Abstract

In this work, photoinduced delayed luminescence (DL) was used to distinguish serum samples of patients with acute lymphoblastic leukemia from those of healthy volunteers. DL decay kinetics of human serum samples was measured using a homebuilt ultraweak luminescence detection system. It was found a significant difference in the weight distribution of the decay rate between normal and leukemic serum samples. A comparison of the DL kinetics parameters including the initial intensity, the peak decay rate, and the peak weight value was used in making discrimination between normal and leukemic human sera. Results in this work contribute to the development of a novel optical method for the early diagnosis of leukemia.

© 2012 OSA

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  24. The definition of p-value can be found at http://en.wikipedia.org/wiki/P-value .

2011 (2)

2010 (1)

2009 (1)

H. Bai, P. Chen, L. Lin, S. J. Chang, G. Q. Tang, and G. G. Mu, “Physical mechanism of delayed luminescence from human serum,” Proc. SPIE7182, 71820K, 71820K-10 (2009).
[CrossRef]

2008 (2)

E. Costanzo, M. Gulino, L. Lanzanò, F. Musumeci, A. Scordino, S. Tudisco, and L. Sui, “Single seed viability checked by delayed luminescence,” Eur. Biophys. J.37(2), 235–238 (2008).
[CrossRef] [PubMed]

X. D. Zhang, J. F. Li, Q. Q. Zhao, L. Zhang, and C. Pan, “The study on absorption spectrum of leukaemia's serum,” Laser & Infrared38, 267–269 (2008).

2007 (2)

L. Lanzanò, A. Scordino, S. Privitera, S. Tudisco, and F. Musumeci, “Spectral analysis of Delayed Luminescence from human skin as a possible non-invasive diagnostic tool,” Eur. Biophys. J.36(7), 823–829 (2007).
[CrossRef] [PubMed]

D. H. Qi and A. J. Berger, “Chemical concentration measurement in blood serum and urine samples using liquid-core optical fiber Raman spectroscopy,” Appl. Opt.46(10), 1726–1734 (2007).
[CrossRef] [PubMed]

2006 (2)

F. Erdem, M. Gundogdu, and A. Kiziltunc, “Serum vascular endothelial growth factor level in patients with hematological malignancies,” Eur. J. Gen. Med.3, 116–120 (2006).

C. G. L. Canellas, S. M. F. Carvalho, E. F. O. De Jesus, M. J. Anjos, and R. T. Lopes, “Trace and major elements in serum of patients with chronic myelogenous leukemia,” J. Radioanal. Nucl. Chem.269(3), 631–634 (2006).
[CrossRef]

2005 (5)

Y. Yan, F. A. Popp, S. Sigrist, D. Schlesinger, A. Dolf, Z. C. Yan, S. Cohen, and A. Chotia, “Further analysis of delayed luminescence of plants,” J. Photochem. Photobiol. B78(3), 235–244 (2005).
[CrossRef] [PubMed]

J. Kim, J. Lim, B. C. Lee, Y. U. Kim, S. K. Lee, B. S. Cheun, and K. S. Soh, “Spontaneous ultra-weak photon emission and delayed luminescence during carbon tetrachloride-induced liver injury and repair in mouse,” J. Health Sci.51(2), 155–160 (2005).
[CrossRef]

H. W. Kim, S. B. Sim, C. K. Kim, J. Kim, C. H. Choi, H. R. You, and K. S. Soh, “Spontaneous photon emission and delayed luminescence of two types of human lung cancer tissues: adenocarcinoma and squamous cell carcinoma,” Cancer Lett.229(2), 283–289 (2005).
[CrossRef] [PubMed]

F. Musumeci, L. A. Applegate, G. Privitera, A. Scordino, S. Tudisco, and H. J. Niggli, “Spectral analysis of laser-induced ultraweak delayed luminescence in cultured normal and tumor human cells: temperature dependence,” J. Photochem. Photobiol. B79(2), 93–99 (2005).
[CrossRef] [PubMed]

C. L. Wang, D. Xing, L. Z. Zeng, C. F. Ding, and Q. Chen, “Effect of artificial acid rain and SO2 on characteristics of delayed light emission,” Luminescence20(1), 51–56 (2005).
[CrossRef] [PubMed]

2003 (2)

S. Tudisco, F. Musumeci, A. Scordino, and G. Privitera, “Advanced research equipment for fast ultraweak luminescence analysis,” Rev. Sci. Instrum.74(10), 4485–4490 (2003).
[CrossRef]

S. Madhuri, N. Vengadesan, P. Aruna, D. Koteeswaran, P. Venkatesan, and S. Ganesan, “Native fluorescence spectroscopy of blood plasma in the characterization of oral malignancy,” Photochem. Photobiol.78(2), 197–204 (2003).
[CrossRef] [PubMed]

2002 (1)

F. A. Popp and Y. Yan, “Delayed luminescence of biological systems in terms of coherent states,” Phys. Lett. A293(1-2), 93–97 (2002).
[CrossRef]

