Abstract

We present a case series of cornea and anterior segment disorders investigated by an office-based polarization-sensitive optical coherence tomography (PS-OCT). Blebs of glaucoma patients treated by trabeculectomy, and corneas of keratoconus and keratoplasty patients were measured by PS-OCT. Birefringence formations in trabeculectomy bleb were measured in 1 control eye and 3 eyes of trabeculectomy model rabbits. Polarization insensitive scattering OCT and the depth-resolved birefringence were measured simultaneously by PS-OCT. Abnormal birefringence was observed in keratoconus cases with advanced thinning and with a rupture of Descemet’s membrane. The graft-host interface of the keratoplasty case showed abnormal birefringence. The appearance of abnormal birefringence in the cornea was likely to be an indication of cross-linking of collagen fibrils. The measurement of rabbit showed abnormal birefringence in the scarring eyes. Wide regions of strong birefringence were observed in the eyes of trabeculectomy patients who had high intraocular pressure. Visualization of scarring in bleb by PS-OCT may be useful for the planning of secondary surgery. PS-OCT showed promising for the study and diagnosis diseases related to abnormal fibrous tissues of the cornea and anterior eye segment.

© 2011 OSA

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    [CrossRef] [PubMed]
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2011 (1)

F. G. Schlanitz, B. Baumann, T. Spalek, C. Schütze, C. Ahlers, M. Pircher, E. Götzinger, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Performance of automated drusen detection by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 52(7), 4571–4579 (2011).
[CrossRef]

2010 (3)

2009 (3)

2008 (7)

M. Miura, K. Kawana, T. Iwasaki, T. Kiuchi, T. Oshika, H. Mori, M. Yamanari, S. Makita, T. Yatagai, and Y. Yasuno, “Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy,” J. Glaucoma 17(3), 193–196 (2008).
[CrossRef] [PubMed]

Y. Zhang, Q. Wu, M. Zhang, B. W. Song, X. H. Du, and B. Lu, “Evaluating subconjunctival bleb function after trabeculectomy using slit-lamp optical coherence tomography and ultrasound biomicroscopy,” Chin. Med. J. (Engl.) 121(14), 1274–1279 (2008).
[PubMed]

A. G. Podoleanu and R. B. Rosen, “Combinations of techniques in imaging the retina with high resolution,” Prog. Retin. Eye Res. 27(4), 464–499 (2008).
[CrossRef]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt. 13(1), 014013 (2008).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci. 49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express 16(8), 5892–5906 (2008).
[CrossRef] [PubMed]

2007 (4)

R. A. Bone and G. Draper, “Optical anisotropy of the human cornea determined with a polarizing microscope,” Appl. Opt. 46(34), 8351–8357 (2007).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, I. Dejaco-Ruhswurm, S. Kaminski, C. Skorpik, and C. K. Hitzenberger, “Imaging of birefringent properties of keratoconus corneas by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(8), 3551–3558 (2007).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, and C. K. Hitzenberger, “Single camera based spectral domain polarization sensitive optical coherence tomography,” Opt. Express 15(3), 1054–1063 (2007).
[CrossRef] [PubMed]

M. Singh, P. T. Chew, D. S. Friedman, W. P. Nolan, J. L. See, S. D. Smith, C. Zheng, P. J. Foster, and T. Aung, “Imaging of trabeculectomy blebs using anterior segment optical coherence tomography,” Ophthalmology 114(1), 47–53 (2007).
[CrossRef] [PubMed]

2006 (1)

M. Pircher, E. Götzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Human macula investigated in vivo with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5487–5494 (2006).
[CrossRef] [PubMed]

2005 (1)

A. Labbé, B. Dupas, P. Hamard, and C. Baudouin, “In vivo confocal microscopy study of blebs after filtering surgery,” Ophthalmology 112(11), 1979.e1–1979.e9 (2005).
[CrossRef] [PubMed]

2004 (2)

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

2003 (1)

J. W. Jaronski and H. T. Kasprzak, “Linear birefringence measurements of the in vitro human cornea,” Ophthalmic Physiol. Opt. 23(4), 361–369 (2003).
[CrossRef] [PubMed]

2002 (2)

J. M. Bueno and F. Vargas-Martín, “Measurements of the corneal birefringence with a liquid-crystal imaging polariscope,” Appl. Opt. 41(1), 116–124 (2002).
[CrossRef] [PubMed]

J. F. de Boer and T. E. Milner, “Review of polarization sensitive optical coherence tomography and Stokes vector determination,” J. Biomed. Opt. 7(3), 359–371 (2002).
[CrossRef] [PubMed]

1994 (1)

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

1987 (1)

1953 (1)

A. Stanworth and E. J. Naylor, “Polarized light studies of the cornea: I. the isolated cornea,” J. Exp. Biol. 30, 160–163 (1953).

