Abstract

We analyze the benefits and problems of in vivo optical coherence tomography (OCT) imaging of the human retina at A-scan rates in excess of 1 MHz, using a 1050 nm Fourier-domain mode-locked (FDML) laser. Different scanning strategies enabled by MHz OCT line rates are investigated, and a simple multi-volume data processing approach is presented. In-vivo OCT of the human ocular fundus is performed at different axial scan rates of up to 6.7 MHz. High quality non-mydriatic retinal imaging over an ultra-wide field is achieved by a combination of several key improvements compared to previous setups. For the FDML laser, long coherence lengths and 72 nm wavelength tuning range are achieved using a chirped fiber Bragg grating in a laser cavity at 419.1 kHz fundamental tuning rate. Very large data sets can be acquired with sustained data transfer from the data acquisition card to host computer memory, enabling high-quality averaging of many frames and of multiple aligned data sets. Three imaging modes are investigated: Alignment and averaging of 24 data sets at 1.68 MHz axial line rate, ultra-dense transverse sampling at 3.35 MHz line rate, and dual-beam imaging with two laser spots on the retina at an effective line rate of 6.7 MHz.

© 2013 OSA

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2013 (6)

A. A. Ellabban, A. Tsujikawa, A. Matsumoto, K. Yamashiro, A. Oishi, S. Ooto, I. Nakata, Y. Akagi-Kurashige, M. Miyake, H. S. Elnahas, T. M. Radwan, K. A. Zaky, and N. Yoshimura, “Three-Dimensional Tomographic Features of Dome-Shaped Macula by Swept-Source Optical Coherence Tomography,” Am. J. Ophthalmol.155(2), 320–328, e2 (2013).
[CrossRef] [PubMed]

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, J. Jiang, J. G. Fujimoto, and A. E. Cable, “High-precision, high-accuracy ultralong-range swept-source optical coherence tomography using vertical cavity surface emitting laser light source,” Opt. Lett.38(5), 673–675 (2013).
[CrossRef] [PubMed]

T. Klein, R. André, W. Wieser, T. Pfeiffer, and R. Huber, “Joint aperture detection for speckle reduction and increased collection efficiency in ophthalmic MHz OCT,” Biomed. Opt. Express4(4), 619–634 (2013).
[CrossRef] [PubMed]

M. Szkulmowski and M. Wojtkowski, “Averaging techniques for OCT imaging,” Opt. Express21(8), 9757–9773 (2013).
[CrossRef] [PubMed]

H. C. Hendargo, R. Estrada, S. J. Chiu, C. Tomasi, S. Farsiu, and J. A. Izatt, “Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary beds using speckle variance optical coherence tomography,” Biomed. Opt. Express4(6), 803–821 (2013).
[CrossRef] [PubMed]

2012 (14)

M. Szkulmowski, I. Gorczynska, D. Szlag, M. Sylwestrzak, A. Kowalczyk, and M. Wojtkowski, “Efficient reduction of speckle noise in Optical Coherence Tomography,” Opt. Express20(2), 1337–1359 (2012).
[CrossRef] [PubMed]

L. Fang, S. Li, Q. Nie, J. A. Izatt, C. A. Toth, and S. Farsiu, “Sparsity based denoising of spectral domain optical coherence tomography images,” Biomed. Opt. Express3(5), 927–942 (2012).
[CrossRef] [PubMed]

W. Wieser, G. Palte, C. M. Eigenwillig, B. R. Biedermann, T. Pfeiffer, and R. Huber, “Chromatic polarization effects of swept waveforms in FDML lasers and fiber spools,” Opt. Express20(9), 9819–9832 (2012).
[CrossRef] [PubMed]

M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express3(6), 1182–1199 (2012).
[CrossRef] [PubMed]

K. Goda, A. Fard, O. Malik, G. Fu, A. Quach, and B. Jalali, “High-throughput optical coherence tomography at 800 nm,” Opt. Express20(18), 19612–19617 (2012).
[CrossRef] [PubMed]

W. Wieser, T. Klein, D. C. Adler, F. Trépanier, C. M. Eigenwillig, S. Karpf, J. M. Schmitt, and R. Huber, “Extended coherence length megahertz FDML and its application for anterior segment imaging,” Biomed. Opt. Express3(10), 2647–2657 (2012).
[CrossRef] [PubMed]

I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers,” Biomed. Opt. Express3(11), 2733–2751 (2012).
[CrossRef] [PubMed]

K. V. Vienola, B. Braaf, C. K. Sheehy, Q. Yang, P. Tiruveedhula, D. W. Arathorn, J. F. de Boer, and A. Roorda, “Real-time eye motion compensation for OCT imaging with tracking SLO,” Biomed. Opt. Express3(11), 2950–2963 (2012).
[CrossRef] [PubMed]

D. H. Choi, H. Hiro-Oka, K. Shimizu, and K. Ohbayashi, “Spectral domain optical coherence tomography of multi-MHz A-scan rates at 1310 nm range and real-time 4D-display up to 41 volumes/second,” Biomed. Opt. Express3(12), 3067–3086 (2012).
[CrossRef] [PubMed]

C. Blatter, T. Klein, B. Grajciar, T. Schmoll, W. Wieser, R. Andre, R. Huber, and R. A. Leitgeb, “Ultrahigh-speed non-invasive widefield angiography,” J. Biomed. Opt.17(7), 070505 (2012).
[CrossRef] [PubMed]

M. Wojtkowski, B. Kaluzny, and R. J. Zawadzki, “New Directions in Ophthalmic Optical Coherence Tomography,” Optom. Vis. Sci.89(5), 524–542 (2012).
[CrossRef] [PubMed]

N. Suehira, S. Ooto, M. Hangai, K. Matsumoto, N. Tomatsu, T. Yuasa, K. Yamada, and N. Yoshimura, “Three-beam spectral-domain optical coherence tomography for retinal imaging,” J. Biomed. Opt.17(10), 106001 (2012).
[CrossRef] [PubMed]

J. Schindelin, I. Arganda-Carreras, E. Frise, V. Kaynig, M. Longair, T. Pietzsch, S. Preibisch, C. Rueden, S. Saalfeld, B. Schmid, J.-Y. Tinevez, D. J. White, V. Hartenstein, K. Eliceiri, P. Tomancak, and A. Cardona, “Fiji: an open-source platform for biological-image analysis,” Nat. Methods9(7), 676–682 (2012).
[CrossRef] [PubMed]

