Abstract

Active Er-laser drug delivery under the nail plate using a drug-impregnated gel containing liquid methylene blue clusters is demonstrated for the first time. The effect of the agar-agar concentration in the gel and the gel plate thickness on the number of Er:YLF-laser pulses required for formation of a through microhole in the gel and in the nail plate with subsequent active drug delivery is discussed. The influence of the laser pulse energy, the gel plate thickness, and the external pressure applied to the gel on the rate of delivery of methylene blue under the nail plate through a single microhole in it is investigated. It is shown that with a laser pulse energy of 4.0 ± 0.1 mJ, the delivery rate can reach 0.024 ± 0.004 mg/pulse.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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    [Crossref] [PubMed]

2018 (1)

A. V. Belikov, A. V. Skrypnik, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Er: YLF-laser microperforation of the nail plate for drug delivery,” Proc. SPIE 10716, 107160X (2018).

2017 (1)

A. V. Belikov, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Microperforation of the human nail plate by radiation of erbium lasers,” Front Optoelectron. 10(3), 299–307 (2017).
[Crossref]

2016 (1)

M. T. Tsai, T. Y. Tsai, S. C. Shen, C. Y. Ng, Y. J. Lee, J. D. Lee, and C. H. Yang, “Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography,” Sensors (Basel) 16(12), 2111 (2016).
[Crossref] [PubMed]

2015 (2)

A. V. Belikov, A. V. Skrypnik, K. V. Shatilova, and V. V. Tuchin, “Multi-beam laser-induced hydrodynamic shock waves used for delivery of microparticles and liquids in skin,” Lasers Surg. Med. 47(9), 723–736 (2015).
[Crossref] [PubMed]

S. E. Katorkin and M. V. Nasyrov, “The use of photodynamic therapy in local treatment and preoperative preparation of trophic ulcers of venous etiology,” Surgery News 23, 2 (2015).

2014 (3)

E. H. Lim, H. R. Kim, Y. O. Park, Y. Lee, Y. J. Seo, C. D. Kim, J. H. Lee, and M. Im, “Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream,” J. Am. Acad. Dermatol. 70(5), 918–923 (2014).
[Crossref] [PubMed]

M. V. Saner, A. D. Kulkarni, and C. V. Pardeshi, “Insights into drug delivery across the nail plate barrier,” J. Drug Target. 22(9), 769–789 (2014).
[Crossref] [PubMed]

M. V. Saner, A. D. Kulkarni, and C. V. Pardeshi, “Insights into drug delivery across the nail plate barrier,” J. Drug Target. 22(9), 769–789 (2014).
[Crossref] [PubMed]

2013 (3)

M. J. Myers, J. A. Myers, F. Roth, B. Guo, C. R. Hardy, S. Myers, A. Carrabba, C. B. S. Trywick, J. R. Griswold, and A. Mazzochi, “Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm,” Proc. of SPIE 8565, 85650W1 (2013).

O. O. D. Morais, I. M. C. Costa, C. M. Gomes, D. H. Shinzato, G. M. C. Ayres, and R. M. Cardoso, “The use of the Er:YAG 2940nm laser associated with amorolfine lacquer in the treatment of onychomycosis,” An. Bras. Dermatol. 88(5), 847–849 (2013).
[PubMed]

P. A. Zelezny and S. E. Akimova, “A comparative review of dental materials used in the biological treatment of chronic forms of pulpitis in teeth with unformed roots,” Endodontics today 2(1), 3–6 (2013).

2012 (1)

2011 (2)

W. R. Lee, S. C. Shen, S. A. Al-Suwayeh, H. H. Yang, C. Y. Yuan, and J. Y. Fang, “Laser-assisted topical drug delivery by using a low-fluence fractional laser: imiquimod and macromolecules,” J. Control. Release 153(3), 240–248 (2011).
[Crossref] [PubMed]

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

2010 (5)

M. Haedersdal, F. H. Sakamoto, W. A. Farinelli, A. G. Doukas, J. Tam, and R. R. Anderson, “Fractional CO(2) laser-assisted drug delivery,” Lasers Surg. Med. 42(2), 113–122 (2010).
[Crossref] [PubMed]

I. Vejnovic, L. Simmler, and G. Betz, “Investigation of different formulations for drug delivery through the nail plate,” Int. J. Pharm. 386(1-2), 185–194 (2010).
[PubMed]

R. Elkeeb, A. AliKhan, L. Elkeeb, X. Hui, and H. I. Maibach, “Transungual drug delivery: current status,” Int. J. Pharm. 384(1-2), 1–8 (2010).
[Crossref] [PubMed]

J. Kozarev, “Novel laser therapy in treatment of onychomycosis,” Journal of the Laser and Health Academy 2010(1), 1–8 (2010).

T. H. Han and J. J. Yoh, “A laser based reusable microjet injector for transdermal drug delivery,” J. Appl. Phys. 107(10), 103110 (2010).
[Crossref]

2008 (3)

V. M. Bondarenko, G. N. Konovalova, E. V. Nikolayeva, A. N. Kuzikov, and E. V. Likhacheva, “Photodynamic effect of metal complexes of chlorin E6 derivatives on conditionally pathogenic bacteria using super-bright “cold” white light-emitting diodes,” Laser Medicine 12(2), 26–30 (2008).

A. P. Bobrov and A. N. Badmaeva, “The use of photoditazin in the treatment of inflammatory periodontal diseases caused by dentures,” Russian Biotherapeutic J.  7, 4 (2008).

