Abstract

Adaptive Optics (AO) is required to achieve diffraction limited resolution in many real-life imaging applications in biology and medicine. AO is essential to guarantee high fidelity visualization of cellular structures for retinal imaging by correcting ocular aberrations. Aberration correction for mouse retinal imaging by direct wavefront measurement has been demonstrated with great success. However, for mouse eyes, the performance of the wavefront sensor (WFS) based AO can be limited by several factors including non-common path errors, wavefront reconstruction errors, and an ill-defined reference plane. Image-based AO can avoid these issues at the cost of algorithmic execution time. Furthermore, image-based approaches can provide improvements to compactness, accessibility, and even the performance of AO systems. Here, we demonstrate the ability of image-based AO to provide comparable aberration correction and image resolution to the conventional Shack-Hartmann WFS-based AO approach. The residual wavefront error of the mouse eye was monitored during a wavefront sensorless optimization to allow comparison with classical AO. This also allowed us to improve the performance of our AO system for small animal retinal imaging.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Full Article  |  PDF Article
OSA Recommended Articles
Wavefront sensorless adaptive optics fluorescence biomicroscope for in vivo retinal imaging in mice

Daniel J. Wahl, Yifan Jian, Stefano Bonora, Robert J. Zawadzki, and Marinko V. Sarunic
Biomed. Opt. Express 7(1) 1-12 (2016)

Sensorless adaptive optics multimodal en-face small animal retinal imaging

Daniel J. Wahl, Ringo Ng, Myeong Jin Ju, Yifan Jian, and Marinko V. Sarunic
Biomed. Opt. Express 10(1) 252-267 (2019)

Adaptive optics retinal imaging in the living mouse eye

Ying Geng, Alfredo Dubra, Lu Yin, William H. Merigan, Robin Sharma, Richard T. Libby, and David R. Williams
Biomed. Opt. Express 3(4) 715-734 (2012)

References

  • View by:
  • |
  • |
  • |

  1. Y. Geng, A. Dubra, L. Yin, W. H. Merigan, R. Sharma, R. T. Libby, and D. R. Williams, “Adaptive optics retinal imaging in the living mouse eye,” Biomed. Opt. Express 3(4), 715–734 (2012).
    [Crossref] [PubMed]
  2. L. Yin, Y. Geng, F. Osakada, R. Sharma, A. H. Cetin, E. M. Callaway, D. R. Williams, and W. H. Merigan, “Imaging light responses of retinal ganglion cells in the living mouse eye,” J. Neurophysiol. 109(9), 2415–2421 (2013).
    [Crossref] [PubMed]
  3. R. Sharma, L. Yin, Y. Geng, W. H. Merigan, G. Palczewska, K. Palczewski, D. R. Williams, and J. J. Hunter, “In vivo two-photon imaging of the mouse retina,” Biomed. Opt. Express 4(8), 1285–1293 (2013).
    [Crossref] [PubMed]
  4. S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
    [Crossref] [PubMed]
  5. X. Zhou, P. Bedggood, and A. Metha, “Limitations to adaptive optics image quality in rodent eyes,” Biomed. Opt. Express 3(8), 1811–1824 (2012).
    [Crossref] [PubMed]
  6. K. Wang, W. Sun, C. T. Richie, B. K. Harvey, E. Betzig, and N. Ji, “Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue,” Nat. Commun. 6(1), 7276 (2015).
    [Crossref] [PubMed]
  7. Y. Geng, L. A. Schery, R. Sharma, A. Dubra, K. Ahmad, R. T. Libby, and D. R. Williams, “Optical properties of the mouse eye,” Biomed. Opt. Express 2(4), 717–738 (2011).
    [Crossref] [PubMed]
  8. J. Schallek, Y. Geng, H. Nguyen, and D. R. Williams, “Morphology and topography of retinal pericytes in the living mouse retina using in vivo adaptive optics imaging and ex vivo characterization,” Invest. Ophthalmol. Vis. Sci. 54(13), 8237–8250 (2013).
    [Crossref] [PubMed]
  9. R. J. Zawadzki, P. Zhang, A. Zam, E. B. Miller, M. Goswami, X. Wang, R. S. Jonnal, S. H. Lee, D. Y. Kim, J. G. Flannery, J. S. Werner, M. E. Burns, and E. N. Pugh, “Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina,” Biomed. Opt. Express 6(6), 2191–2210 (2015).
    [Crossref] [PubMed]
  10. M. J. Booth, “Adaptive optical microscopy: the ongoing quest for a perfect image,” Light Sci. Appl. 3(4), 165 (2014).
    [Crossref]
  11. N. Ji, D. E. Milkie, and E. Betzig, “Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues,” Nat. Methods 7(2), 141–147 (2010).
    [Crossref] [PubMed]
  12. X. Zhou, P. Bedggood, B. Bui, C. T. O. Nguyen, Z. He, and A. Metha, “Contrast-based sensorless adaptive optics for retinal imaging,” Biomed. Opt. Express 6(9), 3577–3595 (2015).
    [Crossref] [PubMed]
  13. D. J. Wahl, Y. Jian, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, “Wavefront sensorless adaptive optics fluorescence biomicroscope for in vivo retinal imaging in mice,” Biomed. Opt. Express 7(1), 1–12 (2015).
    [Crossref] [PubMed]
  14. C. Alt, D. P. Biss, N. Tajouri, T. C. Jakobs, and C. P. Lin, “An adaptive-optics scanning laser ophthalmoscope for imaging murine retinal microstructure,” Proc. SPIE 7550, 755019 (2010).
    [Crossref]
  15. D. J. Wahl, C. Huang, S. Bonora, Y. Jian, and M. V. Sarunic, “Pupil segmentation adaptive optics for invivo mouse retinal fluorescence imaging,” Opt. Lett. 42(7), 1365–1368 (2017).
    [Crossref] [PubMed]
  16. Y. N. Sulai and A. Dubra, “Non-common path aberration correction in an adaptive optics scanning ophthalmoscope,” Biomed. Opt. Express 5(9), 3059–3073 (2014).
    [Crossref] [PubMed]
  17. D. J. Wahl, R. Ng, M. J. Ju, Y. Jian, and M. V. Sarunic, “Sensorless adaptive optics multimodal en-face small animal retinal imaging,” Biomed. Opt. Express 10(1), 252–267 (2018).
    [Crossref] [PubMed]
  18. P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).
  19. J. Mocci, M. Quintavalla, C. Trestino, S. Bonora, and R. Muradore, “A multi-platform CPU-based architecture for cost-Effective adaptive optics systems,” IEEE Trans. Industr. Inform. 14(10), 4431–4439 (2018).
    [Crossref]
  20. P. Pozzi, D. Wilding, O. Soloviev, H. Verstraete, L. Bliek, G. Vdovin, and M. Verhaegen, “High speed wavefront sensorless aberration correction in digital micromirror based confocal microscopy,” Opt. Express 25(2), 949–959 (2017).
    [Crossref] [PubMed]
  21. S. Bonora and R. J. Zawadzki, “Wavefront sensorless modal deformable mirror correction in adaptive optics: optical coherence tomography,” Opt. Lett. 38(22), 4801–4804 (2013).
    [Crossref] [PubMed]
  22. R. A. Muller and A. Buffington, “Real-time correction of atmospherically degraded telescope images through image sharpening,” J. Opt. Soc. Am. 64(9), 1200–1210 (1974).
    [Crossref]
  23. D. Debarre, M. J. Booth, and T. Wilson, “Image based adaptive optics through optimisation of low spatial frequencies,” Opt. Express 15(13), 8176–8190 (2007).
    [Crossref] [PubMed]
  24. L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, and R. WebbVSIA Standards Taskforce Members. Vision science and its applications, “Standards for reporting the optical aberrations of eyes,” J. Refract. Surg. 18(5), S652–S660 (2002).
    [PubMed]
  25. G. Palczewska, Z. Dong, M. Golczak, J. J. Hunter, D. R. Williams, N. S. Alexander, and K. Palczewski, “Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye,” Nat. Med. 20(7), 785–789 (2014).
    [Crossref] [PubMed]
  26. B. Wang and M. J. Booth, “Optimum deformable mirror modes for sensorless adaptive optics,” Opt. Commun. 282(23), 4467–4474 (2009).
    [Crossref]
  27. J. A. Kubby, Adaptive Optics for Biological Imaging (CRC Press, 2013).
  28. C. K. Sheehy, Q. Yang, D. W. Arathorn, P. Tiruveedhula, J. F. de Boer, and A. Roorda, “High-speed, image-based eye tracking with a scanning laser ophthalmoscope,” Biomed. Opt. Express 3(10), 2611–2622 (2012).
    [Crossref] [PubMed]
  29. H. Hofer, N. Sredar, H. Queener, C. Li, and J. Porter, “Wavefront sensorless adaptive optics ophthalmoscopy in the human eye,” Opt. Express 19(15), 14160–14171 (2011).
    [Crossref] [PubMed]
  30. T. DuBose, D. Nankivil, F. LaRocca, G. Waterman, K. Hagan, J. Polans, B. Keller, D. Tran-Viet, L. Vajzovic, A. N. Kuo, C. A. Toth, J. A. Izatt, and S. Farsiu, “Handheld adaptive optics scanning laser ophthalmoscope,” Optica 5(9), 1027–1036 (2018).
    [Crossref]
  31. S. Zommer, E. N. Ribak, S. G. Lipson, and J. Adler, “Simulated annealing in ocular adaptive optics,” Opt. Lett. 31(7), 939–941 (2006).
    [Crossref] [PubMed]
  32. M. Booth, “Wave front sensor-less adaptive optics: a model-based approach using sphere packings,” Opt. Express 14(4), 1339–1352 (2006).
    [Crossref] [PubMed]
  33. H. R. G. W. Verstraete, S. Wahls, J. Kalkman, and M. Verhaegen, “Model-based sensor-less wavefront aberration correction in optical coherence tomography,” Opt. Lett. 40(24), 5722–5725 (2015).
    [Crossref] [PubMed]
  34. N. Ji, “Adaptive optical fluorescence microscopy,” Nat. Methods 14(4), 374–380 (2017).
    [Crossref] [PubMed]
  35. J. Polans, B. Keller, O. M. Carrasco-Zevallos, F. LaRocca, E. Cole, H. E. Whitson, E. M. Lad, S. Farsiu, and J. A. Izatt, “Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions,” Biomed. Opt. Express 8(1), 16–37 (2016).
    [Crossref] [PubMed]
  36. A. Facomprez, E. Beaurepaire, and D. Débarre, “Accuracy of correction in modal sensorless adaptive optics,” Opt. Express 20(3), 2598–2612 (2012).
    [Crossref] [PubMed]
  37. C. Bourgenot, C. D. Saunter, G. D. Love, and J. M. Girkin, “Comparison of closed loop and sensorless adaptive optics in widefield optical microscopy,” J. Eur. Opt. Soc. 8, 13027 (2013).
    [Crossref]
  38. P. Zhang, M. Goswami, R. J. Zawadzki, and E. N. Pugh, “The Photosensitivity of Rhodopsin Bleaching and Light-Induced Increases of Fundus Reflectance in Mice Measured In Vivo With Scanning Laser Ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 57(8), 3650–3664 (2016).
    [Crossref] [PubMed]
  39. G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
    [Crossref] [PubMed]
  40. Y. Jian, J. Xu, M. A. Gradowski, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, “Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice,” Biomed. Opt. Express 5(2), 547–559 (2014).
    [Crossref] [PubMed]
  41. X. Tao, O. Azucena, M. Fu, Y. Zuo, D. C. Chen, and J. Kubby, “Adaptive optics microscopy with direct wavefront sensing using fluorescent protein guide stars,” Opt. Lett. 36(17), 3389–3391 (2011).
    [Crossref] [PubMed]
  42. M. Rueckel, J. A. Mack-Bucher, and W. Denk, “Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing,” Proc. Natl. Acad. Sci. U.S.A. 103(46), 17137–17142 (2006).
    [Crossref] [PubMed]
  43. M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, “Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging,” Sci. Rep. 6(1), 32223 (2016).
    [Crossref] [PubMed]
  44. R. Tyson, Principles of Adaptive Optics (CRC Press, 2010).
  45. M. Kasper, E. Fedrigo, D. P. Looze, H. Bonnet, L. Ivanescu, and S. Oberti, “Fast calibration of high-order adaptive optics systems,” J. Opt. Soc. Am. A 21(6), 1004–1008 (2004).
    [Crossref] [PubMed]
  46. N. S. Alexander, G. Palczewska, P. Stremplewski, M. Wojtkowski, T. S. Kern, and K. Palczewski, “Image registration and averaging of low laser power two-photon fluorescence images of mouse retina,” Biomed. Opt. Express 7(7), 2671–2691 (2016).
    [Crossref] [PubMed]

