Abstract

Quantitative phase imaging methods have several advantages when it comes to monitoring cultures of adherent mammalian cells. Because of low photo-toxicity and no need for staining, we can follow cells in a minimally invasive way over a long period of time. The ability to measure the optical path difference in a quantitative manner allows the measurement of the cell dry mass, an important metric for studying the growth kinetics of mammalian cells. Here we present and compare cell measurements obtained with three different techniques: digital holographic microscopy, lens-free microscopy and quadriwave lateral sheering interferometry. We report a linear relationship between optical volume density values measured with these different techniques and estimate the precisions of this measurement for the different individual instruments.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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2018 (3)

Y. Park, C. Depeursinge, and G. Popescu, “Quantitative phase imaging in biomedicine,” Nat. Photonics 12, 578 (2018).
[Crossref]

C. Allier, R. Vincent, F. Navarro, M. Menneteau, L. Ghenim, X. Gidrol, T. Bordy, L. Hervé, O. Cioni, S. Bardin, and et al., “Lens-free video microscopy for the dynamic and quantitative analysis of adherent cell culture,” J. visualized experiments: JoVE 132, e56580 (2018).

L. Herve, O. Cioni, P. Blandin, F. Navarro, M. Menneteau, T. Bordy, S. Morales, and C. Allier, “Multispectral total-variation reconstruction applied to lens-free microscopy,” Biomed. Opt. Express 9, 5828–5836 (2018).
[Crossref] [PubMed]

2017 (3)

C. Allier, S. Morel, R. Vincent, L. Ghenim, F. Navarro, M. Menneteau, T. Bordy, L. Hervé, O. Cioni, and X. Gidrol, “Imaging of dense cell cultures by multiwavelength lens-free video microscopy,” Cytom. Part A 91, 433–442 (2017).
[Crossref]

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
[Crossref] [PubMed]

M. Hejna, A. Jorapur, J. S. Song, and R. L. Judson, “High accuracy label-free classification of single-cell kinetic states from holographic cytometry of human melanoma cells,” Sci. reports 7, 11943 (2017).
[Crossref]

2015 (1)

S. Aknoun, J. Savatier, P. Bon, F. Galland, L. Abdeladim, B. F. Wattellier, and S. Monneret, “Living cell dry mass measurement using quantitative phase imaging with quadriwave lateral shearing interferometry: an accuracy and sensitivity discussion,” J. biomedical optics 20, 126009 (2015).
[Crossref]

2012 (2)

M. Mir, B. Bhaduri, R. Wang, R. Zhu, and G. Popescu, “Quantitative phase imaging,” Prog. Opt. 57, 133–217 (2012).
[Crossref]

P. Bon, J. Savatier, M. Merlin, S. Monneret, and B. F. Wattellier, “Optical detection and measurement of living cell morphometric features with single-shot quantitative phase microscopy,” J. Biomed. Opt. 17, 076004 (2012).
[Crossref] [PubMed]

2011 (2)

J. Reed, J. Chun, T. A. Zangle, S. Kalim, J. S. Hong, S. E. Pefley, X. Zheng, J. K. Gimzewski, and M. A. Teitell, “Rapid, massively parallel single-cell drug response measurements via live cell interferometry,” Biophys. journal 101, 1025–1031 (2011).
[Crossref]

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. 108, 13124–13129 (2011).
[Crossref] [PubMed]

2010 (1)

K. Park, L. J. Millet, N. Kim, H. Li, X. Jin, G. Popescu, N. Aluru, K. J. Hsia, and R. Bashir, “Measurement of adherent cell mass and growth,” Proc. Natl. Acad. Sci. 107, 20691–20696 (2010).
[Crossref] [PubMed]

2009 (3)

T.-W. Su, S. Seo, A. Erlinger, and A. Ozcan, “High-throughput lensfree imaging and characterization of a heterogeneous cell solution on a chip,” Biotechnol. bioengineering 102, 856–868 (2009).
[Crossref]

P. Bon, G. Maucort, B. Wattellier, and S. Monneret, “Quadriwave lateral shearing interferometry for quantitative phase microscopy of living cells,” Opt. express 17, 13080–13094 (2009).
[Crossref] [PubMed]

S. Seo, T.-W. Su, D. K. Tseng, A. Erlinger, and A. Ozcan, “Lensfree holographic imaging for on-chip cytometry and diagnostics,” Lab on a Chip 9, 777–787 (2009).
[Crossref] [PubMed]

2008 (1)

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Physiol. 295, C538–C544 (2008).
[Crossref]

2005 (1)

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. letters 30, 468–470 (2005).
[Crossref]

2001 (1)

1982 (1)

J. R. Fienup, “Phase retrieval algorithms: a comparison,” Appl. optics 21, 2758–2769 (1982).
[Crossref]

1952 (2)

R. Barer, “Interference microscopy and mass determination,” Nature 169, 366 (1952).
[Crossref] [PubMed]

H. Davies and M. Wilkins, “Interference microscopy and mass determination,” Nature 169, 541 (1952).
[Crossref] [PubMed]

Abdeladim, L.