J. U. Kang, Y. Huang, K. Zhang, Z. Ibrahim, J. Cha, W. P. A. Lee, G. Brandacher, and P. L. Gehlbach, “Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries,” J. Biomed. Opt.17(8), 081403 (2012).
[CrossRef] [PubMed]

2011 (11)

T. Agawa, M. Miura, Y. Ikuno, S. Makita, T. Fabritius, T. Iwasaki, H. Goto, K. Nishida, and Y. Yasuno, “Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography,” Graefes Arch. Clin. Exp. Ophthalmol.249(10), 1485–1492 (2011).
[CrossRef] [PubMed]

C. M. Eigenwillig, T. Klein, W. Wieser, B. R. Biedermann, and R. Huber, “Wavelength swept amplified spontaneous emission source for high speed retinal optical coherence tomography at 1060 nm,” J Biophotonics4(7-8), 552–558 (2011).
[CrossRef] [PubMed]

L. An, T. T. Shen, and R. K. Wang, “Using ultrahigh sensitive optical microangiography to achieve comprehensive depth resolved microvasculature mapping for human retina,” J. Biomed. Opt.16(10), 106013 (2011).
[CrossRef] [PubMed]

S. Makita, F. Jaillon, M. Yamanari, M. Miura, and Y. Yasuno, “Comprehensive in vivo micro-vascular imaging of the human eye by dual-beam-scan Doppler optical coherence angiography,” Opt. Express19(2), 1271–1283 (2011).
[CrossRef] [PubMed]

T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Opt. Express19(4), 3044–3062 (2011).
[CrossRef] [PubMed]

S. Todor, B. Biedermann, W. Wieser, R. Huber, and C. Jirauschek, “Instantaneous lineshape analysis of Fourier domain mode-locked lasers,” Opt. Express19(9), 8802–8807 (2011).
[CrossRef] [PubMed]

B. Antony, M. D. Abràmoff, L. Tang, W. D. Ramdas, J. R. Vingerling, N. M. Jansonius, K. Lee, Y. H. Kwon, M. Sonka, and M. K. Garvin, “Automated 3-D method for the correction of axial artifacts in spectral-domain optical coherence tomography images,” Biomed. Opt. Express2(8), 2403–2416 (2011).
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L. An, P. Li, T. T. Shen, and R. Wang, “High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A‑lines per second,” Biomed. Opt. Express2(10), 2770–2783 (2011).
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B. Braaf, K. A. Vermeer, V. A. D. P. Sicam, E. van Zeeburg, J. C. van Meurs, and J. F. de Boer, “Phase-stabilized optical frequency domain imaging at 1-µm for the measurement of blood flow in the human choroid,” Opt. Express19(21), 20886–20903 (2011).
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D. C. Adler, W. Wieser, F. Trepanier, J. M. Schmitt, and R. A. Huber, “Extended coherence length Fourier domain mode locked lasers at 1310 nm,” Opt. Express19(21), 20930–20939 (2011).
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Y. Li, G. Gregori, B. L. Lam, and P. J. Rosenfeld, “Automatic montage of SD-OCT data sets,” Opt. Express19(27), 26239–26248 (2011).
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2010 (8)

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-Megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express18(14), 14685–14704 (2010).
[CrossRef] [PubMed]

S. Marschall, T. Klein, W. Wieser, B. R. Biedermann, K. Hsu, K. P. Hansen, B. Sumpf, K. H. Hasler, G. Erbert, O. B. Jensen, C. Pedersen, R. Huber, and P. E. Andersen, “Fourier domain mode-locked swept source at 1050 nm based on a tapered amplifier,” Opt. Express18(15), 15820–15831 (2010).
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Y. K. Tao, S. Farsiu, and J. A. Izatt, “Interlaced spectrally encoded confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography,” Biomed. Opt. Express1(2), 431–440 (2010).
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W.-Y. Oh, B. J. Vakoc, M. Shishkov, G. J. Tearney, and B. E. Bouma, “>400 kHz repetition rate wavelength-swept laser and application to high-speed optical frequency domain imaging,” Opt. Lett.35(17), 2919–2921 (2010).
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B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express18(19), 20029–20048 (2010).
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Y. K. Tao, J. P. Ehlers, C. A. Toth, and J. A. Izatt, “Intraoperative spectral domain optical coherence tomography for vitreoretinal surgery,” Opt. Lett.35(20), 3315–3317 (2010).
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T. Schmoll, C. Kolbitsch, and R. A. Leitgeb, “In vivo functional retinal optical coherence tomography,” J. Biomed. Opt.15(4), 041513 (2010).
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S. Lee, M. Young, M. V. Sarunic, and M. F. Beg, “End-to-end pipeline for spectral domain optical coherence tomography and morphometric analysis of human optic nerve head,” J. Med. Biol. Eng.31, 9 (2010).

2009 (6)

2008 (6)

B. Povazay, B. Hermann, B. Hofer, V. Kajić, E. Simpson, T. Bridgford, and W. Drexler, “Wide-Field Optical Coherence Tomography of the Choroid In Vivo,” Invest. Ophthalmol. Vis. Sci.50(4), 1856–1863 (2008).
[CrossRef] [PubMed]

A. G. Podoleanu and R. B. Rosen, “Combinations of techniques in imaging the retina with high resolution,” Prog. Retin. Eye Res.27(4), 464–499 (2008).
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V. J. Srinivasan, D. C. Adler, Y. L. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-Speed Optical Coherence Tomography for Three-Dimensional and En Face Imaging of the Retina and Optic Nerve Head,” Invest. Ophthalmol. Vis. Sci.49(11), 5103–5110 (2008).
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A. S. Neubauer, M. Kernt, C. Haritoglou, S. G. Priglinger, A. Kampik, and M. W. Ulbig, “Nonmydriatic screening for diabetic retinopathy by ultra-widefield scanning laser ophthalmoscopy (Optomap),” Graefes Arch. Clin. Exp. Ophthalmol.246(2), 229–235 (2008).
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D. Choi, H. Hiro-Oka, H. Furukawa, R. Yoshimura, M. Nakanishi, K. Shimizu, and K. Ohbayashi, “Fourier domain optical coherence tomography using optical demultiplexers imaging at 60,000,000 lines/s,” Opt. Lett.33(12), 1318–1320 (2008).
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B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. L. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed Spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express16(19), 15149–15169 (2008).
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2007 (4)

R. J. Zawadzki, A. R. Fuller, S. S. Choi, D. F. Wiley, B. Hamann, and J. S. Werner, “Correction of motion artifacts and scanning beam distortions in 3D ophthalmic optical coherence tomography imaging,” Proc. SPIE64260, 64260 (2007).

