Abstract

Optical detection of ultrasound is attractive to photoacoustic imaging due to its high sensitivity per unit area, broad bandwidth, and electromagnetic immunity. To enhance the sensitivity, previous optical transducers commonly necessitate bulk acoustic lenses to achieve focused ultrasound detection. Here, we proposed and demonstrated a novel lens-free focused optical ultrasound sensor by mechanically bending a flexible fiber laser. At a curvature radius of 30 mm, the curved fiber laser well conformed to the spherical wavefront of ultrasound exhibiting ~5 times higher sensitivity compared with the straight one. The focused fiber laser ultrasound sensor (FUS) presented a minimum detectable pressure of ~36 Pa with a working distance equal to its curvature radius. The sensor was applied to circular scanning photoacoustic computed tomography (PACT), which showed a ~70 μm in-plane resolution and a ~500 μm elevational resolution. In vivo imaging of a zebrafish and mouse brain shows the potential of this focused FUS for photoacoustic imaging in biological/medical studies.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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  1. J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,” Nat. Methods 13(1), 67–73 (2016).
    [Crossref] [PubMed]
  2. L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
    [Crossref] [PubMed]
  3. J. Aguirre, M. Schwarz, N. Garzorz, M. Omar, A. Buehler, K. Eyerich, and V. Ntziachristos, “Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy,” Nat. Bio. Eng. 1, 0068 (2017).
  4. A. Berezhnoi, M. Schwarz, A. Buehler, S. V. Ovsepian, J. Aguirre, and V. Ntziachristos, “Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy,” J. Biophotonics 11(11), e201700359 (2018).
    [Crossref] [PubMed]
  5. S. Hu and L. V. Wang, “Neurovascular Photoacoustic Tomography,” Front. Neuroenergetics 2, 10 (2010).
    [PubMed]
  6. J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage 64(1), 257–266 (2013).
    [Crossref] [PubMed]
  7. L. V. Wang and J. Yao, “A practical guide to photoacoustic tomography in the life sciences,” Nat. Methods 13(8), 627–638 (2016).
    [Crossref] [PubMed]
  8. K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, “Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries,” Opt. Lett. 33(9), 929–931 (2008).
    [Crossref] [PubMed]
  9. M. Jeon, J. Kim, and C. Kim, “Multiplane spectroscopic whole-body photoacoustic imaging of small animals in vivo,” Med. Biol. Eng. Comput. 54(2-3), 283–294 (2016).
    [Crossref] [PubMed]
  10. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
    [Crossref] [PubMed]
  11. P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, and L. V. Wang, “High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,” J. Biophotonics 11(1), e201700024 (2018).
    [Crossref] [PubMed]
  12. L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).
  13. R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
    [Crossref] [PubMed]
  14. B. Dong, C. Sun, and H. F. Zhang, “Optical detection of ultrasound in photoacoustic imaging,” IEEE Trans. Biomed. Eng. 64(1), 4–15 (2017).
    [Crossref] [PubMed]
  15. G. Wissmeyer, M. A. Pleitez, A. Rosenthal, and V. Ntziachristos, “Looking at sound: optoacoustics with all-optical ultrasound detection,” Light Sci. Appl. 7(1), 53 (2018).
    [Crossref] [PubMed]
  16. R. Nuster, P. Slezak, and G. Paltauf, “High resolution three-dimensional photoacoutic tomography with CCD-camera based ultrasound detection,” Biomed. Opt. Express 5(8), 2635–2647 (2014).
    [Crossref] [PubMed]
  17. A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
    [Crossref]
  18. J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
    [Crossref]
  19. G. Paltauf, R. Nuster, M. Haltmeier, and P. Burgholzer, “Photoacoustic tomography using a Mach-Zehnder interferometer as an acoustic line detector,” Appl. Opt. 46(16), 3352–3358 (2007).
    [Crossref] [PubMed]
  20. A. Rosenthal, D. Razansky, and V. Ntziachristos, “High-sensitivity compact ultrasonic detector based on a pi-phase-shifted fiber Bragg grating,” Opt. Lett. 36(10), 1833–1835 (2011).
    [Crossref] [PubMed]
  21. B. O. Guan, H. Y. Tam, S. T. Lau, and H. L. W. Chan, “Ultrasonic hydrophone based on distributed Bragg reflector fiber laser,” IEEE Photonics Technol. Lett. 17(1), 169–171 (2005).
    [Crossref]
  22. D. Gatti, G. Galzerano, D. Janner, S. Longhi, and P. Laporta, “Fiber strain sensor based on a π-phase-shifted Bragg grating and the Pound-Drever-Hall technique,” Opt. Express 16(3), 1945–1950 (2008).
    [Crossref] [PubMed]
  23. J. Eom, S. J. Park, and B. H. Lee, “Noncontact photoacoustic tomography of in vivo chicken chorioallantoic membrane based on all-fiber heterodyne interferometry,” J. Biomed. Opt. 20(10), 106007 (2015).
    [Crossref] [PubMed]
  24. A. Rosenthal, S. Kellnberger, D. Bozhko, A. Chekkoury, M. Omar, D. Razansky, and V. Ntziachristos, “Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications,” Laser Photonics Rev. 8(3), 450–457 (2014).
    [Crossref]
  25. Y. Liang, L. Jin, L. Wang, X. Bai, L. Cheng, and B. O. Guan, “Fiber-Laser-Based Ultrasound Sensor for Photoacoustic Imaging,” Sci. Rep. 7(1), 40849 (2017).
    [Crossref] [PubMed]
  26. Y. Liang, J. W. Liu, L. Jin, B. O. Guan, and L. Wang, “Fast-scanning photoacoustic microscopy with a side-looking fiber optic ultrasound sensor,” Biomed. Opt. Express 9(11), 5809–5816 (2018).
    [Crossref] [PubMed]
  27. X. Bai, Y. Liang, H. Sun, L. Jin, J. Ma, B. O. Guan, and L. Wang, “Sensitivity characteristics of broadband fiber-laser-based ultrasound sensors for photoacoustic microscopy,” Opt. Express 25(15), 17616–17626 (2017).
    [Crossref] [PubMed]
  28. J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express 17(13), 10489–10498 (2009).
    [Crossref] [PubMed]
  29. O. Ziemann, J. Krauser, P. E. Zamzow, and W. Daum, POF-polymer Optical Fibers for Data Communication (Springer Science & Business Media, 2002).
  30. T. Ishigure, Y. Aruga, and Y. Koike, “High-bandwidth PVDF-clad GI POF with ultra-low bending loss,” J. Lightwave Technol. 25(1), 335–345 (2007).
    [Crossref]
  31. J. Bauer-Marschallinger, A. Höllinger, B. Jakoby, P. Burgholzer, and T. Berer, “Fiber-optic annular detector array for large depth of field photoacoustic macroscopy,” Photoacoustics 5, 1–9 (2017).
    [Crossref] [PubMed]
  32. M. Xu and L. V. Wang, “Time-domain reconstruction for thermoacoustic tomography in a spherical geometry,” IEEE Trans. Med. Imaging 21(7), 814–822 (2002).
    [Crossref] [PubMed]
  33. L. Li, L. Zhu, Y. Shen, and L. V. Wang, “Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography,” J. Biomed. Opt. 22(7), 07617 (2017).
    [Crossref] [PubMed]
  34. G. Li, L. Li, L. Zhu, J. Xia, and L. V. Wang, “Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array,” J. Biomed. Opt. 20(6), 066010 (2015).
    [Crossref] [PubMed]

