Abstract

We demonstrate a cytotoxicity evaluation of tissue adhesive using Raman spectroscopy. This method allows for quantitative, label-free, non-invasive and rapid monitoring of the biochemical changes of cells following tissue adhesive treatment. Here, we show the biochemical property changes in mouse fibroblast L929 cells and cellular DNA following tissue adhesive (Dermabond) treatment using Raman spectroscopy. The Raman band intensities were significantly decreased when the cells were treated with Dermabond as compared to control cells. These results suggest denaturation and conformational changes in proteins and degradation of DNA related to cell death. To support these conclusions, conventional cytotoxicity assays such as WST, LIVE/DEAD, and TUNEL were carried out, and the results were in agreement with the Raman results. Thus, Raman spectroscopy analysis not only distinguishes between viable and damaged cells, but can also be used for identification and quantification of a cytotoxicity of tissue adhesive, which based on the cellular biochemical and structural changes at a molecular level. Therefore, we suggest that this method could be used for cytotoxic evaluation of tissue adhesives by rapid and sensitive detection of cellular changes.

© 2013 Optical Society of America

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  1. J. S. Applebaum, T. Zalut, D. Applebaum, “The use of tissue adhesion for traumatic laceration repair in the emergency department,” Ann. Emerg. Med. 22(7), 1190–1192 (1993).
    [CrossRef] [PubMed]
  2. A. B. Leahey, J. D. Gottsch, W. J. Stark, “Clinical experience with N-butyl cyanoacrylate (Nexacryl) tissue adhesive,” Ophthalmology 100(2), 173–180 (1993).
    [PubMed]
  3. L. P. Blanco, “Lip suture with isobutyl cyanoacrylate,” Endod. Dent. Traumatol. 10(1), 15–18 (1994).
    [CrossRef] [PubMed]
  4. P. A. Leggat, D. R. Smith, U. Kedjarune, “Surgical applications of cyanoacrylate adhesives: a review of toxicity,” ANZ J. Surg. 77(4), 209–213 (2007).
    [CrossRef] [PubMed]
  5. B. J. Vote, M. J. Elder, “Cyanoacrylate glue for corneal perforations: a description of a surgical technique and a review of the literature,” Clin. Experiment. Ophthalmol. 28(6), 437–442 (2000).
    [CrossRef] [PubMed]
  6. J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
    [CrossRef]
  7. S. Dochow, C. Krafft, U. Neugebauer, T. Bocklitz, T. Henkel, G. Mayer, J. Albert, J. Popp, “Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environments,” Lab Chip 11(8), 1484–1490 (2011).
    [CrossRef] [PubMed]
  8. J. Schenk, L. Tröbs, F. Emmerling, J. Kneipp, U. Panne, M. Albrecht, “Simultaneous UV/Vis spectroscopy and surface enhanced Raman scattering of nanoparticle formation and aggregation in levitated droplets,” Anal. Methods 4(5), 1252–1258 (2012).
    [CrossRef]
  9. W. A. El-Said, T. H. Kim, H. C. Kim, J. W. Choi, “Analysis of intracellular state based on controlled 3D nanostructures mediated surface enhanced Raman scattering,” PLoS ONE 6(2), e15836 (2011).
    [CrossRef] [PubMed]
  10. M. M. Mariani, P. J. Day, V. Deckert, “Applications of modern micro-Raman spectroscopy for cell analyses,” Integr Biol (Camb) 2(2-3), 94–101 (2010).
    [CrossRef] [PubMed]
  11. J. Lin, R. Chen, S. Feng, Y. Li, Z. Huang, S. Xie, Y. Yu, M. Cheng, H. Zeng, “Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy,” Biosens. Bioelectron. 25(2), 388–394 (2009).
    [CrossRef] [PubMed]
  12. L. Chen, X. X. Han, Z. Guo, X. Wang, W. Ruan, W. Song, B. Zhao, Y. Ozaki, “Biomagnetic glass beads for protein separation and detection based on surface-enhanced Raman scattering,” Anal. Methods 4(6), 1643–1647 (2012).
    [CrossRef]
  13. S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
    [CrossRef] [PubMed]
  14. J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
    [CrossRef] [PubMed]
  15. I. Notingher, J. Selvakumaran, L. L. Hench, “New detection system for toxic agents based on continuous spectroscopic monitoring of living cells,” Biosens. Bioelectron. 20(4), 780–789 (2004).
    [CrossRef] [PubMed]
  16. A. D. Ghanate, S. Kothiwale, S. P. Singh, D. Bertrand, C. M. Krishna, “Comparative evaluation of spectroscopic models using different multivariate statistical tools in a multicancer scenario,” J. Biomed. Opt. 16(2), 025003 (2011).
    [CrossRef] [PubMed]
  17. A. J. Makowski, C. A. Patil, A. Mahadevan-Jansen, J. S. Nyman, “Polarization control of Raman spectroscopy optimizes the assessment of bone tissue,” J. Biomed. Opt. 18(5), 055005 (2013).
    [CrossRef] [PubMed]
  18. J. W. Kang, N. Lue, C. R. Kong, I. Barman, N. C. Dingari, S. J. Goldfless, J. C. Niles, R. R. Dasari, M. S. Feld, “Combined confocal Raman and quantitative phase microscopy system for biomedical diagnosis,” Biomed. Opt. Express 2(9), 2484–2492 (2011).
    [CrossRef] [PubMed]
  19. I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
    [CrossRef] [PubMed]
  20. M. S. Bergholt, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, J. B. Y. So, A. Shabbir, Z. Huang, “Fiber-optic Raman spectroscopy probes gastric carcinogenesis in vivo at endoscopy,” J Biophotonics 6(1), 49–59 (2013).
    [CrossRef] [PubMed]
  21. A. D. Meade, C. Clarke, F. Draux, G. D. Sockalingum, M. Manfait, F. M. Lyng, H. J. Byrne, “Studies of chemical fixation effects in human cell lines using Raman microspectroscopy,” Anal. Bioanal. Chem. 396(5), 1781–1791 (2010).
    [CrossRef] [PubMed]
  22. J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
    [CrossRef]
  23. Y. Yu, J. Lin, Y. Wu, S. Feng, Y. Li, Z. Huang, R. Chen, H. Zeng, “Optimizing electroporation assisted silver nanoparticle delivery into living C666 cells for surface-enhanced Raman spectroscopy,” Spectroscopy 25(1), 13–21 (2011).
    [CrossRef]
  24. H. N. Yehia, R. K. Draper, C. Mikoryak, E. K. Walker, P. Bajaj, I. H. Musselman, M. C. Daigrepont, G. R. Dieckmann, P. Pantano, “Single-walled carbon nanotube interactions with HeLa cells,” J. Nanobiotechnology 5(1), 8 (2007).
    [CrossRef] [PubMed]
  25. T. J. Moritz, D. S. Taylor, D. M. Krol, J. Fritch, J. W. Chan, “Detection of doxorubicin-induced apoptosis of leukemic T-lymphocytes by laser tweezers Raman spectroscopy,” Biomed. Opt. Express 1(4), 1138–1147 (2010).
    [CrossRef] [PubMed]
  26. H. Huang, H. Shi, S. Feng, W. Chen, Y. Yu, D. Lin, R. Chen, “Confocal Raman spectroscopic analysis of the cytotoxic response to cisplatin in nasopharyngeal carcinoma cells,” Anal. Methods 5(1), 260–266 (2012).
    [CrossRef]
  27. P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).
  28. Q. Matthews, A. Jirasek, J. Lum, X. Duan, A. G. Brolo, “Variability in Raman spectra of single human tumor cells cultured in vitro: correlation with cell cycle and culture confluency,” Appl. Spectrosc. 64(8), 871–887 (2010).
    [CrossRef] [PubMed]
  29. J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
    [CrossRef] [PubMed]
  30. J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens, “Reference database of Raman spectra of biological molecules,” J. Raman Spectrosc. 38(9), 1133–1147 (2007).
    [CrossRef]
  31. C. A. Owen, J. Selvakumaran, I. Notingher, G. Jell, L. L. Hench, M. M. Stevens, “In vitro toxicology evaluation of pharmaceuticals using Raman micro-spectroscopy,” J. Cell. Biochem. 99(1), 178–186 (2006).
    [CrossRef] [PubMed]
  32. I. Notingher, C. Green, C. Dyer, E. Perkins, N. Hopkins, C. Lindsay, L. L. Hench, “Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy,” J. R. Soc. Interface 1(1), 79–90 (2004).
    [CrossRef] [PubMed]
  33. J. Weyermann, D. Lochmann, A. Zimmer, “A practical note on the use of cytotoxicity assays,” Int. J. Pharm. 288(2), 369–376 (2005).
    [CrossRef] [PubMed]
  34. G. Fotakis, J. A. Timbrell, “In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride,” Toxicol. Lett. 160(2), 171–177 (2006).
    [CrossRef] [PubMed]
  35. S. K. Bhatia, A. B. Yetter, “Correlation of visual in vitro cytotoxicity ratings of biomaterials with quantitative in vitro cell viability measurements,” Cell Biol. Toxicol. 24(4), 315–319 (2008).
    [CrossRef] [PubMed]