S. Murdan, “Enhancing the nail permeability of topically applied drugs,” Expert Opin. Drug Deliv. 5(11), 1267–1282 (2008).
[Crossref] [PubMed]

2007 (1)

S. Narasimha Murthy, D. E. Wiskirchen, and C. P. Bowers, “Iontophoretic drug delivery across human nail,” J. Pharm. Sci. 96(2), 305–311 (2007).
[Crossref] [PubMed]

2004 (1)

P. M. Sinha, G. Valco, S. Sharma, X. Liu, and M. Ferrari, “Nanoengineered device for drug delivery application,” Nanotechnology 15(10), S585–S589 (2004).
[Crossref]

2002 (1)

S. Murdan, “Drug delivery to the nail following topical application,” Int. J. Pharm. 236(1-2), 1–26 (2002).
[Crossref] [PubMed]

2000 (1)

C. Peter, D. Hongwan, A. Küpfer, and B. H. Lauterburg, “Pharmacokinetics and organ distribution of intravenous and oral methylene blue,” Eur. J. Clin. Pharmacol. 56(3), 247–250 (2000).
[Crossref] [PubMed]

1997 (2)

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

1992 (1)

P. R. Cohen and R. K. Scher, “Geriatric nail disorders: diagnosis and treatment,” J. Am. Acad. Dermatol. 26(4), 521–531 (1992).
[Crossref] [PubMed]

1985 (1)

R. M. Adams, “Effects of mechanical trauma on nails,” Am. J. Ind. Med. 8(4-5), 273–280 (1985).
[Crossref] [PubMed]

Adams, R. M.

R. M. Adams, “Effects of mechanical trauma on nails,” Am. J. Ind. Med. 8(4-5), 273–280 (1985).
[Crossref] [PubMed]

Akimova, S. E.

P. A. Zelezny and S. E. Akimova, “A comparative review of dental materials used in the biological treatment of chronic forms of pulpitis in teeth with unformed roots,” Endodontics today 2(1), 3–6 (2013).

AliKhan, A.

R. Elkeeb, A. AliKhan, L. Elkeeb, X. Hui, and H. I. Maibach, “Transungual drug delivery: current status,” Int. J. Pharm. 384(1-2), 1–8 (2010).
[Crossref] [PubMed]

Al-Suwayeh, S. A.

W. R. Lee, S. C. Shen, S. A. Al-Suwayeh, H. H. Yang, C. Y. Yuan, and J. Y. Fang, “Laser-assisted topical drug delivery by using a low-fluence fractional laser: imiquimod and macromolecules,” J. Control. Release 153(3), 240–248 (2011).
[Crossref] [PubMed]

Anderson, R. R.

M. Haedersdal, F. H. Sakamoto, W. A. Farinelli, A. G. Doukas, J. Tam, and R. R. Anderson, “Fractional CO(2) laser-assisted drug delivery,” Lasers Surg. Med. 42(2), 113–122 (2010).
[Crossref] [PubMed]

Ayres, G. M. C.

O. O. D. Morais, I. M. C. Costa, C. M. Gomes, D. H. Shinzato, G. M. C. Ayres, and R. M. Cardoso, “The use of the Er:YAG 2940nm laser associated with amorolfine lacquer in the treatment of onychomycosis,” An. Bras. Dermatol. 88(5), 847–849 (2013).
[PubMed]

Badmaeva, A. N.

A. P. Bobrov and A. N. Badmaeva, “The use of photoditazin in the treatment of inflammatory periodontal diseases caused by dentures,” Russian Biotherapeutic J.  7, 4 (2008).

Bashkatov, A. N.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Belikov, A. V.

A. V. Belikov, A. V. Skrypnik, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Er: YLF-laser microperforation of the nail plate for drug delivery,” Proc. SPIE 10716, 107160X (2018).

A. V. Belikov, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Microperforation of the human nail plate by radiation of erbium lasers,” Front Optoelectron. 10(3), 299–307 (2017).
[Crossref]

A. V. Belikov, A. V. Skrypnik, K. V. Shatilova, and V. V. Tuchin, “Multi-beam laser-induced hydrodynamic shock waves used for delivery of microparticles and liquids in skin,” Lasers Surg. Med. 47(9), 723–736 (2015).
[Crossref] [PubMed]

Betz, G.

I. Vejnovic, L. Simmler, and G. Betz, “Investigation of different formulations for drug delivery through the nail plate,” Int. J. Pharm. 386(1-2), 185–194 (2010).
[PubMed]

Bobrov, A. P.

A. P. Bobrov and A. N. Badmaeva, “The use of photoditazin in the treatment of inflammatory periodontal diseases caused by dentures,” Russian Biotherapeutic J.  7, 4 (2008).

Bondarenko, V. M.

V. M. Bondarenko, G. N. Konovalova, E. V. Nikolayeva, A. N. Kuzikov, and E. V. Likhacheva, “Photodynamic effect of metal complexes of chlorin E6 derivatives on conditionally pathogenic bacteria using super-bright “cold” white light-emitting diodes,” Laser Medicine 12(2), 26–30 (2008).

Bowers, C. P.

S. Narasimha Murthy, D. E. Wiskirchen, and C. P. Bowers, “Iontophoretic drug delivery across human nail,” J. Pharm. Sci. 96(2), 305–311 (2007).
[Crossref] [PubMed]

Cardoso, R. M.

O. O. D. Morais, I. M. C. Costa, C. M. Gomes, D. H. Shinzato, G. M. C. Ayres, and R. M. Cardoso, “The use of the Er:YAG 2940nm laser associated with amorolfine lacquer in the treatment of onychomycosis,” An. Bras. Dermatol. 88(5), 847–849 (2013).
[PubMed]

Carrabba, A.

M. J. Myers, J. A. Myers, F. Roth, B. Guo, C. R. Hardy, S. Myers, A. Carrabba, C. B. S. Trywick, J. R. Griswold, and A. Mazzochi, “Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm,” Proc. of SPIE 8565, 85650W1 (2013).