2018 (5)

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref] [PubMed]

A. Berezhnoi, M. Schwarz, A. Buehler, S. V. Ovsepian, J. Aguirre, and V. Ntziachristos, “Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy,” J. Biophotonics 11(11), e201700359 (2018).
[Crossref] [PubMed]

P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, and L. V. Wang, “High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,” J. Biophotonics 11(1), e201700024 (2018).
[Crossref] [PubMed]

G. Wissmeyer, M. A. Pleitez, A. Rosenthal, and V. Ntziachristos, “Looking at sound: optoacoustics with all-optical ultrasound detection,” Light Sci. Appl. 7(1), 53 (2018).
[Crossref] [PubMed]

Y. Liang, J. W. Liu, L. Jin, B. O. Guan, and L. Wang, “Fast-scanning photoacoustic microscopy with a side-looking fiber optic ultrasound sensor,” Biomed. Opt. Express 9(11), 5809–5816 (2018).
[Crossref] [PubMed]

2017 (8)

X. Bai, Y. Liang, H. Sun, L. Jin, J. Ma, B. O. Guan, and L. Wang, “Sensitivity characteristics of broadband fiber-laser-based ultrasound sensors for photoacoustic microscopy,” Opt. Express 25(15), 17616–17626 (2017).
[Crossref] [PubMed]

B. Dong, C. Sun, and H. F. Zhang, “Optical detection of ultrasound in photoacoustic imaging,” IEEE Trans. Biomed. Eng. 64(1), 4–15 (2017).
[Crossref] [PubMed]

L. Li, L. Zhu, Y. Shen, and L. V. Wang, “Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography,” J. Biomed. Opt. 22(7), 07617 (2017).
[Crossref] [PubMed]

J. Bauer-Marschallinger, A. Höllinger, B. Jakoby, P. Burgholzer, and T. Berer, “Fiber-optic annular detector array for large depth of field photoacoustic macroscopy,” Photoacoustics 5, 1–9 (2017).
[Crossref] [PubMed]

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

Y. Liang, L. Jin, L. Wang, X. Bai, L. Cheng, and B. O. Guan, “Fiber-Laser-Based Ultrasound Sensor for Photoacoustic Imaging,” Sci. Rep. 7(1), 40849 (2017).
[Crossref] [PubMed]

J. Aguirre, M. Schwarz, N. Garzorz, M. Omar, A. Buehler, K. Eyerich, and V. Ntziachristos, “Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy,” Nat. Bio. Eng. 1, 0068 (2017).

2016 (3)

J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,” Nat. Methods 13(1), 67–73 (2016).
[Crossref] [PubMed]

L. V. Wang and J. Yao, “A practical guide to photoacoustic tomography in the life sciences,” Nat. Methods 13(8), 627–638 (2016).
[Crossref] [PubMed]

M. Jeon, J. Kim, and C. Kim, “Multiplane spectroscopic whole-body photoacoustic imaging of small animals in vivo,” Med. Biol. Eng. Comput. 54(2-3), 283–294 (2016).
[Crossref] [PubMed]

2015 (3)

J. Eom, S. J. Park, and B. H. Lee, “Noncontact photoacoustic tomography of in vivo chicken chorioallantoic membrane based on all-fiber heterodyne interferometry,” J. Biomed. Opt. 20(10), 106007 (2015).
[Crossref] [PubMed]

