. Nucl. Med. 52(12), 2009–2018 (2011).
[CrossRef] [PubMed]

Locke, E.

A. J. Fischman, R. H. Rubin, J. A. White, E. Locke, R. A. Wilkinson, M. Nedelman, R. J. Callahan, B. A. Khaw, H. W. Strauss, “Localization of Fc and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation,” J. Nucl. Med. 31(7), 1199–1205 (1990).
[PubMed]

Lorenzi, N. M.

B. C. Drolet, N. M. Lorenzi, “Translational research: understanding the continuum from bench to bedside,” Transl. Res. 157(1), 1–5 (2011).
[CrossRef] [PubMed]

Low, P. S.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[CrossRef] [PubMed]

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B. E. Schaafsma, J. S. Mieog, M. Hutteman, J. R. van der Vorst, P. J. Kuppen, C. W. Löwik, J. V. Frangioni, C. J. van de Velde, A. L. Vahrmeijer, “The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery,” J. Surg. Oncol. 104(3), 323–332 (2011).
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Polom, K.

K. Polom, D. Murawa, Y. S. Rho, P. Nowaczyk, M. Hünerbein, P. Murawa, “Current trends and emerging future of indocyanine green usage in surgery and oncology,” Cancer 117(21), 4812–4822 (2011).
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J. C. Rasmussen, S. Kwon, E. M. Sevick-Muraca, J. N. Cormier, “The role of lymphatics in cancer as assessed by near-infrared fluorescence imaging,” Ann. Biomed. Eng. 40(2), 408–421 (2012).
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M. V. Marshall, J. C. Rasmussen, I.-C. Tan, M. B. Aldrich, K. E. Adams, X. Wang, C. E. Fife, E. A. Maus, L. A. Smith, E. M. Sevick-Muraca, “Near-infrared fluorescence imaging in humans with indocyanine green: a review and update,” Open Surg Oncol J 2(2), 12–25 (2010).
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E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
[CrossRef] [PubMed]

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R. Alford, H. M. Simpson, J. Duberman, G. C. Hill, M. Ogawa, C. Regino, H. Kobayashi, P. L. Choyke, “Toxicity of organic fluorophores used in molecular imaging: literature review,” Mol. Imaging 8(6), 341–354 (2009).
[PubMed]

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K. Polom, D. Murawa, Y. S. Rho, P. Nowaczyk, M. Hünerbein, P. Murawa, “Current trends and emerging future of indocyanine green usage in surgery and oncology,” Cancer 117(21), 4812–4822 (2011).
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S. C. Ghosh, P. Ghosh, N. Wilganowski, H. Robinson, M. A. Hall, G. Dickinson, K. L. Pinkston, B. R. Harvey, E. M. Sevick-Muraca, A. Azhdarinia, “Multimodal chelation platform for near-infrared fluorescence/nuclear imaging,” J. Med. Chem. 56(2), 406–416 (2013).
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M. B. Rosenthal, B. E. Landon, K. Howitt, H. R. Song, A. M. Epstein, “Climbing the pay-for performance learning curve: where are the early adopters now?” Health Aff. 26(6), 1674–1682 (2007).
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T. J. Ruers, B. Wiering, J. R. van der Sijp, R. M. Roumen, K. P. de Jong, E. F. Comans, J. Pruim, H. M. Dekker, P. F. Krabbe, W. J. Oyen, “Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study,” J. Nucl. Med. 50(7), 1036–1041 (2009).
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A. J. Fischman, R. H. Rubin, J. A. White, E. Locke, R. A. Wilkinson, M. Nedelman, R. J. Callahan, B. A. Khaw, H. W. Strauss, “Localization of Fc and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation,” J. Nucl. Med. 31(7), 1199–1205 (1990).
[PubMed]

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T. J. Ruers, B. Wiering, J. R. van der Sijp, R. M. Roumen, K. P. de Jong, E. F. Comans, J. Pruim, H. M. Dekker, P. F. Krabbe, W. J. Oyen, “Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study,” J. Nucl. Med. 50(7), 1036–1041 (2009).
[CrossRef] [PubMed]

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G. C. Gurtner, G. E. Jones, P. C. Neligan, M. I. Newman, B. T. Phillips, J. M. Sacks, M. R. Zenn, “Intraoperative laser angiography using the SPY system: review of the literature and recommendations for use,” Ann. Surg. Innov. Res. 7(1), 1750–1764 (2013).
[CrossRef] [PubMed]

