Abstract

We present a broad-band, continuous-wave spectral approach to quantify the baseline optical properties of tissue and changes in the concentration of a chromophore, which can assist to quantify the regional blood flow from dynamic contrast-enhanced near-infrared spectroscopy data. Experiments were conducted on phantoms and piglets. The baseline optical properties of tissue were determined by a multi-parameter wavelength-dependent data fit of a photon diffusion equation solution for a homogeneous medium. These baseline optical properties were used to find the changes in Indocyanine green concentration time course in the tissue. The changes were obtained by fitting the dynamic data at the peak wavelength of the chromophore absorption, which were used later to estimate the cerebral blood flow using a bolus tracking method.

© 2012 OSA

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    [CrossRef] [PubMed]

2012 (1)

2011 (1)

T. Marin and J. Moore, “Understanding near-infrared spectroscopy,” Adv. Neonatal Care11(6), 382–388 (2011).
[PubMed]

2010 (2)

O. Pucci, V. Toronov, and K. St Lawrence, “Measurement of the optical properties of a two-layer model of the human head using broadband near-infrared spectroscopy,” Appl. Opt.49(32), 6324–6332 (2010).
[CrossRef] [PubMed]

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt.15(3), 037014 (2010).
[CrossRef] [PubMed]

2009 (3)

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum.80(5), 054302 (2009).
[CrossRef] [PubMed]

A. A. Konstas, G. V. Goldmakher, T. Y. Lee, and M. H. Lev, “Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 1: Theoretic basis,” AJNR Am. J. Neuroradiol.30(4), 662–668 (2009).
[CrossRef] [PubMed]

A. A. Konstas, G. V. Goldmakher, T. Y. Lee, and M. H. Lev, “Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations,” AJNR Am. J. Neuroradiol.30(5), 885–892 (2009).
[CrossRef] [PubMed]

2007 (1)

D. G. Nabavi, R. Dittrich, S. P. Kloska, E. M. Nam, E. Klotz, W. Heindel, and E. B. Ringelstein, “Window narrowing: a new method for standardized assessment of the tissue at risk-maximum of infarction in CT based brain perfusion maps,” Neurol. Res.29(3), 296–303 (2007).
[CrossRef] [PubMed]

2005 (1)

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

2004 (1)

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

2002 (2)

R. J. Hunter, M. S. Patterson, T. J. Farrell, and J. E. Hayward, “Haemoglobin oxygenation of a two-layer tissue-simulating phantom from time-resolved reflectance: effect of top layer thickness,” Phys. Med. Biol.47(2), 193–208 (2002).
[CrossRef] [PubMed]

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res.51(5), 564–570 (2002).
[CrossRef] [PubMed]

2001 (1)

R. Springett, Y. Sakata, and D. T. Delpy, “Precise measurement of cerebral blood flow in newborn piglets from the bolus passage of indocyanine green,” Phys. Med. Biol.46(8), 2209–2225 (2001).
[CrossRef] [PubMed]

1999 (1)

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol.44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

1997 (1)

1994 (2)

S. Fantini, M. A. Franceschini, and E. Gratton, “Semi-infinite geometry boundary problem for light migration in highly scasttering media: a frequency domain study in the diffusion approximation,” J. Opt. Soc. Am.11(10), 2128–2138 (1994).
[CrossRef]

S. J. Matcher, M. Cope, and D. T. Delpy, “Use of the water absorption spectrum to quantify tissue chromophore concentration changes in near-infrared spectroscopy,” Phys. Med. Biol.39(1), 177–196 (1994).
[CrossRef] [PubMed]

1989 (1)

1988 (1)

D. T. Delpy, M. Cope, P. van der Zee, S. Arridge, S. Wray, and J. S. Wyatt, “Estimation of optical pathlength through tissue from direct time of flight measurement,” Phys. Med. Biol.33(12), 1433–1442 (1988).
[CrossRef] [PubMed]

1986 (1)

H. Q. Woodard and D. R. White, “The composition of body tissues,” Br. J. Radiol.59(708), 1209–1218 (1986).
[CrossRef] [PubMed]

1976 (1)

M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, “Light-absorbing properties, stability, and spectral stabilization of indocyanine green,” J. Appl. Physiol.40(4), 575–583 (1976).
[PubMed]

Arridge, S.

