Abstract

The location of the loss of the inner segment (IS)/outer segment (OS) border, as seen with frequency domain optical coherence tomography (fdOCT), was determined on fdOCT scans from patients with retinitis pigmentosa. A comparison to visual field loss supported the hypothesis, based upon previous work, that the point at which the IS/OS border disappears provides a structural marker for the edge of the visual field. Repeat fdOCT measures showed good within day reproducibility, while data obtained on average 22.5 months later showed signs of progression. The IS/OS contour shows promise as a measure for following changes in patients undergoing treatment.

© 2011 OSA

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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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2011

D. C. Hood, M. A. Lazow, K. G. Locke, V. C. Greenstein, and D. G. Birch, “The transition zone between healthy and diseased retina in patients with retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 52(1), 101–108 (2011).
[CrossRef] [PubMed]

D. C. Hood, J. Cho, A. S. Raza, E. A. Dale, and M. Wang, “Reliability of a computer-aided manual procedure for segmenting optical coherence tomography scans,” Optom. Vis. Sci. 88(1), 113–123 (2011).
[CrossRef] [PubMed]

2010

R. S. Jonnal, J. R. Besecker, J. C. Derby, O. P. Kocaoglu, B. Cense, W. Gao, Q. Wang, and D. T. Miller, “Imaging outer segment renewal in living human cone photoreceptors,” Opt. Express 18(5), 5257–5270 (2010).
[CrossRef] [PubMed]

N. V. Rangaswamy, H. M. Patel, K. G. Locke, D. C. Hood, and D. G. Birch, “A comparison of visual field sensitivity to photoreceptor thickness in retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 51(8), 4213–4219 (2010).
[CrossRef] [PubMed]

2009

D. C. Hood, C. E. Lin, M. A. Lazow, K. G. Locke, X. Zhang, and D. G. Birch, “Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 50(5), 2328–2336 (2009).
[CrossRef] [PubMed]

A. Oishi, A. Otani, M. Sasahara, H. Kojima, H. Nakamura, M. Kurimoto, and N. Yoshimura, “Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa,” Eye (Lond.) 23(6), 1411–1416 (2009).
[CrossRef] [PubMed]

S. Aizawa, Y. Mitamura, T. Baba, A. Hagiwara, K. Ogata, and S. Yamamoto, “Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa,” Eye (Lond.) 23(2), 304–308 (2009).
[CrossRef] [PubMed]

S. G. Jacobson, T. S. Aleman, A. Sumaroka, A. V. Cideciyan, A. J. Roman, E. A. Windsor, S. B. Schwartz, H. L. Rehm, and W. J. Kimberling, “Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations,” Invest. Ophthalmol. Vis. Sci. 50(4), 1886–1894 (2009).
[CrossRef] [PubMed]

2008

S. G. Jacobson, A. V. Cideciyan, T. S. Aleman, A. Sumaroka, E. A. Windsor, S. B. Schwartz, E. Heon, and E. M. Stone, “Photoreceptor layer topography in children with leber congenital amaurosis caused by RPE65 mutations,” Invest. Ophthalmol. Vis. Sci. 49(10), 4573–4577 (2008).
[CrossRef] [PubMed]

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

M. D. Fischer, J. C. Fleischhauer, M. C. Gillies, F. K. Sutter, H. Helbig, and D. Barthelmes, “A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 49(8), 3617–3621 (2008).
[CrossRef] [PubMed]

E. J. Fernández, B. Hermann, B. Povazay, A. Unterhuber, H. Sattmann, B. Hofer, P. K. Ahnelt, and W. Drexler, “Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina,” Opt. Express 16(15), 11083–11094 (2008).
[CrossRef] [PubMed]

L. K. Chang, H. Koizumi, and R. F. Spaide, “Disruption of the photoreceptor inner segment-outer segment junction in eyes with macular holes,” Retina 28(7), 969–975 (2008).
[CrossRef] [PubMed]

2007

M. A. Apushkin, G. A. Fishman, K. R. Alexander, and M. Shahidi, “Retinal thickness and visual thresholds measured in patients with retinitis pigmentosa,” Retina 27(3), 349–357 (2007).
[CrossRef] [PubMed]

Ahnelt, P. K.