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt.12(4), 041211 (2007).
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R. Huber, D. C. Adler, V. J. Srinivasan, and J. G. Fujimoto, “Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second,” Opt. Lett.32(14), 2049–2051 (2007).
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Y. Chen, D. M. de Bruin, C. Kerbage, and J. F. de Boer, “Spectrally balanced detection for optical frequency domain imaging,” Opt. Express15(25), 16390–16399 (2007).
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2006 (4)

2005 (3)

2004 (4)

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, “Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy,” J. Biomed. Opt.9(1), 86–93 (2004).
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M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, A. Kowalczyk, W. Wasilewski, and C. Radzewicz, “Ophthalmic imaging by spectral optical coherence tomography,” Am. J. Ophthalmol.138(3), 412–419 (2004).
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A. Podoleanu, I. Charalambous, L. Plesea, A. Dogariu, and R. Rosen, “Correction of distortions in optical coherence tomography imaging of the eye,” Phys. Med. Biol.49(7), 1277–1294 (2004).
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R. D. Ferguson, D. X. Hammer, L. A. Paunescu, S. Beaton, and J. S. Schuman, “Tracking optical coherence tomography,” Opt. Lett.29(18), 2139–2141 (2004).
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2003 (3)

1999 (2)

A. M. Rollins and J. A. Izatt, “Optimal interferometer designs for optical coherence tomography,” Opt. Lett.24(21), 1484–1486 (1999).
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J. M. Schmitt, S. H. Xiang, and K. M. Yung, “Speckle in Optical Coherence Tomography,” J. Biomed. Opt.4(1), 95–105 (1999).
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1998 (1)

P. Thévenaz, U. E. Ruttimann, and M. Unser, “A pyramid approach to subpixel registration based on intensity,” IEEE Trans. Image Process.7(1), 27–41 (1998).
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1995 (1)

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol.113(3), 325–332 (1995).
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1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
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Abràmoff, M. D.

Adler, D. C.

Agawa, T.

T. Agawa, M. Miura, Y. Ikuno, S. Makita, T. Fabritius, T. Iwasaki, H. Goto, K. Nishida, and Y. Yasuno, “Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography,” Graefes Arch. Clin. Exp. Ophthalmol.249(10), 1485–1492 (2011).
[CrossRef] [PubMed]

Ahlers, C.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Považay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, “Three-Dimensional Ultrahigh-Resolution Optical Coherence Tomography of Macular Diseases,” Invest. Ophthalmol. Vis. Sci.46(9), 3393–3402 (2005).
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Akagi-Kurashige, Y.

A. A. Ellabban, A. Tsujikawa, A. Matsumoto, K. Yamashiro, A. Oishi, S. Ooto, I. Nakata, Y. Akagi-Kurashige, M. Miyake, H. S. Elnahas, T. M. Radwan, K. A. Zaky, and N. Yoshimura, “Three-Dimensional Tomographic Features of Dome-Shaped Macula by Swept-Source Optical Coherence Tomography,” Am. J. Ophthalmol.155(2), 320–328, e2 (2013).
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An, L.

L. An, P. Li, T. T. Shen, and R. Wang, “High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A‑lines per second,” Biomed. Opt. Express2(10), 2770–2783 (2011).
[CrossRef] [PubMed]

L. An, T. T. Shen, and R. K. Wang, “Using ultrahigh sensitive optical microangiography to achieve comprehensive depth resolved microvasculature mapping for human retina,” J. Biomed. Opt.16(10), 106013 (2011).
[CrossRef] [PubMed]

Andersen, P.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

Andersen, P. E.

Andre, R.

C. Blatter, T. Klein, B. Grajciar, T. Schmoll, W. Wieser, R. Andre, R. Huber, and R. A. Leitgeb, “Ultrahigh-speed non-invasive widefield angiography,” J. Biomed. Opt.17(7), 070505 (2012).
[CrossRef] [PubMed]

André, R.

Antony, B.

Arathorn, D. W.

Arganda-Carreras, I.

J. Schindelin, I. Arganda-Carreras, E. Frise, V. Kaynig, M. Longair, T. Pietzsch, S. Preibisch, C. Rueden, S. Saalfeld, B. Schmid, J.-Y. Tinevez, D. J. White, V. Hartenstein, K. Eliceiri, P. Tomancak, and A. Cardona, “Fiji: an open-source platform for biological-image analysis,” Nat. Methods9(7), 676–682 (2012).
[CrossRef] [PubMed]

Bajraszewski, T.

M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, A. Kowalczyk, W. Wasilewski, and C. Radzewicz, “Ophthalmic imaging by spectral optical coherence tomography,” Am. J. Ophthalmol.138(3), 412–419 (2004).
[CrossRef] [PubMed]

Barry, S.

Baumann, B.

Beaton, S.

Beg, M. F.

S. Lee, M. Young, M. V. Sarunic, and M. F. Beg, “End-to-end pipeline for spectral domain optical coherence tomography and morphometric analysis of human optic nerve head,” J. Med. Biol. Eng.31, 9 (2010).

Biedermann, B.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

S. Todor, B. Biedermann, W. Wieser, R. Huber, and C. Jirauschek, “Instantaneous lineshape analysis of Fourier domain mode-locked lasers,” Opt. Express19(9), 8802–8807 (2011).
[CrossRef] [PubMed]

Biedermann, B. R.

