Abstract

Intravascular photoacoustics (IVPA)—a minimally invasive imaging technique with contrast related to optical absorption properties of tissue, can be used to visualize atherosclerotic plaques. However, the amplitude of photoacoustic signals is also related to a temperature dependent, tissue specific parameter—the Grüneisen parameter. Therefore, photoacoustic signals measured at different temperatures may reveal information about tissue composition. In this study, thermal IVPA (tIVPA) imaging was introduced. The imaging studies were performed using an ex vivo atherosclerotic rabbit aorta. Temperature dependent photoacoustic responses from lipid in plaques and lipid in periadventitial tissue were different, thus allowing tIVPA images to delineate the location of lipid-rich plaques. The results indicate that tIVPA imaging has a potential to characterize tissue composition in atherosclerotic vessels.

© 2011 OSA

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    [PubMed]

2011 (2)

T. Kobayashi, T. Ito, and M. Shiomi, “Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseases,” J. Biomed. Biotechnol.2011, 406473 (2011).
[CrossRef] [PubMed]

K. Jansen, A. F. W. van der Steen, H. M. M. van Beusekom, J. W. Oosterhuis, and G. van Soest, “Intravascular photoacoustic imaging of human coronary atherosclerosis,” Opt. Lett.36(5), 597–599 (2011).
[CrossRef] [PubMed]

2010 (1)

2009 (3)

T. J. Allen and P. C. Beard, “Photoacoustic characterisation of vascular tissue at NIR wavelengths,” Proc. SPIE7177, 71770A, 71770A-9 (2009).
[CrossRef]

M. Shiomi and T. Ito, “The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: a tribute to the late Dr. Yoshio Watanabe,” Atherosclerosis207(1), 1–7 (2009).
[CrossRef] [PubMed]

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett.9(6), 2212–2217 (2009).
[CrossRef] [PubMed]

2008 (2)

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt.13(3), 034024 (2008).
[CrossRef] [PubMed]

S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express16(5), 3362–3367 (2008).
[CrossRef] [PubMed]

2007 (2)

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med.131(3), 481–487 (2007).
[PubMed]

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(5), 978–986 (2007).
[CrossRef] [PubMed]

2006 (1)

E. Falk, “Pathogenesis of atherosclerosis,” J. Am. Coll. Cardiol.47(8Suppl), C7–C12 (2006).
[CrossRef] [PubMed]

2005 (2)

Y. Shi, R. S. Witte, and M. O’Donnell, “Identification of vulnerable atherosclerotic plaque using IVUS-based thermal strain imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control52(5), 844–850 (2005).
[CrossRef] [PubMed]

I. V. Larina, K. V. Larin, and R. O. Esenaliev, “Real-time optoacoustic monitoring of temperature in tissues,” J. Phys. D Appl. Phys.38(15), 2633–2639 (2005).
[CrossRef]

2004 (1)

D. Steinberg, “Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part I,” J. Lipid Res.45(9), 1583–1593 (2004).
[CrossRef] [PubMed]

2002 (3)

R. Virmani, A. P. Burke, A. Farb, and F. D. Kolodgie, “Pathology of the unstable plaque,” Prog. Cardiovasc. Dis.44(5), 349–356 (2002).
[CrossRef] [PubMed]

C. L. de Korte, M. J. Sierevogel, F. Mastik, C. Strijder, J. A. Schaar, E. Velema, G. Pasterkamp, P. W. Serruys, and A. F. W. van der Steen, “Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study,” Circulation105(14), 1627–1630 (2002).
[CrossRef] [PubMed]

A. Nair, B. D. Kuban, E. M. Tuzcu, P. Schoenhagen, S. E. Nissen, and D. G. Vince, “Coronary plaque classification with intravascular ultrasound radiofrequency data analysis,” Circulation106(17), 2200–2206 (2002).
[CrossRef] [PubMed]

2001 (2)

S. E. Nissen and P. Yock, “Intravascular ultrasound: novel pathophysiological insights and current clinical applications,” Circulation103(4), 604–616 (2001).
[PubMed]

C. L. Tsai, J. C. Chen, and W. J. Wang, “Near-infrared absorption property of biological soft tissue constituents,” J. Med. Biol. Eng.21, 7–14 (2001).

