Abstract

Brillouin micro-spectroscopy is applied for investigating the mechanical properties of bone and cartilage tissues of a human femoral head. Distinctive mechanical properties of the cartilage surface, subchondral and trabecular bone are reported, with marked heterogeneities at both micrometric and millimetric length scales. A ubiquitous soft component is reported for the first time, characterized by a longitudinal modulus of about 4.3 GPa, possibly related to the amorphous phase of the bone. This phase is mixed, at micrometric scales, with a harder component, ascribed to mineralized collagen fibrils, characterized by a longitudinal modulus ranging between 16 and 25 GPa.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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  18. S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
    [Crossref] [PubMed]
  19. I. M. Berke, J. P. Miola, M. A. David, M. K. Smith, and C. Price, “Seeing through Musculoskeletal Tissues: Improving In Situ Imaging of Bone and the Lacunar Canalicular System through Optical Clearing,” PLoS One 11(3), e0150268 (2016).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  21. D. Fioretto, S. Caponi, and F. Palombo, “Brillouin-Raman mapping of natural fibers with spectral moment analysis,” Biomed. Opt. Express 10(3), 1469–1476 (2019).
    [Crossref]
  22. R. B. Ashman and J. Y. Rho, “Elastic modulus of trabecular bone material,” J. Biomech. 21(3), 177–181 (1988).
    [Crossref] [PubMed]
  23. P. K. Zysset, X. E. Guo, C. E. Hoffler, K. E. Moore, and S. A. Goldstein, “Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur,” J. Biomech. 32(10), 1005–1012 (1999).
    [Crossref] [PubMed]
  24. Y. Chevalier, D. Pahr, H. Allmer, M. Charlebois, and P. Zysset, “Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation,” J. Biomech. 40(15), 3333–3340 (2007).
    [Crossref] [PubMed]

2019 (1)

2018 (2)

D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, and Z. N. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” J. Biomed. Opt. 23(9), 1–11 (2018).
[Crossref] [PubMed]

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref] [PubMed]

2017 (3)

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

H. P. Schwarcz, D. Abueidda, and I. Jasiuk, “The Ultrastructure of Bone and Its Relevance to Mechanical Properties,” Front. Phys. 5, 39 (2017).
[Crossref]

2016 (2)

O. A. Tertuliano and J. R. Greer, “The nanocomposite nature of bone drives its strength and damage resistance,” Nat. Mater. 15(11), 1195–1202 (2016).
[Crossref] [PubMed]

I. M. Berke, J. P. Miola, M. A. David, M. K. Smith, and C. Price, “Seeing through Musculoskeletal Tissues: Improving In Situ Imaging of Bone and the Lacunar Canalicular System through Optical Clearing,” PLoS One 11(3), e0150268 (2016).
[Crossref] [PubMed]

2014 (3)

M. Matsukawa, R. Tsubota, M. Kawabe, and K. Fukui, “Application of a micro-Brillouin scattering technique to characterize bone in the GHz range,” Ultrasonics 54(5), 1155–1161 (2014).
[Crossref] [PubMed]

N. Reznikov, R. Shahar, and S. Weiner, “Three-dimensional structure of human lamellar bone: the presence of two different materials and new insights into the hierarchical organization,” Bone 59, 93–104 (2014).
[Crossref] [PubMed]

N. Reznikov, R. Shahar, and S. Weiner, “Bone hierarchical structure in three dimensions,” Acta Biomater. 10(9), 3815–3826 (2014).
[Crossref] [PubMed]

2012 (2)

K. Fukui, S. Takayanagi, D. Suga, and M. Matsukawa, “Measurement of Wave Velocity in Cortical Bone by Micro-Brillouin Scattering Technique: Effect of Bone Tissue Properties,” Jpn. J. Appl. Phys. 51(7S), 07GF20 (2012).
[Crossref]

M. Kawabe, K. Fukui, M. Matsukawa, M. Granke, A. Saïed, Q. Grimal, and P. Laugier, “Comparative investigation of elastic properties in a trabecula using micro-Brillouin scattering and scanning acoustic microscopy,” J. Acoust. Soc. Am. 132(1), EL54–EL60 (2012).
[Crossref] [PubMed]

2011 (1)

D. Dallari, G. Pignatti, C. Stagni, G. Giavaresi, N. Del Piccolo, N. Rani, F. Veronesi, and M. Fini, “Total Hip Arthroplasty With Shortening Osteotomy in Congenital Major Hip Dislocation Sequelae,” Orthopedics 34(8), e328–e333 (2011).
[Crossref] [PubMed]

2009 (1)

A. J. Sophia Fox, A. Bedi, and S. A. Rodeo, “The Basic Science of Articular Cartilage: Structure, Composition, and Function,” Sports Health 1(6), 461–468 (2009).
[Crossref] [PubMed]