D. T. Delpy, M. Cope, P. van der Zee, S. Arridge, S. Wray, and J. S. Wyatt, “Estimation of optical pathlength through tissue from direct time of flight measurement,” Phys. Med. Biol.33(12), 1433–1442 (1988).
[CrossRef] [PubMed]

Barbier, E.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Borbély, K.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Brown, D. W.

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res.51(5), 564–570 (2002).
[CrossRef] [PubMed]

Caillé, J. M.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Chance, B.

Choi, J.

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

Cope, M.

S. J. Matcher, M. Cope, and D. T. Delpy, “Use of the water absorption spectrum to quantify tissue chromophore concentration changes in near-infrared spectroscopy,” Phys. Med. Biol.39(1), 177–196 (1994).
[CrossRef] [PubMed]

D. T. Delpy, M. Cope, P. van der Zee, S. Arridge, S. Wray, and J. S. Wyatt, “Estimation of optical pathlength through tissue from direct time of flight measurement,” Phys. Med. Biol.33(12), 1433–1442 (1988).
[CrossRef] [PubMed]

Delpy, D. T.

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res.51(5), 564–570 (2002).
[CrossRef] [PubMed]

R. Springett, Y. Sakata, and D. T. Delpy, “Precise measurement of cerebral blood flow in newborn piglets from the bolus passage of indocyanine green,” Phys. Med. Biol.46(8), 2209–2225 (2001).
[CrossRef] [PubMed]

S. J. Matcher, M. Cope, and D. T. Delpy, “Use of the water absorption spectrum to quantify tissue chromophore concentration changes in near-infrared spectroscopy,” Phys. Med. Biol.39(1), 177–196 (1994).
[CrossRef] [PubMed]

D. T. Delpy, M. Cope, P. van der Zee, S. Arridge, S. Wray, and J. S. Wyatt, “Estimation of optical pathlength through tissue from direct time of flight measurement,” Phys. Med. Biol.33(12), 1433–1442 (1988).
[CrossRef] [PubMed]

Dillon, W. P.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Diop, M.

J. T. Elliott, M. Diop, T. Y. Lee, and K. S. Lawrence, “Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters,” Opt. Lett.37(13), 2571–2573 (2012).
[CrossRef] [PubMed]

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt.15(3), 037014 (2010).
[CrossRef] [PubMed]

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum.80(5), 054302 (2009).
[CrossRef] [PubMed]

Dittrich, R.

D. G. Nabavi, R. Dittrich, S. P. Kloska, E. M. Nam, E. Klotz, W. Heindel, and E. B. Ringelstein, “Window narrowing: a new method for standardized assessment of the tissue at risk-maximum of infarction in CT based brain perfusion maps,” Neurol. Res.29(3), 296–303 (2007).
[CrossRef] [PubMed]

Dousset, V.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Eastwood, J. D.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Elliott, J. T.

J. T. Elliott, M. Diop, T. Y. Lee, and K. S. Lawrence, “Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters,” Opt. Lett.37(13), 2571–2573 (2012).
[CrossRef] [PubMed]

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt.15(3), 037014 (2010).
[CrossRef] [PubMed]

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum.80(5), 054302 (2009).
[CrossRef] [PubMed]

Fantini, S.

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol.44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

S. Fantini, M. A. Franceschini, and E. Gratton, “Semi-infinite geometry boundary problem for light migration in highly scasttering media: a frequency domain study in the diffusion approximation,” J. Opt. Soc. Am.11(10), 2128–2138 (1994).
[CrossRef]

Farrell, T. J.

