Abstract

A review on the technological development of en face optical coherence tomography (OCT) and optical coherence microscopy (OCM) is provided. The terminology originally referred to time domain OCT, where the preferential scanning was performed in the en face plane. Potentially the fastest realization of en face image recording is full-field OCT, where the full en face plane is illuminated and recorded simultaneously. The term has nowadays been adopted for high-speed Fourier domain approaches, where the en face image is reconstructed from full 3D volumes either by direct slicing or through axial projection in post processing. The success of modern en face OCT lies in its immediate and easy image interpretation, which is in particular of advantage for OCM or OCT angiography. Applications of en face OCT with a focus on ophthalmology are presented. The review concludes by outlining exciting technological prospects of en face OCT based both on time as well as on Fourier domain OCT.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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2018 (8)

R. Poddar and J. S. Werner, “Implementations of three OCT angiography (OCTA) methods with 1.7 MHz A-scan rate OCT system on imaging of human retinal and choroidal vasculature,” Opt. Laser Technol. 102, 130–139 (2018).
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R. A. Leitgeb and B. Baumann, “Multimodal optical medical imaging concepts based on optical coherence tomography,” Front. Phys. 6, 114 (2018).
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L. Ginner, T. Schmoll, A. Kumar, M. Salas, N. Pricoupenko, L. M. Wurster, and R. A. Leitgeb, “Holographic line field en-face OCT with digital adaptive optics in the retina in vivo,” Biomed. Opt. Express 9(2), 472–485 (2018).
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V. Mazlin, P. Xiao, E. Dalimier, K. Grieve, K. Irsch, J.-A. Sahel, M. Fink, and A. C. Boccara, “In vivo high resolution human corneal imaging using full-field optical coherence tomography,” Biomed. Opt. Express 9(2), 557–568 (2018).
[Crossref] [PubMed]

M. Salas, M. Augustin, F. Felberer, A. Wartak, M. Laslandes, L. Ginner, M. Niederleithner, J. Ensher, M. P. Minneman, R. A. Leitgeb, W. Drexler, X. Levecq, U. Schmidt-Erfurth, and M. Pircher, “Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye,” Biomed. Opt. Express 9(4), 1871–1892 (2018).
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P. Xiao, V. Mazlin, K. Grieve, J.-A. Sahel, M. Fink, and A. C. Boccara, “In vivo high-resolution human retinal imaging with wavefront-correctionless full-field OCT,” Optica 5(4), 409–412 (2018).
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H. Spahr, C. Pfäffle, P. Koch, H. Sudkamp, G. Hüttmann, and D. Hillmann, “Interferometric detection of 3D motion using computational subapertures in optical coherence tomography,” Opt. Express 26(15), 18803–18816 (2018).
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A. A. Grebenyuk, L. Ginner, and R. A. Leitgeb, “Numerically focused full-field swept-source optical coherence microscopy with structured illumination,” Opt. Express 26(26), 33772–33782 (2018).
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2017 (11)

L. Yi, L. Sun, and W. Ding, “Multifocal spectral-domain optical coherence tomography based on Bessel beam for extended imaging depth,” J. Biomed. Opt. 22(10), 1–8 (2017).
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O. Thouvenin, C. Boccara, M. Fink, J. Sahel, M. Pâques, and K. Grieve, “Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 58(11), 4605–4615 (2017).
[Crossref] [PubMed]

T. Klein and R. Huber, “High-speed OCT light sources and systems [Invited],” Biomed. Opt. Express 8(2), 828–859 (2017).
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C.-H. Liu, A. Schill, R. Raghunathan, C. Wu, M. Singh, Z. Han, A. Nair, and K. V. Larin, “Ultra-fast line-field low coherence holographic elastography using spatial phase shifting,” Biomed. Opt. Express 8(2), 993–1004 (2017).
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C.-L. Chen and R. K. Wang, “Optical coherence tomography based angiography [Invited],” Biomed. Opt. Express 8(2), 1056–1082 (2017).
[Crossref] [PubMed]

O. M. Carrasco-Zevallos, C. Viehland, B. Keller, M. Draelos, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Review of intraoperative optical coherence tomography: technology and applications [Invited],” Biomed. Opt. Express 8(3), 1607–1637 (2017).
[Crossref] [PubMed]

J. F. de Boer, C. K. Hitzenberger, and Y. Yasuno, “Polarization sensitive optical coherence tomography - a review [Invited],” Biomed. Opt. Express 8(3), 1838–1873 (2017).
[Crossref] [PubMed]

