Abstract

Despite the development of a large number of promising candidates, few contrast agents for established medical imaging modalities have successfully been translated over the past decade. The emergence of new imaging contrast agents that employ biomedical optics is further complicated by the relative infancy of the field and the lack of approved imaging devices compared to more established clinical modalities such as nuclear medicine. Herein, we propose a navigational approach (as opposed to a fixed “roadmap”) for translation of optical imaging agents that is (i) proposed through consensus by four academic research programs that are part of the cooperative U54 NCI Network for Translational Research, (ii) developed through early experiences for translating optical imaging agents in order to meet distinctly varied needs in cancer diagnostics, and (iii) adaptable to the rapidly changing environment of academic medicine. We describe the pathways by which optical imaging agents are synthesized, qualified, and validated for preclinical testing, and ultimately translated for “first-in-humans” studies using investigational optical imaging devices. By identifying and adopting consensus approaches for seemingly disparate optical imaging modalities and clinical indications, we seek to establish a systematic method for navigating the ever-changing “roadmap” to most efficiently arrive at the destination of clinical adoption and improved outcome and survivorship for cancer patients.

© 2012 OSA

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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  21. H. Lee, W. J. Akers, P. P. Cheney, W. B. Edwards, K. Liang, J. P. Culver, and S. Achilefu, “Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe,” J. Biomed. Opt.14(4), 040507 (2009).
    [CrossRef] [PubMed]
  22. W. B. Edwards, W. J. Akers, Y. Ye, P. P. Cheney, S. Bloch, B. Xu, R. Laforest, and S. Achilefu, “Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide,” Mol. Imaging8(2), 101–110 (2009).
    [PubMed]
  23. J. Culver, W. Akers, and S. Achilefu, “Multimodality molecular imaging with combined optical and SPECT/PET modalities,” J. Nucl. Med.49(2), 169–172 (2008).
    [CrossRef] [PubMed]
  24. J. Kuil, A. H. Velders, and F. W. van Leeuwen, “Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label,” Bioconjug. Chem.21(10), 1709–1719 (2010).
    [CrossRef] [PubMed]
  25. H. G. van der Poel, T. Buckle, O. R. Brouwer, R. A. Valdés Olmos, and F. W. van Leeuwen, “Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer,” Eur. Urol.60(4), 826–833 (2011).
    [CrossRef] [PubMed]
  26. A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, and E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol.14(3), 261–276 (2012).
    [CrossRef] [PubMed]
  27. M. B. Aldrich, M. V. Marshall, E. M. Sevick-Muraca, G. Lanza, J. Kotyk, J. Culver, L. V. Wang, J. Uddin, B. C. Crews, L. J. Marnett, J. C. Liao, C. Contag, J. M. Crawford, K. Wang, B. Reisdorph, H. Appelman, D. K. Turgeon, C. Meyer, and T. Wang, “Seeing it through: translational validation of new medical imaging modalities,” Biomed. Opt. Express3(4), 764–776 (2012).
    [CrossRef] [PubMed]

2012

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

W. J. Akers, W. B. Edwards, C. Kim, B. Xu, T. N. Erpelding, L. V. Wang, and S. Achilefu, “Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography,” Transl. Res.159(3), 175–181 (2012).
[CrossRef] [PubMed]

D. Pan, X. Cai, C. Yalaz, A. Senpan, K. Omanakuttan, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles,” ACS Nano6(2), 1260–1267 (2012).
[CrossRef] [PubMed]

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

M. A. Hall, K. L. Pinkston, N. Wilganowski, H. Robinson, P. Ghosh, A. Azhdarinia, K. Vazquez-Arreguin, A. M. Kolonin, B. R. Harvey, and E. M. Sevick-Muraca, “Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF,” J. Nucl. Med.53(9), 1427–1437 (2012).
[CrossRef] [PubMed]

Y. Zhang, H. Hong, J. W. Engle, Y. Yang, C. P. Theuer, T. E. Barnhart, and W. Cai, “Positron emission tomography and optical imaging of tumor CD105 expression with a dual-labeled monoclonal antibody,” Mol. Pharm.9(3), 645–653 (2012).
[CrossRef] [PubMed]

A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, and E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol.14(3), 261–276 (2012).
[CrossRef] [PubMed]

M. B. Aldrich, M. V. Marshall, E. M. Sevick-Muraca, G. Lanza, J. Kotyk, J. Culver, L. V. Wang, J. Uddin, B. C. Crews, L. J. Marnett, J. C. Liao, C. Contag, J. M. Crawford, K. Wang, B. Reisdorph, H. Appelman, D. K. Turgeon, C. Meyer, and T. Wang, “Seeing it through: translational validation of new medical imaging modalities,” Biomed. Opt. Express3(4), 764–776 (2012).
[CrossRef] [PubMed]