2018 (4)

D. J. Wahl, R. Ng, M. J. Ju, Y. Jian, and M. V. Sarunic, “Sensorless adaptive optics multimodal en-face small animal retinal imaging,” Biomed. Opt. Express 10(1), 252–267 (2018).
[Crossref] [PubMed]

P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).

J. Mocci, M. Quintavalla, C. Trestino, S. Bonora, and R. Muradore, “A multi-platform CPU-based architecture for cost-Effective adaptive optics systems,” IEEE Trans. Industr. Inform. 14(10), 4431–4439 (2018).
[Crossref]

T. DuBose, D. Nankivil, F. LaRocca, G. Waterman, K. Hagan, J. Polans, B. Keller, D. Tran-Viet, L. Vajzovic, A. N. Kuo, C. A. Toth, J. A. Izatt, and S. Farsiu, “Handheld adaptive optics scanning laser ophthalmoscope,” Optica 5(9), 1027–1036 (2018).
[Crossref]

2017 (4)

N. Ji, “Adaptive optical fluorescence microscopy,” Nat. Methods 14(4), 374–380 (2017).
[Crossref] [PubMed]

D. J. Wahl, C. Huang, S. Bonora, Y. Jian, and M. V. Sarunic, “Pupil segmentation adaptive optics for invivo mouse retinal fluorescence imaging,” Opt. Lett. 42(7), 1365–1368 (2017).
[Crossref] [PubMed]

P. Pozzi, D. Wilding, O. Soloviev, H. Verstraete, L. Bliek, G. Vdovin, and M. Verhaegen, “High speed wavefront sensorless aberration correction in digital micromirror based confocal microscopy,” Opt. Express 25(2), 949–959 (2017).
[Crossref] [PubMed]

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

2016 (4)

J. Polans, B. Keller, O. M. Carrasco-Zevallos, F. LaRocca, E. Cole, H. E. Whitson, E. M. Lad, S. Farsiu, and J. A. Izatt, “Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions,” Biomed. Opt. Express 8(1), 16–37 (2016).
[Crossref] [PubMed]

P. Zhang, M. Goswami, R. J. Zawadzki, and E. N. Pugh, “The Photosensitivity of Rhodopsin Bleaching and Light-Induced Increases of Fundus Reflectance in Mice Measured In Vivo With Scanning Laser Ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 57(8), 3650–3664 (2016).
[Crossref] [PubMed]

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, “Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging,” Sci. Rep. 6(1), 32223 (2016).
[Crossref] [PubMed]