M. Pircher and R. J. Zawadzki, “Review of adaptive optics OCT (AO-OCT): principles and applications for retinal imaging [Invited],” Biomed. Opt. Express 8(5), 2536–2562 (2017).
[Crossref] [PubMed]

J. F. de Boer, R. Leitgeb, and M. Wojtkowski, “Twenty-five years of optical coherence tomography: the paradigm shift in sensitivity and speed provided by Fourier domain OCT [Invited],” Biomed. Opt. Express 8(7), 3248–3280 (2017).
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L. Ginner, A. Kumar, D. Fechtig, L. M. Wurster, M. Salas, M. Pircher, and R. A. Leitgeb, “Noniterative digital aberration correction for cellular resolution retinal optical coherence tomography in vivo,” Optica 4(8), 924–931 (2017).
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D. Hillmann, H. Spahr, H. Sudkamp, C. Hain, L. Hinkel, G. Franke, and G. Hüttmann, “Off-axis reference beam for full-field swept-source OCT and holoscopy,” Opt. Express 25(22), 27770–27784 (2017).
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2016 (10)

S. Rivet, M. Maria, A. Bradu, T. Feuchter, L. Leick, and A. Podoleanu, “Complex master slave interferometry,” Opt. Express 24(3), 2885–2904 (2016).
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C. Apelian, F. Harms, O. Thouvenin, and A. C. Boccara, “Dynamic full field optical coherence tomography: subcellular metabolic contrast revealed in tissues by interferometric signals temporal analysis,” Biomed. Opt. Express 7(4), 1511–1524 (2016).
[Crossref] [PubMed]

Z. Chen, M. Liu, M. Minneman, L. Ginner, E. Hoover, H. Sattmann, M. Bonesi, W. Drexler, and R. A. Leitgeb, “Phase-stable swept source OCT angiography in human skin using an akinetic source,” Biomed. Opt. Express 7(8), 3032–3048 (2016).
[Crossref] [PubMed]

C. Chin, A. Bradu, R. Lim, M. Khandwala, J. Schofield, L. Leick, and A. Podoleanu, “Master/slave optical coherence tomography imaging of eyelid basal cell carcinoma,” Appl. Opt. 55(26), 7378–7386 (2016).
[Crossref] [PubMed]

M. Salas, M. Augustin, L. Ginner, A. Kumar, B. Baumann, R. Leitgeb, W. Drexler, S. Prager, J. Hafner, U. Schmidt-Erfurth, and M. Pircher, “Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics,” Biomed. Opt. Express 8(1), 207–222 (2016).
[Crossref] [PubMed]

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: visualizing blood flow speeds in ocular pathology using variable interscan time analysis,” Retina 36(Suppl 1), S118–S126 (2016).
[Crossref] [PubMed]

A. Curatolo, P. R. T. Munro, D. Lorenser, P. Sreekumar, C. C. Singe, B. F. Kennedy, and D. D. Sampson, “Quantifying the influence of Bessel beams on image quality in optical coherence tomography,” Sci. Rep. 6(1), 23483 (2016).
[Crossref] [PubMed]

A. Badon, D. Li, G. Lerosey, A. C. Boccara, M. Fink, and A. Aubry, “Smart optical coherence tomography for ultra-deep imaging through highly scattering media,” Sci. Adv. 2(11), e1600370 (2016).
[Crossref] [PubMed]

R. S. Jonnal, O. P. Kocaoglu, R. J. Zawadzki, Z. Liu, D. T. Miller, and J. S. Werner, “A review of adaptive optics optical coherence tomography: Technical advances, scientific applications, and the future,” Invest. Ophthalmol. Vis. Sci. 57(9), OCT51–OCT68 (2016).
[Crossref] [PubMed]

D. Hillmann, H. Spahr, C. Hain, H. Sudkamp, G. Franke, C. Pfäffle, C. Winter, and G. Hüttmann, “Aberration-free volumetric high-speed imaging of in vivo retina,” Sci. Rep. 6(1), 35209 (2016).
[Crossref] [PubMed]

2015 (9)

N. D. Shemonski, F. A. South, Y.-Z. Liu, S. G. Adie, P. S. Carney, and S. A. Boppart, “Computational high-resolution optical imaging of the living human retina,” Nat. Photonics 9(7), 440–443 (2015).
[Crossref] [PubMed]

J. Wang, A. Bradu, G. Dobre, and A. Podoleanu, “Full-Field Swept Source Master-Slave Optical Coherence Tomography,” IEEE Photonics J. 7, 1–14 (2015).
[Crossref]