Ahlers, C.

F. G. Schlanitz, B. Baumann, T. Spalek, C. Schütze, C. Ahlers, M. Pircher, E. Götzinger, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Performance of automated drusen detection by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 52(7), 4571–4579 (2011).
[CrossRef]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

Arce-Diego, J. L.

F. Fanjul-Vélez, M. Pircher, B. Baumann, E. Götzinger, C. K. Hitzenberger, and J. L. Arce-Diego, “Polarimetric analysis of the human cornea measured by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(5), 056004 (2010).
[CrossRef] [PubMed]

Aung, T.

M. Singh, P. T. Chew, D. S. Friedman, W. P. Nolan, J. L. See, S. D. Smith, C. Zheng, P. J. Foster, and T. Aung, “Imaging of trabeculectomy blebs using anterior segment optical coherence tomography,” Ophthalmology 114(1), 47–53 (2007).
[CrossRef] [PubMed]

Baudouin, C.

A. Labbé, B. Dupas, P. Hamard, and C. Baudouin, “In vivo confocal microscopy study of blebs after filtering surgery,” Ophthalmology 112(11), 1979.e1–1979.e9 (2005).
[CrossRef] [PubMed]

Baumann, B.

F. G. Schlanitz, B. Baumann, T. Spalek, C. Schütze, C. Ahlers, M. Pircher, E. Götzinger, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Performance of automated drusen detection by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 52(7), 4571–4579 (2011).
[CrossRef]

F. Fanjul-Vélez, M. Pircher, B. Baumann, E. Götzinger, C. K. Hitzenberger, and J. L. Arce-Diego, “Polarimetric analysis of the human cornea measured by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(5), 056004 (2010).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, and C. K. Hitzenberger, “Single camera based spectral domain polarization sensitive optical coherence tomography,” Opt. Express 15(3), 1054–1063 (2007).
[CrossRef] [PubMed]

Bone, R. A.

Bueno, J. M.

Cense, B.

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Chen, T. C.

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

Chew, P. T.

M. Singh, P. T. Chew, D. S. Friedman, W. P. Nolan, J. L. See, S. D. Smith, C. Zheng, P. J. Foster, and T. Aung, “Imaging of trabeculectomy blebs using anterior segment optical coherence tomography,” Ophthalmology 114(1), 47–53 (2007).
[CrossRef] [PubMed]

de Boer, J. F.

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

J. F. de Boer and T. E. Milner, “Review of polarization sensitive optical coherence tomography and Stokes vector determination,” J. Biomed. Opt. 7(3), 359–371 (2002).
[CrossRef] [PubMed]

Dejaco-Ruhswurm, I.

E. Götzinger, M. Pircher, I. Dejaco-Ruhswurm, S. Kaminski, C. Skorpik, and C. K. Hitzenberger, “Imaging of birefringent properties of keratoconus corneas by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(8), 3551–3558 (2007).
[CrossRef] [PubMed]

Draper, G.

Du, X. H.

Y. Zhang, Q. Wu, M. Zhang, B. W. Song, X. H. Du, and B. Lu, “Evaluating subconjunctival bleb function after trabeculectomy using slit-lamp optical coherence tomography and ultrasound biomicroscopy,” Chin. Med. J. (Engl.) 121(14), 1274–1279 (2008).
[PubMed]

Dupas, B.

A. Labbé, B. Dupas, P. Hamard, and C. Baudouin, “In vivo confocal microscopy study of blebs after filtering surgery,” Ophthalmology 112(11), 1979.e1–1979.e9 (2005).
[CrossRef] [PubMed]

Elsner, A. E.

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci. 49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

Fanjul-Vélez, F.

F. Fanjul-Vélez, M. Pircher, B. Baumann, E. Götzinger, C. K. Hitzenberger, and J. L. Arce-Diego, “Polarimetric analysis of the human cornea measured by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(5), 056004 (2010).
[CrossRef] [PubMed]

Fercher, A. F.

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

Findl, O.

