Abstract

Medical imaging is an invaluable tool for diagnosis, surgical guidance, and assessment of treatment efficacy. The Network for Translational Research (NTR) for Optical Imaging consists of four research groups working to “bridge the gap” between lab discovery and clinical use of fluorescence- and photoacoustic-based imaging devices used with imaging biomarkers. While the groups are using different modalities, all the groups face similar challenges when attempting to validate these systems for FDA approval and, ultimately, clinical use. Validation steps taken, as well as future needs, are described here. The group hopes to provide translational validation guidance for itself, as well as other researchers.

© 2012 OSA

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    [CrossRef] [PubMed]

2012

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

B. Zhu, I. C. Tan, J. C. Rasmussen, and E. M. Sevick-Muraca, “Validating the sensitivity and performance of near-infrared fluorescence imaging and tomography devices using a novel solid phantom and measurement approach,” Technol. Cancer Res. Treat.11(1), 95–104 (2012).
[PubMed]

2011

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

S. J. Miller, B. P. Joshi, Y. Feng, A. Gaustad, E. R. Fearon, and T. D. Wang, “In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe,” PLoS ONE6(3), e17384 (2011).
[CrossRef] [PubMed]

S. F. Elahi, S. J. Miller, B. Joshi, and T. D. Wang, “Targeted imaging of colorectal dysplasia in living mice with fluorescence microendoscopy,” Biomed. Opt. Express2(4), 981–986 (2011).
[CrossRef] [PubMed]

M. B. Aldrich, X. Wang, A. Hart, S. Kwon, L. Sampath, M. V. Marshall, and E. M. Sevick-Muraca, “Assessment of free dye in solutions of dual-labeled antibody conjugates for in vivo molecular imaging,” Mol. Imaging Biol.13(1), 32–42 (2011).
[CrossRef] [PubMed]

C. H. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held photoacoustic probe adapted from a clinical ultrasound system for non-invasive sentinel lymph node imaging,” Philos. Transact. A Math. Phys. Eng. Sci.369(1955), 4644–4650 (2011).
[CrossRef] [PubMed]

2010

C. H. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt.15(4), 046010 (2010).
[CrossRef] [PubMed]

C. H. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, K. E. Adams, S. Kwon, C. E. Fife, E. A. Maus, L. A. Smith, K. R. Covington, and E. M. Sevick-Muraca, “Human lymphatic architecture and dynamic transport imaged using near-infrared fluorescence,” Transl Oncol3(6), 362–372 (2010).
[PubMed]

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–317 (2010).
[PubMed]

M. V. Marshall, D. Draney, E. M. Sevick-Muraca, and D. M. Olive, “Single-dose intravenous toxicity study of IRDye 800CW in Sprague-Dawley rats,” Mol. Imaging Biol.12(6), 583–594 (2010).
[CrossRef] [PubMed]

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

M. Goetz and T. D. Wang, “Molecular imaging in gastrointestinal endoscopy,” Gastroenterology138(3), 828–833.e1 (2010).
[CrossRef] [PubMed]

B. P. Joshi and T. D. Wang, “Exogenous molecular probes for targeted imaging in cancer: focus on multi-modal imaging,” Cancers2(2), 1251–1288 (2010).
[CrossRef] [PubMed]

S. Gioux, H. S. Choi, and J. V. Frangioni, “Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation,” Mol. Imaging9(5), 237–255 (2010).
[PubMed]

2009

F. Wang, P. Hussels, and P. Liu, “Securely and flexibly sharing a biomedical data management system,” Proc. SPIE7264(726402), 1–8 (2009).
[PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, C. E. Fife, and E. M. Sevick-Muraca, “Lymphatic imaging in humans with near-infrared fluorescence,” Curr. Opin. Biotechnol.20(1), 74–82 (2009).
[CrossRef] [PubMed]

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics3(9), 503–509 (2009).
[CrossRef] [PubMed]

2008

L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys.35(12), 5758–5767 (2008).
[CrossRef] [PubMed]

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

P. L. Hsiung and T. D. Wang, “In vivo biomarkers for targeting colorectal neoplasms,” Cancer Biomark.4(6), 329–340 (2008).
[PubMed]

2007

W. A. Wells, P. E. Barker, C. MacAulay, M. Novelli, R. M. Levenson, and J. M. Crawford, “Validation of novel optical imaging technologies: the pathologists’ view,” J. Biomed. Opt.12(5), 051801 (2007).
[CrossRef] [PubMed]

2006

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

2005

A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois, “Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention,” J. Clin. Oncol.23(2), 254–266 (2005).
[CrossRef] [PubMed]

2003

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

2000

A. S. Kalgutkar, B. C. Crews, S. W. Rowlinson, A. B. Marnett, K. R. Kozak, R. P. Remmel, and L. J. Marnett, “Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors,” Proc. Natl. Acad. Sci. U.S.A.97(2), 925–930 (2000).
[CrossRef] [PubMed]

Achilefu, S.

C. H. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt.15(4), 046010 (2010).
[CrossRef] [PubMed]

Adams, K. E.