Aizawa, S.

S. Aizawa, Y. Mitamura, T. Baba, A. Hagiwara, K. Ogata, and S. Yamamoto, “Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa,” Eye (Lond.) 23(2), 304–308 (2009).
[CrossRef] [PubMed]

Aleman, T. S.

S. G. Jacobson, T. S. Aleman, A. Sumaroka, A. V. Cideciyan, A. J. Roman, E. A. Windsor, S. B. Schwartz, H. L. Rehm, and W. J. Kimberling, “Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations,” Invest. Ophthalmol. Vis. Sci. 50(4), 1886–1894 (2009).
[CrossRef] [PubMed]

S. G. Jacobson, A. V. Cideciyan, T. S. Aleman, A. Sumaroka, E. A. Windsor, S. B. Schwartz, E. Heon, and E. M. Stone, “Photoreceptor layer topography in children with leber congenital amaurosis caused by RPE65 mutations,” Invest. Ophthalmol. Vis. Sci. 49(10), 4573–4577 (2008).
[CrossRef] [PubMed]

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

Alexander, K. R.

M. A. Apushkin, G. A. Fishman, K. R. Alexander, and M. Shahidi, “Retinal thickness and visual thresholds measured in patients with retinitis pigmentosa,” Retina 27(3), 349–357 (2007).
[CrossRef] [PubMed]

Apushkin, M. A.

M. A. Apushkin, G. A. Fishman, K. R. Alexander, and M. Shahidi, “Retinal thickness and visual thresholds measured in patients with retinitis pigmentosa,” Retina 27(3), 349–357 (2007).
[CrossRef] [PubMed]

Baba, T.

S. Aizawa, Y. Mitamura, T. Baba, A. Hagiwara, K. Ogata, and S. Yamamoto, “Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa,” Eye (Lond.) 23(2), 304–308 (2009).
[CrossRef] [PubMed]

Barthelmes, D.

M. D. Fischer, J. C. Fleischhauer, M. C. Gillies, F. K. Sutter, H. Helbig, and D. Barthelmes, “A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 49(8), 3617–3621 (2008).
[CrossRef] [PubMed]

Besecker, J. R.

Birch, D. G.

D. C. Hood, M. A. Lazow, K. G. Locke, V. C. Greenstein, and D. G. Birch, “The transition zone between healthy and diseased retina in patients with retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 52(1), 101–108 (2011).
[CrossRef] [PubMed]

N. V. Rangaswamy, H. M. Patel, K. G. Locke, D. C. Hood, and D. G. Birch, “A comparison of visual field sensitivity to photoreceptor thickness in retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 51(8), 4213–4219 (2010).
[CrossRef] [PubMed]

D. C. Hood, C. E. Lin, M. A. Lazow, K. G. Locke, X. Zhang, and D. G. Birch, “Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 50(5), 2328–2336 (2009).
[CrossRef] [PubMed]

Cense, B.

Chang, L. K.

L. K. Chang, H. Koizumi, and R. F. Spaide, “Disruption of the photoreceptor inner segment-outer segment junction in eyes with macular holes,” Retina 28(7), 969–975 (2008).
[CrossRef] [PubMed]

Cho, J.

D. C. Hood, J. Cho, A. S. Raza, E. A. Dale, and M. Wang, “Reliability of a computer-aided manual procedure for segmenting optical coherence tomography scans,” Optom. Vis. Sci. 88(1), 113–123 (2011).
[CrossRef] [PubMed]

Cideciyan, A. V.

S. G. Jacobson, T. S. Aleman, A. Sumaroka, A. V. Cideciyan, A. J. Roman, E. A. Windsor, S. B. Schwartz, H. L. Rehm, and W. J. Kimberling, “Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations,” Invest. Ophthalmol. Vis. Sci. 50(4), 1886–1894 (2009).
[CrossRef] [PubMed]

S. G. Jacobson, A. V. Cideciyan, T. S. Aleman, A. Sumaroka, E. A. Windsor, S. B. Schwartz, E. Heon, and E. M. Stone, “Photoreceptor layer topography in children with leber congenital amaurosis caused by RPE65 mutations,” Invest. Ophthalmol. Vis. Sci. 49(10), 4573–4577 (2008).
[CrossRef] [PubMed]

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

Dale, E. A.

