Abstract

Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for biomedical imaging. Here we show that combining it with structured illumination fluorescence microscopy on one platform can increase its versatility since it enables co-localized registration of optically sectioned reflectance and fluorescence images. To demonstrate the potential of this dual modality, a fixed and labeled mouse retina was imaged. Results showed that both techniques can provide complementary information and therefore the system could potentially be useful for biomedical imaging applications.

© 2012 OSA

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2011 (4)

M. Jain, N. Shukla, M. Manzoor, S. Nadolny, and S. Mukherjee, “Modified full-field optical coherence tomography: A novel tool for rapid histology of tissues,” J Pathol Inform2(1), 28 (2011).
[CrossRef] [PubMed]

J. Ben Arous, J. Binding, J. F. Léger, M. Casado, P. Topilko, S. Gigan, A. C. Boccara, and L. Bourdieu, “Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy,” J. Biomed. Opt.16(11), 116012 (2011).
[CrossRef] [PubMed]

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

A. Latrive and A. C. Boccara, “In vivo and in situ cellular imaging full-field optical coherence tomography with a rigid endoscopic probe,” Biomed. Opt. Express2(10), 2897–2904 (2011).
[CrossRef] [PubMed]

2010 (1)

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

2009 (1)

K. M. Connor, N. M. Krah, R. J. Dennison, C. M. Aderman, J. Chen, K. I. Guerin, P. Sapieha, A. Stahl, K. L. Willett, and L. E. Smith, “Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis,” Nat. Protoc.4(11), 1565–1573 (2009).
[CrossRef] [PubMed]

2008 (2)

D. Karadaglić and T. Wilson, “Image formation in structured illumination wide-field fluorescence microscopy,” Micron39(7), 808–818 (2008).
[CrossRef] [PubMed]

N. Bozinovic, C. Ventalon, T. Ford, and J. Mertz, “Fluorescence endomicroscopy with structured illumination,” Opt. Express16(11), 8016–8025 (2008).
[CrossRef] [PubMed]

2006 (3)

2004 (3)

J. F. Le Gargasson, K. Grieve, M. Paques, A. Dubois, and C. Boccara, “Imaging of ocular tissues using ultrahigh resolution full-field optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45, E-Abstract 2784 (2004).

A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, “Three-dimensional cellular-level imaging using full-field optical coherence tomography,” Phys. Med. Biol.49(7), 1227–1234 (2004).
[CrossRef] [PubMed]

A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, “Ultrahigh-resolution full-field optical coherence tomography,” Appl. Opt.43(14), 2874–2883 (2004).
[CrossRef] [PubMed]

2002 (4)

L. Vabre, A. Dubois, and A. C. Boccara, “Thermal-light full-field optical coherence tomography,” Opt. Lett.27(7), 530–532 (2002).
[CrossRef] [PubMed]

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

A. Dubois, L. Vabre, A. C. Boccara, and E. Beaurepaire, “High-resolution full-field optical coherence tomography with a Linnik microscope,” Appl. Opt.41(4), 805–812 (2002).
[CrossRef] [PubMed]

D. Karadaglić, R. Juškaitis, and T. Wilson, “Confocal endoscopy via structured illumination,” Scanning24(6), 301–304 (2002).
[CrossRef] [PubMed]

2001 (1)

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

2000 (1)

M. A. Neil, A. Squire, R. Juškaitis, P. I. Bastiaens, and T. Wilson, “Wide-field optically sectioning fluorescence microscopy with laser illumination,” J. Microsc.197(1), 1–4 (2000).
[CrossRef] [PubMed]

1999 (1)

1998 (1)

1997 (1)

Aderman, C. M.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

K. M. Connor, N. M. Krah, R. J. Dennison, C. M. Aderman, J. Chen, K. I. Guerin, P. Sapieha, A. Stahl, K. L. Willett, and L. E. Smith, “Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis,” Nat. Protoc.4(11), 1565–1573 (2009).
[CrossRef] [PubMed]

Amblard, F.

Bastiaens, P. I.

