Abstract

To relate structural (anatomical) and functional (behavioral) measures of glaucomatous damage, a method is described for comparing visual field defects to local retinal ganglion cell (RGC) and retinal nerve fiber layer (RNFL) thicknesses. Thickness maps of the RNFL and the RGC + inner plexiform layer, obtained with frequency domain optical coherence tomography (fdOCT), were transformed into probability maps by comparing them to a normative group. As demonstrated in patients with glaucomatous damage to the macula, the probability map associated with the patient’s visual field can be directly compared to the fdOCT probability maps by taking into consideration the displacement of the RGCs.

© 2011 OSA

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  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
    [CrossRef] [PubMed]
  2. J. S. Schuman, M. R. Hee, A. V. Arya, T. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. A. Swanson, “Optical coherence tomography: a new tool for glaucoma diagnosis,” Curr. Opin. Ophthalmol. 6(2), 89–95 (1995).
    [PubMed]
  3. M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, C. V. De Moraes, X. Zhang, R. Ritch, and J. M. Liebmann, “Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography,” Arch. Ophthalmol. 127(7), 875–881 (2009).
    [CrossRef] [PubMed]
  4. O. Tan, V. Chopra, A. T. Lu, J. S. Schuman, H. Ishikawa, G. Wollstein, R. Varma, and D. Huang, “Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography,” Ophthalmology 116(12), 2305–2314.e2, (2009).
    [CrossRef] [PubMed]
  5. A. S. Raza, J. Cho, C. G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, and D. C. Hood, “Macular retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma,” Arch. Ophthalmol. (to be published).
  6. N. R. Kim, E. S. Lee, G. J. Seong, J. H. Kim, H. G. An, and C. Y. Kim, “Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma,” Invest. Ophthalmol. Vis. Sci. 51(9), 4646–4651 (2010).
    [CrossRef] [PubMed]
  7. J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010).
    [CrossRef] [PubMed]
  8. D. C. Hood, A. S. Raza, C. G. V. de Moraes, J. G. Odel, V. C. Greenstein, J. M. Liebmann, and R. Ritch, “Initial arcuate defects within the central 10 degrees in glaucoma,” Invest. Ophthalmol. Vis. Sci. 52(2), 940–946 (2011).
    [CrossRef] [PubMed]
  9. Q. Yang, C. A. Reisman, Z. Wang, Y. Fukuma, M. Hangai, N. Yoshimura, A. Tomidokoro, M. Araie, A. S. Raza, D. C. Hood, and K. Chan, “Automated layer segmentation of macular OCT images using dual-scale gradient information,” Opt. Express 18(20), 21293–21307 (2010).
    [CrossRef] [PubMed]
  10. N. Drasdo, C. L. Millican, C. R. Katholi, and C. A. Curcio, “The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field,” Vision Res. 47(22), 2901–2911 (2007).
    [CrossRef] [PubMed]
  11. D. C. Hood and V. C. Greenstein, “Multifocal VEP and ganglion cell damage: applications and limitations for the study of glaucoma,” Prog. Retin. Eye Res. 22(2), 201–251 (2003).
    [CrossRef] [PubMed]

2011 (1)

D. C. Hood, A. S. Raza, C. G. V. de Moraes, J. G. Odel, V. C. Greenstein, J. M. Liebmann, and R. Ritch, “Initial arcuate defects within the central 10 degrees in glaucoma,” Invest. Ophthalmol. Vis. Sci. 52(2), 940–946 (2011).
[CrossRef] [PubMed]

2010 (3)

N. R. Kim, E. S. Lee, G. J. Seong, J. H. Kim, H. G. An, and C. Y. Kim, “Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma,” Invest. Ophthalmol. Vis. Sci. 51(9), 4646–4651 (2010).
[CrossRef] [PubMed]

J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010).
[CrossRef] [PubMed]

