Abstract

A primary focus of neurointensive care is the prevention of secondary brain injury, mainly caused by ischemia. A noninvasive bedside technique for continuous monitoring of cerebral blood flow (CBF) could improve patient management by detecting ischemia before brain injury occurs. A promising technique for this purpose is diffuse correlation spectroscopy (DCS) since it can continuously monitor relative perfusion changes in deep tissue. In this study, DCS was combined with a time-resolved near-infrared technique (TR-NIR) that can directly measure CBF using indocyanine green as a flow tracer. With this combination, the TR-NIR technique can be used to convert DCS data into absolute CBF measurements. The agreement between the two techniques was assessed by concurrent measurements of CBF changes in piglets. A strong correlation between CBF changes measured by TR-NIR and changes in the scaled diffusion coefficient measured by DCS was observed (R2 = 0.93) with a slope of 1.05 ± 0.06 and an intercept of 6.4 ± 4.3% (mean ± standard error).

© 2011 OSA

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
    [CrossRef] [PubMed]
  2. D. A. Boas and A. G. Yodh, “Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation,” J. Opt. Soc. Am. A 14(1), 192–215 (1997).
    [CrossRef]
  3. G. Dietsche, M. Ninck, C. Ortolf, J. Li, F. Jaillon, and T. Gisler, “Fiber-based multispeckle detection for time-resolved diffusing-wave spectroscopy: characterization and application to blood flow detection in deep tissue,” Appl. Opt. 46(35), 8506–8514 (2007).
    [CrossRef] [PubMed]
  4. J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt. 10(4), 044002 (2005).
    [CrossRef] [PubMed]
  5. J. Li, F. Jaillon, G. Dietsche, G. Maret, and T. Gisler, “Pulsation-resolved deep tissue dynamics measured with diffusing-wave spectroscopy,” Opt. Express 14(17), 7841–7851 (2006).
    [CrossRef] [PubMed]
  6. J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, “Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy,” Opt. Lett. 33(19), 2233–2235 (2008).
    [CrossRef] [PubMed]
  7. F. Jaillon, J. Li, G. Dietsche, T. Elbert, and T. Gisler, “Activity of the human visual cortex measured non-invasively by diffusing-wave spectroscopy,” Opt. Express 15(11), 6643–6650 (2007).
    [CrossRef] [PubMed]
  8. M. Ninck, M. Untenberger, and T. Gisler, “Diffusing-wave spectroscopy with dynamic contrast variation: disentangling the effects of blood flow and extravascular tissue shearing on signals from deep tissue,” Biomed. Opt. Express 1(5), 1502–1513 (2010).
    [CrossRef] [PubMed]
  9. M. Belau, M. Ninck, G. Hering, L. Spinelli, D. Contini, A. Torricelli, and T. Gisler, “Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy,” J. Biomed. Opt. 15(5), 057007 (2010).
    [CrossRef] [PubMed]
  10. F. Jaillon, S. E. Skipetrov, J. Li, G. Dietsche, G. Maret, and T. Gisler, “Diffusing-wave spectroscopy from head-like tissue phantoms: influence of a non-scattering layer,” Opt. Express 14(22), 10181–10194 (2006).
    [CrossRef] [PubMed]
  11. E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
    [CrossRef] [PubMed]
  12. C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
    [CrossRef] [PubMed]
  13. G. Yu, T. Durduran, G. Lech, C. Zhou, B. Chance, E. R. Mohler, and A. G. Yodh, “Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 10(2), 024027 (2005).
    [CrossRef] [PubMed]
  14. G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
    [CrossRef] [PubMed]
  15. C. Zhou, “In-vivo optical imaging and spectroscopy of cerebral hemodynamics,” Ph.D. thesis (University of Pennsylvania, 2007).
  16. C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
    [CrossRef] [PubMed]
  17. C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
    [CrossRef] [PubMed]
  18. S. A. Carp, G. P. Dai, D. A. Boas, M. A. Franceschini, and Y. R. Kim, “Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring,” Biomed. Opt. Express 1(2), 553–565 (2010).
    [CrossRef] [PubMed]
  19. J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
    [CrossRef] [PubMed]
  20. T. Durduran, “Non-invasive measurements of tissue hemodynamics with hybrid diffuse optical methods,” Ph.D. thesis (University of Pennsylvania, 2004).
  21. T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, “Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry,” J. Cereb. Blood Flow Metab. 24(5), 518–525 (2004).
    [CrossRef] [PubMed]
  22. T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30(21), 2915–2917 (2005).
    [CrossRef] [PubMed]
  23. T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
    [CrossRef] [PubMed]
  24. T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
    [CrossRef] [PubMed]
  25. T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
    [CrossRef] [PubMed]
  26. L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
    [CrossRef] [PubMed]
  27. C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
    [CrossRef] [PubMed]
  28. C. Zhou, G. Yu, D. Furuya, J. Greenberg, A. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14(3), 1125–1144 (2006).
    [CrossRef] [PubMed]
  29. P. Zirak, R. Delgado-Mederos, J. Martí-Fàbregas, and T. Durduran, “Effects of acetazolamide on the micro- and macro-vascular cerebral hemodynamics: a diffuse optical and transcranial doppler ultrasound study,” Biomed. Opt. Express 1(5), 1443–1459 (2010).
    [CrossRef] [PubMed]
  30. R. C. Mesquita, N. Skuli, M. N. Kim, J. Liang, S. Schenkel, A. J. Majmundar, M. C. Simon, and A. G. Yodh, “Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia,” Biomed. Opt. Express 1(4), 1173–1187 (2010).
    [CrossRef] [PubMed]
  31. T. L. Becker, A. D. Paquette, K. R. Keymel, B. W. Henderson, and U. Sunar, “Monitoring blood flow responses during topical ALA-PDT,” Biomed. Opt. Express 2(1), 123–130 (2011).
    [CrossRef] [PubMed]
  32. M. A. De Georgia and A. Deogaonkar, “Multimodal monitoring in the neurological intensive care unit,” Neurologist 11(1), 45–54 (2005).
    [CrossRef] [PubMed]
  33. CDC, “Traumatic brain injury in the United States: Assessing outcomes in children,” (2000) accessed July 28, 2009, http://www.cdc.gov/ncipc/tbi/tbi_report/09_Appendix_B.htm .
  34. A. Helmy, M. Vizcaychipi, and A. K. Gupta, “Traumatic brain injury: intensive care management,” Br. J. Anaesth. 99(1), 32–42 (2007).
    [CrossRef] [PubMed]
  35. D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res. 51(5), 564–570 (2002).
    [CrossRef] [PubMed]
  36. M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum. 80(5), 054302 (2009).
    [CrossRef] [PubMed]
  37. J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt. 15(3), 037014 (2010).
    [CrossRef] [PubMed]
  38. M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets,” J. Biomed. Opt. 15(5), 057004 (2010).
    [CrossRef] [PubMed]
  39. M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow,” Proc. SPIE 7555, 75550Z (2010).
    [CrossRef]
  40. A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Möller, R. Macdonald, A. Villringer, and H. Rinneberg, “Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons,” Appl. Opt. 43(15), 3037–3047 (2004).
    [CrossRef] [PubMed]
  41. L. Gagnon, C. Gauthier, R. D. Hoge, F. Lesage, J. Selb, and D. A. Boas, “Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system,” J. Biomed. Opt. 13(5), 054019 (2008).
    [CrossRef] [PubMed]
  42. A. Kienle and M. S. Patterson, “Improved solutions of the steady-state and the time-resolved diffusion equations for reflectance from a semi-infinite turbid medium,” J. Opt. Soc. Am. A 14(1), 246–254 (1997).
    [CrossRef] [PubMed]
  43. T.-Y. Lee, “Functional CT: physiological models,” Trends Biotechnol. 20(8), S3–S10 (2002).
    [CrossRef] [PubMed]
  44. A. Cenic, D. G. Nabavi, R. A. Craen, A. W. Gelb, and T.-Y. Lee, “Dynamic CT measurement of cerebral blood flow: a validation study,” AJNR Am. J. Neuroradiol. 20(1), 63–73 (1999).
    [PubMed]
  45. A. Liebert, H. Wabnitz, D. Grosenick, and R. Macdonald, “Fiber dispersion in time domain measurements compromising the accuracy of determination of optical properties of strongly scattering media,” J. Biomed. Opt. 8(3), 512–516 (2003).
    [CrossRef] [PubMed]
  46. S. Prahl, “Optical Absorption of Indocyanine Green (ICG),” http://omlc.ogi.edu/spectra/icg/index.html.
  47. T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
    [CrossRef]
  48. T. Gisler, H. Rüger, S. U. Egelhaaf, J. Tschumi, P. Schurtenberger, and J. Rička, “Mode-selective dynamic light scattering: theory versus experimental realization,” Appl. Opt. 34(18), 3546–3553 (1995).
    [CrossRef] [PubMed]
  49. T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
    [CrossRef] [PubMed]
  50. N. Roche-Labarbe, S. A. Carp, A. Surova, M. Patel, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates’ brains in the first six weeks of life,” Hum. Brain Mapp. 31(3), 341–352 (2010).
    [CrossRef] [PubMed]
  51. M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
    [CrossRef] [PubMed]
  52. I. G. Roberts, P. Fallon, F. J. Kirkham, P. M. Kirshbom, C. E. Cooper, M. J. Elliott, and A. D. Edwards, “Measurement of cerebral blood flow during cardiopulmonary bypass with near-infrared spectroscopy,” J. Thorac. Cardiovasc. Surg. 115(1), 94–102 (1998).
    [CrossRef] [PubMed]
  53. F. Gora, S. Shinde, C. E. Elwell, J. C. Goldstone, M. Cope, D. T. Delpy, and M. Smith, “Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: a pilot study,” J. Neurosurg. Anesthesiol. 14(3), 218–222 (2002).
    [CrossRef] [PubMed]
  54. R. L. Grubb, M. E. Raichle, J. O. Eichling, and M. M. Ter-Pogossian, “The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time,” Stroke 5(5), 630–639 (1974).
    [CrossRef] [PubMed]
  55. B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
    [CrossRef] [PubMed]