Carrasco, W. A.

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

Cheung, E.

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

Cho, S.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Cohen, P. R.

P. R. Cohen and R. K. Scher, “Geriatric nail disorders: diagnosis and treatment,” J. Am. Acad. Dermatol. 26(4), 521–531 (1992).
[Crossref] [PubMed]

Costa, I. M. C.

O. O. D. Morais, I. M. C. Costa, C. M. Gomes, D. H. Shinzato, G. M. C. Ayres, and R. M. Cardoso, “The use of the Er:YAG 2940nm laser associated with amorolfine lacquer in the treatment of onychomycosis,” An. Bras. Dermatol. 88(5), 847–849 (2013).
[PubMed]

Critelli, M.

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

Da Silva, L. B.

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

Doukas, A. G.

M. Haedersdal, F. H. Sakamoto, W. A. Farinelli, A. G. Doukas, J. Tam, and R. R. Anderson, “Fractional CO(2) laser-assisted drug delivery,” Lasers Surg. Med. 42(2), 113–122 (2010).
[Crossref] [PubMed]

Elkeeb, L.

R. Elkeeb, A. AliKhan, L. Elkeeb, X. Hui, and H. I. Maibach, “Transungual drug delivery: current status,” Int. J. Pharm. 384(1-2), 1–8 (2010).
[Crossref] [PubMed]

Elkeeb, R.

R. Elkeeb, A. AliKhan, L. Elkeeb, X. Hui, and H. I. Maibach, “Transungual drug delivery: current status,” Int. J. Pharm. 384(1-2), 1–8 (2010).
[Crossref] [PubMed]

Eum, H.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Fang, J. Y.

W. R. Lee, S. C. Shen, S. A. Al-Suwayeh, H. H. Yang, C. Y. Yuan, and J. Y. Fang, “Laser-assisted topical drug delivery by using a low-fluence fractional laser: imiquimod and macromolecules,” J. Control. Release 153(3), 240–248 (2011).
[Crossref] [PubMed]

Farinelli, W. A.

M. Haedersdal, F. H. Sakamoto, W. A. Farinelli, A. G. Doukas, J. Tam, and R. R. Anderson, “Fractional CO(2) laser-assisted drug delivery,” Lasers Surg. Med. 42(2), 113–122 (2010).
[Crossref] [PubMed]

Ferrari, M.

P. M. Sinha, G. Valco, S. Sharma, X. Liu, and M. Ferrari, “Nanoengineered device for drug delivery application,” Nanotechnology 15(10), S585–S589 (2004).
[Crossref]

Genina, E. A.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Gomes, C. M.

O. O. D. Morais, I. M. C. Costa, C. M. Gomes, D. H. Shinzato, G. M. C. Ayres, and R. M. Cardoso, “The use of the Er:YAG 2940nm laser associated with amorolfine lacquer in the treatment of onychomycosis,” An. Bras. Dermatol. 88(5), 847–849 (2013).
[PubMed]

Griswold, J. R.

M. J. Myers, J. A. Myers, F. Roth, B. Guo, C. R. Hardy, S. Myers, A. Carrabba, C. B. S. Trywick, J. R. Griswold, and A. Mazzochi, “Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm,” Proc. of SPIE 8565, 85650W1 (2013).

Guo, B.

M. J. Myers, J. A. Myers, F. Roth, B. Guo, C. R. Hardy, S. Myers, A. Carrabba, C. B. S. Trywick, J. R. Griswold, and A. Mazzochi, “Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm,” Proc. of SPIE 8565, 85650W1 (2013).

Haedersdal, M.

M. Haedersdal, F. H. Sakamoto, W. A. Farinelli, A. G. Doukas, J. Tam, and R. R. Anderson, “Fractional CO(2) laser-assisted drug delivery,” Lasers Surg. Med. 42(2), 113–122 (2010).
[Crossref] [PubMed]

Han, T. H.

T. H. Han and J. J. Yoh, “A laser based reusable microjet injector for transdermal drug delivery,” J. Appl. Phys. 107(10), 103110 (2010).
[Crossref]

Hardy, C. R.

M. J. Myers, J. A. Myers, F. Roth, B. Guo, C. R. Hardy, S. Myers, A. Carrabba, C. B. S. Trywick, J. R. Griswold, and A. Mazzochi, “Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm,” Proc. of SPIE 8565, 85650W1 (2013).

Hongwan, D.

C. Peter, D. Hongwan, A. Küpfer, and B. H. Lauterburg, “Pharmacokinetics and organ distribution of intravenous and oral methylene blue,” Eur. J. Clin. Pharmacol. 56(3), 247–250 (2000).
[Crossref] [PubMed]

Hui, X.

R. Elkeeb, A. AliKhan, L. Elkeeb, X. Hui, and H. I. Maibach, “Transungual drug delivery: current status,” Int. J. Pharm. 384(1-2), 1–8 (2010).
[Crossref] [PubMed]

Im, M.

E. H. Lim, H. R. Kim, Y. O. Park, Y. Lee, Y. J. Seo, C. D. Kim, J. H. Lee, and M. Im, “Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream,” J. Am. Acad. Dermatol. 70(5), 918–923 (2014).
[Crossref] [PubMed]

Jang, H. J.

Katorkin, S. E.

S. E. Katorkin and M. V. Nasyrov, “The use of photodynamic therapy in local treatment and preoperative preparation of trophic ulcers of venous etiology,” Surgery News 23, 2 (2015).

Kim, C. D.

E. H. Lim, H. R. Kim, Y. O. Park, Y. Lee, Y. J. Seo, C. D. Kim, J. H. Lee, and M. Im, “Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream,” J. Am. Acad. Dermatol. 70(5), 918–923 (2014).
[Crossref] [PubMed]

Kim, D.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Kim, H. R.

