Abstract

We demonstrated that in vivo brain glioma in a mouse model using a continuous-wave terahertz reflection imaging system, as well as the ex vivo fresh brain tissues in mouse model. The tumor regions of in vivo and ex vivo brain tissues can be well distinguished by THz intensity imaging at the frequency of 2.52THz. The THz images with high sensitivity correlated well with magnetic resonance, visual and hematoxylin and eosin stained images. Furthermore, the THz spectral difference between brain gliomas and normal brain tissues were obtained in the 0.6THz to 2.8THz range, where brain gliomas have the higher refractive indices and absorption coefficients, and their differences increase particularly in the high frequency range. These results suggest that THz imaging has great potential as an alternative method for the intraoperative label-free diagnosis of brain glioma in vivo.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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2019 (1)

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

2018 (2)

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

2017 (1)

2016 (3)

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Origin and quantification of differences between normal and tumor tissues observed by terahertz spectroscopy,” Phys. Med. Biol. 61(18), 6808–6820 (2016).
[Crossref] [PubMed]

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Brain tumor imaging of rat fresh tissue using terahertz spectroscopy,” Sci. Rep. 6(1), 30124 (2016).
[Crossref] [PubMed]

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

2014 (3)

S. J. Oh, S. H. Kim, Y. B. Ji, K. Jeong, Y. Park, J. Yang, D. W. Park, S. K. Noh, S. G. Kang, Y. M. Huh, J. H. Son, and J. S. Suh, “Study of freshly excised brain tissues using terahertz imaging,” Biomed. Opt. Express 5(8), 2837–2842 (2014).
[Crossref] [PubMed]

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

2013 (1)

2012 (1)

2011 (3)

C. B. Reid, A. Fitzgerald, G. Reese, R. Goldin, P. Tekkis, P. S. O’Kelly, E. Pickwell-MacPherson, A. P. Gibson, and V. P. Wallace, “Terahertz pulsed imaging of freshly excised human colonic tissues,” Phys. Med. Biol. 56(14), 4333–4353 (2011).
[Crossref] [PubMed]

P. Wesseling, J. M. Kros, and J. W. M. Jeuken, “The pathological diagnosis of diffuse gliomas: towards a smart synthesis of microscopic and molecular information in a multidisciplinary context,” Diagn. Histopathol. 17(11), 486–494 (2011).
[Crossref]

Y. Y. Wang, T. Notake, M. Tang, K. Nawata, H. Ito, and H. Minamide, “Terahertz-wave water concentration and distribution measurement in thin biotissue based on a novel sample preparation,” Phys. Med. Biol. 56(14), 4517–4527 (2011).
[Crossref] [PubMed]

2010 (3)

M. Hefti, H. M. Mehdorn, I. Albert, and L. Dorner, “Fluorescence-guided surgery for malignant glioma: a reviewon aminolevulinic acid induced protoporphyrin IX photodynamic diagnostic in brain tumors,” Curr. Med. Imaging Rev. 6(4), 254–258 (2010).
[Crossref]

M. Jansen, S. Yip, and D. N. Louis, “Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers,” Lancet Neurol. 9(7), 717–726 (2010).
[Crossref] [PubMed]

E. G. Van Meir, C. G. Hadjipanayis, A. D. Norden, H. K. Shu, P. Y. Wen, and J. J. Olson, “Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma,” CA Cancer J. Clin. 60(3), 166–193 (2010).
[Crossref] [PubMed]

2009 (1)

J. H. Son, “Terahertz electromagnetic interactions with biological matter and their applications,” J. Appl. Phys. 105(10), 102033 (2009).
[Crossref]

2008 (1)

K. R. Swanson, G. Chakraborty, C. H. Wang, R. Rockne, H. L. P. Harpold, M. Muzi, T. C. H. Adamsen, K. A. Krohn, and A. M. Spence, “Complementary but distinct roles for MRI and 18F-Fluoromisonidazole PET in the assessment of human glioblastomas,” J. Nucl. Med. 50(1), 36–44 (2008).
[Crossref] [PubMed]

2006 (1)

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

2005 (1)

2003 (1)

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Adamsen, T. C. H.