2007 (1)

Y. Chevalier, D. Pahr, H. Allmer, M. Charlebois, and P. Zysset, “Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation,” J. Biomech. 40(15), 3333–3340 (2007).
[Crossref] [PubMed]

2006 (1)

Y. Yamato, M. Matsukawa, T. Otani, K. Yamazaki, and A. Nagano, “Distribution of longitudinal wave properties in bovine cortical bone in vitro,” Ultrasonics 44(Suppl 1), e233–e237 (2006).
[Crossref] [PubMed]

1999 (3)

J.-Y. Rho, M. E. Roy, T. Y. Tsui, and G. M. Pharr, “Elastic properties of microstructural components of human bone tissue as measured by nanoindentation,” J. Biomed. Mater. Res. 45(1), 48–54 (1999).
[Crossref] [PubMed]

C. H. Turner, J. Rho, Y. Takano, T. Y. Tsui, and G. M. Pharr, “The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques,” J. Biomech. 32(4), 437–441 (1999).
[Crossref] [PubMed]

P. K. Zysset, X. E. Guo, C. E. Hoffler, K. E. Moore, and S. A. Goldstein, “Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur,” J. Biomech. 32(10), 1005–1012 (1999).
[Crossref] [PubMed]

1998 (1)

J.-Y. Rho, L. Kuhn-Spearing, and P. Zioupos, “Mechanical properties and the hierarchical structure of bone,” Med. Eng. Phys. 20(2), 92–102 (1998).
[Crossref] [PubMed]

1988 (1)

R. B. Ashman and J. Y. Rho, “Elastic modulus of trabecular bone material,” J. Biomech. 21(3), 177–181 (1988).
[Crossref] [PubMed]

1957 (1)

J. H. Kellgren and J. S. Lawrence, “Radiological Assessment of Osteo-Arthrosis,” Ann. Rheum. Dis. 16(4), 494–502 (1957).
[Crossref] [PubMed]

Abueidda, D.

H. P. Schwarcz, D. Abueidda, and I. Jasiuk, “The Ultrastructure of Bone and Its Relevance to Mechanical Properties,” Front. Phys. 5, 39 (2017).
[Crossref]

Akilbekova, D.

D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, and Z. N. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” J. Biomed. Opt. 23(9), 1–11 (2018).
[Crossref] [PubMed]

Allmer, H.

Y. Chevalier, D. Pahr, H. Allmer, M. Charlebois, and P. Zysset, “Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation,” J. Biomech. 40(15), 3333–3340 (2007).
[Crossref] [PubMed]

Ashman, R. B.

R. B. Ashman and J. Y. Rho, “Elastic modulus of trabecular bone material,” J. Biomech. 21(3), 177–181 (1988).
[Crossref] [PubMed]

Bedi, A.

A. J. Sophia Fox, A. Bedi, and S. A. Rodeo, “The Basic Science of Articular Cartilage: Structure, Composition, and Function,” Sports Health 1(6), 461–468 (2009).
[Crossref] [PubMed]

Berke, I. M.

I. M. Berke, J. P. Miola, M. A. David, M. K. Smith, and C. Price, “Seeing through Musculoskeletal Tissues: Improving In Situ Imaging of Bone and the Lacunar Canalicular System through Optical Clearing,” PLoS One 11(3), e0150268 (2016).
[Crossref] [PubMed]

Caponi, S.

D. Fioretto, S. Caponi, and F. Palombo, “Brillouin-Raman mapping of natural fibers with spectral moment analysis,” Biomed. Opt. Express 10(3), 1469–1476 (2019).
[Crossref]

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref] [PubMed]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Cardinali, G.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Charlebois, M.

Y. Chevalier, D. Pahr, H. Allmer, M. Charlebois, and P. Zysset, “Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation,” J. Biomech. 40(15), 3333–3340 (2007).
[Crossref] [PubMed]

Chevalier, Y.

Y. Chevalier, D. Pahr, H. Allmer, M. Charlebois, and P. Zysset, “Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation,” J. Biomech. 40(15), 3333–3340 (2007).
[Crossref] [PubMed]

Comez, L.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Corezzi, S.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Corte, L.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Dallari, D.

D. Dallari, G. Pignatti, C. Stagni, G. Giavaresi, N. Del Piccolo, N. Rani, F. Veronesi, and M. Fini, “Total Hip Arthroplasty With Shortening Osteotomy in Congenital Major Hip Dislocation Sequelae,” Orthopedics 34(8), e328–e333 (2011).
[Crossref] [PubMed]

David, M. A.