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, K. E. Adams, S. Kwon, C. E. Fife, E. A. Maus, L. A. Smith, K. R. Covington, and E. M. Sevick-Muraca, “Human lymphatic architecture and dynamic transport imaged using near-infrared fluorescence,” Transl Oncol3(6), 362–372 (2010).
[PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

Akers, W. J.

C. H. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt.15(4), 046010 (2010).
[CrossRef] [PubMed]

Aldrich, M. B.

Anderson, W. F.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Azhdarinia, A.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

Bagheri, D.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Barker, P. E.

W. A. Wells, P. E. Barker, C. MacAulay, M. Novelli, R. M. Levenson, and J. M. Crawford, “Validation of novel optical imaging technologies: the pathologists’ view,” J. Biomed. Opt.12(5), 051801 (2007).
[CrossRef] [PubMed]

Bedor, M.

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Bertagnolli, M. M.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Blobaum, A. L.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Boisserie, F.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Burn, J.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Chan, W.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

Choi, H. S.

S. Gioux, H. S. Choi, and J. V. Frangioni, “Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation,” Mol. Imaging9(5), 237–255 (2010).
[PubMed]

Chung, D. C.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Contag, C. H.

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Corle, D.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Covington, K. R.

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, K. E. Adams, S. Kwon, C. E. Fife, E. A. Maus, L. A. Smith, K. R. Covington, and E. M. Sevick-Muraca, “Human lymphatic architecture and dynamic transport imaged using near-infrared fluorescence,” Transl Oncol3(6), 362–372 (2010).
[PubMed]

Crawford, J. M.

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

W. A. Wells, P. E. Barker, C. MacAulay, M. Novelli, R. M. Levenson, and J. M. Crawford, “Validation of novel optical imaging technologies: the pathologists’ view,” J. Biomed. Opt.12(5), 051801 (2007).
[CrossRef] [PubMed]

Crews, B. C.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

A. S. Kalgutkar, B. C. Crews, S. W. Rowlinson, A. B. Marnett, K. R. Kozak, R. P. Remmel, and L. J. Marnett, “Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors,” Proc. Natl. Acad. Sci. U.S.A.97(2), 925–930 (2000).
[CrossRef] [PubMed]

Dannenberg, A. J.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois, “Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention,” J. Clin. Oncol.23(2), 254–266 (2005).
[CrossRef] [PubMed]

Darne, C.

Dewar, T.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Draney, D.

M. V. Marshall, D. Draney, E. M. Sevick-Muraca, and D. M. Olive, “Single-dose intravenous toxicity study of IRDye 800CW in Sprague-Dawley rats,” Mol. Imaging Biol.12(6), 583–594 (2010).
[CrossRef] [PubMed]

Du, C. B.

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

DuBois, R. N.

A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois, “Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention,” J. Clin. Oncol.23(2), 254–266 (2005).
[CrossRef] [PubMed]

Eagle, C. J.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Edelman, M. J.

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Elahi, S. F.

Erpelding, T. N.

C. H. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held photoacoustic probe adapted from a clinical ultrasound system for non-invasive sentinel lymph node imaging,” Philos. Transact. A Math. Phys. Eng. Sci.369(1955), 4644–4650 (2011).
[CrossRef] [PubMed]

C. H. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt.15(4), 046010 (2010).
[CrossRef] [PubMed]

C. H. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

Fearon, E. R.

S. J. Miller, B. P. Joshi, Y. Feng, A. Gaustad, E. R. Fearon, and T. D. Wang, “In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe,” PLoS ONE6(3), e17384 (2011).
[CrossRef] [PubMed]

Feng, Y.

S. J. Miller, B. P. Joshi, Y. Feng, A. Gaustad, E. R. Fearon, and T. D. Wang, “In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe,” PLoS ONE6(3), e17384 (2011).
[CrossRef] [PubMed]

Fife, C. E.

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, K. E. Adams, S. Kwon, C. E. Fife, E. A. Maus, L. A. Smith, K. R. Covington, and E. M. Sevick-Muraca, “Human lymphatic architecture and dynamic transport imaged using near-infrared fluorescence,” Transl Oncol3(6), 362–372 (2010).
[PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, C. E. Fife, and E. M. Sevick-Muraca, “Lymphatic imaging in humans with near-infrared fluorescence,” Curr. Opin. Biotechnol.20(1), 74–82 (2009).
[CrossRef] [PubMed]

Foley, T. R.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Frangioni, J. V.

S. Gioux, H. S. Choi, and J. V. Frangioni, “Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation,” Mol. Imaging9(5), 237–255 (2010).
[PubMed]

Friedland, S.

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Gajra, A.

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Gaustad, A.

S. J. Miller, B. P. Joshi, Y. Feng, A. Gaustad, E. R. Fearon, and T. D. Wang, “In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe,” PLoS ONE6(3), e17384 (2011).
[CrossRef] [PubMed]

S. J. Miller, C. M. Lee, B. P. Joshi, A. Gaustad, E. J. Seibel, and T. D. Wang, “Targeted detection of murine colonic dysplasia in vivo with flexible multi-spectral scanning fiber endoscopy,” J. Biomed. Opt. (to be published).