2011

2010

P. Zirak, R. Delgado-Mederos, J. Martí-Fàbregas, and T. Durduran, “Effects of acetazolamide on the micro- and macro-vascular cerebral hemodynamics: a diffuse optical and transcranial doppler ultrasound study,” Biomed. Opt. Express 1(5), 1443–1459 (2010).
[CrossRef] [PubMed]

R. C. Mesquita, N. Skuli, M. N. Kim, J. Liang, S. Schenkel, A. J. Majmundar, M. C. Simon, and A. G. Yodh, “Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia,” Biomed. Opt. Express 1(4), 1173–1187 (2010).
[CrossRef] [PubMed]

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt. 15(3), 037014 (2010).
[CrossRef] [PubMed]

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets,” J. Biomed. Opt. 15(5), 057004 (2010).
[CrossRef] [PubMed]

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow,” Proc. SPIE 7555, 75550Z (2010).
[CrossRef]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

M. Ninck, M. Untenberger, and T. Gisler, “Diffusing-wave spectroscopy with dynamic contrast variation: disentangling the effects of blood flow and extravascular tissue shearing on signals from deep tissue,” Biomed. Opt. Express 1(5), 1502–1513 (2010).
[CrossRef] [PubMed]

M. Belau, M. Ninck, G. Hering, L. Spinelli, D. Contini, A. Torricelli, and T. Gisler, “Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy,” J. Biomed. Opt. 15(5), 057007 (2010).
[CrossRef] [PubMed]

S. A. Carp, G. P. Dai, D. A. Boas, M. A. Franceschini, and Y. R. Kim, “Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring,” Biomed. Opt. Express 1(2), 553–565 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

N. Roche-Labarbe, S. A. Carp, A. Surova, M. Patel, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates’ brains in the first six weeks of life,” Hum. Brain Mapp. 31(3), 341–352 (2010).
[CrossRef] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[CrossRef]

2009

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum. 80(5), 054302 (2009).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

2008

L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
[CrossRef] [PubMed]

C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
[CrossRef] [PubMed]

J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, “Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy,” Opt. Lett. 33(19), 2233–2235 (2008).
[CrossRef] [PubMed]

L. Gagnon, C. Gauthier, R. D. Hoge, F. Lesage, J. Selb, and D. A. Boas, “Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system,” J. Biomed. Opt. 13(5), 054019 (2008).
[CrossRef] [PubMed]

2007

2006

2005

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30(21), 2915–2917 (2005).
[CrossRef] [PubMed]

M. A. De Georgia and A. Deogaonkar, “Multimodal monitoring in the neurological intensive care unit,” Neurologist 11(1), 45–54 (2005).
[CrossRef] [PubMed]

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt. 10(4), 044002 (2005).
[CrossRef] [PubMed]

G. Yu, T. Durduran, G. Lech, C. Zhou, B. Chance, E. R. Mohler, and A. G. Yodh, “Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 10(2), 024027 (2005).
[CrossRef] [PubMed]

