Abstract

Tissue simulating phantoms are an important part of instrumentation validation, standardization/training and clinical translation. Properly used, phantoms form the backbone of sound quality control procedures. We describe the development and testing of a series of optically turbid phantoms used in a multi-center American College of Radiology Imaging Network (ACRIN) clinical trial of Diffuse Optical Spectroscopic Imaging (DOSI). The ACRIN trial is designed to measure the response of breast tumors to neoadjuvant chemotherapy. Phantom measurements are used to determine absolute instrument response functions during each measurement session and assess both long and short-term operator and instrument reliability.

© 2012 OSA

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2011 (1)

A. E. Cerussi, V. W. Tanamai, D. Hsiang, J. Butler, R. S. Mehta, B. J. Tromberg, “Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy,” Philos. Transact. A Math. Phys. Eng. Sci. 369(1955), 4512–4530 (2011).
[CrossRef] [PubMed]

2008 (1)

S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang, B. J. Tromberg, “In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy,” Phys. Med. Biol. 53(23), 6713–6727 (2008).
[CrossRef] [PubMed]

2007 (1)

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, R. Richards-Kortum, “Design of a multispectral digital colposcope,” Proc. SPIE 6430, 64301S, 64301S-8 (2007).
[CrossRef]

2006 (3)

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

B. W. Pogue, M. S. Patterson, “Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry,” J. Biomed. Opt. 11(4), 041102 (2006).
[CrossRef] [PubMed]

A. M. De Grand, S. J. Lomnes, D. S. Lee, M. Pietrzykowski, S. Ohnishi, T. G. Morgan, A. Gogbashian, R. G. Laurence, J. V. Frangioni, “Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons,” J. Biomed. Opt. 11(1), 014007 (2006).
[CrossRef] [PubMed]

2005 (2)

2003 (1)

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

1997 (2)

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, G. Valentini, “A solid tissue phantom for photon migration studies,” Phys. Med. Biol. 42(10), 1971–1979 (1997).
[CrossRef] [PubMed]

G. Wagnières, S. Cheng, M. Zellweger, N. Utke, D. Braichotte, J.-P. Ballini, H. van den Bergh, “An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy,” Phys. Med. Biol. 42(7), 1415–1426 (1997).
[CrossRef] [PubMed]

1996 (1)

J. B. Fishkin, S. Fantini, M. J. vandeVen, E. Gratton, “Gigahertz photon density waves in a turbid medium: Theory and experiments,” Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics 53(3), 2307–2319 (1996).
[CrossRef] [PubMed]

1991 (1)

Andersson-Engels, S.

Au, S.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, R. Richards-Kortum, “Design of a multispectral digital colposcope,” Proc. SPIE 6430, 64301S, 64301S-8 (2007).
[CrossRef]

Avrillier, S.

Baek, H. M.

S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang, B. J. Tromberg, “In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy,” Phys. Med. Biol. 53(23), 6713–6727 (2008).
[CrossRef] [PubMed]

Ballini, J.-P.

G. Wagnières, S. Cheng, M. Zellweger, N. Utke, D. Braichotte, J.-P. Ballini, H. van den Bergh, “An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy,” Phys. Med. Biol. 42(7), 1415–1426 (1997).
[CrossRef] [PubMed]

Bassi, A.

Birgul, O.

S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang, B. J. Tromberg, “In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy,” Phys. Med. Biol. 53(23), 6713–6727 (2008).
[CrossRef] [PubMed]

Braichotte, D.

G. Wagnières, S. Cheng, M. Zellweger, N. Utke, D. Braichotte, J.-P. Ballini, H. van den Bergh, “An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy,” Phys. Med. Biol. 42(7), 1415–1426 (1997).
[CrossRef] [PubMed]

Brooksby, B.

Butler, J.

A. E. Cerussi, V. W. Tanamai, D. Hsiang, J. Butler, R. S. Mehta, B. J. Tromberg, “Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy,” Philos. Transact. A Math. Phys. Eng. Sci. 369(1955), 4512–4530 (2011).
[CrossRef] [PubMed]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

Cardeno, M.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, R. Richards-Kortum, “Design of a multispectral digital colposcope,” Proc. SPIE 6430, 64301S, 64301S-8 (2007).
[CrossRef]

Cerussi, A.

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

Cerussi, A. E.

A. E. Cerussi, V. W. Tanamai, D. Hsiang, J. Butler, R. S. Mehta, B. J. Tromberg, “Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy,” Philos. Transact. A Math. Phys. Eng. Sci. 369(1955), 4512–4530 (2011).
[CrossRef] [PubMed]

S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang, B. J. Tromberg, “In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy,” Phys. Med. Biol. 53(23), 6713–6727 (2008).
[CrossRef] [PubMed]

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Cheng, S.

