Abstract

Intravascular optical coherence tomography (iOCT) is being used to assess viability of new coronary artery stent designs. We developed a highly automated method for detecting stent struts and measuring tissue coverage. We trained a bagged decision trees classifier to classify candidate struts using features extracted from the images. With 12 best features identified by forward selection, recall (precision) were 90%–94% (85%–90%). Including struts deemed insufficiently bright for manual analysis, precision improved to 94%. Strut detection statistics approached variability of manual analysis. Differences between manual and automatic area measurements were 0.12 ± 0.20 mm2 and 0.11 ± 0.20 mm2 for stent and tissue areas, respectively. With proposed algorithms, analyst time per stent should significantly reduce from the 6–16 hours now required.

© 2012 OSA

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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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  7. S. Tahara, H. G. Bezerra, V. Sirbu, H. Kyono, G. Musumeci, N. Rosenthal, G. Guagliumi, and M. A. Costa, “Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial,” Heart96(19), 1574–1578 (2010).
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    [CrossRef] [PubMed]
  9. G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
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    [CrossRef] [PubMed]
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  21. Z. Wang, D. Chamie, H. Bezerra, D. L. Wilson, M. Costa, and A. M. Rollins, “Three-dimensional volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Proc. SPIE8213, 8213-34 (2012)
  22. Z. Wang, D. Chamie, H. G. Bezerra, H. Yamamoto, J. Kanovsky, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Biomed. Opt. Express3(6), 1413–1426 (2012).
    [CrossRef] [PubMed]
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    [CrossRef]
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2012

G. J. Ughi, T. Adriaenssens, K. Onsea, P. Kayaert, C. Dubois, P. Sinnaeve, M. Coosemans, W. Desmet, and J. D’hooge, “Automatic segmentation of in-vivo intra-coronary optical coherence tomography images to assess stent strut apposition and coverage,” Int. J. Cardiovasc. Imaging28(2), 229–241 (2012).
[CrossRef] [PubMed]

A. Wang, J. Eggermont, N. Dekker, H. M. Garcia-Garcia, R. Pawar, J. H. C. Reiber, and J. Dijkstra, “Automatic stent strut detection in intravascular optical coherence tomographic pullback runs,” Int. J. Cardiovasc. Imaging (2012).
[CrossRef] [PubMed]

S. Tsantis, G. C. Kagadis, K. Katsanos, D. Karnabatidis, G. Bourantas, and G. C. Nikiforidis, “Automatic vessel lumen segmentation and stent strut detection in intravascular optical coherence tomography,” Med. Phys.39(1), 503–513 (2012).
[CrossRef] [PubMed]

Z. Wang, D. Chamie, H. Bezerra, D. L. Wilson, M. Costa, and A. M. Rollins, “Three-dimensional volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Proc. SPIE8213, 8213-34 (2012)

Z. Wang, D. Chamie, H. G. Bezerra, H. Yamamoto, J. Kanovsky, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Biomed. Opt. Express3(6), 1413–1426 (2012).
[CrossRef] [PubMed]

2011

D. Chamié, Z. Wang, H. Bezerra, A. M. Rollins, and M. A. Costa, “Optical coherence tomography and fibrous cap characterization,” Curr Cardiovasc Imaging Rep4(4), 276–283 (2011).
[CrossRef] [PubMed]

N. Bruining, K. Sihan, J. Ligthart, P. Cummins, S. De Winter, and E. Regar, “Automated three-dimensional detection of intracoronary stent struts in optical coherence tomography images,” J. Am. Coll. Cardiol.58(20), B181 (2011).
[CrossRef]

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

C. Xu, J. M. Schmitt, T. Akasaka, T. Kubo, and K. Huang, “Automatic detection of stent struts with thick neointimal growth in intravascular optical coherence tomography image sequences,” Phys. Med. Biol.56(20), 6665–6675 (2011).
[CrossRef] [PubMed]

S. Tahara, D. Chamié, M. Baibars, C. Alraies, and M. Costa, “Optical coherence tomography endpoints in stent clinical investigations: strut coverage,” Int. J. Cardiovasc. Imaging27(2), 271–287 (2011).
[CrossRef] [PubMed]

2010

G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
[CrossRef] [PubMed]

M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
[CrossRef] [PubMed]

J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
[CrossRef] [PubMed]

G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

H. Kyono, G. Guagliumi, V. Sirbu, N. Rosenthal, S. Tahara, G. Musumeci, A. Trivisonno, H. G. Bezerra, and M. A. Costa, “Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations,” EuroIntervention6(1), 69–77 (2010).
[CrossRef] [PubMed]

S. Tahara, H. G. Bezerra, V. Sirbu, H. Kyono, G. Musumeci, N. Rosenthal, G. Guagliumi, and M. A. Costa, “Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial,” Heart96(19), 1574–1578 (2010).
[CrossRef] [PubMed]

C. Kauffmann, P. Motreff, and L. Sarry, “In vivo supervised analysis of stent reendothelialization from optical coherence tomography,” IEEE Trans. Med. Imaging29(3), 807–818 (2010).
[CrossRef] [PubMed]

Z. Wang, H. Kyono, H. G. Bezerra, H. Wang, M. Gargesha, C. Alraies, C. Xu, J. M. Schmitt, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Semiautomatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images,” J. Biomed. Opt.15(6), 061711 (2010).
[CrossRef] [PubMed]