W. Wieser, G. Palte, C. M. Eigenwillig, B. R. Biedermann, T. Pfeiffer, and R. Huber, “Chromatic polarization effects of swept waveforms in FDML lasers and fiber spools,” Opt. Express20(9), 9819–9832 (2012).
[CrossRef] [PubMed]

C. M. Eigenwillig, T. Klein, W. Wieser, B. R. Biedermann, and R. Huber, “Wavelength swept amplified spontaneous emission source for high speed retinal optical coherence tomography at 1060 nm,” J Biophotonics4(7-8), 552–558 (2011).
[CrossRef] [PubMed]

T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Opt. Express19(4), 3044–3062 (2011).
[CrossRef] [PubMed]

S. Marschall, T. Klein, W. Wieser, B. R. Biedermann, K. Hsu, K. P. Hansen, B. Sumpf, K. H. Hasler, G. Erbert, O. B. Jensen, C. Pedersen, R. Huber, and P. E. Andersen, “Fourier domain mode-locked swept source at 1050 nm based on a tapered amplifier,” Opt. Express18(15), 15820–15831 (2010).
[CrossRef] [PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-Megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express18(14), 14685–14704 (2010).
[CrossRef] [PubMed]

C. M. Eigenwillig, B. R. Biedermann, W. Wieser, and R. Huber, “Wavelength swept amplified spontaneous emission source,” Opt. Express17(21), 18794–18807 (2009).
[CrossRef] [PubMed]

B. R. Biedermann, W. Wieser, C. M. Eigenwillig, T. Klein, and R. Huber, “Dispersion, coherence and noise of Fourier domain mode locked lasers,” Opt. Express17(12), 9947–9961 (2009).
[CrossRef] [PubMed]

Bird, A. C.

Blatter, C.

C. Blatter, T. Klein, B. Grajciar, T. Schmoll, W. Wieser, R. Andre, R. Huber, and R. A. Leitgeb, “Ultrahigh-speed non-invasive widefield angiography,” J. Biomed. Opt.17(7), 070505 (2012).
[CrossRef] [PubMed]

Blinder, S.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt.12(4), 041211 (2007).
[CrossRef] [PubMed]

Bock, R.

Bonesi, M.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
[CrossRef] [PubMed]

Bouma, B.

Bouma, B. E.

Boxer, A.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, “Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy,” J. Biomed. Opt.9(1), 86–93 (2004).
[CrossRef] [PubMed]

Braaf, B.

Brandacher, G.

J. U. Kang, Y. Huang, K. Zhang, Z. Ibrahim, J. Cha, W. P. A. Lee, G. Brandacher, and P. L. Gehlbach, “Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries,” J. Biomed. Opt.17(8), 081403 (2012).
[CrossRef] [PubMed]

Bridgford, T.

B. Povazay, B. Hermann, B. Hofer, V. Kajić, E. Simpson, T. Bridgford, and W. Drexler, “Wide-Field Optical Coherence Tomography of the Choroid In Vivo,” Invest. Ophthalmol. Vis. Sci.50(4), 1856–1863 (2008).
[CrossRef] [PubMed]

Cable, A.

Cable, A. E.

Cardona, A.

J. Schindelin, I. Arganda-Carreras, E. Frise, V. Kaynig, M. Longair, T. Pietzsch, S. Preibisch, C. Rueden, S. Saalfeld, B. Schmid, J.-Y. Tinevez, D. J. White, V. Hartenstein, K. Eliceiri, P. Tomancak, and A. Cardona, “Fiji: an open-source platform for biological-image analysis,” Nat. Methods9(7), 676–682 (2012).
[CrossRef] [PubMed]

Cense, B.

Cha, J.

J. U. Kang, Y. Huang, K. Zhang, Z. Ibrahim, J. Cha, W. P. A. Lee, G. Brandacher, and P. L. Gehlbach, “Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries,” J. Biomed. Opt.17(8), 081403 (2012).
[CrossRef] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Charalambous, I.

A. Podoleanu, I. Charalambous, L. Plesea, A. Dogariu, and R. Rosen, “Correction of distortions in optical coherence tomography imaging of the eye,” Phys. Med. Biol.49(7), 1277–1294 (2004).
[CrossRef] [PubMed]

Chen, R. W. S.

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. S. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration,” Br. J. Ophthalmol.93(5), 603–609 (2009).
[CrossRef] [PubMed]

Chen, T.

Chen, Y.

Chen, Y. L.

B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. L. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed Spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express16(19), 15149–15169 (2008).
[CrossRef] [PubMed]

V. J. Srinivasan, D. C. Adler, Y. L. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-Speed Optical Coherence Tomography for Three-Dimensional and En Face Imaging of the Retina and Optic Nerve Head,” Invest. Ophthalmol. Vis. Sci.49(11), 5103–5110 (2008).
[CrossRef] [PubMed]

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Choi, D.

Choi, D. H.

Choi, S. S.

R. J. Zawadzki, S. S. Choi, A. R. Fuller, J. W. Evans, B. Hamann, and J. S. Werner, “Cellular resolution volumetric in vivo retinal imaging with adaptive optics-optical coherence tomography,” Opt. Express17(5), 4084–4094 (2009).
[CrossRef] [PubMed]

R. J. Zawadzki, A. R. Fuller, S. S. Choi, D. F. Wiley, B. Hamann, and J. S. Werner, “Correction of motion artifacts and scanning beam distortions in 3D ophthalmic optical coherence tomography imaging,” Proc. SPIE64260, 64260 (2007).

Cucu, R. G.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, “Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy,” J. Biomed. Opt.9(1), 86–93 (2004).
[CrossRef] [PubMed]

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de Boer, J. F.

de Bruin, D. M.

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A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, “Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy,” J. Biomed. Opt.9(1), 86–93 (2004).
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A. Podoleanu, I. Charalambous, L. Plesea, A. Dogariu, and R. Rosen, “Correction of distortions in optical coherence tomography imaging of the eye,” Phys. Med. Biol.49(7), 1277–1294 (2004).
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B. Povazay, B. Hofer, C. Torti, B. Hermann, A. R. Tumlinson, M. Esmaeelpour, C. A. Egan, A. C. Bird, and W. Drexler, “Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomography,” Opt. Express17(5), 4134–4150 (2009).
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B. Povazay, B. Hermann, B. Hofer, V. Kajić, E. Simpson, T. Bridgford, and W. Drexler, “Wide-Field Optical Coherence Tomography of the Choroid In Vivo,” Invest. Ophthalmol. Vis. Sci.50(4), 1856–1863 (2008).
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B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt.12(4), 041211 (2007).
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U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Považay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, “Three-Dimensional Ultrahigh-Resolution Optical Coherence Tomography of Macular Diseases,” Invest. Ophthalmol. Vis. Sci.46(9), 3393–3402 (2005).
[CrossRef] [PubMed]

