Abstract

Knowledge of the existence of filaggrin (FLG) gene mutations might be helpful for a subclassification of patients with atopic dermatitis (AD) which can be used to introduce individualized treatments. In this work the filaggrin content in the skin is assessed using Raman spectroscopy and the results are compared to FLG genotyping of Mexican-mestizo patients. Results showed that the 2282del4 and R501X mutations present in the European population but absent in people of Asian or African descent are also present in the Mexican-mestizo population. The results also showed that patients with filaggrin gene mutations presented lower filaggrin concentrations measured using the vector correlation of their skin Raman spectra and a fixed spectrum of pure human recombinant filaggrin, these results indicate that Raman spectroscopy may be used as a noninvasive tool to detect FLG gene mutations.

© 2011 OSA

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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]

2011 (2)

F. J. González, J. Alda, B. Moreno-Cruz, M. Martínez-Escanamé, M. G. Ramírez-Elías, B. Torres-Álvarez, and B. Moncada, “Use of Raman spectroscopy for the early detection of filaggrin-related atopic dermatitis,” Skin Res. Technol.17(1), 45–50 (2011).
[CrossRef] [PubMed]

N. Novak and D. Simon, “Atopic dermatitis - from new pathophysiologic insights to individualized therapy,” Allergy66(7), 830–839 (2011).
[CrossRef] [PubMed]

2010 (1)

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

2008 (1)

S. Kezic, P. M. J. H. Kemperman, E. S. Koster, C. M. de Jongh, H. B. Thio, L. E. Campbell, A. D. Irvine, W. H. McLean, G. J. Puppels, and P. J. Caspers, “Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum,” J. Invest. Dermatol.128(8), 2117–2119 (2008).
[CrossRef] [PubMed]

2007 (1)

2006 (3)

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Alda, J.

F. J. González, J. Alda, B. Moreno-Cruz, M. Martínez-Escanamé, M. G. Ramírez-Elías, B. Torres-Álvarez, and B. Moncada, “Use of Raman spectroscopy for the early detection of filaggrin-related atopic dermatitis,” Skin Res. Technol.17(1), 45–50 (2011).
[CrossRef] [PubMed]

Arseculeratne, G.

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Bale, S. J.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

Bisgaard, H.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Campbell, L. E.

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

S. Kezic, P. M. J. H. Kemperman, E. S. Koster, C. M. de Jongh, H. B. Thio, L. E. Campbell, A. D. Irvine, W. H. McLean, G. J. Puppels, and P. J. Caspers, “Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum,” J. Invest. Dermatol.128(8), 2117–2119 (2008).
[CrossRef] [PubMed]

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Caspers, P. J.

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

S. Kezic, P. M. J. H. Kemperman, E. S. Koster, C. M. de Jongh, H. B. Thio, L. E. Campbell, A. D. Irvine, W. H. McLean, G. J. Puppels, and P. J. Caspers, “Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum,” J. Invest. Dermatol.128(8), 2117–2119 (2008).
[CrossRef] [PubMed]

Cecil, J. E.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Chen, H.

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

Compton, J. G.

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

de Jongh, C. M.

S. Kezic, P. M. J. H. Kemperman, E. S. Koster, C. M. de Jongh, H. B. Thio, L. E. Campbell, A. D. Irvine, W. H. McLean, G. J. Puppels, and P. J. Caspers, “Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum,” J. Invest. Dermatol.128(8), 2117–2119 (2008).
[CrossRef] [PubMed]

DiGiovanna, J. J.

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

El Houate, B.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Esparza-Gordillo, J.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Evans, A. T.

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

Fleckman, P.

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

González, F. J.

F. J. González, J. Alda, B. Moreno-Cruz, M. Martínez-Escanamé, M. G. Ramírez-Elías, B. Torres-Álvarez, and B. Moncada, “Use of Raman spectroscopy for the early detection of filaggrin-related atopic dermatitis,” Skin Res. Technol.17(1), 45–50 (2011).
[CrossRef] [PubMed]

Goudie, D. R.

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Grüber, C.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Halkjaer, L. B.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Irvine, A. D.

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

S. Kezic, P. M. J. H. Kemperman, E. S. Koster, C. M. de Jongh, H. B. Thio, L. E. Campbell, A. D. Irvine, W. H. McLean, G. J. Puppels, and P. J. Caspers, “Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum,” J. Invest. Dermatol.128(8), 2117–2119 (2008).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

Keil, T.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Kemperman, P. M.

