Abstract

The hybrid nature of optoacoustic imaging might impose limitations on concurrent placement of optical and ultrasonic detection components, especially in high resolution microscopic applications that require dense arrangements and miniaturization of components. This hinders optimal deployment of the optical excitation and ultrasonic detection paths, leading to reduction of imaging speed and spatial resolution performance. We suggest a compact coaxial design for optoacoustic microscopy that allows optimizing both the light illumination and ultrasonic detection parameters of the imaging system. System performance is showcased in phantoms and in vivo imaging of microvasculature, achieving real time operation in two dimensions and penetration of 6 mm into optically dense human tissues.

© 2012 OSA

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  1. D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multi-spectral optoacoustic tomography of deep-seated fluorescent proteins in-vivo,” Nat. Photonics3(7), 412–417 (2009).
    [CrossRef]
  2. D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc.6(8), 1121–1129 (2011).
    [CrossRef] [PubMed]
  3. J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
    [CrossRef] [PubMed]
  4. L. Song, K. Maslov, K. K. Shung, and L. V. Wang, “Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo,” J. Biomed. Opt.15(2), 021303 (2010).
    [CrossRef] [PubMed]
  5. R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, “Realtime photoacoustic microscopy of murine cardiovascular dynamics,” Opt. Express16(22), 18551–18556 (2008).
    [CrossRef] [PubMed]
  6. H. F. Zhang, K. Maslov, and L. V. Wang, “In vivo imaging of subcutaneous structures using functional photoacoustic microscopy,” Nat. Protoc.2(4), 797–804 (2007).
    [CrossRef] [PubMed]
  7. Z. Xie, S.-L. Chen, T. Ling, L. J. Guo, P. L. Carson, and X. Wang, “Pure optical photoacoustic microscopy,” Opt. Express19(10), 9027–9034 (2011).
    [CrossRef] [PubMed]
  8. E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol.54(4), 1035–1046 (2009).
    [CrossRef] [PubMed]
  9. L. Wang, K. Maslov, J. Yao, B. Rao, and L. V. Wang, “Fast voice-coil scanning optical-resolution photoacoustic microscopy,” Opt. Lett.36(2), 139–141 (2011).
    [CrossRef] [PubMed]
  10. Z. Xie, S. Jiao, H. F. Zhang, and C. A. Puliafito, “Laser-scanning optical-resolution photoacoustic microscopy,” Opt. Lett.34(12), 1771–1773 (2009).
    [CrossRef] [PubMed]
  11. C. Zhang, K. Maslov, S. Hu, R. Chen, Q. Zhou, K. K. Shung, and L. V. Wang, “Reflection-mode submicron-resolution in vivo photoacoustic microscopy,” J. Biomed. Opt.17(2), 020501 (2012).
    [CrossRef] [PubMed]
  12. M. L. Li, H. E. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Improved in vivo photoacoustic microscopy based on a virtual-detector concept,” Opt. Lett.31(4), 474–476 (2006).
    [CrossRef] [PubMed]
  13. C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011).
    [CrossRef] [PubMed]
  14. E. W. Stein, K. Maslov, and L. V. Wang, “Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy,” J. Biomed. Opt.14(2), 020502 (2009).
    [CrossRef] [PubMed]
  15. M. Cutolo, A. Sulli, M. E. Secchi, S. Paolino, and C. Pizzorni, “Nailfold capillaroscopy is useful for the diagnosis and follow-up of autoimmune rheumatic diseases. a future tool for the analysis of microvascular heart involvement?” Rheumatol.45(Supplement 4), 43–46 (2006).
    [CrossRef]
  16. P.-C. Wu, M.-N. Huang, S.-C. Hsieh, and C.-L. Yu, “Diagnostic value of nailfold capillaroscopy to systemic sclerosis with Raynaud's phenomenon: a preliminary study,” Formosan J. Rheumatol.23, 37–42 (2009).