2013

A. J. Makowski, C. A. Patil, A. Mahadevan-Jansen, J. S. Nyman, “Polarization control of Raman spectroscopy optimizes the assessment of bone tissue,” J. Biomed. Opt. 18(5), 055005 (2013).
[CrossRef] [PubMed]

I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
[CrossRef] [PubMed]

M. S. Bergholt, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, J. B. Y. So, A. Shabbir, Z. Huang, “Fiber-optic Raman spectroscopy probes gastric carcinogenesis in vivo at endoscopy,” J Biophotonics 6(1), 49–59 (2013).
[CrossRef] [PubMed]

2012

H. Huang, H. Shi, S. Feng, W. Chen, Y. Yu, D. Lin, R. Chen, “Confocal Raman spectroscopic analysis of the cytotoxic response to cisplatin in nasopharyngeal carcinoma cells,” Anal. Methods 5(1), 260–266 (2012).
[CrossRef]

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

J. Schenk, L. Tröbs, F. Emmerling, J. Kneipp, U. Panne, M. Albrecht, “Simultaneous UV/Vis spectroscopy and surface enhanced Raman scattering of nanoparticle formation and aggregation in levitated droplets,” Anal. Methods 4(5), 1252–1258 (2012).
[CrossRef]

L. Chen, X. X. Han, Z. Guo, X. Wang, W. Ruan, W. Song, B. Zhao, Y. Ozaki, “Biomagnetic glass beads for protein separation and detection based on surface-enhanced Raman scattering,” Anal. Methods 4(6), 1643–1647 (2012).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

2011

S. Dochow, C. Krafft, U. Neugebauer, T. Bocklitz, T. Henkel, G. Mayer, J. Albert, J. Popp, “Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environments,” Lab Chip 11(8), 1484–1490 (2011).
[CrossRef] [PubMed]

A. D. Ghanate, S. Kothiwale, S. P. Singh, D. Bertrand, C. M. Krishna, “Comparative evaluation of spectroscopic models using different multivariate statistical tools in a multicancer scenario,” J. Biomed. Opt. 16(2), 025003 (2011).
[CrossRef] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[CrossRef] [PubMed]

J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
[CrossRef] [PubMed]

W. A. El-Said, T. H. Kim, H. C. Kim, J. W. Choi, “Analysis of intracellular state based on controlled 3D nanostructures mediated surface enhanced Raman scattering,” PLoS ONE 6(2), e15836 (2011).
[CrossRef] [PubMed]

Y. Yu, J. Lin, Y. Wu, S. Feng, Y. Li, Z. Huang, R. Chen, H. Zeng, “Optimizing electroporation assisted silver nanoparticle delivery into living C666 cells for surface-enhanced Raman spectroscopy,” Spectroscopy 25(1), 13–21 (2011).
[CrossRef]

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

J. W. Kang, N. Lue, C. R. Kong, I. Barman, N. C. Dingari, S. J. Goldfless, J. C. Niles, R. R. Dasari, M. S. Feld, “Combined confocal Raman and quantitative phase microscopy system for biomedical diagnosis,” Biomed. Opt. Express 2(9), 2484–2492 (2011).
[CrossRef] [PubMed]

2010

A. D. Meade, C. Clarke, F. Draux, G. D. Sockalingum, M. Manfait, F. M. Lyng, H. J. Byrne, “Studies of chemical fixation effects in human cell lines using Raman microspectroscopy,” Anal. Bioanal. Chem. 396(5), 1781–1791 (2010).
[CrossRef] [PubMed]

Q. Matthews, A. Jirasek, J. Lum, X. Duan, A. G. Brolo, “Variability in Raman spectra of single human tumor cells cultured in vitro: correlation with cell cycle and culture confluency,” Appl. Spectrosc. 64(8), 871–887 (2010).
[CrossRef] [PubMed]

T. J. Moritz, D. S. Taylor, D. M. Krol, J. Fritch, J. W. Chan, “Detection of doxorubicin-induced apoptosis of leukemic T-lymphocytes by laser tweezers Raman spectroscopy,” Biomed. Opt. Express 1(4), 1138–1147 (2010).
[CrossRef] [PubMed]

M. M. Mariani, P. J. Day, V. Deckert, “Applications of modern micro-Raman spectroscopy for cell analyses,” Integr Biol (Camb) 2(2-3), 94–101 (2010).
[CrossRef] [PubMed]

2009

J. Lin, R. Chen, S. Feng, Y. Li, Z. Huang, S. Xie, Y. Yu, M. Cheng, H. Zeng, “Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy,” Biosens. Bioelectron. 25(2), 388–394 (2009).
[CrossRef] [PubMed]

2008

S. K. Bhatia, A. B. Yetter, “Correlation of visual in vitro cytotoxicity ratings of biomaterials with quantitative in vitro cell viability measurements,” Cell Biol. Toxicol. 24(4), 315–319 (2008).
[CrossRef] [PubMed]

2007

H. N. Yehia, R. K. Draper, C. Mikoryak, E. K. Walker, P. Bajaj, I. H. Musselman, M. C. Daigrepont, G. R. Dieckmann, P. Pantano, “Single-walled carbon nanotube interactions with HeLa cells,” J. Nanobiotechnology 5(1), 8 (2007).
[CrossRef] [PubMed]

J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens, “Reference database of Raman spectra of biological molecules,” J. Raman Spectrosc. 38(9), 1133–1147 (2007).
[CrossRef]

P. A. Leggat, D. R. Smith, U. Kedjarune, “Surgical applications of cyanoacrylate adhesives: a review of toxicity,” ANZ J. Surg. 77(4), 209–213 (2007).
[CrossRef] [PubMed]

2006

C. A. Owen, J. Selvakumaran, I. Notingher, G. Jell, L. L. Hench, M. M. Stevens, “In vitro toxicology evaluation of pharmaceuticals using Raman micro-spectroscopy,” J. Cell. Biochem. 99(1), 178–186 (2006).
[CrossRef] [PubMed]

G. Fotakis, J. A. Timbrell, “In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride,” Toxicol. Lett. 160(2), 171–177 (2006).
[CrossRef] [PubMed]

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[CrossRef] [PubMed]

2005

J. Weyermann, D. Lochmann, A. Zimmer, “A practical note on the use of cytotoxicity assays,” Int. J. Pharm. 288(2), 369–376 (2005).
[CrossRef] [PubMed]

2004

I. Notingher, C. Green, C. Dyer, E. Perkins, N. Hopkins, C. Lindsay, L. L. Hench, “Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy,” J. R. Soc. Interface 1(1), 79–90 (2004).
[CrossRef] [PubMed]

I. Notingher, J. Selvakumaran, L. L. Hench, “New detection system for toxic agents based on continuous spectroscopic monitoring of living cells,” Biosens. Bioelectron. 20(4), 780–789 (2004).
[CrossRef] [PubMed]

2000

B. J. Vote, M. J. Elder, “Cyanoacrylate glue for corneal perforations: a description of a surgical technique and a review of the literature,” Clin. Experiment. Ophthalmol. 28(6), 437–442 (2000).
[CrossRef] [PubMed]

1994

L. P. Blanco, “Lip suture with isobutyl cyanoacrylate,” Endod. Dent. Traumatol. 10(1), 15–18 (1994).
[CrossRef] [PubMed]

1993

J. S. Applebaum, T. Zalut, D. Applebaum, “The use of tissue adhesion for traumatic laceration repair in the emergency department,” Ann. Emerg. Med. 22(7), 1190–1192 (1993).
[CrossRef] [PubMed]

A. B. Leahey, J. D. Gottsch, W. J. Stark, “Clinical experience with N-butyl cyanoacrylate (Nexacryl) tissue adhesive,” Ophthalmology 100(2), 173–180 (1993).
[PubMed]

Albert, J.

S. Dochow, C. Krafft, U. Neugebauer, T. Bocklitz, T. Henkel, G. Mayer, J. Albert, J. Popp, “Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environments,” Lab Chip 11(8), 1484–1490 (2011).
[CrossRef] [PubMed]

Albrecht, M.