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

G. Li, L. Li, L. Zhu, J. Xia, and L. V. Wang, “Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array,” J. Biomed. Opt. 20(6), 066010 (2015).
[Crossref] [PubMed]

2014 (2)

R. Nuster, P. Slezak, and G. Paltauf, “High resolution three-dimensional photoacoutic tomography with CCD-camera based ultrasound detection,” Biomed. Opt. Express 5(8), 2635–2647 (2014).
[Crossref] [PubMed]

A. Rosenthal, S. Kellnberger, D. Bozhko, A. Chekkoury, M. Omar, D. Razansky, and V. Ntziachristos, “Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications,” Laser Photonics Rev. 8(3), 450–457 (2014).
[Crossref]

2013 (1)

J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage 64(1), 257–266 (2013).
[Crossref] [PubMed]

2011 (1)

2010 (2)

S. Hu and L. V. Wang, “Neurovascular Photoacoustic Tomography,” Front. Neuroenergetics 2, 10 (2010).
[PubMed]

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[Crossref] [PubMed]

2009 (1)

2008 (2)

2007 (2)

2005 (1)

B. O. Guan, H. Y. Tam, S. T. Lau, and H. L. W. Chan, “Ultrasonic hydrophone based on distributed Bragg reflector fiber laser,” IEEE Photonics Technol. Lett. 17(1), 169–171 (2005).
[Crossref]

2003 (1)

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

2002 (1)

M. Xu and L. V. Wang, “Time-domain reconstruction for thermoacoustic tomography in a spherical geometry,” IEEE Trans. Med. Imaging 21(7), 814–822 (2002).
[Crossref] [PubMed]

Aguirre, A.

Aguirre, J.

A. Berezhnoi, M. Schwarz, A. Buehler, S. V. Ovsepian, J. Aguirre, and V. Ntziachristos, “Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy,” J. Biophotonics 11(11), e201700359 (2018).
[Crossref] [PubMed]

J. Aguirre, M. Schwarz, N. Garzorz, M. Omar, A. Buehler, K. Eyerich, and V. Ntziachristos, “Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy,” Nat. Bio. Eng. 1, 0068 (2017).

Allen, T. J.

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

Appleton, C. M.

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref] [PubMed]

Aruga, Y.

Bai, X.

Bauer-Marschallinger, J.

J. Bauer-Marschallinger, A. Höllinger, B. Jakoby, P. Burgholzer, and T. Berer, “Fiber-optic annular detector array for large depth of field photoacoustic macroscopy,” Photoacoustics 5, 1–9 (2017).
[Crossref] [PubMed]

Beard, P.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Beard, P. C.

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

Berer, T.

J. Bauer-Marschallinger, A. Höllinger, B. Jakoby, P. Burgholzer, and T. Berer, “Fiber-optic annular detector array for large depth of field photoacoustic macroscopy,” Photoacoustics 5, 1–9 (2017).
[Crossref] [PubMed]

Berezhnoi, A.

A. Berezhnoi, M. Schwarz, A. Buehler, S. V. Ovsepian, J. Aguirre, and V. Ntziachristos, “Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy,” J. Biophotonics 11(11), e201700359 (2018).
[Crossref] [PubMed]

Bozhko, D.

A. Rosenthal, S. Kellnberger, D. Bozhko, A. Chekkoury, M. Omar, D. Razansky, and V. Ntziachristos, “Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications,” Laser Photonics Rev. 8(3), 450–457 (2014).
[Crossref]

Buehler, A.

A. Berezhnoi, M. Schwarz, A. Buehler, S. V. Ovsepian, J. Aguirre, and V. Ntziachristos, “Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy,” J. Biophotonics 11(11), e201700359 (2018).
[Crossref] [PubMed]

J. Aguirre, M. Schwarz, N. Garzorz, M. Omar, A. Buehler, K. Eyerich, and V. Ntziachristos, “Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy,” Nat. Bio. Eng. 1, 0068 (2017).

Burgholzer, P.

J. Bauer-Marschallinger, A. Höllinger, B. Jakoby, P. Burgholzer, and T. Berer, “Fiber-optic annular detector array for large depth of field photoacoustic macroscopy,” Photoacoustics 5, 1–9 (2017).
[Crossref] [PubMed]

G. Paltauf, R. Nuster, M. Haltmeier, and P. Burgholzer, “Photoacoustic tomography using a Mach-Zehnder interferometer as an acoustic line detector,” Appl. Opt. 46(16), 3352–3358 (2007).
[Crossref] [PubMed]

Chan, H. L. W.

B. O. Guan, H. Y. Tam, S. T. Lau, and H. L. W. Chan, “Ultrasonic hydrophone based on distributed Bragg reflector fiber laser,” IEEE Photonics Technol. Lett. 17(1), 169–171 (2005).
[Crossref]

Chekkoury, A.

A. Rosenthal, S. Kellnberger, D. Bozhko, A. Chekkoury, M. Omar, D. Razansky, and V. Ntziachristos, “Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications,” Laser Photonics Rev. 8(3), 450–457 (2014).
[Crossref]

Chen, W.

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

Cheng, L.

Y. Liang, L. Jin, L. Wang, X. Bai, L. Cheng, and B. O. Guan, “Fiber-Laser-Based Ultrasound Sensor for Photoacoustic Imaging,” Sci. Rep. 7(1), 40849 (2017).
[Crossref] [PubMed]

Colchester, R. J.