2012 (1)

C. Zhang, K. Maslov, S. Hu, R. Chen, Q. Zhou, K. K. Shung, and L. V. Wang, “Reflection-mode submicron-resolution in vivo photoacoustic microscopy,” J. Biomed. Opt.17(2), 020501 (2012).
[CrossRef] [PubMed]

2011 (4)

L. Wang, K. Maslov, J. Yao, B. Rao, and L. V. Wang, “Fast voice-coil scanning optical-resolution photoacoustic microscopy,” Opt. Lett.36(2), 139–141 (2011).
[CrossRef] [PubMed]

Z. Xie, S.-L. Chen, T. Ling, L. J. Guo, P. L. Carson, and X. Wang, “Pure optical photoacoustic microscopy,” Opt. Express19(10), 9027–9034 (2011).
[CrossRef] [PubMed]

D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc.6(8), 1121–1129 (2011).
[CrossRef] [PubMed]

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011).
[CrossRef] [PubMed]

2010 (1)

L. Song, K. Maslov, K. K. Shung, and L. V. Wang, “Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo,” J. Biomed. Opt.15(2), 021303 (2010).
[CrossRef] [PubMed]

2009 (5)

E. W. Stein, K. Maslov, and L. V. Wang, “Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy,” J. Biomed. Opt.14(2), 020502 (2009).
[CrossRef] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multi-spectral optoacoustic tomography of deep-seated fluorescent proteins in-vivo,” Nat. Photonics3(7), 412–417 (2009).
[CrossRef]

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol.54(4), 1035–1046 (2009).
[CrossRef] [PubMed]

Z. Xie, S. Jiao, H. F. Zhang, and C. A. Puliafito, “Laser-scanning optical-resolution photoacoustic microscopy,” Opt. Lett.34(12), 1771–1773 (2009).
[CrossRef] [PubMed]

P.-C. Wu, M.-N. Huang, S.-C. Hsieh, and C.-L. Yu, “Diagnostic value of nailfold capillaroscopy to systemic sclerosis with Raynaud's phenomenon: a preliminary study,” Formosan J. Rheumatol.23, 37–42 (2009).

2008 (2)

R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, “Realtime photoacoustic microscopy of murine cardiovascular dynamics,” Opt. Express16(22), 18551–18556 (2008).
[CrossRef] [PubMed]

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

2007 (1)

H. F. Zhang, K. Maslov, and L. V. Wang, “In vivo imaging of subcutaneous structures using functional photoacoustic microscopy,” Nat. Protoc.2(4), 797–804 (2007).
[CrossRef] [PubMed]

2006 (2)

M. Cutolo, A. Sulli, M. E. Secchi, S. Paolino, and C. Pizzorni, “Nailfold capillaroscopy is useful for the diagnosis and follow-up of autoimmune rheumatic diseases. a future tool for the analysis of microvascular heart involvement?” Rheumatol.45(Supplement 4), 43–46 (2006).
[CrossRef]

M. L. Li, H. E. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Improved in vivo photoacoustic microscopy based on a virtual-detector concept,” Opt. Lett.31(4), 474–476 (2006).
[CrossRef] [PubMed]

Aguirre, A.

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

Beard, P. C.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol.54(4), 1035–1046 (2009).
[CrossRef] [PubMed]

Bitton, R.

Buehler, A.

D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc.6(8), 1121–1129 (2011).
[CrossRef] [PubMed]

Carson, P. L.

Castillo, D.

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

Chen, R.

C. Zhang, K. Maslov, S. Hu, R. Chen, Q. Zhou, K. K. Shung, and L. V. Wang, “Reflection-mode submicron-resolution in vivo photoacoustic microscopy,” J. Biomed. Opt.17(2), 020501 (2012).
[CrossRef] [PubMed]

Chen, S.-L.

Cornelius, L. A.

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011).
[CrossRef] [PubMed]

Cutolo, M.

M. Cutolo, A. Sulli, M. E. Secchi, S. Paolino, and C. Pizzorni, “Nailfold capillaroscopy is useful for the diagnosis and follow-up of autoimmune rheumatic diseases. a future tool for the analysis of microvascular heart involvement?” Rheumatol.45(Supplement 4), 43–46 (2006).
[CrossRef]

Distel, M.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multi-spectral optoacoustic tomography of deep-seated fluorescent proteins in-vivo,” Nat. Photonics3(7), 412–417 (2009).
[CrossRef]

Favazza, C. P.