N. S. Alexander, G. Palczewska, P. Stremplewski, M. Wojtkowski, T. S. Kern, and K. Palczewski, “Image registration and averaging of low laser power two-photon fluorescence images of mouse retina,” Biomed. Opt. Express 7(7), 2671–2691 (2016).
[Crossref] [PubMed]

2015 (5)

2014 (4)

M. J. Booth, “Adaptive optical microscopy: the ongoing quest for a perfect image,” Light Sci. Appl. 3(4), 165 (2014).
[Crossref]

Y. N. Sulai and A. Dubra, “Non-common path aberration correction in an adaptive optics scanning ophthalmoscope,” Biomed. Opt. Express 5(9), 3059–3073 (2014).
[Crossref] [PubMed]

G. Palczewska, Z. Dong, M. Golczak, J. J. Hunter, D. R. Williams, N. S. Alexander, and K. Palczewski, “Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye,” Nat. Med. 20(7), 785–789 (2014).
[Crossref] [PubMed]

Y. Jian, J. Xu, M. A. Gradowski, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, “Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice,” Biomed. Opt. Express 5(2), 547–559 (2014).
[Crossref] [PubMed]

2013 (5)

C. Bourgenot, C. D. Saunter, G. D. Love, and J. M. Girkin, “Comparison of closed loop and sensorless adaptive optics in widefield optical microscopy,” J. Eur. Opt. Soc. 8, 13027 (2013).
[Crossref]

S. Bonora and R. J. Zawadzki, “Wavefront sensorless modal deformable mirror correction in adaptive optics: optical coherence tomography,” Opt. Lett. 38(22), 4801–4804 (2013).
[Crossref] [PubMed]

J. Schallek, Y. Geng, H. Nguyen, and D. R. Williams, “Morphology and topography of retinal pericytes in the living mouse retina using in vivo adaptive optics imaging and ex vivo characterization,” Invest. Ophthalmol. Vis. Sci. 54(13), 8237–8250 (2013).
[Crossref] [PubMed]

L. Yin, Y. Geng, F. Osakada, R. Sharma, A. H. Cetin, E. M. Callaway, D. R. Williams, and W. H. Merigan, “Imaging light responses of retinal ganglion cells in the living mouse eye,” J. Neurophysiol. 109(9), 2415–2421 (2013).
[Crossref] [PubMed]

R. Sharma, L. Yin, Y. Geng, W. H. Merigan, G. Palczewska, K. Palczewski, D. R. Williams, and J. J. Hunter, “In vivo two-photon imaging of the mouse retina,” Biomed. Opt. Express 4(8), 1285–1293 (2013).
[Crossref] [PubMed]

2012 (4)

2011 (3)

2010 (2)

N. Ji, D. E. Milkie, and E. Betzig, “Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues,” Nat. Methods 7(2), 141–147 (2010).
[Crossref] [PubMed]

C. Alt, D. P. Biss, N. Tajouri, T. C. Jakobs, and C. P. Lin, “An adaptive-optics scanning laser ophthalmoscope for imaging murine retinal microstructure,” Proc. SPIE 7550, 755019 (2010).
[Crossref]

2009 (2)

B. Wang and M. J. Booth, “Optimum deformable mirror modes for sensorless adaptive optics,” Opt. Commun. 282(23), 4467–4474 (2009).
[Crossref]

G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
[Crossref] [PubMed]

2007 (1)

2006 (3)

2004 (1)

2002 (1)

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, and R. WebbVSIA Standards Taskforce Members. Vision science and its applications, “Standards for reporting the optical aberrations of eyes,” J. Refract. Surg. 18(5), S652–S660 (2002).
[PubMed]

1974 (1)

Adler, J.

Ahmad, K.

Alexander, N. S.

N. S. Alexander, G. Palczewska, P. Stremplewski, M. Wojtkowski, T. S. Kern, and K. Palczewski, “Image registration and averaging of low laser power two-photon fluorescence images of mouse retina,” Biomed. Opt. Express 7(7), 2671–2691 (2016).
[Crossref] [PubMed]

G. Palczewska, Z. Dong, M. Golczak, J. J. Hunter, D. R. Williams, N. S. Alexander, and K. Palczewski, “Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye,” Nat. Med. 20(7), 785–789 (2014).
[Crossref] [PubMed]

Alt, C.

C. Alt, D. P. Biss, N. Tajouri, T. C. Jakobs, and C. P. Lin, “An adaptive-optics scanning laser ophthalmoscope for imaging murine retinal microstructure,” Proc. SPIE 7550, 755019 (2010).
[Crossref]

Applegate, R. A.

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, and R. WebbVSIA Standards Taskforce Members. Vision science and its applications, “Standards for reporting the optical aberrations of eyes,” J. Refract. Surg. 18(5), S652–S660 (2002).
[PubMed]

Arathorn, D. W.

Artal, P.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Atchison, D. A.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Azucena, O.

Beaurepaire, E.

Beck, S. C.

G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
[Crossref] [PubMed]

Bedggood, P.

Betzig, E.

K. Wang, W. Sun, C. T. Richie, B. K. Harvey, E. Betzig, and N. Ji, “Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue,” Nat. Commun. 6(1), 7276 (2015).
[Crossref] [PubMed]

N. Ji, D. E. Milkie, and E. Betzig, “Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues,” Nat. Methods 7(2), 141–147 (2010).
[Crossref] [PubMed]

Biss, D. P.

C. Alt, D. P. Biss, N. Tajouri, T. C. Jakobs, and C. P. Lin, “An adaptive-optics scanning laser ophthalmoscope for imaging murine retinal microstructure,” Proc. SPIE 7550, 755019 (2010).
[Crossref]

Bliek, L.

Bonnet, H.

Bonora, S.

P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).

J. Mocci, M. Quintavalla, C. Trestino, S. Bonora, and R. Muradore, “A multi-platform CPU-based architecture for cost-Effective adaptive optics systems,” IEEE Trans. Industr. Inform. 14(10), 4431–4439 (2018).
[Crossref]

D. J. Wahl, C. Huang, S. Bonora, Y. Jian, and M. V. Sarunic, “Pupil segmentation adaptive optics for invivo mouse retinal fluorescence imaging,” Opt. Lett. 42(7), 1365–1368 (2017).
[Crossref] [PubMed]

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, “Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging,” Sci. Rep. 6(1), 32223 (2016).
[Crossref] [PubMed]

D. J. Wahl, Y. Jian, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, “Wavefront sensorless adaptive optics fluorescence biomicroscope for in vivo retinal imaging in mice,” Biomed. Opt. Express 7(1), 1–12 (2015).
[Crossref] [PubMed]

Y. Jian, J. Xu, M. A. Gradowski, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, “Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice,” Biomed. Opt. Express 5(2), 547–559 (2014).
[Crossref] [PubMed]

S. Bonora and R. J. Zawadzki, “Wavefront sensorless modal deformable mirror correction in adaptive optics: optical coherence tomography,” Opt. Lett. 38(22), 4801–4804 (2013).
[Crossref] [PubMed]

Booth, M.

Booth, M. J.

M. J. Booth, “Adaptive optical microscopy: the ongoing quest for a perfect image,” Light Sci. Appl. 3(4), 165 (2014).
[Crossref]

B. Wang and M. J. Booth, “Optimum deformable mirror modes for sensorless adaptive optics,” Opt. Commun. 282(23), 4467–4474 (2009).
[Crossref]

D. Debarre, M. J. Booth, and T. Wilson, “Image based adaptive optics through optimisation of low spatial frequencies,” Opt. Express 15(13), 8176–8190 (2007).
[Crossref] [PubMed]

Bourgenot, C.

