Abstract

We designed, fabricated and tested a novel imaging system that fuses diffuse optical tomography (DOT) and photoacoustic tomography (PAT) in a single platform. This platform takes advantages of both DOT and PAT, and can potentially provide dual-modality two dimensional functional and cellular images of the breast quantitatively. Here we describe this integrated platform along with initial tissue phantom validations.

© 2011 OSA

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  1. S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
    [CrossRef] [PubMed]
  2. M. Pramanik, G. Ku, C. H. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008).
    [CrossRef] [PubMed]
  3. G. Ku, B. D. Fornage, X. Jin, M. Xu, K. K. Hunt, and L. V. Wang, “Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging,” Technol. Cancer Res. Treat. 4(5), 559–566 (2005).
    [PubMed]
  4. D. Piras, W. Xia, W. Steenbergen, T. G. Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
    [CrossRef]
  5. S. Manohar, S. E. Vaartjes, J. C. G. van Hespen, J. M. Klaase, F. M. van den Engh, W. Steenbergen, and T. G. van Leeuwen, “Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics,” Opt. Express 15(19), 12277–12285 (2007).
    [CrossRef] [PubMed]
  6. S. Manohar, A. Kharine, J. C. G. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms,” J. Biomed. Opt. 9(6), 1172–1181 (2004).
    [CrossRef] [PubMed]
  7. R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” Med. Phys. 37(11), 6096–6100 (2010).
    [CrossRef] [PubMed]
  8. L. Yao, Y. Sun, and H. Jiang, “Quantitative photoacoustic tomography based on the radiative transfer equation,” Opt. Lett. 34(12), 1765–1767 (2009).
    [CrossRef] [PubMed]
  9. Z. Yuan and H. Jiang, “Quantitative photoacoustic tomography: Recovery of optical absorption coefficient maps of heterogeneous media,” Appl. Phys. Lett. 88(23), 231101 (2006).
    [CrossRef]
  10. B. T. Cox, J. G. Laufer, and P. C. Beard, “The challenges for quantitative photoacoustic imaging,” Proc. SPIE 7177, 717–713 (2009).
  11. C. Li and H. Jiang, “Imaging of particle size and concentration in heterogeneous turbid media with multispectral diffuse optical tomography,” Opt. Express 12(25), 6313–6318 (2004).
    [CrossRef] [PubMed]
  12. H. Jiang, N. V. Iftimia, Y. Xu, J. A. Eggert, L. L. Fajardo, and K. L. Klove, “Near-infrared optical imaging of the breast with model-based reconstruction,” Acad. Radiol. 9(2), 186–194 (2002).
    [CrossRef] [PubMed]
  13. C. Li, H. Zhao, B. Anderson, and H. Jiang, “Multispectral breast imaging using a ten-wavelength, 64 x 64 source/detector channels silicon photodiode-based diffuse optical tomography system,” Med. Phys. 33(3), 627–636 (2006).
    [CrossRef] [PubMed]
  14. H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissue-like phantoms,” Phys. Med. Biol. 43(3), 675–693 (1998).
    [CrossRef] [PubMed]
  15. N. Iftimia and H. Jiang, “Quantitative optical image reconstruction of turbid media by use of direct-current measurements,” Appl. Opt. 39(28), 5256–5261 (2000).
    [CrossRef] [PubMed]
  16. L. Yin, Q. Wang, Q. Zhang, and H. Jiang, “Tomographic imaging of absolute optical absorption coefficient in turbid media using combined photoacoustic and diffusing light measurements,” Opt. Lett. 32(17), 2556–2558 (2007).
    [CrossRef] [PubMed]

2010 (2)

D. Piras, W. Xia, W. Steenbergen, T. G. Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[CrossRef]

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

2009 (3)

L. Yao, Y. Sun, and H. Jiang, “Quantitative photoacoustic tomography based on the radiative transfer equation,” Opt. Lett. 34(12), 1765–1767 (2009).
[CrossRef] [PubMed]

B. T. Cox, J. G. Laufer, and P. C. Beard, “The challenges for quantitative photoacoustic imaging,” Proc. SPIE 7177, 717–713 (2009).