1999 (1)

J. M. Sun and B. S. Gerstman, “Photoacoustic generation for a spherical absorber with impedance mismatch with the surrounding media,” Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics59(5 Pt B), 5772–5789 (1999).
[CrossRef] [PubMed]

1997 (1)

P. C. Beard and T. N. Mills, “Characterization of post mortem arterial tissue using time-resolved photoacoustic spectroscopy at 436, 461 and 532 nm,” Phys. Med. Biol.42(1), 177–198 (1997).
[CrossRef] [PubMed]

1993 (1)

Q. X. Chen, A. Davies, R. J. Dewhurst, and P. A. Payne, “Photo-acoustic probe for intra-arterial imaging and therapy,” Electron. Lett.29(18), 1632–1633 (1993).
[CrossRef]

1982 (1)

R. J. Havel, T. Kita, L. Kotite, J. P. Kane, R. L. Hamilton, J. L. Goldstein, and M. S. Brown, “Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia,” Arteriosclerosis2(6), 467–474 (1982).
[CrossRef] [PubMed]

Aglyamov, S.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt.13(3), 034024 (2008).
[CrossRef] [PubMed]

Aglyamov, S. R.

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(5), 978–986 (2007).
[CrossRef] [PubMed]

Allen, T. J.

T. J. Allen and P. C. Beard, “Photoacoustic characterisation of vascular tissue at NIR wavelengths,” Proc. SPIE7177, 71770A, 71770A-9 (2009).
[CrossRef]

Amirian, J.

Amirian, J. H.

S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express16(5), 3362–3367 (2008).
[CrossRef] [PubMed]

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(5), 978–986 (2007).
[CrossRef] [PubMed]

Beard, P. C.

T. J. Allen and P. C. Beard, “Photoacoustic characterisation of vascular tissue at NIR wavelengths,” Proc. SPIE7177, 71770A, 71770A-9 (2009).
[CrossRef]

P. C. Beard and T. N. Mills, “Characterization of post mortem arterial tissue using time-resolved photoacoustic spectroscopy at 436, 461 and 532 nm,” Phys. Med. Biol.42(1), 177–198 (1997).
[CrossRef] [PubMed]

Brown, M. S.

R. J. Havel, T. Kita, L. Kotite, J. P. Kane, R. L. Hamilton, J. L. Goldstein, and M. S. Brown, “Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia,” Arteriosclerosis2(6), 467–474 (1982).
[CrossRef] [PubMed]

Buja, L. M.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med.131(3), 481–487 (2007).
[PubMed]

Burke, A.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med.131(3), 481–487 (2007).
[PubMed]

Burke, A. P.

R. Virmani, A. P. Burke, A. Farb, and F. D. Kolodgie, “Pathology of the unstable plaque,” Prog. Cardiovasc. Dis.44(5), 349–356 (2002).
[CrossRef] [PubMed]

Casscells, S. W.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med.131(3), 481–487 (2007).
[PubMed]

Chen, J. C.

C. L. Tsai, J. C. Chen, and W. J. Wang, “Near-infrared absorption property of biological soft tissue constituents,” J. Med. Biol. Eng.21, 7–14 (2001).

Chen, Q. X.

Q. X. Chen, A. Davies, R. J. Dewhurst, and P. A. Payne, “Photo-acoustic probe for intra-arterial imaging and therapy,” Electron. Lett.29(18), 1632–1633 (1993).
[CrossRef]

Davies, A.

Q. X. Chen, A. Davies, R. J. Dewhurst, and P. A. Payne, “Photo-acoustic probe for intra-arterial imaging and therapy,” Electron. Lett.29(18), 1632–1633 (1993).
[CrossRef]

de Korte, C. L.

C. L. de Korte, M. J. Sierevogel, F. Mastik, C. Strijder, J. A. Schaar, E. Velema, G. Pasterkamp, P. W. Serruys, and A. F. W. van der Steen, “Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study,” Circulation105(14), 1627–1630 (2002).
[CrossRef] [PubMed]

Dewhurst, R. J.

Q. X. Chen, A. Davies, R. J. Dewhurst, and P. A. Payne, “Photo-acoustic probe for intra-arterial imaging and therapy,” Electron. Lett.29(18), 1632–1633 (1993).
[CrossRef]

Emelianov, S.

Emelianov, S. Y.