Gioux, S.

S. Gioux, H. S. Choi, and J. V. Frangioni, “Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation,” Mol. Imaging9(5), 237–255 (2010).
[PubMed]

Goetz, M.

M. Goetz and T. D. Wang, “Molecular imaging in gastrointestinal endoscopy,” Gastroenterology138(3), 828–833.e1 (2010).
[CrossRef] [PubMed]

Gorden, D. L.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Gordon, G. B.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Green, M. J.

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Guilloid, R.

Hall, M. A.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–317 (2010).
[PubMed]

Hardy, J.

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Hart, A.

M. B. Aldrich, X. Wang, A. Hart, S. Kwon, L. Sampath, M. V. Marshall, and E. M. Sevick-Muraca, “Assessment of free dye in solutions of dual-labeled antibody conjugates for in vivo molecular imaging,” Mol. Imaging Biol.13(1), 32–42 (2011).
[CrossRef] [PubMed]

Hawk, E. T.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Hess, T. M.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Hodgson, L.

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Hoffman, N.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Hoy, S.

Hsiung, P. L.

P. L. Hsiung and T. D. Wang, “In vivo biomarkers for targeting colorectal neoplasms,” Cancer Biomark.4(6), 329–340 (2008).
[PubMed]

Hsiung, P.-L.

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Hu, S.

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science (to be published).

Hussels, P.

F. Wang, P. Hussels, and P. Liu, “Securely and flexibly sharing a biomedical data management system,” Proc. SPIE7264(726402), 1–8 (2009).
[PubMed]

Jankovic, L.

C. H. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held photoacoustic probe adapted from a clinical ultrasound system for non-invasive sentinel lymph node imaging,” Philos. Transact. A Math. Phys. Eng. Sci.369(1955), 4644–4650 (2011).
[CrossRef] [PubMed]

C. H. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt.15(4), 046010 (2010).
[CrossRef] [PubMed]

C. H. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

Jewell, S.

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Joshi, B.

Joshi, B. P.

S. J. Miller, B. P. Joshi, Y. Feng, A. Gaustad, E. R. Fearon, and T. D. Wang, “In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe,” PLoS ONE6(3), e17384 (2011).
[CrossRef] [PubMed]

B. P. Joshi and T. D. Wang, “Exogenous molecular probes for targeted imaging in cancer: focus on multi-modal imaging,” Cancers2(2), 1251–1288 (2010).
[CrossRef] [PubMed]

S. J. Miller, C. M. Lee, B. P. Joshi, A. Gaustad, E. J. Seibel, and T. D. Wang, “Targeted detection of murine colonic dysplasia in vivo with flexible multi-spectral scanning fiber endoscopy,” J. Biomed. Opt. (to be published).

Kalgutkar, A. S.

A. S. Kalgutkar, B. C. Crews, S. W. Rowlinson, A. B. Marnett, K. R. Kozak, R. P. Remmel, and L. J. Marnett, “Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors,” Proc. Natl. Acad. Sci. U.S.A.97(2), 925–930 (2000).
[CrossRef] [PubMed]

Kim, C. H.

C. H. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held photoacoustic probe adapted from a clinical ultrasound system for non-invasive sentinel lymph node imaging,” Philos. Transact. A Math. Phys. Eng. Sci.369(1955), 4644–4650 (2011).
[CrossRef] [PubMed]

C. H. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt.15(4), 046010 (2010).
[CrossRef] [PubMed]

C. H. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

Kim, K.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Kingsley, P. J.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Kozak, K. R.

A. S. Kalgutkar, B. C. Crews, S. W. Rowlinson, A. B. Marnett, K. R. Kozak, R. P. Remmel, and L. J. Marnett, “Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors,” Proc. Natl. Acad. Sci. U.S.A.97(2), 925–930 (2000).
[CrossRef] [PubMed]

Kratzke, R. A.

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Ku, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Kwon, S.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

M. B. Aldrich, X. Wang, A. Hart, S. Kwon, L. Sampath, M. V. Marshall, and E. M. Sevick-Muraca, “Assessment of free dye in solutions of dual-labeled antibody conjugates for in vivo molecular imaging,” Mol. Imaging Biol.13(1), 32–42 (2011).
[CrossRef] [PubMed]

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–317 (2010).
[PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, K. E. Adams, S. Kwon, C. E. Fife, E. A. Maus, L. A. Smith, K. R. Covington, and E. M. Sevick-Muraca, “Human lymphatic architecture and dynamic transport imaged using near-infrared fluorescence,” Transl Oncol3(6), 362–372 (2010).
[PubMed]

Lachance, P. A.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

Lee, C. M.

S. J. Miller, C. M. Lee, B. P. Joshi, A. Gaustad, E. J. Seibel, and T. D. Wang, “Targeted detection of murine colonic dysplasia in vivo with flexible multi-spectral scanning fiber endoscopy,” J. Biomed. Opt. (to be published).

Levenson, R. M.