2011

H. G. van der Poel, T. Buckle, O. R. Brouwer, R. A. Valdés Olmos, and F. W. van Leeuwen, “Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer,” Eur. Urol.60(4), 826–833 (2011).
[CrossRef] [PubMed]

J. T. Liu, N. O. Loewke, M. J. Mandella, R. M. Levenson, J. M. Crawford, and C. H. Contag, “Point-of-care pathology with miniature microscopes,” Anal Cell Pathol (Amst)34(3), 81–98 (2011).
[PubMed]

D. A. Ostrov and C. H. Contag, “Molecular imaging of inflammation and carcinogenesis,” Cancer Prev. Res. (Phila.)4(10), 1523–1526 (2011).
[CrossRef] [PubMed]

D. Pan, M. Pramanik, A. Senpan, J. S. Allen, H. Zhang, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons,” FASEB J.25(3), 875–882 (2011).
[CrossRef] [PubMed]

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

2010

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

M. Goetz and T. D. Wang, “Molecular imaging in gastrointestinal endoscopy,” Gastroenterology138(3), 828–833.e1 (2010).
[CrossRef] [PubMed]

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–217 (2010).
[PubMed]

J. Kuil, A. H. Velders, and F. W. van Leeuwen, “Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label,” Bioconjug. Chem.21(10), 1709–1719 (2010).
[CrossRef] [PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

2009

H. Lee, W. J. Akers, P. P. Cheney, W. B. Edwards, K. Liang, J. P. Culver, and S. Achilefu, “Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe,” J. Biomed. Opt.14(4), 040507 (2009).
[CrossRef] [PubMed]

W. B. Edwards, W. J. Akers, Y. Ye, P. P. Cheney, S. Bloch, B. Xu, R. Laforest, and S. Achilefu, “Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide,” Mol. Imaging8(2), 101–110 (2009).
[PubMed]

2008

J. Culver, W. Akers, and S. Achilefu, “Multimodality molecular imaging with combined optical and SPECT/PET modalities,” J. Nucl. Med.49(2), 169–172 (2008).
[CrossRef] [PubMed]

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

2005

J. P. Houston, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probe,” J. Biomed. Opt.10(5), 054010 (2005).
[CrossRef] [PubMed]

Achilefu, S.

W. J. Akers, W. B. Edwards, C. Kim, B. Xu, T. N. Erpelding, L. V. Wang, and S. Achilefu, “Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography,” Transl. Res.159(3), 175–181 (2012).
[CrossRef] [PubMed]

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

H. Lee, W. J. Akers, P. P. Cheney, W. B. Edwards, K. Liang, J. P. Culver, and S. Achilefu, “Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe,” J. Biomed. Opt.14(4), 040507 (2009).
[CrossRef] [PubMed]

W. B. Edwards, W. J. Akers, Y. Ye, P. P. Cheney, S. Bloch, B. Xu, R. Laforest, and S. Achilefu, “Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide,” Mol. Imaging8(2), 101–110 (2009).
[PubMed]

J. Culver, W. Akers, and S. Achilefu, “Multimodality molecular imaging with combined optical and SPECT/PET modalities,” J. Nucl. Med.49(2), 169–172 (2008).
[CrossRef] [PubMed]

Adams, K. E.

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

Akers, W.

J. Culver, W. Akers, and S. Achilefu, “Multimodality molecular imaging with combined optical and SPECT/PET modalities,” J. Nucl. Med.49(2), 169–172 (2008).
[CrossRef] [PubMed]

Akers, W. J.

W. J. Akers, W. B. Edwards, C. Kim, B. Xu, T. N. Erpelding, L. V. Wang, and S. Achilefu, “Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography,” Transl. Res.159(3), 175–181 (2012).
[CrossRef] [PubMed]

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

W. B. Edwards, W. J. Akers, Y. Ye, P. P. Cheney, S. Bloch, B. Xu, R. Laforest, and S. Achilefu, “Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide,” Mol. Imaging8(2), 101–110 (2009).
[PubMed]

H. Lee, W. J. Akers, P. P. Cheney, W. B. Edwards, K. Liang, J. P. Culver, and S. Achilefu, “Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe,” J. Biomed. Opt.14(4), 040507 (2009).
[CrossRef] [PubMed]

Aldrich, M. B.

Allen, J. S.

D. Pan, M. Pramanik, A. Senpan, J. S. Allen, H. Zhang, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons,” FASEB J.25(3), 875–882 (2011).
[CrossRef] [PubMed]

Appelman, H.

Azhdarinia, A.

A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, and E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol.14(3), 261–276 (2012).
[CrossRef] [PubMed]

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

M. A. Hall, K. L. Pinkston, N. Wilganowski, H. Robinson, P. Ghosh, A. Azhdarinia, K. Vazquez-Arreguin, A. M. Kolonin, B. R. Harvey, and E. M. Sevick-Muraca, “Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF,” J. Nucl. Med.53(9), 1427–1437 (2012).
[CrossRef] [PubMed]

Barnhart, T. E.