S. Aknoun, J. Savatier, P. Bon, F. Galland, L. Abdeladim, B. F. Wattellier, and S. Monneret, “Living cell dry mass measurement using quantitative phase imaging with quadriwave lateral shearing interferometry: an accuracy and sensitivity discussion,” J. biomedical optics 20, 126009 (2015).
[Crossref]

Aknoun, S.

S. Aknoun, J. Savatier, P. Bon, F. Galland, L. Abdeladim, B. F. Wattellier, and S. Monneret, “Living cell dry mass measurement using quantitative phase imaging with quadriwave lateral shearing interferometry: an accuracy and sensitivity discussion,” J. biomedical optics 20, 126009 (2015).
[Crossref]

S. Monneret, P. Bon, G. Baffou, P. Berto, J. Savatier, S. Aknoun, and H. Rigneault, “Quadriwave lateral shearing interferometry as a quantification tool for microscopy. application to dry mass determination of living cells, temperature mapping, and vibrational phase imaging,” in Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, vol. 8792 (International Society for Optics and Photonics, 2013), p. 879209.
[Crossref]

Allier, C.

C. Allier, R. Vincent, F. Navarro, M. Menneteau, L. Ghenim, X. Gidrol, T. Bordy, L. Hervé, O. Cioni, S. Bardin, and et al., “Lens-free video microscopy for the dynamic and quantitative analysis of adherent cell culture,” J. visualized experiments: JoVE 132, e56580 (2018).

L. Herve, O. Cioni, P. Blandin, F. Navarro, M. Menneteau, T. Bordy, S. Morales, and C. Allier, “Multispectral total-variation reconstruction applied to lens-free microscopy,” Biomed. Opt. Express 9, 5828–5836 (2018).
[Crossref] [PubMed]

C. Allier, S. Morel, R. Vincent, L. Ghenim, F. Navarro, M. Menneteau, T. Bordy, L. Hervé, O. Cioni, and X. Gidrol, “Imaging of dense cell cultures by multiwavelength lens-free video microscopy,” Cytom. Part A 91, 433–442 (2017).
[Crossref]

Aluru, N.

K. Park, L. J. Millet, N. Kim, H. Li, X. Jin, G. Popescu, N. Aluru, K. J. Hsia, and R. Bashir, “Measurement of adherent cell mass and growth,” Proc. Natl. Acad. Sci. 107, 20691–20696 (2010).
[Crossref] [PubMed]

Badizadegan, K.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Physiol. 295, C538–C544 (2008).
[Crossref]

Baffou, G.

S. Monneret, P. Bon, G. Baffou, P. Berto, J. Savatier, S. Aknoun, and H. Rigneault, “Quadriwave lateral shearing interferometry as a quantification tool for microscopy. application to dry mass determination of living cells, temperature mapping, and vibrational phase imaging,” in Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, vol. 8792 (International Society for Optics and Photonics, 2013), p. 879209.
[Crossref]

Bardin, S.

C. Allier, R. Vincent, F. Navarro, M. Menneteau, L. Ghenim, X. Gidrol, T. Bordy, L. Hervé, O. Cioni, S. Bardin, and et al., “Lens-free video microscopy for the dynamic and quantitative analysis of adherent cell culture,” J. visualized experiments: JoVE 132, e56580 (2018).

Barer, R.

R. Barer, “Interference microscopy and mass determination,” Nature 169, 366 (1952).
[Crossref] [PubMed]

Bashir, R.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. 108, 13124–13129 (2011).
[Crossref] [PubMed]

K. Park, L. J. Millet, N. Kim, H. Li, X. Jin, G. Popescu, N. Aluru, K. J. Hsia, and R. Bashir, “Measurement of adherent cell mass and growth,” Proc. Natl. Acad. Sci. 107, 20691–20696 (2010).
[Crossref] [PubMed]

Bednarz, M.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. 108, 13124–13129 (2011).
[Crossref] [PubMed]

Bensch, R.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
[Crossref] [PubMed]

Berto, P.

S. Monneret, P. Bon, G. Baffou, P. Berto, J. Savatier, S. Aknoun, and H. Rigneault, “Quadriwave lateral shearing interferometry as a quantification tool for microscopy. application to dry mass determination of living cells, temperature mapping, and vibrational phase imaging,” in Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, vol. 8792 (International Society for Optics and Photonics, 2013), p. 879209.
[Crossref]

Best-Popescu, C.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Physiol. 295, C538–C544 (2008).
[Crossref]

Bhaduri, B.