2000 (1)

A. Scordino, A. Triglia, and F. Musumeci, “Analogous features of delayed luminescence from Acetabularia acetabulum and some solid state systems,” J. Photochem. Photobiol. B56(2-3), 181–186 (2000).
[CrossRef] [PubMed]

1999 (1)

T. F. Raichenok, “Luminescence of human blood serum in the longwave spectral region,” J. Appl. Spectrosc.66(3), 470–472 (1999).
[CrossRef]

1987 (1)

M. E. Rollie, G. Patonay, and I. M. Warner, “Automated sample deoxygenation for improved luminescence measurements,” Anal. Chem.59(1), 180–184 (1987).
[CrossRef]

1985 (1)

O. S. Wolfbeis and M. Leiner, “Mapping of the total fluorescence of human blood serum as a new method for its characterization,” Anal. Chim. Acta167, 203–215 (1985).
[CrossRef]

1925 (1)

W. Stenstrom and M. Reinhard, “Ultra-violet absorption spectra of blood serum and certain amino acids,” J. Biol. Chem.66, 819–827 (1925).

Anis, H.

Anjos, M. J.

C. G. L. Canellas, S. M. F. Carvalho, E. F. O. De Jesus, M. J. Anjos, and R. T. Lopes, “Trace and major elements in serum of patients with chronic myelogenous leukemia,” J. Radioanal. Nucl. Chem.269(3), 631–634 (2006).
[CrossRef]

Applegate, L. A.

F. Musumeci, L. A. Applegate, G. Privitera, A. Scordino, S. Tudisco, and H. J. Niggli, “Spectral analysis of laser-induced ultraweak delayed luminescence in cultured normal and tumor human cells: temperature dependence,” J. Photochem. Photobiol. B79(2), 93–99 (2005).
[CrossRef] [PubMed]

Aruna, P.

S. Madhuri, N. Vengadesan, P. Aruna, D. Koteeswaran, P. Venkatesan, and S. Ganesan, “Native fluorescence spectroscopy of blood plasma in the characterization of oral malignancy,” Photochem. Photobiol.78(2), 197–204 (2003).
[CrossRef] [PubMed]

Backhaus, J.

Bai, H.

H. Bai, P. Chen, L. Lin, S. J. Chang, G. Q. Tang, and G. G. Mu, “Physical mechanism of delayed luminescence from human serum,” Proc. SPIE7182, 71820K, 71820K-10 (2009).
[CrossRef]

Berger, A. J.

Brückmann, M.

Bugert, P.

Canellas, C. G. L.

C. G. L. Canellas, S. M. F. Carvalho, E. F. O. De Jesus, M. J. Anjos, and R. T. Lopes, “Trace and major elements in serum of patients with chronic myelogenous leukemia,” J. Radioanal. Nucl. Chem.269(3), 631–634 (2006).
[CrossRef]

Carvalho, S. M. F.

C. G. L. Canellas, S. M. F. Carvalho, E. F. O. De Jesus, M. J. Anjos, and R. T. Lopes, “Trace and major elements in serum of patients with chronic myelogenous leukemia,” J. Radioanal. Nucl. Chem.269(3), 631–634 (2006).
[CrossRef]

Chang, S. J.

H. Bai, P. Chen, L. Lin, S. J. Chang, G. Q. Tang, and G. G. Mu, “Physical mechanism of delayed luminescence from human serum,” Proc. SPIE7182, 71820K, 71820K-10 (2009).
[CrossRef]

Chen, G. N.

Chen, P.

H. Bai, P. Chen, L. Lin, S. J. Chang, G. Q. Tang, and G. G. Mu, “Physical mechanism of delayed luminescence from human serum,” Proc. SPIE7182, 71820K, 71820K-10 (2009).
[CrossRef]

Chen, Q.

C. L. Wang, D. Xing, L. Z. Zeng, C. F. Ding, and Q. Chen, “Effect of artificial acid rain and SO2 on characteristics of delayed light emission,” Luminescence20(1), 51–56 (2005).
[CrossRef] [PubMed]

Chen, R.

Chen, Y. P.

Cheun, B. S.

J. Kim, J. Lim, B. C. Lee, Y. U. Kim, S. K. Lee, B. S. Cheun, and K. S. Soh, “Spontaneous ultra-weak photon emission and delayed luminescence during carbon tetrachloride-induced liver injury and repair in mouse,” J. Health Sci.51(2), 155–160 (2005).
[CrossRef]

Choi, C. H.

H. W. Kim, S. B. Sim, C. K. Kim, J. Kim, C. H. Choi, H. R. You, and K. S. Soh, “Spontaneous photon emission and delayed luminescence of two types of human lung cancer tissues: adenocarcinoma and squamous cell carcinoma,” Cancer Lett.229(2), 283–289 (2005).
[CrossRef] [PubMed]

Chotia, A.