R. J. Hunter, M. S. Patterson, T. J. Farrell, and J. E. Hayward, “Haemoglobin oxygenation of a two-layer tissue-simulating phantom from time-resolved reflectance: effect of top layer thickness,” Phys. Med. Biol.47(2), 193–208 (2002).
[CrossRef] [PubMed]

Franceschini, M. A.

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol.44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

S. Fantini, M. A. Franceschini, and E. Gratton, “Semi-infinite geometry boundary problem for light migration in highly scasttering media: a frequency domain study in the diffusion approximation,” J. Opt. Soc. Am.11(10), 2128–2138 (1994).
[CrossRef]

Glenn, T. C.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Goldmakher, G. V.

A. A. Konstas, G. V. Goldmakher, T. Y. Lee, and M. H. Lev, “Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 1: Theoretic basis,” AJNR Am. J. Neuroradiol.30(4), 662–668 (2009).
[CrossRef] [PubMed]

A. A. Konstas, G. V. Goldmakher, T. Y. Lee, and M. H. Lev, “Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations,” AJNR Am. J. Neuroradiol.30(5), 885–892 (2009).
[CrossRef] [PubMed]

Grandin, C. B.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Gratton, E.

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol.44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

S. Fantini, M. A. Franceschini, and E. Gratton, “Semi-infinite geometry boundary problem for light migration in highly scasttering media: a frequency domain study in the diffusion approximation,” J. Opt. Soc. Am.11(10), 2128–2138 (1994).
[CrossRef]

Gupta, R.

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

Hayward, J. E.

R. J. Hunter, M. S. Patterson, T. J. Farrell, and J. E. Hayward, “Haemoglobin oxygenation of a two-layer tissue-simulating phantom from time-resolved reflectance: effect of top layer thickness,” Phys. Med. Biol.47(2), 193–208 (2002).
[CrossRef] [PubMed]

Heindel, W.

D. G. Nabavi, R. Dittrich, S. P. Kloska, E. M. Nam, E. Klotz, W. Heindel, and E. B. Ringelstein, “Window narrowing: a new method for standardized assessment of the tissue at risk-maximum of infarction in CT based brain perfusion maps,” Neurol. Res.29(3), 296–303 (2007).
[CrossRef] [PubMed]

Hueber, D.

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol.44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

Hunter, R. J.

R. J. Hunter, M. S. Patterson, T. J. Farrell, and J. E. Hayward, “Haemoglobin oxygenation of a two-layer tissue-simulating phantom from time-resolved reflectance: effect of top layer thickness,” Phys. Med. Biol.47(2), 193–208 (2002).
[CrossRef] [PubMed]

Kienle, A.

Kloska, S. P.

D. G. Nabavi, R. Dittrich, S. P. Kloska, E. M. Nam, E. Klotz, W. Heindel, and E. B. Ringelstein, “Window narrowing: a new method for standardized assessment of the tissue at risk-maximum of infarction in CT based brain perfusion maps,” Neurol. Res.29(3), 296–303 (2007).
[CrossRef] [PubMed]

Klotz, E.

D. G. Nabavi, R. Dittrich, S. P. Kloska, E. M. Nam, E. Klotz, W. Heindel, and E. B. Ringelstein, “Window narrowing: a new method for standardized assessment of the tissue at risk-maximum of infarction in CT based brain perfusion maps,” Neurol. Res.29(3), 296–303 (2007).
[CrossRef] [PubMed]

Konstas, A. A.

A. A. Konstas, G. V. Goldmakher, T. Y. Lee, and M. H. Lev, “Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 1: Theoretic basis,” AJNR Am. J. Neuroradiol.30(4), 662–668 (2009).
[CrossRef] [PubMed]

A. A. Konstas, G. V. Goldmakher, T. Y. Lee, and M. H. Lev, “Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations,” AJNR Am. J. Neuroradiol.30(5), 885–892 (2009).
[CrossRef] [PubMed]

Kwant, G.

