Abstract

The establishment of multiplex photoacoustic molecular imaging to characterize heterogeneous tissues requires the use of a tunable, thermally stable contrast agent targeted to specific cell types. We have developed a multiplex photoacoustic imaging technique which uses targeted silica-coated gold nanorods to distinguish cell inclusions in vitro. This paper describes the use of tunable targeted silica-coated gold nanorods (SiO2-AuNRs) as contrast agents for photoacoustic molecular imaging. SiO2-AuNRs with peak absorption wavelengths of 780 nm and 830 nm were targeted to cells expressing different cell receptors. Cells were incubated with the targeted SiO2-AuNRs, incorporated in a tissue phantom, and imaged using multiwavelength photoacoustic imaging. We used photoacoustic imaging and statistical correlation analysis to distinguish between the unique cell inclusions within the tissue phantom.

© 2011 OSA

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2011 (2)

Y. S. Chen, W. Frey, S. Kim, P. Kruizinga, K. Homan, and S. Emelianov, “Silica-coated gold nanorods as photoacoustic signal nanoamplifiers,” Nano Lett. 11(2), 348–354 (2011).
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L. M. Ricles, S. Y. Nam, K. Sokolov, S. Y. Emelianov, and L. J. Suggs, “Function of mesenchymal stem cells following loading of gold nanotracers,” Int. J. Nanomedicine 6, 407–416 (2011).
[CrossRef] [PubMed]

2010 (4)

L.-C. Chen, C.-W. Wei, J. S. Souris, S.-H. Cheng, C.-T. Chen, C.-S. Yang, P.-C. Li, and L.-W. Lo, “Enhanced photoacoustic stability of gold nanorods by silica matrix confinement,” J. Biomed. Opt. 15(1), 016010–016016 (2010).
[CrossRef] [PubMed]

Y. S. Chen, P. Kruizinga, P. P. Joshi, S. Kim, K. Homan, K. Sokolov, W. Frey, and S. Emelianov, “On stability of molecular therapeutic agents for noninvasive photoacoustic and ultrasound image-guided photothermal therapy,” Proc. SPIE 7564, 75641Q, 75641Q-8 (2010).
[CrossRef]

F. Hallouard, N. Anton, P. Choquet, A. Constantinesco, and T. Vandamme, “Iodinated blood pool contrast media for preclinical X-ray imaging applications--a review,” Biomaterials 31(24), 6249–6268 (2010).
[CrossRef] [PubMed]

Y.-S. Chen, W. Frey, S. Kim, K. Homan, P. Kruizinga, K. Sokolov, and S. Emelianov, “Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy,” Opt. Express 18(9), 8867–8878 (2010).
[CrossRef] [PubMed]

2009 (4)

R. Goel, N. Shah, R. Visaria, G. F. Paciotti, and J. C. Bischof, “Biodistribution of TNF-alpha-coated gold nanoparticles in an in vivo model system,” Nanomedicine (Lond) 4(4), 401–410 (2009).
[CrossRef] [PubMed]

J. H. Lee, E. L. Rosen, and D. A. Mankoff, “The role of radiotracer imaging in the diagnosis and management of patients with breast cancer: part 1--overview, detection, and staging,” J. Nucl. Med. 50(4), 569–581 (2009).
[CrossRef] [PubMed]

R. Alford, M. Ogawa, P. L. Choyke, and H. Kobayashi, “Molecular probes for the in vivo imaging of cancer,” Mol. Biosyst. 5(11), 1279–1291 (2009).
[CrossRef] [PubMed]

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

2008 (3)

2007 (2)

M. Eghtedari, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, “High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system,” Nano Lett. 7(7), 1914–1918 (2007).
[CrossRef] [PubMed]

S. Mallidi, T. Larson, J. Aaron, K. Sokolov, and S. Emelianov, “Molecular specific optoacoustic imaging with plasmonic nanoparticles,” Opt. Express 15(11), 6583–6588 (2007).
[CrossRef] [PubMed]

2006 (1)

P. C. Li, C. W. Wei, C. K. Liao, C. D. Chen, K. C. Pao, C. R. C. Wang, Y. N. Wu, and D. B. Shieh, “Multiple targeting in photoacoustic imaging using bioconjugated gold nanorods,” Proc. SPIE 6086, 60860M, 60860M-10 (2006).
[CrossRef]

2004 (3)

D. M. Abd El-Rehim, S. E. Pinder, C. E. Paish, J. A. Bell, R. S. Rampaul, R. W. Blamey, J. F. R. Robertson, R. I. Nicholson, and I. O. Ellis, “Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma,” Br. J. Cancer 91(8), 1532–1542 (2004).
[CrossRef] [PubMed]

J. A. Copland, M. Eghtedari, V. L. Popov, N. Kotov, N. Mamedova, M. Motamedi, and A. A. Oraevsky, “Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography,” Mol. Imaging Biol. 6(5), 341–349 (2004).
[CrossRef] [PubMed]

X. D. Wang, G. Ku, X. Y. Xie, M. A. Wegiel, D. J. Bornhop, G. Stoica, and L. V. Wang, ““Laser-induced photoacoustic tomography enhanced with an optical contrast agent,” Proc. SPIE 5320, 77–82 (2004).
[CrossRef]

2003 (3)

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[CrossRef] [PubMed]

S. Tsutsui, S. Ohno, S. Murakami, A. Kataoka, J. Kinoshita, and Y. Hachitanda, “Prognostic value of the combination of epidermal growth factor receptor and c-erbB-2 in breast cancer,” Surgery 133(2), 219–221 (2003).
[CrossRef] [PubMed]

S. Dagar, A. Krishnadas, I. Rubinstein, M. J. Blend, and H. Onyüksel, “VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies,” J. Control. Release 91(1-2), 123–133 (2003).
[CrossRef] [PubMed]

2002 (2)

J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
[PubMed]

V. Ntziachristos, J. Ripoll, and R. Weissleder, “Would near-infrared fluorescence signals propagate through large human organs for clinical studies?” Opt. Lett. 27(5), 333–335 (2002).
[CrossRef] [PubMed]

2001 (5)

R. Bei, G. Pompa, D. Vitolo, E. Moriconi, L. Ciocci, M. Quaranta, L. Frati, M. H. Kraus, and R. Muraro, “Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma,” J. Pathol. 195(3), 343–348 (2001).
[CrossRef] [PubMed]

R. I. Nicholson, J. M. W. Gee, and M. E. Harper, “EGFR and cancer prognosis,” Eur. J. Cancer 37(Suppl 4), 9–15 (2001).
[CrossRef] [PubMed]

A. A. Oraevsky, A. A. Karabutov, and E. V. Savateeva, “Enhancement of optoacoustic tissue contrast with absorbing nanoparticles,” Proc. SPIE 4434, 60–69 (2001).
[CrossRef]

M. M. Moasser, A. Basso, S. D. Averbuch, and N. Rosen, “The tyrosine kinase inhibitor ZD1839 (“Iressa”) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells,” Cancer Res. 61(19), 7184–7188 (2001).
[PubMed]

N. R. Jana, L. Gearheart, and C. J. Murphy, “Seed-mediated growth approach for shape-controlled synthesis of spheroidal and rod-like gold nanoparticles using a surfactant template,” Adv. Mater. (Deerfield Beach Fla.) 13(18), 1389–1393 (2001).
[CrossRef]

1994 (1)

R. A. Kruger, “Photoacoustic ultrasound,” Med. Phys. 21(1), 127–131 (1994).
[CrossRef] [PubMed]

1993 (1)

H. Masui, L. Castro, and J. Mendelsohn, “Consumption of EGF by A431 cells: evidence for receptor recycling,” J. Cell Biol. 120(1), 85–93 (1993).
[CrossRef] [PubMed]

1988 (1)

H. S. Wiley, “Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system,” J. Cell Biol. 107(2), 801–810 (1988).
[CrossRef] [PubMed]

1986 (1)

W. Roos, D. Fabbro, W. Küng, S. D. Costa, and U. Eppenberger, “Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cells,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 991–995 (1986).
[CrossRef] [PubMed]

Aaron, J.