Q. Yang, C. A. Reisman, Z. Wang, Y. Fukuma, M. Hangai, N. Yoshimura, A. Tomidokoro, M. Araie, A. S. Raza, D. C. Hood, and K. Chan, “Automated layer segmentation of macular OCT images using dual-scale gradient information,” Opt. Express 18(20), 21293–21307 (2010).
[CrossRef] [PubMed]

2009 (2)

M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, C. V. De Moraes, X. Zhang, R. Ritch, and J. M. Liebmann, “Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography,” Arch. Ophthalmol. 127(7), 875–881 (2009).
[CrossRef] [PubMed]

O. Tan, V. Chopra, A. T. Lu, J. S. Schuman, H. Ishikawa, G. Wollstein, R. Varma, and D. Huang, “Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography,” Ophthalmology 116(12), 2305–2314.e2, (2009).
[CrossRef] [PubMed]

2007 (1)

N. Drasdo, C. L. Millican, C. R. Katholi, and C. A. Curcio, “The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field,” Vision Res. 47(22), 2901–2911 (2007).
[CrossRef] [PubMed]

2003 (1)

D. C. Hood and V. C. Greenstein, “Multifocal VEP and ganglion cell damage: applications and limitations for the study of glaucoma,” Prog. Retin. Eye Res. 22(2), 201–251 (2003).
[CrossRef] [PubMed]

1995 (1)

J. S. Schuman, M. R. Hee, A. V. Arya, T. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. A. Swanson, “Optical coherence tomography: a new tool for glaucoma diagnosis,” Curr. Opin. Ophthalmol. 6(2), 89–95 (1995).
[PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

An, H. G.

N. R. Kim, E. S. Lee, G. J. Seong, J. H. Kim, H. G. An, and C. Y. Kim, “Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma,” Invest. Ophthalmol. Vis. Sci. 51(9), 4646–4651 (2010).
[CrossRef] [PubMed]

Araie, M.

Arya, A. V.

J. S. Schuman, M. R. Hee, A. V. Arya, T. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. A. Swanson, “Optical coherence tomography: a new tool for glaucoma diagnosis,” Curr. Opin. Ophthalmol. 6(2), 89–95 (1995).
[PubMed]

Chan, K.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Cho, J.

A. S. Raza, J. Cho, C. G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, and D. C. Hood, “Macular retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma,” Arch. Ophthalmol. (to be published).

Cho, J. W.

J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010).
[CrossRef] [PubMed]

Cho, J.-S.

M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, C. V. De Moraes, X. Zhang, R. Ritch, and J. M. Liebmann, “Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography,” Arch. Ophthalmol. 127(7), 875–881 (2009).
[CrossRef] [PubMed]

Choi, J.

J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010).
[CrossRef] [PubMed]

Chopra, V.

O. Tan, V. Chopra, A. T. Lu, J. S. Schuman, H. Ishikawa, G. Wollstein, R. Varma, and D. Huang, “Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography,” Ophthalmology 116(12), 2305–2314.e2, (2009).
[CrossRef] [PubMed]

Curcio, C. A.

N. Drasdo, C. L. Millican, C. R. Katholi, and C. A. Curcio, “The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field,” Vision Res. 47(22), 2901–2911 (2007).
[CrossRef] [PubMed]

de Moraes, C. G. V.

D. C. Hood, A. S. Raza, C. G. V. de Moraes, J. G. Odel, V. C. Greenstein, J. M. Liebmann, and R. Ritch, “Initial arcuate defects within the central 10 degrees in glaucoma,” Invest. Ophthalmol. Vis. Sci. 52(2), 940–946 (2011).
[CrossRef] [PubMed]

A. S. Raza, J. Cho, C. G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, and D. C. Hood, “Macular retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma,” Arch. Ophthalmol. (to be published).

De Moraes, C. V.

M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, C. V. De Moraes, X. Zhang, R. Ritch, and J. M. Liebmann, “Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography,” Arch. Ophthalmol. 127(7), 875–881 (2009).
[CrossRef] [PubMed]

Drasdo, N.