M. Pircher, E. Götzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Human macula investigated in vivo with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5487–5494 (2006).
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Foster, P. J.

M. Singh, P. T. Chew, D. S. Friedman, W. P. Nolan, J. L. See, S. D. Smith, C. Zheng, P. J. Foster, and T. Aung, “Imaging of trabeculectomy blebs using anterior segment optical coherence tomography,” Ophthalmology 114(1), 47–53 (2007).
[CrossRef] [PubMed]

Friedman, D. S.

M. Singh, P. T. Chew, D. S. Friedman, W. P. Nolan, J. L. See, S. D. Smith, C. Zheng, P. J. Foster, and T. Aung, “Imaging of trabeculectomy blebs using anterior segment optical coherence tomography,” Ophthalmology 114(1), 47–53 (2007).
[CrossRef] [PubMed]

Fujimoto, J. G.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Geitzenauer, W.

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Human macula investigated in vivo with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5487–5494 (2006).
[CrossRef] [PubMed]

Goto, H.

Götzinger, E.

F. G. Schlanitz, B. Baumann, T. Spalek, C. Schütze, C. Ahlers, M. Pircher, E. Götzinger, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Performance of automated drusen detection by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 52(7), 4571–4579 (2011).
[CrossRef]

F. Fanjul-Vélez, M. Pircher, B. Baumann, E. Götzinger, C. K. Hitzenberger, and J. L. Arce-Diego, “Polarimetric analysis of the human cornea measured by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(5), 056004 (2010).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, I. Dejaco-Ruhswurm, S. Kaminski, C. Skorpik, and C. K. Hitzenberger, “Imaging of birefringent properties of keratoconus corneas by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(8), 3551–3558 (2007).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, and C. K. Hitzenberger, “Single camera based spectral domain polarization sensitive optical coherence tomography,” Opt. Express 15(3), 1054–1063 (2007).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Human macula investigated in vivo with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5487–5494 (2006).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hamard, P.

A. Labbé, B. Dupas, P. Hamard, and C. Baudouin, “In vivo confocal microscopy study of blebs after filtering surgery,” Ophthalmology 112(11), 1979.e1–1979.e9 (2005).
[CrossRef] [PubMed]

Hee, M. R.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hitzenberger, C. K.

F. G. Schlanitz, B. Baumann, T. Spalek, C. Schütze, C. Ahlers, M. Pircher, E. Götzinger, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Performance of automated drusen detection by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 52(7), 4571–4579 (2011).
[CrossRef]

F. Fanjul-Vélez, M. Pircher, B. Baumann, E. Götzinger, C. K. Hitzenberger, and J. L. Arce-Diego, “Polarimetric analysis of the human cornea measured by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(5), 056004 (2010).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, I. Dejaco-Ruhswurm, S. Kaminski, C. Skorpik, and C. K. Hitzenberger, “Imaging of birefringent properties of keratoconus corneas by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(8), 3551–3558 (2007).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, and C. K. Hitzenberger, “Single camera based spectral domain polarization sensitive optical coherence tomography,” Opt. Express 15(3), 1054–1063 (2007).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Human macula investigated in vivo with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5487–5494 (2006).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

Huang, D.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Iwasaki, T.

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci. 49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

M. Miura, K. Kawana, T. Iwasaki, T. Kiuchi, T. Oshika, H. Mori, M. Yamanari, S. Makita, T. Yatagai, and Y. Yasuno, “Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy,” J. Glaucoma 17(3), 193–196 (2008).
[CrossRef] [PubMed]

Iwaya, K.

Izatt, J. A.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[PubMed]

Jaronski, J. W.

J. W. Jaronski and H. T. Kasprzak, “Linear birefringence measurements of the in vitro human cornea,” Ophthalmic Physiol. Opt. 23(4), 361–369 (2003).
[CrossRef] [PubMed]

Kaminski, S.

E. Götzinger, M. Pircher, I. Dejaco-Ruhswurm, S. Kaminski, C. Skorpik, and C. K. Hitzenberger, “Imaging of birefringent properties of keratoconus corneas by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(8), 3551–3558 (2007).
[CrossRef] [PubMed]

Kasprzak, H. T.

J. W. Jaronski and H. T. Kasprzak, “Linear birefringence measurements of the in vitro human cornea,” Ophthalmic Physiol. Opt. 23(4), 361–369 (2003).
[CrossRef] [PubMed]

Kawana, K.

Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express 17(5), 3980–3996 (2009).
[CrossRef] [PubMed]

K. Kawana, T. Kiuchi, Y. Yasuno, and T. Oshika, “Evaluation of trabeculectomy blebs using 3-dimensional cornea and anterior segment optical coherence tomography,” Ophthalmology 116(5), 848–855 (2009).
[CrossRef] [PubMed]

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express 17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

M. Miura, K. Kawana, T. Iwasaki, T. Kiuchi, T. Oshika, H. Mori, M. Yamanari, S. Makita, T. Yatagai, and Y. Yasuno, “Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy,” J. Glaucoma 17(3), 193–196 (2008).
[CrossRef] [PubMed]

Kiuchi, T.

K. Kawana, T. Kiuchi, Y. Yasuno, and T. Oshika, “Evaluation of trabeculectomy blebs using 3-dimensional cornea and anterior segment optical coherence tomography,” Ophthalmology 116(5), 848–855 (2009).
[CrossRef] [PubMed]

M. Miura, K. Kawana, T. Iwasaki, T. Kiuchi, T. Oshika, H. Mori, M. Yamanari, S. Makita, T. Yatagai, and Y. Yasuno, “Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy,” J. Glaucoma 17(3), 193–196 (2008).
[CrossRef] [PubMed]

Labbé, A.

A. Labbé, B. Dupas, P. Hamard, and C. Baudouin, “In vivo confocal microscopy study of blebs after filtering surgery,” Ophthalmology 112(11), 1979.e1–1979.e9 (2005).
[CrossRef] [PubMed]

Leydolt, C.

M. Pircher, E. Götzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Human macula investigated in vivo with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5487–5494 (2006).
[CrossRef] [PubMed]

Lim, Y.

Lin, C. P.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Lu, B.

Y. Zhang, Q. Wu, M. Zhang, B. W. Song, X. H. Du, and B. Lu, “Evaluating subconjunctival bleb function after trabeculectomy using slit-lamp optical coherence tomography and ultrasound biomicroscopy,” Chin. Med. J. (Engl.) 121(14), 1274–1279 (2008).
[PubMed]

Makita, S.

S. Makita, M. Yamanari, and Y. Yasuno, “Generalized Jones matrix optical coherence tomography: performance and local birefringence imaging,” Opt. Express 18(2), 854–876 (2010).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, Y. Lim, and Y. Yasuno, “Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulation,” Opt. Express 18(13), 13964–13980 (2010).
[CrossRef] [PubMed]

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express 17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci. 49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt. 13(1), 014013 (2008).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express 16(8), 5892–5906 (2008).
[CrossRef] [PubMed]

M. Miura, K. Kawana, T. Iwasaki, T. Kiuchi, T. Oshika, H. Mori, M. Yamanari, S. Makita, T. Yatagai, and Y. Yasuno, “Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy,” J. Glaucoma 17(3), 193–196 (2008).
[CrossRef] [PubMed]

Michels, S.

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Human macula investigated in vivo with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5487–5494 (2006).
[CrossRef] [PubMed]

Milner, T. E.

J. F. de Boer and T. E. Milner, “Review of polarization sensitive optical coherence tomography and Stokes vector determination,” J. Biomed. Opt. 7(3), 359–371 (2002).
[CrossRef] [PubMed]

Miura, M.

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express 17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express 17(5), 3980–3996 (2009).
[CrossRef] [PubMed]

M. Miura, K. Kawana, T. Iwasaki, T. Kiuchi, T. Oshika, H. Mori, M. Yamanari, S. Makita, T. Yatagai, and Y. Yasuno, “Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy,” J. Glaucoma 17(3), 193–196 (2008).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci. 49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt. 13(1), 014013 (2008).
[CrossRef] [PubMed]

Miyazawa, A.

Mori, H.

M. Miura, K. Kawana, T. Iwasaki, T. Kiuchi, T. Oshika, H. Mori, M. Yamanari, S. Makita, T. Yatagai, and Y. Yasuno, “Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy,” J. Glaucoma 17(3), 193–196 (2008).
[CrossRef] [PubMed]

Naylor, E. J.

A. Stanworth and E. J. Naylor, “Polarized light studies of the cornea: I. the isolated cornea,” J. Exp. Biol. 30, 160–163 (1953).

Nolan, W. P.