Y. Zhang, H. Hong, J. W. Engle, Y. Yang, C. P. Theuer, T. E. Barnhart, and W. Cai, “Positron emission tomography and optical imaging of tumor CD105 expression with a dual-labeled monoclonal antibody,” Mol. Pharm.9(3), 645–653 (2012).
[CrossRef] [PubMed]

Berezin, M.

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

Blobaum, A. L.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Bloch, S.

W. B. Edwards, W. J. Akers, Y. Ye, P. P. Cheney, S. Bloch, B. Xu, R. Laforest, and S. Achilefu, “Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide,” Mol. Imaging8(2), 101–110 (2009).
[PubMed]

Brouwer, O. R.

H. G. van der Poel, T. Buckle, O. R. Brouwer, R. A. Valdés Olmos, and F. W. van Leeuwen, “Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer,” Eur. Urol.60(4), 826–833 (2011).
[CrossRef] [PubMed]

Buckle, T.

H. G. van der Poel, T. Buckle, O. R. Brouwer, R. A. Valdés Olmos, and F. W. van Leeuwen, “Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer,” Eur. Urol.60(4), 826–833 (2011).
[CrossRef] [PubMed]

Cai, W.

Y. Zhang, H. Hong, J. W. Engle, Y. Yang, C. P. Theuer, T. E. Barnhart, and W. Cai, “Positron emission tomography and optical imaging of tumor CD105 expression with a dual-labeled monoclonal antibody,” Mol. Pharm.9(3), 645–653 (2012).
[CrossRef] [PubMed]

Cai, X.

D. Pan, X. Cai, C. Yalaz, A. Senpan, K. Omanakuttan, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles,” ACS Nano6(2), 1260–1267 (2012).
[CrossRef] [PubMed]

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

Chan, W.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

Cheney, P. P.

H. Lee, W. J. Akers, P. P. Cheney, W. B. Edwards, K. Liang, J. P. Culver, and S. Achilefu, “Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe,” J. Biomed. Opt.14(4), 040507 (2009).
[CrossRef] [PubMed]

W. B. Edwards, W. J. Akers, Y. Ye, P. P. Cheney, S. Bloch, B. Xu, R. Laforest, and S. Achilefu, “Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide,” Mol. Imaging8(2), 101–110 (2009).
[PubMed]

Contag, C.

Contag, C. H.

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

J. T. Liu, N. O. Loewke, M. J. Mandella, R. M. Levenson, J. M. Crawford, and C. H. Contag, “Point-of-care pathology with miniature microscopes,” Anal Cell Pathol (Amst)34(3), 81–98 (2011).
[PubMed]

D. A. Ostrov and C. H. Contag, “Molecular imaging of inflammation and carcinogenesis,” Cancer Prev. Res. (Phila.)4(10), 1523–1526 (2011).
[CrossRef] [PubMed]

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Crawford, J. M.

M. B. Aldrich, M. V. Marshall, E. M. Sevick-Muraca, G. Lanza, J. Kotyk, J. Culver, L. V. Wang, J. Uddin, B. C. Crews, L. J. Marnett, J. C. Liao, C. Contag, J. M. Crawford, K. Wang, B. Reisdorph, H. Appelman, D. K. Turgeon, C. Meyer, and T. Wang, “Seeing it through: translational validation of new medical imaging modalities,” Biomed. Opt. Express3(4), 764–776 (2012).
[CrossRef] [PubMed]

J. T. Liu, N. O. Loewke, M. J. Mandella, R. M. Levenson, J. M. Crawford, and C. H. Contag, “Point-of-care pathology with miniature microscopes,” Anal Cell Pathol (Amst)34(3), 81–98 (2011).
[PubMed]

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Crews, B. C.

M. B. Aldrich, M. V. Marshall, E. M. Sevick-Muraca, G. Lanza, J. Kotyk, J. Culver, L. V. Wang, J. Uddin, B. C. Crews, L. J. Marnett, J. C. Liao, C. Contag, J. M. Crawford, K. Wang, B. Reisdorph, H. Appelman, D. K. Turgeon, C. Meyer, and T. Wang, “Seeing it through: translational validation of new medical imaging modalities,” Biomed. Opt. Express3(4), 764–776 (2012).
[CrossRef] [PubMed]

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Culver, J.

Culver, J. P.

H. Lee, W. J. Akers, P. P. Cheney, W. B. Edwards, K. Liang, J. P. Culver, and S. Achilefu, “Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe,” J. Biomed. Opt.14(4), 040507 (2009).
[CrossRef] [PubMed]

Daltrozzo, E.

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

Dannenberg, A. J.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Darne, C.

Du, C. B.

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Edwards, W. B.

