Abstract

A multi-functional imaging system capable of determining relative changes in blood flow, hemoglobin concentration, and morphological features of the blood vasculature is demonstrated. The system combines two non-invasive imaging techniques, a dual-wavelength laser speckle contrast imaging (2-LSI) and an optical microangiography (OMAG) system. 2-LSI is used to monitor the changes in the dynamic blood flow and the changes in the concentration of oxygenated (HbO), deoxygenated (Hb) and total hemoglobin (HbT). The OMAG system is used to acquire high resolution images of the functional blood vessel network. The vessel area density (VAD) is used to quantify the blood vessel network morphology, specifically the capillary recruitment. The proposed multi-functional system is employed to assess the blood perfusion status from a mouse pinna before and immediately after a burn injury. To our knowledge, this is the first non-invasive, non-contact and multifunctional imaging modality that can simultaneously measure variations of several blood perfusion parameters.

© 2012 OSA

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. L. Pascarella, G. W. Schmid Schönbein, and J. J. Bergan, “Microcirculation and venous ulcers: a review,” Ann. Vasc. Surg. 19(6), 921–927 (2005).
    [Crossref] [PubMed]
  2. D. L. Crandall, G. J. Hausman, and J. G. Kral, “A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives,” Microcirculation 4(2), 211–232 (1997).
    [Crossref] [PubMed]
  3. D. De Backer, J. Creteur, J. C. Preiser, M. J. Dubois, and J. L. Vincent, “Microvascular blood flow is altered in patients with sepsis,” Am. J. Respir. Crit. Care Med. 166(1), 98–104 (2002).
    [Crossref] [PubMed]
  4. S. C. Bondy, R. A. W. Lehman, and J. L. Purdy, “Visual attention affects brain blood flow,” Nature 248(5447), 440–441 (1974).
    [Crossref] [PubMed]
  5. G. Bell and A. M. Harper, “Measurement of regional blood flow through skin from clearance of krypton-85,” Nature 202(4933), 704–705 (1964).
    [Crossref] [PubMed]
  6. D. Attwell, A. M. Buchan, S. Charpak, M. Lauritzen, B. A. Macvicar, and E. A. Newman, “Glial and neuronal control of brain blood flow,” Nature 468(7321), 232–243 (2010).
    [Crossref] [PubMed]
  7. M. Ferrari, T. Binzoni, and V. Quaresima, “Oxidative metabolism in muscle,” Philos. Trans. R. Soc. Lond. B Biol. Sci. 352(1354), 677–683 (1997).
    [Crossref] [PubMed]
  8. V. Provitera, M. Nolano, N. Pappone, E. Lubrano, A. Stancanelli, B. Lanzillo, and L. Santoro, “Axonal degeneration in systemic sclerosis can be reverted by factors improving tissue oxygenation,” Rheumatology (Oxford) 46(11), 1739–1741 (2007).
    [Crossref] [PubMed]
  9. S. R. Nirmala, S. Dandapat, and P. M. Bora, “Wavelet weighted blood vessel distortion measure for retinal images,” Biomed. Signal Process. Control 5(4), 282–291 (2010).
    [Crossref]
  10. G. Ciuffetti, L. Pasqualini, M. Pirro, R. Lombardini, M. De Sio, G. Schillaci, and E. Mannarino, “Blood rheology in men with essential hypertension and capillary rarefaction,” J. Hum. Hypertens. 16(8), 533–537 (2002).
    [Crossref] [PubMed]
  11. P. M. Hutchins, V. L. Roddick, and J. W. Dusseau, “Correlation of blood-pressure and rarefaction of small arterioles in back-crossed spontaneously hypertensive rats,” Microvasc. Res. 21, 246–9999 (1981).
  12. J. P. Noon, B. R. Walker, D. J. Webb, A. C. Shore, D. W. Holton, H. V. Edwards, and G. C. M. Watt, “Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure,” J. Clin. Invest. 99(8), 1873–1879 (1997).
    [Crossref] [PubMed]
  13. C. M. Wacker, A. W. Hartlep, M. Bock, S. Pfleger, G. Beck, G. van Kaick, L. R. Schad, and W. R. Bauer, “BOLD-MRI of the heart in patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery,” Circulation 98, 371–9999 (1998).
  14. F. S. Sutherland, E. Stefansson, D. L. Hatchell, and H. Reiser, “Retinal oxygen consumption in vitro. The effect of diabetes mellitus, oxygen and glucose,” Acta Ophthalmol. (Copenh.) 68(6), 715–720 (1990).
    [Crossref] [PubMed]
  15. W. W. Wagner, L. P. Latham, and R. L. Capen, “Capillary recruitment during airway hypoxia: role of pulmonary artery pressure,” J. Appl. Physiol. 47(2), 383–387 (1979).
    [PubMed]
  16. P. Horstmann, “The oxygen consumption in diabetes mellitus,” Acta Med. Scand. 139(4), 326–330 (1951).
    [Crossref] [PubMed]
  17. E. Tibiriçá, E. Rodrigues, R. A. Cobas, and M. B. Gomes, “Endothelial function in patients with type 1 diabetes evaluated by skin capillary recruitment,” Microvasc. Res. 73(2), 107–112 (2007).
    [Crossref] [PubMed]
  18. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
    [Crossref] [PubMed]
  19. S. A. Boppart, B. E. Bouma, C. Pitris, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “In vivo cellular optical coherence tomography imaging,” Nat. Med. 4(7), 861–865 (1998).
    [Crossref] [PubMed]
  20. L. An and R. K. Wang, “Use of a scanner to modulate spatial interferograms for in vivo full-range Fourier-domain optical coherence tomography,” Opt. Lett. 32(23), 3423–3425 (2007).
    [Crossref] [PubMed]
  21. R. K. K. Wang and L. An, “Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence tomography at 92-kHz line scan rate,” J. Biomed. Opt. 16(5), 050503 (2011).
    [Crossref] [PubMed]
  22. H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
    [Crossref] [PubMed]
  23. J. A. Eyre, T. J. H. Essex, P. A. Flecknell, P. H. Bartholomew, and J. I. Sinclair, “A comparison of measurements of cerebral blood flow in the rabbit using laser Doppler spectroscopy and radionuclide labelled microspheres,” Clin. Phys. Physiol. Meas. 9(1), 65–74 (1988).
    [Crossref] [PubMed]
  24. D. A. Boas and A. K. Dunn, “Laser speckle contrast imaging in biomedical optics,” J. Biomed. Opt. 15(1), 011109 (2010).
    [Crossref] [PubMed]
  25. C. Ayata, A. K. Dunn, Y. Gursoy-OZdemir, Z. H. Huang, D. A. Boas, and M. A. Moskowitz, “Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex,” J. Cereb. Blood Flow Metab. 24(7), 744–755 (2004).
    [Crossref] [PubMed]
  26. A. F. Fercher and J. D. Briers, “Flow Visualization by Means of Single-Exposure Speckle Photography,” Opt. Commun. 37(5), 326–330 (1981).
    [Crossref]
  27. J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray, C. Richardson, and E. O. R. Reynolds, “Responses of cerebral vasculature to changes in arterial carbon-dioxide tension measured by near-infrared spectroscopy in newborn-infants,” Pediatr. Res. 22(2), 230–9999 (1987).
    [Crossref]
  28. Z. Luo, Z. Yuan, Y. Pan, and C. Du, “Simultaneous imaging of cortical hemodynamics and blood oxygenation change during cerebral ischemia using dual-wavelength laser speckle contrast imaging,” Opt. Lett. 34(9), 1480–1482 (2009).
    [Crossref] [PubMed]
  29. A. K. Dunn, A. Devor, H. Bolay, M. L. Andermann, M. A. Moskowitz, A. M. Dale, and D. A. Boas, “Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation,” Opt. Lett. 28(1), 28–30 (2003).
    [Crossref] [PubMed]
  30. B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
    [Crossref] [PubMed]
  31. L. An, J. Qin, and R. K. Wang, “Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds,” Opt. Express 18(8), 8220–8228 (2010).
    [Crossref] [PubMed]
  32. M. Jones, J. Berwick, D. Johnston, and J. Mayhew, “Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex,” Neuroimage 13(6), 1002–1015 (2001).
    [Crossref] [PubMed]
  33. R. K. Wang, “Three-dimensional optical micro-angiography maps directional blood perfusion deep within microcirculation tissue beds in vivo,” Phys. Med. Biol. 52(23), N531–N537 (2007).
    [Crossref] [PubMed]
  34. R. K. K. Wang and Z. H. Ma, “Real-time flow imaging by removing texture pattern artifacts in spectral-domain optical Doppler tomography,” Opt. Lett. 31(20), 3001–3003 (2006).
    [Crossref] [PubMed]
  35. M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express 12(11), 2404–2422 (2004).
    [Crossref] [PubMed]
  36. A. C. Sull, L. N. Vuong, L. L. Price, V. J. Srinivasan, I. Gorczynska, J. G. Fujimoto, J. S. Schuman, and J. S. Duker, “Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retina 30(2), 235–245 (2010).
    [Crossref] [PubMed]
  37. A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of Intraocular Distances by Backscattering Spectral Interferometry,” Opt. Commun. 117(1-2), 43–48 (1995).
    [Crossref]
  38. L. An and R. K. Wang, “Full range complex ultrahigh sensitive optical microangiography,” Opt. Lett. 36(6), 831–833 (2011).
    [Crossref] [PubMed]
  39. H. M. Subhash, V. Davila, H. Sun, A. T. Nguyen-Huynh, X. R. Shi, A. L. Nuttall, and R. K. K. Wang, “Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography,” IEEE Trans. Med. Imaging 30(2), 224–230 (2011).
    [Crossref] [PubMed]
  40. J. Qin, J. Y. Jiang, L. An, D. Gareau, and R. K. Wang, “In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography,” Lasers Surg. Med. 43(2), 122–129 (2011).
    [Crossref] [PubMed]
  41. L. An and R. K. K. Wang, “In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography,” Opt. Express 16(15), 11438–11452 (2008).
    [Crossref] [PubMed]
  42. Y. L. Jia, J. Qin, Z. W. Zhi, and R. K. K. Wang, “Ultrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice,” J. Biomed. Opt. 16(8), 086004 (2011).
    [Crossref] [PubMed]
  43. S. Wray, M. Cope, D. T. Delpy, J. S. Wyatt, and E. O. R. Reynolds, “Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation,” Biochim. Biophys. Acta 933(1), 184–192 (1988).
    [Crossref] [PubMed]
  44. S. J. Kirkpatrick, D. D. Duncan, and E. M. Wells-Gray, “Detrimental effects of speckle-pixel size matching in laser speckle contrast imaging,” Opt. Lett. 33(24), 2886–2888 (2008).
    [Crossref] [PubMed]
  45. A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21(3), 195–201 (2001).
    [Crossref] [PubMed]
  46. C. W. Du, A. P. Koretsky, I. Izrailtyan, and H. Benveniste, “Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using diffuse reflectance and fluorescence,” J. Cereb. Blood Flow Metab. 25(8), 1078–1092 (2005).
    [Crossref] [PubMed]
  47. T. Kusaka, Y. Hisamatsu, K. Kawada, K. Okubo, H. Okada, M. Namba, T. Imai, K. Isobe, and S. Itoh, “Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia,” Opt. Rev. 10(5), 466–469 (2003).
    [Crossref]
  48. M. E. Seaman, S. M. Peirce, and K. Kelly, “Rapid analysis of vessel elements (RAVE): a tool for studying physiologic, pathologic and tumor angiogenesis,” PLoS ONE 6(6), e20807 (2011).
    [Crossref] [PubMed]
  49. H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Imaging acute thermal burns by photoacoustic microscopy,” J. Biomed. Opt. 11(5), 054033 (2006).
    [Crossref] [PubMed]
  50. H. Schulte, A. Sollevi, and M. Segerdahl, “The distribution of hyperaemia induced by skin burn injury is not correlated with the development of secondary punctate hyperalgesia,” J. Pain 5(4), 212–217 (2004).
    [Crossref] [PubMed]
  51. D. G. Crawford, H. M. Fairchild, and A. C. Guyton, “Oxygen lack as a possible cause of reactive hyperemia,” Am. J. Physiol. 197, 613–616 (1959).
    [PubMed]
  52. J. Schrader, F. J. Haddy, and E. Gerlach, “Release of adenosine, inosine and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregulation and reactive hyperemia,” Pflugers Arch. 369(1), 1–6 (1977).
    [Crossref] [PubMed]
  53. C. Mayeur, S. Campard, C. Richard, and J. L. Teboul, “Comparison of four different vascular occlusion tests for assessing reactive hyperemia using near-infrared spectroscopy,” Crit. Care Med. 39(4), 695–701 (2011).
    [Crossref] [PubMed]
  54. S. Trojan and J. Kapitola, “Reaktivní hyperémie mozku potkana po výskové hypoxii [Reactive hyperemia in the brain of rats after high altitude hypoxia],” Sb. Lek. 92(4), 97–102 (1990).
    [PubMed]
  55. A. H. Mulder, A. P. J. van Dijk, P. Smits, and C. J. Tack, “Real-time contrast imaging: a new method to monitor capillary recruitment in human forearm skeletal muscle,” Microcirculation 15(3), 203–213 (2008).
    [Crossref] [PubMed]
  56. K. Parthasarathi and H. H. Lipowsky, “Capillary recruitment in response to tissue hypoxia and its dependence on red blood cell deformability,” Am. J. Physiol. 277(6 Pt 2), H2145–H2157 (1999).
    [PubMed]