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

Cox, B.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Del Rio, S. P.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[Crossref] [PubMed]

Demchenko, A. V.

J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage 64(1), 257–266 (2013).
[Crossref] [PubMed]

Desjardins, A. E.

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

Dong, B.

B. Dong, C. Sun, and H. F. Zhang, “Optical detection of ultrasound in photoacoustic imaging,” IEEE Trans. Biomed. Eng. 64(1), 4–15 (2017).
[Crossref] [PubMed]

Doyle, R. P.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[Crossref] [PubMed]

Eom, J.

J. Eom, S. J. Park, and B. H. Lee, “Noncontact photoacoustic tomography of in vivo chicken chorioallantoic membrane based on all-fiber heterodyne interferometry,” J. Biomed. Opt. 20(10), 106007 (2015).
[Crossref] [PubMed]

Eyerich, K.

J. Aguirre, M. Schwarz, N. Garzorz, M. Omar, A. Buehler, K. Eyerich, and V. Ntziachristos, “Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy,” Nat. Bio. Eng. 1, 0068 (2017).

Galzerano, G.

Gamelin, J.

Garzorz, N.

J. Aguirre, M. Schwarz, N. Garzorz, M. Omar, A. Buehler, K. Eyerich, and V. Ntziachristos, “Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy,” Nat. Bio. Eng. 1, 0068 (2017).

Gatti, D.

Guan, B. O.

Y. Liang, J. W. Liu, L. Jin, B. O. Guan, and L. Wang, “Fast-scanning photoacoustic microscopy with a side-looking fiber optic ultrasound sensor,” Biomed. Opt. Express 9(11), 5809–5816 (2018).
[Crossref] [PubMed]

X. Bai, Y. Liang, H. Sun, L. Jin, J. Ma, B. O. Guan, and L. Wang, “Sensitivity characteristics of broadband fiber-laser-based ultrasound sensors for photoacoustic microscopy,” Opt. Express 25(15), 17616–17626 (2017).
[Crossref] [PubMed]

Y. Liang, L. Jin, L. Wang, X. Bai, L. Cheng, and B. O. Guan, “Fiber-Laser-Based Ultrasound Sensor for Photoacoustic Imaging,” Sci. Rep. 7(1), 40849 (2017).
[Crossref] [PubMed]

B. O. Guan, H. Y. Tam, S. T. Lau, and H. L. W. Chan, “Ultrasonic hydrophone based on distributed Bragg reflector fiber laser,” IEEE Photonics Technol. Lett. 17(1), 169–171 (2005).
[Crossref]

Guggenheim, J. A.

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

Guo, P.

Haltmeier, M.

He, Y.

P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, and L. V. Wang, “High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,” J. Biophotonics 11(1), e201700024 (2018).
[Crossref] [PubMed]

Höllinger, A.

J. Bauer-Marschallinger, A. Höllinger, B. Jakoby, P. Burgholzer, and T. Berer, “Fiber-optic annular detector array for large depth of field photoacoustic macroscopy,” Photoacoustics 5, 1–9 (2017).
[Crossref] [PubMed]

Hu, P.

P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, and L. V. Wang, “High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,” J. Biophotonics 11(1), e201700024 (2018).
[Crossref] [PubMed]

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref] [PubMed]

Hu, S.

Huang, F.

Ishigure, T.

Jakoby, B.

J. Bauer-Marschallinger, A. Höllinger, B. Jakoby, P. Burgholzer, and T. Berer, “Fiber-optic annular detector array for large depth of field photoacoustic macroscopy,” Photoacoustics 5, 1–9 (2017).
[Crossref] [PubMed]

Janner, D.

Jathoul, A. P.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Jeon, M.

M. Jeon, J. Kim, and C. Kim, “Multiplane spectroscopic whole-body photoacoustic imaging of small animals in vivo,” Med. Biol. Eng. Comput. 54(2-3), 283–294 (2016).
[Crossref] [PubMed]

Jin, L.

Johnson, P.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Kaberniuk, A. A.

J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,” Nat. Methods 13(1), 67–73 (2016).
[Crossref] [PubMed]

Kellnberger, S.

A. Rosenthal, S. Kellnberger, D. Bozhko, A. Chekkoury, M. Omar, D. Razansky, and V. Ntziachristos, “Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications,” Laser Photonics Rev. 8(3), 450–457 (2014).
[Crossref]

Kim, C.

M. Jeon, J. Kim, and C. Kim, “Multiplane spectroscopic whole-body photoacoustic imaging of small animals in vivo,” Med. Biol. Eng. Comput. 54(2-3), 283–294 (2016).
[Crossref] [PubMed]

Kim, J.

M. Jeon, J. Kim, and C. Kim, “Multiplane spectroscopic whole-body photoacoustic imaging of small animals in vivo,” Med. Biol. Eng. Comput. 54(2-3), 283–294 (2016).
[Crossref] [PubMed]

Koike, Y.

Kruger, R. A.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[Crossref] [PubMed]

Ku, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Lam, R. B.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[Crossref] [PubMed]

Laporta, P.

Lau, S. T.

B. O. Guan, H. Y. Tam, S. T. Lau, and H. L. W. Chan, “Ultrasonic hydrophone based on distributed Bragg reflector fiber laser,” IEEE Photonics Technol. Lett. 17(1), 169–171 (2005).
[Crossref]

Laufer, J.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Lee, B. H.