S. Kumar, J. Aaron, and K. Sokolov, “Directional conjugation of antibodies to nanoparticles for synthesis of multiplexed optical contrast agents with both delivery and targeting moieties,” Nat. Protoc. 3(2), 314–320 (2008).
[CrossRef] [PubMed]

S. Mallidi, T. Larson, J. Aaron, K. Sokolov, and S. Emelianov, “Molecular specific optoacoustic imaging with plasmonic nanoparticles,” Opt. Express 15(11), 6583–6588 (2007).
[CrossRef] [PubMed]

Abd El-Rehim, D. M.

D. M. Abd El-Rehim, S. E. Pinder, C. E. Paish, J. A. Bell, R. S. Rampaul, R. W. Blamey, J. F. R. Robertson, R. I. Nicholson, and I. O. Ellis, “Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma,” Br. J. Cancer 91(8), 1532–1542 (2004).
[CrossRef] [PubMed]

Alford, R.

R. Alford, M. Ogawa, P. L. Choyke, and H. Kobayashi, “Molecular probes for the in vivo imaging of cancer,” Mol. Biosyst. 5(11), 1279–1291 (2009).
[CrossRef] [PubMed]

Amirian, J. H.

Anton, N.

F. Hallouard, N. Anton, P. Choquet, A. Constantinesco, and T. Vandamme, “Iodinated blood pool contrast media for preclinical X-ray imaging applications--a review,” Biomaterials 31(24), 6249–6268 (2010).
[CrossRef] [PubMed]

Averbuch, S. D.

M. M. Moasser, A. Basso, S. D. Averbuch, and N. Rosen, “The tyrosine kinase inhibitor ZD1839 (“Iressa”) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells,” Cancer Res. 61(19), 7184–7188 (2001).
[PubMed]

Baselga, J.

J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
[PubMed]

Basso, A.

M. M. Moasser, A. Basso, S. D. Averbuch, and N. Rosen, “The tyrosine kinase inhibitor ZD1839 (“Iressa”) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells,” Cancer Res. 61(19), 7184–7188 (2001).
[PubMed]

Bei, R.

R. Bei, G. Pompa, D. Vitolo, E. Moriconi, L. Ciocci, M. Quaranta, L. Frati, M. H. Kraus, and R. Muraro, “Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma,” J. Pathol. 195(3), 343–348 (2001).
[CrossRef] [PubMed]

Bell, J. A.

D. M. Abd El-Rehim, S. E. Pinder, C. E. Paish, J. A. Bell, R. S. Rampaul, R. W. Blamey, J. F. R. Robertson, R. I. Nicholson, and I. O. Ellis, “Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma,” Br. J. Cancer 91(8), 1532–1542 (2004).
[CrossRef] [PubMed]

Benz, C. C.

J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
[PubMed]

Bischof, J. C.

R. Goel, N. Shah, R. Visaria, G. F. Paciotti, and J. C. Bischof, “Biodistribution of TNF-alpha-coated gold nanoparticles in an in vivo model system,” Nanomedicine (Lond) 4(4), 401–410 (2009).
[CrossRef] [PubMed]

Blamey, R. W.

D. M. Abd El-Rehim, S. E. Pinder, C. E. Paish, J. A. Bell, R. S. Rampaul, R. W. Blamey, J. F. R. Robertson, R. I. Nicholson, and I. O. Ellis, “Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma,” Br. J. Cancer 91(8), 1532–1542 (2004).
[CrossRef] [PubMed]

Blend, M. J.

S. Dagar, A. Krishnadas, I. Rubinstein, M. J. Blend, and H. Onyüksel, “VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies,” J. Control. Release 91(1-2), 123–133 (2003).
[CrossRef] [PubMed]

Bornhop, D. J.

X. D. Wang, G. Ku, X. Y. Xie, M. A. Wegiel, D. J. Bornhop, G. Stoica, and L. V. Wang, ““Laser-induced photoacoustic tomography enhanced with an optical contrast agent,” Proc. SPIE 5320, 77–82 (2004).
[CrossRef]

Castro, L.

H. Masui, L. Castro, and J. Mendelsohn, “Consumption of EGF by A431 cells: evidence for receptor recycling,” J. Cell Biol. 120(1), 85–93 (1993).
[CrossRef] [PubMed]

Chen, C. D.

P. C. Li, C. W. Wei, C. K. Liao, C. D. Chen, K. C. Pao, C. R. C. Wang, Y. N. Wu, and D. B. Shieh, “Multiple targeting in photoacoustic imaging using bioconjugated gold nanorods,” Proc. SPIE 6086, 60860M, 60860M-10 (2006).
[CrossRef]

Chen, C.-T.

L.-C. Chen, C.-W. Wei, J. S. Souris, S.-H. Cheng, C.-T. Chen, C.-S. Yang, P.-C. Li, and L.-W. Lo, “Enhanced photoacoustic stability of gold nanorods by silica matrix confinement,” J. Biomed. Opt. 15(1), 016010–016016 (2010).
[CrossRef] [PubMed]

Chen, L.-C.

L.-C. Chen, C.-W. Wei, J. S. Souris, S.-H. Cheng, C.-T. Chen, C.-S. Yang, P.-C. Li, and L.-W. Lo, “Enhanced photoacoustic stability of gold nanorods by silica matrix confinement,” J. Biomed. Opt. 15(1), 016010–016016 (2010).
[CrossRef] [PubMed]

Chen, Y. S.

Y. S. Chen, W. Frey, S. Kim, P. Kruizinga, K. Homan, and S. Emelianov, “Silica-coated gold nanorods as photoacoustic signal nanoamplifiers,” Nano Lett. 11(2), 348–354 (2011).
[CrossRef] [PubMed]

Y. S. Chen, P. Kruizinga, P. P. Joshi, S. Kim, K. Homan, K. Sokolov, W. Frey, and S. Emelianov, “On stability of molecular therapeutic agents for noninvasive photoacoustic and ultrasound image-guided photothermal therapy,” Proc. SPIE 7564, 75641Q, 75641Q-8 (2010).
[CrossRef]

Chen, Y.-S.

Cheng, S.-H.

L.-C. Chen, C.-W. Wei, J. S. Souris, S.-H. Cheng, C.-T. Chen, C.-S. Yang, P.-C. Li, and L.-W. Lo, “Enhanced photoacoustic stability of gold nanorods by silica matrix confinement,” J. Biomed. Opt. 15(1), 016010–016016 (2010).
[CrossRef] [PubMed]

Choquet, P.