N. Drasdo, C. L. Millican, C. R. Katholi, and C. A. Curcio, “The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field,” Vision Res. 47(22), 2901–2911 (2007).
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Fujimoto, J. G.

J. S. Schuman, M. R. Hee, A. V. Arya, T. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. A. Swanson, “Optical coherence tomography: a new tool for glaucoma diagnosis,” Curr. Opin. Ophthalmol. 6(2), 89–95 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Fukuma, Y.

Ghadiali, Q.

M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, C. V. De Moraes, X. Zhang, R. Ritch, and J. M. Liebmann, “Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography,” Arch. Ophthalmol. 127(7), 875–881 (2009).
[CrossRef] [PubMed]

Greenstein, V. C.

D. C. Hood, A. S. Raza, C. G. V. de Moraes, J. G. Odel, V. C. Greenstein, J. M. Liebmann, and R. Ritch, “Initial arcuate defects within the central 10 degrees in glaucoma,” Invest. Ophthalmol. Vis. Sci. 52(2), 940–946 (2011).
[CrossRef] [PubMed]

D. C. Hood and V. C. Greenstein, “Multifocal VEP and ganglion cell damage: applications and limitations for the study of glaucoma,” Prog. Retin. Eye Res. 22(2), 201–251 (2003).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hangai, M.

Hee, M. R.

J. S. Schuman, M. R. Hee, A. V. Arya, T. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. A. Swanson, “Optical coherence tomography: a new tool for glaucoma diagnosis,” Curr. Opin. Ophthalmol. 6(2), 89–95 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hood, D. C.

D. C. Hood, A. S. Raza, C. G. V. de Moraes, J. G. Odel, V. C. Greenstein, J. M. Liebmann, and R. Ritch, “Initial arcuate defects within the central 10 degrees in glaucoma,” Invest. Ophthalmol. Vis. Sci. 52(2), 940–946 (2011).
[CrossRef] [PubMed]

Q. Yang, C. A. Reisman, Z. Wang, Y. Fukuma, M. Hangai, N. Yoshimura, A. Tomidokoro, M. Araie, A. S. Raza, D. C. Hood, and K. Chan, “Automated layer segmentation of macular OCT images using dual-scale gradient information,” Opt. Express 18(20), 21293–21307 (2010).
[CrossRef] [PubMed]

M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, C. V. De Moraes, X. Zhang, R. Ritch, and J. M. Liebmann, “Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography,” Arch. Ophthalmol. 127(7), 875–881 (2009).
[CrossRef] [PubMed]

D. C. Hood and V. C. Greenstein, “Multifocal VEP and ganglion cell damage: applications and limitations for the study of glaucoma,” Prog. Retin. Eye Res. 22(2), 201–251 (2003).
[CrossRef] [PubMed]

A. S. Raza, J. Cho, C. G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, and D. C. Hood, “Macular retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma,” Arch. Ophthalmol. (to be published).

Huang, D.

O. Tan, V. Chopra, A. T. Lu, J. S. Schuman, H. Ishikawa, G. Wollstein, R. Varma, and D. Huang, “Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography,” Ophthalmology 116(12), 2305–2314.e2, (2009).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Ishikawa, H.

O. Tan, V. Chopra, A. T. Lu, J. S. Schuman, H. Ishikawa, G. Wollstein, R. Varma, and D. Huang, “Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography,” Ophthalmology 116(12), 2305–2314.e2, (2009).
[CrossRef] [PubMed]

Kang, S. Y.

J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010).
[CrossRef] [PubMed]

Kardon, R. H.

A. S. Raza, J. Cho, C. G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, and D. C. Hood, “Macular retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma,” Arch. Ophthalmol. (to be published).

Katholi, C. R.

N. Drasdo, C. L. Millican, C. R. Katholi, and C. A. Curcio, “The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field,” Vision Res. 47(22), 2901–2911 (2007).
[CrossRef] [PubMed]

Kim, C. Y.

N. R. Kim, E. S. Lee, G. J. Seong, J. H. Kim, H. G. An, and C. Y. Kim, “Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma,” Invest. Ophthalmol. Vis. Sci. 51(9), 4646–4651 (2010).
[CrossRef] [PubMed]

Kim, J. H.