J. Eom, S. J. Park, and B. H. Lee, “Noncontact photoacoustic tomography of in vivo chicken chorioallantoic membrane based on all-fiber heterodyne interferometry,” J. Biomed. Opt. 20(10), 106007 (2015).
[Crossref] [PubMed]

Li, G.

J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,” Nat. Methods 13(1), 67–73 (2016).
[Crossref] [PubMed]

G. Li, L. Li, L. Zhu, J. Xia, and L. V. Wang, “Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array,” J. Biomed. Opt. 20(6), 066010 (2015).
[Crossref] [PubMed]

Li, J.

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

Li, L.

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref] [PubMed]

P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, and L. V. Wang, “High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,” J. Biophotonics 11(1), e201700024 (2018).
[Crossref] [PubMed]

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

L. Li, L. Zhu, Y. Shen, and L. V. Wang, “Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography,” J. Biomed. Opt. 22(7), 07617 (2017).
[Crossref] [PubMed]

J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,” Nat. Methods 13(1), 67–73 (2016).
[Crossref] [PubMed]

G. Li, L. Li, L. Zhu, J. Xia, and L. V. Wang, “Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array,” J. Biomed. Opt. 20(6), 066010 (2015).
[Crossref] [PubMed]

Liang, Y.

Lin, L.

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref] [PubMed]

P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, and L. V. Wang, “High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,” J. Biophotonics 11(1), e201700024 (2018).
[Crossref] [PubMed]

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

Liu, J. W.

Longhi, S.

Lythgoe, M. F.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Ma, C.

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

Ma, J.

Marafioti, T.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Maslov, K.

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref] [PubMed]

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, “Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries,” Opt. Lett. 33(9), 929–931 (2008).
[Crossref] [PubMed]

Maslov, K. I.

J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage 64(1), 257–266 (2013).
[Crossref] [PubMed]

Maurudis, A.

Nasiriavanaki, M.

J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage 64(1), 257–266 (2013).
[Crossref] [PubMed]

Noimark, S.

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

Ntziachristos, V.

G. Wissmeyer, M. A. Pleitez, A. Rosenthal, and V. Ntziachristos, “Looking at sound: optoacoustics with all-optical ultrasound detection,” Light Sci. Appl. 7(1), 53 (2018).
[Crossref] [PubMed]

A. Berezhnoi, M. Schwarz, A. Buehler, S. V. Ovsepian, J. Aguirre, and V. Ntziachristos, “Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy,” J. Biophotonics 11(11), e201700359 (2018).
[Crossref] [PubMed]

J. Aguirre, M. Schwarz, N. Garzorz, M. Omar, A. Buehler, K. Eyerich, and V. Ntziachristos, “Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy,” Nat. Bio. Eng. 1, 0068 (2017).

A. Rosenthal, S. Kellnberger, D. Bozhko, A. Chekkoury, M. Omar, D. Razansky, and V. Ntziachristos, “Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications,” Laser Photonics Rev. 8(3), 450–457 (2014).
[Crossref]

A. Rosenthal, D. Razansky, and V. Ntziachristos, “High-sensitivity compact ultrasonic detector based on a pi-phase-shifted fiber Bragg grating,” Opt. Lett. 36(10), 1833–1835 (2011).
[Crossref] [PubMed]

Nuster, R.

Ogunlade, O.

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Omar, M.

J. Aguirre, M. Schwarz, N. Garzorz, M. Omar, A. Buehler, K. Eyerich, and V. Ntziachristos, “Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy,” Nat. Bio. Eng. 1, 0068 (2017).

A. Rosenthal, S. Kellnberger, D. Bozhko, A. Chekkoury, M. Omar, D. Razansky, and V. Ntziachristos, “Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications,” Laser Photonics Rev. 8(3), 450–457 (2014).
[Crossref]

Ovsepian, S. V.

A. Berezhnoi, M. Schwarz, A. Buehler, S. V. Ovsepian, J. Aguirre, and V. Ntziachristos, “Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy,” J. Biophotonics 11(11), e201700359 (2018).
[Crossref] [PubMed]

Paltauf, G.

Pang, Y.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Papakonstantinou, I.

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

Park, S. J.

J. Eom, S. J. Park, and B. H. Lee, “Noncontact photoacoustic tomography of in vivo chicken chorioallantoic membrane based on all-fiber heterodyne interferometry,” J. Biomed. Opt. 20(10), 106007 (2015).
[Crossref] [PubMed]

Parkin, I. P.

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

Pedley, R. B.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Philip, B.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Pizzey, A. R.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Pleitez, M. A.

G. Wissmeyer, M. A. Pleitez, A. Rosenthal, and V. Ntziachristos, “Looking at sound: optoacoustics with all-optical ultrasound detection,” Light Sci. Appl. 7(1), 53 (2018).
[Crossref] [PubMed]

Pule, M. A.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Razansky, D.

A. Rosenthal, S. Kellnberger, D. Bozhko, A. Chekkoury, M. Omar, D. Razansky, and V. Ntziachristos, “Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications,” Laser Photonics Rev. 8(3), 450–457 (2014).
[Crossref]

A. Rosenthal, D. Razansky, and V. Ntziachristos, “High-sensitivity compact ultrasonic detector based on a pi-phase-shifted fiber Bragg grating,” Opt. Lett. 36(10), 1833–1835 (2011).
[Crossref] [PubMed]

Reinecke, D. R.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[Crossref] [PubMed]

Rosenthal, A.