E. H. Lim, H. R. Kim, Y. O. Park, Y. Lee, Y. J. Seo, C. D. Kim, J. H. Lee, and M. Im, “Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream,” J. Am. Acad. Dermatol. 70(5), 918–923 (2014).
[Crossref] [PubMed]

Kim, M.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Kochubey, V. I.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Konovalova, G. N.

V. M. Bondarenko, G. N. Konovalova, E. V. Nikolayeva, A. N. Kuzikov, and E. V. Likhacheva, “Photodynamic effect of metal complexes of chlorin E6 derivatives on conditionally pathogenic bacteria using super-bright “cold” white light-emitting diodes,” Laser Medicine 12(2), 26–30 (2008).

Kozarev, J.

J. Kozarev, “Novel laser therapy in treatment of onychomycosis,” Journal of the Laser and Health Academy 2010(1), 1–8 (2010).

Ku, Y.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Kulkarni, A. D.

M. V. Saner, A. D. Kulkarni, and C. V. Pardeshi, “Insights into drug delivery across the nail plate barrier,” J. Drug Target. 22(9), 769–789 (2014).
[Crossref] [PubMed]

M. V. Saner, A. D. Kulkarni, and C. V. Pardeshi, “Insights into drug delivery across the nail plate barrier,” J. Drug Target. 22(9), 769–789 (2014).
[Crossref] [PubMed]

Küpfer, A.

C. Peter, D. Hongwan, A. Küpfer, and B. H. Lauterburg, “Pharmacokinetics and organ distribution of intravenous and oral methylene blue,” Eur. J. Clin. Pharmacol. 56(3), 247–250 (2000).
[Crossref] [PubMed]

Kuzikov, A. N.

V. M. Bondarenko, G. N. Konovalova, E. V. Nikolayeva, A. N. Kuzikov, and E. V. Likhacheva, “Photodynamic effect of metal complexes of chlorin E6 derivatives on conditionally pathogenic bacteria using super-bright “cold” white light-emitting diodes,” Laser Medicine 12(2), 26–30 (2008).

Lauterburg, B. H.

C. Peter, D. Hongwan, A. Küpfer, and B. H. Lauterburg, “Pharmacokinetics and organ distribution of intravenous and oral methylene blue,” Eur. J. Clin. Pharmacol. 56(3), 247–250 (2000).
[Crossref] [PubMed]

Lee, J. D.

M. T. Tsai, T. Y. Tsai, S. C. Shen, C. Y. Ng, Y. J. Lee, J. D. Lee, and C. H. Yang, “Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography,” Sensors (Basel) 16(12), 2111 (2016).
[Crossref] [PubMed]

Lee, J. H.

E. H. Lim, H. R. Kim, Y. O. Park, Y. Lee, Y. J. Seo, C. D. Kim, J. H. Lee, and M. Im, “Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream,” J. Am. Acad. Dermatol. 70(5), 918–923 (2014).
[Crossref] [PubMed]

Lee, W. R.

W. R. Lee, S. C. Shen, S. A. Al-Suwayeh, H. H. Yang, C. Y. Yuan, and J. Y. Fang, “Laser-assisted topical drug delivery by using a low-fluence fractional laser: imiquimod and macromolecules,” J. Control. Release 153(3), 240–248 (2011).
[Crossref] [PubMed]

Lee, Y.

E. H. Lim, H. R. Kim, Y. O. Park, Y. Lee, Y. J. Seo, C. D. Kim, J. H. Lee, and M. Im, “Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream,” J. Am. Acad. Dermatol. 70(5), 918–923 (2014).
[Crossref] [PubMed]

Lee, Y. J.

M. T. Tsai, T. Y. Tsai, S. C. Shen, C. Y. Ng, Y. J. Lee, J. D. Lee, and C. H. Yang, “Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography,” Sensors (Basel) 16(12), 2111 (2016).
[Crossref] [PubMed]

Likhacheva, E. V.

V. M. Bondarenko, G. N. Konovalova, E. V. Nikolayeva, A. N. Kuzikov, and E. V. Likhacheva, “Photodynamic effect of metal complexes of chlorin E6 derivatives on conditionally pathogenic bacteria using super-bright “cold” white light-emitting diodes,” Laser Medicine 12(2), 26–30 (2008).

Lim, E. H.

E. H. Lim, H. R. Kim, Y. O. Park, Y. Lee, Y. J. Seo, C. D. Kim, J. H. Lee, and M. Im, “Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream,” J. Am. Acad. Dermatol. 70(5), 918–923 (2014).
[Crossref] [PubMed]

Liu, X.

P. M. Sinha, G. Valco, S. Sharma, X. Liu, and M. Ferrari, “Nanoengineered device for drug delivery application,” Nanotechnology 15(10), S585–S589 (2004).
[Crossref]

Lychagov, V. V.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Maibach, H. I.

R. Elkeeb, A. AliKhan, L. Elkeeb, X. Hui, and H. I. Maibach, “Transungual drug delivery: current status,” Int. J. Pharm. 384(1-2), 1–8 (2010).
[Crossref] [PubMed]

Mazzochi, A.

M. J. Myers, J. A. Myers, F. Roth, B. Guo, C. R. Hardy, S. Myers, A. Carrabba, C. B. S. Trywick, J. R. Griswold, and A. Mazzochi, “Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm,” Proc. of SPIE 8565, 85650W1 (2013).

McCullough, J. L.

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

Miller, D. R.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Morais, O. O. D.

O. O. D. Morais, I. M. C. Costa, C. M. Gomes, D. H. Shinzato, G. M. C. Ayres, and R. M. Cardoso, “The use of the Er:YAG 2940nm laser associated with amorolfine lacquer in the treatment of onychomycosis,” An. Bras. Dermatol. 88(5), 847–849 (2013).
[PubMed]

Murdan, S.