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I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers,” Biomed. Opt. Express3(11), 2733–2751 (2012).
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B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express18(19), 20029–20048 (2010).
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I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. S. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration,” Br. J. Ophthalmol.93(5), 603–609 (2009).
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V. J. Srinivasan, D. C. Adler, Y. L. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-Speed Optical Coherence Tomography for Three-Dimensional and En Face Imaging of the Retina and Optic Nerve Head,” Invest. Ophthalmol. Vis. Sci.49(11), 5103–5110 (2008).
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A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, “Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy,” J. Biomed. Opt.9(1), 86–93 (2004).
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W. Wieser, G. Palte, C. M. Eigenwillig, B. R. Biedermann, T. Pfeiffer, and R. Huber, “Chromatic polarization effects of swept waveforms in FDML lasers and fiber spools,” Opt. Express20(9), 9819–9832 (2012).
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W. Wieser, T. Klein, D. C. Adler, F. Trépanier, C. M. Eigenwillig, S. Karpf, J. M. Schmitt, and R. Huber, “Extended coherence length megahertz FDML and its application for anterior segment imaging,” Biomed. Opt. Express3(10), 2647–2657 (2012).
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T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Opt. Express19(4), 3044–3062 (2011).
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C. M. Eigenwillig, T. Klein, W. Wieser, B. R. Biedermann, and R. Huber, “Wavelength swept amplified spontaneous emission source for high speed retinal optical coherence tomography at 1060 nm,” J Biophotonics4(7-8), 552–558 (2011).
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W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-Megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express18(14), 14685–14704 (2010).
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C. M. Eigenwillig, B. R. Biedermann, W. Wieser, and R. Huber, “Wavelength swept amplified spontaneous emission source,” Opt. Express17(21), 18794–18807 (2009).
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B. R. Biedermann, W. Wieser, C. M. Eigenwillig, T. Klein, and R. Huber, “Dispersion, coherence and noise of Fourier domain mode locked lasers,” Opt. Express17(12), 9947–9961 (2009).
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J. Schindelin, I. Arganda-Carreras, E. Frise, V. Kaynig, M. Longair, T. Pietzsch, S. Preibisch, C. Rueden, S. Saalfeld, B. Schmid, J.-Y. Tinevez, D. J. White, V. Hartenstein, K. Eliceiri, P. Tomancak, and A. Cardona, “Fiji: an open-source platform for biological-image analysis,” Nat. Methods9(7), 676–682 (2012).
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A. A. Ellabban, A. Tsujikawa, A. Matsumoto, K. Yamashiro, A. Oishi, S. Ooto, I. Nakata, Y. Akagi-Kurashige, M. Miyake, H. S. Elnahas, T. M. Radwan, K. A. Zaky, and N. Yoshimura, “Three-Dimensional Tomographic Features of Dome-Shaped Macula by Swept-Source Optical Coherence Tomography,” Am. J. Ophthalmol.155(2), 320–328, e2 (2013).
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T. Agawa, M. Miura, Y. Ikuno, S. Makita, T. Fabritius, T. Iwasaki, H. Goto, K. Nishida, and Y. Yasuno, “Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography,” Graefes Arch. Clin. Exp. Ophthalmol.249(10), 1485–1492 (2011).
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B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt.12(4), 041211 (2007).
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Fard, A.

Farsiu, S.

Fercher, A. F.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Považay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, “Three-Dimensional Ultrahigh-Resolution Optical Coherence Tomography of Macular Diseases,” Invest. Ophthalmol. Vis. Sci.46(9), 3393–3402 (2005).
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Fisher, Y.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, “Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy,” J. Biomed. Opt.9(1), 86–93 (2004).
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D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
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J. Schindelin, I. Arganda-Carreras, E. Frise, V. Kaynig, M. Longair, T. Pietzsch, S. Preibisch, C. Rueden, S. Saalfeld, B. Schmid, J.-Y. Tinevez, D. J. White, V. Hartenstein, K. Eliceiri, P. Tomancak, and A. Cardona, “Fiji: an open-source platform for biological-image analysis,” Nat. Methods9(7), 676–682 (2012).
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Fujimoto, J. G.

I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, J. Jiang, J. G. Fujimoto, and A. E. Cable, “High-precision, high-accuracy ultralong-range swept-source optical coherence tomography using vertical cavity surface emitting laser light source,” Opt. Lett.38(5), 673–675 (2013).
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I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers,” Biomed. Opt. Express3(11), 2733–2751 (2012).
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M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express3(6), 1182–1199 (2012).
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B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express18(19), 20029–20048 (2010).
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I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. S. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration,” Br. J. Ophthalmol.93(5), 603–609 (2009).
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B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. L. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed Spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express16(19), 15149–15169 (2008).
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V. J. Srinivasan, D. C. Adler, Y. L. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-Speed Optical Coherence Tomography for Three-Dimensional and En Face Imaging of the Retina and Optic Nerve Head,” Invest. Ophthalmol. Vis. Sci.49(11), 5103–5110 (2008).
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R. Huber, D. C. Adler, V. J. Srinivasan, and J. G. Fujimoto, “Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second,” Opt. Lett.32(14), 2049–2051 (2007).
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R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express14(8), 3225–3237 (2006).
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R. Huber, D. C. Adler, and J. G. Fujimoto, “Buffered Fourier domain mode locking: unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s,” Opt. Lett.31(20), 2975–2977 (2006).
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D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
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R. J. Zawadzki, S. S. Choi, A. R. Fuller, J. W. Evans, B. Hamann, and J. S. Werner, “Cellular resolution volumetric in vivo retinal imaging with adaptive optics-optical coherence tomography,” Opt. Express17(5), 4084–4094 (2009).
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R. J. Zawadzki, A. R. Fuller, S. S. Choi, D. F. Wiley, B. Hamann, and J. S. Werner, “Correction of motion artifacts and scanning beam distortions in 3D ophthalmic optical coherence tomography imaging,” Proc. SPIE64260, 64260 (2007).

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Garcia, P.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, “Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy,” J. Biomed. Opt.9(1), 86–93 (2004).
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J. U. Kang, Y. Huang, K. Zhang, Z. Ibrahim, J. Cha, W. P. A. Lee, G. Brandacher, and P. L. Gehlbach, “Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries,” J. Biomed. Opt.17(8), 081403 (2012).
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A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, “Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy,” J. Biomed. Opt.9(1), 86–93 (2004).
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B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt.12(4), 041211 (2007).
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Gorczynska, I.