G. Wissmeyer, M. A. Pleitez, A. Rosenthal, and V. Ntziachristos, “Looking at sound: optoacoustics with all-optical ultrasound detection,” Light Sci. Appl. 7(1), 53 (2018).
[Crossref] [PubMed]

A. Rosenthal, S. Kellnberger, D. Bozhko, A. Chekkoury, M. Omar, D. Razansky, and V. Ntziachristos, “Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications,” Laser Photonics Rev. 8(3), 450–457 (2014).
[Crossref]

A. Rosenthal, D. Razansky, and V. Ntziachristos, “High-sensitivity compact ultrasonic detector based on a pi-phase-shifted fiber Bragg grating,” Opt. Lett. 36(10), 1833–1835 (2011).
[Crossref] [PubMed]

Schwarz, M.

A. Berezhnoi, M. Schwarz, A. Buehler, S. V. Ovsepian, J. Aguirre, and V. Ntziachristos, “Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy,” J. Biophotonics 11(11), e201700359 (2018).
[Crossref] [PubMed]

J. Aguirre, M. Schwarz, N. Garzorz, M. Omar, A. Buehler, K. Eyerich, and V. Ntziachristos, “Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy,” Nat. Bio. Eng. 1, 0068 (2017).

Shcherbakova, D. M.

J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,” Nat. Methods 13(1), 67–73 (2016).
[Crossref] [PubMed]

Shen, Y.

L. Li, L. Zhu, Y. Shen, and L. V. Wang, “Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography,” J. Biomed. Opt. 22(7), 07617 (2017).
[Crossref] [PubMed]

Shi, J.

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref] [PubMed]

P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, and L. V. Wang, “High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,” J. Biophotonics 11(1), e201700024 (2018).
[Crossref] [PubMed]

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

Slezak, P.

Stoica, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Sun, C.

B. Dong, C. Sun, and H. F. Zhang, “Optical detection of ultrasound in photoacoustic imaging,” IEEE Trans. Biomed. Eng. 64(1), 4–15 (2017).
[Crossref] [PubMed]

Sun, H.

Tam, H. Y.

B. O. Guan, H. Y. Tam, S. T. Lau, and H. L. W. Chan, “Ultrasonic hydrophone based on distributed Bragg reflector fiber laser,” IEEE Photonics Technol. Lett. 17(1), 169–171 (2005).
[Crossref]

Treeby, B.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Tsytsarev, V.

J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage 64(1), 257–266 (2013).
[Crossref] [PubMed]

Verkhusha, V. V.

J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,” Nat. Methods 13(1), 67–73 (2016).
[Crossref] [PubMed]

Wang, L.

Y. Liang, J. W. Liu, L. Jin, B. O. Guan, and L. Wang, “Fast-scanning photoacoustic microscopy with a side-looking fiber optic ultrasound sensor,” Biomed. Opt. Express 9(11), 5809–5816 (2018).
[Crossref] [PubMed]

X. Bai, Y. Liang, H. Sun, L. Jin, J. Ma, B. O. Guan, and L. Wang, “Sensitivity characteristics of broadband fiber-laser-based ultrasound sensors for photoacoustic microscopy,” Opt. Express 25(15), 17616–17626 (2017).
[Crossref] [PubMed]

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

Y. Liang, L. Jin, L. Wang, X. Bai, L. Cheng, and B. O. Guan, “Fiber-Laser-Based Ultrasound Sensor for Photoacoustic Imaging,” Sci. Rep. 7(1), 40849 (2017).
[Crossref] [PubMed]

J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,” Nat. Methods 13(1), 67–73 (2016).
[Crossref] [PubMed]

Wang, L. V.

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref] [PubMed]

P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, and L. V. Wang, “High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,” J. Biophotonics 11(1), e201700024 (2018).
[Crossref] [PubMed]

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

L. Li, L. Zhu, Y. Shen, and L. V. Wang, “Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography,” J. Biomed. Opt. 22(7), 07617 (2017).
[Crossref] [PubMed]

L. V. Wang and J. Yao, “A practical guide to photoacoustic tomography in the life sciences,” Nat. Methods 13(8), 627–638 (2016).
[Crossref] [PubMed]

J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,” Nat. Methods 13(1), 67–73 (2016).
[Crossref] [PubMed]

G. Li, L. Li, L. Zhu, J. Xia, and L. V. Wang, “Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array,” J. Biomed. Opt. 20(6), 066010 (2015).
[Crossref] [PubMed]

J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage 64(1), 257–266 (2013).
[Crossref] [PubMed]

S. Hu and L. V. Wang, “Neurovascular Photoacoustic Tomography,” Front. Neuroenergetics 2, 10 (2010).
[PubMed]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express 17(13), 10489–10498 (2009).
[Crossref] [PubMed]

K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, “Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries,” Opt. Lett. 33(9), 929–931 (2008).
[Crossref] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

M. Xu and L. V. Wang, “Time-domain reconstruction for thermoacoustic tomography in a spherical geometry,” IEEE Trans. Med. Imaging 21(7), 814–822 (2002).
[Crossref] [PubMed]

Wang, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Wissmeyer, G.

G. Wissmeyer, M. A. Pleitez, A. Rosenthal, and V. Ntziachristos, “Looking at sound: optoacoustics with all-optical ultrasound detection,” Light Sci. Appl. 7(1), 53 (2018).
[Crossref] [PubMed]

Xia, J.

G. Li, L. Li, L. Zhu, J. Xia, and L. V. Wang, “Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array,” J. Biomed. Opt. 20(6), 066010 (2015).
[Crossref] [PubMed]

J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage 64(1), 257–266 (2013).
[Crossref] [PubMed]

Xie, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Xu, M.