2011 (7)

R. K. K. Wang and L. An, “Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence tomography at 92-kHz line scan rate,” J. Biomed. Opt. 16(5), 050503 (2011).
[Crossref] [PubMed]

M. E. Seaman, S. M. Peirce, and K. Kelly, “Rapid analysis of vessel elements (RAVE): a tool for studying physiologic, pathologic and tumor angiogenesis,” PLoS ONE 6(6), e20807 (2011).
[Crossref] [PubMed]

C. Mayeur, S. Campard, C. Richard, and J. L. Teboul, “Comparison of four different vascular occlusion tests for assessing reactive hyperemia using near-infrared spectroscopy,” Crit. Care Med. 39(4), 695–701 (2011).
[Crossref] [PubMed]

H. M. Subhash, V. Davila, H. Sun, A. T. Nguyen-Huynh, X. R. Shi, A. L. Nuttall, and R. K. K. Wang, “Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography,” IEEE Trans. Med. Imaging 30(2), 224–230 (2011).
[Crossref] [PubMed]

J. Qin, J. Y. Jiang, L. An, D. Gareau, and R. K. Wang, “In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography,” Lasers Surg. Med. 43(2), 122–129 (2011).
[Crossref] [PubMed]

Y. L. Jia, J. Qin, Z. W. Zhi, and R. K. K. Wang, “Ultrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice,” J. Biomed. Opt. 16(8), 086004 (2011).
[Crossref] [PubMed]

L. An and R. K. Wang, “Full range complex ultrahigh sensitive optical microangiography,” Opt. Lett. 36(6), 831–833 (2011).
[Crossref] [PubMed]

2010 (5)

L. An, J. Qin, and R. K. Wang, “Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds,” Opt. Express 18(8), 8220–8228 (2010).
[Crossref] [PubMed]

A. C. Sull, L. N. Vuong, L. L. Price, V. J. Srinivasan, I. Gorczynska, J. G. Fujimoto, J. S. Schuman, and J. S. Duker, “Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retina 30(2), 235–245 (2010).
[Crossref] [PubMed]

D. A. Boas and A. K. Dunn, “Laser speckle contrast imaging in biomedical optics,” J. Biomed. Opt. 15(1), 011109 (2010).
[Crossref] [PubMed]

D. Attwell, A. M. Buchan, S. Charpak, M. Lauritzen, B. A. Macvicar, and E. A. Newman, “Glial and neuronal control of brain blood flow,” Nature 468(7321), 232–243 (2010).
[Crossref] [PubMed]

S. R. Nirmala, S. Dandapat, and P. M. Bora, “Wavelet weighted blood vessel distortion measure for retinal images,” Biomed. Signal Process. Control 5(4), 282–291 (2010).
[Crossref]

2009 (2)

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

Z. Luo, Z. Yuan, Y. Pan, and C. Du, “Simultaneous imaging of cortical hemodynamics and blood oxygenation change during cerebral ischemia using dual-wavelength laser speckle contrast imaging,” Opt. Lett. 34(9), 1480–1482 (2009).
[Crossref] [PubMed]

2008 (3)

2007 (4)

L. An and R. K. Wang, “Use of a scanner to modulate spatial interferograms for in vivo full-range Fourier-domain optical coherence tomography,” Opt. Lett. 32(23), 3423–3425 (2007).
[Crossref] [PubMed]

R. K. Wang, “Three-dimensional optical micro-angiography maps directional blood perfusion deep within microcirculation tissue beds in vivo,” Phys. Med. Biol. 52(23), N531–N537 (2007).
[Crossref] [PubMed]

V. Provitera, M. Nolano, N. Pappone, E. Lubrano, A. Stancanelli, B. Lanzillo, and L. Santoro, “Axonal degeneration in systemic sclerosis can be reverted by factors improving tissue oxygenation,” Rheumatology (Oxford) 46(11), 1739–1741 (2007).
[Crossref] [PubMed]

E. Tibiriçá, E. Rodrigues, R. A. Cobas, and M. B. Gomes, “Endothelial function in patients with type 1 diabetes evaluated by skin capillary recruitment,” Microvasc. Res. 73(2), 107–112 (2007).
[Crossref] [PubMed]

2006 (3)

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Imaging acute thermal burns by photoacoustic microscopy,” J. Biomed. Opt. 11(5), 054033 (2006).
[Crossref] [PubMed]

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref] [PubMed]

R. K. K. Wang and Z. H. Ma, “Real-time flow imaging by removing texture pattern artifacts in spectral-domain optical Doppler tomography,” Opt. Lett. 31(20), 3001–3003 (2006).
[Crossref] [PubMed]

2005 (2)

C. W. Du, A. P. Koretsky, I. Izrailtyan, and H. Benveniste, “Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using diffuse reflectance and fluorescence,” J. Cereb. Blood Flow Metab. 25(8), 1078–1092 (2005).
[Crossref] [PubMed]

L. Pascarella, G. W. Schmid Schönbein, and J. J. Bergan, “Microcirculation and venous ulcers: a review,” Ann. Vasc. Surg. 19(6), 921–927 (2005).
[Crossref] [PubMed]

2004 (3)

C. Ayata, A. K. Dunn, Y. Gursoy-OZdemir, Z. H. Huang, D. A. Boas, and M. A. Moskowitz, “Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex,” J. Cereb. Blood Flow Metab. 24(7), 744–755 (2004).
[Crossref] [PubMed]

H. Schulte, A. Sollevi, and M. Segerdahl, “The distribution of hyperaemia induced by skin burn injury is not correlated with the development of secondary punctate hyperalgesia,” J. Pain 5(4), 212–217 (2004).
[Crossref] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express 12(11), 2404–2422 (2004).
[Crossref] [PubMed]

2003 (2)

A. K. Dunn, A. Devor, H. Bolay, M. L. Andermann, M. A. Moskowitz, A. M. Dale, and D. A. Boas, “Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation,” Opt. Lett. 28(1), 28–30 (2003).
[Crossref] [PubMed]

T. Kusaka, Y. Hisamatsu, K. Kawada, K. Okubo, H. Okada, M. Namba, T. Imai, K. Isobe, and S. Itoh, “Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia,” Opt. Rev. 10(5), 466–469 (2003).
[Crossref]

2002 (2)

D. De Backer, J. Creteur, J. C. Preiser, M. J. Dubois, and J. L. Vincent, “Microvascular blood flow is altered in patients with sepsis,” Am. J. Respir. Crit. Care Med. 166(1), 98–104 (2002).
[Crossref] [PubMed]

G. Ciuffetti, L. Pasqualini, M. Pirro, R. Lombardini, M. De Sio, G. Schillaci, and E. Mannarino, “Blood rheology in men with essential hypertension and capillary rarefaction,” J. Hum. Hypertens. 16(8), 533–537 (2002).
[Crossref] [PubMed]

2001 (2)

A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21(3), 195–201 (2001).
[Crossref] [PubMed]

M. Jones, J. Berwick, D. Johnston, and J. Mayhew, “Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex,” Neuroimage 13(6), 1002–1015 (2001).
[Crossref] [PubMed]

1999 (1)

K. Parthasarathi and H. H. Lipowsky, “Capillary recruitment in response to tissue hypoxia and its dependence on red blood cell deformability,” Am. J. Physiol. 277(6 Pt 2), H2145–H2157 (1999).
[PubMed]

1998 (2)

S. A. Boppart, B. E. Bouma, C. Pitris, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “In vivo cellular optical coherence tomography imaging,” Nat. Med. 4(7), 861–865 (1998).
[Crossref] [PubMed]

C. M. Wacker, A. W. Hartlep, M. Bock, S. Pfleger, G. Beck, G. van Kaick, L. R. Schad, and W. R. Bauer, “BOLD-MRI of the heart in patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery,” Circulation 98, 371–9999 (1998).