W. J. Akers, W. B. Edwards, C. Kim, B. Xu, T. N. Erpelding, L. V. Wang, and S. Achilefu, “Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography,” Transl. Res.159(3), 175–181 (2012).
[CrossRef] [PubMed]

H. Lee, W. J. Akers, P. P. Cheney, W. B. Edwards, K. Liang, J. P. Culver, and S. Achilefu, “Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe,” J. Biomed. Opt.14(4), 040507 (2009).
[CrossRef] [PubMed]

W. B. Edwards, W. J. Akers, Y. Ye, P. P. Cheney, S. Bloch, B. Xu, R. Laforest, and S. Achilefu, “Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide,” Mol. Imaging8(2), 101–110 (2009).
[PubMed]

Engle, J. W.

Y. Zhang, H. Hong, J. W. Engle, Y. Yang, C. P. Theuer, T. E. Barnhart, and W. Cai, “Positron emission tomography and optical imaging of tumor CD105 expression with a dual-labeled monoclonal antibody,” Mol. Pharm.9(3), 645–653 (2012).
[CrossRef] [PubMed]

Erpelding, T. N.

W. J. Akers, W. B. Edwards, C. Kim, B. Xu, T. N. Erpelding, L. V. Wang, and S. Achilefu, “Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography,” Transl. Res.159(3), 175–181 (2012).
[CrossRef] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

Fife, C. E.

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

Fischer, G. M.

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

Friedland, S.

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Fuhrhop, R.

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

Ghosh, P.

M. A. Hall, K. L. Pinkston, N. Wilganowski, H. Robinson, P. Ghosh, A. Azhdarinia, K. Vazquez-Arreguin, A. M. Kolonin, B. R. Harvey, and E. M. Sevick-Muraca, “Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF,” J. Nucl. Med.53(9), 1427–1437 (2012).
[CrossRef] [PubMed]

A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, and E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol.14(3), 261–276 (2012).
[CrossRef] [PubMed]

Ghosh, S.

A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, and E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol.14(3), 261–276 (2012).
[CrossRef] [PubMed]

Goetz, M.

M. Goetz and T. D. Wang, “Molecular imaging in gastrointestinal endoscopy,” Gastroenterology138(3), 828–833.e1 (2010).
[CrossRef] [PubMed]

Gorden, D. L.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Guilloid, R.

Guo, K.

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

Hall, M. A.

M. A. Hall, K. L. Pinkston, N. Wilganowski, H. Robinson, P. Ghosh, A. Azhdarinia, K. Vazquez-Arreguin, A. M. Kolonin, B. R. Harvey, and E. M. Sevick-Muraca, “Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF,” J. Nucl. Med.53(9), 1427–1437 (2012).
[CrossRef] [PubMed]

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–217 (2010).
[PubMed]

Hardy, J.

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Harvey, B. R.

M. A. Hall, K. L. Pinkston, N. Wilganowski, H. Robinson, P. Ghosh, A. Azhdarinia, K. Vazquez-Arreguin, A. M. Kolonin, B. R. Harvey, and E. M. Sevick-Muraca, “Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF,” J. Nucl. Med.53(9), 1427–1437 (2012).
[CrossRef] [PubMed]

Hong, H.

Y. Zhang, H. Hong, J. W. Engle, Y. Yang, C. P. Theuer, T. E. Barnhart, and W. Cai, “Positron emission tomography and optical imaging of tumor CD105 expression with a dual-labeled monoclonal antibody,” Mol. Pharm.9(3), 645–653 (2012).
[CrossRef] [PubMed]

Houston, J. P.

J. P. Houston, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probe,” J. Biomed. Opt.10(5), 054010 (2005).
[CrossRef] [PubMed]

Hoy, S.

Hsiung, P. L.

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Hu, S.

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

Jankovic, L.

Ke, S.

J. P. Houston, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probe,” J. Biomed. Opt.10(5), 054010 (2005).
[CrossRef] [PubMed]

Kim, C.

W. J. Akers, W. B. Edwards, C. Kim, B. Xu, T. N. Erpelding, L. V. Wang, and S. Achilefu, “Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography,” Transl. Res.159(3), 175–181 (2012).
[CrossRef] [PubMed]

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

Kingsley, P. J.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Kino, G. S.

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

Kolonin, A. M.

M. A. Hall, K. L. Pinkston, N. Wilganowski, H. Robinson, P. Ghosh, A. Azhdarinia, K. Vazquez-Arreguin, A. M. Kolonin, B. R. Harvey, and E. M. Sevick-Muraca, “Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF,” J. Nucl. Med.53(9), 1427–1437 (2012).
[CrossRef] [PubMed]

Kotyk, J.

Kuil, J.

J. Kuil, A. H. Velders, and F. W. van Leeuwen, “Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label,” Bioconjug. Chem.21(10), 1709–1719 (2010).
[CrossRef] [PubMed]

Kwon, S.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–217 (2010).
[PubMed]

Lachance, P. A.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

Laforest, R.