M. Singh, P. T. Chew, D. S. Friedman, W. P. Nolan, J. L. See, S. D. Smith, C. Zheng, P. J. Foster, and T. Aung, “Imaging of trabeculectomy blebs using anterior segment optical coherence tomography,” Ophthalmology 114(1), 47–53 (2007).
[CrossRef] [PubMed]

Oshika, T.

K. Kawana, T. Kiuchi, Y. Yasuno, and T. Oshika, “Evaluation of trabeculectomy blebs using 3-dimensional cornea and anterior segment optical coherence tomography,” Ophthalmology 116(5), 848–855 (2009).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express 17(5), 3980–3996 (2009).
[CrossRef] [PubMed]

M. Miura, K. Kawana, T. Iwasaki, T. Kiuchi, T. Oshika, H. Mori, M. Yamanari, S. Makita, T. Yatagai, and Y. Yasuno, “Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy,” J. Glaucoma 17(3), 193–196 (2008).
[CrossRef] [PubMed]

Park, B. H.

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

Pierce, M. C.

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

Pircher, M.

F. G. Schlanitz, B. Baumann, T. Spalek, C. Schütze, C. Ahlers, M. Pircher, E. Götzinger, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Performance of automated drusen detection by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 52(7), 4571–4579 (2011).
[CrossRef]

F. Fanjul-Vélez, M. Pircher, B. Baumann, E. Götzinger, C. K. Hitzenberger, and J. L. Arce-Diego, “Polarimetric analysis of the human cornea measured by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(5), 056004 (2010).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, I. Dejaco-Ruhswurm, S. Kaminski, C. Skorpik, and C. K. Hitzenberger, “Imaging of birefringent properties of keratoconus corneas by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(8), 3551–3558 (2007).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, and C. K. Hitzenberger, “Single camera based spectral domain polarization sensitive optical coherence tomography,” Opt. Express 15(3), 1054–1063 (2007).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Human macula investigated in vivo with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5487–5494 (2006).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

Podoleanu, A. G.

A. G. Podoleanu and R. B. Rosen, “Combinations of techniques in imaging the retina with high resolution,” Prog. Retin. Eye Res. 27(4), 464–499 (2008).
[CrossRef]

Puliafito, C. A.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Rosen, R. B.

A. G. Podoleanu and R. B. Rosen, “Combinations of techniques in imaging the retina with high resolution,” Prog. Retin. Eye Res. 27(4), 464–499 (2008).
[CrossRef]

Schlanitz, F. G.

F. G. Schlanitz, B. Baumann, T. Spalek, C. Schütze, C. Ahlers, M. Pircher, E. Götzinger, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Performance of automated drusen detection by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 52(7), 4571–4579 (2011).
[CrossRef]

Schmidt-Erfurth, U.

F. G. Schlanitz, B. Baumann, T. Spalek, C. Schütze, C. Ahlers, M. Pircher, E. Götzinger, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Performance of automated drusen detection by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 52(7), 4571–4579 (2011).
[CrossRef]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Human macula investigated in vivo with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5487–5494 (2006).
[CrossRef] [PubMed]

Schuman, J. S.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Schütze, C.

F. G. Schlanitz, B. Baumann, T. Spalek, C. Schütze, C. Ahlers, M. Pircher, E. Götzinger, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Performance of automated drusen detection by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 52(7), 4571–4579 (2011).
[CrossRef]

See, J. L.

M. Singh, P. T. Chew, D. S. Friedman, W. P. Nolan, J. L. See, S. D. Smith, C. Zheng, P. J. Foster, and T. Aung, “Imaging of trabeculectomy blebs using anterior segment optical coherence tomography,” Ophthalmology 114(1), 47–53 (2007).
[CrossRef] [PubMed]

Singh, M.

M. Singh, P. T. Chew, D. S. Friedman, W. P. Nolan, J. L. See, S. D. Smith, C. Zheng, P. J. Foster, and T. Aung, “Imaging of trabeculectomy blebs using anterior segment optical coherence tomography,” Ophthalmology 114(1), 47–53 (2007).
[CrossRef] [PubMed]

Skorpik, C.

E. Götzinger, M. Pircher, I. Dejaco-Ruhswurm, S. Kaminski, C. Skorpik, and C. K. Hitzenberger, “Imaging of birefringent properties of keratoconus corneas by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(8), 3551–3558 (2007).
[CrossRef] [PubMed]

Smith, S. D.