1997 (3)

J. P. Noon, B. R. Walker, D. J. Webb, A. C. Shore, D. W. Holton, H. V. Edwards, and G. C. M. Watt, “Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure,” J. Clin. Invest. 99(8), 1873–1879 (1997).
[Crossref] [PubMed]

M. Ferrari, T. Binzoni, and V. Quaresima, “Oxidative metabolism in muscle,” Philos. Trans. R. Soc. Lond. B Biol. Sci. 352(1354), 677–683 (1997).
[Crossref] [PubMed]

D. L. Crandall, G. J. Hausman, and J. G. Kral, “A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives,” Microcirculation 4(2), 211–232 (1997).
[Crossref] [PubMed]

1995 (1)

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of Intraocular Distances by Backscattering Spectral Interferometry,” Opt. Commun. 117(1-2), 43–48 (1995).
[Crossref]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

1990 (2)

F. S. Sutherland, E. Stefansson, D. L. Hatchell, and H. Reiser, “Retinal oxygen consumption in vitro. The effect of diabetes mellitus, oxygen and glucose,” Acta Ophthalmol. (Copenh.) 68(6), 715–720 (1990).
[Crossref] [PubMed]

S. Trojan and J. Kapitola, “Reaktivní hyperémie mozku potkana po výskové hypoxii [Reactive hyperemia in the brain of rats after high altitude hypoxia],” Sb. Lek. 92(4), 97–102 (1990).
[PubMed]

1988 (2)

S. Wray, M. Cope, D. T. Delpy, J. S. Wyatt, and E. O. R. Reynolds, “Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation,” Biochim. Biophys. Acta 933(1), 184–192 (1988).
[Crossref] [PubMed]

J. A. Eyre, T. J. H. Essex, P. A. Flecknell, P. H. Bartholomew, and J. I. Sinclair, “A comparison of measurements of cerebral blood flow in the rabbit using laser Doppler spectroscopy and radionuclide labelled microspheres,” Clin. Phys. Physiol. Meas. 9(1), 65–74 (1988).
[Crossref] [PubMed]

1987 (1)

J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray, C. Richardson, and E. O. R. Reynolds, “Responses of cerebral vasculature to changes in arterial carbon-dioxide tension measured by near-infrared spectroscopy in newborn-infants,” Pediatr. Res. 22(2), 230–9999 (1987).
[Crossref]

1981 (2)

A. F. Fercher and J. D. Briers, “Flow Visualization by Means of Single-Exposure Speckle Photography,” Opt. Commun. 37(5), 326–330 (1981).
[Crossref]

P. M. Hutchins, V. L. Roddick, and J. W. Dusseau, “Correlation of blood-pressure and rarefaction of small arterioles in back-crossed spontaneously hypertensive rats,” Microvasc. Res. 21, 246–9999 (1981).

1979 (1)

W. W. Wagner, L. P. Latham, and R. L. Capen, “Capillary recruitment during airway hypoxia: role of pulmonary artery pressure,” J. Appl. Physiol. 47(2), 383–387 (1979).
[PubMed]

1977 (1)

J. Schrader, F. J. Haddy, and E. Gerlach, “Release of adenosine, inosine and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregulation and reactive hyperemia,” Pflugers Arch. 369(1), 1–6 (1977).
[Crossref] [PubMed]

1974 (1)

S. C. Bondy, R. A. W. Lehman, and J. L. Purdy, “Visual attention affects brain blood flow,” Nature 248(5447), 440–441 (1974).
[Crossref] [PubMed]

1964 (1)

G. Bell and A. M. Harper, “Measurement of regional blood flow through skin from clearance of krypton-85,” Nature 202(4933), 704–705 (1964).
[Crossref] [PubMed]

1959 (1)

D. G. Crawford, H. M. Fairchild, and A. C. Guyton, “Oxygen lack as a possible cause of reactive hyperemia,” Am. J. Physiol. 197, 613–616 (1959).
[PubMed]

1951 (1)

P. Horstmann, “The oxygen consumption in diabetes mellitus,” Acta Med. Scand. 139(4), 326–330 (1951).
[Crossref] [PubMed]

An, L.

Andermann, M. L.

Attwell, D.

D. Attwell, A. M. Buchan, S. Charpak, M. Lauritzen, B. A. Macvicar, and E. A. Newman, “Glial and neuronal control of brain blood flow,” Nature 468(7321), 232–243 (2010).
[Crossref] [PubMed]

Ayata, C.

C. Ayata, A. K. Dunn, Y. Gursoy-OZdemir, Z. H. Huang, D. A. Boas, and M. A. Moskowitz, “Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex,” J. Cereb. Blood Flow Metab. 24(7), 744–755 (2004).
[Crossref] [PubMed]

Bartholomew, P. H.

J. A. Eyre, T. J. H. Essex, P. A. Flecknell, P. H. Bartholomew, and J. I. Sinclair, “A comparison of measurements of cerebral blood flow in the rabbit using laser Doppler spectroscopy and radionuclide labelled microspheres,” Clin. Phys. Physiol. Meas. 9(1), 65–74 (1988).
[Crossref] [PubMed]

Bartlett, L. A.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

Bauer, W. R.

C. M. Wacker, A. W. Hartlep, M. Bock, S. Pfleger, G. Beck, G. van Kaick, L. R. Schad, and W. R. Bauer, “BOLD-MRI of the heart in patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery,” Circulation 98, 371–9999 (1998).

Beck, G.

C. M. Wacker, A. W. Hartlep, M. Bock, S. Pfleger, G. Beck, G. van Kaick, L. R. Schad, and W. R. Bauer, “BOLD-MRI of the heart in patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery,” Circulation 98, 371–9999 (1998).

Bell, G.

G. Bell and A. M. Harper, “Measurement of regional blood flow through skin from clearance of krypton-85,” Nature 202(4933), 704–705 (1964).
[Crossref] [PubMed]

Benveniste, H.

C. W. Du, A. P. Koretsky, I. Izrailtyan, and H. Benveniste, “Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using diffuse reflectance and fluorescence,” J. Cereb. Blood Flow Metab. 25(8), 1078–1092 (2005).
[Crossref] [PubMed]

Bergan, J. J.

L. Pascarella, G. W. Schmid Schönbein, and J. J. Bergan, “Microcirculation and venous ulcers: a review,” Ann. Vasc. Surg. 19(6), 921–927 (2005).
[Crossref] [PubMed]

Berwick, J.

M. Jones, J. Berwick, D. Johnston, and J. Mayhew, “Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex,” Neuroimage 13(6), 1002–1015 (2001).
[Crossref] [PubMed]

Binzoni, T.

M. Ferrari, T. Binzoni, and V. Quaresima, “Oxidative metabolism in muscle,” Philos. Trans. R. Soc. Lond. B Biol. Sci. 352(1354), 677–683 (1997).
[Crossref] [PubMed]

Boas, D. A.

D. A. Boas and A. K. Dunn, “Laser speckle contrast imaging in biomedical optics,” J. Biomed. Opt. 15(1), 011109 (2010).
[Crossref] [PubMed]

C. Ayata, A. K. Dunn, Y. Gursoy-OZdemir, Z. H. Huang, D. A. Boas, and M. A. Moskowitz, “Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex,” J. Cereb. Blood Flow Metab. 24(7), 744–755 (2004).
[Crossref] [PubMed]

A. K. Dunn, A. Devor, H. Bolay, M. L. Andermann, M. A. Moskowitz, A. M. Dale, and D. A. Boas, “Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation,” Opt. Lett. 28(1), 28–30 (2003).
[Crossref] [PubMed]

A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21(3), 195–201 (2001).
[Crossref] [PubMed]

Bock, M.

C. M. Wacker, A. W. Hartlep, M. Bock, S. Pfleger, G. Beck, G. van Kaick, L. R. Schad, and W. R. Bauer, “BOLD-MRI of the heart in patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery,” Circulation 98, 371–9999 (1998).

Bolay, H.

Bondy, S. C.

S. C. Bondy, R. A. W. Lehman, and J. L. Purdy, “Visual attention affects brain blood flow,” Nature 248(5447), 440–441 (1974).
[Crossref] [PubMed]

Boppart, S. A.

S. A. Boppart, B. E. Bouma, C. Pitris, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “In vivo cellular optical coherence tomography imaging,” Nat. Med. 4(7), 861–865 (1998).
[Crossref] [PubMed]

Bora, P. M.

S. R. Nirmala, S. Dandapat, and P. M. Bora, “Wavelet weighted blood vessel distortion measure for retinal images,” Biomed. Signal Process. Control 5(4), 282–291 (2010).
[Crossref]

Bouma, B. E.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

S. A. Boppart, B. E. Bouma, C. Pitris, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “In vivo cellular optical coherence tomography imaging,” Nat. Med. 4(7), 861–865 (1998).
[Crossref] [PubMed]

Brezinski, M. E.

S. A. Boppart, B. E. Bouma, C. Pitris, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “In vivo cellular optical coherence tomography imaging,” Nat. Med. 4(7), 861–865 (1998).
[Crossref] [PubMed]

Briers, J. D.

A. F. Fercher and J. D. Briers, “Flow Visualization by Means of Single-Exposure Speckle Photography,” Opt. Commun. 37(5), 326–330 (1981).
[Crossref]

Buchan, A. M.

D. Attwell, A. M. Buchan, S. Charpak, M. Lauritzen, B. A. Macvicar, and E. A. Newman, “Glial and neuronal control of brain blood flow,” Nature 468(7321), 232–243 (2010).
[Crossref] [PubMed]

Campard, S.

C. Mayeur, S. Campard, C. Richard, and J. L. Teboul, “Comparison of four different vascular occlusion tests for assessing reactive hyperemia using near-infrared spectroscopy,” Crit. Care Med. 39(4), 695–701 (2011).
[Crossref] [PubMed]

Capen, R. L.

W. W. Wagner, L. P. Latham, and R. L. Capen, “Capillary recruitment during airway hypoxia: role of pulmonary artery pressure,” J. Appl. Physiol. 47(2), 383–387 (1979).
[PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Charpak, S.

D. Attwell, A. M. Buchan, S. Charpak, M. Lauritzen, B. A. Macvicar, and E. A. Newman, “Glial and neuronal control of brain blood flow,” Nature 468(7321), 232–243 (2010).
[Crossref] [PubMed]

Ciuffetti, G.

G. Ciuffetti, L. Pasqualini, M. Pirro, R. Lombardini, M. De Sio, G. Schillaci, and E. Mannarino, “Blood rheology in men with essential hypertension and capillary rarefaction,” J. Hum. Hypertens. 16(8), 533–537 (2002).
[Crossref] [PubMed]

Cobas, R. A.

E. Tibiriçá, E. Rodrigues, R. A. Cobas, and M. B. Gomes, “Endothelial function in patients with type 1 diabetes evaluated by skin capillary recruitment,” Microvasc. Res. 73(2), 107–112 (2007).
[Crossref] [PubMed]

Cope, M.

S. Wray, M. Cope, D. T. Delpy, J. S. Wyatt, and E. O. R. Reynolds, “Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation,” Biochim. Biophys. Acta 933(1), 184–192 (1988).
[Crossref] [PubMed]

J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray, C. Richardson, and E. O. R. Reynolds, “Responses of cerebral vasculature to changes in arterial carbon-dioxide tension measured by near-infrared spectroscopy in newborn-infants,” Pediatr. Res. 22(2), 230–9999 (1987).
[Crossref]

Crandall, D. L.

D. L. Crandall, G. J. Hausman, and J. G. Kral, “A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives,” Microcirculation 4(2), 211–232 (1997).
[Crossref] [PubMed]

Crawford, D. G.

D. G. Crawford, H. M. Fairchild, and A. C. Guyton, “Oxygen lack as a possible cause of reactive hyperemia,” Am. J. Physiol. 197, 613–616 (1959).
[PubMed]

Creteur, J.

D. De Backer, J. Creteur, J. C. Preiser, M. J. Dubois, and J. L. Vincent, “Microvascular blood flow is altered in patients with sepsis,” Am. J. Respir. Crit. Care Med. 166(1), 98–104 (2002).
[Crossref] [PubMed]

Dale, A. M.

Dandapat, S.

S. R. Nirmala, S. Dandapat, and P. M. Bora, “Wavelet weighted blood vessel distortion measure for retinal images,” Biomed. Signal Process. Control 5(4), 282–291 (2010).
[Crossref]

Davila, V.