K. R. Swanson, G. Chakraborty, C. H. Wang, R. Rockne, H. L. P. Harpold, M. Muzi, T. C. H. Adamsen, K. A. Krohn, and A. M. Spence, “Complementary but distinct roles for MRI and 18F-Fluoromisonidazole PET in the assessment of human glioblastomas,” J. Nucl. Med. 50(1), 36–44 (2008).
[Crossref] [PubMed]

Ahn, K. M.

Albert, I.

M. Hefti, H. M. Mehdorn, I. Albert, and L. Dorner, “Fluorescence-guided surgery for malignant glioma: a reviewon aminolevulinic acid induced protoporphyrin IX photodynamic diagnostic in brain tumors,” Curr. Med. Imaging Rev. 6(4), 254–258 (2010).
[Crossref]

Arnone, D. D.

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Bajwa, N.

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

Barnholtz-Sloan, J. S.

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

Bauchet, L.

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

Beshplav, S. I. T.

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Beshplav, S. T.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

Brown, E.

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

Chakraborty, G.

K. R. Swanson, G. Chakraborty, C. H. Wang, R. Rockne, H. L. P. Harpold, M. Muzi, T. C. H. Adamsen, K. A. Krohn, and A. M. Spence, “Complementary but distinct roles for MRI and 18F-Fluoromisonidazole PET in the assessment of human glioblastomas,” J. Nucl. Med. 50(1), 36–44 (2008).
[Crossref] [PubMed]

Chang, J. H.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

Chantra, S.

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

Chen, T.

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

Chen, T. N.

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

Cheon, H.

Cherkasova, O. P.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

Chernomyrdin, N. V.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Cho, S. W.

Choi, H. J.

Choi, Y.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

K. W. Kim, K.-S. Kim, H. Kim, S. H. Lee, J.-H. Park, J.-H. Han, S.-H. Seok, J. Park, Y. Choi, Y. I. Kim, J. K. Han, and J.-H. Son, “Terahertz dynamic imaging of skin drug absorption,” Opt. Express 20(9), 9476–9484 (2012).
[Crossref] [PubMed]

Cole, B. E.

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Davis, F. G.

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

Deltour, I.

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

Deng, S. X.

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

Dolganova, I. N.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Dorner, L.

M. Hefti, H. M. Mehdorn, I. Albert, and L. Dorner, “Fluorescence-guided surgery for malignant glioma: a reviewon aminolevulinic acid induced protoporphyrin IX photodynamic diagnostic in brain tumors,” Curr. Med. Imaging Rev. 6(4), 254–258 (2010).
[Crossref]

Feng, H.

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

Fisher, J. L.

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

Fitzgerald, A.

C. B. Reid, A. Fitzgerald, G. Reese, R. Goldin, P. Tekkis, P. S. O’Kelly, E. Pickwell-MacPherson, A. P. Gibson, and V. P. Wallace, “Terahertz pulsed imaging of freshly excised human colonic tissues,” Phys. Med. Biol. 56(14), 4333–4353 (2011).
[Crossref] [PubMed]

Fukushi, Y.

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Brain tumor imaging of rat fresh tissue using terahertz spectroscopy,” Sci. Rep. 6(1), 30124 (2016).
[Crossref] [PubMed]

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Origin and quantification of differences between normal and tumor tissues observed by terahertz spectroscopy,” Phys. Med. Biol. 61(18), 6808–6820 (2016).
[Crossref] [PubMed]

Garritano, J.

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

Gavdush, A. A.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Gibson, A. P.

C. B. Reid, A. Fitzgerald, G. Reese, R. Goldin, P. Tekkis, P. S. O’Kelly, E. Pickwell-MacPherson, A. P. Gibson, and V. P. Wallace, “Terahertz pulsed imaging of freshly excised human colonic tissues,” Phys. Med. Biol. 56(14), 4333–4353 (2011).
[Crossref] [PubMed]

Goell, J.

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

Goldin, R.

C. B. Reid, A. Fitzgerald, G. Reese, R. Goldin, P. Tekkis, P. S. O’Kelly, E. Pickwell-MacPherson, A. P. Gibson, and V. P. Wallace, “Terahertz pulsed imaging of freshly excised human colonic tissues,” Phys. Med. Biol. 56(14), 4333–4353 (2011).
[Crossref] [PubMed]

Goryaynov, S. A.

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Grundfest, W. S.