2009

S. Gurmeric, G. G. Isguder, S. Carlier, and G. Unal, “A new 3-D automated computational method to evaluate in-stent neointimal hyperplasia in in-vivo intravascular optical coherence tomography pullbacks,” Med Image Comput Comput Assist Interv12(Pt 2), 776–785 (2009).
[PubMed]

H. G. Bezerra, M. A. Costa, G. Guagliumi, A. M. Rollins, and D. I. Simon, “Intracoronary optical coherence tomography: a comprehensive review clinical and research applications,” JACC Cardiovasc. Interv.2(11), 1035–1046 (2009).
[CrossRef] [PubMed]

2008

G. T. Bonnema, K. O. Cardinal, S. K. Williams, and J. K. Barton, “An automatic algorithm for detecting stent endothelialization from volumetric optical coherence tomography datasets,” Phys. Med. Biol.53(12), 3083–3098 (2008).
[CrossRef] [PubMed]

2002

P. Bühlmann and B. Yu, “Analyzing bagging,” Ann. Stat.30(4), 927–961 (2002).
[CrossRef]

1996

L. Breiman, “Bagging predictors,” Mach. Learn.24(2), 123–140 (1996).
[CrossRef]

1989

E. T. Y. Lee, “Choosing nodes in parametric curve interpolation,” Comput. Aided Des.21(6), 363–370 (1989).
[CrossRef]

1983

N. Y. Graham, “Smoothing with periodic cubic splines,” Bell Syst. Tech. J.62, 101–110 (1983).

Aboodi, M. S.

J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
[CrossRef] [PubMed]

Adriaenssens, T.

G. J. Ughi, T. Adriaenssens, K. Onsea, P. Kayaert, C. Dubois, P. Sinnaeve, M. Coosemans, W. Desmet, and J. D’hooge, “Automatic segmentation of in-vivo intra-coronary optical coherence tomography images to assess stent strut apposition and coverage,” Int. J. Cardiovasc. Imaging28(2), 229–241 (2012).
[CrossRef] [PubMed]

Akasaka, T.

C. Xu, J. M. Schmitt, T. Akasaka, T. Kubo, and K. Huang, “Automatic detection of stent struts with thick neointimal growth in intravascular optical coherence tomography image sequences,” Phys. Med. Biol.56(20), 6665–6675 (2011).
[CrossRef] [PubMed]

Allocco, D. J.

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

Alraies, C.

S. Tahara, D. Chamié, M. Baibars, C. Alraies, and M. Costa, “Optical coherence tomography endpoints in stent clinical investigations: strut coverage,” Int. J. Cardiovasc. Imaging27(2), 271–287 (2011).
[CrossRef] [PubMed]

Z. Wang, H. Kyono, H. G. Bezerra, H. Wang, M. Gargesha, C. Alraies, C. Xu, J. M. Schmitt, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Semiautomatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images,” J. Biomed. Opt.15(6), 061711 (2010).
[CrossRef] [PubMed]

Aprile, A.

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

Baan, J.

M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
[CrossRef] [PubMed]

Baibars, M.

S. Tahara, D. Chamié, M. Baibars, C. Alraies, and M. Costa, “Optical coherence tomography endpoints in stent clinical investigations: strut coverage,” Int. J. Cardiovasc. Imaging27(2), 271–287 (2011).
[CrossRef] [PubMed]

Barton, J. K.

G. T. Bonnema, K. O. Cardinal, S. K. Williams, and J. K. Barton, “An automatic algorithm for detecting stent endothelialization from volumetric optical coherence tomography datasets,” Phys. Med. Biol.53(12), 3083–3098 (2008).
[CrossRef] [PubMed]

Beijk, M. A.

M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
[CrossRef] [PubMed]

Bezerra, H.

Z. Wang, D. Chamie, H. Bezerra, D. L. Wilson, M. Costa, and A. M. Rollins, “Three-dimensional volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Proc. SPIE8213, 8213-34 (2012)

D. Chamié, Z. Wang, H. Bezerra, A. M. Rollins, and M. A. Costa, “Optical coherence tomography and fibrous cap characterization,” Curr Cardiovasc Imaging Rep4(4), 276–283 (2011).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
[CrossRef] [PubMed]

Bezerra, H. G.

Z. Wang, D. Chamie, H. G. Bezerra, H. Yamamoto, J. Kanovsky, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Biomed. Opt. Express3(6), 1413–1426 (2012).
[CrossRef] [PubMed]

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
[CrossRef] [PubMed]

H. Kyono, G. Guagliumi, V. Sirbu, N. Rosenthal, S. Tahara, G. Musumeci, A. Trivisonno, H. G. Bezerra, and M. A. Costa, “Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations,” EuroIntervention6(1), 69–77 (2010).
[CrossRef] [PubMed]

S. Tahara, H. G. Bezerra, V. Sirbu, H. Kyono, G. Musumeci, N. Rosenthal, G. Guagliumi, and M. A. Costa, “Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial,” Heart96(19), 1574–1578 (2010).
[CrossRef] [PubMed]