C. Bourgenot, C. D. Saunter, G. D. Love, and J. M. Girkin, “Comparison of closed loop and sensorless adaptive optics in widefield optical microscopy,” J. Eur. Opt. Soc. 8, 13027 (2013).
[Crossref]

Buffington, A.

Bui, B.

Burns, M. E.

Burns, S. A.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Callaway, E. M.

L. Yin, Y. Geng, F. Osakada, R. Sharma, A. H. Cetin, E. M. Callaway, D. R. Williams, and W. H. Merigan, “Imaging light responses of retinal ganglion cells in the living mouse eye,” J. Neurophysiol. 109(9), 2415–2421 (2013).
[Crossref] [PubMed]

Campbell, M.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Carrasco-Zevallos, O. M.

Carroll, J.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Cetin, A. H.

L. Yin, Y. Geng, F. Osakada, R. Sharma, A. H. Cetin, E. M. Callaway, D. R. Williams, and W. H. Merigan, “Imaging light responses of retinal ganglion cells in the living mouse eye,” J. Neurophysiol. 109(9), 2415–2421 (2013).
[Crossref] [PubMed]

Chen, D. C.

Choi, S. S.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Cole, E.

Cua, M.

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, “Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging,” Sci. Rep. 6(1), 32223 (2016).
[Crossref] [PubMed]

de Boer, J. F.

Debarre, D.

Débarre, D.

Denk, W.

M. Rueckel, J. A. Mack-Bucher, and W. Denk, “Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing,” Proc. Natl. Acad. Sci. U.S.A. 103(46), 17137–17142 (2006).
[Crossref] [PubMed]

Doble, N.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Dong, Z.

G. Palczewska, Z. Dong, M. Golczak, J. J. Hunter, D. R. Williams, N. S. Alexander, and K. Palczewski, “Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye,” Nat. Med. 20(7), 785–789 (2014).
[Crossref] [PubMed]

Dubis, A. M.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

DuBose, T.

Dubra, A.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Y. N. Sulai and A. Dubra, “Non-common path aberration correction in an adaptive optics scanning ophthalmoscope,” Biomed. Opt. Express 5(9), 3059–3073 (2014).
[Crossref] [PubMed]

Y. Geng, A. Dubra, L. Yin, W. H. Merigan, R. Sharma, R. T. Libby, and D. R. Williams, “Adaptive optics retinal imaging in the living mouse eye,” Biomed. Opt. Express 3(4), 715–734 (2012).
[Crossref] [PubMed]

Y. Geng, L. A. Schery, R. Sharma, A. Dubra, K. Ahmad, R. T. Libby, and D. R. Williams, “Optical properties of the mouse eye,” Biomed. Opt. Express 2(4), 717–738 (2011).
[Crossref] [PubMed]

Elsner, A.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Facomprez, A.

Farsiu, S.

Fedrigo, E.

Fischer, M. D.

G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
[Crossref] [PubMed]

Flannery, J. G.

Fu, M.

Geng, Y.

L. Yin, Y. Geng, F. Osakada, R. Sharma, A. H. Cetin, E. M. Callaway, D. R. Williams, and W. H. Merigan, “Imaging light responses of retinal ganglion cells in the living mouse eye,” J. Neurophysiol. 109(9), 2415–2421 (2013).
[Crossref] [PubMed]

J. Schallek, Y. Geng, H. Nguyen, and D. R. Williams, “Morphology and topography of retinal pericytes in the living mouse retina using in vivo adaptive optics imaging and ex vivo characterization,” Invest. Ophthalmol. Vis. Sci. 54(13), 8237–8250 (2013).
[Crossref] [PubMed]

R. Sharma, L. Yin, Y. Geng, W. H. Merigan, G. Palczewska, K. Palczewski, D. R. Williams, and J. J. Hunter, “In vivo two-photon imaging of the mouse retina,” Biomed. Opt. Express 4(8), 1285–1293 (2013).
[Crossref] [PubMed]

Y. Geng, A. Dubra, L. Yin, W. H. Merigan, R. Sharma, R. T. Libby, and D. R. Williams, “Adaptive optics retinal imaging in the living mouse eye,” Biomed. Opt. Express 3(4), 715–734 (2012).
[Crossref] [PubMed]

Y. Geng, L. A. Schery, R. Sharma, A. Dubra, K. Ahmad, R. T. Libby, and D. R. Williams, “Optical properties of the mouse eye,” Biomed. Opt. Express 2(4), 717–738 (2011).
[Crossref] [PubMed]

Girkin, J. M.

C. Bourgenot, C. D. Saunter, G. D. Love, and J. M. Girkin, “Comparison of closed loop and sensorless adaptive optics in widefield optical microscopy,” J. Eur. Opt. Soc. 8, 13027 (2013).
[Crossref]

Golczak, M.

G. Palczewska, Z. Dong, M. Golczak, J. J. Hunter, D. R. Williams, N. S. Alexander, and K. Palczewski, “Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye,” Nat. Med. 20(7), 785–789 (2014).
[Crossref] [PubMed]

Goswami, M.

P. Zhang, M. Goswami, R. J. Zawadzki, and E. N. Pugh, “The Photosensitivity of Rhodopsin Bleaching and Light-Induced Increases of Fundus Reflectance in Mice Measured In Vivo With Scanning Laser Ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 57(8), 3650–3664 (2016).
[Crossref] [PubMed]

R. J. Zawadzki, P. Zhang, A. Zam, E. B. Miller, M. Goswami, X. Wang, R. S. Jonnal, S. H. Lee, D. Y. Kim, J. G. Flannery, J. S. Werner, M. E. Burns, and E. N. Pugh, “Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina,” Biomed. Opt. Express 6(6), 2191–2210 (2015).
[Crossref] [PubMed]

Gradowski, M. A.

Grimm, C.

G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
[Crossref] [PubMed]

Hagan, K.

Hampson, K. M.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Harvey, B. K.

K. Wang, W. Sun, C. T. Richie, B. K. Harvey, E. Betzig, and N. Ji, “Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue,” Nat. Commun. 6(1), 7276 (2015).
[Crossref] [PubMed]

He, Z.

Hofer, H.

Huang, C.

Huber, G.

G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
[Crossref] [PubMed]

Humphries, P.

G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
[Crossref] [PubMed]

Hunter, J.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Hunter, J. J.

G. Palczewska, Z. Dong, M. Golczak, J. J. Hunter, D. R. Williams, N. S. Alexander, and K. Palczewski, “Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye,” Nat. Med. 20(7), 785–789 (2014).
[Crossref] [PubMed]

R. Sharma, L. Yin, Y. Geng, W. H. Merigan, G. Palczewska, K. Palczewski, D. R. Williams, and J. J. Hunter, “In vivo two-photon imaging of the mouse retina,” Biomed. Opt. Express 4(8), 1285–1293 (2013).
[Crossref] [PubMed]

Ivanescu, L.

Izatt, J. A.

Jakobs, T. C.

C. Alt, D. P. Biss, N. Tajouri, T. C. Jakobs, and C. P. Lin, “An adaptive-optics scanning laser ophthalmoscope for imaging murine retinal microstructure,” Proc. SPIE 7550, 755019 (2010).
[Crossref]

Ji, N.

N. Ji, “Adaptive optical fluorescence microscopy,” Nat. Methods 14(4), 374–380 (2017).
[Crossref] [PubMed]

K. Wang, W. Sun, C. T. Richie, B. K. Harvey, E. Betzig, and N. Ji, “Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue,” Nat. Commun. 6(1), 7276 (2015).
[Crossref] [PubMed]

N. Ji, D. E. Milkie, and E. Betzig, “Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues,” Nat. Methods 7(2), 141–147 (2010).
[Crossref] [PubMed]

Jian, Y.