M. Xu and L. V. Wang, “Time-domain reconstruction for thermoacoustic tomography in a spherical geometry,” IEEE Trans. Med. Imaging 21(7), 814–822 (2002).
[Crossref] [PubMed]

Yao, J.

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

L. V. Wang and J. Yao, “A practical guide to photoacoustic tomography in the life sciences,” Nat. Methods 13(8), 627–638 (2016).
[Crossref] [PubMed]

J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,” Nat. Methods 13(1), 67–73 (2016).
[Crossref] [PubMed]

J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage 64(1), 257–266 (2013).
[Crossref] [PubMed]

Zhang, E.

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

Zhang, E. Z.

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

Zhang, H. F.

B. Dong, C. Sun, and H. F. Zhang, “Optical detection of ultrasound in photoacoustic imaging,” IEEE Trans. Biomed. Eng. 64(1), 4–15 (2017).
[Crossref] [PubMed]

K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, “Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries,” Opt. Lett. 33(9), 929–931 (2008).
[Crossref] [PubMed]

Zhang, P.

P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, and L. V. Wang, “High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,” J. Biophotonics 11(1), e201700024 (2018).
[Crossref] [PubMed]

Zhang, R.

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref] [PubMed]

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,” Nat. Methods 13(1), 67–73 (2016).
[Crossref] [PubMed]

Zhou, Y.

P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, and L. V. Wang, “High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,” J. Biophotonics 11(1), e201700024 (2018).
[Crossref] [PubMed]

Zhu, L.

P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, and L. V. Wang, “High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,” J. Biophotonics 11(1), e201700024 (2018).
[Crossref] [PubMed]

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

L. Li, L. Zhu, Y. Shen, and L. V. Wang, “Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography,” J. Biomed. Opt. 22(7), 07617 (2017).
[Crossref] [PubMed]

G. Li, L. Li, L. Zhu, J. Xia, and L. V. Wang, “Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array,” J. Biomed. Opt. 20(6), 066010 (2015).
[Crossref] [PubMed]

Zhu, Q.

Appl. Opt. (1)

Biomed. Opt. Express (2)

Front. Neuroenergetics (1)

S. Hu and L. V. Wang, “Neurovascular Photoacoustic Tomography,” Front. Neuroenergetics 2, 10 (2010).
[PubMed]

IEEE Photonics Technol. Lett. (1)

B. O. Guan, H. Y. Tam, S. T. Lau, and H. L. W. Chan, “Ultrasonic hydrophone based on distributed Bragg reflector fiber laser,” IEEE Photonics Technol. Lett. 17(1), 169–171 (2005).
[Crossref]

IEEE Trans. Biomed. Eng. (1)

B. Dong, C. Sun, and H. F. Zhang, “Optical detection of ultrasound in photoacoustic imaging,” IEEE Trans. Biomed. Eng. 64(1), 4–15 (2017).
[Crossref] [PubMed]

IEEE Trans. Med. Imaging (1)

M. Xu and L. V. Wang, “Time-domain reconstruction for thermoacoustic tomography in a spherical geometry,” IEEE Trans. Med. Imaging 21(7), 814–822 (2002).
[Crossref] [PubMed]

J. Biomed. Opt. (3)

L. Li, L. Zhu, Y. Shen, and L. V. Wang, “Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography,” J. Biomed. Opt. 22(7), 07617 (2017).
[Crossref] [PubMed]

G. Li, L. Li, L. Zhu, J. Xia, and L. V. Wang, “Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array,” J. Biomed. Opt. 20(6), 066010 (2015).
[Crossref] [PubMed]

J. Eom, S. J. Park, and B. H. Lee, “Noncontact photoacoustic tomography of in vivo chicken chorioallantoic membrane based on all-fiber heterodyne interferometry,” J. Biomed. Opt. 20(10), 106007 (2015).
[Crossref] [PubMed]

J. Biophotonics (2)

P. Zhang, L. Li, L. Lin, P. Hu, J. Shi, Y. He, L. Zhu, Y. Zhou, and L. V. Wang, “High-resolution deep functional imaging of the whole mouse brain by photoacoustic computed tomography in vivo,” J. Biophotonics 11(1), e201700024 (2018).
[Crossref] [PubMed]

A. Berezhnoi, M. Schwarz, A. Buehler, S. V. Ovsepian, J. Aguirre, and V. Ntziachristos, “Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy,” J. Biophotonics 11(11), e201700359 (2018).
[Crossref] [PubMed]

J. Lightwave Technol. (1)

Laser Photonics Rev. (1)

A. Rosenthal, S. Kellnberger, D. Bozhko, A. Chekkoury, M. Omar, D. Razansky, and V. Ntziachristos, “Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications,” Laser Photonics Rev. 8(3), 450–457 (2014).
[Crossref]

Light Sci. Appl. (1)

G. Wissmeyer, M. A. Pleitez, A. Rosenthal, and V. Ntziachristos, “Looking at sound: optoacoustics with all-optical ultrasound detection,” Light Sci. Appl. 7(1), 53 (2018).
[Crossref] [PubMed]

Med. Biol. Eng. Comput. (1)

M. Jeon, J. Kim, and C. Kim, “Multiplane spectroscopic whole-body photoacoustic imaging of small animals in vivo,” Med. Biol. Eng. Comput. 54(2-3), 283–294 (2016).
[Crossref] [PubMed]

Med. Phys. (1)

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[Crossref] [PubMed]

Nat. Bio. Eng. (1)

J. Aguirre, M. Schwarz, N. Garzorz, M. Omar, A. Buehler, K. Eyerich, and V. Ntziachristos, “Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy,” Nat. Bio. Eng. 1, 0068 (2017).