Z. Wang, H. Kyono, H. G. Bezerra, H. Wang, M. Gargesha, C. Alraies, C. Xu, J. M. Schmitt, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Semiautomatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images,” J. Biomed. Opt.15(6), 061711 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

H. G. Bezerra, M. A. Costa, G. Guagliumi, A. M. Rollins, and D. I. Simon, “Intracoronary optical coherence tomography: a comprehensive review clinical and research applications,” JACC Cardiovasc. Interv.2(11), 1035–1046 (2009).
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G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
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G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
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S. Gurmeric, G. G. Isguder, S. Carlier, and G. Unal, “A new 3-D automated computational method to evaluate in-stent neointimal hyperplasia in in-vivo intravascular optical coherence tomography pullbacks,” Med Image Comput Comput Assist Interv12(Pt 2), 776–785 (2009).
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Z. Wang, D. Chamie, H. G. Bezerra, H. Yamamoto, J. Kanovsky, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Biomed. Opt. Express3(6), 1413–1426 (2012).
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S. Tahara, D. Chamié, M. Baibars, C. Alraies, and M. Costa, “Optical coherence tomography endpoints in stent clinical investigations: strut coverage,” Int. J. Cardiovasc. Imaging27(2), 271–287 (2011).
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G. J. Ughi, T. Adriaenssens, K. Onsea, P. Kayaert, C. Dubois, P. Sinnaeve, M. Coosemans, W. Desmet, and J. D’hooge, “Automatic segmentation of in-vivo intra-coronary optical coherence tomography images to assess stent strut apposition and coverage,” Int. J. Cardiovasc. Imaging28(2), 229–241 (2012).
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Z. Wang, D. Chamie, H. Bezerra, D. L. Wilson, M. Costa, and A. M. Rollins, “Three-dimensional volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Proc. SPIE8213, 8213-34 (2012)

S. Tahara, D. Chamié, M. Baibars, C. Alraies, and M. Costa, “Optical coherence tomography endpoints in stent clinical investigations: strut coverage,” Int. J. Cardiovasc. Imaging27(2), 271–287 (2011).
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G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
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Costa, M. A.

Z. Wang, D. Chamie, H. G. Bezerra, H. Yamamoto, J. Kanovsky, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Biomed. Opt. Express3(6), 1413–1426 (2012).
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D. Chamié, Z. Wang, H. Bezerra, A. M. Rollins, and M. A. Costa, “Optical coherence tomography and fibrous cap characterization,” Curr Cardiovasc Imaging Rep4(4), 276–283 (2011).
[CrossRef] [PubMed]

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
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H. Kyono, G. Guagliumi, V. Sirbu, N. Rosenthal, S. Tahara, G. Musumeci, A. Trivisonno, H. G. Bezerra, and M. A. Costa, “Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations,” EuroIntervention6(1), 69–77 (2010).
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S. Tahara, H. G. Bezerra, V. Sirbu, H. Kyono, G. Musumeci, N. Rosenthal, G. Guagliumi, and M. A. Costa, “Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial,” Heart96(19), 1574–1578 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

Z. Wang, H. Kyono, H. G. Bezerra, H. Wang, M. Gargesha, C. Alraies, C. Xu, J. M. Schmitt, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Semiautomatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images,” J. Biomed. Opt.15(6), 061711 (2010).
[CrossRef] [PubMed]

H. G. Bezerra, M. A. Costa, G. Guagliumi, A. M. Rollins, and D. I. Simon, “Intracoronary optical coherence tomography: a comprehensive review clinical and research applications,” JACC Cardiovasc. Interv.2(11), 1035–1046 (2009).
[CrossRef] [PubMed]

Cristea, E.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

Cummins, P.

N. Bruining, K. Sihan, J. Ligthart, P. Cummins, S. De Winter, and E. Regar, “Automated three-dimensional detection of intracoronary stent struts in optical coherence tomography images,” J. Am. Coll. Cardiol.58(20), B181 (2011).
[CrossRef]

D’hooge, J.

G. J. Ughi, T. Adriaenssens, K. Onsea, P. Kayaert, C. Dubois, P. Sinnaeve, M. Coosemans, W. Desmet, and J. D’hooge, “Automatic segmentation of in-vivo intra-coronary optical coherence tomography images to assess stent strut apposition and coverage,” Int. J. Cardiovasc. Imaging28(2), 229–241 (2012).
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G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
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M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
[CrossRef] [PubMed]

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N. Bruining, K. Sihan, J. Ligthart, P. Cummins, S. De Winter, and E. Regar, “Automated three-dimensional detection of intracoronary stent struts in optical coherence tomography images,” J. Am. Coll. Cardiol.58(20), B181 (2011).
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A. Wang, J. Eggermont, N. Dekker, H. M. Garcia-Garcia, R. Pawar, J. H. C. Reiber, and J. Dijkstra, “Automatic stent strut detection in intravascular optical coherence tomographic pullback runs,” Int. J. Cardiovasc. Imaging (2012).
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G. J. Ughi, T. Adriaenssens, K. Onsea, P. Kayaert, C. Dubois, P. Sinnaeve, M. Coosemans, W. Desmet, and J. D’hooge, “Automatic segmentation of in-vivo intra-coronary optical coherence tomography images to assess stent strut apposition and coverage,” Int. J. Cardiovasc. Imaging28(2), 229–241 (2012).
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A. Wang, J. Eggermont, N. Dekker, H. M. Garcia-Garcia, R. Pawar, J. H. C. Reiber, and J. Dijkstra, “Automatic stent strut detection in intravascular optical coherence tomographic pullback runs,” Int. J. Cardiovasc. Imaging (2012).
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G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

Dubois, C.