M. Szkulmowski, I. Gorczynska, D. Szlag, M. Sylwestrzak, A. Kowalczyk, and M. Wojtkowski, “Efficient reduction of speckle noise in Optical Coherence Tomography,” Opt. Express20(2), 1337–1359 (2012).
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I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. S. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration,” Br. J. Ophthalmol.93(5), 603–609 (2009).
[CrossRef] [PubMed]

B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. L. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed Spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express16(19), 15149–15169 (2008).
[CrossRef] [PubMed]

V. J. Srinivasan, D. C. Adler, Y. L. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-Speed Optical Coherence Tomography for Three-Dimensional and En Face Imaging of the Retina and Optic Nerve Head,” Invest. Ophthalmol. Vis. Sci.49(11), 5103–5110 (2008).
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T. Agawa, M. Miura, Y. Ikuno, S. Makita, T. Fabritius, T. Iwasaki, H. Goto, K. Nishida, and Y. Yasuno, “Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography,” Graefes Arch. Clin. Exp. Ophthalmol.249(10), 1485–1492 (2011).
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T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
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C. Blatter, T. Klein, B. Grajciar, T. Schmoll, W. Wieser, R. Andre, R. Huber, and R. A. Leitgeb, “Ultrahigh-speed non-invasive widefield angiography,” J. Biomed. Opt.17(7), 070505 (2012).
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D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
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Grulkowski, I.

Hamann, B.

R. J. Zawadzki, S. S. Choi, A. R. Fuller, J. W. Evans, B. Hamann, and J. S. Werner, “Cellular resolution volumetric in vivo retinal imaging with adaptive optics-optical coherence tomography,” Opt. Express17(5), 4084–4094 (2009).
[CrossRef] [PubMed]

R. J. Zawadzki, A. R. Fuller, S. S. Choi, D. F. Wiley, B. Hamann, and J. S. Werner, “Correction of motion artifacts and scanning beam distortions in 3D ophthalmic optical coherence tomography imaging,” Proc. SPIE64260, 64260 (2007).

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Hangai, M.

N. Suehira, S. Ooto, M. Hangai, K. Matsumoto, N. Tomatsu, T. Yuasa, K. Yamada, and N. Yoshimura, “Three-beam spectral-domain optical coherence tomography for retinal imaging,” J. Biomed. Opt.17(10), 106001 (2012).
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J. Schindelin, I. Arganda-Carreras, E. Frise, V. Kaynig, M. Longair, T. Pietzsch, S. Preibisch, C. Rueden, S. Saalfeld, B. Schmid, J.-Y. Tinevez, D. J. White, V. Hartenstein, K. Eliceiri, P. Tomancak, and A. Cardona, “Fiji: an open-source platform for biological-image analysis,” Nat. Methods9(7), 676–682 (2012).
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Hee, M. R.

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol.113(3), 325–332 (1995).
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D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
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Hermann, B.

B. Povazay, B. Hofer, C. Torti, B. Hermann, A. R. Tumlinson, M. Esmaeelpour, C. A. Egan, A. C. Bird, and W. Drexler, “Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomography,” Opt. Express17(5), 4134–4150 (2009).
[CrossRef] [PubMed]

B. Povazay, B. Hermann, B. Hofer, V. Kajić, E. Simpson, T. Bridgford, and W. Drexler, “Wide-Field Optical Coherence Tomography of the Choroid In Vivo,” Invest. Ophthalmol. Vis. Sci.50(4), 1856–1863 (2008).
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B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt.12(4), 041211 (2007).
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Hitzenberger, C. K.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
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J. U. Kang, Y. Huang, K. Zhang, Z. Ibrahim, J. Cha, W. P. A. Lee, G. Brandacher, and P. L. Gehlbach, “Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries,” J. Biomed. Opt.17(8), 081403 (2012).
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W. Wieser, T. Klein, D. C. Adler, F. Trépanier, C. M. Eigenwillig, S. Karpf, J. M. Schmitt, and R. Huber, “Extended coherence length megahertz FDML and its application for anterior segment imaging,” Biomed. Opt. Express3(10), 2647–2657 (2012).
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C. M. Eigenwillig, T. Klein, W. Wieser, B. R. Biedermann, and R. Huber, “Wavelength swept amplified spontaneous emission source for high speed retinal optical coherence tomography at 1060 nm,” J Biophotonics4(7-8), 552–558 (2011).
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W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-Megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express18(14), 14685–14704 (2010).
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B. R. Biedermann, W. Wieser, C. M. Eigenwillig, T. Klein, and R. Huber, “Dispersion, coherence and noise of Fourier domain mode locked lasers,” Opt. Express17(12), 9947–9961 (2009).
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Ibrahim, Z.

J. U. Kang, Y. Huang, K. Zhang, Z. Ibrahim, J. Cha, W. P. A. Lee, G. Brandacher, and P. L. Gehlbach, “Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries,” J. Biomed. Opt.17(8), 081403 (2012).
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Ikuno, Y.

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T. Agawa, M. Miura, Y. Ikuno, S. Makita, T. Fabritius, T. Iwasaki, H. Goto, K. Nishida, and Y. Yasuno, “Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography,” Graefes Arch. Clin. Exp. Ophthalmol.249(10), 1485–1492 (2011).
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B. Povazay, B. Hermann, B. Hofer, V. Kajić, E. Simpson, T. Bridgford, and W. Drexler, “Wide-Field Optical Coherence Tomography of the Choroid In Vivo,” Invest. Ophthalmol. Vis. Sci.50(4), 1856–1863 (2008).
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M. Wojtkowski, B. Kaluzny, and R. J. Zawadzki, “New Directions in Ophthalmic Optical Coherence Tomography,” Optom. Vis. Sci.89(5), 524–542 (2012).
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A. S. Neubauer, M. Kernt, C. Haritoglou, S. G. Priglinger, A. Kampik, and M. W. Ulbig, “Nonmydriatic screening for diabetic retinopathy by ultra-widefield scanning laser ophthalmoscopy (Optomap),” Graefes Arch. Clin. Exp. Ophthalmol.246(2), 229–235 (2008).
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J. U. Kang, Y. Huang, K. Zhang, Z. Ibrahim, J. Cha, W. P. A. Lee, G. Brandacher, and P. L. Gehlbach, “Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries,” J. Biomed. Opt.17(8), 081403 (2012).
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A. S. Neubauer, M. Kernt, C. Haritoglou, S. G. Priglinger, A. Kampik, and M. W. Ulbig, “Nonmydriatic screening for diabetic retinopathy by ultra-widefield scanning laser ophthalmoscopy (Optomap),” Graefes Arch. Clin. Exp. Ophthalmol.246(2), 229–235 (2008).
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Klein, T.