M. A. Neil, A. Squire, R. Juškaitis, P. I. Bastiaens, and T. Wilson, “Wide-field optically sectioning fluorescence microscopy with laser illumination,” J. Microsc.197(1), 1–4 (2000).
[CrossRef] [PubMed]

Beaurepaire, E.

Ben Arous, J.

J. Ben Arous, J. Binding, J. F. Léger, M. Casado, P. Topilko, S. Gigan, A. C. Boccara, and L. Bourdieu, “Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy,” J. Biomed. Opt.16(11), 116012 (2011).
[CrossRef] [PubMed]

Binding, J.

J. Ben Arous, J. Binding, J. F. Léger, M. Casado, P. Topilko, S. Gigan, A. C. Boccara, and L. Bourdieu, “Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy,” J. Biomed. Opt.16(11), 116012 (2011).
[CrossRef] [PubMed]

Blanchot, L.

Boccara, A. C.

Boccara, C.

A. Dubois, G. Moneron, and C. Boccara, “Thermal-light full-field optical coherence tomography in the 1.2 µm wavelength region,” Opt. Commun.266(2), 738–743 (2006).
[CrossRef]

J. F. Le Gargasson, K. Grieve, M. Paques, A. Dubois, and C. Boccara, “Imaging of ocular tissues using ultrahigh resolution full-field optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45, E-Abstract 2784 (2004).

A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, “Ultrahigh-resolution full-field optical coherence tomography,” Appl. Opt.43(14), 2874–2883 (2004).
[CrossRef] [PubMed]

Bouma, B. E.

Bourdieu, L.

J. Ben Arous, J. Binding, J. F. Léger, M. Casado, P. Topilko, S. Gigan, A. C. Boccara, and L. Bourdieu, “Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy,” J. Biomed. Opt.16(11), 116012 (2011).
[CrossRef] [PubMed]

Bozinovic, N.

Casado, M.

J. Ben Arous, J. Binding, J. F. Léger, M. Casado, P. Topilko, S. Gigan, A. C. Boccara, and L. Bourdieu, “Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy,” J. Biomed. Opt.16(11), 116012 (2011).
[CrossRef] [PubMed]

Chen, J.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

K. M. Connor, N. M. Krah, R. J. Dennison, C. M. Aderman, J. Chen, K. I. Guerin, P. Sapieha, A. Stahl, K. L. Willett, and L. E. Smith, “Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis,” Nat. Protoc.4(11), 1565–1573 (2009).
[CrossRef] [PubMed]

Cole, M. J.

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

Connor, K. M.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

K. M. Connor, N. M. Krah, R. J. Dennison, C. M. Aderman, J. Chen, K. I. Guerin, P. Sapieha, A. Stahl, K. L. Willett, and L. E. Smith, “Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis,” Nat. Protoc.4(11), 1565–1573 (2009).
[CrossRef] [PubMed]

Dayel, M. J.

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

Dennison, R. J.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

K. M. Connor, N. M. Krah, R. J. Dennison, C. M. Aderman, J. Chen, K. I. Guerin, P. Sapieha, A. Stahl, K. L. Willett, and L. E. Smith, “Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis,” Nat. Protoc.4(11), 1565–1573 (2009).
[CrossRef] [PubMed]

Dowling, K.

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

Dubois, A.

A. Dubois, G. Moneron, and C. Boccara, “Thermal-light full-field optical coherence tomography in the 1.2 µm wavelength region,” Opt. Commun.266(2), 738–743 (2006).
[CrossRef]

J. F. Le Gargasson, K. Grieve, M. Paques, A. Dubois, and C. Boccara, “Imaging of ocular tissues using ultrahigh resolution full-field optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45, E-Abstract 2784 (2004).