G. J. Ughi, T. Adriaenssens, K. Onsea, P. Kayaert, C. Dubois, P. Sinnaeve, M. Coosemans, W. Desmet, and J. D’hooge, “Automatic segmentation of in-vivo intra-coronary optical coherence tomography images to assess stent strut apposition and coverage,” Int. J. Cardiovasc. Imaging28(2), 229–241 (2012).
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A. Wang, J. Eggermont, N. Dekker, H. M. Garcia-Garcia, R. Pawar, J. H. C. Reiber, and J. Dijkstra, “Automatic stent strut detection in intravascular optical coherence tomographic pullback runs,” Int. J. Cardiovasc. Imaging (2012).
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G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
[CrossRef] [PubMed]

G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
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A. Wang, J. Eggermont, N. Dekker, H. M. Garcia-Garcia, R. Pawar, J. H. C. Reiber, and J. Dijkstra, “Automatic stent strut detection in intravascular optical coherence tomographic pullback runs,” Int. J. Cardiovasc. Imaging (2012).
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Z. Wang, H. Kyono, H. G. Bezerra, H. Wang, M. Gargesha, C. Alraies, C. Xu, J. M. Schmitt, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Semiautomatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images,” J. Biomed. Opt.15(6), 061711 (2010).
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J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
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Guagliumi, G.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
[CrossRef] [PubMed]

H. Kyono, G. Guagliumi, V. Sirbu, N. Rosenthal, S. Tahara, G. Musumeci, A. Trivisonno, H. G. Bezerra, and M. A. Costa, “Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations,” EuroIntervention6(1), 69–77 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
[CrossRef] [PubMed]

S. Tahara, H. G. Bezerra, V. Sirbu, H. Kyono, G. Musumeci, N. Rosenthal, G. Guagliumi, and M. A. Costa, “Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial,” Heart96(19), 1574–1578 (2010).
[CrossRef] [PubMed]

H. G. Bezerra, M. A. Costa, G. Guagliumi, A. M. Rollins, and D. I. Simon, “Intracoronary optical coherence tomography: a comprehensive review clinical and research applications,” JACC Cardiovasc. Interv.2(11), 1035–1046 (2009).
[CrossRef] [PubMed]

Gurmeric, S.

S. Gurmeric, G. G. Isguder, S. Carlier, and G. Unal, “A new 3-D automated computational method to evaluate in-stent neointimal hyperplasia in in-vivo intravascular optical coherence tomography pullbacks,” Med Image Comput Comput Assist Interv12(Pt 2), 776–785 (2009).
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M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
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C. Xu, J. M. Schmitt, T. Akasaka, T. Kubo, and K. Huang, “Automatic detection of stent struts with thick neointimal growth in intravascular optical coherence tomography image sequences,” Phys. Med. Biol.56(20), 6665–6675 (2011).
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J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
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S. Gurmeric, G. G. Isguder, S. Carlier, and G. Unal, “A new 3-D automated computational method to evaluate in-stent neointimal hyperplasia in in-vivo intravascular optical coherence tomography pullbacks,” Med Image Comput Comput Assist Interv12(Pt 2), 776–785 (2009).
[PubMed]

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S. Tsantis, G. C. Kagadis, K. Katsanos, D. Karnabatidis, G. Bourantas, and G. C. Nikiforidis, “Automatic vessel lumen segmentation and stent strut detection in intravascular optical coherence tomography,” Med. Phys.39(1), 503–513 (2012).
[CrossRef] [PubMed]

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J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
[CrossRef] [PubMed]

Kanovsky, J.

Karnabatidis, D.

S. Tsantis, G. C. Kagadis, K. Katsanos, D. Karnabatidis, G. Bourantas, and G. C. Nikiforidis, “Automatic vessel lumen segmentation and stent strut detection in intravascular optical coherence tomography,” Med. Phys.39(1), 503–513 (2012).
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Katsanos, K.

S. Tsantis, G. C. Kagadis, K. Katsanos, D. Karnabatidis, G. Bourantas, and G. C. Nikiforidis, “Automatic vessel lumen segmentation and stent strut detection in intravascular optical coherence tomography,” Med. Phys.39(1), 503–513 (2012).
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C. Kauffmann, P. Motreff, and L. Sarry, “In vivo supervised analysis of stent reendothelialization from optical coherence tomography,” IEEE Trans. Med. Imaging29(3), 807–818 (2010).
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G. J. Ughi, T. Adriaenssens, K. Onsea, P. Kayaert, C. Dubois, P. Sinnaeve, M. Coosemans, W. Desmet, and J. D’hooge, “Automatic segmentation of in-vivo intra-coronary optical coherence tomography images to assess stent strut apposition and coverage,” Int. J. Cardiovasc. Imaging28(2), 229–241 (2012).
[CrossRef] [PubMed]

Klomp, M.

M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
[CrossRef] [PubMed]

Koch, K. T.