M. Mir, B. Bhaduri, R. Wang, R. Zhu, and G. Popescu, “Quantitative phase imaging,” Prog. Opt. 57, 133–217 (2012).
[Crossref]

Blandin, P.

Blau, H. M.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
[Crossref] [PubMed]

Bon, P.

S. Aknoun, J. Savatier, P. Bon, F. Galland, L. Abdeladim, B. F. Wattellier, and S. Monneret, “Living cell dry mass measurement using quantitative phase imaging with quadriwave lateral shearing interferometry: an accuracy and sensitivity discussion,” J. biomedical optics 20, 126009 (2015).
[Crossref]

P. Bon, J. Savatier, M. Merlin, S. Monneret, and B. F. Wattellier, “Optical detection and measurement of living cell morphometric features with single-shot quantitative phase microscopy,” J. Biomed. Opt. 17, 076004 (2012).
[Crossref] [PubMed]

P. Bon, G. Maucort, B. Wattellier, and S. Monneret, “Quadriwave lateral shearing interferometry for quantitative phase microscopy of living cells,” Opt. express 17, 13080–13094 (2009).
[Crossref] [PubMed]

S. Monneret, P. Bon, G. Baffou, P. Berto, J. Savatier, S. Aknoun, and H. Rigneault, “Quadriwave lateral shearing interferometry as a quantification tool for microscopy. application to dry mass determination of living cells, temperature mapping, and vibrational phase imaging,” in Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, vol. 8792 (International Society for Optics and Photonics, 2013), p. 879209.
[Crossref]

Bordy, T.

C. Allier, R. Vincent, F. Navarro, M. Menneteau, L. Ghenim, X. Gidrol, T. Bordy, L. Hervé, O. Cioni, S. Bardin, and et al., “Lens-free video microscopy for the dynamic and quantitative analysis of adherent cell culture,” J. visualized experiments: JoVE 132, e56580 (2018).

L. Herve, O. Cioni, P. Blandin, F. Navarro, M. Menneteau, T. Bordy, S. Morales, and C. Allier, “Multispectral total-variation reconstruction applied to lens-free microscopy,” Biomed. Opt. Express 9, 5828–5836 (2018).
[Crossref] [PubMed]

C. Allier, S. Morel, R. Vincent, L. Ghenim, F. Navarro, M. Menneteau, T. Bordy, L. Hervé, O. Cioni, and X. Gidrol, “Imaging of dense cell cultures by multiwavelength lens-free video microscopy,” Cytom. Part A 91, 433–442 (2017).
[Crossref]

Brox, T.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
[Crossref] [PubMed]

Cho, S.-Y.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
[Crossref] [PubMed]

Chun, J.

J. Reed, J. Chun, T. A. Zangle, S. Kalim, J. S. Hong, S. E. Pefley, X. Zheng, J. K. Gimzewski, and M. A. Teitell, “Rapid, massively parallel single-cell drug response measurements via live cell interferometry,” Biophys. journal 101, 1025–1031 (2011).
[Crossref]

Cioni, O.

C. Allier, R. Vincent, F. Navarro, M. Menneteau, L. Ghenim, X. Gidrol, T. Bordy, L. Hervé, O. Cioni, S. Bardin, and et al., “Lens-free video microscopy for the dynamic and quantitative analysis of adherent cell culture,” J. visualized experiments: JoVE 132, e56580 (2018).

L. Herve, O. Cioni, P. Blandin, F. Navarro, M. Menneteau, T. Bordy, S. Morales, and C. Allier, “Multispectral total-variation reconstruction applied to lens-free microscopy,” Biomed. Opt. Express 9, 5828–5836 (2018).
[Crossref] [PubMed]

C. Allier, S. Morel, R. Vincent, L. Ghenim, F. Navarro, M. Menneteau, T. Bordy, L. Hervé, O. Cioni, and X. Gidrol, “Imaging of dense cell cultures by multiwavelength lens-free video microscopy,” Cytom. Part A 91, 433–442 (2017).
[Crossref]

Colomb, T.

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. letters 30, 468–470 (2005).
[Crossref]

Cuche, E.

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Meijering, E.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
[Crossref] [PubMed]

Menneteau, M.

C. Allier, R. Vincent, F. Navarro, M. Menneteau, L. Ghenim, X. Gidrol, T. Bordy, L. Hervé, O. Cioni, S. Bardin, and et al., “Lens-free video microscopy for the dynamic and quantitative analysis of adherent cell culture,” J. visualized experiments: JoVE 132, e56580 (2018).

L. Herve, O. Cioni, P. Blandin, F. Navarro, M. Menneteau, T. Bordy, S. Morales, and C. Allier, “Multispectral total-variation reconstruction applied to lens-free microscopy,” Biomed. Opt. Express 9, 5828–5836 (2018).
[Crossref] [PubMed]

C. Allier, S. Morel, R. Vincent, L. Ghenim, F. Navarro, M. Menneteau, T. Bordy, L. Hervé, O. Cioni, and X. Gidrol, “Imaging of dense cell cultures by multiwavelength lens-free video microscopy,” Cytom. Part A 91, 433–442 (2017).
[Crossref]

Merlin, M.