I. M. Berke, J. P. Miola, M. A. David, M. K. Smith, and C. Price, “Seeing through Musculoskeletal Tissues: Improving In Situ Imaging of Bone and the Lacunar Canalicular System through Optical Clearing,” PLoS One 11(3), e0150268 (2016).
[Crossref] [PubMed]

Del Piccolo, N.

D. Dallari, G. Pignatti, C. Stagni, G. Giavaresi, N. Del Piccolo, N. Rani, F. Veronesi, and M. Fini, “Total Hip Arthroplasty With Shortening Osteotomy in Congenital Major Hip Dislocation Sequelae,” Orthopedics 34(8), e328–e333 (2011).
[Crossref] [PubMed]

Di Girolamo, N.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Emiliani, C.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref] [PubMed]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Fini, M.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

D. Dallari, G. Pignatti, C. Stagni, G. Giavaresi, N. Del Piccolo, N. Rani, F. Veronesi, and M. Fini, “Total Hip Arthroplasty With Shortening Osteotomy in Congenital Major Hip Dislocation Sequelae,” Orthopedics 34(8), e328–e333 (2011).
[Crossref] [PubMed]

Fioretto, D.

D. Fioretto, S. Caponi, and F. Palombo, “Brillouin-Raman mapping of natural fibers with spectral moment analysis,” Biomed. Opt. Express 10(3), 1469–1476 (2019).
[Crossref]

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref] [PubMed]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Fukui, K.

M. Matsukawa, R. Tsubota, M. Kawabe, and K. Fukui, “Application of a micro-Brillouin scattering technique to characterize bone in the GHz range,” Ultrasonics 54(5), 1155–1161 (2014).
[Crossref] [PubMed]

K. Fukui, S. Takayanagi, D. Suga, and M. Matsukawa, “Measurement of Wave Velocity in Cortical Bone by Micro-Brillouin Scattering Technique: Effect of Bone Tissue Properties,” Jpn. J. Appl. Phys. 51(7S), 07GF20 (2012).
[Crossref]

M. Kawabe, K. Fukui, M. Matsukawa, M. Granke, A. Saïed, Q. Grimal, and P. Laugier, “Comparative investigation of elastic properties in a trabecula using micro-Brillouin scattering and scanning acoustic microscopy,” J. Acoust. Soc. Am. 132(1), EL54–EL60 (2012).
[Crossref] [PubMed]

Garbarino, V.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Giavaresi, G.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

D. Dallari, G. Pignatti, C. Stagni, G. Giavaresi, N. Del Piccolo, N. Rani, F. Veronesi, and M. Fini, “Total Hip Arthroplasty With Shortening Osteotomy in Congenital Major Hip Dislocation Sequelae,” Orthopedics 34(8), e328–e333 (2011).
[Crossref] [PubMed]

Goldstein, S. A.

P. K. Zysset, X. E. Guo, C. E. Hoffler, K. E. Moore, and S. A. Goldstein, “Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur,” J. Biomech. 32(10), 1005–1012 (1999).
[Crossref] [PubMed]

Granke, M.

M. Kawabe, K. Fukui, M. Matsukawa, M. Granke, A. Saïed, Q. Grimal, and P. Laugier, “Comparative investigation of elastic properties in a trabecula using micro-Brillouin scattering and scanning acoustic microscopy,” J. Acoust. Soc. Am. 132(1), EL54–EL60 (2012).
[Crossref] [PubMed]

Greer, J. R.

O. A. Tertuliano and J. R. Greer, “The nanocomposite nature of bone drives its strength and damage resistance,” Nat. Mater. 15(11), 1195–1202 (2016).
[Crossref] [PubMed]

Grimal, Q.

M. Kawabe, K. Fukui, M. Matsukawa, M. Granke, A. Saïed, Q. Grimal, and P. Laugier, “Comparative investigation of elastic properties in a trabecula using micro-Brillouin scattering and scanning acoustic microscopy,” J. Acoust. Soc. Am. 132(1), EL54–EL60 (2012).
[Crossref] [PubMed]

Guo, X. E.

P. K. Zysset, X. E. Guo, C. E. Hoffler, K. E. Moore, and S. A. Goldstein, “Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur,” J. Biomech. 32(10), 1005–1012 (1999).
[Crossref] [PubMed]

Hoffler, C. E.

P. K. Zysset, X. E. Guo, C. E. Hoffler, K. E. Moore, and S. A. Goldstein, “Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur,” J. Biomech. 32(10), 1005–1012 (1999).
[Crossref] [PubMed]

Ioannidu, C. A.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Jasiuk, I.

H. P. Schwarcz, D. Abueidda, and I. Jasiuk, “The Ultrastructure of Bone and Its Relevance to Mechanical Properties,” Front. Phys. 5, 39 (2017).
[Crossref]

Kawabe, M.