S. Murdan, “Enhancing the nail permeability of topically applied drugs,” Expert Opin. Drug Deliv. 5(11), 1267–1282 (2008).
[Crossref] [PubMed]

S. Murdan, “Drug delivery to the nail following topical application,” Int. J. Pharm. 236(1-2), 1–26 (2002).
[Crossref] [PubMed]

Myers, J. A.

M. J. Myers, J. A. Myers, F. Roth, B. Guo, C. R. Hardy, S. Myers, A. Carrabba, C. B. S. Trywick, J. R. Griswold, and A. Mazzochi, “Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm,” Proc. of SPIE 8565, 85650W1 (2013).

Myers, M. J.

M. J. Myers, J. A. Myers, F. Roth, B. Guo, C. R. Hardy, S. Myers, A. Carrabba, C. B. S. Trywick, J. R. Griswold, and A. Mazzochi, “Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm,” Proc. of SPIE 8565, 85650W1 (2013).

Myers, S.

M. J. Myers, J. A. Myers, F. Roth, B. Guo, C. R. Hardy, S. Myers, A. Carrabba, C. B. S. Trywick, J. R. Griswold, and A. Mazzochi, “Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm,” Proc. of SPIE 8565, 85650W1 (2013).

Narasimha Murthy, S.

S. Narasimha Murthy, D. E. Wiskirchen, and C. P. Bowers, “Iontophoretic drug delivery across human nail,” J. Pharm. Sci. 96(2), 305–311 (2007).
[Crossref] [PubMed]

Nasyrov, M. V.

S. E. Katorkin and M. V. Nasyrov, “The use of photodynamic therapy in local treatment and preoperative preparation of trophic ulcers of venous etiology,” Surgery News 23, 2 (2015).

Neev, J.

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

Nelson, J. S.

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

Ng, C. Y.

M. T. Tsai, T. Y. Tsai, S. C. Shen, C. Y. Ng, Y. J. Lee, J. D. Lee, and C. H. Yang, “Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography,” Sensors (Basel) 16(12), 2111 (2016).
[Crossref] [PubMed]

Nikolayeva, E. V.

V. M. Bondarenko, G. N. Konovalova, E. V. Nikolayeva, A. N. Kuzikov, and E. V. Likhacheva, “Photodynamic effect of metal complexes of chlorin E6 derivatives on conditionally pathogenic bacteria using super-bright “cold” white light-emitting diodes,” Laser Medicine 12(2), 26–30 (2008).

Oh, H.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Oh, J.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Pardeshi, C. V.

M. V. Saner, A. D. Kulkarni, and C. V. Pardeshi, “Insights into drug delivery across the nail plate barrier,” J. Drug Target. 22(9), 769–789 (2014).
[Crossref] [PubMed]

M. V. Saner, A. D. Kulkarni, and C. V. Pardeshi, “Insights into drug delivery across the nail plate barrier,” J. Drug Target. 22(9), 769–789 (2014).
[Crossref] [PubMed]

Park, M. A.

Park, Y. O.

E. H. Lim, H. R. Kim, Y. O. Park, Y. Lee, Y. J. Seo, C. D. Kim, J. H. Lee, and M. Im, “Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream,” J. Am. Acad. Dermatol. 70(5), 918–923 (2014).
[Crossref] [PubMed]

Perry, M. D.

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

Peter, C.

C. Peter, D. Hongwan, A. Küpfer, and B. H. Lauterburg, “Pharmacokinetics and organ distribution of intravenous and oral methylene blue,” Eur. J. Clin. Pharmacol. 56(3), 247–250 (2000).
[Crossref] [PubMed]

Portnov, S. A.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Roth, F.

M. J. Myers, J. A. Myers, F. Roth, B. Guo, C. R. Hardy, S. Myers, A. Carrabba, C. B. S. Trywick, J. R. Griswold, and A. Mazzochi, “Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm,” Proc. of SPIE 8565, 85650W1 (2013).

Rubenchik, A. M.

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

Sakamoto, F. H.

M. Haedersdal, F. H. Sakamoto, W. A. Farinelli, A. G. Doukas, J. Tam, and R. R. Anderson, “Fractional CO(2) laser-assisted drug delivery,” Lasers Surg. Med. 42(2), 113–122 (2010).
[Crossref] [PubMed]

Saner, M. V.

M. V. Saner, A. D. Kulkarni, and C. V. Pardeshi, “Insights into drug delivery across the nail plate barrier,” J. Drug Target. 22(9), 769–789 (2014).
[Crossref] [PubMed]

M. V. Saner, A. D. Kulkarni, and C. V. Pardeshi, “Insights into drug delivery across the nail plate barrier,” J. Drug Target. 22(9), 769–789 (2014).
[Crossref] [PubMed]

Scher, R. K.

P. R. Cohen and R. K. Scher, “Geriatric nail disorders: diagnosis and treatment,” J. Am. Acad. Dermatol. 26(4), 521–531 (1992).
[Crossref] [PubMed]

Seo, Y. J.

E. H. Lim, H. R. Kim, Y. O. Park, Y. Lee, Y. J. Seo, C. D. Kim, J. H. Lee, and M. Im, “Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream,” J. Am. Acad. Dermatol. 70(5), 918–923 (2014).
[Crossref] [PubMed]

Sergeev, A. N.

A. V. Belikov, A. V. Skrypnik, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Er: YLF-laser microperforation of the nail plate for drug delivery,” Proc. SPIE 10716, 107160X (2018).

A. V. Belikov, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Microperforation of the human nail plate by radiation of erbium lasers,” Front Optoelectron. 10(3), 299–307 (2017).
[Crossref]

Sharma, S.