2004

2003

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

A. Liebert, H. Wabnitz, D. Grosenick, and R. Macdonald, “Fiber dispersion in time domain measurements compromising the accuracy of determination of optical properties of strongly scattering media,” J. Biomed. Opt. 8(3), 512–516 (2003).
[CrossRef] [PubMed]

2002

T.-Y. Lee, “Functional CT: physiological models,” Trends Biotechnol. 20(8), S3–S10 (2002).
[CrossRef] [PubMed]

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res. 51(5), 564–570 (2002).
[CrossRef] [PubMed]

F. Gora, S. Shinde, C. E. Elwell, J. C. Goldstone, M. Cope, D. T. Delpy, and M. Smith, “Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: a pilot study,” J. Neurosurg. Anesthesiol. 14(3), 218–222 (2002).
[CrossRef] [PubMed]

2001

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

1999

A. Cenic, D. G. Nabavi, R. A. Craen, A. W. Gelb, and T.-Y. Lee, “Dynamic CT measurement of cerebral blood flow: a validation study,” AJNR Am. J. Neuroradiol. 20(1), 63–73 (1999).
[PubMed]

1998

I. G. Roberts, P. Fallon, F. J. Kirkham, P. M. Kirshbom, C. E. Cooper, M. J. Elliott, and A. D. Edwards, “Measurement of cerebral blood flow during cardiopulmonary bypass with near-infrared spectroscopy,” J. Thorac. Cardiovasc. Surg. 115(1), 94–102 (1998).
[CrossRef] [PubMed]

1997

1995

1974

R. L. Grubb, M. E. Raichle, J. O. Eichling, and M. M. Ter-Pogossian, “The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time,” Stroke 5(5), 630–639 (1974).
[CrossRef] [PubMed]

Arger, P. H.

Aviv, R. I.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Baker, W. B.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[CrossRef]

Becker, T. L.

Belau, M.

M. Belau, M. Ninck, G. Hering, L. Spinelli, D. Contini, A. Torricelli, and T. Gisler, “Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy,” J. Biomed. Opt. 15(5), 057007 (2010).
[CrossRef] [PubMed]

Beletsky, V.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Bherer, L.

Black, S. E.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Boas, D. A.

N. Roche-Labarbe, S. A. Carp, A. Surova, M. Patel, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates’ brains in the first six weeks of life,” Hum. Brain Mapp. 31(3), 341–352 (2010).
[CrossRef] [PubMed]

S. A. Carp, G. P. Dai, D. A. Boas, M. A. Franceschini, and Y. R. Kim, “Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring,” Biomed. Opt. Express 1(2), 553–565 (2010).
[CrossRef] [PubMed]

L. Gagnon, C. Gauthier, R. D. Hoge, F. Lesage, J. Selb, and D. A. Boas, “Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system,” J. Biomed. Opt. 13(5), 054019 (2008).
[CrossRef] [PubMed]

D. A. Boas and A. G. Yodh, “Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation,” J. Opt. Soc. Am. A 14(1), 192–215 (1997).
[CrossRef]

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef] [PubMed]

Brown, D. W.

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res. 51(5), 564–570 (2002).
[CrossRef] [PubMed]

Buckley, E. M.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

Burnett, M. G.

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, “Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry,” J. Cereb. Blood Flow Metab. 24(5), 518–525 (2004).
[CrossRef] [PubMed]

Butler, J.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Campbell, L. E.

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef] [PubMed]

Carp, S. A.

S. A. Carp, G. P. Dai, D. A. Boas, M. A. Franceschini, and Y. R. Kim, “Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring,” Biomed. Opt. Express 1(2), 553–565 (2010).
[CrossRef] [PubMed]

N. Roche-Labarbe, S. A. Carp, A. Surova, M. Patel, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates’ brains in the first six weeks of life,” Hum. Brain Mapp. 31(3), 341–352 (2010).
[CrossRef] [PubMed]

Cenic, A.

A. Cenic, D. G. Nabavi, R. A. Craen, A. W. Gelb, and T.-Y. Lee, “Dynamic CT measurement of cerebral blood flow: a validation study,” AJNR Am. J. Neuroradiol. 20(1), 63–73 (1999).
[PubMed]

Cerussi, A.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Chan, R.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Chance, B.

G. Yu, T. Durduran, G. Lech, C. Zhou, B. Chance, E. R. Mohler, and A. G. Yodh, “Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 10(2), 024027 (2005).
[CrossRef] [PubMed]

Chen, X. H.

C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
[CrossRef] [PubMed]

Cheung, C.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

Choe, R.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[CrossRef]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30(21), 2915–2917 (2005).
[CrossRef] [PubMed]

Contini, D.

M. Belau, M. Ninck, G. Hering, L. Spinelli, D. Contini, A. Torricelli, and T. Gisler, “Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy,” J. Biomed. Opt. 15(5), 057007 (2010).
[CrossRef] [PubMed]

Cook, N. M.

Cooper, C. E.

I. G. Roberts, P. Fallon, F. J. Kirkham, P. M. Kirshbom, C. E. Cooper, M. J. Elliott, and A. D. Edwards, “Measurement of cerebral blood flow during cardiopulmonary bypass with near-infrared spectroscopy,” J. Thorac. Cardiovasc. Surg. 115(1), 94–102 (1998).
[CrossRef] [PubMed]

Cope, M.

F. Gora, S. Shinde, C. E. Elwell, J. C. Goldstone, M. Cope, D. T. Delpy, and M. Smith, “Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: a pilot study,” J. Neurosurg. Anesthesiol. 14(3), 218–222 (2002).
[CrossRef] [PubMed]

Coutts, S. B.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Craen, R. A.

A. Cenic, D. G. Nabavi, R. A. Craen, A. W. Gelb, and T.-Y. Lee, “Dynamic CT measurement of cerebral blood flow: a validation study,” AJNR Am. J. Neuroradiol. 20(1), 63–73 (1999).
[PubMed]

Cucchiara, B. L.

Culver, J. P.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

Czerniecki, B. J.

Dai, G. P.

De Georgia, M. A.

M. A. De Georgia and A. Deogaonkar, “Multimodal monitoring in the neurological intensive care unit,” Neurologist 11(1), 45–54 (2005).
[CrossRef] [PubMed]

Delgado-Mederos, R.

Delpy, D. T.

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res. 51(5), 564–570 (2002).
[CrossRef] [PubMed]

F. Gora, S. Shinde, C. E. Elwell, J. C. Goldstone, M. Cope, D. T. Delpy, and M. Smith, “Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: a pilot study,” J. Neurosurg. Anesthesiol. 14(3), 218–222 (2002).
[CrossRef] [PubMed]

Demchuk, A. M.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Deogaonkar, A.