M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
[CrossRef] [PubMed]

Kolodgie, F. D.

J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
[CrossRef] [PubMed]

Kubo, T.

C. Xu, J. M. Schmitt, T. Akasaka, T. Kubo, and K. Huang, “Automatic detection of stent struts with thick neointimal growth in intravascular optical coherence tomography image sequences,” Phys. Med. Biol.56(20), 6665–6675 (2011).
[CrossRef] [PubMed]

Kyono, H.

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

Z. Wang, H. Kyono, H. G. Bezerra, H. Wang, M. Gargesha, C. Alraies, C. Xu, J. M. Schmitt, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Semiautomatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images,” J. Biomed. Opt.15(6), 061711 (2010).
[CrossRef] [PubMed]

S. Tahara, H. G. Bezerra, V. Sirbu, H. Kyono, G. Musumeci, N. Rosenthal, G. Guagliumi, and M. A. Costa, “Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial,” Heart96(19), 1574–1578 (2010).
[CrossRef] [PubMed]

H. Kyono, G. Guagliumi, V. Sirbu, N. Rosenthal, S. Tahara, G. Musumeci, A. Trivisonno, H. G. Bezerra, and M. A. Costa, “Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations,” EuroIntervention6(1), 69–77 (2010).
[CrossRef] [PubMed]

Lansky, A. J.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

Lee, E. T. Y.

E. T. Y. Lee, “Choosing nodes in parametric curve interpolation,” Comput. Aided Des.21(6), 363–370 (1989).
[CrossRef]

Leon, M. B.

J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
[CrossRef] [PubMed]

Ligthart, J.

N. Bruining, K. Sihan, J. Ligthart, P. Cummins, S. De Winter, and E. Regar, “Automated three-dimensional detection of intracoronary stent struts in optical coherence tomography images,” J. Am. Coll. Cardiol.58(20), B181 (2011).
[CrossRef]

Lortkipanidze, N.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
[CrossRef] [PubMed]

Maehara, A.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

Matiashvili, A.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

Mehran, R.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

Mihalcsik, L.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

Milewski, K.

J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
[CrossRef] [PubMed]

Mintz, G. S.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

Motreff, P.

C. Kauffmann, P. Motreff, and L. Sarry, “In vivo supervised analysis of stent reendothelialization from optical coherence tomography,” IEEE Trans. Med. Imaging29(3), 807–818 (2010).
[CrossRef] [PubMed]

Musumeci, G.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
[CrossRef] [PubMed]

H. Kyono, G. Guagliumi, V. Sirbu, N. Rosenthal, S. Tahara, G. Musumeci, A. Trivisonno, H. G. Bezerra, and M. A. Costa, “Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations,” EuroIntervention6(1), 69–77 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
[CrossRef] [PubMed]

S. Tahara, H. G. Bezerra, V. Sirbu, H. Kyono, G. Musumeci, N. Rosenthal, G. Guagliumi, and M. A. Costa, “Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial,” Heart96(19), 1574–1578 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

Nakazawa, G.

J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
[CrossRef] [PubMed]

Nikiforidis, G. C.

S. Tsantis, G. C. Kagadis, K. Katsanos, D. Karnabatidis, G. Bourantas, and G. C. Nikiforidis, “Automatic vessel lumen segmentation and stent strut detection in intravascular optical coherence tomography,” Med. Phys.39(1), 503–513 (2012).
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Onsea, K.

G. J. Ughi, T. Adriaenssens, K. Onsea, P. Kayaert, C. Dubois, P. Sinnaeve, M. Coosemans, W. Desmet, and J. D’hooge, “Automatic segmentation of in-vivo intra-coronary optical coherence tomography images to assess stent strut apposition and coverage,” Int. J. Cardiovasc. Imaging28(2), 229–241 (2012).
[CrossRef] [PubMed]

Parise, H.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

Parker, S.

J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
[CrossRef] [PubMed]

Pawar, R.

A. Wang, J. Eggermont, N. Dekker, H. M. Garcia-Garcia, R. Pawar, J. H. C. Reiber, and J. Dijkstra, “Automatic stent strut detection in intravascular optical coherence tomographic pullback runs,” Int. J. Cardiovasc. Imaging (2012).
[CrossRef] [PubMed]

Piek, J. J.

M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
[CrossRef] [PubMed]

Popma, J. J.

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

Regar, E.

N. Bruining, K. Sihan, J. Ligthart, P. Cummins, S. De Winter, and E. Regar, “Automated three-dimensional detection of intracoronary stent struts in optical coherence tomography images,” J. Am. Coll. Cardiol.58(20), B181 (2011).
[CrossRef]

Reiber, J. H. C.

A. Wang, J. Eggermont, N. Dekker, H. M. Garcia-Garcia, R. Pawar, J. H. C. Reiber, and J. Dijkstra, “Automatic stent strut detection in intravascular optical coherence tomographic pullback runs,” Int. J. Cardiovasc. Imaging (2012).
[CrossRef] [PubMed]

Rollins, A. M.