T. Klein, R. André, W. Wieser, T. Pfeiffer, and R. Huber, “Joint aperture detection for speckle reduction and increased collection efficiency in ophthalmic MHz OCT,” Biomed. Opt. Express4(4), 619–634 (2013).
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T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Götzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt.18(2), 026008 (2013).
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S. Marschall, T. Klein, W. Wieser, B. R. Biedermann, K. Hsu, K. P. Hansen, B. Sumpf, K. H. Hasler, G. Erbert, O. B. Jensen, C. Pedersen, R. Huber, and P. E. Andersen, “Fourier domain mode-locked swept source at 1050 nm based on a tapered amplifier,” Opt. Express18(15), 15820–15831 (2010).
[CrossRef] [PubMed]

B. R. Biedermann, W. Wieser, C. M. Eigenwillig, T. Klein, and R. Huber, “Dispersion, coherence and noise of Fourier domain mode locked lasers,” Opt. Express17(12), 9947–9961 (2009).
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J. U. Kang, Y. Huang, K. Zhang, Z. Ibrahim, J. Cha, W. P. A. Lee, G. Brandacher, and P. L. Gehlbach, “Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries,” J. Biomed. Opt.17(8), 081403 (2012).
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C. Blatter, T. Klein, B. Grajciar, T. Schmoll, W. Wieser, R. Andre, R. Huber, and R. A. Leitgeb, “Ultrahigh-speed non-invasive widefield angiography,” J. Biomed. Opt.17(7), 070505 (2012).
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Li, S.

Li, Y.

Lin, C. P.

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol.113(3), 325–332 (1995).
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Longair, M.

J. Schindelin, I. Arganda-Carreras, E. Frise, V. Kaynig, M. Longair, T. Pietzsch, S. Preibisch, C. Rueden, S. Saalfeld, B. Schmid, J.-Y. Tinevez, D. J. White, V. Hartenstein, K. Eliceiri, P. Tomancak, and A. Cardona, “Fiji: an open-source platform for biological-image analysis,” Nat. Methods9(7), 676–682 (2012).
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Macknik, S. L.

S. Martinez-Conde, S. L. Macknik, X. G. Troncoso, and D. H. Hubel, “Microsaccades: a neurophysiological analysis,” Trends Neurosci.32(9), 463–475 (2009).
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S. Makita, F. Jaillon, M. Yamanari, M. Miura, and Y. Yasuno, “Comprehensive in vivo micro-vascular imaging of the human eye by dual-beam-scan Doppler optical coherence angiography,” Opt. Express19(2), 1271–1283 (2011).
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T. Agawa, M. Miura, Y. Ikuno, S. Makita, T. Fabritius, T. Iwasaki, H. Goto, K. Nishida, and Y. Yasuno, “Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography,” Graefes Arch. Clin. Exp. Ophthalmol.249(10), 1485–1492 (2011).
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S. Martinez-Conde, S. L. Macknik, X. G. Troncoso, and D. H. Hubel, “Microsaccades: a neurophysiological analysis,” Trends Neurosci.32(9), 463–475 (2009).
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Michels, S.

U. Schmidt-Erfurth, R. A. Leitgeb, S. Michels, B. Považay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, “Three-Dimensional Ultrahigh-Resolution Optical Coherence Tomography of Macular Diseases,” Invest. Ophthalmol. Vis. Sci.46(9), 3393–3402 (2005).
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S. Makita, F. Jaillon, M. Yamanari, M. Miura, and Y. Yasuno, “Comprehensive in vivo micro-vascular imaging of the human eye by dual-beam-scan Doppler optical coherence angiography,” Opt. Express19(2), 1271–1283 (2011).
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T. Agawa, M. Miura, Y. Ikuno, S. Makita, T. Fabritius, T. Iwasaki, H. Goto, K. Nishida, and Y. Yasuno, “Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography,” Graefes Arch. Clin. Exp. Ophthalmol.249(10), 1485–1492 (2011).
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Morgan, J. E.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt.12(4), 041211 (2007).
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Neubauer, A. S.

A. S. Neubauer, M. Kernt, C. Haritoglou, S. G. Priglinger, A. Kampik, and M. W. Ulbig, “Nonmydriatic screening for diabetic retinopathy by ultra-widefield scanning laser ophthalmoscopy (Optomap),” Graefes Arch. Clin. Exp. Ophthalmol.246(2), 229–235 (2008).
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T. Agawa, M. Miura, Y. Ikuno, S. Makita, T. Fabritius, T. Iwasaki, H. Goto, K. Nishida, and Y. Yasuno, “Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography,” Graefes Arch. Clin. Exp. Ophthalmol.249(10), 1485–1492 (2011).
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Ohbayashi, K.

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A. A. Ellabban, A. Tsujikawa, A. Matsumoto, K. Yamashiro, A. Oishi, S. Ooto, I. Nakata, Y. Akagi-Kurashige, M. Miyake, H. S. Elnahas, T. M. Radwan, K. A. Zaky, and N. Yoshimura, “Three-Dimensional Tomographic Features of Dome-Shaped Macula by Swept-Source Optical Coherence Tomography,” Am. J. Ophthalmol.155(2), 320–328, e2 (2013).
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J. Schindelin, I. Arganda-Carreras, E. Frise, V. Kaynig, M. Longair, T. Pietzsch, S. Preibisch, C. Rueden, S. Saalfeld, B. Schmid, J.-Y. Tinevez, D. J. White, V. Hartenstein, K. Eliceiri, P. Tomancak, and A. Cardona, “Fiji: an open-source platform for biological-image analysis,” Nat. Methods9(7), 676–682 (2012).
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A. G. Podoleanu and R. B. Rosen, “Combinations of techniques in imaging the retina with high resolution,” Prog. Retin. Eye Res.27(4), 464–499 (2008).
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A. S. Neubauer, M. Kernt, C. Haritoglou, S. G. Priglinger, A. Kampik, and M. W. Ulbig, “Nonmydriatic screening for diabetic retinopathy by ultra-widefield scanning laser ophthalmoscopy (Optomap),” Graefes Arch. Clin. Exp. Ophthalmol.246(2), 229–235 (2008).
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Puliafito, C. A.