Jonnal, R.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Jonnal, R. S.

Ju, M. J.

Kalkman, J.

Kasper, M.

Keller, B.

Kern, T. S.

Kim, D. Y.

Kubby, J.

Kuo, A. N.

Lad, E. M.

LaRocca, F.

Lee, S.

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, “Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging,” Sci. Rep. 6(1), 32223 (2016).
[Crossref] [PubMed]

Lee, S. H.

Legras, R.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Li, C.

Libby, R. T.

Lin, C. P.

C. Alt, D. P. Biss, N. Tajouri, T. C. Jakobs, and C. P. Lin, “An adaptive-optics scanning laser ophthalmoscope for imaging murine retinal microstructure,” Proc. SPIE 7550, 755019 (2010).
[Crossref]

Lipson, S. G.

Looze, D. P.

Love, G. D.

C. Bourgenot, C. D. Saunter, G. D. Love, and J. M. Girkin, “Comparison of closed loop and sensorless adaptive optics in widefield optical microscopy,” J. Eur. Opt. Soc. 8, 13027 (2013).
[Crossref]

Lundstrom, L.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Mack-Bucher, J. A.

M. Rueckel, J. A. Mack-Bucher, and W. Denk, “Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing,” Proc. Natl. Acad. Sci. U.S.A. 103(46), 17137–17142 (2006).
[Crossref] [PubMed]

Manna, S. K.

P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).

Marcos, S.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Meleppat, R. K.

P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).

Merigan, W. H.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

L. Yin, Y. Geng, F. Osakada, R. Sharma, A. H. Cetin, E. M. Callaway, D. R. Williams, and W. H. Merigan, “Imaging light responses of retinal ganglion cells in the living mouse eye,” J. Neurophysiol. 109(9), 2415–2421 (2013).
[Crossref] [PubMed]

R. Sharma, L. Yin, Y. Geng, W. H. Merigan, G. Palczewska, K. Palczewski, D. R. Williams, and J. J. Hunter, “In vivo two-photon imaging of the mouse retina,” Biomed. Opt. Express 4(8), 1285–1293 (2013).
[Crossref] [PubMed]

Y. Geng, A. Dubra, L. Yin, W. H. Merigan, R. Sharma, R. T. Libby, and D. R. Williams, “Adaptive optics retinal imaging in the living mouse eye,” Biomed. Opt. Express 3(4), 715–734 (2012).
[Crossref] [PubMed]

Metha, A.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

X. Zhou, P. Bedggood, B. Bui, C. T. O. Nguyen, Z. He, and A. Metha, “Contrast-based sensorless adaptive optics for retinal imaging,” Biomed. Opt. Express 6(9), 3577–3595 (2015).
[Crossref] [PubMed]

X. Zhou, P. Bedggood, and A. Metha, “Limitations to adaptive optics image quality in rodent eyes,” Biomed. Opt. Express 3(8), 1811–1824 (2012).
[Crossref] [PubMed]

Milkie, D. E.

N. Ji, D. E. Milkie, and E. Betzig, “Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues,” Nat. Methods 7(2), 141–147 (2010).
[Crossref] [PubMed]

Miller, D. T.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Miller, E. B.

Mocci, J.

P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).

J. Mocci, M. Quintavalla, C. Trestino, S. Bonora, and R. Muradore, “A multi-platform CPU-based architecture for cost-Effective adaptive optics systems,” IEEE Trans. Industr. Inform. 14(10), 4431–4439 (2018).
[Crossref]

Muller, R. A.

Muradore, R.

J. Mocci, M. Quintavalla, C. Trestino, S. Bonora, and R. Muradore, “A multi-platform CPU-based architecture for cost-Effective adaptive optics systems,” IEEE Trans. Industr. Inform. 14(10), 4431–4439 (2018).
[Crossref]

P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).

Nankivil, D.

Ng, R.

Nguyen, C. T. O.

Nguyen, H.

J. Schallek, Y. Geng, H. Nguyen, and D. R. Williams, “Morphology and topography of retinal pericytes in the living mouse retina using in vivo adaptive optics imaging and ex vivo characterization,” Invest. Ophthalmol. Vis. Sci. 54(13), 8237–8250 (2013).
[Crossref] [PubMed]

Oberti, S.

Osakada, F.

L. Yin, Y. Geng, F. Osakada, R. Sharma, A. H. Cetin, E. M. Callaway, D. R. Williams, and W. H. Merigan, “Imaging light responses of retinal ganglion cells in the living mouse eye,” J. Neurophysiol. 109(9), 2415–2421 (2013).
[Crossref] [PubMed]

Palczewska, G.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

N. S. Alexander, G. Palczewska, P. Stremplewski, M. Wojtkowski, T. S. Kern, and K. Palczewski, “Image registration and averaging of low laser power two-photon fluorescence images of mouse retina,” Biomed. Opt. Express 7(7), 2671–2691 (2016).
[Crossref] [PubMed]

G. Palczewska, Z. Dong, M. Golczak, J. J. Hunter, D. R. Williams, N. S. Alexander, and K. Palczewski, “Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye,” Nat. Med. 20(7), 785–789 (2014).
[Crossref] [PubMed]

R. Sharma, L. Yin, Y. Geng, W. H. Merigan, G. Palczewska, K. Palczewski, D. R. Williams, and J. J. Hunter, “In vivo two-photon imaging of the mouse retina,” Biomed. Opt. Express 4(8), 1285–1293 (2013).
[Crossref] [PubMed]

Palczewski, K.

Paques, M.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Paquet-Durand, F.

G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
[Crossref] [PubMed]

Polans, J.

Porter, J.

Pozzi, P.

Pugh, E. N.

P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).

P. Zhang, M. Goswami, R. J. Zawadzki, and E. N. Pugh, “The Photosensitivity of Rhodopsin Bleaching and Light-Induced Increases of Fundus Reflectance in Mice Measured In Vivo With Scanning Laser Ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 57(8), 3650–3664 (2016).
[Crossref] [PubMed]

R. J. Zawadzki, P. Zhang, A. Zam, E. B. Miller, M. Goswami, X. Wang, R. S. Jonnal, S. H. Lee, D. Y. Kim, J. G. Flannery, J. S. Werner, M. E. Burns, and E. N. Pugh, “Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina,” Biomed. Opt. Express 6(6), 2191–2210 (2015).
[Crossref] [PubMed]

Queener, H.

Quintavalla, M.

J. Mocci, M. Quintavalla, C. Trestino, S. Bonora, and R. Muradore, “A multi-platform CPU-based architecture for cost-Effective adaptive optics systems,” IEEE Trans. Industr. Inform. 14(10), 4431–4439 (2018).
[Crossref]

P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).

Redmond, T. M.

G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
[Crossref] [PubMed]

Ribak, E. N.

Richie, C. T.

K. Wang, W. Sun, C. T. Richie, B. K. Harvey, E. Betzig, and N. Ji, “Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue,” Nat. Commun. 6(1), 7276 (2015).
[Crossref] [PubMed]

Roorda, A.

Rueckel, M.

M. Rueckel, J. A. Mack-Bucher, and W. Denk, “Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing,” Proc. Natl. Acad. Sci. U.S.A. 103(46), 17137–17142 (2006).
[Crossref] [PubMed]

Sahaboglu-Tekgoz, A.

G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
[Crossref] [PubMed]

Sarunic, M. V.

Saunter, C. D.