H. M. Subhash, V. Davila, H. Sun, A. T. Nguyen-Huynh, X. R. Shi, A. L. Nuttall, and R. K. K. Wang, “Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography,” IEEE Trans. Med. Imaging 30(2), 224–230 (2011).
[Crossref] [PubMed]

De Backer, D.

D. De Backer, J. Creteur, J. C. Preiser, M. J. Dubois, and J. L. Vincent, “Microvascular blood flow is altered in patients with sepsis,” Am. J. Respir. Crit. Care Med. 166(1), 98–104 (2002).
[Crossref] [PubMed]

De Sio, M.

G. Ciuffetti, L. Pasqualini, M. Pirro, R. Lombardini, M. De Sio, G. Schillaci, and E. Mannarino, “Blood rheology in men with essential hypertension and capillary rarefaction,” J. Hum. Hypertens. 16(8), 533–537 (2002).
[Crossref] [PubMed]

Delpy, D. T.

S. Wray, M. Cope, D. T. Delpy, J. S. Wyatt, and E. O. R. Reynolds, “Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation,” Biochim. Biophys. Acta 933(1), 184–192 (1988).
[Crossref] [PubMed]

J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray, C. Richardson, and E. O. R. Reynolds, “Responses of cerebral vasculature to changes in arterial carbon-dioxide tension measured by near-infrared spectroscopy in newborn-infants,” Pediatr. Res. 22(2), 230–9999 (1987).
[Crossref]

Devor, A.

Du, C.

Du, C. W.

C. W. Du, A. P. Koretsky, I. Izrailtyan, and H. Benveniste, “Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using diffuse reflectance and fluorescence,” J. Cereb. Blood Flow Metab. 25(8), 1078–1092 (2005).
[Crossref] [PubMed]

Dubois, M. J.

D. De Backer, J. Creteur, J. C. Preiser, M. J. Dubois, and J. L. Vincent, “Microvascular blood flow is altered in patients with sepsis,” Am. J. Respir. Crit. Care Med. 166(1), 98–104 (2002).
[Crossref] [PubMed]

Duker, J. S.

A. C. Sull, L. N. Vuong, L. L. Price, V. J. Srinivasan, I. Gorczynska, J. G. Fujimoto, J. S. Schuman, and J. S. Duker, “Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retina 30(2), 235–245 (2010).
[Crossref] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express 12(11), 2404–2422 (2004).
[Crossref] [PubMed]

Duncan, D. D.

Dunn, A. K.

D. A. Boas and A. K. Dunn, “Laser speckle contrast imaging in biomedical optics,” J. Biomed. Opt. 15(1), 011109 (2010).
[Crossref] [PubMed]

C. Ayata, A. K. Dunn, Y. Gursoy-OZdemir, Z. H. Huang, D. A. Boas, and M. A. Moskowitz, “Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex,” J. Cereb. Blood Flow Metab. 24(7), 744–755 (2004).
[Crossref] [PubMed]

A. K. Dunn, A. Devor, H. Bolay, M. L. Andermann, M. A. Moskowitz, A. M. Dale, and D. A. Boas, “Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation,” Opt. Lett. 28(1), 28–30 (2003).
[Crossref] [PubMed]

A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21(3), 195–201 (2001).
[Crossref] [PubMed]

Dusseau, J. W.

P. M. Hutchins, V. L. Roddick, and J. W. Dusseau, “Correlation of blood-pressure and rarefaction of small arterioles in back-crossed spontaneously hypertensive rats,” Microvasc. Res. 21, 246–9999 (1981).

Edwards, H. V.

J. P. Noon, B. R. Walker, D. J. Webb, A. C. Shore, D. W. Holton, H. V. Edwards, and G. C. M. Watt, “Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure,” J. Clin. Invest. 99(8), 1873–1879 (1997).
[Crossref] [PubMed]

Elzaiat, S. Y.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of Intraocular Distances by Backscattering Spectral Interferometry,” Opt. Commun. 117(1-2), 43–48 (1995).
[Crossref]

Essex, T. J. H.

J. A. Eyre, T. J. H. Essex, P. A. Flecknell, P. H. Bartholomew, and J. I. Sinclair, “A comparison of measurements of cerebral blood flow in the rabbit using laser Doppler spectroscopy and radionuclide labelled microspheres,” Clin. Phys. Physiol. Meas. 9(1), 65–74 (1988).
[Crossref] [PubMed]

Eyre, J. A.

J. A. Eyre, T. J. H. Essex, P. A. Flecknell, P. H. Bartholomew, and J. I. Sinclair, “A comparison of measurements of cerebral blood flow in the rabbit using laser Doppler spectroscopy and radionuclide labelled microspheres,” Clin. Phys. Physiol. Meas. 9(1), 65–74 (1988).
[Crossref] [PubMed]

Fairchild, H. M.

D. G. Crawford, H. M. Fairchild, and A. C. Guyton, “Oxygen lack as a possible cause of reactive hyperemia,” Am. J. Physiol. 197, 613–616 (1959).
[PubMed]

Fercher, A. F.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of Intraocular Distances by Backscattering Spectral Interferometry,” Opt. Commun. 117(1-2), 43–48 (1995).
[Crossref]

A. F. Fercher and J. D. Briers, “Flow Visualization by Means of Single-Exposure Speckle Photography,” Opt. Commun. 37(5), 326–330 (1981).
[Crossref]

Ferrari, M.

M. Ferrari, T. Binzoni, and V. Quaresima, “Oxidative metabolism in muscle,” Philos. Trans. R. Soc. Lond. B Biol. Sci. 352(1354), 677–683 (1997).
[Crossref] [PubMed]

Flecknell, P. A.

J. A. Eyre, T. J. H. Essex, P. A. Flecknell, P. H. Bartholomew, and J. I. Sinclair, “A comparison of measurements of cerebral blood flow in the rabbit using laser Doppler spectroscopy and radionuclide labelled microspheres,” Clin. Phys. Physiol. Meas. 9(1), 65–74 (1988).
[Crossref] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Fujimoto, J. G.

A. C. Sull, L. N. Vuong, L. L. Price, V. J. Srinivasan, I. Gorczynska, J. G. Fujimoto, J. S. Schuman, and J. S. Duker, “Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retina 30(2), 235–245 (2010).
[Crossref] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express 12(11), 2404–2422 (2004).
[Crossref] [PubMed]

S. A. Boppart, B. E. Bouma, C. Pitris, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “In vivo cellular optical coherence tomography imaging,” Nat. Med. 4(7), 861–865 (1998).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Fukumura, D.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

Gareau, D.

J. Qin, J. Y. Jiang, L. An, D. Gareau, and R. K. Wang, “In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography,” Lasers Surg. Med. 43(2), 122–129 (2011).
[Crossref] [PubMed]

Gerlach, E.

J. Schrader, F. J. Haddy, and E. Gerlach, “Release of adenosine, inosine and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregulation and reactive hyperemia,” Pflugers Arch. 369(1), 1–6 (1977).
[Crossref] [PubMed]

Gomes, M. B.

E. Tibiriçá, E. Rodrigues, R. A. Cobas, and M. B. Gomes, “Endothelial function in patients with type 1 diabetes evaluated by skin capillary recruitment,” Microvasc. Res. 73(2), 107–112 (2007).
[Crossref] [PubMed]

Gorczynska, I.

A. C. Sull, L. N. Vuong, L. L. Price, V. J. Srinivasan, I. Gorczynska, J. G. Fujimoto, J. S. Schuman, and J. S. Duker, “Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retina 30(2), 235–245 (2010).
[Crossref] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Gursoy-OZdemir, Y.

C. Ayata, A. K. Dunn, Y. Gursoy-OZdemir, Z. H. Huang, D. A. Boas, and M. A. Moskowitz, “Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex,” J. Cereb. Blood Flow Metab. 24(7), 744–755 (2004).
[Crossref] [PubMed]

Guyton, A. C.

D. G. Crawford, H. M. Fairchild, and A. C. Guyton, “Oxygen lack as a possible cause of reactive hyperemia,” Am. J. Physiol. 197, 613–616 (1959).
[PubMed]

Haddy, F. J.

J. Schrader, F. J. Haddy, and E. Gerlach, “Release of adenosine, inosine and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregulation and reactive hyperemia,” Pflugers Arch. 369(1), 1–6 (1977).
[Crossref] [PubMed]

Harper, A. M.

G. Bell and A. M. Harper, “Measurement of regional blood flow through skin from clearance of krypton-85,” Nature 202(4933), 704–705 (1964).
[Crossref] [PubMed]

Hartlep, A. W.

C. M. Wacker, A. W. Hartlep, M. Bock, S. Pfleger, G. Beck, G. van Kaick, L. R. Schad, and W. R. Bauer, “BOLD-MRI of the heart in patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery,” Circulation 98, 371–9999 (1998).

Hatchell, D. L.

F. S. Sutherland, E. Stefansson, D. L. Hatchell, and H. Reiser, “Retinal oxygen consumption in vitro. The effect of diabetes mellitus, oxygen and glucose,” Acta Ophthalmol. (Copenh.) 68(6), 715–720 (1990).
[Crossref] [PubMed]

Hausman, G. J.

D. L. Crandall, G. J. Hausman, and J. G. Kral, “A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives,” Microcirculation 4(2), 211–232 (1997).
[Crossref] [PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Hisamatsu, Y.

T. Kusaka, Y. Hisamatsu, K. Kawada, K. Okubo, H. Okada, M. Namba, T. Imai, K. Isobe, and S. Itoh, “Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia,” Opt. Rev. 10(5), 466–469 (2003).
[Crossref]

Hitzenberger, C. K.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of Intraocular Distances by Backscattering Spectral Interferometry,” Opt. Commun. 117(1-2), 43–48 (1995).
[Crossref]

Holton, D. W.

J. P. Noon, B. R. Walker, D. J. Webb, A. C. Shore, D. W. Holton, H. V. Edwards, and G. C. M. Watt, “Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure,” J. Clin. Invest. 99(8), 1873–1879 (1997).
[Crossref] [PubMed]

Horstmann, P.

P. Horstmann, “The oxygen consumption in diabetes mellitus,” Acta Med. Scand. 139(4), 326–330 (1951).
[Crossref] [PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Huang, Z. H.

C. Ayata, A. K. Dunn, Y. Gursoy-OZdemir, Z. H. Huang, D. A. Boas, and M. A. Moskowitz, “Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex,” J. Cereb. Blood Flow Metab. 24(7), 744–755 (2004).
[Crossref] [PubMed]

Hutchins, P. M.

P. M. Hutchins, V. L. Roddick, and J. W. Dusseau, “Correlation of blood-pressure and rarefaction of small arterioles in back-crossed spontaneously hypertensive rats,” Microvasc. Res. 21, 246–9999 (1981).

Imai, T.

T. Kusaka, Y. Hisamatsu, K. Kawada, K. Okubo, H. Okada, M. Namba, T. Imai, K. Isobe, and S. Itoh, “Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia,” Opt. Rev. 10(5), 466–469 (2003).
[Crossref]

Isobe, K.

T. Kusaka, Y. Hisamatsu, K. Kawada, K. Okubo, H. Okada, M. Namba, T. Imai, K. Isobe, and S. Itoh, “Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia,” Opt. Rev. 10(5), 466–469 (2003).
[Crossref]

Itoh, S.