Y. Yan, F. A. Popp, S. Sigrist, D. Schlesinger, A. Dolf, Z. C. Yan, S. Cohen, and A. Chotia, “Further analysis of delayed luminescence of plants,” J. Photochem. Photobiol. B78(3), 235–244 (2005).
[CrossRef] [PubMed]

Cohen, S.

Y. Yan, F. A. Popp, S. Sigrist, D. Schlesinger, A. Dolf, Z. C. Yan, S. Cohen, and A. Chotia, “Further analysis of delayed luminescence of plants,” J. Photochem. Photobiol. B78(3), 235–244 (2005).
[CrossRef] [PubMed]

Costanzo, E.

E. Costanzo, M. Gulino, L. Lanzanò, F. Musumeci, A. Scordino, S. Tudisco, and L. Sui, “Single seed viability checked by delayed luminescence,” Eur. Biophys. J.37(2), 235–238 (2008).
[CrossRef] [PubMed]

De Jesus, E. F. O.

C. G. L. Canellas, S. M. F. Carvalho, E. F. O. De Jesus, M. J. Anjos, and R. T. Lopes, “Trace and major elements in serum of patients with chronic myelogenous leukemia,” J. Radioanal. Nucl. Chem.269(3), 631–634 (2006).
[CrossRef]

Ding, C. F.

C. L. Wang, D. Xing, L. Z. Zeng, C. F. Ding, and Q. Chen, “Effect of artificial acid rain and SO2 on characteristics of delayed light emission,” Luminescence20(1), 51–56 (2005).
[CrossRef] [PubMed]

Dolf, A.

Y. Yan, F. A. Popp, S. Sigrist, D. Schlesinger, A. Dolf, Z. C. Yan, S. Cohen, and A. Chotia, “Further analysis of delayed luminescence of plants,” J. Photochem. Photobiol. B78(3), 235–244 (2005).
[CrossRef] [PubMed]

Dzeyk-Boycheva, K.

Elmas, E.

Erdem, F.

F. Erdem, M. Gundogdu, and A. Kiziltunc, “Serum vascular endothelial growth factor level in patients with hematological malignancies,” Eur. J. Gen. Med.3, 116–120 (2006).

Feng, S. Y.

Fernandes, A.

Ganesan, S.

S. Madhuri, N. Vengadesan, P. Aruna, D. Koteeswaran, P. Venkatesan, and S. Ganesan, “Native fluorescence spectroscopy of blood plasma in the characterization of oral malignancy,” Photochem. Photobiol.78(2), 197–204 (2003).
[CrossRef] [PubMed]

Gulino, M.

E. Costanzo, M. Gulino, L. Lanzanò, F. Musumeci, A. Scordino, S. Tudisco, and L. Sui, “Single seed viability checked by delayed luminescence,” Eur. Biophys. J.37(2), 235–238 (2008).
[CrossRef] [PubMed]

Gundogdu, M.

F. Erdem, M. Gundogdu, and A. Kiziltunc, “Serum vascular endothelial growth factor level in patients with hematological malignancies,” Eur. J. Gen. Med.3, 116–120 (2006).

Haas, S. L.

Harb, A.

Hemberger, S.

Hohmann, J.

Khetani, A.

Kim, C. K.

H. W. Kim, S. B. Sim, C. K. Kim, J. Kim, C. H. Choi, H. R. You, and K. S. Soh, “Spontaneous photon emission and delayed luminescence of two types of human lung cancer tissues: adenocarcinoma and squamous cell carcinoma,” Cancer Lett.229(2), 283–289 (2005).
[CrossRef] [PubMed]

Kim, H. W.

H. W. Kim, S. B. Sim, C. K. Kim, J. Kim, C. H. Choi, H. R. You, and K. S. Soh, “Spontaneous photon emission and delayed luminescence of two types of human lung cancer tissues: adenocarcinoma and squamous cell carcinoma,” Cancer Lett.229(2), 283–289 (2005).
[CrossRef] [PubMed]

Kim, J.

H. W. Kim, S. B. Sim, C. K. Kim, J. Kim, C. H. Choi, H. R. You, and K. S. Soh, “Spontaneous photon emission and delayed luminescence of two types of human lung cancer tissues: adenocarcinoma and squamous cell carcinoma,” Cancer Lett.229(2), 283–289 (2005).
[CrossRef] [PubMed]

J. Kim, J. Lim, B. C. Lee, Y. U. Kim, S. K. Lee, B. S. Cheun, and K. S. Soh, “Spontaneous ultra-weak photon emission and delayed luminescence during carbon tetrachloride-induced liver injury and repair in mouse,” J. Health Sci.51(2), 155–160 (2005).
[CrossRef]

Kim, Y. U.

J. Kim, J. Lim, B. C. Lee, Y. U. Kim, S. K. Lee, B. S. Cheun, and K. S. Soh, “Spontaneous ultra-weak photon emission and delayed luminescence during carbon tetrachloride-induced liver injury and repair in mouse,” J. Health Sci.51(2), 155–160 (2005).
[CrossRef]

Kiziltunc, A.