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

2008 (1)

M. Pramanik, G. Ku, C. H. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008).
[CrossRef] [PubMed]

2007 (2)

2006 (2)

C. Li, H. Zhao, B. Anderson, and H. Jiang, “Multispectral breast imaging using a ten-wavelength, 64 x 64 source/detector channels silicon photodiode-based diffuse optical tomography system,” Med. Phys. 33(3), 627–636 (2006).
[CrossRef] [PubMed]

Z. Yuan and H. Jiang, “Quantitative photoacoustic tomography: Recovery of optical absorption coefficient maps of heterogeneous media,” Appl. Phys. Lett. 88(23), 231101 (2006).
[CrossRef]

2005 (1)

G. Ku, B. D. Fornage, X. Jin, M. Xu, K. K. Hunt, and L. V. Wang, “Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging,” Technol. Cancer Res. Treat. 4(5), 559–566 (2005).
[PubMed]

2004 (2)

S. Manohar, A. Kharine, J. C. G. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms,” J. Biomed. Opt. 9(6), 1172–1181 (2004).
[CrossRef] [PubMed]

C. Li and H. Jiang, “Imaging of particle size and concentration in heterogeneous turbid media with multispectral diffuse optical tomography,” Opt. Express 12(25), 6313–6318 (2004).
[CrossRef] [PubMed]

2002 (1)

H. Jiang, N. V. Iftimia, Y. Xu, J. A. Eggert, L. L. Fajardo, and K. L. Klove, “Near-infrared optical imaging of the breast with model-based reconstruction,” Acad. Radiol. 9(2), 186–194 (2002).
[CrossRef] [PubMed]

2000 (1)

1998 (1)

H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissue-like phantoms,” Phys. Med. Biol. 43(3), 675–693 (1998).
[CrossRef] [PubMed]

Anderson, B.

C. Li, H. Zhao, B. Anderson, and H. Jiang, “Multispectral breast imaging using a ten-wavelength, 64 x 64 source/detector channels silicon photodiode-based diffuse optical tomography system,” Med. Phys. 33(3), 627–636 (2006).
[CrossRef] [PubMed]

Beard, P. C.

B. T. Cox, J. G. Laufer, and P. C. Beard, “The challenges for quantitative photoacoustic imaging,” Proc. SPIE 7177, 717–713 (2009).

Conjusteau, A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Cox, B. T.

B. T. Cox, J. G. Laufer, and P. C. Beard, “The challenges for quantitative photoacoustic imaging,” Proc. SPIE 7177, 717–713 (2009).

Del Rio, S. P.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Doyle, R. P.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Eggert, J. A.

H. Jiang, N. V. Iftimia, Y. Xu, J. A. Eggert, L. L. Fajardo, and K. L. Klove, “Near-infrared optical imaging of the breast with model-based reconstruction,” Acad. Radiol. 9(2), 186–194 (2002).
[CrossRef] [PubMed]

Ermilov, S. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Fajardo, L. L.

H. Jiang, N. V. Iftimia, Y. Xu, J. A. Eggert, L. L. Fajardo, and K. L. Klove, “Near-infrared optical imaging of the breast with model-based reconstruction,” Acad. Radiol. 9(2), 186–194 (2002).
[CrossRef] [PubMed]

Fornage, B. D.

G. Ku, B. D. Fornage, X. Jin, M. Xu, K. K. Hunt, and L. V. Wang, “Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging,” Technol. Cancer Res. Treat. 4(5), 559–566 (2005).
[PubMed]

Hunt, K. K.

G. Ku, B. D. Fornage, X. Jin, M. Xu, K. K. Hunt, and L. V. Wang, “Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging,” Technol. Cancer Res. Treat. 4(5), 559–566 (2005).
[PubMed]

Iftimia, N.

Iftimia, N. V.

H. Jiang, N. V. Iftimia, Y. Xu, J. A. Eggert, L. L. Fajardo, and K. L. Klove, “Near-infrared optical imaging of the breast with model-based reconstruction,” Acad. Radiol. 9(2), 186–194 (2002).
[CrossRef] [PubMed]

Jiang, H.

L. Yao, Y. Sun, and H. Jiang, “Quantitative photoacoustic tomography based on the radiative transfer equation,” Opt. Lett. 34(12), 1765–1767 (2009).
[CrossRef] [PubMed]

L. Yin, Q. Wang, Q. Zhang, and H. Jiang, “Tomographic imaging of absolute optical absorption coefficient in turbid media using combined photoacoustic and diffusing light measurements,” Opt. Lett. 32(17), 2556–2558 (2007).
[CrossRef] [PubMed]

Z. Yuan and H. Jiang, “Quantitative photoacoustic tomography: Recovery of optical absorption coefficient maps of heterogeneous media,” Appl. Phys. Lett. 88(23), 231101 (2006).
[CrossRef]

C. Li, H. Zhao, B. Anderson, and H. Jiang, “Multispectral breast imaging using a ten-wavelength, 64 x 64 source/detector channels silicon photodiode-based diffuse optical tomography system,” Med. Phys. 33(3), 627–636 (2006).
[CrossRef] [PubMed]

C. Li and H. Jiang, “Imaging of particle size and concentration in heterogeneous turbid media with multispectral diffuse optical tomography,” Opt. Express 12(25), 6313–6318 (2004).
[CrossRef] [PubMed]

H. Jiang, N. V. Iftimia, Y. Xu, J. A. Eggert, L. L. Fajardo, and K. L. Klove, “Near-infrared optical imaging of the breast with model-based reconstruction,” Acad. Radiol. 9(2), 186–194 (2002).
[CrossRef] [PubMed]

N. Iftimia and H. Jiang, “Quantitative optical image reconstruction of turbid media by use of direct-current measurements,” Appl. Opt. 39(28), 5256–5261 (2000).
[CrossRef] [PubMed]

H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissue-like phantoms,” Phys. Med. Biol. 43(3), 675–693 (1998).
[CrossRef] [PubMed]

Jin, X.