C. Bourgenot, C. D. Saunter, G. D. Love, and J. M. Girkin, “Comparison of closed loop and sensorless adaptive optics in widefield optical microscopy,” J. Eur. Opt. Soc. 8, 13027 (2013).
[Crossref]

Schallek, J.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

J. Schallek, Y. Geng, H. Nguyen, and D. R. Williams, “Morphology and topography of retinal pericytes in the living mouse retina using in vivo adaptive optics imaging and ex vivo characterization,” Invest. Ophthalmol. Vis. Sci. 54(13), 8237–8250 (2013).
[Crossref] [PubMed]

Schery, L. A.

Schwiegerling, J. T.

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, and R. WebbVSIA Standards Taskforce Members. Vision science and its applications, “Standards for reporting the optical aberrations of eyes,” J. Refract. Surg. 18(5), S652–S660 (2002).
[PubMed]

Seeliger, M. W.

G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
[Crossref] [PubMed]

Sharma, R.

Sheehy, C. K.

Sincich, L. C.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Smithson, H. E.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Soloviev, O.

Sredar, N.

Stremplewski, P.

Sulai, Y. N.

Sun, W.

K. Wang, W. Sun, C. T. Richie, B. K. Harvey, E. Betzig, and N. Ji, “Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue,” Nat. Commun. 6(1), 7276 (2015).
[Crossref] [PubMed]

Tajouri, N.

C. Alt, D. P. Biss, N. Tajouri, T. C. Jakobs, and C. P. Lin, “An adaptive-optics scanning laser ophthalmoscope for imaging murine retinal microstructure,” Proc. SPIE 7550, 755019 (2010).
[Crossref]

Tao, X.

Thibos, L. N.

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, and R. WebbVSIA Standards Taskforce Members. Vision science and its applications, “Standards for reporting the optical aberrations of eyes,” J. Refract. Surg. 18(5), S652–S660 (2002).
[PubMed]

Tiruveedhula, P.

Toth, C. A.

Tran-Viet, D.

Trestino, C.

J. Mocci, M. Quintavalla, C. Trestino, S. Bonora, and R. Muradore, “A multi-platform CPU-based architecture for cost-Effective adaptive optics systems,” IEEE Trans. Industr. Inform. 14(10), 4431–4439 (2018).
[Crossref]

Vajzovic, L.

Vdovin, G.

Verhaegen, M.

Verstraete, H.

Verstraete, H. R. G. W.

Wahl, D. J.

D. J. Wahl, R. Ng, M. J. Ju, Y. Jian, and M. V. Sarunic, “Sensorless adaptive optics multimodal en-face small animal retinal imaging,” Biomed. Opt. Express 10(1), 252–267 (2018).
[Crossref] [PubMed]

P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).

D. J. Wahl, C. Huang, S. Bonora, Y. Jian, and M. V. Sarunic, “Pupil segmentation adaptive optics for invivo mouse retinal fluorescence imaging,” Opt. Lett. 42(7), 1365–1368 (2017).
[Crossref] [PubMed]

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, “Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging,” Sci. Rep. 6(1), 32223 (2016).
[Crossref] [PubMed]

D. J. Wahl, Y. Jian, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, “Wavefront sensorless adaptive optics fluorescence biomicroscope for in vivo retinal imaging in mice,” Biomed. Opt. Express 7(1), 1–12 (2015).
[Crossref] [PubMed]

Wahls, S.

Wang, B.

B. Wang and M. J. Booth, “Optimum deformable mirror modes for sensorless adaptive optics,” Opt. Commun. 282(23), 4467–4474 (2009).
[Crossref]

Wang, K.

K. Wang, W. Sun, C. T. Richie, B. K. Harvey, E. Betzig, and N. Ji, “Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue,” Nat. Commun. 6(1), 7276 (2015).
[Crossref] [PubMed]

Wang, X.

Waterman, G.

Webb, R.

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, and R. WebbVSIA Standards Taskforce Members. Vision science and its applications, “Standards for reporting the optical aberrations of eyes,” J. Refract. Surg. 18(5), S652–S660 (2002).
[PubMed]

Wenzel, A.

G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
[Crossref] [PubMed]

Werner, J. S.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

R. J. Zawadzki, P. Zhang, A. Zam, E. B. Miller, M. Goswami, X. Wang, R. S. Jonnal, S. H. Lee, D. Y. Kim, J. G. Flannery, J. S. Werner, M. E. Burns, and E. N. Pugh, “Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina,” Biomed. Opt. Express 6(6), 2191–2210 (2015).
[Crossref] [PubMed]

Whitson, H. E.

Wilding, D.

Williams, D. R.

G. Palczewska, Z. Dong, M. Golczak, J. J. Hunter, D. R. Williams, N. S. Alexander, and K. Palczewski, “Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye,” Nat. Med. 20(7), 785–789 (2014).
[Crossref] [PubMed]

L. Yin, Y. Geng, F. Osakada, R. Sharma, A. H. Cetin, E. M. Callaway, D. R. Williams, and W. H. Merigan, “Imaging light responses of retinal ganglion cells in the living mouse eye,” J. Neurophysiol. 109(9), 2415–2421 (2013).
[Crossref] [PubMed]

J. Schallek, Y. Geng, H. Nguyen, and D. R. Williams, “Morphology and topography of retinal pericytes in the living mouse retina using in vivo adaptive optics imaging and ex vivo characterization,” Invest. Ophthalmol. Vis. Sci. 54(13), 8237–8250 (2013).
[Crossref] [PubMed]

R. Sharma, L. Yin, Y. Geng, W. H. Merigan, G. Palczewska, K. Palczewski, D. R. Williams, and J. J. Hunter, “In vivo two-photon imaging of the mouse retina,” Biomed. Opt. Express 4(8), 1285–1293 (2013).
[Crossref] [PubMed]

Y. Geng, A. Dubra, L. Yin, W. H. Merigan, R. Sharma, R. T. Libby, and D. R. Williams, “Adaptive optics retinal imaging in the living mouse eye,” Biomed. Opt. Express 3(4), 715–734 (2012).
[Crossref] [PubMed]

Y. Geng, L. A. Schery, R. Sharma, A. Dubra, K. Ahmad, R. T. Libby, and D. R. Williams, “Optical properties of the mouse eye,” Biomed. Opt. Express 2(4), 717–738 (2011).
[Crossref] [PubMed]

Wilson, T.

Wojtkowski, M.

Xu, J.

Yang, Q.

Yin, L.

Yoon, G.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Young, L. K.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Zam, A.

Zawadzki, R. J.

P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).

P. Zhang, M. Goswami, R. J. Zawadzki, and E. N. Pugh, “The Photosensitivity of Rhodopsin Bleaching and Light-Induced Increases of Fundus Reflectance in Mice Measured In Vivo With Scanning Laser Ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 57(8), 3650–3664 (2016).
[Crossref] [PubMed]

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, “Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging,” Sci. Rep. 6(1), 32223 (2016).
[Crossref] [PubMed]

R. J. Zawadzki, P. Zhang, A. Zam, E. B. Miller, M. Goswami, X. Wang, R. S. Jonnal, S. H. Lee, D. Y. Kim, J. G. Flannery, J. S. Werner, M. E. Burns, and E. N. Pugh, “Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina,” Biomed. Opt. Express 6(6), 2191–2210 (2015).
[Crossref] [PubMed]

D. J. Wahl, Y. Jian, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, “Wavefront sensorless adaptive optics fluorescence biomicroscope for in vivo retinal imaging in mice,” Biomed. Opt. Express 7(1), 1–12 (2015).
[Crossref] [PubMed]

Y. Jian, J. Xu, M. A. Gradowski, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, “Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice,” Biomed. Opt. Express 5(2), 547–559 (2014).
[Crossref] [PubMed]

S. Bonora and R. J. Zawadzki, “Wavefront sensorless modal deformable mirror correction in adaptive optics: optical coherence tomography,” Opt. Lett. 38(22), 4801–4804 (2013).
[Crossref] [PubMed]

Zhang, P.