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett.9(6), 2212–2217 (2009).
[CrossRef] [PubMed]

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt.13(3), 034024 (2008).
[CrossRef] [PubMed]

S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express16(5), 3362–3367 (2008).
[CrossRef] [PubMed]

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(5), 978–986 (2007).
[CrossRef] [PubMed]

Esenaliev, R. O.

I. V. Larina, K. V. Larin, and R. O. Esenaliev, “Real-time optoacoustic monitoring of temperature in tissues,” J. Phys. D Appl. Phys.38(15), 2633–2639 (2005).
[CrossRef]

Falk, E.

E. Falk, “Pathogenesis of atherosclerosis,” J. Am. Coll. Cardiol.47(8Suppl), C7–C12 (2006).
[CrossRef] [PubMed]

Farb, A.

R. Virmani, A. P. Burke, A. Farb, and F. D. Kolodgie, “Pathology of the unstable plaque,” Prog. Cardiovasc. Dis.44(5), 349–356 (2002).
[CrossRef] [PubMed]

Gerstman, B. S.

J. M. Sun and B. S. Gerstman, “Photoacoustic generation for a spherical absorber with impedance mismatch with the surrounding media,” Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics59(5 Pt B), 5772–5789 (1999).
[CrossRef] [PubMed]

Goldstein, J. L.

R. J. Havel, T. Kita, L. Kotite, J. P. Kane, R. L. Hamilton, J. L. Goldstein, and M. S. Brown, “Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia,” Arteriosclerosis2(6), 467–474 (1982).
[CrossRef] [PubMed]

Hamilton, R. L.

R. J. Havel, T. Kita, L. Kotite, J. P. Kane, R. L. Hamilton, J. L. Goldstein, and M. S. Brown, “Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia,” Arteriosclerosis2(6), 467–474 (1982).
[CrossRef] [PubMed]

Havel, R. J.

R. J. Havel, T. Kita, L. Kotite, J. P. Kane, R. L. Hamilton, J. L. Goldstein, and M. S. Brown, “Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia,” Arteriosclerosis2(6), 467–474 (1982).
[CrossRef] [PubMed]

Ito, T.

T. Kobayashi, T. Ito, and M. Shiomi, “Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseases,” J. Biomed. Biotechnol.2011, 406473 (2011).
[CrossRef] [PubMed]

M. Shiomi and T. Ito, “The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: a tribute to the late Dr. Yoshio Watanabe,” Atherosclerosis207(1), 1–7 (2009).
[CrossRef] [PubMed]

Jansen, K.

Johnston, K.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt.13(3), 034024 (2008).
[CrossRef] [PubMed]

Kane, J. P.

R. J. Havel, T. Kita, L. Kotite, J. P. Kane, R. L. Hamilton, J. L. Goldstein, and M. S. Brown, “Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia,” Arteriosclerosis2(6), 467–474 (1982).
[CrossRef] [PubMed]

Karpiouk, A. B.

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett.9(6), 2212–2217 (2009).
[CrossRef] [PubMed]

Kita, T.

R. J. Havel, T. Kita, L. Kotite, J. P. Kane, R. L. Hamilton, J. L. Goldstein, and M. S. Brown, “Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia,” Arteriosclerosis2(6), 467–474 (1982).
[CrossRef] [PubMed]

Kobayashi, T.

T. Kobayashi, T. Ito, and M. Shiomi, “Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseases,” J. Biomed. Biotechnol.2011, 406473 (2011).
[CrossRef] [PubMed]

Kolodgie, F. D.

R. Virmani, A. P. Burke, A. Farb, and F. D. Kolodgie, “Pathology of the unstable plaque,” Prog. Cardiovasc. Dis.44(5), 349–356 (2002).
[CrossRef] [PubMed]

Kotite, L.

R. J. Havel, T. Kita, L. Kotite, J. P. Kane, R. L. Hamilton, J. L. Goldstein, and M. S. Brown, “Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia,” Arteriosclerosis2(6), 467–474 (1982).
[CrossRef] [PubMed]

Kuban, B. D.

A. Nair, B. D. Kuban, E. M. Tuzcu, P. Schoenhagen, S. E. Nissen, and D. G. Vince, “Coronary plaque classification with intravascular ultrasound radiofrequency data analysis,” Circulation106(17), 2200–2206 (2002).
[CrossRef] [PubMed]

Larin, K. V.