M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, “Light-absorbing properties, stability, and spectral stabilization of indocyanine green,” J. Appl. Physiol.40(4), 575–583 (1976).
[PubMed]

Landsman, M. L. J.

M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, “Light-absorbing properties, stability, and spectral stabilization of indocyanine green,” J. Appl. Physiol.40(4), 575–583 (1976).
[PubMed]

Lawrence, K. S.

Lee, T. Y.

J. T. Elliott, M. Diop, T. Y. Lee, and K. S. Lawrence, “Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters,” Opt. Lett.37(13), 2571–2573 (2012).
[CrossRef] [PubMed]

A. A. Konstas, G. V. Goldmakher, T. Y. Lee, and M. H. Lev, “Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 1: Theoretic basis,” AJNR Am. J. Neuroradiol.30(4), 662–668 (2009).
[CrossRef] [PubMed]

A. A. Konstas, G. V. Goldmakher, T. Y. Lee, and M. H. Lev, “Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations,” AJNR Am. J. Neuroradiol.30(5), 885–892 (2009).
[CrossRef] [PubMed]

Lee, T.-Y.

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt.15(3), 037014 (2010).
[CrossRef] [PubMed]

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum.80(5), 054302 (2009).
[CrossRef] [PubMed]

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res.51(5), 564–570 (2002).
[CrossRef] [PubMed]

Lev, M. H.

A. A. Konstas, G. V. Goldmakher, T. Y. Lee, and M. H. Lev, “Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations,” AJNR Am. J. Neuroradiol.30(5), 885–892 (2009).
[CrossRef] [PubMed]

A. A. Konstas, G. V. Goldmakher, T. Y. Lee, and M. H. Lev, “Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 1: Theoretic basis,” AJNR Am. J. Neuroradiol.30(4), 662–668 (2009).
[CrossRef] [PubMed]

Mantulin, W.

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

Marin, T.

T. Marin and J. Moore, “Understanding near-infrared spectroscopy,” Adv. Neonatal Care11(6), 382–388 (2011).
[PubMed]

Matcher, S. J.

S. J. Matcher, M. Cope, and D. T. Delpy, “Use of the water absorption spectrum to quantify tissue chromophore concentration changes in near-infrared spectroscopy,” Phys. Med. Biol.39(1), 177–196 (1994).
[CrossRef] [PubMed]

Maulik, D.

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol.44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

Michalos, A.

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

Mook, G. A.

M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, “Light-absorbing properties, stability, and spectral stabilization of indocyanine green,” J. Appl. Physiol.40(4), 575–583 (1976).
[PubMed]

Moore, J.

T. Marin and J. Moore, “Understanding near-infrared spectroscopy,” Adv. Neonatal Care11(6), 382–388 (2011).
[PubMed]

Nabavi, D. G.

D. G. Nabavi, R. Dittrich, S. P. Kloska, E. M. Nam, E. Klotz, W. Heindel, and E. B. Ringelstein, “Window narrowing: a new method for standardized assessment of the tissue at risk-maximum of infarction in CT based brain perfusion maps,” Neurol. Res.29(3), 296–303 (2007).
[CrossRef] [PubMed]

Naeini, J. G.

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res.51(5), 564–570 (2002).
[CrossRef] [PubMed]

Nam, E. M.

D. G. Nabavi, R. Dittrich, S. P. Kloska, E. M. Nam, E. Klotz, W. Heindel, and E. B. Ringelstein, “Window narrowing: a new method for standardized assessment of the tissue at risk-maximum of infarction in CT based brain perfusion maps,” Neurol. Res.29(3), 296–303 (2007).
[CrossRef] [PubMed]

Nariai, T.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Patterson, M. S.

Pedraza, S.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Picot, P. A.

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res.51(5), 564–570 (2002).
[CrossRef] [PubMed]

Polzonetti, C.