J. Schenk, L. Tröbs, F. Emmerling, J. Kneipp, U. Panne, M. Albrecht, “Simultaneous UV/Vis spectroscopy and surface enhanced Raman scattering of nanoparticle formation and aggregation in levitated droplets,” Anal. Methods 4(5), 1252–1258 (2012).
[CrossRef]

Applebaum, D.

J. S. Applebaum, T. Zalut, D. Applebaum, “The use of tissue adhesion for traumatic laceration repair in the emergency department,” Ann. Emerg. Med. 22(7), 1190–1192 (1993).
[CrossRef] [PubMed]

Applebaum, J. S.

J. S. Applebaum, T. Zalut, D. Applebaum, “The use of tissue adhesion for traumatic laceration repair in the emergency department,” Ann. Emerg. Med. 22(7), 1190–1192 (1993).
[CrossRef] [PubMed]

Bajaj, P.

H. N. Yehia, R. K. Draper, C. Mikoryak, E. K. Walker, P. Bajaj, I. H. Musselman, M. C. Daigrepont, G. R. Dieckmann, P. Pantano, “Single-walled carbon nanotube interactions with HeLa cells,” J. Nanobiotechnology 5(1), 8 (2007).
[CrossRef] [PubMed]

Barman, I.

I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
[CrossRef] [PubMed]

J. W. Kang, N. Lue, C. R. Kong, I. Barman, N. C. Dingari, S. J. Goldfless, J. C. Niles, R. R. Dasari, M. S. Feld, “Combined confocal Raman and quantitative phase microscopy system for biomedical diagnosis,” Biomed. Opt. Express 2(9), 2484–2492 (2011).
[CrossRef] [PubMed]

Bergholt, M. S.

M. S. Bergholt, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, J. B. Y. So, A. Shabbir, Z. Huang, “Fiber-optic Raman spectroscopy probes gastric carcinogenesis in vivo at endoscopy,” J Biophotonics 6(1), 49–59 (2013).
[CrossRef] [PubMed]

Bertrand, D.

A. D. Ghanate, S. Kothiwale, S. P. Singh, D. Bertrand, C. M. Krishna, “Comparative evaluation of spectroscopic models using different multivariate statistical tools in a multicancer scenario,” J. Biomed. Opt. 16(2), 025003 (2011).
[CrossRef] [PubMed]

Bhatia, S. K.

S. K. Bhatia, A. B. Yetter, “Correlation of visual in vitro cytotoxicity ratings of biomaterials with quantitative in vitro cell viability measurements,” Cell Biol. Toxicol. 24(4), 315–319 (2008).
[CrossRef] [PubMed]

Blanco, L. P.

L. P. Blanco, “Lip suture with isobutyl cyanoacrylate,” Endod. Dent. Traumatol. 10(1), 15–18 (1994).
[CrossRef] [PubMed]

Bocklitz, T.

S. Dochow, C. Krafft, U. Neugebauer, T. Bocklitz, T. Henkel, G. Mayer, J. Albert, J. Popp, “Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environments,” Lab Chip 11(8), 1484–1490 (2011).
[CrossRef] [PubMed]

Brolo, A. G.

Byrne, H. J.

A. D. Meade, C. Clarke, F. Draux, G. D. Sockalingum, M. Manfait, F. M. Lyng, H. J. Byrne, “Studies of chemical fixation effects in human cell lines using Raman microspectroscopy,” Anal. Bioanal. Chem. 396(5), 1781–1791 (2010).
[CrossRef] [PubMed]

Candeloro Luca Tirinato, P.

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

Casals, E.

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

Chan, J. W.

T. J. Moritz, D. S. Taylor, D. M. Krol, J. Fritch, J. W. Chan, “Detection of doxorubicin-induced apoptosis of leukemic T-lymphocytes by laser tweezers Raman spectroscopy,” Biomed. Opt. Express 1(4), 1138–1147 (2010).
[CrossRef] [PubMed]

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[CrossRef] [PubMed]

Chen, G.

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
[CrossRef] [PubMed]

Chen, J.

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[CrossRef] [PubMed]

Chen, L.

L. Chen, X. X. Han, Z. Guo, X. Wang, W. Ruan, W. Song, B. Zhao, Y. Ozaki, “Biomagnetic glass beads for protein separation and detection based on surface-enhanced Raman scattering,” Anal. Methods 4(6), 1643–1647 (2012).
[CrossRef]

Chen, R.

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

H. Huang, H. Shi, S. Feng, W. Chen, Y. Yu, D. Lin, R. Chen, “Confocal Raman spectroscopic analysis of the cytotoxic response to cisplatin in nasopharyngeal carcinoma cells,” Anal. Methods 5(1), 260–266 (2012).
[CrossRef]

Y. Yu, J. Lin, Y. Wu, S. Feng, Y. Li, Z. Huang, R. Chen, H. Zeng, “Optimizing electroporation assisted silver nanoparticle delivery into living C666 cells for surface-enhanced Raman spectroscopy,” Spectroscopy 25(1), 13–21 (2011).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
[CrossRef] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[CrossRef] [PubMed]

J. Lin, R. Chen, S. Feng, Y. Li, Z. Huang, S. Xie, Y. Yu, M. Cheng, H. Zeng, “Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy,” Biosens. Bioelectron. 25(2), 388–394 (2009).
[CrossRef] [PubMed]

Chen, W.

H. Huang, H. Shi, S. Feng, W. Chen, Y. Yu, D. Lin, R. Chen, “Confocal Raman spectroscopic analysis of the cytotoxic response to cisplatin in nasopharyngeal carcinoma cells,” Anal. Methods 5(1), 260–266 (2012).
[CrossRef]

Cheng, M.

J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
[CrossRef] [PubMed]

J. Lin, R. Chen, S. Feng, Y. Li, Z. Huang, S. Xie, Y. Yu, M. Cheng, H. Zeng, “Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy,” Biosens. Bioelectron. 25(2), 388–394 (2009).
[CrossRef] [PubMed]

Choi, J. W.

W. A. El-Said, T. H. Kim, H. C. Kim, J. W. Choi, “Analysis of intracellular state based on controlled 3D nanostructures mediated surface enhanced Raman scattering,” PLoS ONE 6(2), e15836 (2011).
[CrossRef] [PubMed]

Clarke, C.

A. D. Meade, C. Clarke, F. Draux, G. D. Sockalingum, M. Manfait, F. M. Lyng, H. J. Byrne, “Studies of chemical fixation effects in human cell lines using Raman microspectroscopy,” Anal. Bioanal. Chem. 396(5), 1781–1791 (2010).
[CrossRef] [PubMed]

Coluccio, M. L.

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

Daigrepont, M. C.

H. N. Yehia, R. K. Draper, C. Mikoryak, E. K. Walker, P. Bajaj, I. H. Musselman, M. C. Daigrepont, G. R. Dieckmann, P. Pantano, “Single-walled carbon nanotube interactions with HeLa cells,” J. Nanobiotechnology 5(1), 8 (2007).
[CrossRef] [PubMed]

Das, G.

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

Dasari, R. R.

I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
[CrossRef] [PubMed]

J. W. Kang, N. Lue, C. R. Kong, I. Barman, N. C. Dingari, S. J. Goldfless, J. C. Niles, R. R. Dasari, M. S. Feld, “Combined confocal Raman and quantitative phase microscopy system for biomedical diagnosis,” Biomed. Opt. Express 2(9), 2484–2492 (2011).
[CrossRef] [PubMed]

Day, P. J.

M. M. Mariani, P. J. Day, V. Deckert, “Applications of modern micro-Raman spectroscopy for cell analyses,” Integr Biol (Camb) 2(2-3), 94–101 (2010).
[CrossRef] [PubMed]

De Angelisand, F.

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

De Gelder, J.

J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens, “Reference database of Raman spectra of biological molecules,” J. Raman Spectrosc. 38(9), 1133–1147 (2007).
[CrossRef]

De Gussem, K.

J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens, “Reference database of Raman spectra of biological molecules,” J. Raman Spectrosc. 38(9), 1133–1147 (2007).
[CrossRef]

Deckert, V.

M. M. Mariani, P. J. Day, V. Deckert, “Applications of modern micro-Raman spectroscopy for cell analyses,” Integr Biol (Camb) 2(2-3), 94–101 (2010).
[CrossRef] [PubMed]

Di Fabrizio, E.

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

Dieckmann, G. R.

H. N. Yehia, R. K. Draper, C. Mikoryak, E. K. Walker, P. Bajaj, I. H. Musselman, M. C. Daigrepont, G. R. Dieckmann, P. Pantano, “Single-walled carbon nanotube interactions with HeLa cells,” J. Nanobiotechnology 5(1), 8 (2007).
[CrossRef] [PubMed]

Dingari, N. C.