F. Hallouard, N. Anton, P. Choquet, A. Constantinesco, and T. Vandamme, “Iodinated blood pool contrast media for preclinical X-ray imaging applications--a review,” Biomaterials 31(24), 6249–6268 (2010).
[CrossRef] [PubMed]

Choyke, P. L.

R. Alford, M. Ogawa, P. L. Choyke, and H. Kobayashi, “Molecular probes for the in vivo imaging of cancer,” Mol. Biosyst. 5(11), 1279–1291 (2009).
[CrossRef] [PubMed]

Ciocci, L.

R. Bei, G. Pompa, D. Vitolo, E. Moriconi, L. Ciocci, M. Quaranta, L. Frati, M. H. Kraus, and R. Muraro, “Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma,” J. Pathol. 195(3), 343–348 (2001).
[CrossRef] [PubMed]

Colbern, G.

J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
[PubMed]

Conjusteau, A.

M. Eghtedari, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, “High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system,” Nano Lett. 7(7), 1914–1918 (2007).
[CrossRef] [PubMed]

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F. Hallouard, N. Anton, P. Choquet, A. Constantinesco, and T. Vandamme, “Iodinated blood pool contrast media for preclinical X-ray imaging applications--a review,” Biomaterials 31(24), 6249–6268 (2010).
[CrossRef] [PubMed]

Copland, J. A.

M. Eghtedari, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, “High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system,” Nano Lett. 7(7), 1914–1918 (2007).
[CrossRef] [PubMed]

J. A. Copland, M. Eghtedari, V. L. Popov, N. Kotov, N. Mamedova, M. Motamedi, and A. A. Oraevsky, “Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography,” Mol. Imaging Biol. 6(5), 341–349 (2004).
[CrossRef] [PubMed]

Costa, S. D.

W. Roos, D. Fabbro, W. Küng, S. D. Costa, and U. Eppenberger, “Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cells,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 991–995 (1986).
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S. Dagar, A. Krishnadas, I. Rubinstein, M. J. Blend, and H. Onyüksel, “VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies,” J. Control. Release 91(1-2), 123–133 (2003).
[CrossRef] [PubMed]

Ding, A.-A.

Eghtedari, M.

M. Eghtedari, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, “High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system,” Nano Lett. 7(7), 1914–1918 (2007).
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J. A. Copland, M. Eghtedari, V. L. Popov, N. Kotov, N. Mamedova, M. Motamedi, and A. A. Oraevsky, “Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography,” Mol. Imaging Biol. 6(5), 341–349 (2004).
[CrossRef] [PubMed]

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D. M. Abd El-Rehim, S. E. Pinder, C. E. Paish, J. A. Bell, R. S. Rampaul, R. W. Blamey, J. F. R. Robertson, R. I. Nicholson, and I. O. Ellis, “Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma,” Br. J. Cancer 91(8), 1532–1542 (2004).
[CrossRef] [PubMed]

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Y. S. Chen, W. Frey, S. Kim, P. Kruizinga, K. Homan, and S. Emelianov, “Silica-coated gold nanorods as photoacoustic signal nanoamplifiers,” Nano Lett. 11(2), 348–354 (2011).
[CrossRef] [PubMed]

Y.-S. Chen, W. Frey, S. Kim, K. Homan, P. Kruizinga, K. Sokolov, and S. Emelianov, “Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy,” Opt. Express 18(9), 8867–8878 (2010).
[CrossRef] [PubMed]

Y. S. Chen, P. Kruizinga, P. P. Joshi, S. Kim, K. Homan, K. Sokolov, W. Frey, and S. Emelianov, “On stability of molecular therapeutic agents for noninvasive photoacoustic and ultrasound image-guided photothermal therapy,” Proc. SPIE 7564, 75641Q, 75641Q-8 (2010).
[CrossRef]

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

S. Mallidi, T. Larson, J. Aaron, K. Sokolov, and S. Emelianov, “Molecular specific optoacoustic imaging with plasmonic nanoparticles,” Opt. Express 15(11), 6583–6588 (2007).
[CrossRef] [PubMed]

Emelianov, S. Y.

L. M. Ricles, S. Y. Nam, K. Sokolov, S. Y. Emelianov, and L. J. Suggs, “Function of mesenchymal stem cells following loading of gold nanotracers,” Int. J. Nanomedicine 6, 407–416 (2011).
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S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express 16(5), 3362–3367 (2008).
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Eppenberger, U.

W. Roos, D. Fabbro, W. Küng, S. D. Costa, and U. Eppenberger, “Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cells,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 991–995 (1986).
[CrossRef] [PubMed]

Fabbro, D.

W. Roos, D. Fabbro, W. Küng, S. D. Costa, and U. Eppenberger, “Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cells,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 991–995 (1986).
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Frati, L.

R. Bei, G. Pompa, D. Vitolo, E. Moriconi, L. Ciocci, M. Quaranta, L. Frati, M. H. Kraus, and R. Muraro, “Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma,” J. Pathol. 195(3), 343–348 (2001).
[CrossRef] [PubMed]

Frey, W.

Y. S. Chen, W. Frey, S. Kim, P. Kruizinga, K. Homan, and S. Emelianov, “Silica-coated gold nanorods as photoacoustic signal nanoamplifiers,” Nano Lett. 11(2), 348–354 (2011).
[CrossRef] [PubMed]

Y.-S. Chen, W. Frey, S. Kim, K. Homan, P. Kruizinga, K. Sokolov, and S. Emelianov, “Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy,” Opt. Express 18(9), 8867–8878 (2010).
[CrossRef] [PubMed]

Y. S. Chen, P. Kruizinga, P. P. Joshi, S. Kim, K. Homan, K. Sokolov, W. Frey, and S. Emelianov, “On stability of molecular therapeutic agents for noninvasive photoacoustic and ultrasound image-guided photothermal therapy,” Proc. SPIE 7564, 75641Q, 75641Q-8 (2010).
[CrossRef]

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N. R. Jana, L. Gearheart, and C. J. Murphy, “Seed-mediated growth approach for shape-controlled synthesis of spheroidal and rod-like gold nanoparticles using a surfactant template,” Adv. Mater. (Deerfield Beach Fla.) 13(18), 1389–1393 (2001).
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R. I. Nicholson, J. M. W. Gee, and M. E. Harper, “EGFR and cancer prognosis,” Eur. J. Cancer 37(Suppl 4), 9–15 (2001).
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R. Goel, N. Shah, R. Visaria, G. F. Paciotti, and J. C. Bischof, “Biodistribution of TNF-alpha-coated gold nanoparticles in an in vivo model system,” Nanomedicine (Lond) 4(4), 401–410 (2009).
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S. Tsutsui, S. Ohno, S. Murakami, A. Kataoka, J. Kinoshita, and Y. Hachitanda, “Prognostic value of the combination of epidermal growth factor receptor and c-erbB-2 in breast cancer,” Surgery 133(2), 219–221 (2003).
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F. Hallouard, N. Anton, P. Choquet, A. Constantinesco, and T. Vandamme, “Iodinated blood pool contrast media for preclinical X-ray imaging applications--a review,” Biomaterials 31(24), 6249–6268 (2010).
[CrossRef] [PubMed]