A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, “Ultrahigh-resolution full-field optical coherence tomography,” Appl. Opt.43(14), 2874–2883 (2004).
[CrossRef] [PubMed]

A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, “Three-dimensional cellular-level imaging using full-field optical coherence tomography,” Phys. Med. Biol.49(7), 1227–1234 (2004).
[CrossRef] [PubMed]

A. Dubois, L. Vabre, A. C. Boccara, and E. Beaurepaire, “High-resolution full-field optical coherence tomography with a Linnik microscope,” Appl. Opt.41(4), 805–812 (2002).
[CrossRef] [PubMed]

L. Vabre, A. Dubois, and A. C. Boccara, “Thermal-light full-field optical coherence tomography,” Opt. Lett.27(7), 530–532 (2002).
[CrossRef] [PubMed]

Ford, T.

French, P. M.

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

French, P. M. W.

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

Gigan, S.

J. Ben Arous, J. Binding, J. F. Léger, M. Casado, P. Topilko, S. Gigan, A. C. Boccara, and L. Bourdieu, “Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy,” J. Biomed. Opt.16(11), 116012 (2011).
[CrossRef] [PubMed]

Grieve, K.

A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, “Ultrahigh-resolution full-field optical coherence tomography,” Appl. Opt.43(14), 2874–2883 (2004).
[CrossRef] [PubMed]

A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, “Three-dimensional cellular-level imaging using full-field optical coherence tomography,” Phys. Med. Biol.49(7), 1227–1234 (2004).
[CrossRef] [PubMed]

J. F. Le Gargasson, K. Grieve, M. Paques, A. Dubois, and C. Boccara, “Imaging of ocular tissues using ultrahigh resolution full-field optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45, E-Abstract 2784 (2004).

Gu, Y.

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

Guerin, K. I.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

K. M. Connor, N. M. Krah, R. J. Dennison, C. M. Aderman, J. Chen, K. I. Guerin, P. Sapieha, A. Stahl, K. L. Willett, and L. E. Smith, “Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis,” Nat. Protoc.4(11), 1565–1573 (2009).
[CrossRef] [PubMed]

Hellström, A.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

Hua, J.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

Iftimia, N.

Jaffer, F. A.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Jain, M.

M. Jain, N. Shukla, M. Manzoor, S. Nadolny, and S. Mukherjee, “Modified full-field optical coherence tomography: A novel tool for rapid histology of tissues,” J Pathol Inform2(1), 28 (2011).
[CrossRef] [PubMed]

Jones, R.

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

Juškaitis, R.

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

D. Karadaglić, R. Juškaitis, and T. Wilson, “Confocal endoscopy via structured illumination,” Scanning24(6), 301–304 (2002).
[CrossRef] [PubMed]

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

M. A. Neil, A. Squire, R. Juškaitis, P. I. Bastiaens, and T. Wilson, “Wide-field optically sectioning fluorescence microscopy with laser illumination,” J. Microsc.197(1), 1–4 (2000).
[CrossRef] [PubMed]

M. A. Neil, R. Juškaitis, and T. Wilson, “Method of obtaining optical sectioning by using structured light in a conventional microscope,” Opt. Lett.22(24), 1905–1907 (1997).
[CrossRef] [PubMed]

Karadaglic, D.

D. Karadaglić and T. Wilson, “Image formation in structured illumination wide-field fluorescence microscopy,” Micron39(7), 808–818 (2008).
[CrossRef] [PubMed]

D. Karadaglić, R. Juškaitis, and T. Wilson, “Confocal endoscopy via structured illumination,” Scanning24(6), 301–304 (2002).
[CrossRef] [PubMed]

Kim, J. W.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Krah, N. M.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

K. M. Connor, N. M. Krah, R. J. Dennison, C. M. Aderman, J. Chen, K. I. Guerin, P. Sapieha, A. Stahl, K. L. Willett, and L. E. Smith, “Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis,” Nat. Protoc.4(11), 1565–1573 (2009).
[CrossRef] [PubMed]

Latrive, A.

Le Gargasson, J. F.

J. F. Le Gargasson, K. Grieve, M. Paques, A. Dubois, and C. Boccara, “Imaging of ocular tissues using ultrahigh resolution full-field optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45, E-Abstract 2784 (2004).

Lebec, M.

Lecaque, R.

Léger, J. F.