M. A. De Georgia and A. Deogaonkar, “Multimodal monitoring in the neurological intensive care unit,” Neurologist 11(1), 45–54 (2005).
[CrossRef] [PubMed]

Desjardins, M.

Detre, J. A.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef] [PubMed]

C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
[CrossRef] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[CrossRef] [PubMed]

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, “Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry,” J. Cereb. Blood Flow Metab. 24(5), 518–525 (2004).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

Dietsche, G.

Diop, M.

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt. 15(3), 037014 (2010).
[CrossRef] [PubMed]

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets,” J. Biomed. Opt. 15(5), 057004 (2010).
[CrossRef] [PubMed]

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow,” Proc. SPIE 7555, 75550Z (2010).
[CrossRef]

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum. 80(5), 054302 (2009).
[CrossRef] [PubMed]

Durduran, T.

P. Zirak, R. Delgado-Mederos, J. Martí-Fàbregas, and T. Durduran, “Effects of acetazolamide on the micro- and macro-vascular cerebral hemodynamics: a diffuse optical and transcranial doppler ultrasound study,” Biomed. Opt. Express 1(5), 1443–1459 (2010).
[CrossRef] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[CrossRef]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef] [PubMed]

C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
[CrossRef] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[CrossRef] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

C. Zhou, G. Yu, D. Furuya, J. Greenberg, A. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14(3), 1125–1144 (2006).
[CrossRef] [PubMed]

G. Yu, T. Durduran, G. Lech, C. Zhou, B. Chance, E. R. Mohler, and A. G. Yodh, “Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 10(2), 024027 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30(21), 2915–2917 (2005).
[CrossRef] [PubMed]

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, “Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry,” J. Cereb. Blood Flow Metab. 24(5), 518–525 (2004).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

Durkin, A.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Durning, S. M.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

Edlow, B. L.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef] [PubMed]

Edwards, A. D.

I. G. Roberts, P. Fallon, F. J. Kirkham, P. M. Kirshbom, C. E. Cooper, M. J. Elliott, and A. D. Edwards, “Measurement of cerebral blood flow during cardiopulmonary bypass with near-infrared spectroscopy,” J. Thorac. Cardiovasc. Surg. 115(1), 94–102 (1998).
[CrossRef] [PubMed]

Egelhaaf, S. U.

Eichling, J. O.

R. L. Grubb, M. E. Raichle, J. O. Eichling, and M. M. Ter-Pogossian, “The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time,” Stroke 5(5), 630–639 (1974).
[CrossRef] [PubMed]

Elbert, T.

Elliott, J. T.

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow,” Proc. SPIE 7555, 75550Z (2010).
[CrossRef]

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets,” J. Biomed. Opt. 15(5), 057004 (2010).
[CrossRef] [PubMed]

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt. 15(3), 037014 (2010).
[CrossRef] [PubMed]

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum. 80(5), 054302 (2009).
[CrossRef] [PubMed]

Elliott, M. J.

I. G. Roberts, P. Fallon, F. J. Kirkham, P. M. Kirshbom, C. E. Cooper, M. J. Elliott, and A. D. Edwards, “Measurement of cerebral blood flow during cardiopulmonary bypass with near-infrared spectroscopy,” J. Thorac. Cardiovasc. Surg. 115(1), 94–102 (1998).
[CrossRef] [PubMed]

Elwell, C. E.

F. Gora, S. Shinde, C. E. Elwell, J. C. Goldstone, M. Cope, D. T. Delpy, and M. Smith, “Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: a pilot study,” J. Neurosurg. Anesthesiol. 14(3), 218–222 (2002).
[CrossRef] [PubMed]

Eucker, S. A.

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

Fallon, P.

I. G. Roberts, P. Fallon, F. J. Kirkham, P. M. Kirshbom, C. E. Cooper, M. J. Elliott, and A. D. Edwards, “Measurement of cerebral blood flow during cardiopulmonary bypass with near-infrared spectroscopy,” J. Thorac. Cardiovasc. Surg. 115(1), 94–102 (1998).
[CrossRef] [PubMed]

Floyd, T. F.

Fox, A. J.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Franceschini, M. A.

N. Roche-Labarbe, S. A. Carp, A. Surova, M. Patel, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates’ brains in the first six weeks of life,” Hum. Brain Mapp. 31(3), 341–352 (2010).
[CrossRef] [PubMed]

S. A. Carp, G. P. Dai, D. A. Boas, M. A. Franceschini, and Y. R. Kim, “Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring,” Biomed. Opt. Express 1(2), 553–565 (2010).
[CrossRef] [PubMed]

Frangos, S.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Friess, S. H.

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

Furuya, D.

C. Zhou, G. Yu, D. Furuya, J. Greenberg, A. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14(3), 1125–1144 (2006).
[CrossRef] [PubMed]

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, “Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry,” J. Cereb. Blood Flow Metab. 24(5), 518–525 (2004).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

Gagnon, L.

L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
[CrossRef] [PubMed]

L. Gagnon, C. Gauthier, R. D. Hoge, F. Lesage, J. Selb, and D. A. Boas, “Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system,” J. Biomed. Opt. 13(5), 054019 (2008).
[CrossRef] [PubMed]

Gauthier, C.

L. Gagnon, C. Gauthier, R. D. Hoge, F. Lesage, J. Selb, and D. A. Boas, “Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system,” J. Biomed. Opt. 13(5), 054019 (2008).
[CrossRef] [PubMed]

Gaynor, J. W.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

Gelb, A. W.

A. Cenic, D. G. Nabavi, R. A. Craen, A. W. Gelb, and T.-Y. Lee, “Dynamic CT measurement of cerebral blood flow: a validation study,” AJNR Am. J. Neuroradiol. 20(1), 63–73 (1999).
[PubMed]

Gisler, T.