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

Pucci, O.

Ringelstein, E. B.

D. G. Nabavi, R. Dittrich, S. P. Kloska, E. M. Nam, E. Klotz, W. Heindel, and E. B. Ringelstein, “Window narrowing: a new method for standardized assessment of the tissue at risk-maximum of infarction in CT based brain perfusion maps,” Neurol. Res.29(3), 296–303 (2007).
[CrossRef] [PubMed]

Rosenfeld, W.

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol.44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

Safonova, L. P.

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

Sakata, Y.

R. Springett, Y. Sakata, and D. T. Delpy, “Precise measurement of cerebral blood flow in newborn piglets from the bolus passage of indocyanine green,” Phys. Med. Biol.46(8), 2209–2225 (2001).
[CrossRef] [PubMed]

Sesay, M.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Soustiel, J. F.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Springett, R.

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res.51(5), 564–570 (2002).
[CrossRef] [PubMed]

R. Springett, Y. Sakata, and D. T. Delpy, “Precise measurement of cerebral blood flow in newborn piglets from the bolus passage of indocyanine green,” Phys. Med. Biol.46(8), 2209–2225 (2001).
[CrossRef] [PubMed]

St Lawrence, K.

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt.15(3), 037014 (2010).
[CrossRef] [PubMed]

O. Pucci, V. Toronov, and K. St Lawrence, “Measurement of the optical properties of a two-layer model of the human head using broadband near-infrared spectroscopy,” Appl. Opt.49(32), 6324–6332 (2010).
[CrossRef] [PubMed]

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum.80(5), 054302 (2009).
[CrossRef] [PubMed]

Stankovic, M. R.

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol.44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

Stubblefield, P. G.

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol.44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

Tichauer, K. M.

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt.15(3), 037014 (2010).
[CrossRef] [PubMed]

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum.80(5), 054302 (2009).
[CrossRef] [PubMed]

Toronov, V.

O. Pucci, V. Toronov, and K. St Lawrence, “Measurement of the optical properties of a two-layer model of the human head using broadband near-infrared spectroscopy,” Appl. Opt.49(32), 6324–6332 (2010).
[CrossRef] [PubMed]

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

van der Zee, P.

D. T. Delpy, M. Cope, P. van der Zee, S. Arridge, S. Wray, and J. S. Wyatt, “Estimation of optical pathlength through tissue from direct time of flight measurement,” Phys. Med. Biol.33(12), 1433–1442 (1988).
[CrossRef] [PubMed]

White, D. R.

H. Q. Woodard and D. R. White, “The composition of body tissues,” Br. J. Radiol.59(708), 1209–1218 (1986).
[CrossRef] [PubMed]

Wilson, B. C.

Wintermark, M.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Wolf, M.

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

Wolf, U.

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

Woodard, H. Q.

H. Q. Woodard and D. R. White, “The composition of body tissues,” Br. J. Radiol.59(708), 1209–1218 (1986).
[CrossRef] [PubMed]

Wray, S.

D. T. Delpy, M. Cope, P. van der Zee, S. Arridge, S. Wray, and J. S. Wyatt, “Estimation of optical pathlength through tissue from direct time of flight measurement,” Phys. Med. Biol.33(12), 1433–1442 (1988).
[CrossRef] [PubMed]

Wyatt, J. S.

D. T. Delpy, M. Cope, P. van der Zee, S. Arridge, S. Wray, and J. S. Wyatt, “Estimation of optical pathlength through tissue from direct time of flight measurement,” Phys. Med. Biol.33(12), 1433–1442 (1988).
[CrossRef] [PubMed]

Yonas, H.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Zaharchuk, G.

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Zijlstra, W. G.