I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
[CrossRef] [PubMed]

J. W. Kang, N. Lue, C. R. Kong, I. Barman, N. C. Dingari, S. J. Goldfless, J. C. Niles, R. R. Dasari, M. S. Feld, “Combined confocal Raman and quantitative phase microscopy system for biomedical diagnosis,” Biomed. Opt. Express 2(9), 2484–2492 (2011).
[CrossRef] [PubMed]

Dochow, S.

S. Dochow, C. Krafft, U. Neugebauer, T. Bocklitz, T. Henkel, G. Mayer, J. Albert, J. Popp, “Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environments,” Lab Chip 11(8), 1484–1490 (2011).
[CrossRef] [PubMed]

Draper, R. K.

H. N. Yehia, R. K. Draper, C. Mikoryak, E. K. Walker, P. Bajaj, I. H. Musselman, M. C. Daigrepont, G. R. Dieckmann, P. Pantano, “Single-walled carbon nanotube interactions with HeLa cells,” J. Nanobiotechnology 5(1), 8 (2007).
[CrossRef] [PubMed]

Draux, F.

A. D. Meade, C. Clarke, F. Draux, G. D. Sockalingum, M. Manfait, F. M. Lyng, H. J. Byrne, “Studies of chemical fixation effects in human cell lines using Raman microspectroscopy,” Anal. Bioanal. Chem. 396(5), 1781–1791 (2010).
[CrossRef] [PubMed]

Duan, X.

Dyer, C.

I. Notingher, C. Green, C. Dyer, E. Perkins, N. Hopkins, C. Lindsay, L. L. Hench, “Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy,” J. R. Soc. Interface 1(1), 79–90 (2004).
[CrossRef] [PubMed]

Elder, M. J.

B. J. Vote, M. J. Elder, “Cyanoacrylate glue for corneal perforations: a description of a surgical technique and a review of the literature,” Clin. Experiment. Ophthalmol. 28(6), 437–442 (2000).
[CrossRef] [PubMed]

El-Said, W. A.

W. A. El-Said, T. H. Kim, H. C. Kim, J. W. Choi, “Analysis of intracellular state based on controlled 3D nanostructures mediated surface enhanced Raman scattering,” PLoS ONE 6(2), e15836 (2011).
[CrossRef] [PubMed]

Emmerling, F.

J. Schenk, L. Tröbs, F. Emmerling, J. Kneipp, U. Panne, M. Albrecht, “Simultaneous UV/Vis spectroscopy and surface enhanced Raman scattering of nanoparticle formation and aggregation in levitated droplets,” Anal. Methods 4(5), 1252–1258 (2012).
[CrossRef]

Feld, M. S.

Feng, S.

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

H. Huang, H. Shi, S. Feng, W. Chen, Y. Yu, D. Lin, R. Chen, “Confocal Raman spectroscopic analysis of the cytotoxic response to cisplatin in nasopharyngeal carcinoma cells,” Anal. Methods 5(1), 260–266 (2012).
[CrossRef]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[CrossRef] [PubMed]

Y. Yu, J. Lin, Y. Wu, S. Feng, Y. Li, Z. Huang, R. Chen, H. Zeng, “Optimizing electroporation assisted silver nanoparticle delivery into living C666 cells for surface-enhanced Raman spectroscopy,” Spectroscopy 25(1), 13–21 (2011).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
[CrossRef] [PubMed]

J. Lin, R. Chen, S. Feng, Y. Li, Z. Huang, S. Xie, Y. Yu, M. Cheng, H. Zeng, “Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy,” Biosens. Bioelectron. 25(2), 388–394 (2009).
[CrossRef] [PubMed]

Fitzmaurice, M.

I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
[CrossRef] [PubMed]

Fotakis, G.

G. Fotakis, J. A. Timbrell, “In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride,” Toxicol. Lett. 160(2), 171–177 (2006).
[CrossRef] [PubMed]

Fregola, A.

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

Fritch, J.

Galindo, L. H.

I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
[CrossRef] [PubMed]

Gentile, F.

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

Ghanate, A. D.

A. D. Ghanate, S. Kothiwale, S. P. Singh, D. Bertrand, C. M. Krishna, “Comparative evaluation of spectroscopic models using different multivariate statistical tools in a multicancer scenario,” J. Biomed. Opt. 16(2), 025003 (2011).
[CrossRef] [PubMed]

Goldfless, S. J.

Gottsch, J. D.

A. B. Leahey, J. D. Gottsch, W. J. Stark, “Clinical experience with N-butyl cyanoacrylate (Nexacryl) tissue adhesive,” Ophthalmology 100(2), 173–180 (1993).
[PubMed]

Green, C.

I. Notingher, C. Green, C. Dyer, E. Perkins, N. Hopkins, C. Lindsay, L. L. Hench, “Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy,” J. R. Soc. Interface 1(1), 79–90 (2004).
[CrossRef] [PubMed]

Guo, Z.

L. Chen, X. X. Han, Z. Guo, X. Wang, W. Ruan, W. Song, B. Zhao, Y. Ozaki, “Biomagnetic glass beads for protein separation and detection based on surface-enhanced Raman scattering,” Anal. Methods 4(6), 1643–1647 (2012).
[CrossRef]

Han, X. X.

L. Chen, X. X. Han, Z. Guo, X. Wang, W. Ruan, W. Song, B. Zhao, Y. Ozaki, “Biomagnetic glass beads for protein separation and detection based on surface-enhanced Raman scattering,” Anal. Methods 4(6), 1643–1647 (2012).
[CrossRef]

Hench, L. L.

C. A. Owen, J. Selvakumaran, I. Notingher, G. Jell, L. L. Hench, M. M. Stevens, “In vitro toxicology evaluation of pharmaceuticals using Raman micro-spectroscopy,” J. Cell. Biochem. 99(1), 178–186 (2006).
[CrossRef] [PubMed]

I. Notingher, C. Green, C. Dyer, E. Perkins, N. Hopkins, C. Lindsay, L. L. Hench, “Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy,” J. R. Soc. Interface 1(1), 79–90 (2004).
[CrossRef] [PubMed]

I. Notingher, J. Selvakumaran, L. L. Hench, “New detection system for toxic agents based on continuous spectroscopic monitoring of living cells,” Biosens. Bioelectron. 20(4), 780–789 (2004).
[CrossRef] [PubMed]

Henkel, T.

S. Dochow, C. Krafft, U. Neugebauer, T. Bocklitz, T. Henkel, G. Mayer, J. Albert, J. Popp, “Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environments,” Lab Chip 11(8), 1484–1490 (2011).
[CrossRef] [PubMed]

Ho, K. Y.

M. S. Bergholt, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, J. B. Y. So, A. Shabbir, Z. Huang, “Fiber-optic Raman spectroscopy probes gastric carcinogenesis in vivo at endoscopy,” J Biophotonics 6(1), 49–59 (2013).
[CrossRef] [PubMed]

Hopkins, N.

I. Notingher, C. Green, C. Dyer, E. Perkins, N. Hopkins, C. Lindsay, L. L. Hench, “Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy,” J. R. Soc. Interface 1(1), 79–90 (2004).
[CrossRef] [PubMed]

Huang, H.

H. Huang, H. Shi, S. Feng, W. Chen, Y. Yu, D. Lin, R. Chen, “Confocal Raman spectroscopic analysis of the cytotoxic response to cisplatin in nasopharyngeal carcinoma cells,” Anal. Methods 5(1), 260–266 (2012).
[CrossRef]

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

Huang, Z.

M. S. Bergholt, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, J. B. Y. So, A. Shabbir, Z. Huang, “Fiber-optic Raman spectroscopy probes gastric carcinogenesis in vivo at endoscopy,” J Biophotonics 6(1), 49–59 (2013).
[CrossRef] [PubMed]

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
[CrossRef] [PubMed]

Y. Yu, J. Lin, Y. Wu, S. Feng, Y. Li, Z. Huang, R. Chen, H. Zeng, “Optimizing electroporation assisted silver nanoparticle delivery into living C666 cells for surface-enhanced Raman spectroscopy,” Spectroscopy 25(1), 13–21 (2011).
[CrossRef]

J. Lin, R. Chen, S. Feng, Y. Li, Z. Huang, S. Xie, Y. Yu, M. Cheng, H. Zeng, “Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy,” Biosens. Bioelectron. 25(2), 388–394 (2009).
[CrossRef] [PubMed]

Huser, T.

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[CrossRef] [PubMed]

Ihara, K.

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[CrossRef] [PubMed]

Jell, G.