F. Erdem, M. Gundogdu, and A. Kiziltunc, “Serum vascular endothelial growth factor level in patients with hematological malignancies,” Eur. J. Gen. Med.3, 116–120 (2006).

Koteeswaran, D.

S. Madhuri, N. Vengadesan, P. Aruna, D. Koteeswaran, P. Venkatesan, and S. Ganesan, “Native fluorescence spectroscopy of blood plasma in the characterization of oral malignancy,” Photochem. Photobiol.78(2), 197–204 (2003).
[CrossRef] [PubMed]

Lanzanò, L.

E. Costanzo, M. Gulino, L. Lanzanò, F. Musumeci, A. Scordino, S. Tudisco, and L. Sui, “Single seed viability checked by delayed luminescence,” Eur. Biophys. J.37(2), 235–238 (2008).
[CrossRef] [PubMed]

L. Lanzanò, A. Scordino, S. Privitera, S. Tudisco, and F. Musumeci, “Spectral analysis of Delayed Luminescence from human skin as a possible non-invasive diagnostic tool,” Eur. Biophys. J.36(7), 823–829 (2007).
[CrossRef] [PubMed]

Lee, B. C.

J. Kim, J. Lim, B. C. Lee, Y. U. Kim, S. K. Lee, B. S. Cheun, and K. S. Soh, “Spontaneous ultra-weak photon emission and delayed luminescence during carbon tetrachloride-induced liver injury and repair in mouse,” J. Health Sci.51(2), 155–160 (2005).
[CrossRef]

Lee, S. K.

J. Kim, J. Lim, B. C. Lee, Y. U. Kim, S. K. Lee, B. S. Cheun, and K. S. Soh, “Spontaneous ultra-weak photon emission and delayed luminescence during carbon tetrachloride-induced liver injury and repair in mouse,” J. Health Sci.51(2), 155–160 (2005).
[CrossRef]

Leiner, M.

O. S. Wolfbeis and M. Leiner, “Mapping of the total fluorescence of human blood serum as a new method for its characterization,” Anal. Chim. Acta167, 203–215 (1985).
[CrossRef]

Li, J. F.

X. D. Zhang, J. F. Li, Q. Q. Zhao, L. Zhang, and C. Pan, “The study on absorption spectrum of leukaemia's serum,” Laser & Infrared38, 267–269 (2008).

Lim, J.

J. Kim, J. Lim, B. C. Lee, Y. U. Kim, S. K. Lee, B. S. Cheun, and K. S. Soh, “Spontaneous ultra-weak photon emission and delayed luminescence during carbon tetrachloride-induced liver injury and repair in mouse,” J. Health Sci.51(2), 155–160 (2005).
[CrossRef]

Lin, D.

Lin, J. Q.

Lin, L.

H. Bai, P. Chen, L. Lin, S. J. Chang, G. Q. Tang, and G. G. Mu, “Physical mechanism of delayed luminescence from human serum,” Proc. SPIE7182, 71820K, 71820K-10 (2009).
[CrossRef]

Lopes, R. T.

C. G. L. Canellas, S. M. F. Carvalho, E. F. O. De Jesus, M. J. Anjos, and R. T. Lopes, “Trace and major elements in serum of patients with chronic myelogenous leukemia,” J. Radioanal. Nucl. Chem.269(3), 631–634 (2006).
[CrossRef]

Madhuri, S.

S. Madhuri, N. Vengadesan, P. Aruna, D. Koteeswaran, P. Venkatesan, and S. Ganesan, “Native fluorescence spectroscopy of blood plasma in the characterization of oral malignancy,” Photochem. Photobiol.78(2), 197–204 (2003).
[CrossRef] [PubMed]

Mu, G. G.

H. Bai, P. Chen, L. Lin, S. J. Chang, G. Q. Tang, and G. G. Mu, “Physical mechanism of delayed luminescence from human serum,” Proc. SPIE7182, 71820K, 71820K-10 (2009).
[CrossRef]

Müller, R.

Musumeci, F.

E. Costanzo, M. Gulino, L. Lanzanò, F. Musumeci, A. Scordino, S. Tudisco, and L. Sui, “Single seed viability checked by delayed luminescence,” Eur. Biophys. J.37(2), 235–238 (2008).
[CrossRef] [PubMed]

L. Lanzanò, A. Scordino, S. Privitera, S. Tudisco, and F. Musumeci, “Spectral analysis of Delayed Luminescence from human skin as a possible non-invasive diagnostic tool,” Eur. Biophys. J.36(7), 823–829 (2007).
[CrossRef] [PubMed]

F. Musumeci, L. A. Applegate, G. Privitera, A. Scordino, S. Tudisco, and H. J. Niggli, “Spectral analysis of laser-induced ultraweak delayed luminescence in cultured normal and tumor human cells: temperature dependence,” J. Photochem. Photobiol. B79(2), 93–99 (2005).
[CrossRef] [PubMed]

S. Tudisco, F. Musumeci, A. Scordino, and G. Privitera, “Advanced research equipment for fast ultraweak luminescence analysis,” Rev. Sci. Instrum.74(10), 4485–4490 (2003).
[CrossRef]

A. Scordino, A. Triglia, and F. Musumeci, “Analogous features of delayed luminescence from Acetabularia acetabulum and some solid state systems,” J. Photochem. Photobiol. B56(2-3), 181–186 (2000).
[CrossRef] [PubMed]

Niggli, H. J.