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E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
[CrossRef] [PubMed]

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G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
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[CrossRef] [PubMed]

J. C. Rasmussen, S. Kwon, E. M. Sevick-Muraca, J. N. Cormier, “The role of lymphatics in cancer as assessed by near-infrared fluorescence imaging,” Ann. Biomed. Eng. 40(2), 408–421 (2012).
[CrossRef] [PubMed]

M. V. Marshall, J. C. Rasmussen, I.-C. Tan, M. B. Aldrich, K. E. Adams, X. Wang, C. E. Fife, E. A. Maus, L. A. Smith, E. M. Sevick-Muraca, “Near-infrared fluorescence imaging in humans with indocyanine green: a review and update,” Open Surg Oncol J 2(2), 12–25 (2010).
[CrossRef] [PubMed]

E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
[CrossRef] [PubMed]

Sharma, R.

E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
[CrossRef] [PubMed]

Sheng, P. Y.

A. Barros, M. A. Cardoso, P. Y. Sheng, P. A. Costa, C. Pelizon, “Radioguided localisation of non-palpable breast lesions and simultaneous sentinel lymph node mapping,” Eur. J. Nucl. Med. Mol. Imaging 29(12), 1561–1565 (2002).
[CrossRef] [PubMed]

Silverman, R. W.

A. Douraghy, F. R. Rannou, R. W. Silverman, A. F. Chatziioannou, “FPGA electronics for OPET: a dual modality optical and positron emission tomography,” IEEE Trans. Nucl. Sci. 55(5), 2541–2545 (2008).
[CrossRef]

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R. Alford, H. M. Simpson, J. Duberman, G. C. Hill, M. Ogawa, C. Regino, H. Kobayashi, P. L. Choyke, “Toxicity of organic fluorophores used in molecular imaging: literature review,” Mol. Imaging 8(6), 341–354 (2009).
[PubMed]

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M. V. Marshall, J. C. Rasmussen, I.-C. Tan, M. B. Aldrich, K. E. Adams, X. Wang, C. E. Fife, E. A. Maus, L. A. Smith, E. M. Sevick-Muraca, “Near-infrared fluorescence imaging in humans with indocyanine green: a review and update,” Open Surg Oncol J 2(2), 12–25 (2010).
[CrossRef] [PubMed]

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M. B. Rosenthal, B. E. Landon, K. Howitt, H. R. Song, A. M. Epstein, “Climbing the pay-for performance learning curve: where are the early adopters now?” Health Aff. 26(6), 1674–1682 (2007).
[CrossRef]

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B. T. Lee, M. Hutteman, S. Gioux, A. Stockdale, S. J. Lin, L. H. Ngo, J. V. Frangioni, “The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction,” Plast. Reconstr. Surg. 126(5), 1472–1481 (2010).
[CrossRef] [PubMed]

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A. J. Fischman, R. H. Rubin, J. A. White, E. Locke, R. A. Wilkinson, M. Nedelman, R. J. Callahan, B. A. Khaw, H. W. Strauss, “Localization of Fc and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation,” J. Nucl. Med. 31(7), 1199–1205 (1990).
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S. R. Tunis, D. B. Stryer, C. M. Clancy, “Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy,” J. Am. Med. Assoc. 290(12), 1624–1632 (2003).
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M. V. Marshall, J. C. Rasmussen, I.-C. Tan, M. B. Aldrich, K. E. Adams, X. Wang, C. E. Fife, E. A. Maus, L. A. Smith, E. M. Sevick-Muraca, “Near-infrared fluorescence imaging in humans with indocyanine green: a review and update,” Open Surg Oncol J 2(2), 12–25 (2010).
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M. Yokouchi, M. Terahara, S. Nagano, Y. Arishima, M. Zemmyo, T. Yoshioka, A. Tanimoto, S. Komiya, “Clinical implications of determination of safe surgical margins by using a combination of CT and 18FDG-positron emission tomography in soft tissue sarcoma,” BMC Musculoskelet. Disord. 12(1), 166 (2011).
[CrossRef] [PubMed]

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M. Yokouchi, M. Terahara, S. Nagano, Y. Arishima, M. Zemmyo, T. Yoshioka, A. Tanimoto, S. Komiya, “Clinical implications of determination of safe surgical margins by using a combination of CT and 18FDG-positron emission tomography in soft tissue sarcoma,” BMC Musculoskelet. Disord. 12(1), 166 (2011).
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G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[CrossRef] [PubMed]

Tunis, S. R.