P. Bon, J. Savatier, M. Merlin, S. Monneret, and B. F. Wattellier, “Optical detection and measurement of living cell morphometric features with single-shot quantitative phase microscopy,” J. Biomed. Opt. 17, 076004 (2012).
[Crossref] [PubMed]

Meucci, R.

Mikut, R.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
[Crossref] [PubMed]

Millet, L. J.

K. Park, L. J. Millet, N. Kim, H. Li, X. Jin, G. Popescu, N. Aluru, K. J. Hsia, and R. Bashir, “Measurement of adherent cell mass and growth,” Proc. Natl. Acad. Sci. 107, 20691–20696 (2010).
[Crossref] [PubMed]

Mir, M.

M. Mir, B. Bhaduri, R. Wang, R. Zhu, and G. Popescu, “Quantitative phase imaging,” Prog. Opt. 57, 133–217 (2012).
[Crossref]

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. 108, 13124–13129 (2011).
[Crossref] [PubMed]

Monneret, S.

S. Aknoun, J. Savatier, P. Bon, F. Galland, L. Abdeladim, B. F. Wattellier, and S. Monneret, “Living cell dry mass measurement using quantitative phase imaging with quadriwave lateral shearing interferometry: an accuracy and sensitivity discussion,” J. biomedical optics 20, 126009 (2015).
[Crossref]

P. Bon, J. Savatier, M. Merlin, S. Monneret, and B. F. Wattellier, “Optical detection and measurement of living cell morphometric features with single-shot quantitative phase microscopy,” J. Biomed. Opt. 17, 076004 (2012).
[Crossref] [PubMed]

P. Bon, G. Maucort, B. Wattellier, and S. Monneret, “Quadriwave lateral shearing interferometry for quantitative phase microscopy of living cells,” Opt. express 17, 13080–13094 (2009).
[Crossref] [PubMed]

S. Monneret, P. Bon, G. Baffou, P. Berto, J. Savatier, S. Aknoun, and H. Rigneault, “Quadriwave lateral shearing interferometry as a quantification tool for microscopy. application to dry mass determination of living cells, temperature mapping, and vibrational phase imaging,” in Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, vol. 8792 (International Society for Optics and Photonics, 2013), p. 879209.
[Crossref]

Morales, S.

Morel, S.

C. Allier, S. Morel, R. Vincent, L. Ghenim, F. Navarro, M. Menneteau, T. Bordy, L. Hervé, O. Cioni, and X. Gidrol, “Imaging of dense cell cultures by multiwavelength lens-free video microscopy,” Cytom. Part A 91, 433–442 (2017).
[Crossref]

Muñoz Barrutia, A.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
[Crossref] [PubMed]

Navarro, F.

C. Allier, R. Vincent, F. Navarro, M. Menneteau, L. Ghenim, X. Gidrol, T. Bordy, L. Hervé, O. Cioni, S. Bardin, and et al., “Lens-free video microscopy for the dynamic and quantitative analysis of adherent cell culture,” J. visualized experiments: JoVE 132, e56580 (2018).

L. Herve, O. Cioni, P. Blandin, F. Navarro, M. Menneteau, T. Bordy, S. Morales, and C. Allier, “Multispectral total-variation reconstruction applied to lens-free microscopy,” Biomed. Opt. Express 9, 5828–5836 (2018).
[Crossref] [PubMed]

C. Allier, S. Morel, R. Vincent, L. Ghenim, F. Navarro, M. Menneteau, T. Bordy, L. Hervé, O. Cioni, and X. Gidrol, “Imaging of dense cell cultures by multiwavelength lens-free video microscopy,” Cytom. Part A 91, 433–442 (2017).
[Crossref]

Olivo-Marin, J.-C.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
[Crossref] [PubMed]

Ortiz-de Solorzano, C.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
[Crossref] [PubMed]

Ozcan, A.

T.-W. Su, S. Seo, A. Erlinger, and A. Ozcan, “High-throughput lensfree imaging and characterization of a heterogeneous cell solution on a chip,” Biotechnol. bioengineering 102, 856–868 (2009).
[Crossref]

S. Seo, T.-W. Su, D. K. Tseng, A. Erlinger, and A. Ozcan, “Lensfree holographic imaging for on-chip cytometry and diagnostics,” Lab on a Chip 9, 777–787 (2009).
[Crossref] [PubMed]

Park, K.