W. B. Edwards, W. J. Akers, Y. Ye, P. P. Cheney, S. Bloch, B. Xu, R. Laforest, and S. Achilefu, “Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide,” Mol. Imaging8(2), 101–110 (2009).
[PubMed]

Lanza, G.

Lanza, G. M.

D. Pan, X. Cai, C. Yalaz, A. Senpan, K. Omanakuttan, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles,” ACS Nano6(2), 1260–1267 (2012).
[CrossRef] [PubMed]

D. Pan, M. Pramanik, A. Senpan, J. S. Allen, H. Zhang, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons,” FASEB J.25(3), 875–882 (2011).
[CrossRef] [PubMed]

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

Lee, H.

H. Lee, W. J. Akers, P. P. Cheney, W. B. Edwards, K. Liang, J. P. Culver, and S. Achilefu, “Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe,” J. Biomed. Opt.14(4), 040507 (2009).
[CrossRef] [PubMed]

Levenson, R. M.

J. T. Liu, N. O. Loewke, M. J. Mandella, R. M. Levenson, J. M. Crawford, and C. H. Contag, “Point-of-care pathology with miniature microscopes,” Anal Cell Pathol (Amst)34(3), 81–98 (2011).
[PubMed]

Li, C.

J. P. Houston, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probe,” J. Biomed. Opt.10(5), 054010 (2005).
[CrossRef] [PubMed]

Liang, K.

H. Lee, W. J. Akers, P. P. Cheney, W. B. Edwards, K. Liang, J. P. Culver, and S. Achilefu, “Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe,” J. Biomed. Opt.14(4), 040507 (2009).
[CrossRef] [PubMed]

Liao, J. C.

Liu, J. T.

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

J. T. Liu, N. O. Loewke, M. J. Mandella, R. M. Levenson, J. M. Crawford, and C. H. Contag, “Point-of-care pathology with miniature microscopes,” Anal Cell Pathol (Amst)34(3), 81–98 (2011).
[PubMed]

Loewke, K.

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

Loewke, N. O.

J. T. Liu, N. O. Loewke, M. J. Mandella, R. M. Levenson, J. M. Crawford, and C. H. Contag, “Point-of-care pathology with miniature microscopes,” Anal Cell Pathol (Amst)34(3), 81–98 (2011).
[PubMed]

Lowe, A. W.

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Mandella, M. J.

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

J. T. Liu, N. O. Loewke, M. J. Mandella, R. M. Levenson, J. M. Crawford, and C. H. Contag, “Point-of-care pathology with miniature microscopes,” Anal Cell Pathol (Amst)34(3), 81–98 (2011).
[PubMed]

Marnett, L. J.

M. B. Aldrich, M. V. Marshall, E. M. Sevick-Muraca, G. Lanza, J. Kotyk, J. Culver, L. V. Wang, J. Uddin, B. C. Crews, L. J. Marnett, J. C. Liao, C. Contag, J. M. Crawford, K. Wang, B. Reisdorph, H. Appelman, D. K. Turgeon, C. Meyer, and T. Wang, “Seeing it through: translational validation of new medical imaging modalities,” Biomed. Opt. Express3(4), 764–776 (2012).
[CrossRef] [PubMed]

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Marshall, M. V.

Matrisian, L. M.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Maus, E. A.

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

McIntyre, J. O.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Meyer, C.

Omanakuttan, K.

D. Pan, X. Cai, C. Yalaz, A. Senpan, K. Omanakuttan, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles,” ACS Nano6(2), 1260–1267 (2012).
[CrossRef] [PubMed]

Ostrov, D. A.

D. A. Ostrov and C. H. Contag, “Molecular imaging of inflammation and carcinogenesis,” Cancer Prev. Res. (Phila.)4(10), 1523–1526 (2011).
[CrossRef] [PubMed]

Pan, D.

D. Pan, X. Cai, C. Yalaz, A. Senpan, K. Omanakuttan, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles,” ACS Nano6(2), 1260–1267 (2012).
[CrossRef] [PubMed]

D. Pan, M. Pramanik, A. Senpan, J. S. Allen, H. Zhang, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons,” FASEB J.25(3), 875–882 (2011).
[CrossRef] [PubMed]

Pashley, M. D.

Pinkston, K. L.

M. A. Hall, K. L. Pinkston, N. Wilganowski, H. Robinson, P. Ghosh, A. Azhdarinia, K. Vazquez-Arreguin, A. M. Kolonin, B. R. Harvey, and E. M. Sevick-Muraca, “Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF,” J. Nucl. Med.53(9), 1427–1437 (2012).
[CrossRef] [PubMed]

Piston, D. W.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Piyawattanametha, W.

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

Pramanik, M.

D. Pan, M. Pramanik, A. Senpan, J. S. Allen, H. Zhang, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons,” FASEB J.25(3), 875–882 (2011).
[CrossRef] [PubMed]

Price, R. E.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–217 (2010).
[PubMed]

Qiu, Z.