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

Kemperman, P. M. J. H.

S. Kezic, P. M. J. H. Kemperman, E. S. Koster, C. M. de Jongh, H. B. Thio, L. E. Campbell, A. D. Irvine, W. H. McLean, G. J. Puppels, and P. J. Caspers, “Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum,” J. Invest. Dermatol.128(8), 2117–2119 (2008).
[CrossRef] [PubMed]

Kerscher, T.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Kezic, S.

S. Kezic, P. M. J. H. Kemperman, E. S. Koster, C. M. de Jongh, H. B. Thio, L. E. Campbell, A. D. Irvine, W. H. McLean, G. J. Puppels, and P. J. Caspers, “Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum,” J. Invest. Dermatol.128(8), 2117–2119 (2008).
[CrossRef] [PubMed]

Koster, E. S.

S. Kezic, P. M. J. H. Kemperman, E. S. Koster, C. M. de Jongh, H. B. Thio, L. E. Campbell, A. D. Irvine, W. H. McLean, G. J. Puppels, and P. J. Caspers, “Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum,” J. Invest. Dermatol.128(8), 2117–2119 (2008).
[CrossRef] [PubMed]

Kroboth, K.

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

Kurek, M.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Lau, S.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Lee, S. P.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Lee, Y.-A.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Lewis-Jones, S.

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Liao, H.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

Lui, H.

Marenholz, I.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Martínez-Escanamé, M.

F. J. González, J. Alda, B. Moreno-Cruz, M. Martínez-Escanamé, M. G. Ramírez-Elías, B. Torres-Álvarez, and B. Moncada, “Use of Raman spectroscopy for the early detection of filaggrin-related atopic dermatitis,” Skin Res. Technol.17(1), 45–50 (2011).
[CrossRef] [PubMed]

McElreavey, K.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

McLean, D. I.

McLean, W. H.

S. Kezic, P. M. J. H. Kemperman, E. S. Koster, C. M. de Jongh, H. B. Thio, L. E. Campbell, A. D. Irvine, W. H. McLean, G. J. Puppels, and P. J. Caspers, “Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum,” J. Invest. Dermatol.128(8), 2117–2119 (2008).
[CrossRef] [PubMed]

McLean, W. H. I.

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Moncada, B.

F. J. González, J. Alda, B. Moreno-Cruz, M. Martínez-Escanamé, M. G. Ramírez-Elías, B. Torres-Álvarez, and B. Moncada, “Use of Raman spectroscopy for the early detection of filaggrin-related atopic dermatitis,” Skin Res. Technol.17(1), 45–50 (2011).
[CrossRef] [PubMed]

Moreno-Cruz, B.

F. J. González, J. Alda, B. Moreno-Cruz, M. Martínez-Escanamé, M. G. Ramírez-Elías, B. Torres-Álvarez, and B. Moncada, “Use of Raman spectroscopy for the early detection of filaggrin-related atopic dermatitis,” Skin Res. Technol.17(1), 45–50 (2011).
[CrossRef] [PubMed]

Mukhopadhyay, S.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Munro, C. S.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

Nickel, R.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Novak, N.

N. Novak and D. Simon, “Atopic dermatitis - from new pathophysiologic insights to individualized therapy,” Allergy66(7), 830–839 (2011).
[CrossRef] [PubMed]

O’Regan, G.

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

O’Regan, G. M.

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Palmer, C. N.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Presland, R. B.

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

Puppels, G. J.

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

S. Kezic, P. M. J. H. Kemperman, E. S. Koster, C. M. de Jongh, H. B. Thio, L. E. Campbell, A. D. Irvine, W. H. McLean, G. J. Puppels, and P. J. Caspers, “Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum,” J. Invest. Dermatol.128(8), 2117–2119 (2008).
[CrossRef] [PubMed]

Ramírez-Elías, M. G.

F. J. González, J. Alda, B. Moreno-Cruz, M. Martínez-Escanamé, M. G. Ramírez-Elías, B. Torres-Álvarez, and B. Moncada, “Use of Raman spectroscopy for the early detection of filaggrin-related atopic dermatitis,” Skin Res. Technol.17(1), 45–50 (2011).
[CrossRef] [PubMed]

Rowland, M.

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

Rüschendorf, F.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Sandilands, A.

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Schulz, F.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Sergeant, A.

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Simon, D.

N. Novak and D. Simon, “Atopic dermatitis - from new pathophysiologic insights to individualized therapy,” Allergy66(7), 830–839 (2011).
[CrossRef] [PubMed]

Smith, F. J. D.