F. Musumeci, L. A. Applegate, G. Privitera, A. Scordino, S. Tudisco, and H. J. Niggli, “Spectral analysis of laser-induced ultraweak delayed luminescence in cultured normal and tumor human cells: temperature dependence,” J. Photochem. Photobiol. B79(2), 93–99 (2005).
[CrossRef] [PubMed]

Pan, C.

X. D. Zhang, J. F. Li, Q. Q. Zhao, L. Zhang, and C. Pan, “The study on absorption spectrum of leukaemia's serum,” Laser & Infrared38, 267–269 (2008).

Pan, J. J.

Patonay, G.

M. E. Rollie, G. Patonay, and I. M. Warner, “Automated sample deoxygenation for improved luminescence measurements,” Anal. Chem.59(1), 180–184 (1987).
[CrossRef]

Popp, F. A.

Y. Yan, F. A. Popp, S. Sigrist, D. Schlesinger, A. Dolf, Z. C. Yan, S. Cohen, and A. Chotia, “Further analysis of delayed luminescence of plants,” J. Photochem. Photobiol. B78(3), 235–244 (2005).
[CrossRef] [PubMed]

F. A. Popp and Y. Yan, “Delayed luminescence of biological systems in terms of coherent states,” Phys. Lett. A293(1-2), 93–97 (2002).
[CrossRef]

Privitera, G.

F. Musumeci, L. A. Applegate, G. Privitera, A. Scordino, S. Tudisco, and H. J. Niggli, “Spectral analysis of laser-induced ultraweak delayed luminescence in cultured normal and tumor human cells: temperature dependence,” J. Photochem. Photobiol. B79(2), 93–99 (2005).
[CrossRef] [PubMed]

S. Tudisco, F. Musumeci, A. Scordino, and G. Privitera, “Advanced research equipment for fast ultraweak luminescence analysis,” Rev. Sci. Instrum.74(10), 4485–4490 (2003).
[CrossRef]

Privitera, S.

L. Lanzanò, A. Scordino, S. Privitera, S. Tudisco, and F. Musumeci, “Spectral analysis of Delayed Luminescence from human skin as a possible non-invasive diagnostic tool,” Eur. Biophys. J.36(7), 823–829 (2007).
[CrossRef] [PubMed]

Qi, D. H.

Raichenok, T. F.

T. F. Raichenok, “Luminescence of human blood serum in the longwave spectral region,” J. Appl. Spectrosc.66(3), 470–472 (1999).
[CrossRef]

Reinhard, M.

W. Stenstrom and M. Reinhard, “Ultra-violet absorption spectra of blood serum and certain amino acids,” J. Biol. Chem.66, 819–827 (1925).

Rollie, M. E.

M. E. Rollie, G. Patonay, and I. M. Warner, “Automated sample deoxygenation for improved luminescence measurements,” Anal. Chem.59(1), 180–184 (1987).
[CrossRef]

Schlesinger, D.

Y. Yan, F. A. Popp, S. Sigrist, D. Schlesinger, A. Dolf, Z. C. Yan, S. Cohen, and A. Chotia, “Further analysis of delayed luminescence of plants,” J. Photochem. Photobiol. B78(3), 235–244 (2005).
[CrossRef] [PubMed]

Scordino, A.

E. Costanzo, M. Gulino, L. Lanzanò, F. Musumeci, A. Scordino, S. Tudisco, and L. Sui, “Single seed viability checked by delayed luminescence,” Eur. Biophys. J.37(2), 235–238 (2008).
[CrossRef] [PubMed]

L. Lanzanò, A. Scordino, S. Privitera, S. Tudisco, and F. Musumeci, “Spectral analysis of Delayed Luminescence from human skin as a possible non-invasive diagnostic tool,” Eur. Biophys. J.36(7), 823–829 (2007).
[CrossRef] [PubMed]

F. Musumeci, L. A. Applegate, G. Privitera, A. Scordino, S. Tudisco, and H. J. Niggli, “Spectral analysis of laser-induced ultraweak delayed luminescence in cultured normal and tumor human cells: temperature dependence,” J. Photochem. Photobiol. B79(2), 93–99 (2005).
[CrossRef] [PubMed]

S. Tudisco, F. Musumeci, A. Scordino, and G. Privitera, “Advanced research equipment for fast ultraweak luminescence analysis,” Rev. Sci. Instrum.74(10), 4485–4490 (2003).
[CrossRef]

A. Scordino, A. Triglia, and F. Musumeci, “Analogous features of delayed luminescence from Acetabularia acetabulum and some solid state systems,” J. Photochem. Photobiol. B56(2-3), 181–186 (2000).
[CrossRef] [PubMed]

Sigrist, S.