S. R. Tunis, D. B. Stryer, C. M. Clancy, “Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy,” J. Am. Med. Assoc. 290(12), 1624–1632 (2003).
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Vahrmeijer, A. L.

B. E. Schaafsma, J. S. Mieog, M. Hutteman, J. R. van der Vorst, P. J. Kuppen, C. W. Löwik, J. V. Frangioni, C. J. van de Velde, A. L. Vahrmeijer, “The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery,” J. Surg. Oncol. 104(3), 323–332 (2011).
[CrossRef] [PubMed]

van Dam, G. M.

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[CrossRef] [PubMed]

van de Velde, C. J.

B. E. Schaafsma, J. S. Mieog, M. Hutteman, J. R. van der Vorst, P. J. Kuppen, C. W. Löwik, J. V. Frangioni, C. J. van de Velde, A. L. Vahrmeijer, “The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery,” J. Surg. Oncol. 104(3), 323–332 (2011).
[CrossRef] [PubMed]

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T. J. Ruers, B. Wiering, J. R. van der Sijp, R. M. Roumen, K. P. de Jong, E. F. Comans, J. Pruim, H. M. Dekker, P. F. Krabbe, W. J. Oyen, “Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study,” J. Nucl. Med. 50(7), 1036–1041 (2009).
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van der Vorst, J. R.

B. E. Schaafsma, J. S. Mieog, M. Hutteman, J. R. van der Vorst, P. J. Kuppen, C. W. Löwik, J. V. Frangioni, C. J. van de Velde, A. L. Vahrmeijer, “The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery,” J. Surg. Oncol. 104(3), 323–332 (2011).
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G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[CrossRef] [PubMed]

van Leeuwen, F. W.

J. Kuil, A. H. Velders, F. W. van Leeuwen, “Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label,” Bioconjug. Chem. 21(10), 1709–1719 (2010).
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VanBrocklin, H. F.

H. F. VanBrocklin, “Radiopharmaceuticals for drug development: United States regulatory perspective,” Current Radiopharmaceuticals 1(1), 2–6 (2008).
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Velders, A. H.

J. Kuil, A. H. Velders, F. W. van Leeuwen, “Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label,” Bioconjug. Chem. 21(10), 1709–1719 (2010).
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Vizard, D.

W. McLaughlin, D. Vizard, “Kodak in vivo imaging system: precise co-registration of molecular imaging with anatomical x-ray imaging,” Nat. Methods 5, 26–28 (2006).

Wang, X.

M. V. Marshall, J. C. Rasmussen, I.-C. Tan, M. B. Aldrich, K. E. Adams, X. Wang, C. E. Fife, E. A. Maus, L. A. Smith, E. M. Sevick-Muraca, “Near-infrared fluorescence imaging in humans with indocyanine green: a review and update,” Open Surg Oncol J 2(2), 12–25 (2010).
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R. E. Weiner, M. L. Thakur, “Radiolabeled peptides in oncology: role in diagnosis and treatment,” BioDrugs 19(3), 145–163 (2005).
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E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
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White, J. A.

A. J. Fischman, R. H. Rubin, J. A. White, E. Locke, R. A. Wilkinson, M. Nedelman, R. J. Callahan, B. A. Khaw, H. W. Strauss, “Localization of Fc and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation,” J. Nucl. Med. 31(7), 1199–1205 (1990).
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T. J. Ruers, B. Wiering, J. R. van der Sijp, R. M. Roumen, K. P. de Jong, E. F. Comans, J. Pruim, H. M. Dekker, P. F. Krabbe, W. J. Oyen, “Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study,” J. Nucl. Med. 50(7), 1036–1041 (2009).
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Wilganowski, N.

S. C. Ghosh, P. Ghosh, N. Wilganowski, H. Robinson, M. A. Hall, G. Dickinson, K. L. Pinkston, B. R. Harvey, E. M. Sevick-Muraca, A. Azhdarinia, “Multimodal chelation platform for near-infrared fluorescence/nuclear imaging,” J. Med. Chem. 56(2), 406–416 (2013).
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A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol. 14(3), 261–276 (2012).
[CrossRef] [PubMed]

Wilkinson, R. A.