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Terron-Kwiatkowski, A.

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Thio, H. B.

S. Kezic, P. M. J. H. Kemperman, E. S. Koster, C. M. de Jongh, H. B. Thio, L. E. Campbell, A. D. Irvine, W. H. McLean, G. J. Puppels, and P. J. Caspers, “Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum,” J. Invest. Dermatol.128(8), 2117–2119 (2008).
[CrossRef] [PubMed]

Torres-Álvarez, B.

F. J. González, J. Alda, B. Moreno-Cruz, M. Martínez-Escanamé, M. G. Ramírez-Elías, B. Torres-Álvarez, and B. Moncada, “Use of Raman spectroscopy for the early detection of filaggrin-related atopic dermatitis,” Skin Res. Technol.17(1), 45–50 (2011).
[CrossRef] [PubMed]

Wahn, U.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Watson, R.

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

Watson, R. M.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

Worm, M.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Zaluga, E.

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

Zeng, H.

Zhao, J.

Zhao, Y.

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

Allergy (1)

N. Novak and D. Simon, “Atopic dermatitis - from new pathophysiologic insights to individualized therapy,” Allergy66(7), 830–839 (2011).
[CrossRef] [PubMed]

Appl. Spectrosc. (1)

J. Allergy Clin. Immunol. (2)

G. M. O’Regan, P. M. Kemperman, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, G. J. Puppels, W. H. I. McLean, P. J. Caspers, and A. D. Irvine, “Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes,” J. Allergy Clin. Immunol.126(3), 574–580.e1 (2010).
[CrossRef] [PubMed]

I. Marenholz, R. Nickel, F. Rüschendorf, F. Schulz, J. Esparza-Gordillo, T. Kerscher, C. Grüber, S. Lau, M. Worm, T. Keil, M. Kurek, E. Zaluga, U. Wahn, and Y.-A. Lee, “Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march,” J. Allergy Clin. Immunol.118(4), 866–871 (2006).
[CrossRef] [PubMed]

J. Invest. Dermatol. (1)

S. Kezic, P. M. J. H. Kemperman, E. S. Koster, C. M. de Jongh, H. B. Thio, L. E. Campbell, A. D. Irvine, W. H. McLean, G. J. Puppels, and P. J. Caspers, “Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum,” J. Invest. Dermatol.128(8), 2117–2119 (2008).
[CrossRef] [PubMed]

Nat. Genet. (2)

C. N. Palmer, A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, G. M. O’Regan, R. M. Watson, J. E. Cecil, S. J. Bale, J. G. Compton, J. J. DiGiovanna, P. Fleckman, S. Lewis-Jones, G. Arseculeratne, A. Sergeant, C. S. Munro, B. El Houate, K. McElreavey, L. B. Halkjaer, H. Bisgaard, S. Mukhopadhyay, and W. H. I. McLean, “Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis,” Nat. Genet.38(4), 441–446 (2006).
[CrossRef] [PubMed]

F. J. D. Smith, A. D. Irvine, A. Terron-Kwiatkowski, A. Sandilands, L. E. Campbell, Y. Zhao, H. Liao, A. T. Evans, D. R. Goudie, S. Lewis-Jones, G. Arseculeratne, C. S. Munro, A. Sergeant, G. O’Regan, S. J. Bale, J. G. Compton, J. J. DiGiovanna, R. B. Presland, P. Fleckman, and W. H. I. McLean, “Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris,” Nat. Genet.38(3), 337–342 (2006).
[CrossRef] [PubMed]

Skin Res. Technol. (1)

F. J. González, J. Alda, B. Moreno-Cruz, M. Martínez-Escanamé, M. G. Ramírez-Elías, B. Torres-Álvarez, and B. Moncada, “Use of Raman spectroscopy for the early detection of filaggrin-related atopic dermatitis,” Skin Res. Technol.17(1), 45–50 (2011).
[CrossRef] [PubMed]

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Figures (3)

Fig. 1
Fig. 1

(a) Raw Raman spectrum of skin, (b) Raman spectrum of skin with the background fluorescence signal subtracted.

Fig. 2
Fig. 2

Raman spectrum of pure human recombinant filaggrin.

Fig. 3
Fig. 3

Vector correlation of the Raman spectrum of pure human filaggrin with the Raman spectra of the skin of patients with pruritus and dry skin, the FLG + points show the patients without a FLG mutation, while the FLG – points represent patients with a FLG mutation.

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