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R. I. Nicholson, J. M. W. Gee, and M. E. Harper, “EGFR and cancer prognosis,” Eur. J. Cancer 37(Suppl 4), 9–15 (2001).
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Y. S. Chen, W. Frey, S. Kim, P. Kruizinga, K. Homan, and S. Emelianov, “Silica-coated gold nanorods as photoacoustic signal nanoamplifiers,” Nano Lett. 11(2), 348–354 (2011).
[CrossRef] [PubMed]

Y.-S. Chen, W. Frey, S. Kim, K. Homan, P. Kruizinga, K. Sokolov, and S. Emelianov, “Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy,” Opt. Express 18(9), 8867–8878 (2010).
[CrossRef] [PubMed]

Y. S. Chen, P. Kruizinga, P. P. Joshi, S. Kim, K. Homan, K. Sokolov, W. Frey, and S. Emelianov, “On stability of molecular therapeutic agents for noninvasive photoacoustic and ultrasound image-guided photothermal therapy,” Proc. SPIE 7564, 75641Q, 75641Q-8 (2010).
[CrossRef]

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J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
[PubMed]

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N. R. Jana, L. Gearheart, and C. J. Murphy, “Seed-mediated growth approach for shape-controlled synthesis of spheroidal and rod-like gold nanoparticles using a surfactant template,” Adv. Mater. (Deerfield Beach Fla.) 13(18), 1389–1393 (2001).
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Jhan, S.

Joshi, P. P.

Y. S. Chen, P. Kruizinga, P. P. Joshi, S. Kim, K. Homan, K. Sokolov, W. Frey, and S. Emelianov, “On stability of molecular therapeutic agents for noninvasive photoacoustic and ultrasound image-guided photothermal therapy,” Proc. SPIE 7564, 75641Q, 75641Q-8 (2010).
[CrossRef]

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
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A. A. Oraevsky, A. A. Karabutov, and E. V. Savateeva, “Enhancement of optoacoustic tissue contrast with absorbing nanoparticles,” Proc. SPIE 4434, 60–69 (2001).
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S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

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S. Tsutsui, S. Ohno, S. Murakami, A. Kataoka, J. Kinoshita, and Y. Hachitanda, “Prognostic value of the combination of epidermal growth factor receptor and c-erbB-2 in breast cancer,” Surgery 133(2), 219–221 (2003).
[CrossRef] [PubMed]

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Y. S. Chen, W. Frey, S. Kim, P. Kruizinga, K. Homan, and S. Emelianov, “Silica-coated gold nanorods as photoacoustic signal nanoamplifiers,” Nano Lett. 11(2), 348–354 (2011).
[CrossRef] [PubMed]

Y.-S. Chen, W. Frey, S. Kim, K. Homan, P. Kruizinga, K. Sokolov, and S. Emelianov, “Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy,” Opt. Express 18(9), 8867–8878 (2010).
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Y. S. Chen, P. Kruizinga, P. P. Joshi, S. Kim, K. Homan, K. Sokolov, W. Frey, and S. Emelianov, “On stability of molecular therapeutic agents for noninvasive photoacoustic and ultrasound image-guided photothermal therapy,” Proc. SPIE 7564, 75641Q, 75641Q-8 (2010).
[CrossRef]

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S. Tsutsui, S. Ohno, S. Murakami, A. Kataoka, J. Kinoshita, and Y. Hachitanda, “Prognostic value of the combination of epidermal growth factor receptor and c-erbB-2 in breast cancer,” Surgery 133(2), 219–221 (2003).
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J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
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J. A. Copland, M. Eghtedari, V. L. Popov, N. Kotov, N. Mamedova, M. Motamedi, and A. A. Oraevsky, “Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography,” Mol. Imaging Biol. 6(5), 341–349 (2004).
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Kotov, N. A.

M. Eghtedari, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, “High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system,” Nano Lett. 7(7), 1914–1918 (2007).
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R. Bei, G. Pompa, D. Vitolo, E. Moriconi, L. Ciocci, M. Quaranta, L. Frati, M. H. Kraus, and R. Muraro, “Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma,” J. Pathol. 195(3), 343–348 (2001).
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S. Dagar, A. Krishnadas, I. Rubinstein, M. J. Blend, and H. Onyüksel, “VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies,” J. Control. Release 91(1-2), 123–133 (2003).
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Y. S. Chen, W. Frey, S. Kim, P. Kruizinga, K. Homan, and S. Emelianov, “Silica-coated gold nanorods as photoacoustic signal nanoamplifiers,” Nano Lett. 11(2), 348–354 (2011).
[CrossRef] [PubMed]

Y.-S. Chen, W. Frey, S. Kim, K. Homan, P. Kruizinga, K. Sokolov, and S. Emelianov, “Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy,” Opt. Express 18(9), 8867–8878 (2010).
[CrossRef] [PubMed]

Y. S. Chen, P. Kruizinga, P. P. Joshi, S. Kim, K. Homan, K. Sokolov, W. Frey, and S. Emelianov, “On stability of molecular therapeutic agents for noninvasive photoacoustic and ultrasound image-guided photothermal therapy,” Proc. SPIE 7564, 75641Q, 75641Q-8 (2010).
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X. D. Wang, G. Ku, X. Y. Xie, M. A. Wegiel, D. J. Bornhop, G. Stoica, and L. V. Wang, ““Laser-induced photoacoustic tomography enhanced with an optical contrast agent,” Proc. SPIE 5320, 77–82 (2004).
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X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
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S. Kumar, J. Aaron, and K. Sokolov, “Directional conjugation of antibodies to nanoparticles for synthesis of multiplexed optical contrast agents with both delivery and targeting moieties,” Nat. Protoc. 3(2), 314–320 (2008).
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W. Roos, D. Fabbro, W. Küng, S. D. Costa, and U. Eppenberger, “Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cells,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 991–995 (1986).
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Larson, T.

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

S. Mallidi, T. Larson, J. Aaron, K. Sokolov, and S. Emelianov, “Molecular specific optoacoustic imaging with plasmonic nanoparticles,” Opt. Express 15(11), 6583–6588 (2007).
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Lee, J. H.

J. H. Lee, E. L. Rosen, and D. A. Mankoff, “The role of radiotracer imaging in the diagnosis and management of patients with breast cancer: part 1--overview, detection, and staging,” J. Nucl. Med. 50(4), 569–581 (2009).
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P. C. Li, C. W. Wei, C. K. Liao, C. D. Chen, K. C. Pao, C. R. C. Wang, Y. N. Wu, and D. B. Shieh, “Multiple targeting in photoacoustic imaging using bioconjugated gold nanorods,” Proc. SPIE 6086, 60860M, 60860M-10 (2006).
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L.-C. Chen, C.-W. Wei, J. S. Souris, S.-H. Cheng, C.-T. Chen, C.-S. Yang, P.-C. Li, and L.-W. Lo, “Enhanced photoacoustic stability of gold nanorods by silica matrix confinement,” J. Biomed. Opt. 15(1), 016010–016016 (2010).
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P.-C. Li, C.-R. C. Wang, D.-B. Shieh, C.-W. Wei, C.-K. Liao, C. Poe, S. Jhan, A.-A. Ding, and Y.-N. Wu, “In vivo photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods,” Opt. Express 16(23), 18605–18615 (2008).
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P. C. Li, C. W. Wei, C. K. Liao, C. D. Chen, K. C. Pao, C. R. C. Wang, Y. N. Wu, and D. B. Shieh, “Multiple targeting in photoacoustic imaging using bioconjugated gold nanorods,” Proc. SPIE 6086, 60860M, 60860M-10 (2006).
[CrossRef]

Liao, C.-K.