G. Ku, B. D. Fornage, X. Jin, M. Xu, K. K. Hunt, and L. V. Wang, “Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging,” Technol. Cancer Res. Treat. 4(5), 559–566 (2005).
[PubMed]

Khamapirad, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Kharine, A.

S. Manohar, A. Kharine, J. C. G. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms,” J. Biomed. Opt. 9(6), 1172–1181 (2004).
[CrossRef] [PubMed]

Klaase, J. M.

Klove, K. L.

H. Jiang, N. V. Iftimia, Y. Xu, J. A. Eggert, L. L. Fajardo, and K. L. Klove, “Near-infrared optical imaging of the breast with model-based reconstruction,” Acad. Radiol. 9(2), 186–194 (2002).
[CrossRef] [PubMed]

Kruger, R. A.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Ku, G.

M. Pramanik, G. Ku, C. H. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008).
[CrossRef] [PubMed]

G. Ku, B. D. Fornage, X. Jin, M. Xu, K. K. Hunt, and L. V. Wang, “Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging,” Technol. Cancer Res. Treat. 4(5), 559–566 (2005).
[PubMed]

Lacewell, R.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Lam, R. B.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Laufer, J. G.

B. T. Cox, J. G. Laufer, and P. C. Beard, “The challenges for quantitative photoacoustic imaging,” Proc. SPIE 7177, 717–713 (2009).

Leeuwen, T. G.

D. Piras, W. Xia, W. Steenbergen, T. G. Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[CrossRef]

Leonard, M. H.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Li, C.

C. Li, H. Zhao, B. Anderson, and H. Jiang, “Multispectral breast imaging using a ten-wavelength, 64 x 64 source/detector channels silicon photodiode-based diffuse optical tomography system,” Med. Phys. 33(3), 627–636 (2006).
[CrossRef] [PubMed]

C. Li and H. Jiang, “Imaging of particle size and concentration in heterogeneous turbid media with multispectral diffuse optical tomography,” Opt. Express 12(25), 6313–6318 (2004).
[CrossRef] [PubMed]

Li, C. H.

M. Pramanik, G. Ku, C. H. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008).
[CrossRef] [PubMed]

Manohar, S.

D. Piras, W. Xia, W. Steenbergen, T. G. Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[CrossRef]

S. Manohar, S. E. Vaartjes, J. C. G. van Hespen, J. M. Klaase, F. M. van den Engh, W. Steenbergen, and T. G. van Leeuwen, “Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics,” Opt. Express 15(19), 12277–12285 (2007).
[CrossRef] [PubMed]

S. Manohar, A. Kharine, J. C. G. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms,” J. Biomed. Opt. 9(6), 1172–1181 (2004).
[CrossRef] [PubMed]

Mehta, K.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Miller, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Oraevsky, A. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Osterberg, U. L.

H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissue-like phantoms,” Phys. Med. Biol. 43(3), 675–693 (1998).
[CrossRef] [PubMed]

Patterson, M. S.

H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissue-like phantoms,” Phys. Med. Biol. 43(3), 675–693 (1998).
[CrossRef] [PubMed]

Paulsen, K. D.

H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissue-like phantoms,” Phys. Med. Biol. 43(3), 675–693 (1998).
[CrossRef] [PubMed]

Piras, D.

D. Piras, W. Xia, W. Steenbergen, T. G. Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[CrossRef]

Pramanik, M.

M. Pramanik, G. Ku, C. H. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008).
[CrossRef] [PubMed]

Reinecke, D. R.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Steenbergen, W.

D. Piras, W. Xia, W. Steenbergen, T. G. Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[CrossRef]

S. Manohar, S. E. Vaartjes, J. C. G. van Hespen, J. M. Klaase, F. M. van den Engh, W. Steenbergen, and T. G. van Leeuwen, “Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics,” Opt. Express 15(19), 12277–12285 (2007).
[CrossRef] [PubMed]

S. Manohar, A. Kharine, J. C. G. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms,” J. Biomed. Opt. 9(6), 1172–1181 (2004).
[CrossRef] [PubMed]

Sun, Y.

Vaartjes, S. E.

van den Engh, F. M.

van Hespen, J. C. G.