A. J. Fischman, R. H. Rubin, J. A. White, E. Locke, R. A. Wilkinson, M. Nedelman, R. J. Callahan, B. A. Khaw, H. W. Strauss, “Localization of Fc and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation,” J. Nucl. Med. 31(7), 1199–1205 (1990).
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S. Wolf, “Editorial: The real gap between bench and bedside,” N. Engl. J. Med. 290(14), 802–803 (1974).
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Wu, A. M.

A. M. Wu, “Antibodies and antimatter: the resurgence of immuno-PET,” J. Nucl. Med. 50(1), 2–5 (2008).
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Xu, Y.

Y. Xu, H. Liu, Z. Cheng, “Harnessing the power of radionuclides for optical imaging: Cerenkov luminescence imaging,” J. Nucl. Med. 52(12), 2009–2018 (2011).
[CrossRef] [PubMed]

Yang, Y. F.

C. Q. Li, Y. F. Yang, G. S. Mitchell, S. R. Cherry, “Simultaneous PET and multispectral 3-dimensional fluorescence optical tomography imaging system,” J. Nucl. Med. 52(8), 1268–1275 (2011).
[CrossRef] [PubMed]

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M. Yokouchi, M. Terahara, S. Nagano, Y. Arishima, M. Zemmyo, T. Yoshioka, A. Tanimoto, S. Komiya, “Clinical implications of determination of safe surgical margins by using a combination of CT and 18FDG-positron emission tomography in soft tissue sarcoma,” BMC Musculoskelet. Disord. 12(1), 166 (2011).
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M. Yokouchi, M. Terahara, S. Nagano, Y. Arishima, M. Zemmyo, T. Yoshioka, A. Tanimoto, S. Komiya, “Clinical implications of determination of safe surgical margins by using a combination of CT and 18FDG-positron emission tomography in soft tissue sarcoma,” BMC Musculoskelet. Disord. 12(1), 166 (2011).
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M. Yokouchi, M. Terahara, S. Nagano, Y. Arishima, M. Zemmyo, T. Yoshioka, A. Tanimoto, S. Komiya, “Clinical implications of determination of safe surgical margins by using a combination of CT and 18FDG-positron emission tomography in soft tissue sarcoma,” BMC Musculoskelet. Disord. 12(1), 166 (2011).
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G. C. Gurtner, G. E. Jones, P. C. Neligan, M. I. Newman, B. T. Phillips, J. M. Sacks, M. R. Zenn, “Intraoperative laser angiography using the SPY system: review of the literature and recommendations for use,” Ann. Surg. Innov. Res. 7(1), 1750–1764 (2013).
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E. A. Zerhouni, “Translational research: moving discovery to practice,” Clin. Pharmacol. Ther. 81(1), 126–128 (2007).
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Zhang, R.

Ann. Biomed. Eng. (1)

J. C. Rasmussen, S. Kwon, E. M. Sevick-Muraca, J. N. Cormier, “The role of lymphatics in cancer as assessed by near-infrared fluorescence imaging,” Ann. Biomed. Eng. 40(2), 408–421 (2012).
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Ann. Surg. Innov. Res. (1)

G. C. Gurtner, G. E. Jones, P. C. Neligan, M. I. Newman, B. T. Phillips, J. M. Sacks, M. R. Zenn, “Intraoperative laser angiography using the SPY system: review of the literature and recommendations for use,” Ann. Surg. Innov. Res. 7(1), 1750–1764 (2013).
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Annu. Rev. Med. (1)

E. M. Sevick-Muraca, “Translation of near-infrared fluorescence imaging technologies: emerging clinical applications,” Annu. Rev. Med. 63(1), 217–231 (2012).
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Bioconjug. Chem. (1)

J. Kuil, A. H. Velders, F. W. van Leeuwen, “Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label,” Bioconjug. Chem. 21(10), 1709–1719 (2010).
[CrossRef] [PubMed]

BioDrugs (1)

R. E. Weiner, M. L. Thakur, “Radiolabeled peptides in oncology: role in diagnosis and treatment,” BioDrugs 19(3), 145–163 (2005).
[CrossRef] [PubMed]