P. M. Sinha, G. Valco, S. Sharma, X. Liu, and M. Ferrari, “Nanoengineered device for drug delivery application,” Nanotechnology 15(10), S585–S589 (2004).
[Crossref]

Shatilova, K. V.

A. V. Belikov, A. V. Skrypnik, K. V. Shatilova, and V. V. Tuchin, “Multi-beam laser-induced hydrodynamic shock waves used for delivery of microparticles and liquids in skin,” Lasers Surg. Med. 47(9), 723–736 (2015).
[Crossref] [PubMed]

Shen, S. C.

M. T. Tsai, T. Y. Tsai, S. C. Shen, C. Y. Ng, Y. J. Lee, J. D. Lee, and C. H. Yang, “Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography,” Sensors (Basel) 16(12), 2111 (2016).
[Crossref] [PubMed]

W. R. Lee, S. C. Shen, S. A. Al-Suwayeh, H. H. Yang, C. Y. Yuan, and J. Y. Fang, “Laser-assisted topical drug delivery by using a low-fluence fractional laser: imiquimod and macromolecules,” J. Control. Release 153(3), 240–248 (2011).
[Crossref] [PubMed]

Shim, B. C.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Shinzato, D. H.

O. O. D. Morais, I. M. C. Costa, C. M. Gomes, D. H. Shinzato, G. M. C. Ayres, and R. M. Cardoso, “The use of the Er:YAG 2940nm laser associated with amorolfine lacquer in the treatment of onychomycosis,” An. Bras. Dermatol. 88(5), 847–849 (2013).
[PubMed]

Simmler, L.

I. Vejnovic, L. Simmler, and G. Betz, “Investigation of different formulations for drug delivery through the nail plate,” Int. J. Pharm. 386(1-2), 185–194 (2010).
[PubMed]

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P. M. Sinha, G. Valco, S. Sharma, X. Liu, and M. Ferrari, “Nanoengineered device for drug delivery application,” Nanotechnology 15(10), S585–S589 (2004).
[Crossref]

Sirotkin, F. V.

Skrypnik, A. V.

A. V. Belikov, A. V. Skrypnik, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Er: YLF-laser microperforation of the nail plate for drug delivery,” Proc. SPIE 10716, 107160X (2018).

A. V. Belikov, A. V. Skrypnik, K. V. Shatilova, and V. V. Tuchin, “Multi-beam laser-induced hydrodynamic shock waves used for delivery of microparticles and liquids in skin,” Lasers Surg. Med. 47(9), 723–736 (2015).
[Crossref] [PubMed]

Smirnov, S. N.

A. V. Belikov, A. V. Skrypnik, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Er: YLF-laser microperforation of the nail plate for drug delivery,” Proc. SPIE 10716, 107160X (2018).

A. V. Belikov, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Microperforation of the human nail plate by radiation of erbium lasers,” Front Optoelectron. 10(3), 299–307 (2017).
[Crossref]

Stuart, B. C.

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

Tam, J.

M. Haedersdal, F. H. Sakamoto, W. A. Farinelli, A. G. Doukas, J. Tam, and R. R. Anderson, “Fractional CO(2) laser-assisted drug delivery,” Lasers Surg. Med. 42(2), 113–122 (2010).
[Crossref] [PubMed]

Tavalinskaya, A. D.

A. V. Belikov, A. V. Skrypnik, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Er: YLF-laser microperforation of the nail plate for drug delivery,” Proc. SPIE 10716, 107160X (2018).

A. V. Belikov, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Microperforation of the human nail plate by radiation of erbium lasers,” Front Optoelectron. 10(3), 299–307 (2017).
[Crossref]

Trunina, N. A.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

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M. J. Myers, J. A. Myers, F. Roth, B. Guo, C. R. Hardy, S. Myers, A. Carrabba, C. B. S. Trywick, J. R. Griswold, and A. Mazzochi, “Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm,” Proc. of SPIE 8565, 85650W1 (2013).

Tsai, M. T.

M. T. Tsai, T. Y. Tsai, S. C. Shen, C. Y. Ng, Y. J. Lee, J. D. Lee, and C. H. Yang, “Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography,” Sensors (Basel) 16(12), 2111 (2016).
[Crossref] [PubMed]

Tsai, T. Y.

M. T. Tsai, T. Y. Tsai, S. C. Shen, C. Y. Ng, Y. J. Lee, J. D. Lee, and C. H. Yang, “Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography,” Sensors (Basel) 16(12), 2111 (2016).
[Crossref] [PubMed]

Tuchin, V. V.

A. V. Belikov, A. V. Skrypnik, K. V. Shatilova, and V. V. Tuchin, “Multi-beam laser-induced hydrodynamic shock waves used for delivery of microparticles and liquids in skin,” Lasers Surg. Med. 47(9), 723–736 (2015).
[Crossref] [PubMed]

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Valco, G.

P. M. Sinha, G. Valco, S. Sharma, X. Liu, and M. Ferrari, “Nanoengineered device for drug delivery application,” Nanotechnology 15(10), S585–S589 (2004).
[Crossref]

Vejnovic, I.

I. Vejnovic, L. Simmler, and G. Betz, “Investigation of different formulations for drug delivery through the nail plate,” Int. J. Pharm. 386(1-2), 185–194 (2010).
[PubMed]

Wiskirchen, D. E.

S. Narasimha Murthy, D. E. Wiskirchen, and C. P. Bowers, “Iontophoretic drug delivery across human nail,” J. Pharm. Sci. 96(2), 305–311 (2007).
[Crossref] [PubMed]

Yang, C. H.