C. A. Owen, J. Selvakumaran, I. Notingher, G. Jell, L. L. Hench, M. M. Stevens, “In vitro toxicology evaluation of pharmaceuticals using Raman micro-spectroscopy,” J. Cell. Biochem. 99(1), 178–186 (2006).
[CrossRef] [PubMed]

Jirasek, A.

Kang, J. W.

Kedjarune, U.

P. A. Leggat, D. R. Smith, U. Kedjarune, “Surgical applications of cyanoacrylate adhesives: a review of toxicity,” ANZ J. Surg. 77(4), 209–213 (2007).
[CrossRef] [PubMed]

Kim, H. C.

W. A. El-Said, T. H. Kim, H. C. Kim, J. W. Choi, “Analysis of intracellular state based on controlled 3D nanostructures mediated surface enhanced Raman scattering,” PLoS ONE 6(2), e15836 (2011).
[CrossRef] [PubMed]

Kim, T. H.

W. A. El-Said, T. H. Kim, H. C. Kim, J. W. Choi, “Analysis of intracellular state based on controlled 3D nanostructures mediated surface enhanced Raman scattering,” PLoS ONE 6(2), e15836 (2011).
[CrossRef] [PubMed]

Klein, N.

I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
[CrossRef] [PubMed]

Kneipp, J.

J. Schenk, L. Tröbs, F. Emmerling, J. Kneipp, U. Panne, M. Albrecht, “Simultaneous UV/Vis spectroscopy and surface enhanced Raman scattering of nanoparticle formation and aggregation in levitated droplets,” Anal. Methods 4(5), 1252–1258 (2012).
[CrossRef]

Kong, C. R.

Kothiwale, S.

A. D. Ghanate, S. Kothiwale, S. P. Singh, D. Bertrand, C. M. Krishna, “Comparative evaluation of spectroscopic models using different multivariate statistical tools in a multicancer scenario,” J. Biomed. Opt. 16(2), 025003 (2011).
[CrossRef] [PubMed]

Krafft, C.

S. Dochow, C. Krafft, U. Neugebauer, T. Bocklitz, T. Henkel, G. Mayer, J. Albert, J. Popp, “Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environments,” Lab Chip 11(8), 1484–1490 (2011).
[CrossRef] [PubMed]

Krishna, C. M.

A. D. Ghanate, S. Kothiwale, S. P. Singh, D. Bertrand, C. M. Krishna, “Comparative evaluation of spectroscopic models using different multivariate statistical tools in a multicancer scenario,” J. Biomed. Opt. 16(2), 025003 (2011).
[CrossRef] [PubMed]

Krol, D. M.

Lane, S. M.

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[CrossRef] [PubMed]

Leahey, A. B.

A. B. Leahey, J. D. Gottsch, W. J. Stark, “Clinical experience with N-butyl cyanoacrylate (Nexacryl) tissue adhesive,” Ophthalmology 100(2), 173–180 (1993).
[PubMed]

Leggat, P. A.

P. A. Leggat, D. R. Smith, U. Kedjarune, “Surgical applications of cyanoacrylate adhesives: a review of toxicity,” ANZ J. Surg. 77(4), 209–213 (2007).
[CrossRef] [PubMed]

Li, B.

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

Li, C.

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

Li, Y.

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

Y. Yu, J. Lin, Y. Wu, S. Feng, Y. Li, Z. Huang, R. Chen, H. Zeng, “Optimizing electroporation assisted silver nanoparticle delivery into living C666 cells for surface-enhanced Raman spectroscopy,” Spectroscopy 25(1), 13–21 (2011).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
[CrossRef] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[CrossRef] [PubMed]

J. Lin, R. Chen, S. Feng, Y. Li, Z. Huang, S. Xie, Y. Yu, M. Cheng, H. Zeng, “Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy,” Biosens. Bioelectron. 25(2), 388–394 (2009).
[CrossRef] [PubMed]

Liberale, C.

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

Lin, D.

H. Huang, H. Shi, S. Feng, W. Chen, Y. Yu, D. Lin, R. Chen, “Confocal Raman spectroscopic analysis of the cytotoxic response to cisplatin in nasopharyngeal carcinoma cells,” Anal. Methods 5(1), 260–266 (2012).
[CrossRef]

Lin, J.

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

Y. Yu, J. Lin, Y. Wu, S. Feng, Y. Li, Z. Huang, R. Chen, H. Zeng, “Optimizing electroporation assisted silver nanoparticle delivery into living C666 cells for surface-enhanced Raman spectroscopy,” Spectroscopy 25(1), 13–21 (2011).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
[CrossRef] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[CrossRef] [PubMed]

J. Lin, R. Chen, S. Feng, Y. Li, Z. Huang, S. Xie, Y. Yu, M. Cheng, H. Zeng, “Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy,” Biosens. Bioelectron. 25(2), 388–394 (2009).
[CrossRef] [PubMed]

Lin, S.

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

Lindsay, C.

I. Notingher, C. Green, C. Dyer, E. Perkins, N. Hopkins, C. Lindsay, L. L. Hench, “Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy,” J. R. Soc. Interface 1(1), 79–90 (2004).
[CrossRef] [PubMed]

Liu, W.

I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
[CrossRef] [PubMed]

Lochmann, D.

J. Weyermann, D. Lochmann, A. Zimmer, “A practical note on the use of cytotoxicity assays,” Int. J. Pharm. 288(2), 369–376 (2005).
[CrossRef] [PubMed]

Lue, N.

Lum, J.

Lyng, F. M.

A. D. Meade, C. Clarke, F. Draux, G. D. Sockalingum, M. Manfait, F. M. Lyng, H. J. Byrne, “Studies of chemical fixation effects in human cell lines using Raman microspectroscopy,” Anal. Bioanal. Chem. 396(5), 1781–1791 (2010).
[CrossRef] [PubMed]

Mahadevan-Jansen, A.

A. J. Makowski, C. A. Patil, A. Mahadevan-Jansen, J. S. Nyman, “Polarization control of Raman spectroscopy optimizes the assessment of bone tissue,” J. Biomed. Opt. 18(5), 055005 (2013).
[CrossRef] [PubMed]

Makowski, A. J.

A. J. Makowski, C. A. Patil, A. Mahadevan-Jansen, J. S. Nyman, “Polarization control of Raman spectroscopy optimizes the assessment of bone tissue,” J. Biomed. Opt. 18(5), 055005 (2013).
[CrossRef] [PubMed]

Malara, N.

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

Manfait, M.

A. D. Meade, C. Clarke, F. Draux, G. D. Sockalingum, M. Manfait, F. M. Lyng, H. J. Byrne, “Studies of chemical fixation effects in human cell lines using Raman microspectroscopy,” Anal. Bioanal. Chem. 396(5), 1781–1791 (2010).
[CrossRef] [PubMed]

Mariani, M. M.

M. M. Mariani, P. J. Day, V. Deckert, “Applications of modern micro-Raman spectroscopy for cell analyses,” Integr Biol (Camb) 2(2-3), 94–101 (2010).
[CrossRef] [PubMed]

Matthews, Q.

Mayer, G.

S. Dochow, C. Krafft, U. Neugebauer, T. Bocklitz, T. Henkel, G. Mayer, J. Albert, J. Popp, “Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environments,” Lab Chip 11(8), 1484–1490 (2011).
[CrossRef] [PubMed]

McGee, S.

I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
[CrossRef] [PubMed]

Meade, A. D.

A. D. Meade, C. Clarke, F. Draux, G. D. Sockalingum, M. Manfait, F. M. Lyng, H. J. Byrne, “Studies of chemical fixation effects in human cell lines using Raman microspectroscopy,” Anal. Bioanal. Chem. 396(5), 1781–1791 (2010).
[CrossRef] [PubMed]

Mikoryak, C.

H. N. Yehia, R. K. Draper, C. Mikoryak, E. K. Walker, P. Bajaj, I. H. Musselman, M. C. Daigrepont, G. R. Dieckmann, P. Pantano, “Single-walled carbon nanotube interactions with HeLa cells,” J. Nanobiotechnology 5(1), 8 (2007).
[CrossRef] [PubMed]

Moens, L.

J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens, “Reference database of Raman spectra of biological molecules,” J. Raman Spectrosc. 38(9), 1133–1147 (2007).
[CrossRef]

Moritz, T. J.

Musselman, I. H.

H. N. Yehia, R. K. Draper, C. Mikoryak, E. K. Walker, P. Bajaj, I. H. Musselman, M. C. Daigrepont, G. R. Dieckmann, P. Pantano, “Single-walled carbon nanotube interactions with HeLa cells,” J. Nanobiotechnology 5(1), 8 (2007).
[CrossRef] [PubMed]

Neugebauer, U.