Y. Yan, F. A. Popp, S. Sigrist, D. Schlesinger, A. Dolf, Z. C. Yan, S. Cohen, and A. Chotia, “Further analysis of delayed luminescence of plants,” J. Photochem. Photobiol. B78(3), 235–244 (2005).
[CrossRef] [PubMed]

Sim, S. B.

H. W. Kim, S. B. Sim, C. K. Kim, J. Kim, C. H. Choi, H. R. You, and K. S. Soh, “Spontaneous photon emission and delayed luminescence of two types of human lung cancer tissues: adenocarcinoma and squamous cell carcinoma,” Cancer Lett.229(2), 283–289 (2005).
[CrossRef] [PubMed]

Soh, K. S.

H. W. Kim, S. B. Sim, C. K. Kim, J. Kim, C. H. Choi, H. R. You, and K. S. Soh, “Spontaneous photon emission and delayed luminescence of two types of human lung cancer tissues: adenocarcinoma and squamous cell carcinoma,” Cancer Lett.229(2), 283–289 (2005).
[CrossRef] [PubMed]

J. Kim, J. Lim, B. C. Lee, Y. U. Kim, S. K. Lee, B. S. Cheun, and K. S. Soh, “Spontaneous ultra-weak photon emission and delayed luminescence during carbon tetrachloride-induced liver injury and repair in mouse,” J. Health Sci.51(2), 155–160 (2005).
[CrossRef]

Stenstrom, W.

W. Stenstrom and M. Reinhard, “Ultra-violet absorption spectra of blood serum and certain amino acids,” J. Biol. Chem.66, 819–827 (1925).

Sui, L.

E. Costanzo, M. Gulino, L. Lanzanò, F. Musumeci, A. Scordino, S. Tudisco, and L. Sui, “Single seed viability checked by delayed luminescence,” Eur. Biophys. J.37(2), 235–238 (2008).
[CrossRef] [PubMed]

Tang, G. Q.

H. Bai, P. Chen, L. Lin, S. J. Chang, G. Q. Tang, and G. G. Mu, “Physical mechanism of delayed luminescence from human serum,” Proc. SPIE7182, 71820K, 71820K-10 (2009).
[CrossRef]

Tiwari, V. S.

Triglia, A.

A. Scordino, A. Triglia, and F. Musumeci, “Analogous features of delayed luminescence from Acetabularia acetabulum and some solid state systems,” J. Photochem. Photobiol. B56(2-3), 181–186 (2000).
[CrossRef] [PubMed]

Tudisco, S.

E. Costanzo, M. Gulino, L. Lanzanò, F. Musumeci, A. Scordino, S. Tudisco, and L. Sui, “Single seed viability checked by delayed luminescence,” Eur. Biophys. J.37(2), 235–238 (2008).
[CrossRef] [PubMed]

L. Lanzanò, A. Scordino, S. Privitera, S. Tudisco, and F. Musumeci, “Spectral analysis of Delayed Luminescence from human skin as a possible non-invasive diagnostic tool,” Eur. Biophys. J.36(7), 823–829 (2007).
[CrossRef] [PubMed]

F. Musumeci, L. A. Applegate, G. Privitera, A. Scordino, S. Tudisco, and H. J. Niggli, “Spectral analysis of laser-induced ultraweak delayed luminescence in cultured normal and tumor human cells: temperature dependence,” J. Photochem. Photobiol. B79(2), 93–99 (2005).
[CrossRef] [PubMed]

S. Tudisco, F. Musumeci, A. Scordino, and G. Privitera, “Advanced research equipment for fast ultraweak luminescence analysis,” Rev. Sci. Instrum.74(10), 4485–4490 (2003).
[CrossRef]

Vengadesan, N.

S. Madhuri, N. Vengadesan, P. Aruna, D. Koteeswaran, P. Venkatesan, and S. Ganesan, “Native fluorescence spectroscopy of blood plasma in the characterization of oral malignancy,” Photochem. Photobiol.78(2), 197–204 (2003).
[CrossRef] [PubMed]

Venkatesan, P.

S. Madhuri, N. Vengadesan, P. Aruna, D. Koteeswaran, P. Venkatesan, and S. Ganesan, “Native fluorescence spectroscopy of blood plasma in the characterization of oral malignancy,” Photochem. Photobiol.78(2), 197–204 (2003).
[CrossRef] [PubMed]

Wang, C. L.

C. L. Wang, D. Xing, L. Z. Zeng, C. F. Ding, and Q. Chen, “Effect of artificial acid rain and SO2 on characteristics of delayed light emission,” Luminescence20(1), 51–56 (2005).
[CrossRef] [PubMed]

Warner, I. M.