Litovsky, S. H.

Lo, L.-W.

L.-C. Chen, C.-W. Wei, J. S. Souris, S.-H. Cheng, C.-T. Chen, C.-S. Yang, P.-C. Li, and L.-W. Lo, “Enhanced photoacoustic stability of gold nanorods by silica matrix confinement,” J. Biomed. Opt. 15(1), 016010–016016 (2010).
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S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

S. Mallidi, T. Larson, J. Aaron, K. Sokolov, and S. Emelianov, “Molecular specific optoacoustic imaging with plasmonic nanoparticles,” Opt. Express 15(11), 6583–6588 (2007).
[CrossRef] [PubMed]

Mamedova, N.

J. A. Copland, M. Eghtedari, V. L. Popov, N. Kotov, N. Mamedova, M. Motamedi, and A. A. Oraevsky, “Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography,” Mol. Imaging Biol. 6(5), 341–349 (2004).
[CrossRef] [PubMed]

Mankoff, D. A.

J. H. Lee, E. L. Rosen, and D. A. Mankoff, “The role of radiotracer imaging in the diagnosis and management of patients with breast cancer: part 1--overview, detection, and staging,” J. Nucl. Med. 50(4), 569–581 (2009).
[CrossRef] [PubMed]

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J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
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M. M. Moasser, A. Basso, S. D. Averbuch, and N. Rosen, “The tyrosine kinase inhibitor ZD1839 (“Iressa”) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells,” Cancer Res. 61(19), 7184–7188 (2001).
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J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
[PubMed]

Moriconi, E.

R. Bei, G. Pompa, D. Vitolo, E. Moriconi, L. Ciocci, M. Quaranta, L. Frati, M. H. Kraus, and R. Muraro, “Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma,” J. Pathol. 195(3), 343–348 (2001).
[CrossRef] [PubMed]

Motamedi, M.

M. Eghtedari, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, “High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system,” Nano Lett. 7(7), 1914–1918 (2007).
[CrossRef] [PubMed]

J. A. Copland, M. Eghtedari, V. L. Popov, N. Kotov, N. Mamedova, M. Motamedi, and A. A. Oraevsky, “Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography,” Mol. Imaging Biol. 6(5), 341–349 (2004).
[CrossRef] [PubMed]

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S. Tsutsui, S. Ohno, S. Murakami, A. Kataoka, J. Kinoshita, and Y. Hachitanda, “Prognostic value of the combination of epidermal growth factor receptor and c-erbB-2 in breast cancer,” Surgery 133(2), 219–221 (2003).
[CrossRef] [PubMed]

Muraro, R.

R. Bei, G. Pompa, D. Vitolo, E. Moriconi, L. Ciocci, M. Quaranta, L. Frati, M. H. Kraus, and R. Muraro, “Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma,” J. Pathol. 195(3), 343–348 (2001).
[CrossRef] [PubMed]

Murphy, C. J.

N. R. Jana, L. Gearheart, and C. J. Murphy, “Seed-mediated growth approach for shape-controlled synthesis of spheroidal and rod-like gold nanoparticles using a surfactant template,” Adv. Mater. (Deerfield Beach Fla.) 13(18), 1389–1393 (2001).
[CrossRef]

Nam, S. Y.

L. M. Ricles, S. Y. Nam, K. Sokolov, S. Y. Emelianov, and L. J. Suggs, “Function of mesenchymal stem cells following loading of gold nanotracers,” Int. J. Nanomedicine 6, 407–416 (2011).
[CrossRef] [PubMed]

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D. M. Abd El-Rehim, S. E. Pinder, C. E. Paish, J. A. Bell, R. S. Rampaul, R. W. Blamey, J. F. R. Robertson, R. I. Nicholson, and I. O. Ellis, “Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma,” Br. J. Cancer 91(8), 1532–1542 (2004).
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R. I. Nicholson, J. M. W. Gee, and M. E. Harper, “EGFR and cancer prognosis,” Eur. J. Cancer 37(Suppl 4), 9–15 (2001).
[CrossRef] [PubMed]

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J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
[PubMed]

Ntziachristos, V.

Ogawa, M.

R. Alford, M. Ogawa, P. L. Choyke, and H. Kobayashi, “Molecular probes for the in vivo imaging of cancer,” Mol. Biosyst. 5(11), 1279–1291 (2009).
[CrossRef] [PubMed]

Ohno, S.

S. Tsutsui, S. Ohno, S. Murakami, A. Kataoka, J. Kinoshita, and Y. Hachitanda, “Prognostic value of the combination of epidermal growth factor receptor and c-erbB-2 in breast cancer,” Surgery 133(2), 219–221 (2003).
[CrossRef] [PubMed]

Onyüksel, H.

S. Dagar, A. Krishnadas, I. Rubinstein, M. J. Blend, and H. Onyüksel, “VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies,” J. Control. Release 91(1-2), 123–133 (2003).
[CrossRef] [PubMed]

Oraevsky, A.

M. Eghtedari, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, “High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system,” Nano Lett. 7(7), 1914–1918 (2007).
[CrossRef] [PubMed]

Oraevsky, A. A.

J. A. Copland, M. Eghtedari, V. L. Popov, N. Kotov, N. Mamedova, M. Motamedi, and A. A. Oraevsky, “Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography,” Mol. Imaging Biol. 6(5), 341–349 (2004).
[CrossRef] [PubMed]

A. A. Oraevsky, A. A. Karabutov, and E. V. Savateeva, “Enhancement of optoacoustic tissue contrast with absorbing nanoparticles,” Proc. SPIE 4434, 60–69 (2001).
[CrossRef]

Paciotti, G. F.

R. Goel, N. Shah, R. Visaria, G. F. Paciotti, and J. C. Bischof, “Biodistribution of TNF-alpha-coated gold nanoparticles in an in vivo model system,” Nanomedicine (Lond) 4(4), 401–410 (2009).
[CrossRef] [PubMed]

Paish, C. E.

D. M. Abd El-Rehim, S. E. Pinder, C. E. Paish, J. A. Bell, R. S. Rampaul, R. W. Blamey, J. F. R. Robertson, R. I. Nicholson, and I. O. Ellis, “Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma,” Br. J. Cancer 91(8), 1532–1542 (2004).
[CrossRef] [PubMed]

Pang, Y.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[CrossRef] [PubMed]

Pao, K. C.

P. C. Li, C. W. Wei, C. K. Liao, C. D. Chen, K. C. Pao, C. R. C. Wang, Y. N. Wu, and D. B. Shieh, “Multiple targeting in photoacoustic imaging using bioconjugated gold nanorods,” Proc. SPIE 6086, 60860M, 60860M-10 (2006).
[CrossRef]

Papahadjopoulos, D.

J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
[PubMed]

Park, J. W.

J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
[PubMed]

Pinder, S. E.

D. M. Abd El-Rehim, S. E. Pinder, C. E. Paish, J. A. Bell, R. S. Rampaul, R. W. Blamey, J. F. R. Robertson, R. I. Nicholson, and I. O. Ellis, “Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma,” Br. J. Cancer 91(8), 1532–1542 (2004).
[CrossRef] [PubMed]

Poe, C.