W. A. Wells, P. E. Barker, C. MacAulay, M. Novelli, R. M. Levenson, and J. M. Crawford, “Validation of novel optical imaging technologies: the pathologists’ view,” J. Biomed. Opt.12(5), 051801 (2007).
[CrossRef] [PubMed]

Lippman, S. M.

A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois, “Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention,” J. Clin. Oncol.23(2), 254–266 (2005).
[CrossRef] [PubMed]

Liu, P.

F. Wang, P. Hussels, and P. Liu, “Securely and flexibly sharing a biomedical data management system,” Proc. SPIE7264(726402), 1–8 (2009).
[PubMed]

Lowe, A. W.

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

MacAulay, C.

W. A. Wells, P. E. Barker, C. MacAulay, M. Novelli, R. M. Levenson, and J. M. Crawford, “Validation of novel optical imaging technologies: the pathologists’ view,” J. Biomed. Opt.12(5), 051801 (2007).
[CrossRef] [PubMed]

Macrae, F.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Mann, J. R.

A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois, “Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention,” J. Clin. Oncol.23(2), 254–266 (2005).
[CrossRef] [PubMed]

Margenthaler, J. A.

C. H. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt.15(4), 046010 (2010).
[CrossRef] [PubMed]

Marnett, A. B.

A. S. Kalgutkar, B. C. Crews, S. W. Rowlinson, A. B. Marnett, K. R. Kozak, R. P. Remmel, and L. J. Marnett, “Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors,” Proc. Natl. Acad. Sci. U.S.A.97(2), 925–930 (2000).
[CrossRef] [PubMed]

Marnett, L. J.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

A. S. Kalgutkar, B. C. Crews, S. W. Rowlinson, A. B. Marnett, K. R. Kozak, R. P. Remmel, and L. J. Marnett, “Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors,” Proc. Natl. Acad. Sci. U.S.A.97(2), 925–930 (2000).
[CrossRef] [PubMed]

Marshall, M. V.

M. B. Aldrich, X. Wang, A. Hart, S. Kwon, L. Sampath, M. V. Marshall, and E. M. Sevick-Muraca, “Assessment of free dye in solutions of dual-labeled antibody conjugates for in vivo molecular imaging,” Mol. Imaging Biol.13(1), 32–42 (2011).
[CrossRef] [PubMed]

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, K. E. Adams, S. Kwon, C. E. Fife, E. A. Maus, L. A. Smith, K. R. Covington, and E. M. Sevick-Muraca, “Human lymphatic architecture and dynamic transport imaged using near-infrared fluorescence,” Transl Oncol3(6), 362–372 (2010).
[PubMed]

M. V. Marshall, D. Draney, E. M. Sevick-Muraca, and D. M. Olive, “Single-dose intravenous toxicity study of IRDye 800CW in Sprague-Dawley rats,” Mol. Imaging Biol.12(6), 583–594 (2010).
[CrossRef] [PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, C. E. Fife, and E. M. Sevick-Muraca, “Lymphatic imaging in humans with near-infrared fluorescence,” Curr. Opin. Biotechnol.20(1), 74–82 (2009).
[CrossRef] [PubMed]

Maslov, K.

C. H. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt.15(4), 046010 (2010).
[CrossRef] [PubMed]

Masters, G. A.

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Matrisian, L. M.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Mauer, A. M.

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Maus, E. A.

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, K. E. Adams, S. Kwon, C. E. Fife, E. A. Maus, L. A. Smith, K. R. Covington, and E. M. Sevick-Muraca, “Human lymphatic architecture and dynamic transport imaged using near-infrared fluorescence,” Transl Oncol3(6), 362–372 (2010).
[PubMed]

McIntyre, J. O.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Miller, S. J.

S. J. Miller, B. P. Joshi, Y. Feng, A. Gaustad, E. R. Fearon, and T. D. Wang, “In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe,” PLoS ONE6(3), e17384 (2011).
[CrossRef] [PubMed]

S. F. Elahi, S. J. Miller, B. Joshi, and T. D. Wang, “Targeted imaging of colorectal dysplasia in living mice with fluorescence microendoscopy,” Biomed. Opt. Express2(4), 981–986 (2011).
[CrossRef] [PubMed]

S. J. Miller, C. M. Lee, B. P. Joshi, A. Gaustad, E. J. Seibel, and T. D. Wang, “Targeted detection of murine colonic dysplasia in vivo with flexible multi-spectral scanning fiber endoscopy,” J. Biomed. Opt. (to be published).

Morrison, C.

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Novelli, M.

W. A. Wells, P. E. Barker, C. MacAulay, M. Novelli, R. M. Levenson, and J. M. Crawford, “Validation of novel optical imaging technologies: the pathologists’ view,” J. Biomed. Opt.12(5), 051801 (2007).
[CrossRef] [PubMed]

Olive, D. M.

M. V. Marshall, D. Draney, E. M. Sevick-Muraca, and D. M. Olive, “Single-dose intravenous toxicity study of IRDye 800CW in Sprague-Dawley rats,” Mol. Imaging Biol.12(6), 583–594 (2010).
[CrossRef] [PubMed]

Pang, Y.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Pashley, M. D.