D. C. Hood, J. Cho, A. S. Raza, E. A. Dale, and M. Wang, “Reliability of a computer-aided manual procedure for segmenting optical coherence tomography scans,” Optom. Vis. Sci. 88(1), 113–123 (2011).
[CrossRef] [PubMed]

Derby, J. C.

Drexler, W.

Fernández, E. J.

Fischer, M. D.

M. D. Fischer, J. C. Fleischhauer, M. C. Gillies, F. K. Sutter, H. Helbig, and D. Barthelmes, “A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 49(8), 3617–3621 (2008).
[CrossRef] [PubMed]

Fishman, G. A.

M. A. Apushkin, G. A. Fishman, K. R. Alexander, and M. Shahidi, “Retinal thickness and visual thresholds measured in patients with retinitis pigmentosa,” Retina 27(3), 349–357 (2007).
[CrossRef] [PubMed]

Fleischhauer, J. C.

M. D. Fischer, J. C. Fleischhauer, M. C. Gillies, F. K. Sutter, H. Helbig, and D. Barthelmes, “A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 49(8), 3617–3621 (2008).
[CrossRef] [PubMed]

Gao, W.

Gillies, M. C.

M. D. Fischer, J. C. Fleischhauer, M. C. Gillies, F. K. Sutter, H. Helbig, and D. Barthelmes, “A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 49(8), 3617–3621 (2008).
[CrossRef] [PubMed]

Greenstein, V. C.

D. C. Hood, M. A. Lazow, K. G. Locke, V. C. Greenstein, and D. G. Birch, “The transition zone between healthy and diseased retina in patients with retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 52(1), 101–108 (2011).
[CrossRef] [PubMed]

Hagiwara, A.

S. Aizawa, Y. Mitamura, T. Baba, A. Hagiwara, K. Ogata, and S. Yamamoto, “Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa,” Eye (Lond.) 23(2), 304–308 (2009).
[CrossRef] [PubMed]

Helbig, H.

M. D. Fischer, J. C. Fleischhauer, M. C. Gillies, F. K. Sutter, H. Helbig, and D. Barthelmes, “A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 49(8), 3617–3621 (2008).
[CrossRef] [PubMed]

Heon, E.

S. G. Jacobson, A. V. Cideciyan, T. S. Aleman, A. Sumaroka, E. A. Windsor, S. B. Schwartz, E. Heon, and E. M. Stone, “Photoreceptor layer topography in children with leber congenital amaurosis caused by RPE65 mutations,” Invest. Ophthalmol. Vis. Sci. 49(10), 4573–4577 (2008).
[CrossRef] [PubMed]

Hermann, B.

Herrera, W.

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

Hofer, B.

Hood, D. C.

D. C. Hood, J. Cho, A. S. Raza, E. A. Dale, and M. Wang, “Reliability of a computer-aided manual procedure for segmenting optical coherence tomography scans,” Optom. Vis. Sci. 88(1), 113–123 (2011).
[CrossRef] [PubMed]

D. C. Hood, M. A. Lazow, K. G. Locke, V. C. Greenstein, and D. G. Birch, “The transition zone between healthy and diseased retina in patients with retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 52(1), 101–108 (2011).
[CrossRef] [PubMed]

N. V. Rangaswamy, H. M. Patel, K. G. Locke, D. C. Hood, and D. G. Birch, “A comparison of visual field sensitivity to photoreceptor thickness in retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 51(8), 4213–4219 (2010).
[CrossRef] [PubMed]

D. C. Hood, C. E. Lin, M. A. Lazow, K. G. Locke, X. Zhang, and D. G. Birch, “Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 50(5), 2328–2336 (2009).
[CrossRef] [PubMed]

Jacobson, S. G.