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

Haam, S. J.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

Hadjipanayis, C. G.

E. G. Van Meir, C. G. Hadjipanayis, A. D. Norden, H. K. Shu, P. Y. Wen, and J. J. Olson, “Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma,” CA Cancer J. Clin. 60(3), 166–193 (2010).
[Crossref] [PubMed]

Han, J. K.

Han, J.-H.

Harpold, H. L. P.

K. R. Swanson, G. Chakraborty, C. H. Wang, R. Rockne, H. L. P. Harpold, M. Muzi, T. C. H. Adamsen, K. A. Krohn, and A. M. Spence, “Complementary but distinct roles for MRI and 18F-Fluoromisonidazole PET in the assessment of human glioblastomas,” J. Nucl. Med. 50(1), 36–44 (2008).
[Crossref] [PubMed]

Hefti, M.

M. Hefti, H. M. Mehdorn, I. Albert, and L. Dorner, “Fluorescence-guided surgery for malignant glioma: a reviewon aminolevulinic acid induced protoporphyrin IX photodynamic diagnostic in brain tumors,” Curr. Med. Imaging Rev. 6(4), 254–258 (2010).
[Crossref]

Heo, J.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

Hirori, H.

Huh, Y. M.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

S. J. Oh, S. H. Kim, Y. B. Ji, K. Jeong, Y. Park, J. Yang, D. W. Park, S. K. Noh, S. G. Kang, Y. M. Huh, J. H. Son, and J. S. Suh, “Study of freshly excised brain tissues using terahertz imaging,” Biomed. Opt. Express 5(8), 2837–2842 (2014).
[Crossref] [PubMed]

Ito, H.

Y. Y. Wang, T. Notake, M. Tang, K. Nawata, H. Ito, and H. Minamide, “Terahertz-wave water concentration and distribution measurement in thin biotissue based on a novel sample preparation,” Phys. Med. Biol. 56(14), 4517–4527 (2011).
[Crossref] [PubMed]

Itsuji, T.

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Brain tumor imaging of rat fresh tissue using terahertz spectroscopy,” Sci. Rep. 6(1), 30124 (2016).
[Crossref] [PubMed]

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Origin and quantification of differences between normal and tumor tissues observed by terahertz spectroscopy,” Phys. Med. Biol. 61(18), 6808–6820 (2016).
[Crossref] [PubMed]

Jansen, M.

M. Jansen, S. Yip, and D. N. Louis, “Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers,” Lancet Neurol. 9(7), 717–726 (2010).
[Crossref] [PubMed]

Jeong, K.

Jeuken, J. W. M.

P. Wesseling, J. M. Kros, and J. W. M. Jeuken, “The pathological diagnosis of diffuse gliomas: towards a smart synthesis of microscopic and molecular information in a multidisciplinary context,” Diagn. Histopathol. 17(11), 486–494 (2011).
[Crossref]

Ji, Y. B.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

S. J. Oh, S. H. Kim, Y. B. Ji, K. Jeong, Y. Park, J. Yang, D. W. Park, S. K. Noh, S. G. Kang, Y. M. Huh, J. H. Son, and J. S. Suh, “Study of freshly excised brain tissues using terahertz imaging,” Biomed. Opt. Express 5(8), 2837–2842 (2014).
[Crossref] [PubMed]

Joo, C.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

Kang, S. G.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

S. J. Oh, S. H. Kim, Y. B. Ji, K. Jeong, Y. Park, J. Yang, D. W. Park, S. K. Noh, S. G. Kang, Y. M. Huh, J. H. Son, and J. S. Suh, “Study of freshly excised brain tissues using terahertz imaging,” Biomed. Opt. Express 5(8), 2837–2842 (2014).
[Crossref] [PubMed]

Karasik, V. E.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Katyba, G. M.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Kim, H.

Kim, K. W.

Kim, K.-S.

Kim, S. H.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

S. J. Oh, S. H. Kim, Y. B. Ji, K. Jeong, Y. Park, J. Yang, D. W. Park, S. K. Noh, S. G. Kang, Y. M. Huh, J. H. Son, and J. S. Suh, “Study of freshly excised brain tissues using terahertz imaging,” Biomed. Opt. Express 5(8), 2837–2842 (2014).
[Crossref] [PubMed]

Kim, Y. I.