Pompa, G.

R. Bei, G. Pompa, D. Vitolo, E. Moriconi, L. Ciocci, M. Quaranta, L. Frati, M. H. Kraus, and R. Muraro, “Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma,” J. Pathol. 195(3), 343–348 (2001).
[CrossRef] [PubMed]

Popov, V. L.

J. A. Copland, M. Eghtedari, V. L. Popov, N. Kotov, N. Mamedova, M. Motamedi, and A. A. Oraevsky, “Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography,” Mol. Imaging Biol. 6(5), 341–349 (2004).
[CrossRef] [PubMed]

Quaranta, M.

R. Bei, G. Pompa, D. Vitolo, E. Moriconi, L. Ciocci, M. Quaranta, L. Frati, M. H. Kraus, and R. Muraro, “Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma,” J. Pathol. 195(3), 343–348 (2001).
[CrossRef] [PubMed]

Rampaul, R. S.

D. M. Abd El-Rehim, S. E. Pinder, C. E. Paish, J. A. Bell, R. S. Rampaul, R. W. Blamey, J. F. R. Robertson, R. I. Nicholson, and I. O. Ellis, “Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma,” Br. J. Cancer 91(8), 1532–1542 (2004).
[CrossRef] [PubMed]

Ricles, L. M.

L. M. Ricles, S. Y. Nam, K. Sokolov, S. Y. Emelianov, and L. J. Suggs, “Function of mesenchymal stem cells following loading of gold nanotracers,” Int. J. Nanomedicine 6, 407–416 (2011).
[CrossRef] [PubMed]

Ripoll, J.

Robertson, J. F. R.

D. M. Abd El-Rehim, S. E. Pinder, C. E. Paish, J. A. Bell, R. S. Rampaul, R. W. Blamey, J. F. R. Robertson, R. I. Nicholson, and I. O. Ellis, “Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma,” Br. J. Cancer 91(8), 1532–1542 (2004).
[CrossRef] [PubMed]

Roos, W.

W. Roos, D. Fabbro, W. Küng, S. D. Costa, and U. Eppenberger, “Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cells,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 991–995 (1986).
[CrossRef] [PubMed]

Rosen, E. L.

J. H. Lee, E. L. Rosen, and D. A. Mankoff, “The role of radiotracer imaging in the diagnosis and management of patients with breast cancer: part 1--overview, detection, and staging,” J. Nucl. Med. 50(4), 569–581 (2009).
[CrossRef] [PubMed]

Rosen, N.

M. M. Moasser, A. Basso, S. D. Averbuch, and N. Rosen, “The tyrosine kinase inhibitor ZD1839 (“Iressa”) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells,” Cancer Res. 61(19), 7184–7188 (2001).
[PubMed]

Rubinstein, I.

S. Dagar, A. Krishnadas, I. Rubinstein, M. J. Blend, and H. Onyüksel, “VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies,” J. Control. Release 91(1-2), 123–133 (2003).
[CrossRef] [PubMed]

Savateeva, E. V.

A. A. Oraevsky, A. A. Karabutov, and E. V. Savateeva, “Enhancement of optoacoustic tissue contrast with absorbing nanoparticles,” Proc. SPIE 4434, 60–69 (2001).
[CrossRef]

Sethuraman, S.

Shah, N.

R. Goel, N. Shah, R. Visaria, G. F. Paciotti, and J. C. Bischof, “Biodistribution of TNF-alpha-coated gold nanoparticles in an in vivo model system,” Nanomedicine (Lond) 4(4), 401–410 (2009).
[CrossRef] [PubMed]

Shalaby, R.

J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
[PubMed]

Shao, Y.

J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
[PubMed]

Shieh, D. B.

P. C. Li, C. W. Wei, C. K. Liao, C. D. Chen, K. C. Pao, C. R. C. Wang, Y. N. Wu, and D. B. Shieh, “Multiple targeting in photoacoustic imaging using bioconjugated gold nanorods,” Proc. SPIE 6086, 60860M, 60860M-10 (2006).
[CrossRef]

Shieh, D.-B.

Smalling, R. W.

Sokolov, K.

L. M. Ricles, S. Y. Nam, K. Sokolov, S. Y. Emelianov, and L. J. Suggs, “Function of mesenchymal stem cells following loading of gold nanotracers,” Int. J. Nanomedicine 6, 407–416 (2011).
[CrossRef] [PubMed]

Y. S. Chen, P. Kruizinga, P. P. Joshi, S. Kim, K. Homan, K. Sokolov, W. Frey, and S. Emelianov, “On stability of molecular therapeutic agents for noninvasive photoacoustic and ultrasound image-guided photothermal therapy,” Proc. SPIE 7564, 75641Q, 75641Q-8 (2010).
[CrossRef]

Y.-S. Chen, W. Frey, S. Kim, K. Homan, P. Kruizinga, K. Sokolov, and S. Emelianov, “Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy,” Opt. Express 18(9), 8867–8878 (2010).
[CrossRef] [PubMed]

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

S. Kumar, J. Aaron, and K. Sokolov, “Directional conjugation of antibodies to nanoparticles for synthesis of multiplexed optical contrast agents with both delivery and targeting moieties,” Nat. Protoc. 3(2), 314–320 (2008).
[CrossRef] [PubMed]

S. Mallidi, T. Larson, J. Aaron, K. Sokolov, and S. Emelianov, “Molecular specific optoacoustic imaging with plasmonic nanoparticles,” Opt. Express 15(11), 6583–6588 (2007).
[CrossRef] [PubMed]

Souris, J. S.

L.-C. Chen, C.-W. Wei, J. S. Souris, S.-H. Cheng, C.-T. Chen, C.-S. Yang, P.-C. Li, and L.-W. Lo, “Enhanced photoacoustic stability of gold nanorods by silica matrix confinement,” J. Biomed. Opt. 15(1), 016010–016016 (2010).
[CrossRef] [PubMed]

Stoica, G.

X. D. Wang, G. Ku, X. Y. Xie, M. A. Wegiel, D. J. Bornhop, G. Stoica, and L. V. Wang, ““Laser-induced photoacoustic tomography enhanced with an optical contrast agent,” Proc. SPIE 5320, 77–82 (2004).
[CrossRef]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[CrossRef] [PubMed]

Suggs, L. J.

L. M. Ricles, S. Y. Nam, K. Sokolov, S. Y. Emelianov, and L. J. Suggs, “Function of mesenchymal stem cells following loading of gold nanotracers,” Int. J. Nanomedicine 6, 407–416 (2011).
[CrossRef] [PubMed]

Tam, J.

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

Tsutsui, S.

S. Tsutsui, S. Ohno, S. Murakami, A. Kataoka, J. Kinoshita, and Y. Hachitanda, “Prognostic value of the combination of epidermal growth factor receptor and c-erbB-2 in breast cancer,” Surgery 133(2), 219–221 (2003).
[CrossRef] [PubMed]

Vandamme, T.

F. Hallouard, N. Anton, P. Choquet, A. Constantinesco, and T. Vandamme, “Iodinated blood pool contrast media for preclinical X-ray imaging applications--a review,” Biomaterials 31(24), 6249–6268 (2010).
[CrossRef] [PubMed]

Visaria, R.