S. G. Jacobson, T. S. Aleman, A. Sumaroka, A. V. Cideciyan, A. J. Roman, E. A. Windsor, S. B. Schwartz, H. L. Rehm, and W. J. Kimberling, “Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations,” Invest. Ophthalmol. Vis. Sci. 50(4), 1886–1894 (2009).
[CrossRef] [PubMed]

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

S. G. Jacobson, A. V. Cideciyan, T. S. Aleman, A. Sumaroka, E. A. Windsor, S. B. Schwartz, E. Heon, and E. M. Stone, “Photoreceptor layer topography in children with leber congenital amaurosis caused by RPE65 mutations,” Invest. Ophthalmol. Vis. Sci. 49(10), 4573–4577 (2008).
[CrossRef] [PubMed]

Jonnal, R. S.

Kaushal, S.

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

Kimberling, W. J.

S. G. Jacobson, T. S. Aleman, A. Sumaroka, A. V. Cideciyan, A. J. Roman, E. A. Windsor, S. B. Schwartz, H. L. Rehm, and W. J. Kimberling, “Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations,” Invest. Ophthalmol. Vis. Sci. 50(4), 1886–1894 (2009).
[CrossRef] [PubMed]

Kocaoglu, O. P.

Koizumi, H.

L. K. Chang, H. Koizumi, and R. F. Spaide, “Disruption of the photoreceptor inner segment-outer segment junction in eyes with macular holes,” Retina 28(7), 969–975 (2008).
[CrossRef] [PubMed]

Kojima, H.

A. Oishi, A. Otani, M. Sasahara, H. Kojima, H. Nakamura, M. Kurimoto, and N. Yoshimura, “Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa,” Eye (Lond.) 23(6), 1411–1416 (2009).
[CrossRef] [PubMed]

Kurimoto, M.

A. Oishi, A. Otani, M. Sasahara, H. Kojima, H. Nakamura, M. Kurimoto, and N. Yoshimura, “Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa,” Eye (Lond.) 23(6), 1411–1416 (2009).
[CrossRef] [PubMed]

Lazow, M. A.

D. C. Hood, M. A. Lazow, K. G. Locke, V. C. Greenstein, and D. G. Birch, “The transition zone between healthy and diseased retina in patients with retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 52(1), 101–108 (2011).
[CrossRef] [PubMed]

D. C. Hood, C. E. Lin, M. A. Lazow, K. G. Locke, X. Zhang, and D. G. Birch, “Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 50(5), 2328–2336 (2009).
[CrossRef] [PubMed]

Lin, C. E.

D. C. Hood, C. E. Lin, M. A. Lazow, K. G. Locke, X. Zhang, and D. G. Birch, “Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 50(5), 2328–2336 (2009).
[CrossRef] [PubMed]

Locke, K. G.

D. C. Hood, M. A. Lazow, K. G. Locke, V. C. Greenstein, and D. G. Birch, “The transition zone between healthy and diseased retina in patients with retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 52(1), 101–108 (2011).
[CrossRef] [PubMed]

N. V. Rangaswamy, H. M. Patel, K. G. Locke, D. C. Hood, and D. G. Birch, “A comparison of visual field sensitivity to photoreceptor thickness in retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 51(8), 4213–4219 (2010).
[CrossRef] [PubMed]

D. C. Hood, C. E. Lin, M. A. Lazow, K. G. Locke, X. Zhang, and D. G. Birch, “Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 50(5), 2328–2336 (2009).
[CrossRef] [PubMed]

Miller, D. T.

Mitamura, Y.

S. Aizawa, Y. Mitamura, T. Baba, A. Hagiwara, K. Ogata, and S. Yamamoto, “Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa,” Eye (Lond.) 23(2), 304–308 (2009).
[CrossRef] [PubMed]

Naidu, A.

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

Nakamura, H.

A. Oishi, A. Otani, M. Sasahara, H. Kojima, H. Nakamura, M. Kurimoto, and N. Yoshimura, “Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa,” Eye (Lond.) 23(6), 1411–1416 (2009).
[CrossRef] [PubMed]

Ogata, K.

S. Aizawa, Y. Mitamura, T. Baba, A. Hagiwara, K. Ogata, and S. Yamamoto, “Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa,” Eye (Lond.) 23(2), 304–308 (2009).
[CrossRef] [PubMed]

Oishi, A.

A. Oishi, A. Otani, M. Sasahara, H. Kojima, H. Nakamura, M. Kurimoto, and N. Yoshimura, “Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa,” Eye (Lond.) 23(6), 1411–1416 (2009).
[CrossRef] [PubMed]

Otani, A.