C. H. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

C. H. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt.15(4), 046010 (2010).
[CrossRef] [PubMed]

Piston, D. W.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Price, R. E.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–317 (2010).
[PubMed]

Pruitt, R. E.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Ranganathan, R.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

Rasmussen, J. C.

B. Zhu, I. C. Tan, J. C. Rasmussen, and E. M. Sevick-Muraca, “Validating the sensitivity and performance of near-infrared fluorescence imaging and tomography devices using a novel solid phantom and measurement approach,” Technol. Cancer Res. Treat.11(1), 95–104 (2012).
[PubMed]

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, K. E. Adams, S. Kwon, C. E. Fife, E. A. Maus, L. A. Smith, K. R. Covington, and E. M. Sevick-Muraca, “Human lymphatic architecture and dynamic transport imaged using near-infrared fluorescence,” Transl Oncol3(6), 362–372 (2010).
[PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, C. E. Fife, and E. M. Sevick-Muraca, “Lymphatic imaging in humans with near-infrared fluorescence,” Curr. Opin. Biotechnol.20(1), 74–82 (2009).
[CrossRef] [PubMed]

Redston, M.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Remmel, R. P.

A. S. Kalgutkar, B. C. Crews, S. W. Rowlinson, A. B. Marnett, K. R. Kozak, R. P. Remmel, and L. J. Marnett, “Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors,” Proc. Natl. Acad. Sci. U.S.A.97(2), 925–930 (2000).
[CrossRef] [PubMed]

Robinson, H.

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

Rosenstein, R. B.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Rowlinson, S. W.

A. S. Kalgutkar, B. C. Crews, S. W. Rowlinson, A. B. Marnett, K. R. Kozak, R. P. Remmel, and L. J. Marnett, “Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors,” Proc. Natl. Acad. Sci. U.S.A.97(2), 925–930 (2000).
[CrossRef] [PubMed]

Sahbaie, P.

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Saltzman, J. R.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Salzberg, B.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Sampath, L.

M. B. Aldrich, X. Wang, A. Hart, S. Kwon, L. Sampath, M. V. Marshall, and E. M. Sevick-Muraca, “Assessment of free dye in solutions of dual-labeled antibody conjugates for in vivo molecular imaging,” Mol. Imaging Biol.13(1), 32–42 (2011).
[CrossRef] [PubMed]

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–317 (2010).
[PubMed]

Seibel, E. J.

S. J. Miller, C. M. Lee, B. P. Joshi, A. Gaustad, E. J. Seibel, and T. D. Wang, “Targeted detection of murine colonic dysplasia in vivo with flexible multi-spectral scanning fiber endoscopy,” J. Biomed. Opt. (to be published).

Sevick-Muraca, E. M.

B. Zhu, I. C. Tan, J. C. Rasmussen, and E. M. Sevick-Muraca, “Validating the sensitivity and performance of near-infrared fluorescence imaging and tomography devices using a novel solid phantom and measurement approach,” Technol. Cancer Res. Treat.11(1), 95–104 (2012).
[PubMed]

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

M. B. Aldrich, X. Wang, A. Hart, S. Kwon, L. Sampath, M. V. Marshall, and E. M. Sevick-Muraca, “Assessment of free dye in solutions of dual-labeled antibody conjugates for in vivo molecular imaging,” Mol. Imaging Biol.13(1), 32–42 (2011).
[CrossRef] [PubMed]

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, K. E. Adams, S. Kwon, C. E. Fife, E. A. Maus, L. A. Smith, K. R. Covington, and E. M. Sevick-Muraca, “Human lymphatic architecture and dynamic transport imaged using near-infrared fluorescence,” Transl Oncol3(6), 362–372 (2010).
[PubMed]

M. V. Marshall, D. Draney, E. M. Sevick-Muraca, and D. M. Olive, “Single-dose intravenous toxicity study of IRDye 800CW in Sprague-Dawley rats,” Mol. Imaging Biol.12(6), 583–594 (2010).
[CrossRef] [PubMed]

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–317 (2010).
[PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, C. E. Fife, and E. M. Sevick-Muraca, “Lymphatic imaging in humans with near-infrared fluorescence,” Curr. Opin. Biotechnol.20(1), 74–82 (2009).
[CrossRef] [PubMed]

Smith, L. A.

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, K. E. Adams, S. Kwon, C. E. Fife, E. A. Maus, L. A. Smith, K. R. Covington, and E. M. Sevick-Muraca, “Human lymphatic architecture and dynamic transport imaged using near-infrared fluorescence,” Transl Oncol3(6), 362–372 (2010).
[PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

Soetikno, R.

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Solomon, S. D.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Song, L.

C. H. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt.15(4), 046010 (2010).
[CrossRef] [PubMed]

Stoica, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Subbaramaiah, K.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois, “Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention,” J. Clin. Oncol.23(2), 254–266 (2005).
[CrossRef] [PubMed]

Sylwestrowicz, T.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Tan, I. C.