T. Kusaka, Y. Hisamatsu, K. Kawada, K. Okubo, H. Okada, M. Namba, T. Imai, K. Isobe, and S. Itoh, “Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia,” Opt. Rev. 10(5), 466–469 (2003).
[Crossref]

Izrailtyan, I.

C. W. Du, A. P. Koretsky, I. Izrailtyan, and H. Benveniste, “Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using diffuse reflectance and fluorescence,” J. Cereb. Blood Flow Metab. 25(8), 1078–1092 (2005).
[Crossref] [PubMed]

Jain, R. K.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

Jia, Y. L.

Y. L. Jia, J. Qin, Z. W. Zhi, and R. K. K. Wang, “Ultrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice,” J. Biomed. Opt. 16(8), 086004 (2011).
[Crossref] [PubMed]

Jiang, J. Y.

J. Qin, J. Y. Jiang, L. An, D. Gareau, and R. K. Wang, “In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography,” Lasers Surg. Med. 43(2), 122–129 (2011).
[Crossref] [PubMed]

Johnston, D.

M. Jones, J. Berwick, D. Johnston, and J. Mayhew, “Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex,” Neuroimage 13(6), 1002–1015 (2001).
[Crossref] [PubMed]

Jones, M.

M. Jones, J. Berwick, D. Johnston, and J. Mayhew, “Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex,” Neuroimage 13(6), 1002–1015 (2001).
[Crossref] [PubMed]

Kamp, G.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of Intraocular Distances by Backscattering Spectral Interferometry,” Opt. Commun. 117(1-2), 43–48 (1995).
[Crossref]

Kapitola, J.

S. Trojan and J. Kapitola, “Reaktivní hyperémie mozku potkana po výskové hypoxii [Reactive hyperemia in the brain of rats after high altitude hypoxia],” Sb. Lek. 92(4), 97–102 (1990).
[PubMed]

Kawada, K.

T. Kusaka, Y. Hisamatsu, K. Kawada, K. Okubo, H. Okada, M. Namba, T. Imai, K. Isobe, and S. Itoh, “Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia,” Opt. Rev. 10(5), 466–469 (2003).
[Crossref]

Kelly, K.

M. E. Seaman, S. M. Peirce, and K. Kelly, “Rapid analysis of vessel elements (RAVE): a tool for studying physiologic, pathologic and tumor angiogenesis,” PLoS ONE 6(6), e20807 (2011).
[Crossref] [PubMed]

Kirkpatrick, S. J.

Ko, T. H.

Koretsky, A. P.

C. W. Du, A. P. Koretsky, I. Izrailtyan, and H. Benveniste, “Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using diffuse reflectance and fluorescence,” J. Cereb. Blood Flow Metab. 25(8), 1078–1092 (2005).
[Crossref] [PubMed]

Kowalczyk, A.

Kral, J. G.

D. L. Crandall, G. J. Hausman, and J. G. Kral, “A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives,” Microcirculation 4(2), 211–232 (1997).
[Crossref] [PubMed]

Kusaka, T.

T. Kusaka, Y. Hisamatsu, K. Kawada, K. Okubo, H. Okada, M. Namba, T. Imai, K. Isobe, and S. Itoh, “Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia,” Opt. Rev. 10(5), 466–469 (2003).
[Crossref]

Lanning, R. M.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

Lanzillo, B.

V. Provitera, M. Nolano, N. Pappone, E. Lubrano, A. Stancanelli, B. Lanzillo, and L. Santoro, “Axonal degeneration in systemic sclerosis can be reverted by factors improving tissue oxygenation,” Rheumatology (Oxford) 46(11), 1739–1741 (2007).
[Crossref] [PubMed]

Latham, L. P.

W. W. Wagner, L. P. Latham, and R. L. Capen, “Capillary recruitment during airway hypoxia: role of pulmonary artery pressure,” J. Appl. Physiol. 47(2), 383–387 (1979).
[PubMed]

Lauritzen, M.

D. Attwell, A. M. Buchan, S. Charpak, M. Lauritzen, B. A. Macvicar, and E. A. Newman, “Glial and neuronal control of brain blood flow,” Nature 468(7321), 232–243 (2010).
[Crossref] [PubMed]

Lehman, R. A. W.

S. C. Bondy, R. A. W. Lehman, and J. L. Purdy, “Visual attention affects brain blood flow,” Nature 248(5447), 440–441 (1974).
[Crossref] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Lipowsky, H. H.

K. Parthasarathi and H. H. Lipowsky, “Capillary recruitment in response to tissue hypoxia and its dependence on red blood cell deformability,” Am. J. Physiol. 277(6 Pt 2), H2145–H2157 (1999).
[PubMed]

Lombardini, R.

G. Ciuffetti, L. Pasqualini, M. Pirro, R. Lombardini, M. De Sio, G. Schillaci, and E. Mannarino, “Blood rheology in men with essential hypertension and capillary rarefaction,” J. Hum. Hypertens. 16(8), 533–537 (2002).
[Crossref] [PubMed]

Lubrano, E.

V. Provitera, M. Nolano, N. Pappone, E. Lubrano, A. Stancanelli, B. Lanzillo, and L. Santoro, “Axonal degeneration in systemic sclerosis can be reverted by factors improving tissue oxygenation,” Rheumatology (Oxford) 46(11), 1739–1741 (2007).
[Crossref] [PubMed]

Luo, Z.

Ma, Z. H.

Macvicar, B. A.

D. Attwell, A. M. Buchan, S. Charpak, M. Lauritzen, B. A. Macvicar, and E. A. Newman, “Glial and neuronal control of brain blood flow,” Nature 468(7321), 232–243 (2010).
[Crossref] [PubMed]

Mannarino, E.

G. Ciuffetti, L. Pasqualini, M. Pirro, R. Lombardini, M. De Sio, G. Schillaci, and E. Mannarino, “Blood rheology in men with essential hypertension and capillary rarefaction,” J. Hum. Hypertens. 16(8), 533–537 (2002).
[Crossref] [PubMed]

Maslov, K.

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref] [PubMed]

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Imaging acute thermal burns by photoacoustic microscopy,” J. Biomed. Opt. 11(5), 054033 (2006).
[Crossref] [PubMed]

Mayeur, C.

C. Mayeur, S. Campard, C. Richard, and J. L. Teboul, “Comparison of four different vascular occlusion tests for assessing reactive hyperemia using near-infrared spectroscopy,” Crit. Care Med. 39(4), 695–701 (2011).
[Crossref] [PubMed]

Mayhew, J.

M. Jones, J. Berwick, D. Johnston, and J. Mayhew, “Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex,” Neuroimage 13(6), 1002–1015 (2001).
[Crossref] [PubMed]

Moskowitz, M. A.

C. Ayata, A. K. Dunn, Y. Gursoy-OZdemir, Z. H. Huang, D. A. Boas, and M. A. Moskowitz, “Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex,” J. Cereb. Blood Flow Metab. 24(7), 744–755 (2004).
[Crossref] [PubMed]

A. K. Dunn, A. Devor, H. Bolay, M. L. Andermann, M. A. Moskowitz, A. M. Dale, and D. A. Boas, “Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation,” Opt. Lett. 28(1), 28–30 (2003).
[Crossref] [PubMed]

A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21(3), 195–201 (2001).
[Crossref] [PubMed]

Mulder, A. H.

A. H. Mulder, A. P. J. van Dijk, P. Smits, and C. J. Tack, “Real-time contrast imaging: a new method to monitor capillary recruitment in human forearm skeletal muscle,” Microcirculation 15(3), 203–213 (2008).
[Crossref] [PubMed]

Munn, L. L.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

Namba, M.

T. Kusaka, Y. Hisamatsu, K. Kawada, K. Okubo, H. Okada, M. Namba, T. Imai, K. Isobe, and S. Itoh, “Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia,” Opt. Rev. 10(5), 466–469 (2003).
[Crossref]

Newman, E. A.

D. Attwell, A. M. Buchan, S. Charpak, M. Lauritzen, B. A. Macvicar, and E. A. Newman, “Glial and neuronal control of brain blood flow,” Nature 468(7321), 232–243 (2010).
[Crossref] [PubMed]

Nguyen-Huynh, A. T.

H. M. Subhash, V. Davila, H. Sun, A. T. Nguyen-Huynh, X. R. Shi, A. L. Nuttall, and R. K. K. Wang, “Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography,” IEEE Trans. Med. Imaging 30(2), 224–230 (2011).
[Crossref] [PubMed]

Nirmala, S. R.

S. R. Nirmala, S. Dandapat, and P. M. Bora, “Wavelet weighted blood vessel distortion measure for retinal images,” Biomed. Signal Process. Control 5(4), 282–291 (2010).
[Crossref]

Nolano, M.

V. Provitera, M. Nolano, N. Pappone, E. Lubrano, A. Stancanelli, B. Lanzillo, and L. Santoro, “Axonal degeneration in systemic sclerosis can be reverted by factors improving tissue oxygenation,” Rheumatology (Oxford) 46(11), 1739–1741 (2007).
[Crossref] [PubMed]

Noon, J. P.

J. P. Noon, B. R. Walker, D. J. Webb, A. C. Shore, D. W. Holton, H. V. Edwards, and G. C. M. Watt, “Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure,” J. Clin. Invest. 99(8), 1873–1879 (1997).
[Crossref] [PubMed]

Nuttall, A. L.

H. M. Subhash, V. Davila, H. Sun, A. T. Nguyen-Huynh, X. R. Shi, A. L. Nuttall, and R. K. K. Wang, “Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography,” IEEE Trans. Med. Imaging 30(2), 224–230 (2011).
[Crossref] [PubMed]

Okada, H.

T. Kusaka, Y. Hisamatsu, K. Kawada, K. Okubo, H. Okada, M. Namba, T. Imai, K. Isobe, and S. Itoh, “Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia,” Opt. Rev. 10(5), 466–469 (2003).
[Crossref]

Okubo, K.

T. Kusaka, Y. Hisamatsu, K. Kawada, K. Okubo, H. Okada, M. Namba, T. Imai, K. Isobe, and S. Itoh, “Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia,” Opt. Rev. 10(5), 466–469 (2003).
[Crossref]

Padera, T. P.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

Pan, Y.

Pappone, N.

V. Provitera, M. Nolano, N. Pappone, E. Lubrano, A. Stancanelli, B. Lanzillo, and L. Santoro, “Axonal degeneration in systemic sclerosis can be reverted by factors improving tissue oxygenation,” Rheumatology (Oxford) 46(11), 1739–1741 (2007).
[Crossref] [PubMed]

Parthasarathi, K.

K. Parthasarathi and H. H. Lipowsky, “Capillary recruitment in response to tissue hypoxia and its dependence on red blood cell deformability,” Am. J. Physiol. 277(6 Pt 2), H2145–H2157 (1999).
[PubMed]

Pascarella, L.

L. Pascarella, G. W. Schmid Schönbein, and J. J. Bergan, “Microcirculation and venous ulcers: a review,” Ann. Vasc. Surg. 19(6), 921–927 (2005).
[Crossref] [PubMed]

Pasqualini, L.

G. Ciuffetti, L. Pasqualini, M. Pirro, R. Lombardini, M. De Sio, G. Schillaci, and E. Mannarino, “Blood rheology in men with essential hypertension and capillary rarefaction,” J. Hum. Hypertens. 16(8), 533–537 (2002).
[Crossref] [PubMed]

Peirce, S. M.