P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).

P. Zhang, M. Goswami, R. J. Zawadzki, and E. N. Pugh, “The Photosensitivity of Rhodopsin Bleaching and Light-Induced Increases of Fundus Reflectance in Mice Measured In Vivo With Scanning Laser Ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 57(8), 3650–3664 (2016).
[Crossref] [PubMed]

R. J. Zawadzki, P. Zhang, A. Zam, E. B. Miller, M. Goswami, X. Wang, R. S. Jonnal, S. H. Lee, D. Y. Kim, J. G. Flannery, J. S. Werner, M. E. Burns, and E. N. Pugh, “Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina,” Biomed. Opt. Express 6(6), 2191–2210 (2015).
[Crossref] [PubMed]

Zhang, Y.

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Zhao, Y.

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, “Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging,” Sci. Rep. 6(1), 32223 (2016).
[Crossref] [PubMed]

Zhou, X.

Zommer, S.

Zuo, Y.

Biomed. Opt. Express (13)

Y. Geng, A. Dubra, L. Yin, W. H. Merigan, R. Sharma, R. T. Libby, and D. R. Williams, “Adaptive optics retinal imaging in the living mouse eye,” Biomed. Opt. Express 3(4), 715–734 (2012).
[Crossref] [PubMed]

R. Sharma, L. Yin, Y. Geng, W. H. Merigan, G. Palczewska, K. Palczewski, D. R. Williams, and J. J. Hunter, “In vivo two-photon imaging of the mouse retina,” Biomed. Opt. Express 4(8), 1285–1293 (2013).
[Crossref] [PubMed]

X. Zhou, P. Bedggood, and A. Metha, “Limitations to adaptive optics image quality in rodent eyes,” Biomed. Opt. Express 3(8), 1811–1824 (2012).
[Crossref] [PubMed]

Y. Geng, L. A. Schery, R. Sharma, A. Dubra, K. Ahmad, R. T. Libby, and D. R. Williams, “Optical properties of the mouse eye,” Biomed. Opt. Express 2(4), 717–738 (2011).
[Crossref] [PubMed]

R. J. Zawadzki, P. Zhang, A. Zam, E. B. Miller, M. Goswami, X. Wang, R. S. Jonnal, S. H. Lee, D. Y. Kim, J. G. Flannery, J. S. Werner, M. E. Burns, and E. N. Pugh, “Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina,” Biomed. Opt. Express 6(6), 2191–2210 (2015).
[Crossref] [PubMed]

X. Zhou, P. Bedggood, B. Bui, C. T. O. Nguyen, Z. He, and A. Metha, “Contrast-based sensorless adaptive optics for retinal imaging,” Biomed. Opt. Express 6(9), 3577–3595 (2015).
[Crossref] [PubMed]

D. J. Wahl, Y. Jian, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, “Wavefront sensorless adaptive optics fluorescence biomicroscope for in vivo retinal imaging in mice,” Biomed. Opt. Express 7(1), 1–12 (2015).
[Crossref] [PubMed]

Y. N. Sulai and A. Dubra, “Non-common path aberration correction in an adaptive optics scanning ophthalmoscope,” Biomed. Opt. Express 5(9), 3059–3073 (2014).
[Crossref] [PubMed]

D. J. Wahl, R. Ng, M. J. Ju, Y. Jian, and M. V. Sarunic, “Sensorless adaptive optics multimodal en-face small animal retinal imaging,” Biomed. Opt. Express 10(1), 252–267 (2018).
[Crossref] [PubMed]

C. K. Sheehy, Q. Yang, D. W. Arathorn, P. Tiruveedhula, J. F. de Boer, and A. Roorda, “High-speed, image-based eye tracking with a scanning laser ophthalmoscope,” Biomed. Opt. Express 3(10), 2611–2622 (2012).
[Crossref] [PubMed]

J. Polans, B. Keller, O. M. Carrasco-Zevallos, F. LaRocca, E. Cole, H. E. Whitson, E. M. Lad, S. Farsiu, and J. A. Izatt, “Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions,” Biomed. Opt. Express 8(1), 16–37 (2016).
[Crossref] [PubMed]

Y. Jian, J. Xu, M. A. Gradowski, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, “Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice,” Biomed. Opt. Express 5(2), 547–559 (2014).
[Crossref] [PubMed]

N. S. Alexander, G. Palczewska, P. Stremplewski, M. Wojtkowski, T. S. Kern, and K. Palczewski, “Image registration and averaging of low laser power two-photon fluorescence images of mouse retina,” Biomed. Opt. Express 7(7), 2671–2691 (2016).
[Crossref] [PubMed]

Exp. Eye Res. (1)

P. Zhang, J. Mocci, D. J. Wahl, R. K. Meleppat, S. K. Manna, M. Quintavalla, R. Muradore, M. V. Sarunic, S. Bonora, E. N. Pugh, and R. J. Zawadzki, “Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations,” Exp. Eye Res. 172, 86–93 (2018).

IEEE Trans. Industr. Inform. (1)

J. Mocci, M. Quintavalla, C. Trestino, S. Bonora, and R. Muradore, “A multi-platform CPU-based architecture for cost-Effective adaptive optics systems,” IEEE Trans. Industr. Inform. 14(10), 4431–4439 (2018).
[Crossref]

Invest. Ophthalmol. Vis. Sci. (3)

J. Schallek, Y. Geng, H. Nguyen, and D. R. Williams, “Morphology and topography of retinal pericytes in the living mouse retina using in vivo adaptive optics imaging and ex vivo characterization,” Invest. Ophthalmol. Vis. Sci. 54(13), 8237–8250 (2013).
[Crossref] [PubMed]

P. Zhang, M. Goswami, R. J. Zawadzki, and E. N. Pugh, “The Photosensitivity of Rhodopsin Bleaching and Light-Induced Increases of Fundus Reflectance in Mice Measured In Vivo With Scanning Laser Ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 57(8), 3650–3664 (2016).
[Crossref] [PubMed]

G. Huber, S. C. Beck, C. Grimm, A. Sahaboglu-Tekgoz, F. Paquet-Durand, A. Wenzel, P. Humphries, T. M. Redmond, M. W. Seeliger, and M. D. Fischer, “Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration,” Invest. Ophthalmol. Vis. Sci. 50(12), 5888–5895 (2009).
[Crossref] [PubMed]

J. Eur. Opt. Soc. (1)

C. Bourgenot, C. D. Saunter, G. D. Love, and J. M. Girkin, “Comparison of closed loop and sensorless adaptive optics in widefield optical microscopy,” J. Eur. Opt. Soc. 8, 13027 (2013).
[Crossref]

J. Neurophysiol. (1)

L. Yin, Y. Geng, F. Osakada, R. Sharma, A. H. Cetin, E. M. Callaway, D. R. Williams, and W. H. Merigan, “Imaging light responses of retinal ganglion cells in the living mouse eye,” J. Neurophysiol. 109(9), 2415–2421 (2013).
[Crossref] [PubMed]

J. Opt. Soc. Am. (1)

J. Opt. Soc. Am. A (1)

J. Refract. Surg. (1)

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, and R. WebbVSIA Standards Taskforce Members. Vision science and its applications, “Standards for reporting the optical aberrations of eyes,” J. Refract. Surg. 18(5), S652–S660 (2002).
[PubMed]

Light Sci. Appl. (1)

M. J. Booth, “Adaptive optical microscopy: the ongoing quest for a perfect image,” Light Sci. Appl. 3(4), 165 (2014).
[Crossref]

Nat. Commun. (1)