Biomed. Opt. Express (1)

BMC Musculoskelet. Disord. (1)

M. Yokouchi, M. Terahara, S. Nagano, Y. Arishima, M. Zemmyo, T. Yoshioka, A. Tanimoto, S. Komiya, “Clinical implications of determination of safe surgical margins by using a combination of CT and 18FDG-positron emission tomography in soft tissue sarcoma,” BMC Musculoskelet. Disord. 12(1), 166 (2011).
[CrossRef] [PubMed]

Cancer (1)

K. Polom, D. Murawa, Y. S. Rho, P. Nowaczyk, M. Hünerbein, P. Murawa, “Current trends and emerging future of indocyanine green usage in surgery and oncology,” Cancer 117(21), 4812–4822 (2011).
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Clin. Pharmacol. Ther. (1)

E. A. Zerhouni, “Translational research: moving discovery to practice,” Clin. Pharmacol. Ther. 81(1), 126–128 (2007).
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Current Radiopharmaceuticals (1)

H. F. VanBrocklin, “Radiopharmaceuticals for drug development: United States regulatory perspective,” Current Radiopharmaceuticals 1(1), 2–6 (2008).
[CrossRef]

Eur. J. Nucl. Med. Mol. Imaging (1)

A. Barros, M. A. Cardoso, P. Y. Sheng, P. A. Costa, C. Pelizon, “Radioguided localisation of non-palpable breast lesions and simultaneous sentinel lymph node mapping,” Eur. J. Nucl. Med. Mol. Imaging 29(12), 1561–1565 (2002).
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Health Aff. (1)

M. B. Rosenthal, B. E. Landon, K. Howitt, H. R. Song, A. M. Epstein, “Climbing the pay-for performance learning curve: where are the early adopters now?” Health Aff. 26(6), 1674–1682 (2007).
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IEEE Trans. Nucl. Sci. (1)

A. Douraghy, F. R. Rannou, R. W. Silverman, A. F. Chatziioannou, “FPGA electronics for OPET: a dual modality optical and positron emission tomography,” IEEE Trans. Nucl. Sci. 55(5), 2541–2545 (2008).
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A. D. Nunn, “The cost of developing imaging agents for routine clinical use,” Invest. Radiol. 41(3), 206–212 (2006).
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S. Achilefu, R. B. Dorshow, J. E. Bugaj, R. Rajagopalan, “Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging,” Invest. Radiol. 35(8), 479–485 (2000).
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J. Am. Med. Assoc. (1)

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J. Med. Chem. (1)

S. C. Ghosh, P. Ghosh, N. Wilganowski, H. Robinson, M. A. Hall, G. Dickinson, K. L. Pinkston, B. R. Harvey, E. M. Sevick-Muraca, A. Azhdarinia, “Multimodal chelation platform for near-infrared fluorescence/nuclear imaging,” J. Med. Chem. 56(2), 406–416 (2013).
[CrossRef] [PubMed]

J. Nucl. Med. (6)

A. M. Wu, “Antibodies and antimatter: the resurgence of immuno-PET,” J. Nucl. Med. 50(1), 2–5 (2008).
[CrossRef] [PubMed]

Y. Xu, H. Liu, Z. Cheng, “Harnessing the power of radionuclides for optical imaging: Cerenkov luminescence imaging,” J. Nucl. Med. 52(12), 2009–2018 (2011).
[CrossRef] [PubMed]

T. J. Ruers, B. Wiering, J. R. van der Sijp, R. M. Roumen, K. P. de Jong, E. F. Comans, J. Pruim, H. M. Dekker, P. F. Krabbe, W. J. Oyen, “Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study,” J. Nucl. Med. 50(7), 1036–1041 (2009).
[CrossRef] [PubMed]

C. Q. Li, Y. F. Yang, G. S. Mitchell, S. R. Cherry, “Simultaneous PET and multispectral 3-dimensional fluorescence optical tomography imaging system,” J. Nucl. Med. 52(8), 1268–1275 (2011).
[CrossRef] [PubMed]

J. Culver, W. Akers, S. Achilefu, “Multimodality molecular imaging with combined optical and SPECT/PET modalities,” J. Nucl. Med. 49(2), 169–172 (2008).
[CrossRef] [PubMed]