M. E. Seaman, S. M. Peirce, and K. Kelly, “Rapid analysis of vessel elements (RAVE): a tool for studying physiologic, pathologic and tumor angiogenesis,” PLoS ONE 6(6), e20807 (2011).
[Crossref] [PubMed]

Pfleger, S.

C. M. Wacker, A. W. Hartlep, M. Bock, S. Pfleger, G. Beck, G. van Kaick, L. R. Schad, and W. R. Bauer, “BOLD-MRI of the heart in patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery,” Circulation 98, 371–9999 (1998).

Pirro, M.

G. Ciuffetti, L. Pasqualini, M. Pirro, R. Lombardini, M. De Sio, G. Schillaci, and E. Mannarino, “Blood rheology in men with essential hypertension and capillary rarefaction,” J. Hum. Hypertens. 16(8), 533–537 (2002).
[Crossref] [PubMed]

Pitris, C.

S. A. Boppart, B. E. Bouma, C. Pitris, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “In vivo cellular optical coherence tomography imaging,” Nat. Med. 4(7), 861–865 (1998).
[Crossref] [PubMed]

Preiser, J. C.

D. De Backer, J. Creteur, J. C. Preiser, M. J. Dubois, and J. L. Vincent, “Microvascular blood flow is altered in patients with sepsis,” Am. J. Respir. Crit. Care Med. 166(1), 98–104 (2002).
[Crossref] [PubMed]

Price, L. L.

A. C. Sull, L. N. Vuong, L. L. Price, V. J. Srinivasan, I. Gorczynska, J. G. Fujimoto, J. S. Schuman, and J. S. Duker, “Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retina 30(2), 235–245 (2010).
[Crossref] [PubMed]

Provitera, V.

V. Provitera, M. Nolano, N. Pappone, E. Lubrano, A. Stancanelli, B. Lanzillo, and L. Santoro, “Axonal degeneration in systemic sclerosis can be reverted by factors improving tissue oxygenation,” Rheumatology (Oxford) 46(11), 1739–1741 (2007).
[Crossref] [PubMed]

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Purdy, J. L.

S. C. Bondy, R. A. W. Lehman, and J. L. Purdy, “Visual attention affects brain blood flow,” Nature 248(5447), 440–441 (1974).
[Crossref] [PubMed]

Qin, J.

J. Qin, J. Y. Jiang, L. An, D. Gareau, and R. K. Wang, “In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography,” Lasers Surg. Med. 43(2), 122–129 (2011).
[Crossref] [PubMed]

Y. L. Jia, J. Qin, Z. W. Zhi, and R. K. K. Wang, “Ultrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice,” J. Biomed. Opt. 16(8), 086004 (2011).
[Crossref] [PubMed]

L. An, J. Qin, and R. K. Wang, “Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds,” Opt. Express 18(8), 8220–8228 (2010).
[Crossref] [PubMed]

Quaresima, V.

M. Ferrari, T. Binzoni, and V. Quaresima, “Oxidative metabolism in muscle,” Philos. Trans. R. Soc. Lond. B Biol. Sci. 352(1354), 677–683 (1997).
[Crossref] [PubMed]

Reiser, H.

F. S. Sutherland, E. Stefansson, D. L. Hatchell, and H. Reiser, “Retinal oxygen consumption in vitro. The effect of diabetes mellitus, oxygen and glucose,” Acta Ophthalmol. (Copenh.) 68(6), 715–720 (1990).
[Crossref] [PubMed]

Reynolds, E. O. R.

S. Wray, M. Cope, D. T. Delpy, J. S. Wyatt, and E. O. R. Reynolds, “Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation,” Biochim. Biophys. Acta 933(1), 184–192 (1988).
[Crossref] [PubMed]

J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray, C. Richardson, and E. O. R. Reynolds, “Responses of cerebral vasculature to changes in arterial carbon-dioxide tension measured by near-infrared spectroscopy in newborn-infants,” Pediatr. Res. 22(2), 230–9999 (1987).
[Crossref]

Richard, C.

C. Mayeur, S. Campard, C. Richard, and J. L. Teboul, “Comparison of four different vascular occlusion tests for assessing reactive hyperemia using near-infrared spectroscopy,” Crit. Care Med. 39(4), 695–701 (2011).
[Crossref] [PubMed]

Richardson, C.

J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray, C. Richardson, and E. O. R. Reynolds, “Responses of cerebral vasculature to changes in arterial carbon-dioxide tension measured by near-infrared spectroscopy in newborn-infants,” Pediatr. Res. 22(2), 230–9999 (1987).
[Crossref]

Roddick, V. L.

P. M. Hutchins, V. L. Roddick, and J. W. Dusseau, “Correlation of blood-pressure and rarefaction of small arterioles in back-crossed spontaneously hypertensive rats,” Microvasc. Res. 21, 246–9999 (1981).

Rodrigues, E.

E. Tibiriçá, E. Rodrigues, R. A. Cobas, and M. B. Gomes, “Endothelial function in patients with type 1 diabetes evaluated by skin capillary recruitment,” Microvasc. Res. 73(2), 107–112 (2007).
[Crossref] [PubMed]

Santoro, L.

V. Provitera, M. Nolano, N. Pappone, E. Lubrano, A. Stancanelli, B. Lanzillo, and L. Santoro, “Axonal degeneration in systemic sclerosis can be reverted by factors improving tissue oxygenation,” Rheumatology (Oxford) 46(11), 1739–1741 (2007).
[Crossref] [PubMed]

Schad, L. R.

C. M. Wacker, A. W. Hartlep, M. Bock, S. Pfleger, G. Beck, G. van Kaick, L. R. Schad, and W. R. Bauer, “BOLD-MRI of the heart in patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery,” Circulation 98, 371–9999 (1998).

Schillaci, G.

G. Ciuffetti, L. Pasqualini, M. Pirro, R. Lombardini, M. De Sio, G. Schillaci, and E. Mannarino, “Blood rheology in men with essential hypertension and capillary rarefaction,” J. Hum. Hypertens. 16(8), 533–537 (2002).
[Crossref] [PubMed]

Schmid Schönbein, G. W.

L. Pascarella, G. W. Schmid Schönbein, and J. J. Bergan, “Microcirculation and venous ulcers: a review,” Ann. Vasc. Surg. 19(6), 921–927 (2005).
[Crossref] [PubMed]

Schrader, J.

J. Schrader, F. J. Haddy, and E. Gerlach, “Release of adenosine, inosine and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregulation and reactive hyperemia,” Pflugers Arch. 369(1), 1–6 (1977).
[Crossref] [PubMed]

Schulte, H.

H. Schulte, A. Sollevi, and M. Segerdahl, “The distribution of hyperaemia induced by skin burn injury is not correlated with the development of secondary punctate hyperalgesia,” J. Pain 5(4), 212–217 (2004).
[Crossref] [PubMed]

Schuman, J. S.

A. C. Sull, L. N. Vuong, L. L. Price, V. J. Srinivasan, I. Gorczynska, J. G. Fujimoto, J. S. Schuman, and J. S. Duker, “Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retina 30(2), 235–245 (2010).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Seaman, M. E.

M. E. Seaman, S. M. Peirce, and K. Kelly, “Rapid analysis of vessel elements (RAVE): a tool for studying physiologic, pathologic and tumor angiogenesis,” PLoS ONE 6(6), e20807 (2011).
[Crossref] [PubMed]

Segerdahl, M.

H. Schulte, A. Sollevi, and M. Segerdahl, “The distribution of hyperaemia induced by skin burn injury is not correlated with the development of secondary punctate hyperalgesia,” J. Pain 5(4), 212–217 (2004).
[Crossref] [PubMed]

Shi, X. R.

H. M. Subhash, V. Davila, H. Sun, A. T. Nguyen-Huynh, X. R. Shi, A. L. Nuttall, and R. K. K. Wang, “Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography,” IEEE Trans. Med. Imaging 30(2), 224–230 (2011).
[Crossref] [PubMed]

Shore, A. C.

J. P. Noon, B. R. Walker, D. J. Webb, A. C. Shore, D. W. Holton, H. V. Edwards, and G. C. M. Watt, “Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure,” J. Clin. Invest. 99(8), 1873–1879 (1997).
[Crossref] [PubMed]

Sinclair, J. I.

J. A. Eyre, T. J. H. Essex, P. A. Flecknell, P. H. Bartholomew, and J. I. Sinclair, “A comparison of measurements of cerebral blood flow in the rabbit using laser Doppler spectroscopy and radionuclide labelled microspheres,” Clin. Phys. Physiol. Meas. 9(1), 65–74 (1988).
[Crossref] [PubMed]

Smits, P.

A. H. Mulder, A. P. J. van Dijk, P. Smits, and C. J. Tack, “Real-time contrast imaging: a new method to monitor capillary recruitment in human forearm skeletal muscle,” Microcirculation 15(3), 203–213 (2008).
[Crossref] [PubMed]

Sollevi, A.

H. Schulte, A. Sollevi, and M. Segerdahl, “The distribution of hyperaemia induced by skin burn injury is not correlated with the development of secondary punctate hyperalgesia,” J. Pain 5(4), 212–217 (2004).
[Crossref] [PubMed]

Southern, J. F.

S. A. Boppart, B. E. Bouma, C. Pitris, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “In vivo cellular optical coherence tomography imaging,” Nat. Med. 4(7), 861–865 (1998).
[Crossref] [PubMed]

Srinivasan, V. J.

A. C. Sull, L. N. Vuong, L. L. Price, V. J. Srinivasan, I. Gorczynska, J. G. Fujimoto, J. S. Schuman, and J. S. Duker, “Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retina 30(2), 235–245 (2010).
[Crossref] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express 12(11), 2404–2422 (2004).
[Crossref] [PubMed]

Stancanelli, A.

V. Provitera, M. Nolano, N. Pappone, E. Lubrano, A. Stancanelli, B. Lanzillo, and L. Santoro, “Axonal degeneration in systemic sclerosis can be reverted by factors improving tissue oxygenation,” Rheumatology (Oxford) 46(11), 1739–1741 (2007).
[Crossref] [PubMed]

Stefansson, E.

F. S. Sutherland, E. Stefansson, D. L. Hatchell, and H. Reiser, “Retinal oxygen consumption in vitro. The effect of diabetes mellitus, oxygen and glucose,” Acta Ophthalmol. (Copenh.) 68(6), 715–720 (1990).
[Crossref] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Stoica, G.

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref] [PubMed]

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Imaging acute thermal burns by photoacoustic microscopy,” J. Biomed. Opt. 11(5), 054033 (2006).
[Crossref] [PubMed]

Stylianopoulos, T.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

Subhash, H. M.

H. M. Subhash, V. Davila, H. Sun, A. T. Nguyen-Huynh, X. R. Shi, A. L. Nuttall, and R. K. K. Wang, “Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography,” IEEE Trans. Med. Imaging 30(2), 224–230 (2011).
[Crossref] [PubMed]

Sull, A. C.

A. C. Sull, L. N. Vuong, L. L. Price, V. J. Srinivasan, I. Gorczynska, J. G. Fujimoto, J. S. Schuman, and J. S. Duker, “Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retina 30(2), 235–245 (2010).
[Crossref] [PubMed]

Sun, H.