M. T. Tsai, T. Y. Tsai, S. C. Shen, C. Y. Ng, Y. J. Lee, J. D. Lee, and C. H. Yang, “Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography,” Sensors (Basel) 16(12), 2111 (2016).
[Crossref] [PubMed]

Yang, H. H.

W. R. Lee, S. C. Shen, S. A. Al-Suwayeh, H. H. Yang, C. Y. Yuan, and J. Y. Fang, “Laser-assisted topical drug delivery by using a low-fluence fractional laser: imiquimod and macromolecules,” J. Control. Release 153(3), 240–248 (2011).
[Crossref] [PubMed]

Yang, Y.

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

Yoh, J. J.

M. A. Park, H. J. Jang, F. V. Sirotkin, and J. J. Yoh, “Er:YAG laser pulse for small-dose splashback-free microjet transdermal drug delivery,” Opt. Lett. 37(18), 3894–3896 (2012).
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T. H. Han and J. J. Yoh, “A laser based reusable microjet injector for transdermal drug delivery,” J. Appl. Phys. 107(10), 103110 (2010).
[Crossref]

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W. R. Lee, S. C. Shen, S. A. Al-Suwayeh, H. H. Yang, C. Y. Yuan, and J. Y. Fang, “Laser-assisted topical drug delivery by using a low-fluence fractional laser: imiquimod and macromolecules,” J. Control. Release 153(3), 240–248 (2011).
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P. A. Zelezny and S. E. Akimova, “A comparative review of dental materials used in the biological treatment of chronic forms of pulpitis in teeth with unformed roots,” Endodontics today 2(1), 3–6 (2013).

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O. O. D. Morais, I. M. C. Costa, C. M. Gomes, D. H. Shinzato, G. M. C. Ayres, and R. M. Cardoso, “The use of the Er:YAG 2940nm laser associated with amorolfine lacquer in the treatment of onychomycosis,” An. Bras. Dermatol. 88(5), 847–849 (2013).
[PubMed]

Endodontics today (1)

P. A. Zelezny and S. E. Akimova, “A comparative review of dental materials used in the biological treatment of chronic forms of pulpitis in teeth with unformed roots,” Endodontics today 2(1), 3–6 (2013).

Eur. J. Clin. Pharmacol. (1)

C. Peter, D. Hongwan, A. Küpfer, and B. H. Lauterburg, “Pharmacokinetics and organ distribution of intravenous and oral methylene blue,” Eur. J. Clin. Pharmacol. 56(3), 247–250 (2000).
[Crossref] [PubMed]

Expert Opin. Drug Deliv. (1)

S. Murdan, “Enhancing the nail permeability of topically applied drugs,” Expert Opin. Drug Deliv. 5(11), 1267–1282 (2008).
[Crossref] [PubMed]

Front Optoelectron. (1)

A. V. Belikov, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Microperforation of the human nail plate by radiation of erbium lasers,” Front Optoelectron. 10(3), 299–307 (2017).
[Crossref]

Int. J. Pharm. (3)

S. Murdan, “Drug delivery to the nail following topical application,” Int. J. Pharm. 236(1-2), 1–26 (2002).
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R. Elkeeb, A. AliKhan, L. Elkeeb, X. Hui, and H. I. Maibach, “Transungual drug delivery: current status,” Int. J. Pharm. 384(1-2), 1–8 (2010).
[Crossref] [PubMed]

I. Vejnovic, L. Simmler, and G. Betz, “Investigation of different formulations for drug delivery through the nail plate,” Int. J. Pharm. 386(1-2), 185–194 (2010).
[PubMed]

J. Am. Acad. Dermatol. (2)

E. H. Lim, H. R. Kim, Y. O. Park, Y. Lee, Y. J. Seo, C. D. Kim, J. H. Lee, and M. Im, “Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream,” J. Am. Acad. Dermatol. 70(5), 918–923 (2014).
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P. R. Cohen and R. K. Scher, “Geriatric nail disorders: diagnosis and treatment,” J. Am. Acad. Dermatol. 26(4), 521–531 (1992).
[Crossref] [PubMed]

J. Appl. Phys. (1)

T. H. Han and J. J. Yoh, “A laser based reusable microjet injector for transdermal drug delivery,” J. Appl. Phys. 107(10), 103110 (2010).
[Crossref]

J. Control. Release (1)

W. R. Lee, S. C. Shen, S. A. Al-Suwayeh, H. H. Yang, C. Y. Yuan, and J. Y. Fang, “Laser-assisted topical drug delivery by using a low-fluence fractional laser: imiquimod and macromolecules,” J. Control. Release 153(3), 240–248 (2011).
[Crossref] [PubMed]

J. Drug Target. (2)

M. V. Saner, A. D. Kulkarni, and C. V. Pardeshi, “Insights into drug delivery across the nail plate barrier,” J. Drug Target. 22(9), 769–789 (2014).
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M. V. Saner, A. D. Kulkarni, and C. V. Pardeshi, “Insights into drug delivery across the nail plate barrier,” J. Drug Target. 22(9), 769–789 (2014).
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J. Pharm. Sci. (1)

S. Narasimha Murthy, D. E. Wiskirchen, and C. P. Bowers, “Iontophoretic drug delivery across human nail,” J. Pharm. Sci. 96(2), 305–311 (2007).
[Crossref] [PubMed]

Journal of the Laser and Health Academy (1)

J. Kozarev, “Novel laser therapy in treatment of onychomycosis,” Journal of the Laser and Health Academy 2010(1), 1–8 (2010).

Laser Medicine (1)

V. M. Bondarenko, G. N. Konovalova, E. V. Nikolayeva, A. N. Kuzikov, and E. V. Likhacheva, “Photodynamic effect of metal complexes of chlorin E6 derivatives on conditionally pathogenic bacteria using super-bright “cold” white light-emitting diodes,” Laser Medicine 12(2), 26–30 (2008).