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011).
[CrossRef] [PubMed]

Gamelin, J.

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

Guo, L. J.

Hsieh, S.-C.

P.-C. Wu, M.-N. Huang, S.-C. Hsieh, and C.-L. Yu, “Diagnostic value of nailfold capillaroscopy to systemic sclerosis with Raynaud's phenomenon: a preliminary study,” Formosan J. Rheumatol.23, 37–42 (2009).

Hu, S.

C. Zhang, K. Maslov, S. Hu, R. Chen, Q. Zhou, K. K. Shung, and L. V. Wang, “Reflection-mode submicron-resolution in vivo photoacoustic microscopy,” J. Biomed. Opt.17(2), 020501 (2012).
[CrossRef] [PubMed]

Huang, F.

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

Huang, M.-N.

P.-C. Wu, M.-N. Huang, S.-C. Hsieh, and C.-L. Yu, “Diagnostic value of nailfold capillaroscopy to systemic sclerosis with Raynaud's phenomenon: a preliminary study,” Formosan J. Rheumatol.23, 37–42 (2009).

Jiao, S.

Köster, R. W.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multi-spectral optoacoustic tomography of deep-seated fluorescent proteins in-vivo,” Nat. Photonics3(7), 412–417 (2009).
[CrossRef]

Laufer, J. G.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol.54(4), 1035–1046 (2009).
[CrossRef] [PubMed]

Li, M. L.

Ling, T.

Ma, R.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multi-spectral optoacoustic tomography of deep-seated fluorescent proteins in-vivo,” Nat. Photonics3(7), 412–417 (2009).
[CrossRef]

Maslov, K.

C. Zhang, K. Maslov, S. Hu, R. Chen, Q. Zhou, K. K. Shung, and L. V. Wang, “Reflection-mode submicron-resolution in vivo photoacoustic microscopy,” J. Biomed. Opt.17(2), 020501 (2012).
[CrossRef] [PubMed]

L. Wang, K. Maslov, J. Yao, B. Rao, and L. V. Wang, “Fast voice-coil scanning optical-resolution photoacoustic microscopy,” Opt. Lett.36(2), 139–141 (2011).
[CrossRef] [PubMed]

L. Song, K. Maslov, K. K. Shung, and L. V. Wang, “Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo,” J. Biomed. Opt.15(2), 021303 (2010).
[CrossRef] [PubMed]

E. W. Stein, K. Maslov, and L. V. Wang, “Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy,” J. Biomed. Opt.14(2), 020502 (2009).
[CrossRef] [PubMed]

H. F. Zhang, K. Maslov, and L. V. Wang, “In vivo imaging of subcutaneous structures using functional photoacoustic microscopy,” Nat. Protoc.2(4), 797–804 (2007).
[CrossRef] [PubMed]

M. L. Li, H. E. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Improved in vivo photoacoustic microscopy based on a virtual-detector concept,” Opt. Lett.31(4), 474–476 (2006).
[CrossRef] [PubMed]

Maurudis, A.

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

Ntziachristos, V.

D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc.6(8), 1121–1129 (2011).
[CrossRef] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multi-spectral optoacoustic tomography of deep-seated fluorescent proteins in-vivo,” Nat. Photonics3(7), 412–417 (2009).
[CrossRef]

Paolino, S.

M. Cutolo, A. Sulli, M. E. Secchi, S. Paolino, and C. Pizzorni, “Nailfold capillaroscopy is useful for the diagnosis and follow-up of autoimmune rheumatic diseases. a future tool for the analysis of microvascular heart involvement?” Rheumatol.45(Supplement 4), 43–46 (2006).
[CrossRef]

Pedley, R. B.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol.54(4), 1035–1046 (2009).
[CrossRef] [PubMed]

Perrimon, N.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multi-spectral optoacoustic tomography of deep-seated fluorescent proteins in-vivo,” Nat. Photonics3(7), 412–417 (2009).
[CrossRef]

Pizzorni, C.