G. Wagnières, S. Cheng, M. Zellweger, N. Utke, D. Braichotte, J.-P. Ballini, H. van den Bergh, “An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy,” Phys. Med. Biol. 42(7), 1415–1426 (1997).
[CrossRef] [PubMed]

Chiou, G.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Chu, Y.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Chung, S. H.

S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang, B. J. Tromberg, “In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy,” Phys. Med. Biol. 53(23), 6713–6727 (2008).
[CrossRef] [PubMed]

Cubeddu, R.

De Grand, A. M.

A. M. De Grand, S. J. Lomnes, D. S. Lee, M. Pietrzykowski, S. Ohnishi, T. G. Morgan, A. Gogbashian, R. G. Laurence, J. V. Frangioni, “Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons,” J. Biomed. Opt. 11(1), 014007 (2006).
[CrossRef] [PubMed]

Dehghani, H.

Deng, C.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Durkin, A.

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

Durkin, A. J.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Fantini, S.

J. B. Fishkin, S. Fantini, M. J. vandeVen, E. Gratton, “Gigahertz photon density waves in a turbid medium: Theory and experiments,” Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics 53(3), 2307–2319 (1996).
[CrossRef] [PubMed]

Fishkin, J. B.

J. B. Fishkin, S. Fantini, M. J. vandeVen, E. Gratton, “Gigahertz photon density waves in a turbid medium: Theory and experiments,” Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics 53(3), 2307–2319 (1996).
[CrossRef] [PubMed]

Follen, M.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, R. Richards-Kortum, “Design of a multispectral digital colposcope,” Proc. SPIE 6430, 64301S, 64301S-8 (2007).
[CrossRef]

Frangioni, J. V.

A. M. De Grand, S. J. Lomnes, D. S. Lee, M. Pietrzykowski, S. Ohnishi, T. G. Morgan, A. Gogbashian, R. G. Laurence, J. V. Frangioni, “Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons,” J. Biomed. Opt. 11(1), 014007 (2006).
[CrossRef] [PubMed]

Gogbashian, A.

A. M. De Grand, S. J. Lomnes, D. S. Lee, M. Pietrzykowski, S. Ohnishi, T. G. Morgan, A. Gogbashian, R. G. Laurence, J. V. Frangioni, “Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons,” J. Biomed. Opt. 11(1), 014007 (2006).
[CrossRef] [PubMed]

Gratton, E.

J. B. Fishkin, S. Fantini, M. J. vandeVen, E. Gratton, “Gigahertz photon density waves in a turbid medium: Theory and experiments,” Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics 53(3), 2307–2319 (1996).
[CrossRef] [PubMed]

Grosenick, D.

Gulsen, G.

S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang, B. J. Tromberg, “In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy,” Phys. Med. Biol. 53(23), 6713–6727 (2008).
[CrossRef] [PubMed]

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Hsiang, D.

A. E. Cerussi, V. W. Tanamai, D. Hsiang, J. Butler, R. S. Mehta, B. J. Tromberg, “Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy,” Philos. Transact. A Math. Phys. Eng. Sci. 369(1955), 4512–4530 (2011).
[CrossRef] [PubMed]

S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang, B. J. Tromberg, “In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy,” Phys. Med. Biol. 53(23), 6713–6727 (2008).
[CrossRef] [PubMed]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

Jiang, S.

Klifa, C.

S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang, B. J. Tromberg, “In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy,” Phys. Med. Biol. 53(23), 6713–6727 (2008).
[CrossRef] [PubMed]

Kogel, C.

Laurence, R. G.

A. M. De Grand, S. J. Lomnes, D. S. Lee, M. Pietrzykowski, S. Ohnishi, T. G. Morgan, A. Gogbashian, R. G. Laurence, J. V. Frangioni, “Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons,” J. Biomed. Opt. 11(1), 014007 (2006).
[CrossRef] [PubMed]

Lee, D. S.

A. M. De Grand, S. J. Lomnes, D. S. Lee, M. Pietrzykowski, S. Ohnishi, T. G. Morgan, A. Gogbashian, R. G. Laurence, J. V. Frangioni, “Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons,” J. Biomed. Opt. 11(1), 014007 (2006).
[CrossRef] [PubMed]

Lomnes, S. J.