S. Dochow, C. Krafft, U. Neugebauer, T. Bocklitz, T. Henkel, G. Mayer, J. Albert, J. Popp, “Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environments,” Lab Chip 11(8), 1484–1490 (2011).
[CrossRef] [PubMed]

Niles, J. C.

Notingher, I.

C. A. Owen, J. Selvakumaran, I. Notingher, G. Jell, L. L. Hench, M. M. Stevens, “In vitro toxicology evaluation of pharmaceuticals using Raman micro-spectroscopy,” J. Cell. Biochem. 99(1), 178–186 (2006).
[CrossRef] [PubMed]

I. Notingher, C. Green, C. Dyer, E. Perkins, N. Hopkins, C. Lindsay, L. L. Hench, “Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy,” J. R. Soc. Interface 1(1), 79–90 (2004).
[CrossRef] [PubMed]

I. Notingher, J. Selvakumaran, L. L. Hench, “New detection system for toxic agents based on continuous spectroscopic monitoring of living cells,” Biosens. Bioelectron. 20(4), 780–789 (2004).
[CrossRef] [PubMed]

Nyman, J. S.

A. J. Makowski, C. A. Patil, A. Mahadevan-Jansen, J. S. Nyman, “Polarization control of Raman spectroscopy optimizes the assessment of bone tissue,” J. Biomed. Opt. 18(5), 055005 (2013).
[CrossRef] [PubMed]

Owen, C. A.

C. A. Owen, J. Selvakumaran, I. Notingher, G. Jell, L. L. Hench, M. M. Stevens, “In vitro toxicology evaluation of pharmaceuticals using Raman micro-spectroscopy,” J. Cell. Biochem. 99(1), 178–186 (2006).
[CrossRef] [PubMed]

Ozaki, Y.

L. Chen, X. X. Han, Z. Guo, X. Wang, W. Ruan, W. Song, B. Zhao, Y. Ozaki, “Biomagnetic glass beads for protein separation and detection based on surface-enhanced Raman scattering,” Anal. Methods 4(6), 1643–1647 (2012).
[CrossRef]

Pan, J.

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[CrossRef] [PubMed]

J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
[CrossRef] [PubMed]

Panne, U.

J. Schenk, L. Tröbs, F. Emmerling, J. Kneipp, U. Panne, M. Albrecht, “Simultaneous UV/Vis spectroscopy and surface enhanced Raman scattering of nanoparticle formation and aggregation in levitated droplets,” Anal. Methods 4(5), 1252–1258 (2012).
[CrossRef]

Pantano, P.

H. N. Yehia, R. K. Draper, C. Mikoryak, E. K. Walker, P. Bajaj, I. H. Musselman, M. C. Daigrepont, G. R. Dieckmann, P. Pantano, “Single-walled carbon nanotube interactions with HeLa cells,” J. Nanobiotechnology 5(1), 8 (2007).
[CrossRef] [PubMed]

Patil, C. A.

A. J. Makowski, C. A. Patil, A. Mahadevan-Jansen, J. S. Nyman, “Polarization control of Raman spectroscopy optimizes the assessment of bone tissue,” J. Biomed. Opt. 18(5), 055005 (2013).
[CrossRef] [PubMed]

Perkins, E.

I. Notingher, C. Green, C. Dyer, E. Perkins, N. Hopkins, C. Lindsay, L. L. Hench, “Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy,” J. R. Soc. Interface 1(1), 79–90 (2004).
[CrossRef] [PubMed]

Perozziello, G.

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

Plecha, D.

I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
[CrossRef] [PubMed]

Popp, J.

S. Dochow, C. Krafft, U. Neugebauer, T. Bocklitz, T. Henkel, G. Mayer, J. Albert, J. Popp, “Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environments,” Lab Chip 11(8), 1484–1490 (2011).
[CrossRef] [PubMed]

Puntes, V.

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

Ruan, W.

L. Chen, X. X. Han, Z. Guo, X. Wang, W. Ruan, W. Song, B. Zhao, Y. Ozaki, “Biomagnetic glass beads for protein separation and detection based on surface-enhanced Raman scattering,” Anal. Methods 4(6), 1643–1647 (2012).
[CrossRef]

Saha, A.

I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
[CrossRef] [PubMed]

Schenk, J.

J. Schenk, L. Tröbs, F. Emmerling, J. Kneipp, U. Panne, M. Albrecht, “Simultaneous UV/Vis spectroscopy and surface enhanced Raman scattering of nanoparticle formation and aggregation in levitated droplets,” Anal. Methods 4(5), 1252–1258 (2012).
[CrossRef]

Selvakumaran, J.

C. A. Owen, J. Selvakumaran, I. Notingher, G. Jell, L. L. Hench, M. M. Stevens, “In vitro toxicology evaluation of pharmaceuticals using Raman micro-spectroscopy,” J. Cell. Biochem. 99(1), 178–186 (2006).
[CrossRef] [PubMed]

I. Notingher, J. Selvakumaran, L. L. Hench, “New detection system for toxic agents based on continuous spectroscopic monitoring of living cells,” Biosens. Bioelectron. 20(4), 780–789 (2004).
[CrossRef] [PubMed]

Shabbir, A.

M. S. Bergholt, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, J. B. Y. So, A. Shabbir, Z. Huang, “Fiber-optic Raman spectroscopy probes gastric carcinogenesis in vivo at endoscopy,” J Biophotonics 6(1), 49–59 (2013).
[CrossRef] [PubMed]

Shi, H.

H. Huang, H. Shi, S. Feng, W. Chen, Y. Yu, D. Lin, R. Chen, “Confocal Raman spectroscopic analysis of the cytotoxic response to cisplatin in nasopharyngeal carcinoma cells,” Anal. Methods 5(1), 260–266 (2012).
[CrossRef]

Singh, S. P.

A. D. Ghanate, S. Kothiwale, S. P. Singh, D. Bertrand, C. M. Krishna, “Comparative evaluation of spectroscopic models using different multivariate statistical tools in a multicancer scenario,” J. Biomed. Opt. 16(2), 025003 (2011).
[CrossRef] [PubMed]

Smith, D. R.

P. A. Leggat, D. R. Smith, U. Kedjarune, “Surgical applications of cyanoacrylate adhesives: a review of toxicity,” ANZ J. Surg. 77(4), 209–213 (2007).
[CrossRef] [PubMed]

So, J. B. Y.

M. S. Bergholt, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, J. B. Y. So, A. Shabbir, Z. Huang, “Fiber-optic Raman spectroscopy probes gastric carcinogenesis in vivo at endoscopy,” J Biophotonics 6(1), 49–59 (2013).
[CrossRef] [PubMed]

Sockalingum, G. D.

A. D. Meade, C. Clarke, F. Draux, G. D. Sockalingum, M. Manfait, F. M. Lyng, H. J. Byrne, “Studies of chemical fixation effects in human cell lines using Raman microspectroscopy,” Anal. Bioanal. Chem. 396(5), 1781–1791 (2010).
[CrossRef] [PubMed]

Song, W.

L. Chen, X. X. Han, Z. Guo, X. Wang, W. Ruan, W. Song, B. Zhao, Y. Ozaki, “Biomagnetic glass beads for protein separation and detection based on surface-enhanced Raman scattering,” Anal. Methods 4(6), 1643–1647 (2012).
[CrossRef]

Stark, W. J.

A. B. Leahey, J. D. Gottsch, W. J. Stark, “Clinical experience with N-butyl cyanoacrylate (Nexacryl) tissue adhesive,” Ophthalmology 100(2), 173–180 (1993).
[PubMed]

Stevens, M. M.

C. A. Owen, J. Selvakumaran, I. Notingher, G. Jell, L. L. Hench, M. M. Stevens, “In vitro toxicology evaluation of pharmaceuticals using Raman micro-spectroscopy,” J. Cell. Biochem. 99(1), 178–186 (2006).
[CrossRef] [PubMed]

Su, Y.

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

Sun, L.

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

Taylor, D. S.

T. J. Moritz, D. S. Taylor, D. M. Krol, J. Fritch, J. W. Chan, “Detection of doxorubicin-induced apoptosis of leukemic T-lymphocytes by laser tweezers Raman spectroscopy,” Biomed. Opt. Express 1(4), 1138–1147 (2010).
[CrossRef] [PubMed]

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[CrossRef] [PubMed]

Teh, M.

M. S. Bergholt, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, J. B. Y. So, A. Shabbir, Z. Huang, “Fiber-optic Raman spectroscopy probes gastric carcinogenesis in vivo at endoscopy,” J Biophotonics 6(1), 49–59 (2013).
[CrossRef] [PubMed]

Timbrell, J. A.