M. Ninck, M. Untenberger, and T. Gisler, “Diffusing-wave spectroscopy with dynamic contrast variation: disentangling the effects of blood flow and extravascular tissue shearing on signals from deep tissue,” Biomed. Opt. Express 1(5), 1502–1513 (2010).
[CrossRef] [PubMed]

M. Belau, M. Ninck, G. Hering, L. Spinelli, D. Contini, A. Torricelli, and T. Gisler, “Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy,” J. Biomed. Opt. 15(5), 057007 (2010).
[CrossRef] [PubMed]

J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, “Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy,” Opt. Lett. 33(19), 2233–2235 (2008).
[CrossRef] [PubMed]

F. Jaillon, J. Li, G. Dietsche, T. Elbert, and T. Gisler, “Activity of the human visual cortex measured non-invasively by diffusing-wave spectroscopy,” Opt. Express 15(11), 6643–6650 (2007).
[CrossRef] [PubMed]

G. Dietsche, M. Ninck, C. Ortolf, J. Li, F. Jaillon, and T. Gisler, “Fiber-based multispeckle detection for time-resolved diffusing-wave spectroscopy: characterization and application to blood flow detection in deep tissue,” Appl. Opt. 46(35), 8506–8514 (2007).
[CrossRef] [PubMed]

J. Li, F. Jaillon, G. Dietsche, G. Maret, and T. Gisler, “Pulsation-resolved deep tissue dynamics measured with diffusing-wave spectroscopy,” Opt. Express 14(17), 7841–7851 (2006).
[CrossRef] [PubMed]

F. Jaillon, S. E. Skipetrov, J. Li, G. Dietsche, G. Maret, and T. Gisler, “Diffusing-wave spectroscopy from head-like tissue phantoms: influence of a non-scattering layer,” Opt. Express 14(22), 10181–10194 (2006).
[CrossRef] [PubMed]

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt. 10(4), 044002 (2005).
[CrossRef] [PubMed]

T. Gisler, H. Rüger, S. U. Egelhaaf, J. Tschumi, P. Schurtenberger, and J. Rička, “Mode-selective dynamic light scattering: theory versus experimental realization,” Appl. Opt. 34(18), 3546–3553 (1995).
[CrossRef] [PubMed]

Goldstone, J. C.

F. Gora, S. Shinde, C. E. Elwell, J. C. Goldstone, M. Cope, D. T. Delpy, and M. Smith, “Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: a pilot study,” J. Neurosurg. Anesthesiol. 14(3), 218–222 (2002).
[CrossRef] [PubMed]

Gora, F.

F. Gora, S. Shinde, C. E. Elwell, J. C. Goldstone, M. Cope, D. T. Delpy, and M. Smith, “Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: a pilot study,” J. Neurosurg. Anesthesiol. 14(3), 218–222 (2002).
[CrossRef] [PubMed]

Goyal, M.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Grady, M. S.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Grant, P. E.

N. Roche-Labarbe, S. A. Carp, A. Surova, M. Patel, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates’ brains in the first six weeks of life,” Hum. Brain Mapp. 31(3), 341–352 (2010).
[CrossRef] [PubMed]

Greenberg, J.

Greenberg, J. H.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef] [PubMed]

C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, “Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry,” J. Cereb. Blood Flow Metab. 24(5), 518–525 (2004).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

Grosenick, D.

A. Liebert, H. Wabnitz, D. Grosenick, and R. Macdonald, “Fiber dispersion in time domain measurements compromising the accuracy of determination of optical properties of strongly scattering media,” J. Biomed. Opt. 8(3), 512–516 (2003).
[CrossRef] [PubMed]

Grubb, R. L.

R. L. Grubb, M. E. Raichle, J. O. Eichling, and M. M. Ter-Pogossian, “The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time,” Stroke 5(5), 630–639 (1974).
[CrossRef] [PubMed]

Gulka, I. B.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Gupta, A. K.

A. Helmy, M. Vizcaychipi, and A. K. Gupta, “Traumatic brain injury: intensive care management,” Br. J. Anaesth. 99(1), 32–42 (2007).
[CrossRef] [PubMed]

Hachinski, V.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Helmy, A.

A. Helmy, M. Vizcaychipi, and A. K. Gupta, “Traumatic brain injury: intensive care management,” Br. J. Anaesth. 99(1), 32–42 (2007).
[CrossRef] [PubMed]

Henderson, B. W.

Hering, G.

M. Belau, M. Ninck, G. Hering, L. Spinelli, D. Contini, A. Torricelli, and T. Gisler, “Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy,” J. Biomed. Opt. 15(5), 057007 (2010).
[CrossRef] [PubMed]

Hogan, M. J.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Hoge, R. D.

L. Gagnon, C. Gauthier, R. D. Hoge, F. Lesage, J. Selb, and D. A. Boas, “Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system,” J. Biomed. Opt. 13(5), 054019 (2008).
[CrossRef] [PubMed]

Hsiang, D.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Hurt, H. H.

Ichord, R. N.

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

Iftime, D.

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt. 10(4), 044002 (2005).
[CrossRef] [PubMed]

Jaillon, F.

Jehanne-Lacasse, J.

Kasner, S. E.

Keymel, K. R.

Kienle, A.

Kim, M. N.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

R. C. Mesquita, N. Skuli, M. N. Kim, J. Liang, S. Schenkel, A. J. Majmundar, M. C. Simon, and A. G. Yodh, “Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia,” Biomed. Opt. Express 1(4), 1173–1187 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef] [PubMed]

Kim, Y. R.

Kimberg, D. Y.

C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
[CrossRef] [PubMed]

Kirkham, F. J.

I. G. Roberts, P. Fallon, F. J. Kirkham, P. M. Kirshbom, C. E. Cooper, M. J. Elliott, and A. D. Edwards, “Measurement of cerebral blood flow during cardiopulmonary bypass with near-infrared spectroscopy,” J. Thorac. Cardiovasc. Surg. 115(1), 94–102 (1998).
[CrossRef] [PubMed]

Kirshbom, P. M.

I. G. Roberts, P. Fallon, F. J. Kirkham, P. M. Kirshbom, C. E. Cooper, M. J. Elliott, and A. D. Edwards, “Measurement of cerebral blood flow during cardiopulmonary bypass with near-infrared spectroscopy,” J. Thorac. Cardiovasc. Surg. 115(1), 94–102 (1998).
[CrossRef] [PubMed]

Kissler, J.

Koban, L.

Kofke, W. A.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Lech, G.

G. Yu, T. Durduran, G. Lech, C. Zhou, B. Chance, E. R. Mohler, and A. G. Yodh, “Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 10(2), 024027 (2005).
[CrossRef] [PubMed]

Lee, D. H.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Lee, T.-Y.

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow,” Proc. SPIE 7555, 75550Z (2010).
[CrossRef]

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets,” J. Biomed. Opt. 15(5), 057004 (2010).
[CrossRef] [PubMed]

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt. 15(3), 037014 (2010).
[CrossRef] [PubMed]

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum. 80(5), 054302 (2009).
[CrossRef] [PubMed]

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

T.-Y. Lee, “Functional CT: physiological models,” Trends Biotechnol. 20(8), S3–S10 (2002).
[CrossRef] [PubMed]

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res. 51(5), 564–570 (2002).
[CrossRef] [PubMed]

A. Cenic, D. G. Nabavi, R. A. Craen, A. W. Gelb, and T.-Y. Lee, “Dynamic CT measurement of cerebral blood flow: a validation study,” AJNR Am. J. Neuroradiol. 20(1), 63–73 (1999).
[PubMed]

Lesage, F.