M. Matsukawa, R. Tsubota, M. Kawabe, and K. Fukui, “Application of a micro-Brillouin scattering technique to characterize bone in the GHz range,” Ultrasonics 54(5), 1155–1161 (2014).
[Crossref] [PubMed]

M. Kawabe, K. Fukui, M. Matsukawa, M. Granke, A. Saïed, Q. Grimal, and P. Laugier, “Comparative investigation of elastic properties in a trabecula using micro-Brillouin scattering and scanning acoustic microscopy,” J. Acoust. Soc. Am. 132(1), EL54–EL60 (2012).
[Crossref] [PubMed]

Kellgren, J. H.

J. H. Kellgren and J. S. Lawrence, “Radiological Assessment of Osteo-Arthrosis,” Ann. Rheum. Dis. 16(4), 494–502 (1957).
[Crossref] [PubMed]

Kuhn-Spearing, L.

J.-Y. Rho, L. Kuhn-Spearing, and P. Zioupos, “Mechanical properties and the hierarchical structure of bone,” Med. Eng. Phys. 20(2), 92–102 (1998).
[Crossref] [PubMed]

Laugier, P.

M. Kawabe, K. Fukui, M. Matsukawa, M. Granke, A. Saïed, Q. Grimal, and P. Laugier, “Comparative investigation of elastic properties in a trabecula using micro-Brillouin scattering and scanning acoustic microscopy,” J. Acoust. Soc. Am. 132(1), EL54–EL60 (2012).
[Crossref] [PubMed]

Lawrence, J. S.

J. H. Kellgren and J. S. Lawrence, “Radiological Assessment of Osteo-Arthrosis,” Ann. Rheum. Dis. 16(4), 494–502 (1957).
[Crossref] [PubMed]

Longo, G.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Matsukawa, M.

M. Matsukawa, R. Tsubota, M. Kawabe, and K. Fukui, “Application of a micro-Brillouin scattering technique to characterize bone in the GHz range,” Ultrasonics 54(5), 1155–1161 (2014).
[Crossref] [PubMed]

K. Fukui, S. Takayanagi, D. Suga, and M. Matsukawa, “Measurement of Wave Velocity in Cortical Bone by Micro-Brillouin Scattering Technique: Effect of Bone Tissue Properties,” Jpn. J. Appl. Phys. 51(7S), 07GF20 (2012).
[Crossref]

M. Kawabe, K. Fukui, M. Matsukawa, M. Granke, A. Saïed, Q. Grimal, and P. Laugier, “Comparative investigation of elastic properties in a trabecula using micro-Brillouin scattering and scanning acoustic microscopy,” J. Acoust. Soc. Am. 132(1), EL54–EL60 (2012).
[Crossref] [PubMed]

Y. Yamato, M. Matsukawa, T. Otani, K. Yamazaki, and A. Nagano, “Distribution of longitudinal wave properties in bovine cortical bone in vitro,” Ultrasonics 44(Suppl 1), e233–e237 (2006).
[Crossref] [PubMed]

Mattana, S.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref] [PubMed]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Mattarelli, M.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref] [PubMed]

Miola, J. P.

I. M. Berke, J. P. Miola, M. A. David, M. K. Smith, and C. Price, “Seeing through Musculoskeletal Tissues: Improving In Situ Imaging of Bone and the Lacunar Canalicular System through Optical Clearing,” PLoS One 11(3), e0150268 (2016).
[Crossref] [PubMed]

Misiano, C.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Moore, K. E.

P. K. Zysset, X. E. Guo, C. E. Hoffler, K. E. Moore, and S. A. Goldstein, “Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur,” J. Biomech. 32(10), 1005–1012 (1999).
[Crossref] [PubMed]

Morresi, A.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Nagano, A.

Y. Yamato, M. Matsukawa, T. Otani, K. Yamazaki, and A. Nagano, “Distribution of longitudinal wave properties in bovine cortical bone in vitro,” Ultrasonics 44(Suppl 1), e233–e237 (2006).
[Crossref] [PubMed]

Nurakhmetov, A.

D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, and Z. N. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” J. Biomed. Opt. 23(9), 1–11 (2018).
[Crossref] [PubMed]

Ogay, V.

D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, and Z. N. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” J. Biomed. Opt. 23(9), 1–11 (2018).
[Crossref] [PubMed]

Otani, T.

Y. Yamato, M. Matsukawa, T. Otani, K. Yamazaki, and A. Nagano, “Distribution of longitudinal wave properties in bovine cortical bone in vitro,” Ultrasonics 44(Suppl 1), e233–e237 (2006).
[Crossref] [PubMed]

Pahr, D.