A. M. De Grand, S. J. Lomnes, D. S. Lee, M. Pietrzykowski, S. Ohnishi, T. G. Morgan, A. Gogbashian, R. G. Laurence, J. V. Frangioni, “Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons,” J. Biomed. Opt. 11(1), 014007 (2006).
[CrossRef] [PubMed]

MacAulay, C. E.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, R. Richards-Kortum, “Design of a multispectral digital colposcope,” Proc. SPIE 6430, 64301S, 64301S-8 (2007).
[CrossRef]

Macdonald, R.

MacKinnon, N. B.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, R. Richards-Kortum, “Design of a multispectral digital colposcope,” Proc. SPIE 6430, 64301S, 64301S-8 (2007).
[CrossRef]

Mehta, R. S.

A. E. Cerussi, V. W. Tanamai, D. Hsiang, J. Butler, R. S. Mehta, B. J. Tromberg, “Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy,” Philos. Transact. A Math. Phys. Eng. Sci. 369(1955), 4512–4530 (2011).
[CrossRef] [PubMed]

Merritt, S.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Merritt, S. I.

S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang, B. J. Tromberg, “In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy,” Phys. Med. Biol. 53(23), 6713–6727 (2008).
[CrossRef] [PubMed]

Moes, C. J.

Möller, M.

Morgan, T. G.

A. M. De Grand, S. J. Lomnes, D. S. Lee, M. Pietrzykowski, S. Ohnishi, T. G. Morgan, A. Gogbashian, R. G. Laurence, J. V. Frangioni, “Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons,” J. Biomed. Opt. 11(1), 014007 (2006).
[CrossRef] [PubMed]

Nalcioglu, O.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Nghiem, H. L.

Ohnishi, S.

A. M. De Grand, S. J. Lomnes, D. S. Lee, M. Pietrzykowski, S. Ohnishi, T. G. Morgan, A. Gogbashian, R. G. Laurence, J. V. Frangioni, “Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons,” J. Biomed. Opt. 11(1), 014007 (2006).
[CrossRef] [PubMed]

Park, S. Y.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, R. Richards-Kortum, “Design of a multispectral digital colposcope,” Proc. SPIE 6430, 64301S, 64301S-8 (2007).
[CrossRef]

Patterson, M. S.

B. W. Pogue, M. S. Patterson, “Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry,” J. Biomed. Opt. 11(4), 041102 (2006).
[CrossRef] [PubMed]

Paulsen, K. D.

Pietrzykowski, M.

A. M. De Grand, S. J. Lomnes, D. S. Lee, M. Pietrzykowski, S. Ohnishi, T. G. Morgan, A. Gogbashian, R. G. Laurence, J. V. Frangioni, “Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons,” J. Biomed. Opt. 11(1), 014007 (2006).
[CrossRef] [PubMed]

Pifferi, A.

Pikkula, B. M.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, R. Richards-Kortum, “Design of a multispectral digital colposcope,” Proc. SPIE 6430, 64301S, 64301S-8 (2007).
[CrossRef]

Pogue, B. W.

Poplack, S. P.

Prahl, S. A.

Richards-Kortum, R.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, R. Richards-Kortum, “Design of a multispectral digital colposcope,” Proc. SPIE 6430, 64301S, 64301S-8 (2007).
[CrossRef]

Serachitopol, D.

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, R. Richards-Kortum, “Design of a multispectral digital colposcope,” Proc. SPIE 6430, 64301S, 64301S-8 (2007).
[CrossRef]

Shah, N.

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

Srinivasan, S.

Stamm, H.

Sterenborg, H. J. C. M.

Svensson, T.

Swartling, J.

Tanamai, V. W.

A. E. Cerussi, V. W. Tanamai, D. Hsiang, J. Butler, R. S. Mehta, B. J. Tromberg, “Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy,” Philos. Transact. A Math. Phys. Eng. Sci. 369(1955), 4512–4530 (2011).
[CrossRef] [PubMed]

Taroni, P.

Torricelli, A.

Tromberg, B. J.

A. E. Cerussi, V. W. Tanamai, D. Hsiang, J. Butler, R. S. Mehta, B. J. Tromberg, “Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy,” Philos. Transact. A Math. Phys. Eng. Sci. 369(1955), 4512–4530 (2011).
[CrossRef] [PubMed]

S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang, B. J. Tromberg, “In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy,” Phys. Med. Biol. 53(23), 6713–6727 (2008).
[CrossRef] [PubMed]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Tualle, J.-M.

Utke, N.