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

Ra, H.

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

Ranganathan, R.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

Rasmussen, J. C.

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

Reisdorph, B.

Robinson, H.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

M. A. Hall, K. L. Pinkston, N. Wilganowski, H. Robinson, P. Ghosh, A. Azhdarinia, K. Vazquez-Arreguin, A. M. Kolonin, B. R. Harvey, and E. M. Sevick-Muraca, “Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF,” J. Nucl. Med.53(9), 1427–1437 (2012).
[CrossRef] [PubMed]

Sahbaie, P.

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Sampath, L.

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–217 (2010).
[PubMed]

Senpan, A.

D. Pan, X. Cai, C. Yalaz, A. Senpan, K. Omanakuttan, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles,” ACS Nano6(2), 1260–1267 (2012).
[CrossRef] [PubMed]

D. Pan, M. Pramanik, A. Senpan, J. S. Allen, H. Zhang, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons,” FASEB J.25(3), 875–882 (2011).
[CrossRef] [PubMed]

Sevick-Muraca, E. M.

M. A. Hall, K. L. Pinkston, N. Wilganowski, H. Robinson, P. Ghosh, A. Azhdarinia, K. Vazquez-Arreguin, A. M. Kolonin, B. R. Harvey, and E. M. Sevick-Muraca, “Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF,” J. Nucl. Med.53(9), 1427–1437 (2012).
[CrossRef] [PubMed]

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

M. B. Aldrich, M. V. Marshall, E. M. Sevick-Muraca, G. Lanza, J. Kotyk, J. Culver, L. V. Wang, J. Uddin, B. C. Crews, L. J. Marnett, J. C. Liao, C. Contag, J. M. Crawford, K. Wang, B. Reisdorph, H. Appelman, D. K. Turgeon, C. Meyer, and T. Wang, “Seeing it through: translational validation of new medical imaging modalities,” Biomed. Opt. Express3(4), 764–776 (2012).
[CrossRef] [PubMed]

A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, and E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol.14(3), 261–276 (2012).
[CrossRef] [PubMed]

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–217 (2010).
[PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

J. P. Houston, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probe,” J. Biomed. Opt.10(5), 054010 (2005).
[CrossRef] [PubMed]

Smith, L. A.

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

Soetikno, R.

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Solgaard, O.

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

Subbaramaiah, K.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Tan, I. C.

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

Theuer, C. P.

Y. Zhang, H. Hong, J. W. Engle, Y. Yang, C. P. Theuer, T. E. Barnhart, and W. Cai, “Positron emission tomography and optical imaging of tumor CD105 expression with a dual-labeled monoclonal antibody,” Mol. Pharm.9(3), 645–653 (2012).
[CrossRef] [PubMed]

Turgeon, D. K.

Uddin, J.

Uddin, M. J.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Valdés Olmos, R. A.

H. G. van der Poel, T. Buckle, O. R. Brouwer, R. A. Valdés Olmos, and F. W. van Leeuwen, “Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer,” Eur. Urol.60(4), 826–833 (2011).
[CrossRef] [PubMed]

van der Poel, H. G.

H. G. van der Poel, T. Buckle, O. R. Brouwer, R. A. Valdés Olmos, and F. W. van Leeuwen, “Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer,” Eur. Urol.60(4), 826–833 (2011).
[CrossRef] [PubMed]

van Leeuwen, F. W.

H. G. van der Poel, T. Buckle, O. R. Brouwer, R. A. Valdés Olmos, and F. W. van Leeuwen, “Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer,” Eur. Urol.60(4), 826–833 (2011).
[CrossRef] [PubMed]

J. Kuil, A. H. Velders, and F. W. van Leeuwen, “Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label,” Bioconjug. Chem.21(10), 1709–1719 (2010).
[CrossRef] [PubMed]

Vazquez-Arreguin, K.

M. A. Hall, K. L. Pinkston, N. Wilganowski, H. Robinson, P. Ghosh, A. Azhdarinia, K. Vazquez-Arreguin, A. M. Kolonin, B. R. Harvey, and E. M. Sevick-Muraca, “Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF,” J. Nucl. Med.53(9), 1427–1437 (2012).
[CrossRef] [PubMed]

Velders, A. H.

J. Kuil, A. H. Velders, and F. W. van Leeuwen, “Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label,” Bioconjug. Chem.21(10), 1709–1719 (2010).
[CrossRef] [PubMed]

Wang, K.

Wang, L. V.