K. Park, L. J. Millet, N. Kim, H. Li, X. Jin, G. Popescu, N. Aluru, K. J. Hsia, and R. Bashir, “Measurement of adherent cell mass and growth,” Proc. Natl. Acad. Sci. 107, 20691–20696 (2010).
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Y. Park, C. Depeursinge, and G. Popescu, “Quantitative phase imaging in biomedicine,” Nat. Photonics 12, 578 (2018).
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G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Physiol. 295, C538–C544 (2008).
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Pefley, S. E.

J. Reed, J. Chun, T. A. Zangle, S. Kalim, J. S. Hong, S. E. Pefley, X. Zheng, J. K. Gimzewski, and M. A. Teitell, “Rapid, massively parallel single-cell drug response measurements via live cell interferometry,” Biophys. journal 101, 1025–1031 (2011).
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Pierattini, G.

Popescu, G.

Y. Park, C. Depeursinge, and G. Popescu, “Quantitative phase imaging in biomedicine,” Nat. Photonics 12, 578 (2018).
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M. Mir, B. Bhaduri, R. Wang, R. Zhu, and G. Popescu, “Quantitative phase imaging,” Prog. Opt. 57, 133–217 (2012).
[Crossref]

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. 108, 13124–13129 (2011).
[Crossref] [PubMed]

K. Park, L. J. Millet, N. Kim, H. Li, X. Jin, G. Popescu, N. Aluru, K. J. Hsia, and R. Bashir, “Measurement of adherent cell mass and growth,” Proc. Natl. Acad. Sci. 107, 20691–20696 (2010).
[Crossref] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Physiol. 295, C538–C544 (2008).
[Crossref]

Prasanth, S. G.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. 108, 13124–13129 (2011).
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Quelhas, P.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
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Radojevic, M.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
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Rappaz, B.

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. letters 30, 468–470 (2005).
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J. Reed, J. Chun, T. A. Zangle, S. Kalim, J. S. Hong, S. E. Pefley, X. Zheng, J. K. Gimzewski, and M. A. Teitell, “Rapid, massively parallel single-cell drug response measurements via live cell interferometry,” Biophys. journal 101, 1025–1031 (2011).
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Reyes-Aldasoro, C. C.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
[Crossref] [PubMed]

Rigneault, H.

S. Monneret, P. Bon, G. Baffou, P. Berto, J. Savatier, S. Aknoun, and H. Rigneault, “Quadriwave lateral shearing interferometry as a quantification tool for microscopy. application to dry mass determination of living cells, temperature mapping, and vibrational phase imaging,” in Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, vol. 8792 (International Society for Optics and Photonics, 2013), p. 879209.
[Crossref]

Rohr, K.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
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Ronneberger, O.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
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Savatier, J.

S. Aknoun, J. Savatier, P. Bon, F. Galland, L. Abdeladim, B. F. Wattellier, and S. Monneret, “Living cell dry mass measurement using quantitative phase imaging with quadriwave lateral shearing interferometry: an accuracy and sensitivity discussion,” J. biomedical optics 20, 126009 (2015).
[Crossref]

P. Bon, J. Savatier, M. Merlin, S. Monneret, and B. F. Wattellier, “Optical detection and measurement of living cell morphometric features with single-shot quantitative phase microscopy,” J. Biomed. Opt. 17, 076004 (2012).
[Crossref] [PubMed]

S. Monneret, P. Bon, G. Baffou, P. Berto, J. Savatier, S. Aknoun, and H. Rigneault, “Quadriwave lateral shearing interferometry as a quantification tool for microscopy. application to dry mass determination of living cells, temperature mapping, and vibrational phase imaging,” in Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, vol. 8792 (International Society for Optics and Photonics, 2013), p. 879209.
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Seo, S.

S. Seo, T.-W. Su, D. K. Tseng, A. Erlinger, and A. Ozcan, “Lensfree holographic imaging for on-chip cytometry and diagnostics,” Lab on a Chip 9, 777–787 (2009).
[Crossref] [PubMed]

T.-W. Su, S. Seo, A. Erlinger, and A. Ozcan, “High-throughput lensfree imaging and characterization of a heterogeneous cell solution on a chip,” Biotechnol. bioengineering 102, 856–868 (2009).
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Shen, Z.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. 108, 13124–13129 (2011).
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Smal, I.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
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A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
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A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
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Su, T.-W.

T.-W. Su, S. Seo, A. Erlinger, and A. Ozcan, “High-throughput lensfree imaging and characterization of a heterogeneous cell solution on a chip,” Biotechnol. bioengineering 102, 856–868 (2009).
[Crossref]

S. Seo, T.-W. Su, D. K. Tseng, A. Erlinger, and A. Ozcan, “Lensfree holographic imaging for on-chip cytometry and diagnostics,” Lab on a Chip 9, 777–787 (2009).
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Svoboda, D.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
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Teitell, M. A.

J. Reed, J. Chun, T. A. Zangle, S. Kalim, J. S. Hong, S. E. Pefley, X. Zheng, J. K. Gimzewski, and M. A. Teitell, “Rapid, massively parallel single-cell drug response measurements via live cell interferometry,” Biophys. journal 101, 1025–1031 (2011).
[Crossref]

Tomancak, P.