A. Oishi, A. Otani, M. Sasahara, H. Kojima, H. Nakamura, M. Kurimoto, and N. Yoshimura, “Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa,” Eye (Lond.) 23(6), 1411–1416 (2009).
[CrossRef] [PubMed]

Patel, H. M.

N. V. Rangaswamy, H. M. Patel, K. G. Locke, D. C. Hood, and D. G. Birch, “A comparison of visual field sensitivity to photoreceptor thickness in retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 51(8), 4213–4219 (2010).
[CrossRef] [PubMed]

Povazay, B.

Rangaswamy, N. V.

N. V. Rangaswamy, H. M. Patel, K. G. Locke, D. C. Hood, and D. G. Birch, “A comparison of visual field sensitivity to photoreceptor thickness in retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 51(8), 4213–4219 (2010).
[CrossRef] [PubMed]

Raza, A. S.

D. C. Hood, J. Cho, A. S. Raza, E. A. Dale, and M. Wang, “Reliability of a computer-aided manual procedure for segmenting optical coherence tomography scans,” Optom. Vis. Sci. 88(1), 113–123 (2011).
[CrossRef] [PubMed]

Rehm, H. L.

S. G. Jacobson, T. S. Aleman, A. Sumaroka, A. V. Cideciyan, A. J. Roman, E. A. Windsor, S. B. Schwartz, H. L. Rehm, and W. J. Kimberling, “Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations,” Invest. Ophthalmol. Vis. Sci. 50(4), 1886–1894 (2009).
[CrossRef] [PubMed]

Roman, A. J.

S. G. Jacobson, T. S. Aleman, A. Sumaroka, A. V. Cideciyan, A. J. Roman, E. A. Windsor, S. B. Schwartz, H. L. Rehm, and W. J. Kimberling, “Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations,” Invest. Ophthalmol. Vis. Sci. 50(4), 1886–1894 (2009).
[CrossRef] [PubMed]

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

Sasahara, M.

A. Oishi, A. Otani, M. Sasahara, H. Kojima, H. Nakamura, M. Kurimoto, and N. Yoshimura, “Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa,” Eye (Lond.) 23(6), 1411–1416 (2009).
[CrossRef] [PubMed]

Sattmann, H.

Schwartz, S. B.

S. G. Jacobson, T. S. Aleman, A. Sumaroka, A. V. Cideciyan, A. J. Roman, E. A. Windsor, S. B. Schwartz, H. L. Rehm, and W. J. Kimberling, “Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations,” Invest. Ophthalmol. Vis. Sci. 50(4), 1886–1894 (2009).
[CrossRef] [PubMed]

S. G. Jacobson, A. V. Cideciyan, T. S. Aleman, A. Sumaroka, E. A. Windsor, S. B. Schwartz, E. Heon, and E. M. Stone, “Photoreceptor layer topography in children with leber congenital amaurosis caused by RPE65 mutations,” Invest. Ophthalmol. Vis. Sci. 49(10), 4573–4577 (2008).
[CrossRef] [PubMed]

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

Shahidi, M.

M. A. Apushkin, G. A. Fishman, K. R. Alexander, and M. Shahidi, “Retinal thickness and visual thresholds measured in patients with retinitis pigmentosa,” Retina 27(3), 349–357 (2007).
[CrossRef] [PubMed]

Spaide, R. F.

L. K. Chang, H. Koizumi, and R. F. Spaide, “Disruption of the photoreceptor inner segment-outer segment junction in eyes with macular holes,” Retina 28(7), 969–975 (2008).
[CrossRef] [PubMed]

Stone, E. M.

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

S. G. Jacobson, A. V. Cideciyan, T. S. Aleman, A. Sumaroka, E. A. Windsor, S. B. Schwartz, E. Heon, and E. M. Stone, “Photoreceptor layer topography in children with leber congenital amaurosis caused by RPE65 mutations,” Invest. Ophthalmol. Vis. Sci. 49(10), 4573–4577 (2008).
[CrossRef] [PubMed]

Sumaroka, A.