Komandin, G. A.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Kosyrkova, A. V.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

Krohn, K. A.

K. R. Swanson, G. Chakraborty, C. H. Wang, R. Rockne, H. L. P. Harpold, M. Muzi, T. C. H. Adamsen, K. A. Krohn, and A. M. Spence, “Complementary but distinct roles for MRI and 18F-Fluoromisonidazole PET in the assessment of human glioblastomas,” J. Nucl. Med. 50(1), 36–44 (2008).
[Crossref] [PubMed]

Kros, J. M.

P. Wesseling, J. M. Kros, and J. W. M. Jeuken, “The pathological diagnosis of diffuse gliomas: towards a smart synthesis of microscopic and molecular information in a multidisciplinary context,” Diagn. Histopathol. 17(11), 486–494 (2011).
[Crossref]

Kubota, O.

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Origin and quantification of differences between normal and tumor tissues observed by terahertz spectroscopy,” Phys. Med. Biol. 61(18), 6808–6820 (2016).
[Crossref] [PubMed]

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Brain tumor imaging of rat fresh tissue using terahertz spectroscopy,” Sci. Rep. 6(1), 30124 (2016).
[Crossref] [PubMed]

Kucheryavenko, A. S.

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Kurlov, V. N.

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Langer, C. E.

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

Lee, J. H.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

Lee, S.

Lee, S. H.

Li, A.

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

Li, F.

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

Li, Z.

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

Li, Z. R.

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

Linfield, E. H.

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Liu, Q.

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

Louis, D. N.

M. Jansen, S. Yip, and D. N. Louis, “Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers,” Lancet Neurol. 9(7), 717–726 (2010).
[Crossref] [PubMed]

Malakhov, K. M.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Mehdorn, H. M.

M. Hefti, H. M. Mehdorn, I. Albert, and L. Dorner, “Fluorescence-guided surgery for malignant glioma: a reviewon aminolevulinic acid induced protoporphyrin IX photodynamic diagnostic in brain tumors,” Curr. Med. Imaging Rev. 6(4), 254–258 (2010).
[Crossref]

Meinel, T.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Meng, K.

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

Minamide, H.

Y. Y. Wang, T. Notake, M. Tang, K. Nawata, H. Ito, and H. Minamide, “Terahertz-wave water concentration and distribution measurement in thin biotissue based on a novel sample preparation,” Phys. Med. Biol. 56(14), 4517–4527 (2011).
[Crossref] [PubMed]

Musina, G. R.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

Muzi, M.

K. R. Swanson, G. Chakraborty, C. H. Wang, R. Rockne, H. L. P. Harpold, M. Muzi, T. C. H. Adamsen, K. A. Krohn, and A. M. Spence, “Complementary but distinct roles for MRI and 18F-Fluoromisonidazole PET in the assessment of human glioblastomas,” J. Nucl. Med. 50(1), 36–44 (2008).
[Crossref] [PubMed]

Nagai, M.

Nawata, K.

Y. Y. Wang, T. Notake, M. Tang, K. Nawata, H. Ito, and H. Minamide, “Terahertz-wave water concentration and distribution measurement in thin biotissue based on a novel sample preparation,” Phys. Med. Biol. 56(14), 4517–4527 (2011).
[Crossref] [PubMed]

Nikitin, P. V.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

Noh, S. K.

Norden, A. D.

E. G. Van Meir, C. G. Hadjipanayis, A. D. Norden, H. K. Shu, P. Y. Wen, and J. J. Olson, “Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma,” CA Cancer J. Clin. 60(3), 166–193 (2010).
[Crossref] [PubMed]

Notake, T.

Y. Y. Wang, T. Notake, M. Tang, K. Nawata, H. Ito, and H. Minamide, “Terahertz-wave water concentration and distribution measurement in thin biotissue based on a novel sample preparation,” Phys. Med. Biol. 56(14), 4517–4527 (2011).
[Crossref] [PubMed]

Nowroozi, B.

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

O’Kelly, P. S.