L. Gagnon, C. Gauthier, R. D. Hoge, F. Lesage, J. Selb, and D. A. Boas, “Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system,” J. Biomed. Opt. 13(5), 054019 (2008).
[CrossRef] [PubMed]

L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
[CrossRef] [PubMed]

Levine, J. M.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Li, J.

Liang, J.

Licht, D. J.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

Liebert, A.

Luckl, J.

C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
[CrossRef] [PubMed]

Macdonald, R.

Majmundar, A. J.

Maloney-Wilensky, E.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Maret, G.

Margulies, S. S.

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

Martí-Fàbregas, J.

Mason, S. E.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

Mehta, R.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Mesquita, R. C.

Migueis, M.

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets,” J. Biomed. Opt. 15(5), 057004 (2010).
[CrossRef] [PubMed]

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow,” Proc. SPIE 7555, 75550Z (2010).
[CrossRef]

Mohler, E. R.

G. Yu, T. Durduran, G. Lech, C. Zhou, B. Chance, E. R. Mohler, and A. G. Yodh, “Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 10(2), 024027 (2005).
[CrossRef] [PubMed]

Möller, M.

Montenegro, L. M.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

Moss, H. E.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Murphy, B. D.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Nabavi, D. G.

A. Cenic, D. G. Nabavi, R. A. Craen, A. W. Gelb, and T.-Y. Lee, “Dynamic CT measurement of cerebral blood flow: a validation study,” AJNR Am. J. Neuroradiol. 20(1), 63–73 (1999).
[PubMed]

Naeini, J. G.

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res. 51(5), 564–570 (2002).
[CrossRef] [PubMed]

Nicolson, S. C.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

Ninck, M.

Obrig, H.

Ortolf, C.

Paquette, A. D.

Patel, M.

N. Roche-Labarbe, S. A. Carp, A. Surova, M. Patel, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates’ brains in the first six weeks of life,” Hum. Brain Mapp. 31(3), 341–352 (2010).
[CrossRef] [PubMed]

Patterson, M. S.

Pelz, D.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Picot, P. A.

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res. 51(5), 564–570 (2002).
[CrossRef] [PubMed]

Putt, M. E.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

Raichle, M. E.

R. L. Grubb, M. E. Raichle, J. O. Eichling, and M. M. Ter-Pogossian, “The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time,” Stroke 5(5), 630–639 (1974).
[CrossRef] [PubMed]

Ralston, J.

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

Ricka, J.

Rinneberg, H.

Roberts, I. G.

I. G. Roberts, P. Fallon, F. J. Kirkham, P. M. Kirshbom, C. E. Cooper, M. J. Elliott, and A. D. Edwards, “Measurement of cerebral blood flow during cardiopulmonary bypass with near-infrared spectroscopy,” J. Thorac. Cardiovasc. Surg. 115(1), 94–102 (1998).
[CrossRef] [PubMed]

Roche-Labarbe, N.

N. Roche-Labarbe, S. A. Carp, A. Surova, M. Patel, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates’ brains in the first six weeks of life,” Hum. Brain Mapp. 31(3), 341–352 (2010).
[CrossRef] [PubMed]

Rockstroh, B.

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt. 10(4), 044002 (2005).
[CrossRef] [PubMed]

Rüger, H.

Sahlas, D. J.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Schenkel, S.

Schultz, S.

Schurtenberger, P.

Sehgal, C. M.

Selb, J.

L. Gagnon, C. Gauthier, R. D. Hoge, F. Lesage, J. Selb, and D. A. Boas, “Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system,” J. Biomed. Opt. 13(5), 054019 (2008).
[CrossRef] [PubMed]

Shah, N.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Shah, Q.

Shimazu, T.

C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
[CrossRef] [PubMed]

Shinde, S.

F. Gora, S. Shinde, C. E. Elwell, J. C. Goldstone, M. Cope, D. T. Delpy, and M. Smith, “Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: a pilot study,” J. Neurosurg. Anesthesiol. 14(3), 218–222 (2002).
[CrossRef] [PubMed]

Simon, M. C.

Skipetrov, S. E.

F. Jaillon, S. E. Skipetrov, J. Li, G. Dietsche, G. Maret, and T. Gisler, “Diffusing-wave spectroscopy from head-like tissue phantoms: influence of a non-scattering layer,” Opt. Express 14(22), 10181–10194 (2006).
[CrossRef] [PubMed]

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt. 10(4), 044002 (2005).
[CrossRef] [PubMed]

Skuli, N.

Smith, M.

F. Gora, S. Shinde, C. E. Elwell, J. C. Goldstone, M. Cope, D. T. Delpy, and M. Smith, “Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: a pilot study,” J. Neurosurg. Anesthesiol. 14(3), 218–222 (2002).
[CrossRef] [PubMed]

Spinelli, L.

M. Belau, M. Ninck, G. Hering, L. Spinelli, D. Contini, A. Torricelli, and T. Gisler, “Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy,” J. Biomed. Opt. 15(5), 057007 (2010).
[CrossRef] [PubMed]

Spray, T. L.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

Springett, R.

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res. 51(5), 564–570 (2002).
[CrossRef] [PubMed]

St Lawrence, K.

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow,” Proc. SPIE 7555, 75550Z (2010).
[CrossRef]

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets,” J. Biomed. Opt. 15(5), 057004 (2010).
[CrossRef] [PubMed]

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt. 15(3), 037014 (2010).
[CrossRef] [PubMed]

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum. 80(5), 054302 (2009).
[CrossRef] [PubMed]

Steinbrink, J.

Sunar, U.

Surova, A.

N. Roche-Labarbe, S. A. Carp, A. Surova, M. Patel, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates’ brains in the first six weeks of life,” Hum. Brain Mapp. 31(3), 341–352 (2010).
[CrossRef] [PubMed]

Symons, S.

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Takahashi, K.

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

Tchou, J. C.

Ter-Pogossian, M. M.

R. L. Grubb, M. E. Raichle, J. O. Eichling, and M. M. Ter-Pogossian, “The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time,” Stroke 5(5), 630–639 (1974).
[CrossRef] [PubMed]

Tichauer, K. M.

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt. 15(3), 037014 (2010).
[CrossRef] [PubMed]

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets,” J. Biomed. Opt. 15(5), 057004 (2010).
[CrossRef] [PubMed]

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow,” Proc. SPIE 7555, 75550Z (2010).
[CrossRef]

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum. 80(5), 054302 (2009).
[CrossRef] [PubMed]

Torricelli, A.