I. V. Larina, K. V. Larin, and R. O. Esenaliev, “Real-time optoacoustic monitoring of temperature in tissues,” J. Phys. D Appl. Phys.38(15), 2633–2639 (2005).
[CrossRef]

Larina, I. V.

I. V. Larina, K. V. Larin, and R. O. Esenaliev, “Real-time optoacoustic monitoring of temperature in tissues,” J. Phys. D Appl. Phys.38(15), 2633–2639 (2005).
[CrossRef]

Larson, T.

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett.9(6), 2212–2217 (2009).
[CrossRef] [PubMed]

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt.13(3), 034024 (2008).
[CrossRef] [PubMed]

Litovsky, S.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med.131(3), 481–487 (2007).
[PubMed]

Litovsky, S. H.

Ma, L.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt.13(3), 034024 (2008).
[CrossRef] [PubMed]

Madjid, M.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med.131(3), 481–487 (2007).
[PubMed]

Mastik, F.

C. L. de Korte, M. J. Sierevogel, F. Mastik, C. Strijder, J. A. Schaar, E. Velema, G. Pasterkamp, P. W. Serruys, and A. F. W. van der Steen, “Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study,” Circulation105(14), 1627–1630 (2002).
[CrossRef] [PubMed]

Mills, T. N.

P. C. Beard and T. N. Mills, “Characterization of post mortem arterial tissue using time-resolved photoacoustic spectroscopy at 436, 461 and 532 nm,” Phys. Med. Biol.42(1), 177–198 (1997).
[CrossRef] [PubMed]

Milner, T.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt.13(3), 034024 (2008).
[CrossRef] [PubMed]

Naghavi, M.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med.131(3), 481–487 (2007).
[PubMed]

Nair, A.

A. Nair, B. D. Kuban, E. M. Tuzcu, P. Schoenhagen, S. E. Nissen, and D. G. Vince, “Coronary plaque classification with intravascular ultrasound radiofrequency data analysis,” Circulation106(17), 2200–2206 (2002).
[CrossRef] [PubMed]

Nissen, S. E.

A. Nair, B. D. Kuban, E. M. Tuzcu, P. Schoenhagen, S. E. Nissen, and D. G. Vince, “Coronary plaque classification with intravascular ultrasound radiofrequency data analysis,” Circulation106(17), 2200–2206 (2002).
[CrossRef] [PubMed]

S. E. Nissen and P. Yock, “Intravascular ultrasound: novel pathophysiological insights and current clinical applications,” Circulation103(4), 604–616 (2001).
[PubMed]

O’Donnell, M.

Y. Shi, R. S. Witte, and M. O’Donnell, “Identification of vulnerable atherosclerotic plaque using IVUS-based thermal strain imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control52(5), 844–850 (2005).
[CrossRef] [PubMed]

Oosterhuis, J. W.

Park, S.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt.13(3), 034024 (2008).
[CrossRef] [PubMed]

Pasterkamp, G.

C. L. de Korte, M. J. Sierevogel, F. Mastik, C. Strijder, J. A. Schaar, E. Velema, G. Pasterkamp, P. W. Serruys, and A. F. W. van der Steen, “Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study,” Circulation105(14), 1627–1630 (2002).
[CrossRef] [PubMed]

Payne, P. A.

Q. X. Chen, A. Davies, R. J. Dewhurst, and P. A. Payne, “Photo-acoustic probe for intra-arterial imaging and therapy,” Electron. Lett.29(18), 1632–1633 (1993).
[CrossRef]

Schaar, J. A.

C. L. de Korte, M. J. Sierevogel, F. Mastik, C. Strijder, J. A. Schaar, E. Velema, G. Pasterkamp, P. W. Serruys, and A. F. W. van der Steen, “Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study,” Circulation105(14), 1627–1630 (2002).
[CrossRef] [PubMed]

Schoenhagen, P.

A. Nair, B. D. Kuban, E. M. Tuzcu, P. Schoenhagen, S. E. Nissen, and D. G. Vince, “Coronary plaque classification with intravascular ultrasound radiofrequency data analysis,” Circulation106(17), 2200–2206 (2002).
[CrossRef] [PubMed]

Serruys, P. W.