J. Ben Arous, J. Binding, J. F. Léger, M. Casado, P. Topilko, S. Gigan, A. C. Boccara, and L. Bourdieu, “Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy,” J. Biomed. Opt.16(11), 116012 (2011).
[CrossRef] [PubMed]

Leveque-Fort, S.

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

Lever, M. J.

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

Löfqvist, C.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

Manzoor, M.

M. Jain, N. Shukla, M. Manzoor, S. Nadolny, and S. Mukherjee, “Modified full-field optical coherence tomography: A novel tool for rapid histology of tissues,” J Pathol Inform2(1), 28 (2011).
[CrossRef] [PubMed]

McCarthy, J. R.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Mertz, J.

Moneron, G.

A. Dubois, G. Moneron, and C. Boccara, “Thermal-light full-field optical coherence tomography in the 1.2 µm wavelength region,” Opt. Commun.266(2), 738–743 (2006).
[CrossRef]

A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, “Three-dimensional cellular-level imaging using full-field optical coherence tomography,” Phys. Med. Biol.49(7), 1227–1234 (2004).
[CrossRef] [PubMed]

A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, “Ultrahigh-resolution full-field optical coherence tomography,” Appl. Opt.43(14), 2874–2883 (2004).
[CrossRef] [PubMed]

Moreaux, L.

Morse, T.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Mukherjee, S.

M. Jain, N. Shukla, M. Manzoor, S. Nadolny, and S. Mukherjee, “Modified full-field optical coherence tomography: A novel tool for rapid histology of tissues,” J Pathol Inform2(1), 28 (2011).
[CrossRef] [PubMed]

Nadolny, S.

M. Jain, N. Shukla, M. Manzoor, S. Nadolny, and S. Mukherjee, “Modified full-field optical coherence tomography: A novel tool for rapid histology of tissues,” J Pathol Inform2(1), 28 (2011).
[CrossRef] [PubMed]

Namati, E.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Neil, M. A.

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

M. A. Neil, A. Squire, R. Juškaitis, P. I. Bastiaens, and T. Wilson, “Wide-field optically sectioning fluorescence microscopy with laser illumination,” J. Microsc.197(1), 1–4 (2000).
[CrossRef] [PubMed]

M. A. Neil, R. Juškaitis, and T. Wilson, “Method of obtaining optical sectioning by using structured light in a conventional microscope,” Opt. Lett.22(24), 1905–1907 (1997).
[CrossRef] [PubMed]

Neil, M. A. A.

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

Ntziachristos, V.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Oh, W. Y.

Paques, M.

J. F. Le Gargasson, K. Grieve, M. Paques, A. Dubois, and C. Boccara, “Imaging of ocular tissues using ultrahigh resolution full-field optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45, E-Abstract 2784 (2004).

Parsons-Karavassilis, D.

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

Saint-Jalmes, H.

Sapieha, P.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

K. M. Connor, N. M. Krah, R. J. Dennison, C. M. Aderman, J. Chen, K. I. Guerin, P. Sapieha, A. Stahl, K. L. Willett, and L. E. Smith, “Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis,” Nat. Protoc.4(11), 1565–1573 (2009).
[CrossRef] [PubMed]

Seaward, M. R.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

Shishkov, M.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Shubochkin, R.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Shukla, N.

M. Jain, N. Shukla, M. Manzoor, S. Nadolny, and S. Mukherjee, “Modified full-field optical coherence tomography: A novel tool for rapid histology of tissues,” J Pathol Inform2(1), 28 (2011).
[CrossRef] [PubMed]

Siegel, J.

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

Smith, L. E.

K. M. Connor, N. M. Krah, R. J. Dennison, C. M. Aderman, J. Chen, K. I. Guerin, P. Sapieha, A. Stahl, K. L. Willett, and L. E. Smith, “Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis,” Nat. Protoc.4(11), 1565–1573 (2009).
[CrossRef] [PubMed]

Smith, L. E. H.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

Squire, A.