H. M. Subhash, V. Davila, H. Sun, A. T. Nguyen-Huynh, X. R. Shi, A. L. Nuttall, and R. K. K. Wang, “Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography,” IEEE Trans. Med. Imaging 30(2), 224–230 (2011).
[Crossref] [PubMed]

Sutherland, F. S.

F. S. Sutherland, E. Stefansson, D. L. Hatchell, and H. Reiser, “Retinal oxygen consumption in vitro. The effect of diabetes mellitus, oxygen and glucose,” Acta Ophthalmol. (Copenh.) 68(6), 715–720 (1990).
[Crossref] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Tack, C. J.

A. H. Mulder, A. P. J. van Dijk, P. Smits, and C. J. Tack, “Real-time contrast imaging: a new method to monitor capillary recruitment in human forearm skeletal muscle,” Microcirculation 15(3), 203–213 (2008).
[Crossref] [PubMed]

Tearney, G. J.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

Teboul, J. L.

C. Mayeur, S. Campard, C. Richard, and J. L. Teboul, “Comparison of four different vascular occlusion tests for assessing reactive hyperemia using near-infrared spectroscopy,” Crit. Care Med. 39(4), 695–701 (2011).
[Crossref] [PubMed]

Tibiriçá, E.

E. Tibiriçá, E. Rodrigues, R. A. Cobas, and M. B. Gomes, “Endothelial function in patients with type 1 diabetes evaluated by skin capillary recruitment,” Microvasc. Res. 73(2), 107–112 (2007).
[Crossref] [PubMed]

Trojan, S.

S. Trojan and J. Kapitola, “Reaktivní hyperémie mozku potkana po výskové hypoxii [Reactive hyperemia in the brain of rats after high altitude hypoxia],” Sb. Lek. 92(4), 97–102 (1990).
[PubMed]

Tyrrell, J. A.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

Vakoc, B. J.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

van Dijk, A. P. J.

A. H. Mulder, A. P. J. van Dijk, P. Smits, and C. J. Tack, “Real-time contrast imaging: a new method to monitor capillary recruitment in human forearm skeletal muscle,” Microcirculation 15(3), 203–213 (2008).
[Crossref] [PubMed]

van Kaick, G.

C. M. Wacker, A. W. Hartlep, M. Bock, S. Pfleger, G. Beck, G. van Kaick, L. R. Schad, and W. R. Bauer, “BOLD-MRI of the heart in patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery,” Circulation 98, 371–9999 (1998).

Vincent, J. L.

D. De Backer, J. Creteur, J. C. Preiser, M. J. Dubois, and J. L. Vincent, “Microvascular blood flow is altered in patients with sepsis,” Am. J. Respir. Crit. Care Med. 166(1), 98–104 (2002).
[Crossref] [PubMed]

Vuong, L. N.

A. C. Sull, L. N. Vuong, L. L. Price, V. J. Srinivasan, I. Gorczynska, J. G. Fujimoto, J. S. Schuman, and J. S. Duker, “Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retina 30(2), 235–245 (2010).
[Crossref] [PubMed]

Wacker, C. M.

C. M. Wacker, A. W. Hartlep, M. Bock, S. Pfleger, G. Beck, G. van Kaick, L. R. Schad, and W. R. Bauer, “BOLD-MRI of the heart in patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery,” Circulation 98, 371–9999 (1998).

Wagner, W. W.

W. W. Wagner, L. P. Latham, and R. L. Capen, “Capillary recruitment during airway hypoxia: role of pulmonary artery pressure,” J. Appl. Physiol. 47(2), 383–387 (1979).
[PubMed]

Walker, B. R.

J. P. Noon, B. R. Walker, D. J. Webb, A. C. Shore, D. W. Holton, H. V. Edwards, and G. C. M. Watt, “Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure,” J. Clin. Invest. 99(8), 1873–1879 (1997).
[Crossref] [PubMed]

Wang, L. V.

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref] [PubMed]

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Imaging acute thermal burns by photoacoustic microscopy,” J. Biomed. Opt. 11(5), 054033 (2006).
[Crossref] [PubMed]

Wang, R. K.

J. Qin, J. Y. Jiang, L. An, D. Gareau, and R. K. Wang, “In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography,” Lasers Surg. Med. 43(2), 122–129 (2011).
[Crossref] [PubMed]

L. An and R. K. Wang, “Full range complex ultrahigh sensitive optical microangiography,” Opt. Lett. 36(6), 831–833 (2011).
[Crossref] [PubMed]

L. An, J. Qin, and R. K. Wang, “Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds,” Opt. Express 18(8), 8220–8228 (2010).
[Crossref] [PubMed]

L. An and R. K. Wang, “Use of a scanner to modulate spatial interferograms for in vivo full-range Fourier-domain optical coherence tomography,” Opt. Lett. 32(23), 3423–3425 (2007).
[Crossref] [PubMed]

R. K. Wang, “Three-dimensional optical micro-angiography maps directional blood perfusion deep within microcirculation tissue beds in vivo,” Phys. Med. Biol. 52(23), N531–N537 (2007).
[Crossref] [PubMed]

Wang, R. K. K.

R. K. K. Wang and L. An, “Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence tomography at 92-kHz line scan rate,” J. Biomed. Opt. 16(5), 050503 (2011).
[Crossref] [PubMed]

H. M. Subhash, V. Davila, H. Sun, A. T. Nguyen-Huynh, X. R. Shi, A. L. Nuttall, and R. K. K. Wang, “Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography,” IEEE Trans. Med. Imaging 30(2), 224–230 (2011).
[Crossref] [PubMed]

Y. L. Jia, J. Qin, Z. W. Zhi, and R. K. K. Wang, “Ultrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice,” J. Biomed. Opt. 16(8), 086004 (2011).
[Crossref] [PubMed]

L. An and R. K. K. Wang, “In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography,” Opt. Express 16(15), 11438–11452 (2008).
[Crossref] [PubMed]

R. K. K. Wang and Z. H. Ma, “Real-time flow imaging by removing texture pattern artifacts in spectral-domain optical Doppler tomography,” Opt. Lett. 31(20), 3001–3003 (2006).
[Crossref] [PubMed]

Watt, G. C. M.

J. P. Noon, B. R. Walker, D. J. Webb, A. C. Shore, D. W. Holton, H. V. Edwards, and G. C. M. Watt, “Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure,” J. Clin. Invest. 99(8), 1873–1879 (1997).
[Crossref] [PubMed]

Webb, D. J.

J. P. Noon, B. R. Walker, D. J. Webb, A. C. Shore, D. W. Holton, H. V. Edwards, and G. C. M. Watt, “Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure,” J. Clin. Invest. 99(8), 1873–1879 (1997).
[Crossref] [PubMed]

Wells-Gray, E. M.

Wojtkowski, M.

Wray, S.

S. Wray, M. Cope, D. T. Delpy, J. S. Wyatt, and E. O. R. Reynolds, “Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation,” Biochim. Biophys. Acta 933(1), 184–192 (1988).
[Crossref] [PubMed]

J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray, C. Richardson, and E. O. R. Reynolds, “Responses of cerebral vasculature to changes in arterial carbon-dioxide tension measured by near-infrared spectroscopy in newborn-infants,” Pediatr. Res. 22(2), 230–9999 (1987).
[Crossref]

Wyatt, J. S.

S. Wray, M. Cope, D. T. Delpy, J. S. Wyatt, and E. O. R. Reynolds, “Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation,” Biochim. Biophys. Acta 933(1), 184–192 (1988).
[Crossref] [PubMed]

J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray, C. Richardson, and E. O. R. Reynolds, “Responses of cerebral vasculature to changes in arterial carbon-dioxide tension measured by near-infrared spectroscopy in newborn-infants,” Pediatr. Res. 22(2), 230–9999 (1987).
[Crossref]

Yuan, Z.

Zhang, H. F.

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Imaging acute thermal burns by photoacoustic microscopy,” J. Biomed. Opt. 11(5), 054033 (2006).
[Crossref] [PubMed]

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref] [PubMed]

Zhi, Z. W.

Y. L. Jia, J. Qin, Z. W. Zhi, and R. K. K. Wang, “Ultrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice,” J. Biomed. Opt. 16(8), 086004 (2011).
[Crossref] [PubMed]

Acta Med. Scand. (1)

P. Horstmann, “The oxygen consumption in diabetes mellitus,” Acta Med. Scand. 139(4), 326–330 (1951).
[Crossref] [PubMed]

Acta Ophthalmol. (Copenh.) (1)

F. S. Sutherland, E. Stefansson, D. L. Hatchell, and H. Reiser, “Retinal oxygen consumption in vitro. The effect of diabetes mellitus, oxygen and glucose,” Acta Ophthalmol. (Copenh.) 68(6), 715–720 (1990).
[Crossref] [PubMed]

Am. J. Physiol. (2)

D. G. Crawford, H. M. Fairchild, and A. C. Guyton, “Oxygen lack as a possible cause of reactive hyperemia,” Am. J. Physiol. 197, 613–616 (1959).
[PubMed]

K. Parthasarathi and H. H. Lipowsky, “Capillary recruitment in response to tissue hypoxia and its dependence on red blood cell deformability,” Am. J. Physiol. 277(6 Pt 2), H2145–H2157 (1999).
[PubMed]

Am. J. Respir. Crit. Care Med. (1)

D. De Backer, J. Creteur, J. C. Preiser, M. J. Dubois, and J. L. Vincent, “Microvascular blood flow is altered in patients with sepsis,” Am. J. Respir. Crit. Care Med. 166(1), 98–104 (2002).
[Crossref] [PubMed]

Ann. Vasc. Surg. (1)

L. Pascarella, G. W. Schmid Schönbein, and J. J. Bergan, “Microcirculation and venous ulcers: a review,” Ann. Vasc. Surg. 19(6), 921–927 (2005).
[Crossref] [PubMed]

Biochim. Biophys. Acta (1)

S. Wray, M. Cope, D. T. Delpy, J. S. Wyatt, and E. O. R. Reynolds, “Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation,” Biochim. Biophys. Acta 933(1), 184–192 (1988).
[Crossref] [PubMed]

Biomed. Signal Process. Control (1)

S. R. Nirmala, S. Dandapat, and P. M. Bora, “Wavelet weighted blood vessel distortion measure for retinal images,” Biomed. Signal Process. Control 5(4), 282–291 (2010).
[Crossref]

Circulation (1)

C. M. Wacker, A. W. Hartlep, M. Bock, S. Pfleger, G. Beck, G. van Kaick, L. R. Schad, and W. R. Bauer, “BOLD-MRI of the heart in patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery,” Circulation 98, 371–9999 (1998).