Nat. Biomed. Eng. (1)

L. Li, L. Zhu, C. Ma, L. Lin, J. Yao, L. Wang, K. Maslov, R. Zhang, W. Chen, J. Shi, and L. V. Wang, “Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution,” Nat. Biomed. Eng. 1(5), 0071 (2017).

Nat. Biotechnol. (1)

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Nat. Commun. (1)

L. Lin, P. Hu, J. Shi, C. M. Appleton, K. Maslov, L. Li, R. Zhang, and L. V. Wang, “Single-breath-hold photoacoustic computed tomography of the breast,” Nat. Commun. 9(1), 2352 (2018).
[Crossref] [PubMed]

Nat. Methods (2)

J. Yao, A. A. Kaberniuk, L. Li, D. M. Shcherbakova, R. Zhang, L. Wang, G. Li, V. V. Verkhusha, and L. V. Wang, “Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe,” Nat. Methods 13(1), 67–73 (2016).
[Crossref] [PubMed]

L. V. Wang and J. Yao, “A practical guide to photoacoustic tomography in the life sciences,” Nat. Methods 13(8), 627–638 (2016).
[Crossref] [PubMed]

Nat. Photonics (2)

A. P. Jathoul, J. Laufer, O. Ogunlade, B. Treeby, B. Cox, E. Zhang, P. Johnson, A. R. Pizzey, B. Philip, T. Marafioti, M. F. Lythgoe, R. B. Pedley, M. A. Pule, and P. Beard, “Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter,” Nat. Photonics 9(4), 239–246 (2015).
[Crossref]

J. A. Guggenheim, J. Li, T. J. Allen, R. J. Colchester, S. Noimark, O. Ogunlade, I. P. Parkin, I. Papakonstantinou, A. E. Desjardins, E. Z. Zhang, and P. C. Beard, “Ultrasensitive plano-concave optical microresonators for ultrasound sensing,” Nat. Photonics 11(11), 714–719 (2017).
[Crossref]

Neuroimage (1)

J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage 64(1), 257–266 (2013).
[Crossref] [PubMed]

Opt. Express (3)

Opt. Lett. (2)

Photoacoustics (1)

J. Bauer-Marschallinger, A. Höllinger, B. Jakoby, P. Burgholzer, and T. Berer, “Fiber-optic annular detector array for large depth of field photoacoustic macroscopy,” Photoacoustics 5, 1–9 (2017).
[Crossref] [PubMed]

Sci. Rep. (1)

Y. Liang, L. Jin, L. Wang, X. Bai, L. Cheng, and B. O. Guan, “Fiber-Laser-Based Ultrasound Sensor for Photoacoustic Imaging,” Sci. Rep. 7(1), 40849 (2017).
[Crossref] [PubMed]

Other (1)

O. Ziemann, J. Krauser, P. E. Zamzow, and W. Daum, POF-polymer Optical Fibers for Data Communication (Springer Science & Business Media, 2002).

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Figures (5)

Fig. 1
Fig. 1 (a) and (d): Schematic of a straight and a curved FUSs subjected to a point ultrasound source, respectively. The dashed lines plot the phase distribution of the ultrasound waves along the fiber. (b-c): Calculated spatial sensitivities of a straight FUS in x-z plane and x-y plane. (e-f) Calculated spatial sensitivities of a curved FUS in x-z plane and y-z plane.
Fig. 2
Fig. 2 (a) Schematic of ultrasound detection by using a curved fiber-laser sensor; (b) output laser spectrum; (c) beat frequency spectrum; (d) temporal response to an ultrasound pulse; (e) frequency responses to ultrasound sources in and out of focus, Norm. Am.: normalized amplitude.
Fig. 3
Fig. 3 (a) Measured acoustic responses of the straight and curved FUSs as a function of the distance along x axis, respectively; dots: measured results, curves: fit results. (b) Measured responses at curvatures of 20, 30 and 40 mm. (c-d) 2-D distribution of the ultrasound sensitivity in x-z plane and y-z plane, respectively.
Fig. 4
Fig. 4 (a) Schematic of a PACT system employing a curved FUS with a curvature radius of 30 mm; (b) the PA image of a phantom prepared by mixing black-dyed microspheres into agar (up) and the PA amplitude profile along the dashed line (bottom); (c) the normalized PA amplitude profile across a single 10 μm-diameter microsphere (the scale bar is 50 μm); (d) the normalized PA amplitude profiles across a human hair along z axis at different x locations (the inset figure summarizes the elevational resolutions at different x locations); (e) and (f) are the reconstructed images of a hair-cross with a straight (left) and a curved (right) FUSs, respectively.
Fig. 5
Fig. 5 In vivo images of (a) a zebrafish and (b) a mouse brain obtained by the FUS based PACT system. (c) and (d) are the unipolar images of (a) and (b), respectively, obtained by performing Hilbert transformation. SB: swim bladder, SC: spinal cord, AF: anal fin, CV: cortical vessels, SSS: superior sagittal sinus, ICV: inferior cerebral vein.

Equations (1)

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R u = Γ p 0 A(ω) L exp(i k a r) r dL

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