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
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C. Allier, S. Morel, R. Vincent, L. Ghenim, F. Navarro, M. Menneteau, T. Bordy, L. Hervé, O. Cioni, and X. Gidrol, “Imaging of dense cell cultures by multiwavelength lens-free video microscopy,” Cytom. Part A 91, 433–442 (2017).
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M. Mir, B. Bhaduri, R. Wang, R. Zhu, and G. Popescu, “Quantitative phase imaging,” Prog. Opt. 57, 133–217 (2012).
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Wang, Z.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. 108, 13124–13129 (2011).
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P. Bon, J. Savatier, M. Merlin, S. Monneret, and B. F. Wattellier, “Optical detection and measurement of living cell morphometric features with single-shot quantitative phase microscopy,” J. Biomed. Opt. 17, 076004 (2012).
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J. Reed, J. Chun, T. A. Zangle, S. Kalim, J. S. Hong, S. E. Pefley, X. Zheng, J. K. Gimzewski, and M. A. Teitell, “Rapid, massively parallel single-cell drug response measurements via live cell interferometry,” Biophys. journal 101, 1025–1031 (2011).
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M. Mir, B. Bhaduri, R. Wang, R. Zhu, and G. Popescu, “Quantitative phase imaging,” Prog. Opt. 57, 133–217 (2012).
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Am. J. Physiol. Physiol. (1)

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Physiol. 295, C538–C544 (2008).
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Biomed. Opt. Express (1)

Biophys. journal (1)

J. Reed, J. Chun, T. A. Zangle, S. Kalim, J. S. Hong, S. E. Pefley, X. Zheng, J. K. Gimzewski, and M. A. Teitell, “Rapid, massively parallel single-cell drug response measurements via live cell interferometry,” Biophys. journal 101, 1025–1031 (2011).
[Crossref]

Biotechnol. bioengineering (1)

T.-W. Su, S. Seo, A. Erlinger, and A. Ozcan, “High-throughput lensfree imaging and characterization of a heterogeneous cell solution on a chip,” Biotechnol. bioengineering 102, 856–868 (2009).
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Cytom. Part A (1)

C. Allier, S. Morel, R. Vincent, L. Ghenim, F. Navarro, M. Menneteau, T. Bordy, L. Hervé, O. Cioni, and X. Gidrol, “Imaging of dense cell cultures by multiwavelength lens-free video microscopy,” Cytom. Part A 91, 433–442 (2017).
[Crossref]

J. Biomed. Opt. (1)

P. Bon, J. Savatier, M. Merlin, S. Monneret, and B. F. Wattellier, “Optical detection and measurement of living cell morphometric features with single-shot quantitative phase microscopy,” J. Biomed. Opt. 17, 076004 (2012).
[Crossref] [PubMed]

J. biomedical optics (1)

S. Aknoun, J. Savatier, P. Bon, F. Galland, L. Abdeladim, B. F. Wattellier, and S. Monneret, “Living cell dry mass measurement using quantitative phase imaging with quadriwave lateral shearing interferometry: an accuracy and sensitivity discussion,” J. biomedical optics 20, 126009 (2015).
[Crossref]

J. visualized experiments: JoVE (1)

C. Allier, R. Vincent, F. Navarro, M. Menneteau, L. Ghenim, X. Gidrol, T. Bordy, L. Hervé, O. Cioni, S. Bardin, and et al., “Lens-free video microscopy for the dynamic and quantitative analysis of adherent cell culture,” J. visualized experiments: JoVE 132, e56580 (2018).

Lab on a Chip (1)

S. Seo, T.-W. Su, D. K. Tseng, A. Erlinger, and A. Ozcan, “Lensfree holographic imaging for on-chip cytometry and diagnostics,” Lab on a Chip 9, 777–787 (2009).
[Crossref] [PubMed]

Nat. Methods (1)

A. Muñoz Barrutia, S. Wolf, R. Mikut, C. C. Reyes-Aldasoro, H. M. Blau, L. Malmström, S.-Y. Cho, V. Ulman, P. Matula, F. Jug, M. Kozubek, E. Meijering, P. Quelhas, O. Dzyubachyk, J.-C. Olivo-Marin, F. a. Hamprecht, T. Esteves, J. Jaldén, D. Svoboda, M. Maška, O. Ronneberger, R. Bensch, T. Brox, P. Tomancak, J. a. Solis-Lemus, C. Haubold, A. C. Dufour, P. Matula, B. Lelieveldt, J. Stegmaier, C. Ortiz-de Solorzano, O. Demirel, Y. Li, I. Smal, N. Harder, K. Rohr, K. E. G. Magnusson, P. Xiao, and M. Radojevic, “An objective comparison of cell-tracking algorithms,” Nat. Methods 14, 1141–1152 (2017).
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Nat. Photonics (1)