S. G. Jacobson, T. S. Aleman, A. Sumaroka, A. V. Cideciyan, A. J. Roman, E. A. Windsor, S. B. Schwartz, H. L. Rehm, and W. J. Kimberling, “Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations,” Invest. Ophthalmol. Vis. Sci. 50(4), 1886–1894 (2009).
[CrossRef] [PubMed]

S. G. Jacobson, A. V. Cideciyan, T. S. Aleman, A. Sumaroka, E. A. Windsor, S. B. Schwartz, E. Heon, and E. M. Stone, “Photoreceptor layer topography in children with leber congenital amaurosis caused by RPE65 mutations,” Invest. Ophthalmol. Vis. Sci. 49(10), 4573–4577 (2008).
[CrossRef] [PubMed]

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

Sutter, F. K.

M. D. Fischer, J. C. Fleischhauer, M. C. Gillies, F. K. Sutter, H. Helbig, and D. Barthelmes, “A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 49(8), 3617–3621 (2008).
[CrossRef] [PubMed]

Unterhuber, A.

Wang, M.

D. C. Hood, J. Cho, A. S. Raza, E. A. Dale, and M. Wang, “Reliability of a computer-aided manual procedure for segmenting optical coherence tomography scans,” Optom. Vis. Sci. 88(1), 113–123 (2011).
[CrossRef] [PubMed]

Wang, Q.

White, D. A.

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

Windsor, E. A.

S. G. Jacobson, T. S. Aleman, A. Sumaroka, A. V. Cideciyan, A. J. Roman, E. A. Windsor, S. B. Schwartz, H. L. Rehm, and W. J. Kimberling, “Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations,” Invest. Ophthalmol. Vis. Sci. 50(4), 1886–1894 (2009).
[CrossRef] [PubMed]

S. G. Jacobson, A. V. Cideciyan, T. S. Aleman, A. Sumaroka, E. A. Windsor, S. B. Schwartz, E. Heon, and E. M. Stone, “Photoreceptor layer topography in children with leber congenital amaurosis caused by RPE65 mutations,” Invest. Ophthalmol. Vis. Sci. 49(10), 4573–4577 (2008).
[CrossRef] [PubMed]

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

Yamamoto, S.

S. Aizawa, Y. Mitamura, T. Baba, A. Hagiwara, K. Ogata, and S. Yamamoto, “Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa,” Eye (Lond.) 23(2), 304–308 (2009).
[CrossRef] [PubMed]

Yoshimura, N.

A. Oishi, A. Otani, M. Sasahara, H. Kojima, H. Nakamura, M. Kurimoto, and N. Yoshimura, “Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa,” Eye (Lond.) 23(6), 1411–1416 (2009).
[CrossRef] [PubMed]

Zhang, X.

D. C. Hood, C. E. Lin, M. A. Lazow, K. G. Locke, X. Zhang, and D. G. Birch, “Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 50(5), 2328–2336 (2009).
[CrossRef] [PubMed]

Eye (Lond.)

A. Oishi, A. Otani, M. Sasahara, H. Kojima, H. Nakamura, M. Kurimoto, and N. Yoshimura, “Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa,” Eye (Lond.) 23(6), 1411–1416 (2009).
[CrossRef] [PubMed]

S. Aizawa, Y. Mitamura, T. Baba, A. Hagiwara, K. Ogata, and S. Yamamoto, “Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa,” Eye (Lond.) 23(2), 304–308 (2009).
[CrossRef] [PubMed]

Invest. Ophthalmol. Vis. Sci.

M. D. Fischer, J. C. Fleischhauer, M. C. Gillies, F. K. Sutter, H. Helbig, and D. Barthelmes, “A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 49(8), 3617–3621 (2008).
[CrossRef] [PubMed]

D. C. Hood, C. E. Lin, M. A. Lazow, K. G. Locke, X. Zhang, and D. G. Birch, “Thickness of receptor and post-receptor retinal layers in patients with retinitis pigmentosa measured with frequency-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 50(5), 2328–2336 (2009).
[CrossRef] [PubMed]

T. S. Aleman, A. V. Cideciyan, A. Sumaroka, E. A. Windsor, W. Herrera, D. A. White, S. Kaushal, A. Naidu, A. J. Roman, S. B. Schwartz, E. M. Stone, and S. G. Jacobson, “Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations,” Invest. Ophthalmol. Vis. Sci. 49(4), 1580–1590 (2008).
[CrossRef] [PubMed]