N. R. Kim, E. S. Lee, G. J. Seong, J. H. Kim, H. G. An, and C. Y. Kim, “Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma,” Invest. Ophthalmol. Vis. Sci. 51(9), 4646–4651 (2010).
[CrossRef] [PubMed]

Kim, N. R.

N. R. Kim, E. S. Lee, G. J. Seong, J. H. Kim, H. G. An, and C. Y. Kim, “Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma,” Invest. Ophthalmol. Vis. Sci. 51(9), 4646–4651 (2010).
[CrossRef] [PubMed]

Kook, M. S.

J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010).
[CrossRef] [PubMed]

Lee, E. S.

N. R. Kim, E. S. Lee, G. J. Seong, J. H. Kim, H. G. An, and C. Y. Kim, “Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma,” Invest. Ophthalmol. Vis. Sci. 51(9), 4646–4651 (2010).
[CrossRef] [PubMed]

Lee, S.

J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010).
[CrossRef] [PubMed]

Lee, Y.

J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010).
[CrossRef] [PubMed]

Liebmann, J. M.

D. C. Hood, A. S. Raza, C. G. V. de Moraes, J. G. Odel, V. C. Greenstein, J. M. Liebmann, and R. Ritch, “Initial arcuate defects within the central 10 degrees in glaucoma,” Invest. Ophthalmol. Vis. Sci. 52(2), 940–946 (2011).
[CrossRef] [PubMed]

M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, C. V. De Moraes, X. Zhang, R. Ritch, and J. M. Liebmann, “Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography,” Arch. Ophthalmol. 127(7), 875–881 (2009).
[CrossRef] [PubMed]

A. S. Raza, J. Cho, C. G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, and D. C. Hood, “Macular retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma,” Arch. Ophthalmol. (to be published).

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Lu, A. T.

O. Tan, V. Chopra, A. T. Lu, J. S. Schuman, H. Ishikawa, G. Wollstein, R. Varma, and D. Huang, “Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography,” Ophthalmology 116(12), 2305–2314.e2, (2009).
[CrossRef] [PubMed]

Millican, C. L.

N. Drasdo, C. L. Millican, C. R. Katholi, and C. A. Curcio, “The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field,” Vision Res. 47(22), 2901–2911 (2007).
[CrossRef] [PubMed]

Na, J. H.

J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010).
[CrossRef] [PubMed]

Odel, J. G.

D. C. Hood, A. S. Raza, C. G. V. de Moraes, J. G. Odel, V. C. Greenstein, J. M. Liebmann, and R. Ritch, “Initial arcuate defects within the central 10 degrees in glaucoma,” Invest. Ophthalmol. Vis. Sci. 52(2), 940–946 (2011).
[CrossRef] [PubMed]

Pedut-Kloizman, T.

J. S. Schuman, M. R. Hee, A. V. Arya, T. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. A. Swanson, “Optical coherence tomography: a new tool for glaucoma diagnosis,” Curr. Opin. Ophthalmol. 6(2), 89–95 (1995).
[PubMed]

Puliafito, C. A.

J. S. Schuman, M. R. Hee, A. V. Arya, T. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. A. Swanson, “Optical coherence tomography: a new tool for glaucoma diagnosis,” Curr. Opin. Ophthalmol. 6(2), 89–95 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Raza, A. S.

D. C. Hood, A. S. Raza, C. G. V. de Moraes, J. G. Odel, V. C. Greenstein, J. M. Liebmann, and R. Ritch, “Initial arcuate defects within the central 10 degrees in glaucoma,” Invest. Ophthalmol. Vis. Sci. 52(2), 940–946 (2011).
[CrossRef] [PubMed]

Q. Yang, C. A. Reisman, Z. Wang, Y. Fukuma, M. Hangai, N. Yoshimura, A. Tomidokoro, M. Araie, A. S. Raza, D. C. Hood, and K. Chan, “Automated layer segmentation of macular OCT images using dual-scale gradient information,” Opt. Express 18(20), 21293–21307 (2010).
[CrossRef] [PubMed]

A. S. Raza, J. Cho, C. G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, and D. C. Hood, “Macular retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma,” Arch. Ophthalmol. (to be published).