K. Wang, W. Sun, C. T. Richie, B. K. Harvey, E. Betzig, and N. Ji, “Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue,” Nat. Commun. 6(1), 7276 (2015).
[Crossref] [PubMed]

Nat. Med. (1)

G. Palczewska, Z. Dong, M. Golczak, J. J. Hunter, D. R. Williams, N. S. Alexander, and K. Palczewski, “Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye,” Nat. Med. 20(7), 785–789 (2014).
[Crossref] [PubMed]

Nat. Methods (2)

N. Ji, “Adaptive optical fluorescence microscopy,” Nat. Methods 14(4), 374–380 (2017).
[Crossref] [PubMed]

N. Ji, D. E. Milkie, and E. Betzig, “Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues,” Nat. Methods 7(2), 141–147 (2010).
[Crossref] [PubMed]

Opt. Commun. (1)

B. Wang and M. J. Booth, “Optimum deformable mirror modes for sensorless adaptive optics,” Opt. Commun. 282(23), 4467–4474 (2009).
[Crossref]

Opt. Express (5)

Opt. Lett. (5)

Optica (1)

Proc. Natl. Acad. Sci. U.S.A. (1)

M. Rueckel, J. A. Mack-Bucher, and W. Denk, “Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing,” Proc. Natl. Acad. Sci. U.S.A. 103(46), 17137–17142 (2006).
[Crossref] [PubMed]

Proc. SPIE (1)

C. Alt, D. P. Biss, N. Tajouri, T. C. Jakobs, and C. P. Lin, “An adaptive-optics scanning laser ophthalmoscope for imaging murine retinal microstructure,” Proc. SPIE 7550, 755019 (2010).
[Crossref]

Sci. Rep. (1)

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, “Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging,” Sci. Rep. 6(1), 32223 (2016).
[Crossref] [PubMed]

Vision Res. (1)

S. Marcos, J. S. Werner, S. A. Burns, W. H. Merigan, P. Artal, D. A. Atchison, K. M. Hampson, R. Legras, L. Lundstrom, G. Yoon, J. Carroll, S. S. Choi, N. Doble, A. M. Dubis, A. Dubra, A. Elsner, R. Jonnal, D. T. Miller, M. Paques, H. E. Smithson, L. K. Young, Y. Zhang, M. Campbell, J. Hunter, A. Metha, G. Palczewska, J. Schallek, and L. C. Sincich, “Vision science and adaptive optics, the state of the field,” Vision Res. 132, 3–33 (2017).
[Crossref] [PubMed]

Other (2)

J. A. Kubby, Adaptive Optics for Biological Imaging (CRC Press, 2013).

R. Tyson, Principles of Adaptive Optics (CRC Press, 2010).

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (9)

Fig. 1
Fig. 1 Phantom imaging of fluorescent beads and wavefront measurements during Wavefront Sensor Adaptive Optics (WFS AO) and Wavefront Sensorless Adaptive Optics (WFS-less AO). (a) Fluorescence images of 30 µm beads on white paper with a 100 mm focal length model eye before AO, after WFS AO, and after WFS-less AO. For the inset image before AO, the pixel intensity values were multiplied by 8, so the beads could be visualized. (b) The increase in the fluorescence image quality during the WFS-less AO optimization. (c) The wavefront RMS excluding defocus, tip and tilt during WFS AO correction. (d) The wavefront RMS excluding defocus, tip and tilt during WFS-less AO optimization. (e) The Zernike decomposition of the wavefront measured before and after each method of AO correction.
Fig. 2
Fig. 2 Imaging the mouse photoreceptor mosaic with Wavefront Sensor based Adaptive Optics (WFS AO) and Wavefront Sensorless Adaptive Optics (WFS-less AO). (a,b) Images after WFS AO and WFS-less AO. Scale bar: 10 µm. (c) The image quality improvement during WFS-less AO optimization. (d) The wavefront RMS during WFS-less AO optimization. (e) The Zernike decomposition of the wavefront measured before and after each method of AO.
Fig. 3
Fig. 3 SH-WFS measurements from an Albino mouse strain (BALB/cJ) retina. (a) The SH-WFS centroids of an albino mouse compared to a pigmented mouse. (b) The RMS of the wavefront measurement without defocus. (c) The image quality metric during WFS-less AO optimization.
Fig. 4
Fig. 4 Imaging the inner retina of an Albino mouse (BALB/cJ) with Wavefront Sensorless Adaptive Optics (WFS-less AO). Images of the retina vasculature before and after WFS-less AO in the Nerve Fiber Layer (NFL), and after WFS-less AO in the Plexiform Layer (IPL), and Outer Plexiform Layer (OPL). Scale bar: 10 µm.
Fig. 5
Fig. 5 Imaging EGFP labeled microglia with Wavefront Sensor Adaptive Optics (WFS AO). (a) Reflectance imaging in the inner retinal blood vessels. (b) Fluorescence imaging of EGFP labeled microglia. (c) The fluorescence image superimposed in green on the reflectance image in magenta. Scale bar: 20 µm. (d) The measured wavefront RMS during WFS AO without defocus. (e) The wavefront measurements in Zernike decomposition before and after the WFS AO aberration correction.
Fig. 6
Fig. 6 (a) Imaging EGFP labeled microglia within the inner retina of a mouse with Wavefront Sensor based Adaptive Optics (WFS AO) and Wavefront Sensorless Adaptive Optics (WFS-less AO). Fluorescence image with WFS AO aberration correction (left). Fluorescence image with WFS-less AO aberration correction (middle). Fluorescence images before and after WFS-less AO with a ~40 µm FOV (right). Scale bar: 20 µm. (b) The intensity line plot between the red arrows on the WFS AO image and between the blue arrows on the WFS-less AO image.
Fig. 7
Fig. 7 (a) Imaging EGFP labeled microglia within the inner retina of a mouse with Wavefront Sensor based Adaptive Optics (WFS AO) and Wavefront Sensorless Adaptive Optics (WFS-less AO). Fluorescence image after WFS AO (left). Fluorescence image after WFS AO and WFS-less AO aberration correction of residual aberration (middle). Fluorescence image with a smaller FOV of microglia dendrites superimposed in green on the reflectance image of the retinal blood vessels in magenta (right). (b) The Zernike decomposition of the wavefront measured before WFS AO and after both methods of AO. Scale bar: 20 µm.
Fig. 8
Fig. 8 Adaptive Optics Scanning Laser Ophthalmoscopy (AO-SLO) system schematic. The layout is presented in a scale drawing. Abbreviations: L#, lens; F#, filter; BS#, beamsplitter; M, mirror; SM, spherical mirror; DM, deformable mirror; D#, dichroic mirror; Hsc, horizontal resonant scanner; Vsc, vertical scanner; PMT, photomultiplier tube; P (circled in blue) optical planes conjugate with the pupil; SLD, superluminescent diode. Collimated beams are marked as dashed lines and focusing beams are marked as solid lines. The on-axis beams are represented by red lines and scanned beams by green and blue.
Fig. 9
Fig. 9 (a, b) Further mouse photoreceptor imaging with Wavefront Sensor Adaptive Optics (WFS AO) and Wavefront Sensorless Adaptive Optics (WFS-less AO). Images mouse photoreceptor mosaic after WFS AO and WFS-less AO. Scale bar 10 µm. The Zernike decomposition of the wavefront measured before and after each method of AO. The wavefront RMS during WFS-less AO optimization. The image quality improvement during WFS-less AO optimization.

Tables (1)

Tables Icon

Table 1 Key optical parameters of the AO-SLO system components

Equations (2)

Equations on this page are rendered with MathJax. Learn more.

S img = x,y [ I(x,y) ] 2 ,
c= A z.

Metrics