C. L. de Korte, M. J. Sierevogel, F. Mastik, C. Strijder, J. A. Schaar, E. Velema, G. Pasterkamp, P. W. Serruys, and A. F. W. van der Steen, “Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study,” Circulation105(14), 1627–1630 (2002).
[CrossRef] [PubMed]

Sethuraman, S.

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett.9(6), 2212–2217 (2009).
[CrossRef] [PubMed]

S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express16(5), 3362–3367 (2008).
[CrossRef] [PubMed]

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(5), 978–986 (2007).
[CrossRef] [PubMed]

Shah, J.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt.13(3), 034024 (2008).
[CrossRef] [PubMed]

Shi, Y.

Y. Shi, R. S. Witte, and M. O’Donnell, “Identification of vulnerable atherosclerotic plaque using IVUS-based thermal strain imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control52(5), 844–850 (2005).
[CrossRef] [PubMed]

Shiomi, M.

T. Kobayashi, T. Ito, and M. Shiomi, “Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseases,” J. Biomed. Biotechnol.2011, 406473 (2011).
[CrossRef] [PubMed]

M. Shiomi and T. Ito, “The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: a tribute to the late Dr. Yoshio Watanabe,” Atherosclerosis207(1), 1–7 (2009).
[CrossRef] [PubMed]

Sierevogel, M. J.

C. L. de Korte, M. J. Sierevogel, F. Mastik, C. Strijder, J. A. Schaar, E. Velema, G. Pasterkamp, P. W. Serruys, and A. F. W. van der Steen, “Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study,” Circulation105(14), 1627–1630 (2002).
[CrossRef] [PubMed]

Smalling, R.

Smalling, R. W.

S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express16(5), 3362–3367 (2008).
[CrossRef] [PubMed]

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(5), 978–986 (2007).
[CrossRef] [PubMed]

Sokolov, K.

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett.9(6), 2212–2217 (2009).
[CrossRef] [PubMed]

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt.13(3), 034024 (2008).
[CrossRef] [PubMed]

Steinberg, D.

D. Steinberg, “Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part I,” J. Lipid Res.45(9), 1583–1593 (2004).
[CrossRef] [PubMed]

Strijder, C.

C. L. de Korte, M. J. Sierevogel, F. Mastik, C. Strijder, J. A. Schaar, E. Velema, G. Pasterkamp, P. W. Serruys, and A. F. W. van der Steen, “Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study,” Circulation105(14), 1627–1630 (2002).
[CrossRef] [PubMed]

Su, J. L.

B. Wang, J. L. Su, J. Amirian, S. H. Litovsky, R. Smalling, and S. Emelianov, “Detection of lipid in atherosclerotic vessels using ultrasound-guided spectroscopic intravascular photoacoustic imaging,” Opt. Express18(5), 4889–4897 (2010).
[CrossRef] [PubMed]

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett.9(6), 2212–2217 (2009).
[CrossRef] [PubMed]

Sun, J. M.

J. M. Sun and B. S. Gerstman, “Photoacoustic generation for a spherical absorber with impedance mismatch with the surrounding media,” Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics59(5 Pt B), 5772–5789 (1999).
[CrossRef] [PubMed]

Tsai, C. L.

C. L. Tsai, J. C. Chen, and W. J. Wang, “Near-infrared absorption property of biological soft tissue constituents,” J. Med. Biol. Eng.21, 7–14 (2001).

Tuzcu, E. M.

A. Nair, B. D. Kuban, E. M. Tuzcu, P. Schoenhagen, S. E. Nissen, and D. G. Vince, “Coronary plaque classification with intravascular ultrasound radiofrequency data analysis,” Circulation106(17), 2200–2206 (2002).
[CrossRef] [PubMed]

van Beusekom, H. M. M.

van der Steen, A. F. W.

K. Jansen, A. F. W. van der Steen, H. M. M. van Beusekom, J. W. Oosterhuis, and G. van Soest, “Intravascular photoacoustic imaging of human coronary atherosclerosis,” Opt. Lett.36(5), 597–599 (2011).
[CrossRef] [PubMed]

C. L. de Korte, M. J. Sierevogel, F. Mastik, C. Strijder, J. A. Schaar, E. Velema, G. Pasterkamp, P. W. Serruys, and A. F. W. van der Steen, “Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study,” Circulation105(14), 1627–1630 (2002).
[CrossRef] [PubMed]

van Soest, G.