M. B. Aldrich, M. V. Marshall, E. M. Sevick-Muraca, G. Lanza, J. Kotyk, J. Culver, L. V. Wang, J. Uddin, B. C. Crews, L. J. Marnett, J. C. Liao, C. Contag, J. M. Crawford, K. Wang, B. Reisdorph, H. Appelman, D. K. Turgeon, C. Meyer, and T. Wang, “Seeing it through: translational validation of new medical imaging modalities,” Biomed. Opt. Express3(4), 764–776 (2012).
[CrossRef] [PubMed]

D. Pan, X. Cai, C. Yalaz, A. Senpan, K. Omanakuttan, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles,” ACS Nano6(2), 1260–1267 (2012).
[CrossRef] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

W. J. Akers, W. B. Edwards, C. Kim, B. Xu, T. N. Erpelding, L. V. Wang, and S. Achilefu, “Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography,” Transl. Res.159(3), 175–181 (2012).
[CrossRef] [PubMed]

D. Pan, M. Pramanik, A. Senpan, J. S. Allen, H. Zhang, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons,” FASEB J.25(3), 875–882 (2011).
[CrossRef] [PubMed]

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

Wang, T.

Wang, T. D.

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

M. Goetz and T. D. Wang, “Molecular imaging in gastrointestinal endoscopy,” Gastroenterology138(3), 828–833.e1 (2010).
[CrossRef] [PubMed]

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Wang, W.

J. P. Houston, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probe,” J. Biomed. Opt.10(5), 054010 (2005).
[CrossRef] [PubMed]

Wickline, S. A.

D. Pan, X. Cai, C. Yalaz, A. Senpan, K. Omanakuttan, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles,” ACS Nano6(2), 1260–1267 (2012).
[CrossRef] [PubMed]

D. Pan, M. Pramanik, A. Senpan, J. S. Allen, H. Zhang, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons,” FASEB J.25(3), 875–882 (2011).
[CrossRef] [PubMed]

Wilganowski, N.

M. A. Hall, K. L. Pinkston, N. Wilganowski, H. Robinson, P. Ghosh, A. Azhdarinia, K. Vazquez-Arreguin, A. M. Kolonin, B. R. Harvey, and E. M. Sevick-Muraca, “Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF,” J. Nucl. Med.53(9), 1427–1437 (2012).
[CrossRef] [PubMed]

A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, and E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol.14(3), 261–276 (2012).
[CrossRef] [PubMed]

Wu, A. P.

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Xu, B.

W. J. Akers, W. B. Edwards, C. Kim, B. Xu, T. N. Erpelding, L. V. Wang, and S. Achilefu, “Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography,” Transl. Res.159(3), 175–181 (2012).
[CrossRef] [PubMed]

W. B. Edwards, W. J. Akers, Y. Ye, P. P. Cheney, S. Bloch, B. Xu, R. Laforest, and S. Achilefu, “Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide,” Mol. Imaging8(2), 101–110 (2009).
[PubMed]

Yalaz, C.

D. Pan, X. Cai, C. Yalaz, A. Senpan, K. Omanakuttan, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles,” ACS Nano6(2), 1260–1267 (2012).
[CrossRef] [PubMed]

Yang, Y.

Y. Zhang, H. Hong, J. W. Engle, Y. Yang, C. P. Theuer, T. E. Barnhart, and W. Cai, “Positron emission tomography and optical imaging of tumor CD105 expression with a dual-labeled monoclonal antibody,” Mol. Pharm.9(3), 645–653 (2012).
[CrossRef] [PubMed]

Ye, Y.

W. B. Edwards, W. J. Akers, Y. Ye, P. P. Cheney, S. Bloch, B. Xu, R. Laforest, and S. Achilefu, “Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide,” Mol. Imaging8(2), 101–110 (2009).
[PubMed]

Zhang, H.

D. Pan, M. Pramanik, A. Senpan, J. S. Allen, H. Zhang, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons,” FASEB J.25(3), 875–882 (2011).
[CrossRef] [PubMed]

Zhang, Y.

Y. Zhang, H. Hong, J. W. Engle, Y. Yang, C. P. Theuer, T. E. Barnhart, and W. Cai, “Positron emission tomography and optical imaging of tumor CD105 expression with a dual-labeled monoclonal antibody,” Mol. Pharm.9(3), 645–653 (2012).
[CrossRef] [PubMed]

Zumbusch, A.

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

ACS Nano

W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano5(1), 173–182 (2011).
[CrossRef] [PubMed]

D. Pan, X. Cai, C. Yalaz, A. Senpan, K. Omanakuttan, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles,” ACS Nano6(2), 1260–1267 (2012).
[CrossRef] [PubMed]

Anal Cell Pathol (Amst)

J. T. Liu, N. O. Loewke, M. J. Mandella, R. M. Levenson, J. M. Crawford, and C. H. Contag, “Point-of-care pathology with miniature microscopes,” Anal Cell Pathol (Amst)34(3), 81–98 (2011).
[PubMed]

Arch. Phys. Med. Rehabil.

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

Bioconjug. Chem.

J. Kuil, A. H. Velders, and F. W. van Leeuwen, “Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label,” Bioconjug. Chem.21(10), 1709–1719 (2010).
[CrossRef] [PubMed]

Biomed. Opt. Express

Cancer Prev. Res. (Phila.)