M. A. Neil, A. Squire, R. Juškaitis, P. I. Bastiaens, and T. Wilson, “Wide-field optically sectioning fluorescence microscopy with laser illumination,” J. Microsc.197(1), 1–4 (2000).
[CrossRef] [PubMed]

Stahl, A.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

K. M. Connor, N. M. Krah, R. J. Dennison, C. M. Aderman, J. Chen, K. I. Guerin, P. Sapieha, A. Stahl, K. L. Willett, and L. E. Smith, “Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis,” Nat. Protoc.4(11), 1565–1573 (2009).
[CrossRef] [PubMed]

Sucharov, L. O.

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

Sucharov, L. O. D.

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

Tearney, G. J.

Topilko, P.

J. Ben Arous, J. Binding, J. F. Léger, M. Casado, P. Topilko, S. Gigan, A. C. Boccara, and L. Bourdieu, “Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy,” J. Biomed. Opt.16(11), 116012 (2011).
[CrossRef] [PubMed]

Vabre, L.

Ventalon, C.

Webb, S. E.

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

Webb, S. E. D.

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

Willett, K. L.

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

K. M. Connor, N. M. Krah, R. J. Dennison, C. M. Aderman, J. Chen, K. I. Guerin, P. Sapieha, A. Stahl, K. L. Willett, and L. E. Smith, “Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis,” Nat. Protoc.4(11), 1565–1573 (2009).
[CrossRef] [PubMed]

Wilson, T.

D. Karadaglić and T. Wilson, “Image formation in structured illumination wide-field fluorescence microscopy,” Micron39(7), 808–818 (2008).
[CrossRef] [PubMed]

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

D. Karadaglić, R. Juškaitis, and T. Wilson, “Confocal endoscopy via structured illumination,” Scanning24(6), 301–304 (2002).
[CrossRef] [PubMed]

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

M. A. Neil, A. Squire, R. Juškaitis, P. I. Bastiaens, and T. Wilson, “Wide-field optically sectioning fluorescence microscopy with laser illumination,” J. Microsc.197(1), 1–4 (2000).
[CrossRef] [PubMed]

M. A. Neil, R. Juškaitis, and T. Wilson, “Method of obtaining optical sectioning by using structured light in a conventional microscope,” Opt. Lett.22(24), 1905–1907 (1997).
[CrossRef] [PubMed]

Yelin, R.

Yoo, H.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Yun, S. H.

Appl. Opt. (2)

Biomed. Opt. Express (1)

Invest. Ophthalmol. Vis. Sci. (2)

J. F. Le Gargasson, K. Grieve, M. Paques, A. Dubois, and C. Boccara, “Imaging of ocular tissues using ultrahigh resolution full-field optical coherence tomography,” Invest. Ophthalmol. Vis. Sci.45, E-Abstract 2784 (2004).

A. Stahl, K. M. Connor, P. Sapieha, J. Chen, R. J. Dennison, N. M. Krah, M. R. Seaward, K. L. Willett, C. M. Aderman, K. I. Guerin, J. Hua, C. Löfqvist, A. Hellström, and L. E. H. Smith, “The mouse retina as an angiogenesis model,” Invest. Ophthalmol. Vis. Sci.51(6), 2813–2826 (2010).
[CrossRef] [PubMed]

J Pathol Inform (1)

M. Jain, N. Shukla, M. Manzoor, S. Nadolny, and S. Mukherjee, “Modified full-field optical coherence tomography: A novel tool for rapid histology of tissues,” J Pathol Inform2(1), 28 (2011).
[CrossRef] [PubMed]

J. Biomed. Opt. (1)

J. Ben Arous, J. Binding, J. F. Léger, M. Casado, P. Topilko, S. Gigan, A. C. Boccara, and L. Bourdieu, “Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy,” J. Biomed. Opt.16(11), 116012 (2011).
[CrossRef] [PubMed]

J. Microsc. (2)

M. J. Cole, J. Siegel, S. E. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. French, M. J. Lever, L. O. Sucharov, M. A. Neil, R. Juškaitis, and T. Wilson, “Time-domain whole-field fluorescence lifetime imaging with optical sectioning,” J. Microsc.203(3), 246–257 (2001).
[CrossRef] [PubMed]