Lasers Surg. Med. (4)

M. Haedersdal, F. H. Sakamoto, W. A. Farinelli, A. G. Doukas, J. Tam, and R. R. Anderson, “Fractional CO(2) laser-assisted drug delivery,” Lasers Surg. Med. 42(2), 113–122 (2010).
[Crossref] [PubMed]

A. V. Belikov, A. V. Skrypnik, K. V. Shatilova, and V. V. Tuchin, “Multi-beam laser-induced hydrodynamic shock waves used for delivery of microparticles and liquids in skin,” Lasers Surg. Med. 47(9), 723–736 (2015).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

J. Neev, J. S. Nelson, M. Critelli, J. L. McCullough, E. Cheung, W. A. Carrasco, A. M. Rubenchik, L. B. Da Silva, M. D. Perry, and B. C. Stuart, “Ablation of human nail by pulsed lasers,” Lasers Surg. Med. 21(2), 186–192 (1997).
[Crossref] [PubMed]

Nanotechnology (1)

P. M. Sinha, G. Valco, S. Sharma, X. Liu, and M. Ferrari, “Nanoengineered device for drug delivery application,” Nanotechnology 15(10), S585–S589 (2004).
[Crossref]

Opt. Lett. (1)

Proc. of SPIE (1)

M. J. Myers, J. A. Myers, F. Roth, B. Guo, C. R. Hardy, S. Myers, A. Carrabba, C. B. S. Trywick, J. R. Griswold, and A. Mazzochi, “Treatment of toe nail fungus infection using an AO Q-switched eye-safe erbium glass laser at 1534nm,” Proc. of SPIE 8565, 85650W1 (2013).

Proc. SPIE (2)

V. V. Tuchin, A. N. Bashkatov, E. A. Genina, V. I. Kochubey, V. V. Lychagov, S. A. Portnov, N. A. Trunina, S. Cho, H. Oh, B. C. Shim, M. Kim, J. Oh, H. Eum, Y. Ku, D. Kim, Y. Yang, and D. R. Miller, “Finger tissue model and blood perfused skin tissue phantom,” Proc. SPIE 7898, 78980Z (2011).
[Crossref]

A. V. Belikov, A. V. Skrypnik, A. N. Sergeev, S. N. Smirnov, and A. D. Tavalinskaya, “Er: YLF-laser microperforation of the nail plate for drug delivery,” Proc. SPIE 10716, 107160X (2018).

Russian Biotherapeutic J (1)

A. P. Bobrov and A. N. Badmaeva, “The use of photoditazin in the treatment of inflammatory periodontal diseases caused by dentures,” Russian Biotherapeutic J.  7, 4 (2008).

Sensors (Basel) (1)

M. T. Tsai, T. Y. Tsai, S. C. Shen, C. Y. Ng, Y. J. Lee, J. D. Lee, and C. H. Yang, “Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography,” Sensors (Basel) 16(12), 2111 (2016).
[Crossref] [PubMed]

Surgery News (1)

S. E. Katorkin and M. V. Nasyrov, “The use of photodynamic therapy in local treatment and preoperative preparation of trophic ulcers of venous etiology,” Surgery News 23, 2 (2015).

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A. V. Vladimirova, Functional characteristics of microspherical carriers of biologically active substances for reconstructive soft tissue technologies (Doctoral dissertation, Siberian Federal University, 2018).

P. H. Sugarbaker and M. M. Malawer, Musculoskeletal Surgery for Cancer: Principles and Techniques (Thieme Medical Pub, 1992).

D. Sa, G. F. Ferreira, C. A. L. De Serpa Soares, and L.G. D. S. A. Moreira. “Device for efficient delivery of compounds to or through the skin or biological barriers, using light-absorbing thin films.” U.S. Patent Application No. 14/113,148.

A. Torkar, J. Kristl, and S. Murdan, Low-frequency Ultrasound to Enhance Topical Drug Delivery to the Nail (The School of Pharmacy, 2007).

Yu. V. Sergeev, E. V. Mokina, A. Yu. Sergeev, G. N. Burtseva, M. O. Baranova, N. V. Savchenko, and V. Yu. Sergeev, Local and Combined Therapy of Onychomycosis (National Academy of Mycology, 2013).

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Figures (4)

Fig. 1
Fig. 1 Scheme of the experimental setup (a): 1 – Er:YLF-laser; 2 – collecting lens (F = 50 mm), 3 – gel plate; 4 –nail plate sample; 5 – paper substrate; 6 – glass slide; 7 – fastening screws; 8 – XZ-translator; 9 – digital USB-microscope “DTX 50” (Levenhuk, Inc., USA); 10 – Z-translator; 11 – computer; oscillogram of Er:YLF-laser radiation pulse (E = 4 mJ) (b).
Fig. 2
Fig. 2 Photos of the MB-containing gel with 0.5%, 1%, 2% and 3% concentration of agar-agar (transmitted light).
Fig. 3
Fig. 3 Dependence of the number of Er:YLF-laser pulses required for through microperforation of the gel (Ngp) on the concentration Caa of agar-agar in it (a) and on the gel plate thickness hg (b) (E = 4.0 mJ).
Fig. 4
Fig. 4 Dependence of the delivery rate (VMB) for gel with Caa = 2% on laser pulse energy (E) at P = 1.3 kPa (a), on the gel plate thickness (hg) at E = 4.0 mJ and P = 1.3 kPa (b), on the magnitude of the external pressure (P) applied to the gel for the extraction of the MB from it at E = 4.0 mJ and hg = 500 μm (c).

Tables (1)

Tables Icon

Table 1 Results of Ngp, Nnp, Nnd, NΣ measurements at different values of hg and Caa (E = 4.0 ± 0.1 mJ)