G. Fotakis, J. A. Timbrell, “In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride,” Toxicol. Lett. 160(2), 171–177 (2006).
[CrossRef] [PubMed]

Tröbs, L.

J. Schenk, L. Tröbs, F. Emmerling, J. Kneipp, U. Panne, M. Albrecht, “Simultaneous UV/Vis spectroscopy and surface enhanced Raman scattering of nanoparticle formation and aggregation in levitated droplets,” Anal. Methods 4(5), 1252–1258 (2012).
[CrossRef]

Vandenabeele, P.

J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens, “Reference database of Raman spectra of biological molecules,” J. Raman Spectrosc. 38(9), 1133–1147 (2007).
[CrossRef]

Vote, B. J.

B. J. Vote, M. J. Elder, “Cyanoacrylate glue for corneal perforations: a description of a surgical technique and a review of the literature,” Clin. Experiment. Ophthalmol. 28(6), 437–442 (2000).
[CrossRef] [PubMed]

Walker, E. K.

H. N. Yehia, R. K. Draper, C. Mikoryak, E. K. Walker, P. Bajaj, I. H. Musselman, M. C. Daigrepont, G. R. Dieckmann, P. Pantano, “Single-walled carbon nanotube interactions with HeLa cells,” J. Nanobiotechnology 5(1), 8 (2007).
[CrossRef] [PubMed]

Wang, X.

L. Chen, X. X. Han, Z. Guo, X. Wang, W. Ruan, W. Song, B. Zhao, Y. Ozaki, “Biomagnetic glass beads for protein separation and detection based on surface-enhanced Raman scattering,” Anal. Methods 4(6), 1643–1647 (2012).
[CrossRef]

Weyermann, J.

J. Weyermann, D. Lochmann, A. Zimmer, “A practical note on the use of cytotoxicity assays,” Int. J. Pharm. 288(2), 369–376 (2005).
[CrossRef] [PubMed]

Wu, Y.

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[CrossRef] [PubMed]

Y. Yu, J. Lin, Y. Wu, S. Feng, Y. Li, Z. Huang, R. Chen, H. Zeng, “Optimizing electroporation assisted silver nanoparticle delivery into living C666 cells for surface-enhanced Raman spectroscopy,” Spectroscopy 25(1), 13–21 (2011).
[CrossRef]

Xie, S.

J. Lin, R. Chen, S. Feng, Y. Li, Z. Huang, S. Xie, Y. Yu, M. Cheng, H. Zeng, “Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy,” Biosens. Bioelectron. 25(2), 388–394 (2009).
[CrossRef] [PubMed]

Yehia, H. N.

H. N. Yehia, R. K. Draper, C. Mikoryak, E. K. Walker, P. Bajaj, I. H. Musselman, M. C. Daigrepont, G. R. Dieckmann, P. Pantano, “Single-walled carbon nanotube interactions with HeLa cells,” J. Nanobiotechnology 5(1), 8 (2007).
[CrossRef] [PubMed]

Yeoh, K. G.

M. S. Bergholt, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, J. B. Y. So, A. Shabbir, Z. Huang, “Fiber-optic Raman spectroscopy probes gastric carcinogenesis in vivo at endoscopy,” J Biophotonics 6(1), 49–59 (2013).
[CrossRef] [PubMed]

Yetter, A. B.

S. K. Bhatia, A. B. Yetter, “Correlation of visual in vitro cytotoxicity ratings of biomaterials with quantitative in vitro cell viability measurements,” Cell Biol. Toxicol. 24(4), 315–319 (2008).
[CrossRef] [PubMed]

Yu, Y.

H. Huang, H. Shi, S. Feng, W. Chen, Y. Yu, D. Lin, R. Chen, “Confocal Raman spectroscopic analysis of the cytotoxic response to cisplatin in nasopharyngeal carcinoma cells,” Anal. Methods 5(1), 260–266 (2012).
[CrossRef]

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

Y. Yu, J. Lin, Y. Wu, S. Feng, Y. Li, Z. Huang, R. Chen, H. Zeng, “Optimizing electroporation assisted silver nanoparticle delivery into living C666 cells for surface-enhanced Raman spectroscopy,” Spectroscopy 25(1), 13–21 (2011).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
[CrossRef] [PubMed]

J. Lin, R. Chen, S. Feng, Y. Li, Z. Huang, S. Xie, Y. Yu, M. Cheng, H. Zeng, “Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy,” Biosens. Bioelectron. 25(2), 388–394 (2009).
[CrossRef] [PubMed]

Zalut, T.

J. S. Applebaum, T. Zalut, D. Applebaum, “The use of tissue adhesion for traumatic laceration repair in the emergency department,” Ann. Emerg. Med. 22(7), 1190–1192 (1993).
[CrossRef] [PubMed]

Zeng, H.

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

Y. Yu, J. Lin, Y. Wu, S. Feng, Y. Li, Z. Huang, R. Chen, H. Zeng, “Optimizing electroporation assisted silver nanoparticle delivery into living C666 cells for surface-enhanced Raman spectroscopy,” Spectroscopy 25(1), 13–21 (2011).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
[CrossRef] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[CrossRef] [PubMed]

J. Lin, R. Chen, S. Feng, Y. Li, Z. Huang, S. Xie, Y. Yu, M. Cheng, H. Zeng, “Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy,” Biosens. Bioelectron. 25(2), 388–394 (2009).
[CrossRef] [PubMed]

Zhao, B.

L. Chen, X. X. Han, Z. Guo, X. Wang, W. Ruan, W. Song, B. Zhao, Y. Ozaki, “Biomagnetic glass beads for protein separation and detection based on surface-enhanced Raman scattering,” Anal. Methods 4(6), 1643–1647 (2012).
[CrossRef]

Zheng, W.

M. S. Bergholt, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, J. B. Y. So, A. Shabbir, Z. Huang, “Fiber-optic Raman spectroscopy probes gastric carcinogenesis in vivo at endoscopy,” J Biophotonics 6(1), 49–59 (2013).
[CrossRef] [PubMed]

Zimmer, A.

J. Weyermann, D. Lochmann, A. Zimmer, “A practical note on the use of cytotoxicity assays,” Int. J. Pharm. 288(2), 369–376 (2005).
[CrossRef] [PubMed]

Zwerdling, T.

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[CrossRef] [PubMed]

Anal. Bioanal. Chem.

A. D. Meade, C. Clarke, F. Draux, G. D. Sockalingum, M. Manfait, F. M. Lyng, H. J. Byrne, “Studies of chemical fixation effects in human cell lines using Raman microspectroscopy,” Anal. Bioanal. Chem. 396(5), 1781–1791 (2010).
[CrossRef] [PubMed]

Anal. Methods

H. Huang, H. Shi, S. Feng, W. Chen, Y. Yu, D. Lin, R. Chen, “Confocal Raman spectroscopic analysis of the cytotoxic response to cisplatin in nasopharyngeal carcinoma cells,” Anal. Methods 5(1), 260–266 (2012).
[CrossRef]

J. Schenk, L. Tröbs, F. Emmerling, J. Kneipp, U. Panne, M. Albrecht, “Simultaneous UV/Vis spectroscopy and surface enhanced Raman scattering of nanoparticle formation and aggregation in levitated droplets,” Anal. Methods 4(5), 1252–1258 (2012).
[CrossRef]

L. Chen, X. X. Han, Z. Guo, X. Wang, W. Ruan, W. Song, B. Zhao, Y. Ozaki, “Biomagnetic glass beads for protein separation and detection based on surface-enhanced Raman scattering,” Anal. Methods 4(6), 1643–1647 (2012).
[CrossRef]

Analyst (Lond.)

P. Candeloro Luca Tirinato, N. Malara, A. Fregola, E. Casals, V. Puntes, G. Perozziello, F. Gentile, M. L. Coluccio, G. Das, C. Liberale, F. De Angelisand, E. Di Fabrizio, “Nanoparticle microinjection and Raman spectroscopy as tools for nanotoxicology studies,” Analyst (Lond.) 136(21), 4402–4408 (2011).

Ann. Emerg. Med.

J. S. Applebaum, T. Zalut, D. Applebaum, “The use of tissue adhesion for traumatic laceration repair in the emergency department,” Ann. Emerg. Med. 22(7), 1190–1192 (1993).
[CrossRef] [PubMed]

ANZ J. Surg.

P. A. Leggat, D. R. Smith, U. Kedjarune, “Surgical applications of cyanoacrylate adhesives: a review of toxicity,” ANZ J. Surg. 77(4), 209–213 (2007).
[CrossRef] [PubMed]

Appl. Spectrosc.

Biomed. Opt. Express

Biophys. J.