Z. Wang, D. Chamie, H. G. Bezerra, H. Yamamoto, J. Kanovsky, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Biomed. Opt. Express3(6), 1413–1426 (2012).
[CrossRef] [PubMed]

Z. Wang, D. Chamie, H. Bezerra, D. L. Wilson, M. Costa, and A. M. Rollins, “Three-dimensional volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Proc. SPIE8213, 8213-34 (2012)

D. Chamié, Z. Wang, H. Bezerra, A. M. Rollins, and M. A. Costa, “Optical coherence tomography and fibrous cap characterization,” Curr Cardiovasc Imaging Rep4(4), 276–283 (2011).
[CrossRef] [PubMed]

Z. Wang, H. Kyono, H. G. Bezerra, H. Wang, M. Gargesha, C. Alraies, C. Xu, J. M. Schmitt, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Semiautomatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images,” J. Biomed. Opt.15(6), 061711 (2010).
[CrossRef] [PubMed]

H. G. Bezerra, M. A. Costa, G. Guagliumi, A. M. Rollins, and D. I. Simon, “Intracoronary optical coherence tomography: a comprehensive review clinical and research applications,” JACC Cardiovasc. Interv.2(11), 1035–1046 (2009).
[CrossRef] [PubMed]

Rosenthal, N.

H. Kyono, G. Guagliumi, V. Sirbu, N. Rosenthal, S. Tahara, G. Musumeci, A. Trivisonno, H. G. Bezerra, and M. A. Costa, “Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations,” EuroIntervention6(1), 69–77 (2010).
[CrossRef] [PubMed]

S. Tahara, H. G. Bezerra, V. Sirbu, H. Kyono, G. Musumeci, N. Rosenthal, G. Guagliumi, and M. A. Costa, “Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial,” Heart96(19), 1574–1578 (2010).
[CrossRef] [PubMed]

Rowland, S.

J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
[CrossRef] [PubMed]

Sarry, L.

C. Kauffmann, P. Motreff, and L. Sarry, “In vivo supervised analysis of stent reendothelialization from optical coherence tomography,” IEEE Trans. Med. Imaging29(3), 807–818 (2010).
[CrossRef] [PubMed]

Scheunhage, E.

M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
[CrossRef] [PubMed]

Schmitt, J. M.

C. Xu, J. M. Schmitt, T. Akasaka, T. Kubo, and K. Huang, “Automatic detection of stent struts with thick neointimal growth in intravascular optical coherence tomography image sequences,” Phys. Med. Biol.56(20), 6665–6675 (2011).
[CrossRef] [PubMed]

Z. Wang, H. Kyono, H. G. Bezerra, H. Wang, M. Gargesha, C. Alraies, C. Xu, J. M. Schmitt, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Semiautomatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images,” J. Biomed. Opt.15(6), 061711 (2010).
[CrossRef] [PubMed]

Sihan, K.

N. Bruining, K. Sihan, J. Ligthart, P. Cummins, S. De Winter, and E. Regar, “Automated three-dimensional detection of intracoronary stent struts in optical coherence tomography images,” J. Am. Coll. Cardiol.58(20), B181 (2011).
[CrossRef]

Simon, D. I.

H. G. Bezerra, M. A. Costa, G. Guagliumi, A. M. Rollins, and D. I. Simon, “Intracoronary optical coherence tomography: a comprehensive review clinical and research applications,” JACC Cardiovasc. Interv.2(11), 1035–1046 (2009).
[CrossRef] [PubMed]

Sinnaeve, P.

G. J. Ughi, T. Adriaenssens, K. Onsea, P. Kayaert, C. Dubois, P. Sinnaeve, M. Coosemans, W. Desmet, and J. D’hooge, “Automatic segmentation of in-vivo intra-coronary optical coherence tomography images to assess stent strut apposition and coverage,” Int. J. Cardiovasc. Imaging28(2), 229–241 (2012).
[CrossRef] [PubMed]

Sirbu, V.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

H. Kyono, G. Guagliumi, V. Sirbu, N. Rosenthal, S. Tahara, G. Musumeci, A. Trivisonno, H. G. Bezerra, and M. A. Costa, “Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations,” EuroIntervention6(1), 69–77 (2010).
[CrossRef] [PubMed]

G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

S. Tahara, H. G. Bezerra, V. Sirbu, H. Kyono, G. Musumeci, N. Rosenthal, G. Guagliumi, and M. A. Costa, “Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial,” Heart96(19), 1574–1578 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
[CrossRef] [PubMed]

Stone, G. W.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

Suzuki, N.

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
[CrossRef] [PubMed]

Tahara, S.

S. Tahara, D. Chamié, M. Baibars, C. Alraies, and M. Costa, “Optical coherence tomography endpoints in stent clinical investigations: strut coverage,” Int. J. Cardiovasc. Imaging27(2), 271–287 (2011).
[CrossRef] [PubMed]

H. Kyono, G. Guagliumi, V. Sirbu, N. Rosenthal, S. Tahara, G. Musumeci, A. Trivisonno, H. G. Bezerra, and M. A. Costa, “Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations,” EuroIntervention6(1), 69–77 (2010).
[CrossRef] [PubMed]

S. Tahara, H. G. Bezerra, V. Sirbu, H. Kyono, G. Musumeci, N. Rosenthal, G. Guagliumi, and M. A. Costa, “Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial,” Heart96(19), 1574–1578 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
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J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
[CrossRef] [PubMed]

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M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
[CrossRef] [PubMed]

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G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