R. Goel, N. Shah, R. Visaria, G. F. Paciotti, and J. C. Bischof, “Biodistribution of TNF-alpha-coated gold nanoparticles in an in vivo model system,” Nanomedicine (Lond) 4(4), 401–410 (2009).
[CrossRef] [PubMed]

Vitolo, D.

R. Bei, G. Pompa, D. Vitolo, E. Moriconi, L. Ciocci, M. Quaranta, L. Frati, M. H. Kraus, and R. Muraro, “Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma,” J. Pathol. 195(3), 343–348 (2001).
[CrossRef] [PubMed]

Wang, C. R. C.

P. C. Li, C. W. Wei, C. K. Liao, C. D. Chen, K. C. Pao, C. R. C. Wang, Y. N. Wu, and D. B. Shieh, “Multiple targeting in photoacoustic imaging using bioconjugated gold nanorods,” Proc. SPIE 6086, 60860M, 60860M-10 (2006).
[CrossRef]

Wang, C.-R. C.

Wang, L. V.

X. D. Wang, G. Ku, X. Y. Xie, M. A. Wegiel, D. J. Bornhop, G. Stoica, and L. V. Wang, ““Laser-induced photoacoustic tomography enhanced with an optical contrast agent,” Proc. SPIE 5320, 77–82 (2004).
[CrossRef]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[CrossRef] [PubMed]

Wang, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[CrossRef] [PubMed]

Wang, X. D.

X. D. Wang, G. Ku, X. Y. Xie, M. A. Wegiel, D. J. Bornhop, G. Stoica, and L. V. Wang, ““Laser-induced photoacoustic tomography enhanced with an optical contrast agent,” Proc. SPIE 5320, 77–82 (2004).
[CrossRef]

Wegiel, M. A.

X. D. Wang, G. Ku, X. Y. Xie, M. A. Wegiel, D. J. Bornhop, G. Stoica, and L. V. Wang, ““Laser-induced photoacoustic tomography enhanced with an optical contrast agent,” Proc. SPIE 5320, 77–82 (2004).
[CrossRef]

Wei, C. W.

P. C. Li, C. W. Wei, C. K. Liao, C. D. Chen, K. C. Pao, C. R. C. Wang, Y. N. Wu, and D. B. Shieh, “Multiple targeting in photoacoustic imaging using bioconjugated gold nanorods,” Proc. SPIE 6086, 60860M, 60860M-10 (2006).
[CrossRef]

Wei, C.-W.

L.-C. Chen, C.-W. Wei, J. S. Souris, S.-H. Cheng, C.-T. Chen, C.-S. Yang, P.-C. Li, and L.-W. Lo, “Enhanced photoacoustic stability of gold nanorods by silica matrix confinement,” J. Biomed. Opt. 15(1), 016010–016016 (2010).
[CrossRef] [PubMed]

P.-C. Li, C.-R. C. Wang, D.-B. Shieh, C.-W. Wei, C.-K. Liao, C. Poe, S. Jhan, A.-A. Ding, and Y.-N. Wu, “In vivo photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods,” Opt. Express 16(23), 18605–18615 (2008).
[CrossRef] [PubMed]

Weissleder, R.

Wiley, H. S.

H. S. Wiley, “Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system,” J. Cell Biol. 107(2), 801–810 (1988).
[CrossRef] [PubMed]

Wu, Y. N.

P. C. Li, C. W. Wei, C. K. Liao, C. D. Chen, K. C. Pao, C. R. C. Wang, Y. N. Wu, and D. B. Shieh, “Multiple targeting in photoacoustic imaging using bioconjugated gold nanorods,” Proc. SPIE 6086, 60860M, 60860M-10 (2006).
[CrossRef]

Wu, Y.-N.

Xie, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[CrossRef] [PubMed]

Xie, X. Y.

X. D. Wang, G. Ku, X. Y. Xie, M. A. Wegiel, D. J. Bornhop, G. Stoica, and L. V. Wang, ““Laser-induced photoacoustic tomography enhanced with an optical contrast agent,” Proc. SPIE 5320, 77–82 (2004).
[CrossRef]

Yang, C.-S.

L.-C. Chen, C.-W. Wei, J. S. Souris, S.-H. Cheng, C.-T. Chen, C.-S. Yang, P.-C. Li, and L.-W. Lo, “Enhanced photoacoustic stability of gold nanorods by silica matrix confinement,” J. Biomed. Opt. 15(1), 016010–016016 (2010).
[CrossRef] [PubMed]

Adv. Mater. (Deerfield Beach Fla.) (1)

N. R. Jana, L. Gearheart, and C. J. Murphy, “Seed-mediated growth approach for shape-controlled synthesis of spheroidal and rod-like gold nanoparticles using a surfactant template,” Adv. Mater. (Deerfield Beach Fla.) 13(18), 1389–1393 (2001).
[CrossRef]

Biomaterials (1)

F. Hallouard, N. Anton, P. Choquet, A. Constantinesco, and T. Vandamme, “Iodinated blood pool contrast media for preclinical X-ray imaging applications--a review,” Biomaterials 31(24), 6249–6268 (2010).
[CrossRef] [PubMed]

Br. J. Cancer (1)

D. M. Abd El-Rehim, S. E. Pinder, C. E. Paish, J. A. Bell, R. S. Rampaul, R. W. Blamey, J. F. R. Robertson, R. I. Nicholson, and I. O. Ellis, “Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma,” Br. J. Cancer 91(8), 1532–1542 (2004).
[CrossRef] [PubMed]

Cancer Res. (1)

M. M. Moasser, A. Basso, S. D. Averbuch, and N. Rosen, “The tyrosine kinase inhibitor ZD1839 (“Iressa”) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells,” Cancer Res. 61(19), 7184–7188 (2001).
[PubMed]

Clin. Cancer Res. (1)

J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, and C. C. Benz, “Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery,” Clin. Cancer Res. 8(4), 1172–1181 (2002).
[PubMed]

Eur. J. Cancer (1)

R. I. Nicholson, J. M. W. Gee, and M. E. Harper, “EGFR and cancer prognosis,” Eur. J. Cancer 37(Suppl 4), 9–15 (2001).
[CrossRef] [PubMed]

Int. J. Nanomedicine (1)

L. M. Ricles, S. Y. Nam, K. Sokolov, S. Y. Emelianov, and L. J. Suggs, “Function of mesenchymal stem cells following loading of gold nanotracers,” Int. J. Nanomedicine 6, 407–416 (2011).
[CrossRef] [PubMed]

J. Biomed. Opt. (1)

L.-C. Chen, C.-W. Wei, J. S. Souris, S.-H. Cheng, C.-T. Chen, C.-S. Yang, P.-C. Li, and L.-W. Lo, “Enhanced photoacoustic stability of gold nanorods by silica matrix confinement,” J. Biomed. Opt. 15(1), 016010–016016 (2010).
[CrossRef] [PubMed]

J. Cell Biol. (2)

H. S. Wiley, “Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system,” J. Cell Biol. 107(2), 801–810 (1988).
[CrossRef] [PubMed]

H. Masui, L. Castro, and J. Mendelsohn, “Consumption of EGF by A431 cells: evidence for receptor recycling,” J. Cell Biol. 120(1), 85–93 (1993).
[CrossRef] [PubMed]