Y. Chevalier, D. Pahr, H. Allmer, M. Charlebois, and P. Zysset, “Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation,” J. Biomech. 40(15), 3333–3340 (2007).
[Crossref] [PubMed]

Palattella, A.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Palombo, F.

D. Fioretto, S. Caponi, and F. Palombo, “Brillouin-Raman mapping of natural fibers with spectral moment analysis,” Biomed. Opt. Express 10(3), 1469–1476 (2019).
[Crossref]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Panzini, G.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Paolantoni, M.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Pharr, G. M.

J.-Y. Rho, M. E. Roy, T. Y. Tsui, and G. M. Pharr, “Elastic properties of microstructural components of human bone tissue as measured by nanoindentation,” J. Biomed. Mater. Res. 45(1), 48–54 (1999).
[Crossref] [PubMed]

C. H. Turner, J. Rho, Y. Takano, T. Y. Tsui, and G. M. Pharr, “The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques,” J. Biomech. 32(4), 437–441 (1999).
[Crossref] [PubMed]

Pignatti, G.

D. Dallari, G. Pignatti, C. Stagni, G. Giavaresi, N. Del Piccolo, N. Rani, F. Veronesi, and M. Fini, “Total Hip Arthroplasty With Shortening Osteotomy in Congenital Major Hip Dislocation Sequelae,” Orthopedics 34(8), e328–e333 (2011).
[Crossref] [PubMed]

Politi, L.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Price, C.

I. M. Berke, J. P. Miola, M. A. David, M. K. Smith, and C. Price, “Seeing through Musculoskeletal Tissues: Improving In Situ Imaging of Bone and the Lacunar Canalicular System through Optical Clearing,” PLoS One 11(3), e0150268 (2016).
[Crossref] [PubMed]

Rani, N.

D. Dallari, G. Pignatti, C. Stagni, G. Giavaresi, N. Del Piccolo, N. Rani, F. Veronesi, and M. Fini, “Total Hip Arthroplasty With Shortening Osteotomy in Congenital Major Hip Dislocation Sequelae,” Orthopedics 34(8), e328–e333 (2011).
[Crossref] [PubMed]

Reznikov, N.

N. Reznikov, R. Shahar, and S. Weiner, “Bone hierarchical structure in three dimensions,” Acta Biomater. 10(9), 3815–3826 (2014).
[Crossref] [PubMed]

N. Reznikov, R. Shahar, and S. Weiner, “Three-dimensional structure of human lamellar bone: the presence of two different materials and new insights into the hierarchical organization,” Bone 59, 93–104 (2014).
[Crossref] [PubMed]

Rho, J.

C. H. Turner, J. Rho, Y. Takano, T. Y. Tsui, and G. M. Pharr, “The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques,” J. Biomech. 32(4), 437–441 (1999).
[Crossref] [PubMed]

Rho, J. Y.

R. B. Ashman and J. Y. Rho, “Elastic modulus of trabecular bone material,” J. Biomech. 21(3), 177–181 (1988).
[Crossref] [PubMed]

Rho, J.-Y.

J.-Y. Rho, M. E. Roy, T. Y. Tsui, and G. M. Pharr, “Elastic properties of microstructural components of human bone tissue as measured by nanoindentation,” J. Biomed. Mater. Res. 45(1), 48–54 (1999).
[Crossref] [PubMed]

J.-Y. Rho, L. Kuhn-Spearing, and P. Zioupos, “Mechanical properties and the hierarchical structure of bone,” Med. Eng. Phys. 20(2), 92–102 (1998).
[Crossref] [PubMed]

Rodeo, S. A.

A. J. Sophia Fox, A. Bedi, and S. A. Rodeo, “The Basic Science of Articular Cartilage: Structure, Composition, and Function,” Sports Health 1(6), 461–468 (2009).
[Crossref] [PubMed]

Roscini, L.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Roy, M. E.

J.-Y. Rho, M. E. Roy, T. Y. Tsui, and G. M. Pharr, “Elastic properties of microstructural components of human bone tissue as measured by nanoindentation,” J. Biomed. Mater. Res. 45(1), 48–54 (1999).
[Crossref] [PubMed]

Sagini, K.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref] [PubMed]

Saïed, A.

M. Kawabe, K. Fukui, M. Matsukawa, M. Granke, A. Saïed, Q. Grimal, and P. Laugier, “Comparative investigation of elastic properties in a trabecula using micro-Brillouin scattering and scanning acoustic microscopy,” J. Acoust. Soc. Am. 132(1), EL54–EL60 (2012).
[Crossref] [PubMed]

Sandercock, J. R.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Sarsenova, M.