M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, “Light-absorbing properties, stability, and spectral stabilization of indocyanine green,” J. Appl. Physiol.40(4), 575–583 (1976).
[PubMed]

Adv. Neonatal Care (1)

T. Marin and J. Moore, “Understanding near-infrared spectroscopy,” Adv. Neonatal Care11(6), 382–388 (2011).
[PubMed]

AJNR Am. J. Neuroradiol. (2)

A. A. Konstas, G. V. Goldmakher, T. Y. Lee, and M. H. Lev, “Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 1: Theoretic basis,” AJNR Am. J. Neuroradiol.30(4), 662–668 (2009).
[CrossRef] [PubMed]

A. A. Konstas, G. V. Goldmakher, T. Y. Lee, and M. H. Lev, “Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations,” AJNR Am. J. Neuroradiol.30(5), 885–892 (2009).
[CrossRef] [PubMed]

Appl. Opt. (2)

Br. J. Radiol. (1)

H. Q. Woodard and D. R. White, “The composition of body tissues,” Br. J. Radiol.59(708), 1209–1218 (1986).
[CrossRef] [PubMed]

J. Appl. Physiol. (1)

M. L. J. Landsman, G. Kwant, G. A. Mook, and W. G. Zijlstra, “Light-absorbing properties, stability, and spectral stabilization of indocyanine green,” J. Appl. Physiol.40(4), 575–583 (1976).
[PubMed]

J. Biomed. Opt. (2)

J. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. P. Safonova, R. Gupta, A. Michalos, W. Mantulin, and E. Gratton, “Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach,” J. Biomed. Opt.9(1), 221–229 (2004).
[CrossRef] [PubMed]

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt.15(3), 037014 (2010).
[CrossRef] [PubMed]

J. Opt. Soc. Am. (1)

S. Fantini, M. A. Franceschini, and E. Gratton, “Semi-infinite geometry boundary problem for light migration in highly scasttering media: a frequency domain study in the diffusion approximation,” J. Opt. Soc. Am.11(10), 2128–2138 (1994).
[CrossRef]

J. Opt. Soc. Am. A (1)

Neurol. Res. (1)

D. G. Nabavi, R. Dittrich, S. P. Kloska, E. M. Nam, E. Klotz, W. Heindel, and E. B. Ringelstein, “Window narrowing: a new method for standardized assessment of the tissue at risk-maximum of infarction in CT based brain perfusion maps,” Neurol. Res.29(3), 296–303 (2007).
[CrossRef] [PubMed]

Opt. Lett. (1)

Pediatr. Res. (1)

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res.51(5), 564–570 (2002).
[CrossRef] [PubMed]

Phys. Med. Biol. (5)

D. T. Delpy, M. Cope, P. van der Zee, S. Arridge, S. Wray, and J. S. Wyatt, “Estimation of optical pathlength through tissue from direct time of flight measurement,” Phys. Med. Biol.33(12), 1433–1442 (1988).
[CrossRef] [PubMed]

S. J. Matcher, M. Cope, and D. T. Delpy, “Use of the water absorption spectrum to quantify tissue chromophore concentration changes in near-infrared spectroscopy,” Phys. Med. Biol.39(1), 177–196 (1994).
[CrossRef] [PubMed]

R. J. Hunter, M. S. Patterson, T. J. Farrell, and J. E. Hayward, “Haemoglobin oxygenation of a two-layer tissue-simulating phantom from time-resolved reflectance: effect of top layer thickness,” Phys. Med. Biol.47(2), 193–208 (2002).
[CrossRef] [PubMed]

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol.44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

R. Springett, Y. Sakata, and D. T. Delpy, “Precise measurement of cerebral blood flow in newborn piglets from the bolus passage of indocyanine green,” Phys. Med. Biol.46(8), 2209–2225 (2001).
[CrossRef] [PubMed]

Rev. Sci. Instrum. (1)

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum.80(5), 054302 (2009).
[CrossRef] [PubMed]

Stroke (1)