M. Cutolo, A. Sulli, M. E. Secchi, S. Paolino, and C. Pizzorni, “Nailfold capillaroscopy is useful for the diagnosis and follow-up of autoimmune rheumatic diseases. a future tool for the analysis of microvascular heart involvement?” Rheumatol.45(Supplement 4), 43–46 (2006).
[CrossRef]

Puliafito, C. A.

Rao, B.

Razansky, D.

D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc.6(8), 1121–1129 (2011).
[CrossRef] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multi-spectral optoacoustic tomography of deep-seated fluorescent proteins in-vivo,” Nat. Photonics3(7), 412–417 (2009).
[CrossRef]

Secchi, M. E.

M. Cutolo, A. Sulli, M. E. Secchi, S. Paolino, and C. Pizzorni, “Nailfold capillaroscopy is useful for the diagnosis and follow-up of autoimmune rheumatic diseases. a future tool for the analysis of microvascular heart involvement?” Rheumatol.45(Supplement 4), 43–46 (2006).
[CrossRef]

Shung, K. K.

C. Zhang, K. Maslov, S. Hu, R. Chen, Q. Zhou, K. K. Shung, and L. V. Wang, “Reflection-mode submicron-resolution in vivo photoacoustic microscopy,” J. Biomed. Opt.17(2), 020501 (2012).
[CrossRef] [PubMed]

L. Song, K. Maslov, K. K. Shung, and L. V. Wang, “Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo,” J. Biomed. Opt.15(2), 021303 (2010).
[CrossRef] [PubMed]

R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, “Realtime photoacoustic microscopy of murine cardiovascular dynamics,” Opt. Express16(22), 18551–18556 (2008).
[CrossRef] [PubMed]

Song, L.

L. Song, K. Maslov, K. K. Shung, and L. V. Wang, “Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo,” J. Biomed. Opt.15(2), 021303 (2010).
[CrossRef] [PubMed]

R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, “Realtime photoacoustic microscopy of murine cardiovascular dynamics,” Opt. Express16(22), 18551–18556 (2008).
[CrossRef] [PubMed]

Stein, E. W.

E. W. Stein, K. Maslov, and L. V. Wang, “Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy,” J. Biomed. Opt.14(2), 020502 (2009).
[CrossRef] [PubMed]

Stoica, G.

Sulli, A.

M. Cutolo, A. Sulli, M. E. Secchi, S. Paolino, and C. Pizzorni, “Nailfold capillaroscopy is useful for the diagnosis and follow-up of autoimmune rheumatic diseases. a future tool for the analysis of microvascular heart involvement?” Rheumatol.45(Supplement 4), 43–46 (2006).
[CrossRef]

Vinegoni, C.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multi-spectral optoacoustic tomography of deep-seated fluorescent proteins in-vivo,” Nat. Photonics3(7), 412–417 (2009).
[CrossRef]

Wang, L.

Wang, L. V.

C. Zhang, K. Maslov, S. Hu, R. Chen, Q. Zhou, K. K. Shung, and L. V. Wang, “Reflection-mode submicron-resolution in vivo photoacoustic microscopy,” J. Biomed. Opt.17(2), 020501 (2012).
[CrossRef] [PubMed]

L. Wang, K. Maslov, J. Yao, B. Rao, and L. V. Wang, “Fast voice-coil scanning optical-resolution photoacoustic microscopy,” Opt. Lett.36(2), 139–141 (2011).
[CrossRef] [PubMed]

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011).
[CrossRef] [PubMed]

L. Song, K. Maslov, K. K. Shung, and L. V. Wang, “Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo,” J. Biomed. Opt.15(2), 021303 (2010).
[CrossRef] [PubMed]

E. W. Stein, K. Maslov, and L. V. Wang, “Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy,” J. Biomed. Opt.14(2), 020502 (2009).
[CrossRef] [PubMed]

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, “Realtime photoacoustic microscopy of murine cardiovascular dynamics,” Opt. Express16(22), 18551–18556 (2008).
[CrossRef] [PubMed]

H. F. Zhang, K. Maslov, and L. V. Wang, “In vivo imaging of subcutaneous structures using functional photoacoustic microscopy,” Nat. Protoc.2(4), 797–804 (2007).
[CrossRef] [PubMed]

M. L. Li, H. E. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Improved in vivo photoacoustic microscopy based on a virtual-detector concept,” Opt. Lett.31(4), 474–476 (2006).
[CrossRef] [PubMed]

Wang, X.