M. E. Rollie, G. Patonay, and I. M. Warner, “Automated sample deoxygenation for improved luminescence measurements,” Anal. Chem.59(1), 180–184 (1987).
[CrossRef]

Wolfbeis, O. S.

O. S. Wolfbeis and M. Leiner, “Mapping of the total fluorescence of human blood serum as a new method for its characterization,” Anal. Chim. Acta167, 203–215 (1985).
[CrossRef]

Würl, S.

Xie, S. S.

Xing, D.

C. L. Wang, D. Xing, L. Z. Zeng, C. F. Ding, and Q. Chen, “Effect of artificial acid rain and SO2 on characteristics of delayed light emission,” Luminescence20(1), 51–56 (2005).
[CrossRef] [PubMed]

Yan, Y.

Y. Yan, F. A. Popp, S. Sigrist, D. Schlesinger, A. Dolf, Z. C. Yan, S. Cohen, and A. Chotia, “Further analysis of delayed luminescence of plants,” J. Photochem. Photobiol. B78(3), 235–244 (2005).
[CrossRef] [PubMed]

F. A. Popp and Y. Yan, “Delayed luminescence of biological systems in terms of coherent states,” Phys. Lett. A293(1-2), 93–97 (2002).
[CrossRef]

Yan, Z. C.

Y. Yan, F. A. Popp, S. Sigrist, D. Schlesinger, A. Dolf, Z. C. Yan, S. Cohen, and A. Chotia, “Further analysis of delayed luminescence of plants,” J. Photochem. Photobiol. B78(3), 235–244 (2005).
[CrossRef] [PubMed]

You, H. R.

H. W. Kim, S. B. Sim, C. K. Kim, J. Kim, C. H. Choi, H. R. You, and K. S. Soh, “Spontaneous photon emission and delayed luminescence of two types of human lung cancer tissues: adenocarcinoma and squamous cell carcinoma,” Cancer Lett.229(2), 283–289 (2005).
[CrossRef] [PubMed]

Zeng, H. S.

Zeng, L. Z.

C. L. Wang, D. Xing, L. Z. Zeng, C. F. Ding, and Q. Chen, “Effect of artificial acid rain and SO2 on characteristics of delayed light emission,” Luminescence20(1), 51–56 (2005).
[CrossRef] [PubMed]

Zhang, L.

X. D. Zhang, J. F. Li, Q. Q. Zhao, L. Zhang, and C. Pan, “The study on absorption spectrum of leukaemia's serum,” Laser & Infrared38, 267–269 (2008).

Zhang, X. D.

X. D. Zhang, J. F. Li, Q. Q. Zhao, L. Zhang, and C. Pan, “The study on absorption spectrum of leukaemia's serum,” Laser & Infrared38, 267–269 (2008).

Zhao, Q. Q.

X. D. Zhang, J. F. Li, Q. Q. Zhao, L. Zhang, and C. Pan, “The study on absorption spectrum of leukaemia's serum,” Laser & Infrared38, 267–269 (2008).

Anal. Chem. (1)

M. E. Rollie, G. Patonay, and I. M. Warner, “Automated sample deoxygenation for improved luminescence measurements,” Anal. Chem.59(1), 180–184 (1987).
[CrossRef]

Anal. Chim. Acta (1)

O. S. Wolfbeis and M. Leiner, “Mapping of the total fluorescence of human blood serum as a new method for its characterization,” Anal. Chim. Acta167, 203–215 (1985).
[CrossRef]

Appl. Opt. (1)

Appl. Spectrosc. (1)

Cancer Lett. (1)

H. W. Kim, S. B. Sim, C. K. Kim, J. Kim, C. H. Choi, H. R. You, and K. S. Soh, “Spontaneous photon emission and delayed luminescence of two types of human lung cancer tissues: adenocarcinoma and squamous cell carcinoma,” Cancer Lett.229(2), 283–289 (2005).
[CrossRef] [PubMed]

Eur. Biophys. J. (2)

L. Lanzanò, A. Scordino, S. Privitera, S. Tudisco, and F. Musumeci, “Spectral analysis of Delayed Luminescence from human skin as a possible non-invasive diagnostic tool,” Eur. Biophys. J.36(7), 823–829 (2007).
[CrossRef] [PubMed]

E. Costanzo, M. Gulino, L. Lanzanò, F. Musumeci, A. Scordino, S. Tudisco, and L. Sui, “Single seed viability checked by delayed luminescence,” Eur. Biophys. J.37(2), 235–238 (2008).
[CrossRef] [PubMed]

Eur. J. Gen. Med. (1)

F. Erdem, M. Gundogdu, and A. Kiziltunc, “Serum vascular endothelial growth factor level in patients with hematological malignancies,” Eur. J. Gen. Med.3, 116–120 (2006).

J. Appl. Spectrosc. (1)

T. F. Raichenok, “Luminescence of human blood serum in the longwave spectral region,” J. Appl. Spectrosc.66(3), 470–472 (1999).
[CrossRef]

J. Biol. Chem. (1)

W. Stenstrom and M. Reinhard, “Ultra-violet absorption spectra of blood serum and certain amino acids,” J. Biol. Chem.66, 819–827 (1925).