M. Wintermark, M. Sesay, E. Barbier, K. Borbély, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J. F. Soustiel, T. Nariai, G. Zaharchuk, J. M. Caillé, V. Dousset, and H. Yonas, “Comparative overview of brain perfusion imaging techniques,” Stroke36(9), e83–e99 (2005).
[CrossRef] [PubMed]

Other (5)

B. Hallacoglu, A. Sassaroli, M. Wysocki, E. Guerrero-Baruah, M. Beeri, V. Hartounian, M. Shaul, I. Rosenberg, A. M. Troen, and S. Fantini, “Absolute optical measurements of cerebral optical coefficients and hemoglobin concentrations in aging and younger human subjects,” in Biomedical Optics, OSA Technical Digest (Optical Society of America, 2012), paper BTu3A.61.

S. Chandrasekhar, Radiative Transfer (Oxford University Press, New York, 1960).

V. V. Sobolev and A. Treatise, Radiative Transfer (Van Nostrand-Reinhold, Prinston, NJ, 1963).

K. M. Case and P. Z. Zweifel, Linear Transport Theory (Addison-Wesley, Reading, MA, 1967).

A. Ishimaru, Wave Propagation and Scattering in Random Media (Academic, New York 1978).

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Figures (5)

Fig. 1
Fig. 1

Second derivative data fit.

Fig. 2
Fig. 2

First derivative fits for (a) infinite medium,10% milk: μ s = 3.6 mm−1, (%FCH2O) = 86%; (b) semi-infinite medium,10% milk: μ s = 3.6 mm−1, (%FCH2O) = 86%; (c) semi-infinite medium, 2% milk: μ s = 0.9 mm−1, (%FCH2O) = 97%

Fig. 3
Fig. 3

First derivative of absorbance for a set of data from pig’s open brain fit of the model (blue) to the base line data (red)

Fig. 4
Fig. 4

Fit of the model (blue) to the baseline data (red), R2 > 0.90 (a) baseline, (b) occlusion

Fig. 5
Fig. 5

Time traces of the brain ICG concentrations during baseline and occlusion

Tables (4)

Tables Icon

Table1 Optical properties of the open brain from recovered parameters of the fit

Tables Icon

Table 2 Properties of the piglet brain recovered from the fit, and the cerebral blood flow, blood volume and mean transit time values measured at two different conditions, baseline and occlusion for different animals

Tables Icon

Table 3 Comparison of reduced scattering coefficients obtained from two methods ( μ s 1 from the fit and μ s 2 by calculation from the DPF formula). The subscripts 1 and 2 refer to the 1st and 2nd derivative of absorbance methods.

Tables Icon

Table 4 Comparison of CBF measurement using continuous-wave NIRS with CT result

Equations (9)

Equations on this page are rendered with MathJax. Learn more.

ψ = 2 ( 4 π ) 2 S D exp [ ρ ( μ a D ) 1 / 2 ] ρ 3 [ 1 + ρ ( μ a D ) 1 / 2 ] ( z 0 + z b ) × [ z + 3 D ( 1 ( z 0 + z b ) 2 + 3 z 2 2 ρ 2 { 3 + ρ 2 μ a D 1 + ρ ( μ a D ) 1 / 2 } ) ] ,
z 0 = 3 D , z b = 2 D .
μ a = [ H b O 2 ] ε ( λ ) H b O 2 + [ H H b ] ε ( λ ) H H b + [ I C G ] ε ( λ ) I C G + ( % F C H 2 O ) μ a H 2 O + ( % F C f a t ) μ a f a t ,
μ s ( λ ) = M ( λ / 800 ) α
A ( λ ) = log 10 ( s i g n a l λ d a r k λ r e f e r e n c e λ d a r k λ ) ,
A = C ε L D P F + G ,
Δ C = Δ A ε L D P F ,
C t i s ( t ) = C B F 0 t C a ( τ ) R ( t τ ) d τ ,
D P F s i = 3 μ s 2 μ a 0 × ρ 3 μ s μ a 0 1 + ρ 3 μ s μ a 0 ,

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