Reisman, C. A.

Ritch, R.

D. C. Hood, A. S. Raza, C. G. V. de Moraes, J. G. Odel, V. C. Greenstein, J. M. Liebmann, and R. Ritch, “Initial arcuate defects within the central 10 degrees in glaucoma,” Invest. Ophthalmol. Vis. Sci. 52(2), 940–946 (2011).
[CrossRef] [PubMed]

M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, C. V. De Moraes, X. Zhang, R. Ritch, and J. M. Liebmann, “Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography,” Arch. Ophthalmol. 127(7), 875–881 (2009).
[CrossRef] [PubMed]

A. S. Raza, J. Cho, C. G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, and D. C. Hood, “Macular retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma,” Arch. Ophthalmol. (to be published).

Schuman, J. S.

O. Tan, V. Chopra, A. T. Lu, J. S. Schuman, H. Ishikawa, G. Wollstein, R. Varma, and D. Huang, “Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography,” Ophthalmology 116(12), 2305–2314.e2, (2009).
[CrossRef] [PubMed]

J. S. Schuman, M. R. Hee, A. V. Arya, T. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. A. Swanson, “Optical coherence tomography: a new tool for glaucoma diagnosis,” Curr. Opin. Ophthalmol. 6(2), 89–95 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Seong, G. J.

N. R. Kim, E. S. Lee, G. J. Seong, J. H. Kim, H. G. An, and C. Y. Kim, “Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma,” Invest. Ophthalmol. Vis. Sci. 51(9), 4646–4651 (2010).
[CrossRef] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Sung, K. R.

J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010).
[CrossRef] [PubMed]

Swanson, E. A.

J. S. Schuman, M. R. Hee, A. V. Arya, T. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. A. Swanson, “Optical coherence tomography: a new tool for glaucoma diagnosis,” Curr. Opin. Ophthalmol. 6(2), 89–95 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Tan, O.

O. Tan, V. Chopra, A. T. Lu, J. S. Schuman, H. Ishikawa, G. Wollstein, R. Varma, and D. Huang, “Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography,” Ophthalmology 116(12), 2305–2314.e2, (2009).
[CrossRef] [PubMed]

Tomidokoro, A.

Varma, R.

O. Tan, V. Chopra, A. T. Lu, J. S. Schuman, H. Ishikawa, G. Wollstein, R. Varma, and D. Huang, “Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography,” Ophthalmology 116(12), 2305–2314.e2, (2009).
[CrossRef] [PubMed]

Wang, M.

M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, C. V. De Moraes, X. Zhang, R. Ritch, and J. M. Liebmann, “Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography,” Arch. Ophthalmol. 127(7), 875–881 (2009).
[CrossRef] [PubMed]

A. S. Raza, J. Cho, C. G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, and D. C. Hood, “Macular retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma,” Arch. Ophthalmol. (to be published).

Wang, Z.

Wollstein, G.

O. Tan, V. Chopra, A. T. Lu, J. S. Schuman, H. Ishikawa, G. Wollstein, R. Varma, and D. Huang, “Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography,” Ophthalmology 116(12), 2305–2314.e2, (2009).
[CrossRef] [PubMed]

Yang, Q.

Yoshimura, N.

Yun, S. C.

J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010).
[CrossRef] [PubMed]

Zhang, X.

M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, C. V. De Moraes, X. Zhang, R. Ritch, and J. M. Liebmann, “Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography,” Arch. Ophthalmol. 127(7), 875–881 (2009).
[CrossRef] [PubMed]

A. S. Raza, J. Cho, C. G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, and D. C. Hood, “Macular retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma,” Arch. Ophthalmol. (to be published).