M. Singh, P. T. Chew, D. S. Friedman, W. P. Nolan, J. L. See, S. D. Smith, C. Zheng, P. J. Foster, and T. Aung, “Imaging of trabeculectomy blebs using anterior segment optical coherence tomography,” Ophthalmology 114(1), 47–53 (2007).
[CrossRef] [PubMed]

Song, B. W.

Y. Zhang, Q. Wu, M. Zhang, B. W. Song, X. H. Du, and B. Lu, “Evaluating subconjunctival bleb function after trabeculectomy using slit-lamp optical coherence tomography and ultrasound biomicroscopy,” Chin. Med. J. (Engl.) 121(14), 1274–1279 (2008).
[PubMed]

Spalek, T.

F. G. Schlanitz, B. Baumann, T. Spalek, C. Schütze, C. Ahlers, M. Pircher, E. Götzinger, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Performance of automated drusen detection by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 52(7), 4571–4579 (2011).
[CrossRef]

Stanworth, A.

A. Stanworth and E. J. Naylor, “Polarized light studies of the cornea: I. the isolated cornea,” J. Exp. Biol. 30, 160–163 (1953).

Sticker, M.

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Swanson, E. A.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Van Blokland, G. J.

Vargas-Martín, F.

Verhelst, S. C.

Wu, Q.

Y. Zhang, Q. Wu, M. Zhang, B. W. Song, X. H. Du, and B. Lu, “Evaluating subconjunctival bleb function after trabeculectomy using slit-lamp optical coherence tomography and ultrasound biomicroscopy,” Chin. Med. J. (Engl.) 121(14), 1274–1279 (2008).
[PubMed]

Yamanari, M.

S. Makita, M. Yamanari, and Y. Yasuno, “Generalized Jones matrix optical coherence tomography: performance and local birefringence imaging,” Opt. Express 18(2), 854–876 (2010).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, Y. Lim, and Y. Yasuno, “Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulation,” Opt. Express 18(13), 13964–13980 (2010).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express 17(5), 3980–3996 (2009).
[CrossRef] [PubMed]

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express 17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci. 49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt. 13(1), 014013 (2008).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express 16(8), 5892–5906 (2008).
[CrossRef] [PubMed]

M. Miura, K. Kawana, T. Iwasaki, T. Kiuchi, T. Oshika, H. Mori, M. Yamanari, S. Makita, T. Yatagai, and Y. Yasuno, “Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy,” J. Glaucoma 17(3), 193–196 (2008).
[CrossRef] [PubMed]

Yasuno, Y.

S. Makita, M. Yamanari, and Y. Yasuno, “Generalized Jones matrix optical coherence tomography: performance and local birefringence imaging,” Opt. Express 18(2), 854–876 (2010).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, Y. Lim, and Y. Yasuno, “Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulation,” Opt. Express 18(13), 13964–13980 (2010).
[CrossRef] [PubMed]

Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express 17(5), 3980–3996 (2009).
[CrossRef] [PubMed]

K. Kawana, T. Kiuchi, Y. Yasuno, and T. Oshika, “Evaluation of trabeculectomy blebs using 3-dimensional cornea and anterior segment optical coherence tomography,” Ophthalmology 116(5), 848–855 (2009).
[CrossRef] [PubMed]

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express 17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci. 49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt. 13(1), 014013 (2008).
[CrossRef] [PubMed]

M. Miura, K. Kawana, T. Iwasaki, T. Kiuchi, T. Oshika, H. Mori, M. Yamanari, S. Makita, T. Yatagai, and Y. Yasuno, “Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy,” J. Glaucoma 17(3), 193–196 (2008).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express 16(8), 5892–5906 (2008).
[CrossRef] [PubMed]

Yatagai, T.

M. Miura, K. Kawana, T. Iwasaki, T. Kiuchi, T. Oshika, H. Mori, M. Yamanari, S. Makita, T. Yatagai, and Y. Yasuno, “Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy,” J. Glaucoma 17(3), 193–196 (2008).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt. 13(1), 014013 (2008).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci. 49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

Zhang, M.

Y. Zhang, Q. Wu, M. Zhang, B. W. Song, X. H. Du, and B. Lu, “Evaluating subconjunctival bleb function after trabeculectomy using slit-lamp optical coherence tomography and ultrasound biomicroscopy,” Chin. Med. J. (Engl.) 121(14), 1274–1279 (2008).
[PubMed]

Zhang, Y.