D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, and Z. N. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” J. Biomed. Opt. 23(9), 1–11 (2018).
[Crossref] [PubMed]

Sassi, P.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Scandurra, R.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Scarponi, F.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Schwarcz, H. P.

H. P. Schwarcz, D. Abueidda, and I. Jasiuk, “The Ultrastructure of Bone and Its Relevance to Mechanical Properties,” Front. Phys. 5, 39 (2017).
[Crossref]

Scotto d’Abusco, A.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Selleri, P.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Serra, M. D.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref] [PubMed]

Shahar, R.

N. Reznikov, R. Shahar, and S. Weiner, “Three-dimensional structure of human lamellar bone: the presence of two different materials and new insights into the hierarchical organization,” Bone 59, 93–104 (2014).
[Crossref] [PubMed]

N. Reznikov, R. Shahar, and S. Weiner, “Bone hierarchical structure in three dimensions,” Acta Biomater. 10(9), 3815–3826 (2014).
[Crossref] [PubMed]

Smith, M. K.

I. M. Berke, J. P. Miola, M. A. David, M. K. Smith, and C. Price, “Seeing through Musculoskeletal Tissues: Improving In Situ Imaging of Bone and the Lacunar Canalicular System through Optical Clearing,” PLoS One 11(3), e0150268 (2016).
[Crossref] [PubMed]

Sophia Fox, A. J.

A. J. Sophia Fox, A. Bedi, and S. A. Rodeo, “The Basic Science of Articular Cartilage: Structure, Composition, and Function,” Sports Health 1(6), 461–468 (2009).
[Crossref] [PubMed]

Stagni, C.

D. Dallari, G. Pignatti, C. Stagni, G. Giavaresi, N. Del Piccolo, N. Rani, F. Veronesi, and M. Fini, “Total Hip Arthroplasty With Shortening Osteotomy in Congenital Major Hip Dislocation Sequelae,” Orthopedics 34(8), e328–e333 (2011).
[Crossref] [PubMed]

Suga, D.

K. Fukui, S. Takayanagi, D. Suga, and M. Matsukawa, “Measurement of Wave Velocity in Cortical Bone by Micro-Brillouin Scattering Technique: Effect of Bone Tissue Properties,” Jpn. J. Appl. Phys. 51(7S), 07GF20 (2012).
[Crossref]

Superti, F.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Takano, Y.

C. H. Turner, J. Rho, Y. Takano, T. Y. Tsui, and G. M. Pharr, “The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques,” J. Biomech. 32(4), 437–441 (1999).
[Crossref] [PubMed]

Takayanagi, S.

K. Fukui, S. Takayanagi, D. Suga, and M. Matsukawa, “Measurement of Wave Velocity in Cortical Bone by Micro-Brillouin Scattering Technique: Effect of Bone Tissue Properties,” Jpn. J. Appl. Phys. 51(7S), 07GF20 (2012).
[Crossref]

Tazhin, K.

D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, and Z. N. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” J. Biomed. Opt. 23(9), 1–11 (2018).
[Crossref] [PubMed]

Tertuliano, O. A.

O. A. Tertuliano and J. R. Greer, “The nanocomposite nature of bone drives its strength and damage resistance,” Nat. Mater. 15(11), 1195–1202 (2016).
[Crossref] [PubMed]

Tsubota, R.

M. Matsukawa, R. Tsubota, M. Kawabe, and K. Fukui, “Application of a micro-Brillouin scattering technique to characterize bone in the GHz range,” Ultrasonics 54(5), 1155–1161 (2014).
[Crossref] [PubMed]

Tsui, T. Y.

C. H. Turner, J. Rho, Y. Takano, T. Y. Tsui, and G. M. Pharr, “The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques,” J. Biomech. 32(4), 437–441 (1999).
[Crossref] [PubMed]

J.-Y. Rho, M. E. Roy, T. Y. Tsui, and G. M. Pharr, “Elastic properties of microstructural components of human bone tissue as measured by nanoindentation,” J. Biomed. Mater. Res. 45(1), 48–54 (1999).
[Crossref] [PubMed]

Turner, C. H.

C. H. Turner, J. Rho, Y. Takano, T. Y. Tsui, and G. M. Pharr, “The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques,” J. Biomech. 32(4), 437–441 (1999).
[Crossref] [PubMed]

Umbayev, B.

D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, and Z. N. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” J. Biomed. Opt. 23(9), 1–11 (2018).
[Crossref] [PubMed]

Urbanelli, L.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref] [PubMed]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

Utegulov, Z. N.

D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, and Z. N. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” J. Biomed. Opt. 23(9), 1–11 (2018).
[Crossref] [PubMed]

Veronesi, F.