G. Wagnières, S. Cheng, M. Zellweger, N. Utke, D. Braichotte, J.-P. Ballini, H. van den Bergh, “An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy,” Phys. Med. Biol. 42(7), 1415–1426 (1997).
[CrossRef] [PubMed]

Valentini, G.

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, G. Valentini, “A solid tissue phantom for photon migration studies,” Phys. Med. Biol. 42(10), 1971–1979 (1997).
[CrossRef] [PubMed]

van den Bergh, H.

G. Wagnières, S. Cheng, M. Zellweger, N. Utke, D. Braichotte, J.-P. Ballini, H. van den Bergh, “An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy,” Phys. Med. Biol. 42(7), 1415–1426 (1997).
[CrossRef] [PubMed]

van Gemert, M. J.

van Marie, J.

van Staveren, H. J.

van Veen, R. L. P.

vandeVen, M. J.

J. B. Fishkin, S. Fantini, M. J. vandeVen, E. Gratton, “Gigahertz photon density waves in a turbid medium: Theory and experiments,” Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics 53(3), 2307–2319 (1996).
[CrossRef] [PubMed]

Wabnitz, H.

Wagnières, G.

G. Wagnières, S. Cheng, M. Zellweger, N. Utke, D. Braichotte, J.-P. Ballini, H. van den Bergh, “An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy,” Phys. Med. Biol. 42(7), 1415–1426 (1997).
[CrossRef] [PubMed]

Weaver, J.

Whelan, M.

Zellweger, M.

G. Wagnières, S. Cheng, M. Zellweger, N. Utke, D. Braichotte, J.-P. Ballini, H. van den Bergh, “An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy,” Phys. Med. Biol. 42(7), 1415–1426 (1997).
[CrossRef] [PubMed]

Appl. Opt. (2)

J. Biomed. Opt. (3)

A. M. De Grand, S. J. Lomnes, D. S. Lee, M. Pietrzykowski, S. Ohnishi, T. G. Morgan, A. Gogbashian, R. G. Laurence, J. V. Frangioni, “Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons,” J. Biomed. Opt. 11(1), 014007 (2006).
[CrossRef] [PubMed]

B. W. Pogue, M. S. Patterson, “Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry,” J. Biomed. Opt. 11(4), 041102 (2006).
[CrossRef] [PubMed]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

Opt. Lett. (1)

Philos. Transact. A Math. Phys. Eng. Sci. (1)

A. E. Cerussi, V. W. Tanamai, D. Hsiang, J. Butler, R. S. Mehta, B. J. Tromberg, “Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy,” Philos. Transact. A Math. Phys. Eng. Sci. 369(1955), 4512–4530 (2011).
[CrossRef] [PubMed]

Phys. Med. Biol. (3)

S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang, B. J. Tromberg, “In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy,” Phys. Med. Biol. 53(23), 6713–6727 (2008).
[CrossRef] [PubMed]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, G. Valentini, “A solid tissue phantom for photon migration studies,” Phys. Med. Biol. 42(10), 1971–1979 (1997).
[CrossRef] [PubMed]

G. Wagnières, S. Cheng, M. Zellweger, N. Utke, D. Braichotte, J.-P. Ballini, H. van den Bergh, “An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy,” Phys. Med. Biol. 42(7), 1415–1426 (1997).
[CrossRef] [PubMed]

Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics (1)

J. B. Fishkin, S. Fantini, M. J. vandeVen, E. Gratton, “Gigahertz photon density waves in a turbid medium: Theory and experiments,” Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics 53(3), 2307–2319 (1996).
[CrossRef] [PubMed]

Proc. SPIE (1)

N. B. MacKinnon, M. Cardeno, S. Au, C. E. MacAulay, B. M. Pikkula, D. Serachitopol, M. Follen, S. Y. Park, R. Richards-Kortum, “Design of a multispectral digital colposcope,” Proc. SPIE 6430, 64301S, 64301S-8 (2007).
[CrossRef]

Technol. Cancer Res. Treat. (1)

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

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Figures (3)

Fig. 1
Fig. 1

Setup for calibration measurement. In order to measure the same phantom volume each time, a mask was prepared to fit the phantom (left) and lock the probe in place (right).

Fig. 2
Fig. 2

Drift tests for all DOSI instruments in ACRIN 6691. The percent change in optical properties for each laser diode measured over a 1 hour timeframe is presented for absorption (left) and reduced scattering (right).

Fig. 3
Fig. 3

Measured differences of 180 different phantom measurements at UC Irvine and Dartmouth. Overall the differences in absorption were on average~3.3% and the differences in reduced scattering were on average ~2.4%.

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