Y. Zhang, Q. Wu, M. Zhang, B. W. Song, X. H. Du, and B. Lu, “Evaluating subconjunctival bleb function after trabeculectomy using slit-lamp optical coherence tomography and ultrasound biomicroscopy,” Chin. Med. J. (Engl.) 121(14), 1274–1279 (2008).
[PubMed]

Zheng, C.

M. Singh, P. T. Chew, D. S. Friedman, W. P. Nolan, J. L. See, S. D. Smith, C. Zheng, P. J. Foster, and T. Aung, “Imaging of trabeculectomy blebs using anterior segment optical coherence tomography,” Ophthalmology 114(1), 47–53 (2007).
[CrossRef] [PubMed]

Appl. Opt. (2)

Arch. Ophthalmol. (1)

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[PubMed]

Chin. Med. J. (Engl.) (1)

Y. Zhang, Q. Wu, M. Zhang, B. W. Song, X. H. Du, and B. Lu, “Evaluating subconjunctival bleb function after trabeculectomy using slit-lamp optical coherence tomography and ultrasound biomicroscopy,” Chin. Med. J. (Engl.) 121(14), 1274–1279 (2008).
[PubMed]

Invest. Ophthalmol. Vis. Sci. (5)

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Human macula investigated in vivo with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 47(12), 5487–5494 (2006).
[CrossRef] [PubMed]

M. Miura, M. Yamanari, T. Iwasaki, A. E. Elsner, S. Makita, T. Yatagai, and Y. Yasuno, “Imaging polarimetry in age-related macular degeneration,” Invest. Ophthalmol. Vis. Sci. 49(6), 2661–2667 (2008).
[CrossRef] [PubMed]

F. G. Schlanitz, B. Baumann, T. Spalek, C. Schütze, C. Ahlers, M. Pircher, E. Götzinger, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Performance of automated drusen detection by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 52(7), 4571–4579 (2011).
[CrossRef]

E. Götzinger, M. Pircher, I. Dejaco-Ruhswurm, S. Kaminski, C. Skorpik, and C. K. Hitzenberger, “Imaging of birefringent properties of keratoconus corneas by polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 48(8), 3551–3558 (2007).
[CrossRef] [PubMed]

J. Biomed. Opt. (4)

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
[CrossRef] [PubMed]

F. Fanjul-Vélez, M. Pircher, B. Baumann, E. Götzinger, C. K. Hitzenberger, and J. L. Arce-Diego, “Polarimetric analysis of the human cornea measured by polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 15(5), 056004 (2010).
[CrossRef] [PubMed]

J. F. de Boer and T. E. Milner, “Review of polarization sensitive optical coherence tomography and Stokes vector determination,” J. Biomed. Opt. 7(3), 359–371 (2002).
[CrossRef] [PubMed]

M. Yamanari, M. Miura, S. Makita, T. Yatagai, and Y. Yasuno, “Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry,” J. Biomed. Opt. 13(1), 014013 (2008).
[CrossRef] [PubMed]

J. Exp. Biol. (1)

A. Stanworth and E. J. Naylor, “Polarized light studies of the cornea: I. the isolated cornea,” J. Exp. Biol. 30, 160–163 (1953).

J. Glaucoma (1)

M. Miura, K. Kawana, T. Iwasaki, T. Kiuchi, T. Oshika, H. Mori, M. Yamanari, S. Makita, T. Yatagai, and Y. Yasuno, “Three-dimensional anterior segment optical coherence tomography of filtering blebs after trabeculectomy,” J. Glaucoma 17(3), 193–196 (2008).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (1)

Ophthalmic Physiol. Opt. (1)

J. W. Jaronski and H. T. Kasprzak, “Linear birefringence measurements of the in vitro human cornea,” Ophthalmic Physiol. Opt. 23(4), 361–369 (2003).
[CrossRef] [PubMed]

Ophthalmology (3)

A. Labbé, B. Dupas, P. Hamard, and C. Baudouin, “In vivo confocal microscopy study of blebs after filtering surgery,” Ophthalmology 112(11), 1979.e1–1979.e9 (2005).
[CrossRef] [PubMed]

M. Singh, P. T. Chew, D. S. Friedman, W. P. Nolan, J. L. See, S. D. Smith, C. Zheng, P. J. Foster, and T. Aung, “Imaging of trabeculectomy blebs using anterior segment optical coherence tomography,” Ophthalmology 114(1), 47–53 (2007).
[CrossRef] [PubMed]