H. Kyono, G. Guagliumi, V. Sirbu, N. Rosenthal, S. Tahara, G. Musumeci, A. Trivisonno, H. G. Bezerra, and M. A. Costa, “Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations,” EuroIntervention6(1), 69–77 (2010).
[CrossRef] [PubMed]

G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
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S. Tsantis, G. C. Kagadis, K. Katsanos, D. Karnabatidis, G. Bourantas, and G. C. Nikiforidis, “Automatic vessel lumen segmentation and stent strut detection in intravascular optical coherence tomography,” Med. Phys.39(1), 503–513 (2012).
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S. Gurmeric, G. G. Isguder, S. Carlier, and G. Unal, “A new 3-D automated computational method to evaluate in-stent neointimal hyperplasia in in-vivo intravascular optical coherence tomography pullbacks,” Med Image Comput Comput Assist Interv12(Pt 2), 776–785 (2009).
[PubMed]

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G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
[CrossRef] [PubMed]

G. Guagliumi, G. Musumeci, V. Sirbu, H. G. Bezerra, N. Suzuki, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Trivisonno, O. Valsecchi, G. Biondi-Zoccai, M. A. Costa, and ODESSA Trial Investigators, “Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents,” JACC Cardiovasc. Interv.3(5), 531–539 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
[CrossRef] [PubMed]

G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
[CrossRef] [PubMed]

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G. Guagliumi, V. Sirbu, G. Musumeci, H. G. Bezerra, A. Aprile, H. Kyono, L. Fiocca, A. Matiashvili, N. Lortkipanidze, A. Vassileva, J. J. Popma, D. J. Allocco, K. D. Dawkins, O. Valsecchi, and M. A. Costa, “Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI),” Circ Cardiovasc Interv3(4), 367–375 (2010).
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M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
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J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
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M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
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J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
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J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
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A. Wang, J. Eggermont, N. Dekker, H. M. Garcia-Garcia, R. Pawar, J. H. C. Reiber, and J. Dijkstra, “Automatic stent strut detection in intravascular optical coherence tomographic pullback runs,” Int. J. Cardiovasc. Imaging (2012).
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Z. Wang, D. Chamie, H. Bezerra, D. L. Wilson, M. Costa, and A. M. Rollins, “Three-dimensional volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Proc. SPIE8213, 8213-34 (2012)

D. Chamié, Z. Wang, H. Bezerra, A. M. Rollins, and M. A. Costa, “Optical coherence tomography and fibrous cap characterization,” Curr Cardiovasc Imaging Rep4(4), 276–283 (2011).
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Z. Wang, H. Kyono, H. G. Bezerra, H. Wang, M. Gargesha, C. Alraies, C. Xu, J. M. Schmitt, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Semiautomatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images,” J. Biomed. Opt.15(6), 061711 (2010).
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Z. Wang, D. Chamie, H. G. Bezerra, H. Yamamoto, J. Kanovsky, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Biomed. Opt. Express3(6), 1413–1426 (2012).
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Z. Wang, D. Chamie, H. Bezerra, D. L. Wilson, M. Costa, and A. M. Rollins, “Three-dimensional volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Proc. SPIE8213, 8213-34 (2012)

Z. Wang, H. Kyono, H. G. Bezerra, H. Wang, M. Gargesha, C. Alraies, C. Xu, J. M. Schmitt, D. L. Wilson, M. A. Costa, and A. M. Rollins, “Semiautomatic segmentation and quantification of calcified plaques in intracoronary optical coherence tomography images,” J. Biomed. Opt.15(6), 061711 (2010).
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J. F. Granada, S. Inami, M. S. Aboodi, A. Tellez, K. Milewski, D. Wallace-Bradley, S. Parker, S. Rowland, G. Nakazawa, M. Vorpahl, F. D. Kolodgie, G. L. Kaluza, M. B. Leon, and R. Virmani, “Development of a novel prohealing stent designed to deliver sirolimus from a biodegradable abluminal matrix,” Circ Cardiovasc Interv3(3), 257–266 (2010).
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Circulation

G. Guagliumi, M. A. Costa, V. Sirbu, G. Musumeci, H. G. Bezerra, N. Suzuki, A. Matiashvili, N. Lortkipanidze, L. Mihalcsik, A. Trivisonno, O. Valsecchi, G. S. Mintz, O. Dressler, H. Parise, A. Maehara, E. Cristea, A. J. Lansky, R. Mehran, and G. W. Stone, “Strut coverage and late malapposition with paclitaxel-eluting stents compared with bare metal stents in acute myocardial infarction: optical coherence tomography substudy of the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial,” Circulation123(3), 274–281 (2011).
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M. A. Beijk, M. Klomp, N. J. Verouden, N. van Geloven, K. T. Koch, J. P. Henriques, J. Baan, M. M. Vis, E. Scheunhage, J. J. Piek, J. G. Tijssen, and R. J. de Winter, “Genous endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study,” Eur. Heart J.31(9), 1055–1064 (2010).
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EuroIntervention