Vela, D.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med.131(3), 481–487 (2007).
[PubMed]

Velema, E.

C. L. de Korte, M. J. Sierevogel, F. Mastik, C. Strijder, J. A. Schaar, E. Velema, G. Pasterkamp, P. W. Serruys, and A. F. W. van der Steen, “Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study,” Circulation105(14), 1627–1630 (2002).
[CrossRef] [PubMed]

Vince, D. G.

A. Nair, B. D. Kuban, E. M. Tuzcu, P. Schoenhagen, S. E. Nissen, and D. G. Vince, “Coronary plaque classification with intravascular ultrasound radiofrequency data analysis,” Circulation106(17), 2200–2206 (2002).
[CrossRef] [PubMed]

Virmani, R.

R. Virmani, A. P. Burke, A. Farb, and F. D. Kolodgie, “Pathology of the unstable plaque,” Prog. Cardiovasc. Dis.44(5), 349–356 (2002).
[CrossRef] [PubMed]

Wang, B.

B. Wang, J. L. Su, J. Amirian, S. H. Litovsky, R. Smalling, and S. Emelianov, “Detection of lipid in atherosclerotic vessels using ultrasound-guided spectroscopic intravascular photoacoustic imaging,” Opt. Express18(5), 4889–4897 (2010).
[CrossRef] [PubMed]

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett.9(6), 2212–2217 (2009).
[CrossRef] [PubMed]

Wang, W. J.

C. L. Tsai, J. C. Chen, and W. J. Wang, “Near-infrared absorption property of biological soft tissue constituents,” J. Med. Biol. Eng.21, 7–14 (2001).

Willerson, J. T.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med.131(3), 481–487 (2007).
[PubMed]

Witte, R. S.

Y. Shi, R. S. Witte, and M. O’Donnell, “Identification of vulnerable atherosclerotic plaque using IVUS-based thermal strain imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control52(5), 844–850 (2005).
[CrossRef] [PubMed]

Yantsen, E.

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett.9(6), 2212–2217 (2009).
[CrossRef] [PubMed]

Yock, P.

S. E. Nissen and P. Yock, “Intravascular ultrasound: novel pathophysiological insights and current clinical applications,” Circulation103(4), 604–616 (2001).
[PubMed]

Arch. Pathol. Lab. Med. (1)

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med.131(3), 481–487 (2007).
[PubMed]

Arteriosclerosis (1)

R. J. Havel, T. Kita, L. Kotite, J. P. Kane, R. L. Hamilton, J. L. Goldstein, and M. S. Brown, “Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia,” Arteriosclerosis2(6), 467–474 (1982).
[CrossRef] [PubMed]

Atherosclerosis (1)

M. Shiomi and T. Ito, “The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: a tribute to the late Dr. Yoshio Watanabe,” Atherosclerosis207(1), 1–7 (2009).
[CrossRef] [PubMed]

Circulation (3)

S. E. Nissen and P. Yock, “Intravascular ultrasound: novel pathophysiological insights and current clinical applications,” Circulation103(4), 604–616 (2001).
[PubMed]

C. L. de Korte, M. J. Sierevogel, F. Mastik, C. Strijder, J. A. Schaar, E. Velema, G. Pasterkamp, P. W. Serruys, and A. F. W. van der Steen, “Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study,” Circulation105(14), 1627–1630 (2002).
[CrossRef] [PubMed]

A. Nair, B. D. Kuban, E. M. Tuzcu, P. Schoenhagen, S. E. Nissen, and D. G. Vince, “Coronary plaque classification with intravascular ultrasound radiofrequency data analysis,” Circulation106(17), 2200–2206 (2002).
[CrossRef] [PubMed]

Electron. Lett. (1)

Q. X. Chen, A. Davies, R. J. Dewhurst, and P. A. Payne, “Photo-acoustic probe for intra-arterial imaging and therapy,” Electron. Lett.29(18), 1632–1633 (1993).
[CrossRef]

IEEE Trans. Ultrason. Ferroelectr. Freq. Control (2)