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A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, “Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy,” J. Biomed. Opt.9(1), 86–93 (2004).
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Roorda, A.

Rosen, R.

A. Podoleanu, I. Charalambous, L. Plesea, A. Dogariu, and R. Rosen, “Correction of distortions in optical coherence tomography imaging of the eye,” Phys. Med. Biol.49(7), 1277–1294 (2004).
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A. G. Podoleanu and R. B. Rosen, “Combinations of techniques in imaging the retina with high resolution,” Prog. Retin. Eye Res.27(4), 464–499 (2008).
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M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express3(6), 1182–1199 (2012).
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W. Wieser, T. Klein, D. C. Adler, F. Trépanier, C. M. Eigenwillig, S. Karpf, J. M. Schmitt, and R. Huber, “Extended coherence length megahertz FDML and its application for anterior segment imaging,” Biomed. Opt. Express3(10), 2647–2657 (2012).
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K. V. Vienola, B. Braaf, C. K. Sheehy, Q. Yang, P. Tiruveedhula, D. W. Arathorn, J. F. de Boer, and A. Roorda, “Real-time eye motion compensation for OCT imaging with tracking SLO,” Biomed. Opt. Express3(11), 2950–2963 (2012).
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Br. J. Ophthalmol. (1)

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J. U. Kang, Y. Huang, K. Zhang, Z. Ibrahim, J. Cha, W. P. A. Lee, G. Brandacher, and P. L. Gehlbach, “Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries,” J. Biomed. Opt.17(8), 081403 (2012).
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Supplementary Material (3)

» Media 1: MOV (47421 KB)     
» Media 2: MOV (57376 KB)     
» Media 3: MOV (5873 KB)     

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Figures (9)

Fig. 1
Fig. 1

Sensitivity vs. axial line rate for retinal imaging at 1050 nm (0.7A/W photodetector responsivity) for a) 1.4 mW and b) 3.5 mW sample arm power. Blue shaded regions: Shot noise limited sensitivity with 100% collection efficiency. Red shaded regions: sensitivity with a 3 dB penalty (for instance, 65% coupling efficiency and additional 1.13 dB penalty). Horizontal black lines indicate the limits for 95 dB (“clinical imaging”) and 90 dB (“research”) sensitivity.

Fig. 2
Fig. 2

FDML laser cavity and buffer stage layout (4x buffering version shown). AWG: arbitrary waveform generator; LDC: laser diode controller; SOA: semiconductor optical amplifier; ISO: isolator; PC: polarization controller; Yb: ytterbium doped fiber; BFP-TF: bulk fiber Fabry-Perot tunable filter; Pol: polarizer; pump: 978nm pump diode; cfBG: chirped fiber Bragg grating (Teraxion, Inc.), OSA: optical spectrum analyzer; MZI: Mach-Zehnder interferometer (used for the sensitivity roll-off measurements).

Fig. 3
Fig. 3

Laser spectra and sensitivity roll-off at axial line rates of a) 1.68 MHz and b) 3.35 MHz. Note that for long imaging depths, sensitivity decay is dominated by the detection system’s 1 GHz electronic bandwidth.

Fig. 4
Fig. 4

Dual-beam OCT imaging setup. BPD: Balanced photo-receiver; PC: polarization controller; DC: dispersion compensating glass blocks; Recal.: recalibration arm; Ref.: reference arm; Galvo: galvanometer mirrors (x and y), L1/L2: relay lenses; BS: beam-splitter; TG: target; DM: Dichroic mirror. All fiber couplers (blue) have a 50/50 coupling ratio.

Fig. 5
Fig. 5

Retinal imaging at 1.68 MHz axial line rate. More than one million axial scans were acquired in 0.83 s. a) En-face fundus view, reconstructed from the OCT data set. b) Unaveraged B-frame, at the position indicated by the red bar in the en-face view. Media 1 shows an unaveraged flight-through of the entire data set at a playback speed 50 frames per second, i.e. much slower than the OCT acquisition frame rate of 1310 frames per second.

Fig. 6
Fig. 6

a) Multi-data set averaging at 1.68 MHz with the acquire-align-average (AAA) scheme. After acquisition of N data sets, the data sets are aligned and averaged. Thus, distortion per frame is “averaged out” with increasing N. b) Result of AAA approach to imaging at 1.68 MHz. 4 frames from each of the 24 data sets were averaged (i.e. a total of 96 frames) to yield strong speckle reduction. c) Enlarged region from the region indicated by the white frame in b). All retinal layers including the ELM are clearly visible, indicating that alignment worked well. Note that image displayed in the right column of a) is the averaged en-face image after AAA processing of the 24 en-face images. Media 2 shows the en-face reconstructions of all acquired data sets before registration at a playback speed of 2 volumes per second. Slight “zipper” artifacts can be observed due to instabilities in the galvanometer scanners operating at very high speed. A blinking artifact is clearly visible in the first data set.

Fig. 7
Fig. 7

3.35 MHz imaging. a) Reconstructed fundus view, with red horizontal bars indicating the position of the unaveraged B-frames in b,c). As can be seen in c), field of view is not limited by sample arm optics or laser coherence length, but by the sampling rate of the A/D card (and the resulting small imaging range). Media 3 shows only every fifth frame of the data set to reduce the size of the movie. For the movie, frame rate was set to 50/s and aspect ratio was adjusted by 2x downsampling in the horizontal direction. No further averaging was applied.

Fig. 8
Fig. 8

a) 24x and b) 48x average of adjacent B-frames 3.35 MHz axial line rate. Note that, even though the speckle pattern is still partially developed in the 48x averaged image, some anatomical features are already distorted. For instance, the red circle in b) highlights an image detail, which is not visible in the 24x averaged frame. c,d): Enlarged view at the position indicated by the white box in a).

Fig. 9
Fig. 9

Two-beam imaging at an effective axial line rate of 6.7 MHz, using only 0.85 mW optical power for each beam. a) Reconstructed en-face view: White dotted outline shows the area scanned by beam 1. There is around 10% overlap between the areas scanned by the two beams. b,c) B-frames from beams 1 and 2, as indicated by the red bars in the en-face view. The frames were 2x decimated in the transverse direction. d) 6x B-frame average at the same position as the frame shown in c), with enlarged region e).

Tables (1)

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Table 1 Imaging parameters

Equations (1)

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S=10log( ρPT e )IL,

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