J. Control. Release (1)

S. Dagar, A. Krishnadas, I. Rubinstein, M. J. Blend, and H. Onyüksel, “VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies,” J. Control. Release 91(1-2), 123–133 (2003).
[CrossRef] [PubMed]

J. Nucl. Med. (1)

J. H. Lee, E. L. Rosen, and D. A. Mankoff, “The role of radiotracer imaging in the diagnosis and management of patients with breast cancer: part 1--overview, detection, and staging,” J. Nucl. Med. 50(4), 569–581 (2009).
[CrossRef] [PubMed]

J. Pathol. (1)

R. Bei, G. Pompa, D. Vitolo, E. Moriconi, L. Ciocci, M. Quaranta, L. Frati, M. H. Kraus, and R. Muraro, “Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma,” J. Pathol. 195(3), 343–348 (2001).
[CrossRef] [PubMed]

Med. Phys. (1)

R. A. Kruger, “Photoacoustic ultrasound,” Med. Phys. 21(1), 127–131 (1994).
[CrossRef] [PubMed]

Mol. Biosyst. (1)

R. Alford, M. Ogawa, P. L. Choyke, and H. Kobayashi, “Molecular probes for the in vivo imaging of cancer,” Mol. Biosyst. 5(11), 1279–1291 (2009).
[CrossRef] [PubMed]

Mol. Imaging Biol. (1)

J. A. Copland, M. Eghtedari, V. L. Popov, N. Kotov, N. Mamedova, M. Motamedi, and A. A. Oraevsky, “Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography,” Mol. Imaging Biol. 6(5), 341–349 (2004).
[CrossRef] [PubMed]

Nano Lett. (3)

M. Eghtedari, A. Oraevsky, J. A. Copland, N. A. Kotov, A. Conjusteau, and M. Motamedi, “High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system,” Nano Lett. 7(7), 1914–1918 (2007).
[CrossRef] [PubMed]

Y. S. Chen, W. Frey, S. Kim, P. Kruizinga, K. Homan, and S. Emelianov, “Silica-coated gold nanorods as photoacoustic signal nanoamplifiers,” Nano Lett. 11(2), 348–354 (2011).
[CrossRef] [PubMed]

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

Nanomedicine (Lond) (1)

R. Goel, N. Shah, R. Visaria, G. F. Paciotti, and J. C. Bischof, “Biodistribution of TNF-alpha-coated gold nanoparticles in an in vivo model system,” Nanomedicine (Lond) 4(4), 401–410 (2009).
[CrossRef] [PubMed]

Nat. Biotechnol. (1)

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[CrossRef] [PubMed]

Nat. Protoc. (1)

S. Kumar, J. Aaron, and K. Sokolov, “Directional conjugation of antibodies to nanoparticles for synthesis of multiplexed optical contrast agents with both delivery and targeting moieties,” Nat. Protoc. 3(2), 314–320 (2008).
[CrossRef] [PubMed]

Opt. Express (4)

Opt. Lett. (1)

Proc. Natl. Acad. Sci. U.S.A. (1)

W. Roos, D. Fabbro, W. Küng, S. D. Costa, and U. Eppenberger, “Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cells,” Proc. Natl. Acad. Sci. U.S.A. 83(4), 991–995 (1986).
[CrossRef] [PubMed]

Proc. SPIE (4)

P. C. Li, C. W. Wei, C. K. Liao, C. D. Chen, K. C. Pao, C. R. C. Wang, Y. N. Wu, and D. B. Shieh, “Multiple targeting in photoacoustic imaging using bioconjugated gold nanorods,” Proc. SPIE 6086, 60860M, 60860M-10 (2006).
[CrossRef]

Y. S. Chen, P. Kruizinga, P. P. Joshi, S. Kim, K. Homan, K. Sokolov, W. Frey, and S. Emelianov, “On stability of molecular therapeutic agents for noninvasive photoacoustic and ultrasound image-guided photothermal therapy,” Proc. SPIE 7564, 75641Q, 75641Q-8 (2010).
[CrossRef]

A. A. Oraevsky, A. A. Karabutov, and E. V. Savateeva, “Enhancement of optoacoustic tissue contrast with absorbing nanoparticles,” Proc. SPIE 4434, 60–69 (2001).
[CrossRef]

X. D. Wang, G. Ku, X. Y. Xie, M. A. Wegiel, D. J. Bornhop, G. Stoica, and L. V. Wang, ““Laser-induced photoacoustic tomography enhanced with an optical contrast agent,” Proc. SPIE 5320, 77–82 (2004).
[CrossRef]

Surgery (1)

S. Tsutsui, S. Ohno, S. Murakami, A. Kataoka, J. Kinoshita, and Y. Hachitanda, “Prognostic value of the combination of epidermal growth factor receptor and c-erbB-2 in breast cancer,” Surgery 133(2), 219–221 (2003).
[CrossRef] [PubMed]

Other (3)

“American National Standard for Safe Use of Lasers” (Laser Institute of America, 2007).

A. A. Oraevsky and A. A. Karabutov, Optoacoustic Tomography (CRC Press, 2003).

F. S. Foster, “Micro-ultrasound takes off (In the biological sciences),” in 2008 IEEE International Ultrasonics Symposium (IEEE, 2008), pp. 120–125.

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Figures (4)

Fig. 1
Fig. 1

Custom-built system used to acquire combined US and PA images of cell phantom.

Fig. 2
Fig. 2

Characterization of multiplex SiO2-AuNRs. TEM images showing the size of the as-synthesized SiO2-AuNRs (prior to bioconjugation) with peak optical absorbances of 780 nm (a) and 830 nm (b). UV-Vis spectra showing the peak optical absorption of the targeted SiO2-AuNRs are shown in (c) and (d).

Fig. 3
Fig. 3

Optical microscopy images demonstrating enhanced uptake of targeted silica-coated gold nanorods (SiO2-AuNRs). a) SiO2-AuNRs targeted to the EGFR receptor are uptaken in greater amounts in A431 cells in comparison to b) non-targeted SiO2-AuNRs with an identical aspect ratio. Likewise, d) SiO2-AuNRs targeted to the EGFR show increased uptake in A431 cells in comparison to e) non-targeted SiO2-AuNRs. Cells which have not been exposed to SiO2-AuNRs are shown in panel c) and panel f) as controls. Images obtained using a 20 × objective (0.5 NA) and Leica 6000 DM microscope.

Fig. 4
Fig. 4

Signal processing and statistical analysis of the PA images acquired from the cell phantoms demonstrates the unique identification of the cell inclusions. a) The inclusions can be seen in the ultrasound image. b) The PA image, acquired at 830 nm, indicates which inclusions contain SiO2-AuNRs. c) Comparison of PA signal intensity (points) and UV-VIS spectra (solid lines) demonstrates that the SiO2-AuNRs optical absorption spectra determine the PA signal intensity. Inclusions were segmented into three areas and the PA signal intensity was averaged; error bars represent one standard deviation (n = 3). d) Molecular map of cells and US overlay; 830 nm SiO2-AuNRs are shown in red, 780 nm SiO2-AuNRs are shown in yellow (ICC > 0.75). FOV = 3.5 mm x 53 mm, US image dynamic range = 35 dB, PA image dynamic range = 10 dB.

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