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

D. Dallari, G. Pignatti, C. Stagni, G. Giavaresi, N. Del Piccolo, N. Rani, F. Veronesi, and M. Fini, “Total Hip Arthroplasty With Shortening Osteotomy in Congenital Major Hip Dislocation Sequelae,” Orthopedics 34(8), e328–e333 (2011).
[Crossref] [PubMed]

Weiner, S.

N. Reznikov, R. Shahar, and S. Weiner, “Bone hierarchical structure in three dimensions,” Acta Biomater. 10(9), 3815–3826 (2014).
[Crossref] [PubMed]

N. Reznikov, R. Shahar, and S. Weiner, “Three-dimensional structure of human lamellar bone: the presence of two different materials and new insights into the hierarchical organization,” Bone 59, 93–104 (2014).
[Crossref] [PubMed]

Yakovlev, V. V.

D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, and Z. N. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” J. Biomed. Opt. 23(9), 1–11 (2018).
[Crossref] [PubMed]

Yakupov, T.

D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, and Z. N. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” J. Biomed. Opt. 23(9), 1–11 (2018).
[Crossref] [PubMed]

Yamato, Y.

Y. Yamato, M. Matsukawa, T. Otani, K. Yamazaki, and A. Nagano, “Distribution of longitudinal wave properties in bovine cortical bone in vitro,” Ultrasonics 44(Suppl 1), e233–e237 (2006).
[Crossref] [PubMed]

Yamazaki, K.

Y. Yamato, M. Matsukawa, T. Otani, K. Yamazaki, and A. Nagano, “Distribution of longitudinal wave properties in bovine cortical bone in vitro,” Ultrasonics 44(Suppl 1), e233–e237 (2006).
[Crossref] [PubMed]

Zioupos, P.

J.-Y. Rho, L. Kuhn-Spearing, and P. Zioupos, “Mechanical properties and the hierarchical structure of bone,” Med. Eng. Phys. 20(2), 92–102 (1998).
[Crossref] [PubMed]

Zysset, P.

Y. Chevalier, D. Pahr, H. Allmer, M. Charlebois, and P. Zysset, “Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation,” J. Biomech. 40(15), 3333–3340 (2007).
[Crossref] [PubMed]

Zysset, P. K.

P. K. Zysset, X. E. Guo, C. E. Hoffler, K. E. Moore, and S. A. Goldstein, “Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur,” J. Biomech. 32(10), 1005–1012 (1999).
[Crossref] [PubMed]

Acta Biomater. (1)

N. Reznikov, R. Shahar, and S. Weiner, “Bone hierarchical structure in three dimensions,” Acta Biomater. 10(9), 3815–3826 (2014).
[Crossref] [PubMed]

Ann. Rheum. Dis. (1)

J. H. Kellgren and J. S. Lawrence, “Radiological Assessment of Osteo-Arthrosis,” Ann. Rheum. Dis. 16(4), 494–502 (1957).
[Crossref] [PubMed]

Biomed. Opt. Express (1)

Bone (1)

N. Reznikov, R. Shahar, and S. Weiner, “Three-dimensional structure of human lamellar bone: the presence of two different materials and new insights into the hierarchical organization,” Bone 59, 93–104 (2014).
[Crossref] [PubMed]

Front. Phys. (1)

H. P. Schwarcz, D. Abueidda, and I. Jasiuk, “The Ultrastructure of Bone and Its Relevance to Mechanical Properties,” Front. Phys. 5, 39 (2017).
[Crossref]

J. Acoust. Soc. Am. (1)

M. Kawabe, K. Fukui, M. Matsukawa, M. Granke, A. Saïed, Q. Grimal, and P. Laugier, “Comparative investigation of elastic properties in a trabecula using micro-Brillouin scattering and scanning acoustic microscopy,” J. Acoust. Soc. Am. 132(1), EL54–EL60 (2012).
[Crossref] [PubMed]

J. Biomech. (4)

R. B. Ashman and J. Y. Rho, “Elastic modulus of trabecular bone material,” J. Biomech. 21(3), 177–181 (1988).
[Crossref] [PubMed]

P. K. Zysset, X. E. Guo, C. E. Hoffler, K. E. Moore, and S. A. Goldstein, “Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur,” J. Biomech. 32(10), 1005–1012 (1999).
[Crossref] [PubMed]

Y. Chevalier, D. Pahr, H. Allmer, M. Charlebois, and P. Zysset, “Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation,” J. Biomech. 40(15), 3333–3340 (2007).
[Crossref] [PubMed]

C. H. Turner, J. Rho, Y. Takano, T. Y. Tsui, and G. M. Pharr, “The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques,” J. Biomech. 32(4), 437–441 (1999).
[Crossref] [PubMed]