Y. Shi, R. S. Witte, and M. O’Donnell, “Identification of vulnerable atherosclerotic plaque using IVUS-based thermal strain imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control52(5), 844–850 (2005).
[CrossRef] [PubMed]

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(5), 978–986 (2007).
[CrossRef] [PubMed]

J. Am. Coll. Cardiol. (1)

E. Falk, “Pathogenesis of atherosclerosis,” J. Am. Coll. Cardiol.47(8Suppl), C7–C12 (2006).
[CrossRef] [PubMed]

J. Biomed. Biotechnol. (1)

T. Kobayashi, T. Ito, and M. Shiomi, “Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseases,” J. Biomed. Biotechnol.2011, 406473 (2011).
[CrossRef] [PubMed]

J. Biomed. Opt. (1)

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt.13(3), 034024 (2008).
[CrossRef] [PubMed]

J. Lipid Res. (1)

D. Steinberg, “Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part I,” J. Lipid Res.45(9), 1583–1593 (2004).
[CrossRef] [PubMed]

J. Med. Biol. Eng. (1)

C. L. Tsai, J. C. Chen, and W. J. Wang, “Near-infrared absorption property of biological soft tissue constituents,” J. Med. Biol. Eng.21, 7–14 (2001).

J. Phys. D Appl. Phys. (1)

I. V. Larina, K. V. Larin, and R. O. Esenaliev, “Real-time optoacoustic monitoring of temperature in tissues,” J. Phys. D Appl. Phys.38(15), 2633–2639 (2005).
[CrossRef]

Nano Lett. (1)

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett.9(6), 2212–2217 (2009).
[CrossRef] [PubMed]

Opt. Express (2)

Opt. Lett. (1)

Phys. Med. Biol. (1)

P. C. Beard and T. N. Mills, “Characterization of post mortem arterial tissue using time-resolved photoacoustic spectroscopy at 436, 461 and 532 nm,” Phys. Med. Biol.42(1), 177–198 (1997).
[CrossRef] [PubMed]

Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics (1)

J. M. Sun and B. S. Gerstman, “Photoacoustic generation for a spherical absorber with impedance mismatch with the surrounding media,” Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip. Topics59(5 Pt B), 5772–5789 (1999).
[CrossRef] [PubMed]

Proc. SPIE (1)

T. J. Allen and P. C. Beard, “Photoacoustic characterisation of vascular tissue at NIR wavelengths,” Proc. SPIE7177, 71770A, 71770A-9 (2009).
[CrossRef]

Prog. Cardiovasc. Dis. (1)

R. Virmani, A. P. Burke, A. Farb, and F. D. Kolodgie, “Pathology of the unstable plaque,” Prog. Cardiovasc. Dis.44(5), 349–356 (2002).
[CrossRef] [PubMed]

Other (1)

D. E. Vance and J. E. Vance, Biochemistry of Lipids, Lipoproteins, and Membranes, New Comprehensive Biochemistry (Elsevier, 1996).

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Figures (4)

Fig. 1
Fig. 1

Combined IVUS/IVPA imaging system for tIVPA imaging.

Fig. 2
Fig. 2

(a) IVUS and (b) combined IVUS/IVPA (1210 nm wavelength) images of the atherosclerotic vessel. The images were acquired at 25°C. Yellow arrows in these images indicate the location of atherosclerotic plaques. (c) Oil red O stain confirmed that the imaged aorta had lipid-rich plaques. The angular position of the histological slide was chosen based on the visual correlation of the shape of the vessel wall in histology and the IVUS image. (d) Comparison of the temperature dependent normalized amplitude of PA signal in plaque and the adventitia (error bars correspond to plus/minus one standard deviation).

Fig. 3
Fig. 3

(a) Thermal IVPA (tIVPA) and (b) spectroscopic IVPA (sIVPA) images of the same cross-section of the atherosclerotic artery. Lipid-rich atherosclerotic plaques have similar appearance in tIVPA and sIVPA images while periadventitial fat does not appear in the tIVPA image.

Fig. 4
Fig. 4

Temperature dependence of the normalized amplitude of PA signal measured in a sample of rabbit’s abdominal fat.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

p 0 = v s 2 β C p μ a F e μ eff z ,
Γ= v s 2 β C p ,
D i,j = S i,j T 2 S i,j T 1 ( T 1 T 2 ) S i,j T 1 ,

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