B. Zhu, I. C. Tan, J. C. Rasmussen, and E. M. Sevick-Muraca, “Validating the sensitivity and performance of near-infrared fluorescence imaging and tomography devices using a novel solid phantom and measurement approach,” Technol. Cancer Res. Treat.11(1), 95–104 (2012).
[PubMed]

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

K. E. Adams, J. C. Rasmussen, C. Darne, I. C. Tan, M. B. Aldrich, M. V. Marshall, C. E. Fife, E. A. Maus, L. A. Smith, R. Guilloid, S. Hoy, and E. M. Sevick-Muraca, “Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema,” Biomed. Opt. Express1(1), 114–125 (2010).
[CrossRef] [PubMed]

Tan, I.-C.

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, K. E. Adams, S. Kwon, C. E. Fife, E. A. Maus, L. A. Smith, K. R. Covington, and E. M. Sevick-Muraca, “Human lymphatic architecture and dynamic transport imaged using near-infrared fluorescence,” Transl Oncol3(6), 362–372 (2010).
[PubMed]

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, C. E. Fife, and E. M. Sevick-Muraca, “Lymphatic imaging in humans with near-infrared fluorescence,” Curr. Opin. Biotechnol.20(1), 74–82 (2009).
[CrossRef] [PubMed]

Tang, J.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Uddin, M. J.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Viner, J. L.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Vokes, E. E.

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Wang, F.

F. Wang, P. Hussels, and P. Liu, “Securely and flexibly sharing a biomedical data management system,” Proc. SPIE7264(726402), 1–8 (2009).
[PubMed]

Wang, L. V.

C. H. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held photoacoustic probe adapted from a clinical ultrasound system for non-invasive sentinel lymph node imaging,” Philos. Transact. A Math. Phys. Eng. Sci.369(1955), 4644–4650 (2011).
[CrossRef] [PubMed]

C. H. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt.15(4), 046010 (2010).
[CrossRef] [PubMed]

C. H. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics3(9), 503–509 (2009).
[CrossRef] [PubMed]

L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys.35(12), 5758–5767 (2008).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science (to be published).

Wang, T. D.

S. F. Elahi, S. J. Miller, B. Joshi, and T. D. Wang, “Targeted imaging of colorectal dysplasia in living mice with fluorescence microendoscopy,” Biomed. Opt. Express2(4), 981–986 (2011).
[CrossRef] [PubMed]

S. J. Miller, B. P. Joshi, Y. Feng, A. Gaustad, E. R. Fearon, and T. D. Wang, “In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe,” PLoS ONE6(3), e17384 (2011).
[CrossRef] [PubMed]

B. P. Joshi and T. D. Wang, “Exogenous molecular probes for targeted imaging in cancer: focus on multi-modal imaging,” Cancers2(2), 1251–1288 (2010).
[CrossRef] [PubMed]

M. Goetz and T. D. Wang, “Molecular imaging in gastrointestinal endoscopy,” Gastroenterology138(3), 828–833.e1 (2010).
[CrossRef] [PubMed]

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

P. L. Hsiung and T. D. Wang, “In vivo biomarkers for targeting colorectal neoplasms,” Cancer Biomark.4(6), 329–340 (2008).
[PubMed]

S. J. Miller, C. M. Lee, B. P. Joshi, A. Gaustad, E. J. Seibel, and T. D. Wang, “Targeted detection of murine colonic dysplasia in vivo with flexible multi-spectral scanning fiber endoscopy,” J. Biomed. Opt. (to be published).

Wang, X.

M. B. Aldrich, X. Wang, A. Hart, S. Kwon, L. Sampath, M. V. Marshall, and E. M. Sevick-Muraca, “Assessment of free dye in solutions of dual-labeled antibody conjugates for in vivo molecular imaging,” Mol. Imaging Biol.13(1), 32–42 (2011).
[CrossRef] [PubMed]

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Watson, D.

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Wells, W. A.

W. A. Wells, P. E. Barker, C. MacAulay, M. Novelli, R. M. Levenson, and J. M. Crawford, “Validation of novel optical imaging technologies: the pathologists’ view,” J. Biomed. Opt.12(5), 051801 (2007).
[CrossRef] [PubMed]

Wittes, J.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Woloj, G. M.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Wu, A. P.

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Xie, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Zauber, A. G.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Zhu, B.

B. Zhu, I. C. Tan, J. C. Rasmussen, and E. M. Sevick-Muraca, “Validating the sensitivity and performance of near-infrared fluorescence imaging and tomography devices using a novel solid phantom and measurement approach,” Technol. Cancer Res. Treat.11(1), 95–104 (2012).
[PubMed]

Arch. Phys. Med. Rehabil.

I. C. Tan, E. A. Maus, J. C. Rasmussen, M. V. Marshall, K. E. Adams, C. E. Fife, L. A. Smith, W. Chan, and E. M. Sevick-Muraca, “Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging,” Arch. Phys. Med. Rehabil.92(5), 756–764.e1 (2011).
[CrossRef] [PubMed]

Biomed. Opt. Express

Cancer Biomark.

P. L. Hsiung and T. D. Wang, “In vivo biomarkers for targeting colorectal neoplasms,” Cancer Biomark.4(6), 329–340 (2008).
[PubMed]

Cancer Res.