Arch. Ophthalmol. (2)

M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, C. V. De Moraes, X. Zhang, R. Ritch, and J. M. Liebmann, “Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography,” Arch. Ophthalmol. 127(7), 875–881 (2009).
[CrossRef] [PubMed]

A. S. Raza, J. Cho, C. G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, and D. C. Hood, “Macular retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma,” Arch. Ophthalmol. (to be published).

Curr. Opin. Ophthalmol. (1)

J. S. Schuman, M. R. Hee, A. V. Arya, T. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. A. Swanson, “Optical coherence tomography: a new tool for glaucoma diagnosis,” Curr. Opin. Ophthalmol. 6(2), 89–95 (1995).
[PubMed]

Invest. Ophthalmol. Vis. Sci. (3)

N. R. Kim, E. S. Lee, G. J. Seong, J. H. Kim, H. G. An, and C. Y. Kim, “Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma,” Invest. Ophthalmol. Vis. Sci. 51(9), 4646–4651 (2010).
[CrossRef] [PubMed]

J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010).
[CrossRef] [PubMed]

D. C. Hood, A. S. Raza, C. G. V. de Moraes, J. G. Odel, V. C. Greenstein, J. M. Liebmann, and R. Ritch, “Initial arcuate defects within the central 10 degrees in glaucoma,” Invest. Ophthalmol. Vis. Sci. 52(2), 940–946 (2011).
[CrossRef] [PubMed]

Ophthalmology (1)

O. Tan, V. Chopra, A. T. Lu, J. S. Schuman, H. Ishikawa, G. Wollstein, R. Varma, and D. Huang, “Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography,” Ophthalmology 116(12), 2305–2314.e2, (2009).
[CrossRef] [PubMed]

Opt. Express (1)

Prog. Retin. Eye Res. (1)

D. C. Hood and V. C. Greenstein, “Multifocal VEP and ganglion cell damage: applications and limitations for the study of glaucoma,” Prog. Retin. Eye Res. 22(2), 201–251 (2003).
[CrossRef] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Vision Res. (1)

N. Drasdo, C. L. Millican, C. R. Katholi, and C. A. Curcio, “The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field,” Vision Res. 47(22), 2901–2911 (2007).
[CrossRef] [PubMed]

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Figures (7)

Fig. 1
Fig. 1

Sample thickness maps and scans from a healthy control. A. RGC + IPL thickness map (left) and a scan through the horizontal meridian with the segmentation displayed in light blue (right). B. RNFL thickness map (left) and a scan through the horizontal meridian (right). C. RNFL thickness map (left) and a scan through the center of the optic disc (right).

Fig. 2
Fig. 2

RGC + IPL and RNFL thickness maps for the control in Fig. 1A. Combined RNFL thickness maps from scans of the macula and optic disc. B. Same scans as in A shown with iso-thickness contours and after flipping across the horizontal axis to present in field view. C. Same as in B for RGC + IPL thickness.

Fig. 3
Fig. 3

Sample visual fields and OCT thickness maps. A. 24-2 (left panel) and 10-2 (second column) visual fields are shown for a healthy control along with the thickness maps for the macula RGC + IPL (middle panel) and RNFL thickness (fourth panel), and the optic disc RNFL thickness (right panel). B,C,D. Same as in A for 3 patients.

Fig. 4
Fig. 4

RGC + IPL and RNFL maps for patient 1. A. OCT thickness maps as in Figs. 2B, C. B. Maps from panel A with 10-2 test locations displaced based upon displacement of RGCs. C. Probability maps for OCT thickness.

Fig. 5
Fig. 5

A-C. Combined OCT/10-2 probability maps for the 3 patients from Fig. 3.

Fig. 6
Fig. 6

Results for patient 4. A.B. Combined OCT/10-2 probability maps. C. 10-2 Total Deviation map.

Fig. 7
Fig. 7

Results for patient 5. A, B. Combined OCT/10-2 probability maps. C. 10-2 Total Deviation map. D. 10-2 Pattern Deviation map.

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