C. B. Reid, A. Fitzgerald, G. Reese, R. Goldin, P. Tekkis, P. S. O’Kelly, E. Pickwell-MacPherson, A. P. Gibson, and V. P. Wallace, “Terahertz pulsed imaging of freshly excised human colonic tissues,” Phys. Med. Biol. 56(14), 4333–4353 (2011).
[Crossref] [PubMed]

Oh, S. J.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

S. J. Oh, S. H. Kim, Y. B. Ji, K. Jeong, Y. Park, J. Yang, D. W. Park, S. K. Noh, S. G. Kang, Y. M. Huh, J. H. Son, and J. S. Suh, “Study of freshly excised brain tissues using terahertz imaging,” Biomed. Opt. Express 5(8), 2837–2842 (2014).
[Crossref] [PubMed]

Olson, J. J.

E. G. Van Meir, C. G. Hadjipanayis, A. D. Norden, H. K. Shu, P. Y. Wen, and J. J. Olson, “Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma,” CA Cancer J. Clin. 60(3), 166–193 (2010).
[Crossref] [PubMed]

Ostrom, Q. T.

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

Ouchi, T.

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Origin and quantification of differences between normal and tumor tissues observed by terahertz spectroscopy,” Phys. Med. Biol. 61(18), 6808–6820 (2016).
[Crossref] [PubMed]

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Brain tumor imaging of rat fresh tissue using terahertz spectroscopy,” Sci. Rep. 6(1), 30124 (2016).
[Crossref] [PubMed]

Park, C.

Park, D. W.

Park, J.

Park, J. Y.

Park, J.-H.

Park, Y.

Pekmezci, M.

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

Pepper, M.

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Pichlmeier, U.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Pickwell-MacPherson, E.

C. B. Reid, A. Fitzgerald, G. Reese, R. Goldin, P. Tekkis, P. S. O’Kelly, E. Pickwell-MacPherson, A. P. Gibson, and V. P. Wallace, “Terahertz pulsed imaging of freshly excised human colonic tissues,” Phys. Med. Biol. 56(14), 4333–4353 (2011).
[Crossref] [PubMed]

Potapov, A. A.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Pye, R. J.

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Reese, G.

C. B. Reid, A. Fitzgerald, G. Reese, R. Goldin, P. Tekkis, P. S. O’Kelly, E. Pickwell-MacPherson, A. P. Gibson, and V. P. Wallace, “Terahertz pulsed imaging of freshly excised human colonic tissues,” Phys. Med. Biol. 56(14), 4333–4353 (2011).
[Crossref] [PubMed]

Reid, C. B.

C. B. Reid, A. Fitzgerald, G. Reese, R. Goldin, P. Tekkis, P. S. O’Kelly, E. Pickwell-MacPherson, A. P. Gibson, and V. P. Wallace, “Terahertz pulsed imaging of freshly excised human colonic tissues,” Phys. Med. Biol. 56(14), 4333–4353 (2011).
[Crossref] [PubMed]

Reshetov, I. V.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

Reulen, H. J.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Rockne, R.

K. R. Swanson, G. Chakraborty, C. H. Wang, R. Rockne, H. L. P. Harpold, M. Muzi, T. C. H. Adamsen, K. A. Krohn, and A. M. Spence, “Complementary but distinct roles for MRI and 18F-Fluoromisonidazole PET in the assessment of human glioblastomas,” J. Nucl. Med. 50(1), 36–44 (2008).
[Crossref] [PubMed]

Schwartzbaum, J. A.

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

Selvin, S.

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

Seok, S.-H.

Shu, H. K.

E. G. Van Meir, C. G. Hadjipanayis, A. D. Norden, H. K. Shu, P. Y. Wen, and J. J. Olson, “Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma,” CA Cancer J. Clin. 60(3), 166–193 (2010).
[Crossref] [PubMed]

Sim, Y. C.

Son, H. Y.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

Son, J. H.

Son, J.-H.

Song, S.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

Spektor, I. E.

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Spence, A. M.

K. R. Swanson, G. Chakraborty, C. H. Wang, R. Rockne, H. L. P. Harpold, M. Muzi, T. C. H. Adamsen, K. A. Krohn, and A. M. Spence, “Complementary but distinct roles for MRI and 18F-Fluoromisonidazole PET in the assessment of human glioblastomas,” J. Nucl. Med. 50(1), 36–44 (2008).
[Crossref] [PubMed]

Stummer, W.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Suh, J. S.

Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
[Crossref] [PubMed]

S. J. Oh, S. H. Kim, Y. B. Ji, K. Jeong, Y. Park, J. Yang, D. W. Park, S. K. Noh, S. G. Kang, Y. M. Huh, J. H. Son, and J. S. Suh, “Study of freshly excised brain tissues using terahertz imaging,” Biomed. Opt. Express 5(8), 2837–2842 (2014).
[Crossref] [PubMed]

Sung, S.

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

Swanson, K. R.

K. R. Swanson, G. Chakraborty, C. H. Wang, R. Rockne, H. L. P. Harpold, M. Muzi, T. C. H. Adamsen, K. A. Krohn, and A. M. Spence, “Complementary but distinct roles for MRI and 18F-Fluoromisonidazole PET in the assessment of human glioblastomas,” J. Nucl. Med. 50(1), 36–44 (2008).
[Crossref] [PubMed]

Tanaka, K.

Tang, M.

Y. Y. Wang, T. Notake, M. Tang, K. Nawata, H. Ito, and H. Minamide, “Terahertz-wave water concentration and distribution measurement in thin biotissue based on a novel sample preparation,” Phys. Med. Biol. 56(14), 4517–4527 (2011).
[Crossref] [PubMed]

Taylor, Z. D.

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
[Crossref] [PubMed]

Tekkis, P.

C. B. Reid, A. Fitzgerald, G. Reese, R. Goldin, P. Tekkis, P. S. O’Kelly, E. Pickwell-MacPherson, A. P. Gibson, and V. P. Wallace, “Terahertz pulsed imaging of freshly excised human colonic tissues,” Phys. Med. Biol. 56(14), 4333–4353 (2011).
[Crossref] [PubMed]

Tuchin, V. V.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Turner, M. C.

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

Van Meir, E. G.

E. G. Van Meir, C. G. Hadjipanayis, A. D. Norden, H. K. Shu, P. Y. Wen, and J. J. Olson, “Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma,” CA Cancer J. Clin. 60(3), 166–193 (2010).
[Crossref] [PubMed]

Wallace, V. P.

C. B. Reid, A. Fitzgerald, G. Reese, R. Goldin, P. Tekkis, P. S. O’Kelly, E. Pickwell-MacPherson, A. P. Gibson, and V. P. Wallace, “Terahertz pulsed imaging of freshly excised human colonic tissues,” Phys. Med. Biol. 56(14), 4333–4353 (2011).
[Crossref] [PubMed]

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Walsh, K. M.

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

Wang, C. H.

K. R. Swanson, G. Chakraborty, C. H. Wang, R. Rockne, H. L. P. Harpold, M. Muzi, T. C. H. Adamsen, K. A. Krohn, and A. M. Spence, “Complementary but distinct roles for MRI and 18F-Fluoromisonidazole PET in the assessment of human glioblastomas,” J. Nucl. Med. 50(1), 36–44 (2008).
[Crossref] [PubMed]

Wang, Y. Y.

Y. Y. Wang, T. Notake, M. Tang, K. Nawata, H. Ito, and H. Minamide, “Terahertz-wave water concentration and distribution measurement in thin biotissue based on a novel sample preparation,” Phys. Med. Biol. 56(14), 4517–4527 (2011).
[Crossref] [PubMed]

Wen, P. Y.

E. G. Van Meir, C. G. Hadjipanayis, A. D. Norden, H. K. Shu, P. Y. Wen, and J. J. Olson, “Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma,” CA Cancer J. Clin. 60(3), 166–193 (2010).
[Crossref] [PubMed]

Wesseling, P.

P. Wesseling, J. M. Kros, and J. W. M. Jeuken, “The pathological diagnosis of diffuse gliomas: towards a smart synthesis of microscopic and molecular information in a multidisciplinary context,” Diagn. Histopathol. 17(11), 486–494 (2011).
[Crossref]

Wiestler, O. D.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Woodward, R. M.

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Wrensch, M. R.

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
[Crossref] [PubMed]

Yamaguchi, S.

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Origin and quantification of differences between normal and tumor tissues observed by terahertz spectroscopy,” Phys. Med. Biol. 61(18), 6808–6820 (2016).
[Crossref] [PubMed]

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Brain tumor imaging of rat fresh tissue using terahertz spectroscopy,” Sci. Rep. 6(1), 30124 (2016).
[Crossref] [PubMed]

Yamamoto, S.