Y. Park, C. Depeursinge, and G. Popescu, “Quantitative phase imaging in biomedicine,” Nat. Photonics 12, 578 (2018).
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Nature (2)

R. Barer, “Interference microscopy and mass determination,” Nature 169, 366 (1952).
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H. Davies and M. Wilkins, “Interference microscopy and mass determination,” Nature 169, 541 (1952).
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Opt. express (1)

Opt. letters (1)

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. letters 30, 468–470 (2005).
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Proc. Natl. Acad. Sci. (2)

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. 108, 13124–13129 (2011).
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K. Park, L. J. Millet, N. Kim, H. Li, X. Jin, G. Popescu, N. Aluru, K. J. Hsia, and R. Bashir, “Measurement of adherent cell mass and growth,” Proc. Natl. Acad. Sci. 107, 20691–20696 (2010).
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Prog. Opt. (1)

M. Mir, B. Bhaduri, R. Wang, R. Zhu, and G. Popescu, “Quantitative phase imaging,” Prog. Opt. 57, 133–217 (2012).
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Sci. reports (1)

M. Hejna, A. Jorapur, J. S. Song, and R. L. Judson, “High accuracy label-free classification of single-cell kinetic states from holographic cytometry of human melanoma cells,” Sci. reports 7, 11943 (2017).
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S. Monneret, P. Bon, G. Baffou, P. Berto, J. Savatier, S. Aknoun, and H. Rigneault, “Quadriwave lateral shearing interferometry as a quantification tool for microscopy. application to dry mass determination of living cells, temperature mapping, and vibrational phase imaging,” in Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, vol. 8792 (International Society for Optics and Photonics, 2013), p. 879209.
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Figures (8)

Fig. 1
Fig. 1 Optical setups a) LFM b) DHM c) LSI. LS light source, P pinhole, S sample, C camera, O microscope objective, BS beam splitter, R variable length reference arm, K Kohler illumination system, F band-pass filter, H modified Hartmann mask. Note that light source is partially coherent for LSI (Kohler illumination), and LFM (LED with a pinhole) and coherent (laser) for DHM (b). Modified Hartmann mask H and camera C in (c) compose the Phasics camera mounted on a standard wide-field microscope.
Fig. 2
Fig. 2 (a, b) OPD maps of the same fixed COS-7 cells obtained with the different techniques. Scale bar is 25 μm. (c) OPD profiles measured through the cell center in (b) (solid line: vertical, dashed line: horizontal).
Fig. 3
Fig. 3 Subtraction of the baseline image. (a) OPD raw map of a COS-7 cell (fixed) obtained by LSI(40×). (b) Estimation of the baseline image. (c) Final result after baseline subtraction, i.e. image(a)-image(b). Scale bar is 25 μm. (d, e, f) OPD profiles measured in the images (a, b, c) through the cell center (solid line: vertical, dashed line: horizontal). (g) The results of the baseline subtraction algorithm (black dots) are given by spatial variation measurements of the OPD values in sample-free area of 50×50 μm2. The different points correspond to different parameters used in the baseline subtraction algorithm. One black dot depicts the average value over several tens of OPD map. The measurements before baseline subtraction are plotted with red crosses.
Fig. 4
Fig. 4 Comparison between LSI(40×) and LFM. (a) OPD map of a fixed COS-7 cell obtained with LSI(40×). Scale bar is 25 μm. The contour of the ground truth cell segmentation area is shown in black. (b) OPD map obtained with LFM. (c) Pixel to pixel comparison between the OPD maps (within segmented cell area). The results of the linear regressions are indicated with values of slope, intercept, coefficient of determination (R2) and root-mean-square deviation (RMSD). (d) OVD obtained with LFM when introducing registration errors of ±1 μm on the X–Y position and ±0.5 degree on the rotation. The results are shown with and without the use of the best-matching algorithm, which counterbalances these errors. (e) Plot of the cell OVD measurements for different baseline subtraction algorithm parameters.
Fig. 5
Fig. 5 Pair-wise comparisons of OVD measurements of fixed COS-7 cells. The OVD measurements are obtained with the ground truth cell segmentation and the baseline subtraction algorithm parameters which minimize the spatial variation in the sample-free area. The linear regression fitting curves are plotted in black. The results of the linear regressions are indicated with values of slope, intercept, coefficient of determination (R2) and root-mean-square deviation (RMSD). N refers to the number of cell OVD measurements per comparison.
Fig. 6
Fig. 6 (a, b, c) OPD image of fixed COS-7 cells obtained with (a) LFM, (b) DHM(20×) and (c) LSI(40×). The 9 cells of interest are numbered. (d, e, f) OVD measured on the 9 cells of interest over 50 consecutive acquisitions with LFM, DHM(20×) and LSI(40×).
Fig. 7
Fig. 7 Estimations of the instrument precisions. (a) Results obtained with manual ground truth cell segmentation. The different point correspond to different parameters used in the baseline subtraction algorithm, i.e. the sensitivity of the adaptive thresholding filter (ranging from 0.5 to 1), two different OPD threshold values (ranging from 2.5 nm to 12.5 nm) and the order of the polynomial fitting of the OPD values in sample-free area (ranging from 3 to 10). The red crosses point out the results obtained with the baseline subtraction algorithm which minimizes the spatial variation in the sample-free area (see Fig. 3). The results of the optimized baseline subtraction algorithm are shown with red circles (see appendix A.2). (b) Results obtained with automatic cell segmentation. The different points correspond to different threshold values used in the seeded growing segmentation algorithm ranging between 5 nm and 17.5 nm. The red circles correspond to the results obtained with threshold values of 10 nm for LFM, 12.5 nm for DHM and 5 nm for LSI.
Fig. 8
Fig. 8 (a–c) Automatic seeded growing segmentation of a fixed COS-7 cell as a function of the threshold parameter value. The contour of the automatic segmentation and the manual ground truth are overlaid in orange and black, respectively. (d) Plot of the mean IoU (intersection over union) value and the mean ratio between the OVD measurements obtained with the automatic segmentation (OVDSEG) and the ground truth manual cell segmentation (OVDGT) as a function of the segmentation threshold value for the different modalities.