M. J. Uddin, B. C. Crews, A. L. Blobaum, P. J. Kingsley, D. L. Gorden, J. O. McIntyre, L. M. Matrisian, K. Subbaramaiah, A. J. Dannenberg, D. W. Piston, and L. J. Marnett, “Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents,” Cancer Res.70(9), 3618–3627 (2010).
[CrossRef] [PubMed]

Cancers

B. P. Joshi and T. D. Wang, “Exogenous molecular probes for targeted imaging in cancer: focus on multi-modal imaging,” Cancers2(2), 1251–1288 (2010).
[CrossRef] [PubMed]

Curr. Opin. Biotechnol.

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, C. E. Fife, and E. M. Sevick-Muraca, “Lymphatic imaging in humans with near-infrared fluorescence,” Curr. Opin. Biotechnol.20(1), 74–82 (2009).
[CrossRef] [PubMed]

Gastroenterology

M. Goetz and T. D. Wang, “Molecular imaging in gastrointestinal endoscopy,” Gastroenterology138(3), 828–833.e1 (2010).
[CrossRef] [PubMed]

J. Biomed. Opt.

C. H. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt.15(4), 046010 (2010).
[CrossRef] [PubMed]

S. J. Miller, C. M. Lee, B. P. Joshi, A. Gaustad, E. J. Seibel, and T. D. Wang, “Targeted detection of murine colonic dysplasia in vivo with flexible multi-spectral scanning fiber endoscopy,” J. Biomed. Opt. (to be published).

W. A. Wells, P. E. Barker, C. MacAulay, M. Novelli, R. M. Levenson, and J. M. Crawford, “Validation of novel optical imaging technologies: the pathologists’ view,” J. Biomed. Opt.12(5), 051801 (2007).
[CrossRef] [PubMed]

J. Clin. Oncol.

A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois, “Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention,” J. Clin. Oncol.23(2), 254–266 (2005).
[CrossRef] [PubMed]

M. J. Edelman, D. Watson, X. Wang, C. Morrison, R. A. Kratzke, S. Jewell, L. Hodgson, A. M. Mauer, A. Gajra, G. A. Masters, M. Bedor, E. E. Vokes, and M. J. Green, “Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203,” J. Clin. Oncol.26(6), 848–855 (2008).
[CrossRef] [PubMed]

Med. Phys.

L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys.35(12), 5758–5767 (2008).
[CrossRef] [PubMed]

Mol. Imaging

S. Gioux, H. S. Choi, and J. V. Frangioni, “Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation,” Mol. Imaging9(5), 237–255 (2010).
[PubMed]

Mol. Imaging Biol.

M. B. Aldrich, X. Wang, A. Hart, S. Kwon, L. Sampath, M. V. Marshall, and E. M. Sevick-Muraca, “Assessment of free dye in solutions of dual-labeled antibody conjugates for in vivo molecular imaging,” Mol. Imaging Biol.13(1), 32–42 (2011).
[CrossRef] [PubMed]

M. V. Marshall, D. Draney, E. M. Sevick-Muraca, and D. M. Olive, “Single-dose intravenous toxicity study of IRDye 800CW in Sprague-Dawley rats,” Mol. Imaging Biol.12(6), 583–594 (2010).
[CrossRef] [PubMed]

N. Engl. J. Med.

M. M. Bertagnolli, C. J. Eagle, A. G. Zauber, M. Redston, S. D. Solomon, K. Kim, J. Tang, R. B. Rosenstein, J. Wittes, D. Corle, T. M. Hess, G. M. Woloj, F. Boisserie, W. F. Anderson, J. L. Viner, D. Bagheri, J. Burn, D. C. Chung, T. Dewar, T. R. Foley, N. Hoffman, F. Macrae, R. E. Pruitt, J. R. Saltzman, B. Salzberg, T. Sylwestrowicz, G. B. Gordon, E. T. Hawk, and APC Study Investigators, “Celecoxib for the prevention of sporadic colorectal adenomas,” N. Engl. J. Med.355(9), 873–874 (2006).
[CrossRef]

Nat. Biotechnol.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Nat. Med.

P.-L. Hsiung, J. Hardy, S. Friedland, R. Soetikno, C. B. Du, A. P. Wu, P. Sahbaie, J. M. Crawford, A. W. Lowe, C. H. Contag, and T. D. Wang, “Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy,” Nat. Med.14(4), 454–458 (2008).
[CrossRef] [PubMed]

Nat. Photonics

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics3(9), 503–509 (2009).
[CrossRef] [PubMed]

Philos. Transact. A Math. Phys. Eng. Sci.

C. H. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held photoacoustic probe adapted from a clinical ultrasound system for non-invasive sentinel lymph node imaging,” Philos. Transact. A Math. Phys. Eng. Sci.369(1955), 4644–4650 (2011).
[CrossRef] [PubMed]

PLoS ONE

S. J. Miller, B. P. Joshi, Y. Feng, A. Gaustad, E. R. Fearon, and T. D. Wang, “In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe,” PLoS ONE6(3), e17384 (2011).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. U.S.A.