J. Health Sci. (1)

J. Kim, J. Lim, B. C. Lee, Y. U. Kim, S. K. Lee, B. S. Cheun, and K. S. Soh, “Spontaneous ultra-weak photon emission and delayed luminescence during carbon tetrachloride-induced liver injury and repair in mouse,” J. Health Sci.51(2), 155–160 (2005).
[CrossRef]

J. Photochem. Photobiol. B (3)

Y. Yan, F. A. Popp, S. Sigrist, D. Schlesinger, A. Dolf, Z. C. Yan, S. Cohen, and A. Chotia, “Further analysis of delayed luminescence of plants,” J. Photochem. Photobiol. B78(3), 235–244 (2005).
[CrossRef] [PubMed]

F. Musumeci, L. A. Applegate, G. Privitera, A. Scordino, S. Tudisco, and H. J. Niggli, “Spectral analysis of laser-induced ultraweak delayed luminescence in cultured normal and tumor human cells: temperature dependence,” J. Photochem. Photobiol. B79(2), 93–99 (2005).
[CrossRef] [PubMed]

A. Scordino, A. Triglia, and F. Musumeci, “Analogous features of delayed luminescence from Acetabularia acetabulum and some solid state systems,” J. Photochem. Photobiol. B56(2-3), 181–186 (2000).
[CrossRef] [PubMed]

J. Radioanal. Nucl. Chem. (1)

C. G. L. Canellas, S. M. F. Carvalho, E. F. O. De Jesus, M. J. Anjos, and R. T. Lopes, “Trace and major elements in serum of patients with chronic myelogenous leukemia,” J. Radioanal. Nucl. Chem.269(3), 631–634 (2006).
[CrossRef]

Laser & Infrared (1)

X. D. Zhang, J. F. Li, Q. Q. Zhao, L. Zhang, and C. Pan, “The study on absorption spectrum of leukaemia's serum,” Laser & Infrared38, 267–269 (2008).

Luminescence (1)

C. L. Wang, D. Xing, L. Z. Zeng, C. F. Ding, and Q. Chen, “Effect of artificial acid rain and SO2 on characteristics of delayed light emission,” Luminescence20(1), 51–56 (2005).
[CrossRef] [PubMed]

Opt. Express (2)

Photochem. Photobiol. (1)

S. Madhuri, N. Vengadesan, P. Aruna, D. Koteeswaran, P. Venkatesan, and S. Ganesan, “Native fluorescence spectroscopy of blood plasma in the characterization of oral malignancy,” Photochem. Photobiol.78(2), 197–204 (2003).
[CrossRef] [PubMed]

Phys. Lett. A (1)

F. A. Popp and Y. Yan, “Delayed luminescence of biological systems in terms of coherent states,” Phys. Lett. A293(1-2), 93–97 (2002).
[CrossRef]

Proc. SPIE (1)

H. Bai, P. Chen, L. Lin, S. J. Chang, G. Q. Tang, and G. G. Mu, “Physical mechanism of delayed luminescence from human serum,” Proc. SPIE7182, 71820K, 71820K-10 (2009).
[CrossRef]

Rev. Sci. Instrum. (1)

S. Tudisco, F. Musumeci, A. Scordino, and G. Privitera, “Advanced research equipment for fast ultraweak luminescence analysis,” Rev. Sci. Instrum.74(10), 4485–4490 (2003).
[CrossRef]

Other (1)

The definition of p-value can be found at http://en.wikipedia.org/wiki/P-value .

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Figures (3)

Fig. 1
Fig. 1

(a) Absorption spectra of human serum. (b) DL spectra of human serum. (c) DL intensities of human serum in the sample chamber filled with oxygen, air, and nitrogen.

Fig. 2
Fig. 2

DL decay curves of normal (red) and leukemic (black) human sera. Each curve represents the mean values of three individual measurements. The data are fitted using hyperbolic function Eq. (1) (green). For normal serum, I0 = 5347 c/1.31 ms, t0 = 111.92 ms, m = 1.276, R2 = 0.997. For leukemic serum, I0 = 26325 c/1.31 ms, t0 = 315.04 ms, m = 1.574, R2 = 0.999. The background (blue) was obtained by replacing the serum sample with magnesia powder.

Fig. 3
Fig. 3

(a) Weight distribution of the decay rate v for the DL of normal and leukemic serum samples. (b) Comparison of I0, vmax, and Fmax between normal and leukemic human sera.

Equations (5)

Equations on this page are rendered with MathJax. Learn more.

I(t)= I 0 ( 1+t/ t 0 ) m ,
I(t)= 0 Af(v) e vt dv ,
f(v)= t 0 m v m1 e v t 0 /Γ(m),
v max = m1 t 0 ,
F max =f( v max )= t 0 (m1) m1 e 1m /Γ(m).

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