A. J. Fischman, R. H. Rubin, J. A. White, E. Locke, R. A. Wilkinson, M. Nedelman, R. J. Callahan, B. A. Khaw, H. W. Strauss, “Localization of Fc and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation,” J. Nucl. Med. 31(7), 1199–1205 (1990).
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J. Surg. Oncol. (1)

B. E. Schaafsma, J. S. Mieog, M. Hutteman, J. R. van der Vorst, P. J. Kuppen, C. W. Löwik, J. V. Frangioni, C. J. van de Velde, A. L. Vahrmeijer, “The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery,” J. Surg. Oncol. 104(3), 323–332 (2011).
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JAMA (1)

D. Dougherty, P. H. Conway, “The “3T’s” road map to transform US health care: the “how” of high-quality care,” JAMA 299(19), 2319–2321 (2008).
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Mol. Imaging (1)

R. Alford, H. M. Simpson, J. Duberman, G. C. Hill, M. Ogawa, C. Regino, H. Kobayashi, P. L. Choyke, “Toxicity of organic fluorophores used in molecular imaging: literature review,” Mol. Imaging 8(6), 341–354 (2009).
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Mol. Imaging Biol. (1)

A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol. 14(3), 261–276 (2012).
[CrossRef] [PubMed]

N. Engl. J. Med. (1)

S. Wolf, “Editorial: The real gap between bench and bedside,” N. Engl. J. Med. 290(14), 802–803 (1974).
[CrossRef] [PubMed]

Nat. Med. (1)

G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[CrossRef] [PubMed]

Nat. Methods (1)

W. McLaughlin, D. Vizard, “Kodak in vivo imaging system: precise co-registration of molecular imaging with anatomical x-ray imaging,” Nat. Methods 5, 26–28 (2006).

Open Surg Oncol J (1)

M. V. Marshall, J. C. Rasmussen, I.-C. Tan, M. B. Aldrich, K. E. Adams, X. Wang, C. E. Fife, E. A. Maus, L. A. Smith, E. M. Sevick-Muraca, “Near-infrared fluorescence imaging in humans with indocyanine green: a review and update,” Open Surg Oncol J 2(2), 12–25 (2010).
[CrossRef] [PubMed]

Phil. Trans. Roy. Soc. A. (1)

G. S. Mitchell, R. K. Gill, D. L. Boucher, C. Q. Li, S. R. Cherry, “In vivo Cerenkov luminescence imaging: a new tool for molecular imaging,” Phil. Trans. Roy. Soc. A. 369(1955), 4605–4619 (2011).

Phys. Med. Biol. (3)

L. J. Cao, J. Peter, “Bayesian reconstruction strategy of fluorescence-mediated tomography using an integrated SPECT-CT-OT system,” Phys. Med. Biol. 55(9), 2693–2708 (2010).
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T. K. Lewellen, “Recent developments in PET detector technology,” Phys. Med. Biol. 53(17), R287–R317 (2008).
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S. R. Meikle, P. Kench, M. Kassiou, R. B. Banati, “Small animal SPECT and its place in the matrix of molecular imaging technologies,” Phys. Med. Biol. 50(22), R45–R61 (2005).
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Plast. Reconstr. Surg. (1)

B. T. Lee, M. Hutteman, S. Gioux, A. Stockdale, S. J. Lin, L. H. Ngo, J. V. Frangioni, “The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction,” Plast. Reconstr. Surg. 126(5), 1472–1481 (2010).
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Radiology (1)

E. M. Sevick-Muraca, R. Sharma, J. C. Rasmussen, M. V. Marshall, J. A. Wendt, H. Q. Pham, E. Bonefas, J. P. Houston, L. Sampath, K. E. Adams, D. K. Blanchard, R. E. Fisher, S. B. Chiang, R. Elledge, M. E. Mawad, “Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study,” Radiology 246(3), 734–741 (2008).
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Transl. Res. (1)

B. C. Drolet, N. M. Lorenzi, “Translational research: understanding the continuum from bench to bedside,” Transl. Res. 157(1), 1–5 (2011).
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H. Kudrolli, H. B. Bhandari, K. L. Byrne, S. R. Cherry, G. S. Mitchell, H. Sabet, and V. Nagarkar, “A novel sensor for high throughput preclinical radiotracer imaging,” Proc. SPIE 2013; 8668, Medical Imaging 2013: Physics of Medical Imaging 866809.

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