Clin. Phys. Physiol. Meas. (1)

J. A. Eyre, T. J. H. Essex, P. A. Flecknell, P. H. Bartholomew, and J. I. Sinclair, “A comparison of measurements of cerebral blood flow in the rabbit using laser Doppler spectroscopy and radionuclide labelled microspheres,” Clin. Phys. Physiol. Meas. 9(1), 65–74 (1988).
[Crossref] [PubMed]

Crit. Care Med. (1)

C. Mayeur, S. Campard, C. Richard, and J. L. Teboul, “Comparison of four different vascular occlusion tests for assessing reactive hyperemia using near-infrared spectroscopy,” Crit. Care Med. 39(4), 695–701 (2011).
[Crossref] [PubMed]

IEEE Trans. Med. Imaging (1)

H. M. Subhash, V. Davila, H. Sun, A. T. Nguyen-Huynh, X. R. Shi, A. L. Nuttall, and R. K. K. Wang, “Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography,” IEEE Trans. Med. Imaging 30(2), 224–230 (2011).
[Crossref] [PubMed]

J. Appl. Physiol. (1)

W. W. Wagner, L. P. Latham, and R. L. Capen, “Capillary recruitment during airway hypoxia: role of pulmonary artery pressure,” J. Appl. Physiol. 47(2), 383–387 (1979).
[PubMed]

J. Biomed. Opt. (4)

D. A. Boas and A. K. Dunn, “Laser speckle contrast imaging in biomedical optics,” J. Biomed. Opt. 15(1), 011109 (2010).
[Crossref] [PubMed]

R. K. K. Wang and L. An, “Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence tomography at 92-kHz line scan rate,” J. Biomed. Opt. 16(5), 050503 (2011).
[Crossref] [PubMed]

Y. L. Jia, J. Qin, Z. W. Zhi, and R. K. K. Wang, “Ultrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice,” J. Biomed. Opt. 16(8), 086004 (2011).
[Crossref] [PubMed]

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Imaging acute thermal burns by photoacoustic microscopy,” J. Biomed. Opt. 11(5), 054033 (2006).
[Crossref] [PubMed]

J. Cereb. Blood Flow Metab. (3)

A. K. Dunn, H. Bolay, M. A. Moskowitz, and D. A. Boas, “Dynamic imaging of cerebral blood flow using laser speckle,” J. Cereb. Blood Flow Metab. 21(3), 195–201 (2001).
[Crossref] [PubMed]

C. W. Du, A. P. Koretsky, I. Izrailtyan, and H. Benveniste, “Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using diffuse reflectance and fluorescence,” J. Cereb. Blood Flow Metab. 25(8), 1078–1092 (2005).
[Crossref] [PubMed]

C. Ayata, A. K. Dunn, Y. Gursoy-OZdemir, Z. H. Huang, D. A. Boas, and M. A. Moskowitz, “Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex,” J. Cereb. Blood Flow Metab. 24(7), 744–755 (2004).
[Crossref] [PubMed]

J. Clin. Invest. (1)

J. P. Noon, B. R. Walker, D. J. Webb, A. C. Shore, D. W. Holton, H. V. Edwards, and G. C. M. Watt, “Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure,” J. Clin. Invest. 99(8), 1873–1879 (1997).
[Crossref] [PubMed]

J. Hum. Hypertens. (1)

G. Ciuffetti, L. Pasqualini, M. Pirro, R. Lombardini, M. De Sio, G. Schillaci, and E. Mannarino, “Blood rheology in men with essential hypertension and capillary rarefaction,” J. Hum. Hypertens. 16(8), 533–537 (2002).
[Crossref] [PubMed]

J. Pain (1)

H. Schulte, A. Sollevi, and M. Segerdahl, “The distribution of hyperaemia induced by skin burn injury is not correlated with the development of secondary punctate hyperalgesia,” J. Pain 5(4), 212–217 (2004).
[Crossref] [PubMed]

Lasers Surg. Med. (1)

J. Qin, J. Y. Jiang, L. An, D. Gareau, and R. K. Wang, “In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography,” Lasers Surg. Med. 43(2), 122–129 (2011).
[Crossref] [PubMed]

Microcirculation (2)

A. H. Mulder, A. P. J. van Dijk, P. Smits, and C. J. Tack, “Real-time contrast imaging: a new method to monitor capillary recruitment in human forearm skeletal muscle,” Microcirculation 15(3), 203–213 (2008).
[Crossref] [PubMed]

D. L. Crandall, G. J. Hausman, and J. G. Kral, “A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives,” Microcirculation 4(2), 211–232 (1997).
[Crossref] [PubMed]

Microvasc. Res. (2)

P. M. Hutchins, V. L. Roddick, and J. W. Dusseau, “Correlation of blood-pressure and rarefaction of small arterioles in back-crossed spontaneously hypertensive rats,” Microvasc. Res. 21, 246–9999 (1981).

E. Tibiriçá, E. Rodrigues, R. A. Cobas, and M. B. Gomes, “Endothelial function in patients with type 1 diabetes evaluated by skin capillary recruitment,” Microvasc. Res. 73(2), 107–112 (2007).
[Crossref] [PubMed]

Nat. Biotechnol. (1)

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref] [PubMed]

Nat. Med. (2)

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med. 15(10), 1219–1223 (2009).
[Crossref] [PubMed]

S. A. Boppart, B. E. Bouma, C. Pitris, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “In vivo cellular optical coherence tomography imaging,” Nat. Med. 4(7), 861–865 (1998).
[Crossref] [PubMed]

Nature (3)

S. C. Bondy, R. A. W. Lehman, and J. L. Purdy, “Visual attention affects brain blood flow,” Nature 248(5447), 440–441 (1974).
[Crossref] [PubMed]

G. Bell and A. M. Harper, “Measurement of regional blood flow through skin from clearance of krypton-85,” Nature 202(4933), 704–705 (1964).
[Crossref] [PubMed]

D. Attwell, A. M. Buchan, S. Charpak, M. Lauritzen, B. A. Macvicar, and E. A. Newman, “Glial and neuronal control of brain blood flow,” Nature 468(7321), 232–243 (2010).
[Crossref] [PubMed]

Neuroimage (1)

M. Jones, J. Berwick, D. Johnston, and J. Mayhew, “Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex,” Neuroimage 13(6), 1002–1015 (2001).
[Crossref] [PubMed]

Opt. Commun. (2)

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of Intraocular Distances by Backscattering Spectral Interferometry,” Opt. Commun. 117(1-2), 43–48 (1995).
[Crossref]

A. F. Fercher and J. D. Briers, “Flow Visualization by Means of Single-Exposure Speckle Photography,” Opt. Commun. 37(5), 326–330 (1981).
[Crossref]

Opt. Express (3)

Opt. Lett. (6)

Opt. Rev. (1)

T. Kusaka, Y. Hisamatsu, K. Kawada, K. Okubo, H. Okada, M. Namba, T. Imai, K. Isobe, and S. Itoh, “Measurement of cerebral optical pathlength as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia,” Opt. Rev. 10(5), 466–469 (2003).
[Crossref]

Pediatr. Res. (1)

J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray, C. Richardson, and E. O. R. Reynolds, “Responses of cerebral vasculature to changes in arterial carbon-dioxide tension measured by near-infrared spectroscopy in newborn-infants,” Pediatr. Res. 22(2), 230–9999 (1987).
[Crossref]

Pflugers Arch. (1)

J. Schrader, F. J. Haddy, and E. Gerlach, “Release of adenosine, inosine and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregulation and reactive hyperemia,” Pflugers Arch. 369(1), 1–6 (1977).
[Crossref] [PubMed]

Philos. Trans. R. Soc. Lond. B Biol. Sci. (1)

M. Ferrari, T. Binzoni, and V. Quaresima, “Oxidative metabolism in muscle,” Philos. Trans. R. Soc. Lond. B Biol. Sci. 352(1354), 677–683 (1997).
[Crossref] [PubMed]

Phys. Med. Biol. (1)

R. K. Wang, “Three-dimensional optical micro-angiography maps directional blood perfusion deep within microcirculation tissue beds in vivo,” Phys. Med. Biol. 52(23), N531–N537 (2007).
[Crossref] [PubMed]

PLoS ONE (1)

M. E. Seaman, S. M. Peirce, and K. Kelly, “Rapid analysis of vessel elements (RAVE): a tool for studying physiologic, pathologic and tumor angiogenesis,” PLoS ONE 6(6), e20807 (2011).
[Crossref] [PubMed]

Retina (1)

A. C. Sull, L. N. Vuong, L. L. Price, V. J. Srinivasan, I. Gorczynska, J. G. Fujimoto, J. S. Schuman, and J. S. Duker, “Comparison of spectral/Fourier domain optical coherence tomography instruments for assessment of normal macular thickness,” Retina 30(2), 235–245 (2010).
[Crossref] [PubMed]

Rheumatology (Oxford) (1)

V. Provitera, M. Nolano, N. Pappone, E. Lubrano, A. Stancanelli, B. Lanzillo, and L. Santoro, “Axonal degeneration in systemic sclerosis can be reverted by factors improving tissue oxygenation,” Rheumatology (Oxford) 46(11), 1739–1741 (2007).
[Crossref] [PubMed]

Sb. Lek. (1)

S. Trojan and J. Kapitola, “Reaktivní hyperémie mozku potkana po výskové hypoxii [Reactive hyperemia in the brain of rats after high altitude hypoxia],” Sb. Lek. 92(4), 97–102 (1990).
[PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (6)

Fig. 1
Fig. 1

Schematic diagram of the multi-functional optical imaging system. SLD: superluminescent diode, OC: optical circulator, PC: polarization controller, FL: focusing lens, LD: laser diode, CH: chopper, M: mirror, BS: beam splitter, AL: adjusting lens, C: camera, ZL: zoom lens. The insert is a photo of the mouse pinna. The smallest division on the ruler is 1 mm.

Fig. 2
Fig. 2

2-LSI diffuse reflectance and speckle contrast images of the mouse pinna. (A) Diffuse reflectance, and (B) speckle contrast image of the mouse pinna before the burn. (C) Diffuse reflectance, and (D) speckle contrast image of the mouse pinna after the burn. The circles indicate the burned area. The arrows indicate representative vessels that are affected by the burn injury. Color bar shows the speckle contrast value (K).

Fig. 3
Fig. 3

Color coded map of the relative change of blood flow (A), HbO (C), Hb (E) and HbT (G). Mean and standard deviations of the relative change of blood flow (B), HbO (D), Hb (F) and HbT (G), from the three regions of interest. The circle indicates the burned area.

Fig. 4
Fig. 4

Projection view image of the blood vessel network obtained by the OMAG method before (A) and after (B) the burn injury. The circle indicates the burned area and the arrows indicate the reference vessels from Fig. 2(B). Enlarged areas of the yellow (C) and blue (D) rectangles, where the left and right images belong to (A) and (B), respectively.

Fig. 5
Fig. 5

Vessel area density map multiplied by the black and white projection view image of the blood vessel network obtained by the OMAG method before (A) and after (B) the burn injury. The white square in (A) is the window size used to calculate the VAD. (C) Vessel area density of the dashed line in (A) and (B). (D) Mean and standard deviation of the VAD for the three ROI’s determined in Fig. 6.

Fig. 6
Fig. 6

Co-registered image of the change in blood flow image (Fig. 3A) with the projection view image of the blood vessel network obtained by the OMAG method after the injury (Fig. 4B). The color map is the same as in Fig. 3A. The grayscale of the OMAG image was inverted such that the blood vessels appear dark for better contrast.

Equations (2)

Equations on this page are rendered with MathJax. Learn more.

K= σ S I = { τ C 2T [ 1exp( 2T τ c ) ] } 0.5
[ ΔHbO(t) ΔHb(t) ]= [ ε HbO λ 1 ε Hb λ 1 ε HbO λ 2 ε Hb λ 2 ] 1 [ ln( R λ 1 (0) R λ 1 (t) ) L λ 1 ln( R λ 2 (0) R λ 2 (t) ) L λ 2 ]

Metrics