S. Manohar, S. E. Vaartjes, J. C. G. van Hespen, J. M. Klaase, F. M. van den Engh, W. Steenbergen, and T. G. van Leeuwen, “Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics,” Opt. Express 15(19), 12277–12285 (2007).
[CrossRef] [PubMed]

S. Manohar, A. Kharine, J. C. G. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms,” J. Biomed. Opt. 9(6), 1172–1181 (2004).
[CrossRef] [PubMed]

van Leeuwen, T. G.

S. Manohar, S. E. Vaartjes, J. C. G. van Hespen, J. M. Klaase, F. M. van den Engh, W. Steenbergen, and T. G. van Leeuwen, “Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics,” Opt. Express 15(19), 12277–12285 (2007).
[CrossRef] [PubMed]

S. Manohar, A. Kharine, J. C. G. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms,” J. Biomed. Opt. 9(6), 1172–1181 (2004).
[CrossRef] [PubMed]

Wang, L. V.

M. Pramanik, G. Ku, C. H. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008).
[CrossRef] [PubMed]

G. Ku, B. D. Fornage, X. Jin, M. Xu, K. K. Hunt, and L. V. Wang, “Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging,” Technol. Cancer Res. Treat. 4(5), 559–566 (2005).
[PubMed]

Wang, Q.

Xia, W.

D. Piras, W. Xia, W. Steenbergen, T. G. Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[CrossRef]

Xu, M.

G. Ku, B. D. Fornage, X. Jin, M. Xu, K. K. Hunt, and L. V. Wang, “Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging,” Technol. Cancer Res. Treat. 4(5), 559–566 (2005).
[PubMed]

Xu, Y.

H. Jiang, N. V. Iftimia, Y. Xu, J. A. Eggert, L. L. Fajardo, and K. L. Klove, “Near-infrared optical imaging of the breast with model-based reconstruction,” Acad. Radiol. 9(2), 186–194 (2002).
[CrossRef] [PubMed]

Yao, L.

Yin, L.

Yuan, Z.

Z. Yuan and H. Jiang, “Quantitative photoacoustic tomography: Recovery of optical absorption coefficient maps of heterogeneous media,” Appl. Phys. Lett. 88(23), 231101 (2006).
[CrossRef]

Zhang, Q.

Zhao, H.

C. Li, H. Zhao, B. Anderson, and H. Jiang, “Multispectral breast imaging using a ten-wavelength, 64 x 64 source/detector channels silicon photodiode-based diffuse optical tomography system,” Med. Phys. 33(3), 627–636 (2006).
[CrossRef] [PubMed]

Acad. Radiol. (1)

H. Jiang, N. V. Iftimia, Y. Xu, J. A. Eggert, L. L. Fajardo, and K. L. Klove, “Near-infrared optical imaging of the breast with model-based reconstruction,” Acad. Radiol. 9(2), 186–194 (2002).
[CrossRef] [PubMed]

Appl. Opt. (1)

Appl. Phys. Lett. (1)

Z. Yuan and H. Jiang, “Quantitative photoacoustic tomography: Recovery of optical absorption coefficient maps of heterogeneous media,” Appl. Phys. Lett. 88(23), 231101 (2006).
[CrossRef]

IEEE J. Sel. Top. Quantum Electron. (1)

D. Piras, W. Xia, W. Steenbergen, T. G. Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[CrossRef]

J. Biomed. Opt. (2)

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

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Figures (4)

Fig. 1
Fig. 1

(a) Schematic of the integrated PAT/DOT system. (b) Photograph of PAT/DOT probe: 1-PVDF transducers; 2-Source/detector optic fibers. (c) Photograph of PAT/DOT probe with the phantom.

Fig. 2
Fig. 2

Phantom geometry. R1 = 35mm, R2 = 3mm and d = 10mm.

Fig. 3
Fig. 3

Reconstructed absorption coefficient images and profiles through the transect from PAT and DOT. (a) and (b): Case 1 from PAT; (c) and (d): Case 1 from DOT; (e) and (f): Case 2 from PAT; (g) and (h): Case 2 from DOT; (i) and (j): Case 3 from PAT; (k) and (l): Case 3 from DOT.

Fig. 4
Fig. 4

Reconstructed reduced scattering coefficient images and profiles through the transect from DOT. (a) and (b): Case 2, (c) and (d): Case 3.

Tables (2)

Tables Icon

Table 1 Exact Values of Absorption and Reduced Scattering Coefficients (mm−1) of the Target and Background for the Phantom Experiments

Tables Icon

Table 2 Reconstructed Values of Absorption and Reduced Scattering Coefficients (mm−1) of the Target and Background and Target Location (Off-Center) and Size (mm) for the Phantom Experiments*

Metrics