M. Belau, M. Ninck, G. Hering, L. Spinelli, D. Contini, A. Torricelli, and T. Gisler, “Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy,” J. Biomed. Opt. 15(5), 057007 (2010).
[CrossRef] [PubMed]

Tromberg, B. J.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Tschumi, J.

Untenberger, M.

Villringer, A.

Vizcaychipi, M.

A. Helmy, M. Vizcaychipi, and A. K. Gupta, “Traumatic brain injury: intensive care management,” Br. J. Anaesth. 99(1), 32–42 (2007).
[CrossRef] [PubMed]

Wabnitz, H.

Wang, J.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

Wolf, R. L.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Yodh, A.

Yodh, A. G.

R. C. Mesquita, N. Skuli, M. N. Kim, J. Liang, S. Schenkel, A. J. Majmundar, M. C. Simon, and A. G. Yodh, “Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia,” Biomed. Opt. Express 1(4), 1173–1187 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[CrossRef]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
[CrossRef] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30(21), 2915–2917 (2005).
[CrossRef] [PubMed]

G. Yu, T. Durduran, G. Lech, C. Zhou, B. Chance, E. R. Mohler, and A. G. Yodh, “Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 10(2), 024027 (2005).
[CrossRef] [PubMed]

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, “Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry,” J. Cereb. Blood Flow Metab. 24(5), 518–525 (2004).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

D. A. Boas and A. G. Yodh, “Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation,” J. Opt. Soc. Am. A 14(1), 192–215 (1997).
[CrossRef]

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef] [PubMed]

Yu, G.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
[CrossRef] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[CrossRef] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

C. Zhou, G. Yu, D. Furuya, J. Greenberg, A. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14(3), 1125–1144 (2006).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30(21), 2915–2917 (2005).
[CrossRef] [PubMed]

G. Yu, T. Durduran, G. Lech, C. Zhou, B. Chance, E. R. Mohler, and A. G. Yodh, “Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 10(2), 024027 (2005).
[CrossRef] [PubMed]

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, “Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry,” J. Cereb. Blood Flow Metab. 24(5), 518–525 (2004).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

Zhou, C.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
[CrossRef] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[CrossRef] [PubMed]

C. Zhou, G. Yu, D. Furuya, J. Greenberg, A. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14(3), 1125–1144 (2006).
[CrossRef] [PubMed]

G. Yu, T. Durduran, G. Lech, C. Zhou, B. Chance, E. R. Mohler, and A. G. Yodh, “Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 10(2), 024027 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30(21), 2915–2917 (2005).
[CrossRef] [PubMed]

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, “Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry,” J. Cereb. Blood Flow Metab. 24(5), 518–525 (2004).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

Zimmerman, R. A.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

Zirak, P.

AJNR Am. J. Neuroradiol.

A. Cenic, D. G. Nabavi, R. A. Craen, A. W. Gelb, and T.-Y. Lee, “Dynamic CT measurement of cerebral blood flow: a validation study,” AJNR Am. J. Neuroradiol. 20(1), 63–73 (1999).
[PubMed]

Appl. Opt.

Biomed. Opt. Express

Br. J. Anaesth.

A. Helmy, M. Vizcaychipi, and A. K. Gupta, “Traumatic brain injury: intensive care management,” Br. J. Anaesth. 99(1), 32–42 (2007).
[CrossRef] [PubMed]

Hum. Brain Mapp.

N. Roche-Labarbe, S. A. Carp, A. Surova, M. Patel, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates’ brains in the first six weeks of life,” Hum. Brain Mapp. 31(3), 341–352 (2010).
[CrossRef] [PubMed]

J. Biomed. Opt.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

A. Liebert, H. Wabnitz, D. Grosenick, and R. Macdonald, “Fiber dispersion in time domain measurements compromising the accuracy of determination of optical properties of strongly scattering media,” J. Biomed. Opt. 8(3), 512–516 (2003).
[CrossRef] [PubMed]

J. T. Elliott, M. Diop, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy,” J. Biomed. Opt. 15(3), 037014 (2010).
[CrossRef] [PubMed]

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets,” J. Biomed. Opt. 15(5), 057004 (2010).
[CrossRef] [PubMed]

L. Gagnon, C. Gauthier, R. D. Hoge, F. Lesage, J. Selb, and D. A. Boas, “Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system,” J. Biomed. Opt. 13(5), 054019 (2008).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[CrossRef] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

G. Yu, T. Durduran, G. Lech, C. Zhou, B. Chance, E. R. Mohler, and A. G. Yodh, “Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 10(2), 024027 (2005).
[CrossRef] [PubMed]

M. Belau, M. Ninck, G. Hering, L. Spinelli, D. Contini, A. Torricelli, and T. Gisler, “Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy,” J. Biomed. Opt. 15(5), 057007 (2010).
[CrossRef] [PubMed]

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt. 10(4), 044002 (2005).
[CrossRef] [PubMed]

J. Cereb. Blood Flow Metab.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

T. Durduran, M. G. Burnett, G. Yu, C. Zhou, D. Furuya, A. G. Yodh, J. A. Detre, and J. H. Greenberg, “Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser-speckle flowmetry,” J. Cereb. Blood Flow Metab. 24(5), 518–525 (2004).
[CrossRef] [PubMed]

C. Zhou, T. Shimazu, T. Durduran, J. Luckl, D. Y. Kimberg, G. Yu, X. H. Chen, J. A. Detre, A. G. Yodh, and J. H. Greenberg, “Acute functional recovery of cerebral blood flow after forebrain ischemia in rat,” J. Cereb. Blood Flow Metab. 28(7), 1275–1284 (2008).
[CrossRef] [PubMed]

J. Neurosurg. Anesthesiol.

F. Gora, S. Shinde, C. E. Elwell, J. C. Goldstone, M. Cope, D. T. Delpy, and M. Smith, “Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: a pilot study,” J. Neurosurg. Anesthesiol. 14(3), 218–222 (2002).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A

J. Thorac. Cardiovasc. Surg.

I. G. Roberts, P. Fallon, F. J. Kirkham, P. M. Kirshbom, C. E. Cooper, M. J. Elliott, and A. D. Edwards, “Measurement of cerebral blood flow during cardiopulmonary bypass with near-infrared spectroscopy,” J. Thorac. Cardiovasc. Surg. 115(1), 94–102 (1998).
[CrossRef] [PubMed]

Neurocrit. Care

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Neurologist

M. A. De Georgia and A. Deogaonkar, “Multimodal monitoring in the neurological intensive care unit,” Neurologist 11(1), 45–54 (2005).
[CrossRef] [PubMed]