Tables (3)

Tables Icon

Table 1 Characteristics of the different optical setups used in this study.

Tables Icon

Table 2 Comparisons of the OVD measurements for fixed COS-7 cells.

Tables Icon

Table 3 Results of the estimation of the standard deviations σi of the noise terms i

Equations (21)

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φ shift ( x , y ) = φ ( x , y ) φ medium OPD ( x , y ) = λ φ shift ( x , y ) 2 π = 0 h [ n ( x , y , z ) n medium ] d z
OVD = S OPD ( x , y ) d x d y
CDM = OVD α
{ OVD k = α k + β k OVD T + k OVD l = α l + β l OVD T + l
OVD l = β l β k OVD k + ( α l β l β k α k ) + ( l β l β k k )
Var ( OVD l β l β k OVD k ) = Var ( l ) + ( β l β k ) 2 Var ( k )
𝒱 l , k = V l + S l , k 2 . V k
[ 1 S 1 , 2 2 0 0 0 1 0 S 1 , 3 2 0 0 1 0 0 S 1 , 4 2 0 1 0 0 0 S 1 , 5 2 0 1 S 2 , 3 2 0 0 0 1 0 S 2 , 4 2 0 0 1 0 0 S 2 , 5 2 0 0 1 S 3 , 4 2 0 0 0 1 0 S 3 , 5 2 0 0 0 1 S 4 , 5 2 ] [ V 1 V 2 V 3 V 4 V 5 ] = [ 𝒱 1 , 2 𝒱 1 , 3 𝒱 1 , 4 𝒱 1 , 5 𝒱 2 , 3 𝒱 2 , 4 𝒱 2 , 5 𝒱 3 , 4 𝒱 3 , 5 𝒱 4 , 5 ]
V = ( S T S ) 1 ( S T 𝒱 )
A 0 c ( r , λ , s ) = S c ( r , λ , s ) . T 0 ( r , λ )
A Z c ( r , λ , s ) = d r A 0 c ( r , λ , s ) . h Z ( r r , λ )
I Z p , c = d r d s d λ D p ( r , λ ) . | A Z c ( r , λ , s ) | 2
I Z p , c = W c ( r p ) . ( | A Z c | 2 * K c ) r p
I Z = W . ( | T 0 * h Z | 2 * K )
T 0 c ( r ) = A exp ( 2 i π L c ( r ) λ c )
( L ) = D ( L ) + α . O ( L )
D ( L ) = 4 N p . N c c d r ( M Z c ( r ) M Z c ¯ ( r ) ) 2
O ( L ) = d r ( c ε + ( ( L c ( r ) x ) 2 + ( L c ( r ) y ) 2 ) + ε + c ( L c ( r ) ) 2 + 10 . ( ε + c ( L c ( r ) < 0 ) . ( L c ( r ) ) 2 ) )
D c ( r ) = 16 π N p . N c Im ( ( ( ( ( W c . ( 1 M Z c ¯ M Z c ) ) * K c ) . A Z c ) * h Z c ) r . A 0 c ( r ) * )
O c ( r ) = x ( 1 e 1 ( r ) L c ( r ) x ) δ L c ( r ) y ( 1 e 1 ( r ) L c ( r ) y ) + L c ( r ) e 2 ( r ) + 10 . ( L c ( r ) < 0 ) . L c ( r )
δ = c d r c ( r ) . δ L c ( r )