S. G. Jacobson, T. S. Aleman, A. Sumaroka, A. V. Cideciyan, A. J. Roman, E. A. Windsor, S. B. Schwartz, H. L. Rehm, and W. J. Kimberling, “Disease boundaries in the retina of patients with Usher syndrome caused by MYO7A gene mutations,” Invest. Ophthalmol. Vis. Sci. 50(4), 1886–1894 (2009).
[CrossRef] [PubMed]

S. G. Jacobson, A. V. Cideciyan, T. S. Aleman, A. Sumaroka, E. A. Windsor, S. B. Schwartz, E. Heon, and E. M. Stone, “Photoreceptor layer topography in children with leber congenital amaurosis caused by RPE65 mutations,” Invest. Ophthalmol. Vis. Sci. 49(10), 4573–4577 (2008).
[CrossRef] [PubMed]

N. V. Rangaswamy, H. M. Patel, K. G. Locke, D. C. Hood, and D. G. Birch, “A comparison of visual field sensitivity to photoreceptor thickness in retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 51(8), 4213–4219 (2010).
[CrossRef] [PubMed]

D. C. Hood, M. A. Lazow, K. G. Locke, V. C. Greenstein, and D. G. Birch, “The transition zone between healthy and diseased retina in patients with retinitis pigmentosa,” Invest. Ophthalmol. Vis. Sci. 52(1), 101–108 (2011).
[CrossRef] [PubMed]

Opt. Express

Optom. Vis. Sci.

D. C. Hood, J. Cho, A. S. Raza, E. A. Dale, and M. Wang, “Reliability of a computer-aided manual procedure for segmenting optical coherence tomography scans,” Optom. Vis. Sci. 88(1), 113–123 (2011).
[CrossRef] [PubMed]

Retina

L. K. Chang, H. Koizumi, and R. F. Spaide, “Disruption of the photoreceptor inner segment-outer segment junction in eyes with macular holes,” Retina 28(7), 969–975 (2008).
[CrossRef] [PubMed]

M. A. Apushkin, G. A. Fishman, K. R. Alexander, and M. Shahidi, “Retinal thickness and visual thresholds measured in patients with retinitis pigmentosa,” Retina 27(3), 349–357 (2007).
[CrossRef] [PubMed]

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Figures (5)

Fig. 1
Fig. 1

fdOCT scan through the horizontal meridian of P1. (a) Scan before segmentation. (b) Scan after segmentation of IS/OS (red) and OS/RPE (green) boundaries. (c) Expanded view of portion within white rectangle in panel (b).

Fig. 2
Fig. 2

An illustration of the procedure for estimating the end of the IS/OS border using the horizontal scan for P1 shown in Fig. 1. (a) The 10-2 total deviation plot. (b) Same as panel A with the location of the scans segmented. (c) The thickness of the OS layer as a function of distance across the scan shown in Fig. 1. The dashed lines indicate zero OS thickness (horizontal) and the center of the fovea (vertical).

Fig. 3
Fig. 3

IS/OS contours and visual fields. A dashed line was used where the exact location of the IS/OS disappearance was uncertain due to the sparse vertical spacing of the segmented scans. (a) The 10-2 visual field losses (total deviation in dB) are shown with the boundary (red curve) of the IS/OS loss for patient P1. Visual field losses of −10 or worse are shown in red. (b)-(f). Same as in (a) for the other 5 patients.

Fig. 4
Fig. 4

Repeat measures within and across sessions. In each panel, the red and green curves show the 2 scans performed on the first (red) and second (green) visits. Black circles indicate the location of the 10-2 points and the numbers (in dB) show the change in field sensitivity (in dB) between the 2 visits (visit 2-visit 1).

Fig. 5
Fig. 5

OS thickness versus field loss. The thickness of the OS at each point in the visual field is shown for individual patients (small symbols) as a function of the field loss at that point. The large symbols are the means of the data grouped into equal sized bins.

Tables (1)

Tables Icon

Table 1 Patient characteristics a

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