Opt. Express

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef] [PubMed]

L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
[CrossRef] [PubMed]

C. Zhou, G. Yu, D. Furuya, J. Greenberg, A. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14(3), 1125–1144 (2006).
[CrossRef] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[CrossRef] [PubMed]

J. Li, F. Jaillon, G. Dietsche, G. Maret, and T. Gisler, “Pulsation-resolved deep tissue dynamics measured with diffusing-wave spectroscopy,” Opt. Express 14(17), 7841–7851 (2006).
[CrossRef] [PubMed]

F. Jaillon, S. E. Skipetrov, J. Li, G. Dietsche, G. Maret, and T. Gisler, “Diffusing-wave spectroscopy from head-like tissue phantoms: influence of a non-scattering layer,” Opt. Express 14(22), 10181–10194 (2006).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

F. Jaillon, J. Li, G. Dietsche, T. Elbert, and T. Gisler, “Activity of the human visual cortex measured non-invasively by diffusing-wave spectroscopy,” Opt. Express 15(11), 6643–6650 (2007).
[CrossRef] [PubMed]

Opt. Lett.

Pediatr. Res.

D. W. Brown, P. A. Picot, J. G. Naeini, R. Springett, D. T. Delpy, and T.-Y. Lee, “Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets,” Pediatr. Res. 51(5), 564–570 (2002).
[CrossRef] [PubMed]

Phys. Med. Biol.

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

Phys. Rev. Lett.

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef] [PubMed]

Proc. SPIE

M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St Lawrence, “Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow,” Proc. SPIE 7555, 75550Z (2010).
[CrossRef]

Rep. Prog. Phys.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[CrossRef]

Rev. Sci. Instrum.

M. Diop, J. T. Elliott, K. M. Tichauer, T.-Y. Lee, and K. St Lawrence, “A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets,” Rev. Sci. Instrum. 80(5), 054302 (2009).
[CrossRef] [PubMed]

Stroke

R. L. Grubb, M. E. Raichle, J. O. Eichling, and M. M. Ter-Pogossian, “The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time,” Stroke 5(5), 630–639 (1974).
[CrossRef] [PubMed]

B. D. Murphy, A. J. Fox, D. H. Lee, D. J. Sahlas, S. E. Black, M. J. Hogan, S. B. Coutts, A. M. Demchuk, M. Goyal, R. I. Aviv, S. Symons, I. B. Gulka, V. Beletsky, D. Pelz, V. Hachinski, R. Chan, and T.-Y. Lee, “Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements,” Stroke 37(7), 1771–1777 (2006).
[CrossRef] [PubMed]

Trends Biotechnol.

T.-Y. Lee, “Functional CT: physiological models,” Trends Biotechnol. 20(8), S3–S10 (2002).
[CrossRef] [PubMed]

Other

CDC, “Traumatic brain injury in the United States: Assessing outcomes in children,” (2000) accessed July 28, 2009, http://www.cdc.gov/ncipc/tbi/tbi_report/09_Appendix_B.htm .

C. Zhou, “In-vivo optical imaging and spectroscopy of cerebral hemodynamics,” Ph.D. thesis (University of Pennsylvania, 2007).

T. Durduran, “Non-invasive measurements of tissue hemodynamics with hybrid diffuse optical methods,” Ph.D. thesis (University of Pennsylvania, 2004).

S. Prahl, “Optical Absorption of Indocyanine Green (ICG),” http://omlc.ogi.edu/spectra/icg/index.html.

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (6)

Fig. 1
Fig. 1

Experimental protocol.

Fig. 2
Fig. 2

Typical intensity autocorrelation function measured at a source-detector distance of 2 cm on a piglet head and the best-fit curve obtained using the correlation diffusion model for a homogeneous semi-infinite medium assuming Brownian dynamics.

Fig. 3
Fig. 3

(A) Typical normalized intensity autocorrelation functions and (B) the corresponding tissue ICG curves measured at hypocapnia, normocapnia and hypercapnia in one animal. Each of the curves in (A) was obtained by averaging a set of 5 normalized intensity autocorrelation curves to improve the signal-to-noise ratio.

Fig. 4
Fig. 4

Perfusion changes measured with the TR-NIR technique compared to the corresponding changes in (A) the scaled diffusion coefficient (αDB ) and (B) area under the intensity autocorrelation curves (A).

Fig. 5
Fig. 5

Correlation between CBF and corresponding values of absolute αDB : (A) αDB was obtained using the measured optical properties for each animal and (B) αDB was determined assuming µa = 0.19 cm−1 and µs' = 7.4 cm−1 across all animals. Data are presented from the seven experiments using the single photon counting module with high quantum efficiency.

Fig. 6
Fig. 6

Effects of errors in the optical properties used in the fitting of the autocorrelation curves on the recovered αDB : g2 (ρ,τ) curves were generated by (A) incrementing µa from 0.15 to 0.26 cm−1 while keeping µs' = 8 cm−1, and (B) increasing µs' from 7 to 10 cm−1 while keeping µa = 0.2 cm−1. All autocorrelation curves were fitted with the same µa and µs' values (0.2 and 8 cm−1, respectively).

Tables (2)

Tables Icon

Table 1 Optical properties and physiological parameters measured at hypocapnia, normocapnia, moderate and severe hypercapnia, and during carotid occlusion. Data are presented as mean ± SD.

Tables Icon

Table 2 αDB and CBF values obtained from the experimental data presented in Fig. 3

Equations (10)

Equations on this page are rendered with MathJax. Learn more.

Q ( t ) = C a ( t ) F R ( t ) ,
Q ( t ) = [ ( μ a ( t ) μ a ( 0 ) ) ] / [ ln ( 10 ) × ε I C G ] ,
Δ C B F = 100 × C B F c o n d C B F n o r m o C B F n o r m o ,
g 2 ( ρ , τ ) I ( ρ , t ) I ( ρ , t + τ ) I ( ρ , t ) 2 ,
g 2 ( ρ , τ ) = 1 + β | G 1 ( ρ , τ ) | 2 I ( ρ , t ) 2 .
G 1 ( ρ , τ ) = 3 μ s ' 4 π ( exp ( k D r 1 ) r 1 exp ( k D r 2 ) r 2 ) .
Δ ( α D B ) = 100 × α D B c o n d α D B n o r m o α D B n o r m o .
A = t 1 t 2 ( g 2 ( τ ) 1 ) d τ ,
Δ A = 100 × A n o r m o A c o n d A n o r m o .
α D B e r r o r ( % ) = 100 × α D B f i t α D B r e a l α D B r e a l .

Metrics