H. Kyono, G. Guagliumi, V. Sirbu, N. Rosenthal, S. Tahara, G. Musumeci, A. Trivisonno, H. G. Bezerra, and M. A. Costa, “Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations,” EuroIntervention6(1), 69–77 (2010).
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S. Tahara, H. G. Bezerra, V. Sirbu, H. Kyono, G. Musumeci, N. Rosenthal, G. Guagliumi, and M. A. Costa, “Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial,” Heart96(19), 1574–1578 (2010).
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S. Tahara, D. Chamié, M. Baibars, C. Alraies, and M. Costa, “Optical coherence tomography endpoints in stent clinical investigations: strut coverage,” Int. J. Cardiovasc. Imaging27(2), 271–287 (2011).
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G. Guagliumi, V. Sirbu, H. Bezerra, G. Biondi-Zoccai, L. Fiocca, G. Musumeci, A. Matiashvili, N. Lortkipanidze, S. Tahara, O. Valsecchi, and M. Costa, “Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study,” JACC Cardiovasc. Interv.3(6), 680–687 (2010).
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Med. Phys.

S. Tsantis, G. C. Kagadis, K. Katsanos, D. Karnabatidis, G. Bourantas, and G. C. Nikiforidis, “Automatic vessel lumen segmentation and stent strut detection in intravascular optical coherence tomography,” Med. Phys.39(1), 503–513 (2012).
[CrossRef] [PubMed]

Phys. Med. Biol.

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[CrossRef] [PubMed]

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[CrossRef] [PubMed]

Proc. SPIE

Z. Wang, D. Chamie, H. Bezerra, D. L. Wilson, M. Costa, and A. M. Rollins, “Three-dimensional volumetric quantification of fibrous caps using intravascular optical coherence tomography,” Proc. SPIE8213, 8213-34 (2012)

Other

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Figures (12)

Fig. 1
Fig. 1

Classification-based stent strut detection algorithm.

Fig. 2
Fig. 2

Shadow detection. (A) Intensity profile obtained by summing a predetermined number of pixels, SL, after the lumen border along A-lines in (C). (B) Intensity minima indicative of a shadow are shown (red solid line). The dashed curve is the H-minima transformation, which suppresses minima having a depth <TD1. Intensity minima obtained in (B) are used to generate the shadow mask in (D), where white bands indicate A-lines containing detected shadows. Note that even very thin shadows in the input image (C) are accurately detected. Parameters are given in the text.

Fig. 3
Fig. 3

Bright spot detection and expanded lumen boundary ROI. (A) Input (r,θ) image. (B) Image after h-maxima transformation with all the maxima whose depth is lower than TD2 suppressed, leaving a smoother image suitable for regional maxima detection. (C) Overlay of raw image, ROI mask (region between green lines), and extended maxima (in red) detected by taking the regional maxima of (B). (D) Candidate struts left after the logical AND of ROI mask, shadow mask, and extended maxima.

Fig. 4
Fig. 4

Change of algorithm performance as the number of features increases. 12 features give the best trade-off between precision and recall as marked by red cross on each curve.

Fig. 5
Fig. 5

Detection of bright, analyzable struts. (A) Input image from a baseline case. (B) Detection of “candidate struts” following Steps 1-3, including many FPs. (C) Struts following classification (Steps 4-5). (D) Final result after elimination of extra hits (Step 6), eliminating FPs at 3 o’clock and 7 o’clock.

Fig. 6
Fig. 6

Stent strut detection evaluation. The first and second groups of bars in each panel are from pooling fivefold cross validation (FFCV) and leave-one-stent-out (LOSO), respectively. Between candidate and classification steps, FPs are removed and precision increase significantly. There is little effect on recall. The two validation strategies gave similar results, indicative of generalizability.

Fig. 7
Fig. 7

Demonstration of non-bright and ambiguous struts. (A) Automated strut detection. Bright, analyzable struts (B) and non-bright struts (C) marked by analyst. (D, E) Magnified images of blue and green boxes, respectively, from panel A. Yellow arrows point to ambiguous struts detected automatically in A, but not marked as bright struts by analysts. Small bright reflection spots are evident, suggesting that the software gave proper responses even though these are FPs. Magenta arrows point to non-bright struts identified by analyst and not detected by software as a bright analyzable strut, because no bright reflection spots are present. Comparing A to B, there is a FN strut at 6 o’clock missed by software because it’s too close to the guide wire.

Fig. 8
Fig. 8

Stent contour formation. (A) With a large number of struts (green), a good stent contour is obtained (red). (B) With an insufficient number of detected struts, the stent contour can be in error. (C) The contour from B is corrected by automatically adding “interpolation points” (blue) between detected struts.

Fig. 9
Fig. 9

Lumen border segmentation. (A) Initial lumen border from dynamic programming, which includes errors due to struts on the lumen surface. (B) Lumen border refined by masking out A-lines containing struts prior to dynamic programming.

Fig. 10
Fig. 10

Bland-Altman plot of stent area measurement.

Fig. 11
Fig. 11

Bland-Altman plot of tissue coverage area measurement.

Fig. 12
Fig. 12

3D visualization of stent. Vessel wall is in red and detected struts are in white. 3D reconstruction shows the characteristic pattern of Xience stent (arrows).

Tables (2)

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Table 1 Features for classificationa

Tables Icon

Table 2 Stent strut detection evaluation statistics

Equations (3)

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Recall=TP/(TP+FN),
Precision=TP/(TP+FP),
F=2×(PR×RC)/(PR+PC).

Metrics