Wu, P.-C.

P.-C. Wu, M.-N. Huang, S.-C. Hsieh, and C.-L. Yu, “Diagnostic value of nailfold capillaroscopy to systemic sclerosis with Raynaud's phenomenon: a preliminary study,” Formosan J. Rheumatol.23, 37–42 (2009).

Xie, Z.

Yao, J.

Yu, C.-L.

P.-C. Wu, M.-N. Huang, S.-C. Hsieh, and C.-L. Yu, “Diagnostic value of nailfold capillaroscopy to systemic sclerosis with Raynaud's phenomenon: a preliminary study,” Formosan J. Rheumatol.23, 37–42 (2009).

Zemp, R. J.

Zhang, C.

C. Zhang, K. Maslov, S. Hu, R. Chen, Q. Zhou, K. K. Shung, and L. V. Wang, “Reflection-mode submicron-resolution in vivo photoacoustic microscopy,” J. Biomed. Opt.17(2), 020501 (2012).
[CrossRef] [PubMed]

Zhang, E. Z.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol.54(4), 1035–1046 (2009).
[CrossRef] [PubMed]

Zhang, H. E.

Zhang, H. F.

Z. Xie, S. Jiao, H. F. Zhang, and C. A. Puliafito, “Laser-scanning optical-resolution photoacoustic microscopy,” Opt. Lett.34(12), 1771–1773 (2009).
[CrossRef] [PubMed]

H. F. Zhang, K. Maslov, and L. V. Wang, “In vivo imaging of subcutaneous structures using functional photoacoustic microscopy,” Nat. Protoc.2(4), 797–804 (2007).
[CrossRef] [PubMed]

Zhou, Q.

C. Zhang, K. Maslov, S. Hu, R. Chen, Q. Zhou, K. K. Shung, and L. V. Wang, “Reflection-mode submicron-resolution in vivo photoacoustic microscopy,” J. Biomed. Opt.17(2), 020501 (2012).
[CrossRef] [PubMed]

Zhu, Q.

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

Formosan J. Rheumatol. (1)

P.-C. Wu, M.-N. Huang, S.-C. Hsieh, and C.-L. Yu, “Diagnostic value of nailfold capillaroscopy to systemic sclerosis with Raynaud's phenomenon: a preliminary study,” Formosan J. Rheumatol.23, 37–42 (2009).

J. Biomed. Opt. (5)

C. Zhang, K. Maslov, S. Hu, R. Chen, Q. Zhou, K. K. Shung, and L. V. Wang, “Reflection-mode submicron-resolution in vivo photoacoustic microscopy,” J. Biomed. Opt.17(2), 020501 (2012).
[CrossRef] [PubMed]

J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt.13(2), 024007 (2008).
[CrossRef] [PubMed]

L. Song, K. Maslov, K. K. Shung, and L. V. Wang, “Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo,” J. Biomed. Opt.15(2), 021303 (2010).
[CrossRef] [PubMed]

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011).
[CrossRef] [PubMed]

E. W. Stein, K. Maslov, and L. V. Wang, “Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy,” J. Biomed. Opt.14(2), 020502 (2009).
[CrossRef] [PubMed]

Nat. Photonics (1)

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multi-spectral optoacoustic tomography of deep-seated fluorescent proteins in-vivo,” Nat. Photonics3(7), 412–417 (2009).
[CrossRef]

Nat. Protoc. (2)

D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc.6(8), 1121–1129 (2011).
[CrossRef] [PubMed]

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Opt. Express (2)

Opt. Lett. (3)

Phys. Med. Biol. (1)

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Rheumatol. (1)

M. Cutolo, A. Sulli, M. E. Secchi, S. Paolino, and C. Pizzorni, “Nailfold capillaroscopy is useful for the diagnosis and follow-up of autoimmune rheumatic diseases. a future tool for the analysis of microvascular heart involvement?” Rheumatol.45(Supplement 4), 43–46 (2006).
[CrossRef]

Supplementary Material (2)

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