A. S. Kalgutkar, B. C. Crews, S. W. Rowlinson, A. B. Marnett, K. R. Kozak, R. P. Remmel, and L. J. Marnett, “Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors,” Proc. Natl. Acad. Sci. U.S.A.97(2), 925–930 (2000).
[CrossRef] [PubMed]

Proc. SPIE

F. Wang, P. Hussels, and P. Liu, “Securely and flexibly sharing a biomedical data management system,” Proc. SPIE7264(726402), 1–8 (2009).
[PubMed]

Prostate

M. A. Hall, S. Kwon, H. Robinson, P. A. Lachance, A. Azhdarinia, R. Ranganathan, R. E. Price, W. Chan, and E. M. Sevick-Muraca, “Imaging prostate cancer lymph node metastases with a multimodality contrast agent,” Prostate72(2), 129–146 (2012).
[CrossRef] [PubMed]

Science

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science (to be published).

Technol. Cancer Res. Treat.

B. Zhu, I. C. Tan, J. C. Rasmussen, and E. M. Sevick-Muraca, “Validating the sensitivity and performance of near-infrared fluorescence imaging and tomography devices using a novel solid phantom and measurement approach,” Technol. Cancer Res. Treat.11(1), 95–104 (2012).
[PubMed]

Transl Oncol

J. C. Rasmussen, I.-C. Tan, M. V. Marshall, K. E. Adams, S. Kwon, C. E. Fife, E. A. Maus, L. A. Smith, K. R. Covington, and E. M. Sevick-Muraca, “Human lymphatic architecture and dynamic transport imaged using near-infrared fluorescence,” Transl Oncol3(6), 362–372 (2010).
[PubMed]

L. Sampath, S. Kwon, M. A. Hall, R. E. Price, and E. M. Sevick-Muraca, “Detection of cancer metastases with a dual-labeled near-infrared/positron emission tomography imaging agent,” Transl Oncol3(5), 307–317 (2010).
[PubMed]

Other

Network for Translational Research, Handbook for NTR Investigators (Nov. 9, 2010), http://ntroi.wustl.edu/wiki/ntroi/images/d/d7/Handbook_for_NTR_Investigators_110910_for_upload.pdf .

T. D. Wang, “Targeted imaging of flat and depressed colonic neoplasms,” in Non-Polypoid (Flat and Depressed) Colorectal Neoplasms. Gastrointestinal Endoscopy Clinics of North America, R. M. Soetikno and T. Kaltenbach, eds. (Elsevier Saunders, 2010).

M. Li and T. D. Wang, “Targeted endoscopic imaging,” in Enhanced Endoscopic Imaging. Gastrointestinal Endoscopy Clinics of North America, K. Wang and G. Elta, eds. (Elsevier Saunders, 2009).

T. D. Wang, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA, is preparing a manuscript to be called “Phase 1 study of molecular probes to colonic dysplasia.”

S. S. Mehta, Commercializing Successful Biomedical Technologies (Cambridge University Press, 2008).

S. L. Gibbs-Strauss, M. Rosenberg, B. L. Clough, S. L. Troyan, and J. V. Frangioni, “First-in-human clinical trials of imaging devices: an example from optical imaging,” in Annual International Conference of the IEEE Engineering in Medicine and Biology Society,2009. EMBC 2009 (IEEE, 2009), pp. 2001–2004.

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Figures (5)

Fig. 1
Fig. 1

(top) Tissue penetration versus resolution for SW-PAM, sub-wavelength photoacoustic microscopy; SM-PAM, sub-micron photoacoustic microscopy; OR-PAM, optical-resolution photoacoustic microscopy; AR-PAM, acoustic-resolution photoacoustic microscopy; AR-PAMac, acoustic-resolution photoacoustic macroscopy; and LA-PACT, linear-array photoacoustic computed tomography; (bottom) in vivo multiscale photoacoustic images at organelle, cell, tissue, and organ scales.

Fig. 2
Fig. 2

Near-infrared fluorescence imaging of human lymphatics utilizes laser illumination of intradermally injected fluorescent dye; (left) fluorophore emissions are captured by an imaging system and ICCD (intensified charge-coupled device) camera, producing real-time images and movies of lymphatic vessel architecture and function, such as the image (right) of ventral forearm lymphatic vessels, yellow scale bar = 5 cm.

Fig. 3
Fig. 3

Fluorocoxib A, a COX-2-targeting peptide (top); and bioluminescent identification of dorsal mouse tumor (marked with white arrow in bottom image, with minor liver fluorescence) utilizing this COX-2-targeting peptide as the imaging agent.

Fig. 4
Fig. 4

Schematic of endoscopic multispectral imaging system (top); and (bottom) fluorescent and white light images of highly specific peptide targeting of colonic dysplasia (arrows) using (left to right) 440, 532, and 635 nm excitation [26].

Fig. 5
Fig. 5

The translation pipeline and validation needs. Some validation steps are needed throughout the translation process, and some steps are only necessary during portions of the process. Design iterations are designated by arched arrows.

Tables (1)

Tables Icon

Table 1 NTR Centers, imaging modalities, applications, and validation needs

Metrics