J. Biomed. Mater. Res. (1)

J.-Y. Rho, M. E. Roy, T. Y. Tsui, and G. M. Pharr, “Elastic properties of microstructural components of human bone tissue as measured by nanoindentation,” J. Biomed. Mater. Res. 45(1), 48–54 (1999).
[Crossref] [PubMed]

J. Biomed. Opt. (1)

D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, and Z. N. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” J. Biomed. Opt. 23(9), 1–11 (2018).
[Crossref] [PubMed]

Jpn. J. Appl. Phys. (1)

K. Fukui, S. Takayanagi, D. Suga, and M. Matsukawa, “Measurement of Wave Velocity in Cortical Bone by Micro-Brillouin Scattering Technique: Effect of Bone Tissue Properties,” Jpn. J. Appl. Phys. 51(7S), 07GF20 (2012).
[Crossref]

Light Sci. Appl. (1)

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref] [PubMed]

Mater. Sci. Eng. C (1)

F. Veronesi, G. Giavaresi, M. Fini, G. Longo, C. A. Ioannidu, A. Scotto d’Abusco, F. Superti, G. Panzini, C. Misiano, A. Palattella, P. Selleri, N. Di Girolamo, V. Garbarino, L. Politi, and R. Scandurra, “Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon,” Mater. Sci. Eng. C 70(Pt 1), 264–271 (2017).
[Crossref] [PubMed]

Med. Eng. Phys. (1)

J.-Y. Rho, L. Kuhn-Spearing, and P. Zioupos, “Mechanical properties and the hierarchical structure of bone,” Med. Eng. Phys. 20(2), 92–102 (1998).
[Crossref] [PubMed]

Nat. Mater. (1)

O. A. Tertuliano and J. R. Greer, “The nanocomposite nature of bone drives its strength and damage resistance,” Nat. Mater. 15(11), 1195–1202 (2016).
[Crossref] [PubMed]

Orthopedics (1)

D. Dallari, G. Pignatti, C. Stagni, G. Giavaresi, N. Del Piccolo, N. Rani, F. Veronesi, and M. Fini, “Total Hip Arthroplasty With Shortening Osteotomy in Congenital Major Hip Dislocation Sequelae,” Orthopedics 34(8), e328–e333 (2011).
[Crossref] [PubMed]

Phys. Rev. X (1)

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-Performance Versatile Setup for Simultaneous Brillouin-Raman Microspectroscopy,” Phys. Rev. X 7, 031015 (2017).

PLoS One (1)

I. M. Berke, J. P. Miola, M. A. David, M. K. Smith, and C. Price, “Seeing through Musculoskeletal Tissues: Improving In Situ Imaging of Bone and the Lacunar Canalicular System through Optical Clearing,” PLoS One 11(3), e0150268 (2016).
[Crossref] [PubMed]

Sports Health (1)

A. J. Sophia Fox, A. Bedi, and S. A. Rodeo, “The Basic Science of Articular Cartilage: Structure, Composition, and Function,” Sports Health 1(6), 461–468 (2009).
[Crossref] [PubMed]

Ultrasonics (2)

Y. Yamato, M. Matsukawa, T. Otani, K. Yamazaki, and A. Nagano, “Distribution of longitudinal wave properties in bovine cortical bone in vitro,” Ultrasonics 44(Suppl 1), e233–e237 (2006).
[Crossref] [PubMed]

M. Matsukawa, R. Tsubota, M. Kawabe, and K. Fukui, “Application of a micro-Brillouin scattering technique to characterize bone in the GHz range,” Ultrasonics 54(5), 1155–1161 (2014).
[Crossref] [PubMed]

Other (1)

N. Reznikov, M. Bilton, L. Lari, M. M. Stevens, and R. Kröger, “Fractal-like hierarchical organization of bone begins at the nanoscale,” Science 360, eaao2189 (2018).
[Crossref]

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Figures (2)

Fig. 1
Fig. 1 (a) 3D rendering image of a human femoral head with the site of inferomedial region from which the sample was selected. (b) Longitudinal section of the sample with subchondral bone (SB) and trabecular bone (TB). (c) Top view of the same section, showing the articular non-calcified cartilage surface (NCC). d) Typical Brillouin spectra collected from cartilage surface (blue), subchondral bone (red), and trabecular bone (black).
Fig. 2
Fig. 2 Left panel: distribution of the first spectral moments of Brillouin peaks in the articular cartilage surface (blue) subchondral bone (red), and trabecular bone (black). Frequency shifts of low frequency modes are reported in panels a), b) and c) and those of high frequency modes in panels d), e) and f). Right panel: frequency shifts of low frequency (υL) and high frequency (υH) modes collected from trabecular bone, showing an almost linear correlation, with r = 0,79.

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