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Brain tumor imaging of rat fresh tissue using terahertz spectroscopy,” Sci. Rep. 6(1), 30124 (2016).
[Crossref] [PubMed]

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Origin and quantification of differences between normal and tumor tissues observed by terahertz spectroscopy,” Phys. Med. Biol. 61(18), 6808–6820 (2016).
[Crossref] [PubMed]

Yang, J.

Yip, S.

M. Jansen, S. Yip, and D. N. Louis, “Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers,” Lancet Neurol. 9(7), 717–726 (2010).
[Crossref] [PubMed]

Yurchenko, S. O.

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Zanella, F.

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Zaytsev, K. I.

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
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Zaytseva, K. I.

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Zhao, J. H.

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

Zhong, S. C.

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

Zhu, L. G.

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

Biomed. Opt. Express (3)

CA Cancer J. Clin. (1)

E. G. Van Meir, C. G. Hadjipanayis, A. D. Norden, H. K. Shu, P. Y. Wen, and J. J. Olson, “Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma,” CA Cancer J. Clin. 60(3), 166–193 (2010).
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Curr. Med. Imaging Rev. (1)

M. Hefti, H. M. Mehdorn, I. Albert, and L. Dorner, “Fluorescence-guided surgery for malignant glioma: a reviewon aminolevulinic acid induced protoporphyrin IX photodynamic diagnostic in brain tumors,” Curr. Med. Imaging Rev. 6(4), 254–258 (2010).
[Crossref]

Diagn. Histopathol. (1)

P. Wesseling, J. M. Kros, and J. W. M. Jeuken, “The pathological diagnosis of diffuse gliomas: towards a smart synthesis of microscopic and molecular information in a multidisciplinary context,” Diagn. Histopathol. 17(11), 486–494 (2011).
[Crossref]

IEEE Trans. Terahertz Sci. Technol. (1)

S. Sung, S. Selvin, N. Bajwa, S. Chantra, B. Nowroozi, J. Garritano, J. Goell, A. Li, S. X. Deng, E. Brown, W. S. Grundfest, and Z. D. Taylor, “THz Imaging System for in vivo human cornea,” IEEE Trans. Terahertz Sci. Technol. 8(1), 27–37 (2018).
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J. Appl. Phys. (1)

J. H. Son, “Terahertz electromagnetic interactions with biological matter and their applications,” J. Appl. Phys. 105(10), 102033 (2009).
[Crossref]

J. Biomed. Opt. (2)

K. Meng, T. N. Chen, T. Chen, L. G. Zhu, Q. Liu, Z. Li, F. Li, S. C. Zhong, Z. R. Li, H. Feng, and J. H. Zhao, “Terahertz pulsed spectroscopy of paraffin-embedded brain glioma,” J. Biomed. Opt. 19(7), 077001 (2014).
[Crossref] [PubMed]

A. A. Gavdush, N. V. Chernomyrdin, K. M. Malakhov, S. T. Beshplav, I. N. Dolganova, A. V. Kosyrkova, P. V. Nikitin, G. R. Musina, G. M. Katyba, I. V. Reshetov, O. P. Cherkasova, G. A. Komandin, V. E. Karasik, A. A. Potapov, V. V. Tuchin, and K. I. Zaytsev, “Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis,” J. Biomed. Opt. 24(2), 1–5 (2019).
[Crossref] [PubMed]

J. Invest. Dermatol. (1)

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

J. Nucl. Med. (1)

K. R. Swanson, G. Chakraborty, C. H. Wang, R. Rockne, H. L. P. Harpold, M. Muzi, T. C. H. Adamsen, K. A. Krohn, and A. M. Spence, “Complementary but distinct roles for MRI and 18F-Fluoromisonidazole PET in the assessment of human glioblastomas,” J. Nucl. Med. 50(1), 36–44 (2008).
[Crossref] [PubMed]

Lancet Neurol. (1)

M. Jansen, S. Yip, and D. N. Louis, “Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers,” Lancet Neurol. 9(7), 717–726 (2010).
[Crossref] [PubMed]

Lancet Oncol. (1)

W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen, and ALA-Glioma Study Group, “Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial,” Lancet Oncol. 7(5), 392–401 (2006).
[Crossref] [PubMed]