M. A. Neil, A. Squire, R. Juškaitis, P. I. Bastiaens, and T. Wilson, “Wide-field optically sectioning fluorescence microscopy with laser illumination,” J. Microsc.197(1), 1–4 (2000).
[CrossRef] [PubMed]

Micron (1)

D. Karadaglić and T. Wilson, “Image formation in structured illumination wide-field fluorescence microscopy,” Micron39(7), 808–818 (2008).
[CrossRef] [PubMed]

Nat. Med. (1)

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Nat. Protoc. (1)

K. M. Connor, N. M. Krah, R. J. Dennison, C. M. Aderman, J. Chen, K. I. Guerin, P. Sapieha, A. Stahl, K. L. Willett, and L. E. Smith, “Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis,” Nat. Protoc.4(11), 1565–1573 (2009).
[CrossRef] [PubMed]

Opt. Commun. (1)

A. Dubois, G. Moneron, and C. Boccara, “Thermal-light full-field optical coherence tomography in the 1.2 µm wavelength region,” Opt. Commun.266(2), 738–743 (2006).
[CrossRef]

Opt. Express (3)

Opt. Lett. (4)

Phys. Med. Biol. (1)

A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, “Three-dimensional cellular-level imaging using full-field optical coherence tomography,” Phys. Med. Biol.49(7), 1227–1234 (2004).
[CrossRef] [PubMed]

Rev. Sci. Instrum. (1)

S. E. D. Webb, Y. Gu, S. Leveque-Fort, J. Siegel, M. J. Cole, K. Dowling, R. Jones, P. M. W. French, M. A. A. Neil, R. Juškaitis, L. O. D. Sucharov, T. Wilson, and M. J. Lever, “A wide-field time-domain fluorescence lifetime imaging microscope with optical sectioning,” Rev. Sci. Instrum.73(4), 1898–1907 (2002).
[CrossRef]

Scanning (1)

D. Karadaglić, R. Juškaitis, and T. Wilson, “Confocal endoscopy via structured illumination,” Scanning24(6), 301–304 (2002).
[CrossRef] [PubMed]

Supplementary Material (2)

» Media 1: MOV (2998 KB)     
» Media 2: MOV (4851 KB)     

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Figures (5)

Fig. 1
Fig. 1

(a) A schematic diagram of dual imaging microscope. The filter and mirror are flipped-in to switch between FFOCM and fluorescence microscopy. A spatial intensity grid is added to implement structured illumination fluorescence microscopy technique. (b) Comparison of measured optical sectioning performance for FFOCM and fluorescence structured illumination microscopy.

Fig. 2
Fig. 2

x-z (axial) images of fixed and stained mouse retina as acquired with conventional wide-field fluorescence (a), structured illumination fluorescence (b) and full-field optical coherence (c) microscopy techniques. Images (a)&(b) were constructed as the maximum value pixel projection from 512 x-z sections of the reconstructed images. Capillary plexi: SCP –superficial capillary plexus; DCP—deep capillary plexus; Retinal layers: GCL—Ganglion cell layer; IPL—Inner plexiform layer; INL—Inner nuclear layer; OPL—Outer plexiform layer; ONL—Outer nuclear layer; Arrows indicate: BV—Blood vessel; GCB—Ganglion cell bodies.

Fig. 3
Fig. 3

x-y (lateral) images of fixed mouse retina with labeled endothelial cells as acquired with FFOCM (a) and structured illumination fluorescence microscopy (b) in ganglion cell layer. (c) Overlay of (a) and (b). GCB—Ganglion cell bodies; BV—blood vessels.

Fig. 4
Fig. 4

x-y overlay of FFOCM (gray) and fluorescence (yellow) images recorded in different fixed mouse retinal layers with labeled endothelial cells (Media 1).

Fig. 5
Fig. 5

3D cutaway view (Media 2) of the mouse retina acquired by the dual-modality microscope (gray—FFOCM signal, red-yellow—fluorescence signal).

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