D. A. Ostrov and C. H. Contag, “Molecular imaging of inflammation and carcinogenesis,” Cancer Prev. Res. (Phila.)4(10), 1523–1526 (2011).
[CrossRef] [PubMed]

Cancer Res.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Eur. Urol.

H. G. van der Poel, T. Buckle, O. R. Brouwer, R. A. Valdés Olmos, and F. W. van Leeuwen, “Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer,” Eur. Urol.60(4), 826–833 (2011).
[CrossRef] [PubMed]

FASEB J.

D. Pan, M. Pramanik, A. Senpan, J. S. Allen, H. Zhang, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons,” FASEB J.25(3), 875–882 (2011).
[CrossRef] [PubMed]

Gastroenterology

M. Goetz and T. D. Wang, “Molecular imaging in gastrointestinal endoscopy,” Gastroenterology138(3), 828–833.e1 (2010).
[CrossRef] [PubMed]

J. Biomed. Opt.

W. Piyawattanametha, H. Ra, Z. Qiu, S. Friedland, J. T. Liu, K. Loewke, G. S. Kino, O. Solgaard, T. D. Wang, M. J. Mandella, and C. H. Contag, “In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract,” J. Biomed. Opt.17(2), 021102 (2012).
[CrossRef] [PubMed]

J. P. Houston, S. Ke, W. Wang, C. Li, and E. M. Sevick-Muraca, “Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probe,” J. Biomed. Opt.10(5), 054010 (2005).
[CrossRef] [PubMed]

H. Lee, W. J. Akers, P. P. Cheney, W. B. Edwards, K. Liang, J. P. Culver, and S. Achilefu, “Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe,” J. Biomed. Opt.14(4), 040507 (2009).
[CrossRef] [PubMed]

J. Nucl. Med.

M. A. Hall, K. L. Pinkston, N. Wilganowski, H. Robinson, P. Ghosh, A. Azhdarinia, K. Vazquez-Arreguin, A. M. Kolonin, B. R. Harvey, and E. M. Sevick-Muraca, “Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF,” J. Nucl. Med.53(9), 1427–1437 (2012).
[CrossRef] [PubMed]

J. Culver, W. Akers, and S. Achilefu, “Multimodality molecular imaging with combined optical and SPECT/PET modalities,” J. Nucl. Med.49(2), 169–172 (2008).
[CrossRef] [PubMed]

Mol. Imaging

W. B. Edwards, W. J. Akers, Y. Ye, P. P. Cheney, S. Bloch, B. Xu, R. Laforest, and S. Achilefu, “Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide,” Mol. Imaging8(2), 101–110 (2009).
[PubMed]

Mol. Imaging Biol.

A. Azhdarinia, P. Ghosh, S. Ghosh, N. Wilganowski, and E. M. Sevick-Muraca, “Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis,” Mol. Imaging Biol.14(3), 261–276 (2012).
[CrossRef] [PubMed]

Mol. Pharm.

Y. Zhang, H. Hong, J. W. Engle, Y. Yang, C. P. Theuer, T. E. Barnhart, and W. Cai, “Positron emission tomography and optical imaging of tumor CD105 expression with a dual-labeled monoclonal antibody,” Mol. Pharm.9(3), 645–653 (2012).
[CrossRef] [PubMed]

Nat. Med.

P. L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Prostate

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

Science

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

Transl Oncol

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–217 (2010).
[PubMed]

Transl. Res.

W. J. Akers, W. B. Edwards, C. Kim, B. Xu, T. N. Erpelding, L. V. Wang, and S. Achilefu, “Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography,” Transl. Res.159(3), 175–181 (2012).
[CrossRef] [PubMed]

Other

Z. Liu, S. J. Miller, B. P. Joshi, and T. D. Wang, “In vivo targeting of colonic dysplasia on fluorescence endoscopy with near-infrared octapeptide,” Gut, 17 March 2012, http://gut.bmj.com/content/early/2012/03/16/gutjnl-2011-301913.abstract .

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Figures (5)

Fig. 1
Fig. 1

Pathways for developing and validating a molecular imaging agent (BD = biodistribution).

Fig. 2
Fig. 2

Screening and development of the COX-2 targeted agent, fluorocoxib by SU/VU.

Fig. 3
Fig. 3

Flowchart for screening, selection, preparation, and characterization of fluorescent peptide probes at UM.

Fig. 4
Fig. 4

Flowchart for synthesis and characterization multimodal agents for SLN mapping by WUSTL.

Fig. 5
Fig. 5

Flowchart for preparation and characterization of fluorescent and dual-labeled mAbs by UTHSC. (D/P = dye/protein ratio, QC = quality control).

Tables (1)

Tables Icon

Table 1 Overview of NTR teams and research strategies

Metrics