Neuro-oncol. (1)

Q. T. Ostrom, L. Bauchet, F. G. Davis, I. Deltour, J. L. Fisher, C. E. Langer, M. Pekmezci, J. A. Schwartzbaum, M. C. Turner, K. M. Walsh, M. R. Wrensch, and J. S. Barnholtz-Sloan, “The epidemiology of glioma in adults: a “state of the science” review,” Neuro-oncol. 16(7), 896–913 (2014).
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Opt. Express (2)

Phys. Med. Biol. (3)

Y. Y. Wang, T. Notake, M. Tang, K. Nawata, H. Ito, and H. Minamide, “Terahertz-wave water concentration and distribution measurement in thin biotissue based on a novel sample preparation,” Phys. Med. Biol. 56(14), 4517–4527 (2011).
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S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Origin and quantification of differences between normal and tumor tissues observed by terahertz spectroscopy,” Phys. Med. Biol. 61(18), 6808–6820 (2016).
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C. B. Reid, A. Fitzgerald, G. Reese, R. Goldin, P. Tekkis, P. S. O’Kelly, E. Pickwell-MacPherson, A. P. Gibson, and V. P. Wallace, “Terahertz pulsed imaging of freshly excised human colonic tissues,” Phys. Med. Biol. 56(14), 4333–4353 (2011).
[Crossref] [PubMed]

Proc. SPIE (1)

N. V. Chernomyrdin, A. A. Gavdush, S. I. T. Beshplav, K. M. Malakhov, A. S. Kucheryavenko, G. M. Katyba, I. N. Dolganova, S. A. Goryaynov, V. E. Karasik, I. E. Spektor, V. N. Kurlov, S. O. Yurchenko, G. A. Komandin, A. A. Potapov, V. V. Tuchin, and K. I. Zaytseva, “In vitro terahertz spectroscopy of gelatin-embedded human brain tumors a pilot study,” Proc. SPIE 10716, 107160S (2018).

Sci. Rep. (2)

S. Yamaguchi, Y. Fukushi, O. Kubota, T. Itsuji, T. Ouchi, and S. Yamamoto, “Brain tumor imaging of rat fresh tissue using terahertz spectroscopy,” Sci. Rep. 6(1), 30124 (2016).
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Y. B. Ji, S. J. Oh, S. G. Kang, J. Heo, S. H. Kim, Y. Choi, S. Song, H. Y. Son, S. H. Kim, J. H. Lee, S. J. Haam, Y. M. Huh, J. H. Chang, C. Joo, and J. S. Suh, “Terahertz reflectometry imaging for low and high grade gliomas,” Sci. Rep. 6(1), 36040 (2016).
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Other (2)

R. R. Edelman, J. R. Hesselink, and M. B. Zlatkin, Clinical Magnetic Resonance Imaging, Chap. 1 (Saunders, 1996).

S. J. Oh, Y. M. Huh, S. H. Kim, J. Yang, K. Jeong, Y. Park, C. Kang, J. H. Son, and J. S. Suh, “Terahertz pulse imaging of fresh brain tumor,” in 36th Int. Conf. on Infrared, Millimeter and Terahertz Waves (IRMMWTHz) (2011).
[Crossref]

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Figures (5)

Fig. 1
Fig. 1 Continuous-wave terahertz reflection imaging system.
Fig. 2
Fig. 2 (a) MR, (b) visual of in vivo, (c) THz reflection, (d) visual of fresh excised and (e)H&E-stained images of whole brain images with (Nos. 1–3) and without (No. 4) tumors.
Fig. 3
Fig. 3 THz reflectivity on the (a) horizontal, (b) vertical lines of Fig. 2(c).
Fig. 4
Fig. 4 (a) MR, (b) Visual, (c) H&E-stained and (d) terahertz reflection images of fresh excised brain tissues without (No. 5) and with (Nos. 6-8) tumors.
Fig. 5
Fig. 5 (a) The THz-TDS signal, (b) the power, (c) the refractive index, and (d) the absorption coefficient of the freshly excised brain tissue samples. The insets of (c) and (d) show the difference of the refractive index and the absorption coefficient between tumor and normal tissue, respectively.

Tables (1)

Tables Icon

Table 1 Tumor Sizes of MR, Histological and TR Images