K. Kawana, T. Kiuchi, Y. Yasuno, and T. Oshika, “Evaluation of trabeculectomy blebs using 3-dimensional cornea and anterior segment optical coherence tomography,” Ophthalmology 116(5), 848–855 (2009).
[CrossRef] [PubMed]

Opt. Express (7)

Y. Yasuno, M. Yamanari, K. Kawana, T. Oshika, and M. Miura, “Investigation of post-glaucoma-surgery structures by three-dimensional and polarization sensitive anterior eye segment optical coherence tomography,” Opt. Express 17(5), 3980–3996 (2009).
[CrossRef] [PubMed]

E. Götzinger, M. Pircher, W. Geitzenauer, C. Ahlers, B. Baumann, S. Michels, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography,” Opt. Express 16(21), 16410–16422 (2008).
[CrossRef] [PubMed]

A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, and Y. Yasuno, “Tissue discrimination in anterior eye using three optical parameters obtained by polarization sensitive optical coherence tomography,” Opt. Express 17(20), 17426–17440 (2009).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express 16(8), 5892–5906 (2008).
[CrossRef] [PubMed]

S. Makita, M. Yamanari, and Y. Yasuno, “Generalized Jones matrix optical coherence tomography: performance and local birefringence imaging,” Opt. Express 18(2), 854–876 (2010).
[CrossRef] [PubMed]

M. Yamanari, S. Makita, Y. Lim, and Y. Yasuno, “Full-range polarization-sensitive swept-source optical coherence tomography by simultaneous transversal and spectral modulation,” Opt. Express 18(13), 13964–13980 (2010).
[CrossRef] [PubMed]

B. Baumann, E. Götzinger, M. Pircher, and C. K. Hitzenberger, “Single camera based spectral domain polarization sensitive optical coherence tomography,” Opt. Express 15(3), 1054–1063 (2007).
[CrossRef] [PubMed]

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A. G. Podoleanu and R. B. Rosen, “Combinations of techniques in imaging the retina with high resolution,” Prog. Retin. Eye Res. 27(4), 464–499 (2008).
[CrossRef]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

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Figures (7)

Fig. 1
Fig. 1

(a) Schematics and (b) picture of PS-OCT. A/D: Digitizer, BS: Beam splitter, EOM: Electro-optic modulator, PBS: Polarization beam splitter, PC: Polarization Controller, PD: Photodetector, PeBS: Pellicle beam splitter. Components within shaded area were packed in a 402 mm × 452 mm standard rack box. All optical components are connected with single mode fibers, except the free space detection arm.

Fig. 2
Fig. 2

Rotation of each element of Jones matrix in a complex plane.

Fig. 3
Fig. 3

(a), (d), (g), (j) Histology images, (b), (e), (h), (k) intensity images, and (c), (f), (i), (l) phase retardation images of rabbit trabeculectomy model. (a)–(c) Control eye. Postoperative day (d)–(f) 0, (g)–(i) 8, and (j)–(l) 14.

Fig. 4
Fig. 4

(left) Scattering OCT and (right) phase retardation images of trabeculectomy cases A–E.

Fig. 5
Fig. 5

(a) Scattering OCT and (b) phase retardation images of a pterygium eye.

Fig. 6
Fig. 6

(left) Intensity images and (right) phase retardation images of (a), (b) a cornea without marked anterior disorder, (c), (d) a cornea with moderate but noticeable thinning keratoconus, (e)–(h) an advanced thinning keratoconus, and (i), (j) a keratoconus with a rupture in the membrane. (g), (h) The posterior surface en face images of the cornea in (e), (f).

Fig. 7
Fig. 7

Intensity images and phase retardation images of keratoplasty patients.

Equations (3)

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J n =   ( a n b n c n d n ) = exp ( i β n ) ( a' n b' n c' n d' n )
β n β 1 = { ( | a 1 | 1 + | a n | 1 ) 1 exp ( i ( θ a n θ a 1 ) ) + ( | b 1 | 1 + | b n | 1 ) 1 exp ( i ( θ b n θ b 1 ) ) + ( | c 1 | 1 + | c n | 1 ) 1 exp ( i ( θ a n θ a 1 ) ) + ( | d 1 | 1 + | d n | 1 ) 1 exp ( i ( θ b n θ b 1 ) ) }
S N R J 1 = ( 1 4 ( S N R a 1 1 + S N R b 1 1 + S N R c 1 1 + S N R d 1 1 ) ) 1

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