J. W. Chan, D. S. Taylor, T. Zwerdling, S. M. Lane, K. Ihara, T. Huser, “Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells,” Biophys. J. 90(2), 648–656 (2006).
[CrossRef] [PubMed]

Biosens. Bioelectron.

J. Lin, R. Chen, S. Feng, Y. Li, Z. Huang, S. Xie, Y. Yu, M. Cheng, H. Zeng, “Rapid delivery of silver nanoparticles into living cells by electroporation for surface-enhanced Raman spectroscopy,” Biosens. Bioelectron. 25(2), 388–394 (2009).
[CrossRef] [PubMed]

I. Notingher, J. Selvakumaran, L. L. Hench, “New detection system for toxic agents based on continuous spectroscopic monitoring of living cells,” Biosens. Bioelectron. 20(4), 780–789 (2004).
[CrossRef] [PubMed]

S. Feng, R. Chen, J. Lin, J. Pan, Y. Wu, Y. Li, J. Chen, H. Zeng, “Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light,” Biosens. Bioelectron. 26(7), 3167–3174 (2011).
[CrossRef] [PubMed]

Cancer Res.

I. Barman, N. C. Dingari, A. Saha, S. McGee, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, M. Fitzmaurice, “Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy,” Cancer Res. 73(11), 3206–3215 (2013).
[CrossRef] [PubMed]

Cell Biol. Toxicol.

S. K. Bhatia, A. B. Yetter, “Correlation of visual in vitro cytotoxicity ratings of biomaterials with quantitative in vitro cell viability measurements,” Cell Biol. Toxicol. 24(4), 315–319 (2008).
[CrossRef] [PubMed]

Clin. Experiment. Ophthalmol.

B. J. Vote, M. J. Elder, “Cyanoacrylate glue for corneal perforations: a description of a surgical technique and a review of the literature,” Clin. Experiment. Ophthalmol. 28(6), 437–442 (2000).
[CrossRef] [PubMed]

Endod. Dent. Traumatol.

L. P. Blanco, “Lip suture with isobutyl cyanoacrylate,” Endod. Dent. Traumatol. 10(1), 15–18 (1994).
[CrossRef] [PubMed]

Int. J. Pharm.

J. Weyermann, D. Lochmann, A. Zimmer, “A practical note on the use of cytotoxicity assays,” Int. J. Pharm. 288(2), 369–376 (2005).
[CrossRef] [PubMed]

Integr Biol (Camb)

M. M. Mariani, P. J. Day, V. Deckert, “Applications of modern micro-Raman spectroscopy for cell analyses,” Integr Biol (Camb) 2(2-3), 94–101 (2010).
[CrossRef] [PubMed]

J Biophotonics

M. S. Bergholt, W. Zheng, K. Y. Ho, M. Teh, K. G. Yeoh, J. B. Y. So, A. Shabbir, Z. Huang, “Fiber-optic Raman spectroscopy probes gastric carcinogenesis in vivo at endoscopy,” J Biophotonics 6(1), 49–59 (2013).
[CrossRef] [PubMed]

J. Biomed. Opt.

A. D. Ghanate, S. Kothiwale, S. P. Singh, D. Bertrand, C. M. Krishna, “Comparative evaluation of spectroscopic models using different multivariate statistical tools in a multicancer scenario,” J. Biomed. Opt. 16(2), 025003 (2011).
[CrossRef] [PubMed]

A. J. Makowski, C. A. Patil, A. Mahadevan-Jansen, J. S. Nyman, “Polarization control of Raman spectroscopy optimizes the assessment of bone tissue,” J. Biomed. Opt. 18(5), 055005 (2013).
[CrossRef] [PubMed]

J. Cell. Biochem.

C. A. Owen, J. Selvakumaran, I. Notingher, G. Jell, L. L. Hench, M. M. Stevens, “In vitro toxicology evaluation of pharmaceuticals using Raman micro-spectroscopy,” J. Cell. Biochem. 99(1), 178–186 (2006).
[CrossRef] [PubMed]

J. Nanobiotechnology

H. N. Yehia, R. K. Draper, C. Mikoryak, E. K. Walker, P. Bajaj, I. H. Musselman, M. C. Daigrepont, G. R. Dieckmann, P. Pantano, “Single-walled carbon nanotube interactions with HeLa cells,” J. Nanobiotechnology 5(1), 8 (2007).
[CrossRef] [PubMed]

J. R. Soc. Interface

I. Notingher, C. Green, C. Dyer, E. Perkins, N. Hopkins, C. Lindsay, L. L. Hench, “Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy,” J. R. Soc. Interface 1(1), 79–90 (2004).
[CrossRef] [PubMed]

J. Raman Spectrosc.

J. De Gelder, K. De Gussem, P. Vandenabeele, L. Moens, “Reference database of Raman spectra of biological molecules,” J. Raman Spectrosc. 38(9), 1133–1147 (2007).
[CrossRef]

J. Lin, R. Chen, S. Feng, J. Pan, B. Li, G. Chen, S. Lin, C. Li, L. Sun, Z. Huang, H. Zeng, “Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection,” J. Raman Spectrosc. 43(4), 497–502 (2012).
[CrossRef]

Lab Chip

S. Dochow, C. Krafft, U. Neugebauer, T. Bocklitz, T. Henkel, G. Mayer, J. Albert, J. Popp, “Tumour cell identification by means of Raman spectroscopy in combination with optical traps and microfluidic environments,” Lab Chip 11(8), 1484–1490 (2011).
[CrossRef] [PubMed]

Laser Phys. Lett.

J. Lin, Y. Yu, B. Li, H. Huang, S. Lin, C. Li, Y. Su, S. Feng, G. Chen, Y. Li, Z. Huang, H. Zeng, R. Chen, “Electrical pulse – mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy,” Laser Phys. Lett. 9(3), 240–246 (2012).
[CrossRef]

Nanomedicine

J. Lin, R. Chen, S. Feng, J. Pan, Y. Li, G. Chen, M. Cheng, Z. Huang, Y. Yu, H. Zeng, “A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection,” Nanomedicine 7(5), 655–663 (2011).
[CrossRef] [PubMed]

Ophthalmology

A. B. Leahey, J. D. Gottsch, W. J. Stark, “Clinical experience with N-butyl cyanoacrylate (Nexacryl) tissue adhesive,” Ophthalmology 100(2), 173–180 (1993).
[PubMed]

PLoS ONE

W. A. El-Said, T. H. Kim, H. C. Kim, J. W. Choi, “Analysis of intracellular state based on controlled 3D nanostructures mediated surface enhanced Raman scattering,” PLoS ONE 6(2), e15836 (2011).
[CrossRef] [PubMed]

Spectroscopy

Y. Yu, J. Lin, Y. Wu, S. Feng, Y. Li, Z. Huang, R. Chen, H. Zeng, “Optimizing electroporation assisted silver nanoparticle delivery into living C666 cells for surface-enhanced Raman spectroscopy,” Spectroscopy 25(1), 13–21 (2011).
[CrossRef]

Toxicol. Lett.

G. Fotakis, J. A. Timbrell, “In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride,” Toxicol. Lett. 160(2), 171–177 (2006).
[CrossRef] [PubMed]

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Figures (6)

Fig. 1
Fig. 1

Averaged Raman spectra of L929 cells: (a) Control and (b) Dermabond-treated. The spectrum (c) shows the spectral differences of control cells and cells treated with Dermabond tissue adhesive.

Fig. 2
Fig. 2

Relative intensities of the Raman peaks for control cells and cells treated with Dermabond tissue adhesive.

Fig. 3
Fig. 3

Averaged Raman spectra of DNA: (a) Control and (b) Dermabond-treated. The spectrum (c) shows the spectral differences of control DNA and DNA treated with Dermabond tissue adhesive.

Fig. 4
Fig. 4

Relative intensities of the Raman peaks for control DNA and DNA treated with Dermabond tissue adhesive.

Fig. 5
Fig. 5

WST and LIVE/DEAD viability/cytotoxicity assays were used to determine cytotoxicity after Dermabond tissue adhesive treatment. Mouse L929 fibroblasts (1 × 105 cells) were seeded in 12-well plates and treated with Dermabond. After a 24 hr incubation, cytotoxicity was analyzed using the (a) WST assay and (b) LIVE/DEAD viability/cytotoxicity assay.

Fig. 6
Fig. 6

Evaluation of apoptotic cell death in Dermabond tissue adhesive-treated cells by TUNEL assay. The TUNEL assay was performed in (a) negative control, (b) Dermabond-treated L9292 cells and (c) positive control.

Tables (2)

Tables Icon

Table 1 Peak assignment of the Raman spectra of L929 cells

Tables Icon

Table 2 Peak assignment of the Raman spectra of DNA

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