R. F. Spaide, J. G. Fujimoto, and N. K. Waheed, “Image artifacts in optical coherence tomography angiography,” Retina 35(11), 2163–2180 (2015).
[Crossref] [PubMed]

X. Yao and B. Wang, “Intrinsic optical signal imaging of retinal physiology: a review,” J. Biomed. Opt. 20(9), 090901 (2015).
[Crossref] [PubMed]

M. Sugita, M. Pircher, S. Zotter, B. Baumann, P. Roberts, T. Makihira, N. Tomatsu, M. Sato, C. Vass, and C. K. Hitzenberger, “Retinal nerve fiber bundle tracing and analysis in human eye by polarization sensitive OCT,” Biomed. Opt. Express 6(3), 1030–1054 (2015).
[Crossref] [PubMed]

A. Kumar, T. Kamali, R. Platzer, A. Unterhuber, W. Drexler, and R. A. Leitgeb, “Anisotropic aberration correction using region of interest based digital adaptive optics in Fourier domain OCT,” Biomed. Opt. Express 6(4), 1124–1134 (2015).
[Crossref] [PubMed]

A. Bradu, M. Maria, and A. G. Podoleanu, “Demonstration of tolerance to dispersion of master/slave interferometry,” Opt. Express 23(11), 14148–14161 (2015).
[Crossref] [PubMed]

N. Lippok, M. Villiger, and B. E. Bouma, “Degree of polarization (uniformity) and depolarization index: unambiguous depolarization contrast for optical coherence tomography,” Opt. Lett. 40(17), 3954–3957 (2015).
[Crossref] [PubMed]

A. Bradu, K. Kapinchev, F. Barnes, and A. Podoleanu, “Master slave en-face OCT/SLO,” Biomed. Opt. Express 6(9), 3655–3669 (2015).
[Crossref] [PubMed]

2014 (11)

F. Felberer, J. S. Kroisamer, B. Baumann, S. Zotter, U. Schmidt-Erfurth, C. K. Hitzenberger, and M. Pircher, “Adaptive optics SLO/OCT for 3D imaging of human photoreceptors in vivo,” Biomed. Opt. Express 5(2), 439–456 (2014).
[Crossref] [PubMed]

A. Bradu and A. G. Podoleanu, “Calibration-free B-scan images produced by master/slave optical coherence tomography,” Opt. Lett. 39(3), 450–453 (2014).
[Crossref] [PubMed]

M. Bonesi, M. P. Minneman, J. Ensher, B. Zabihian, H. Sattmann, P. Boschert, E. Hoover, R. A. Leitgeb, M. Crawford, and W. Drexler, “Akinetic all-semiconductor programmable swept-source at 1550 nm and 1310 nm with centimeters coherence length,” Opt. Express 22(3), 2632–2655 (2014).
[Crossref] [PubMed]

A. Grebenyuk, A. Federici, V. Ryabukho, and A. Dubois, “Numerically focused full-field swept-source optical coherence microscopy with low spatial coherence illumination,” Appl. Opt. 53(8), 1697–1708 (2014).
[Crossref] [PubMed]

A. Bradu and A. G. Podoleanu, “Imaging the eye fundus with real-time en-face spectral domain optical coherence tomography,” Biomed. Opt. Express 5(4), 1233–1249 (2014).
[Crossref] [PubMed]

D. J. Fechtig, T. Schmoll, B. Grajciar, W. Drexler, and R. A. Leitgeb, “Line-field parallel swept source interferometric imaging at up to 1 MHz,” Opt. Lett. 39(18), 5333–5336 (2014).
[Crossref] [PubMed]

O. P. Kocaoglu, T. L. Turner, Z. Liu, and D. T. Miller, “Adaptive optics optical coherence tomography at 1 MHz,” Biomed. Opt. Express 5(12), 4186–4200 (2014).
[Crossref] [PubMed]

S. Makita, Y. J. Hong, M. Miura, and Y. Yasuno, “Degree of polarization uniformity with high noise immunity using polarization-sensitive optical coherence tomography,” Opt. Lett. 39(24), 6783–6786 (2014).
[Crossref] [PubMed]

O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large field, high resolution full-field optical coherence tomography: a pre-clinical study of human breast tissue and cancer assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
[PubMed]

D. J. Fechtig, A. Kumar, W. Drexler, and R. A. Leitgeb, “Full range line-field parallel swept source imaging utilizing digital refocusing,” J. Mod. Opt. 62, 1–7 (2014).

R. A. Leitgeb, R. M. Werkmeister, C. Blatter, and L. Schmetterer, “Doppler optical coherence tomography,” Prog. Retin. Eye Res. 41, 26–43 (2014).
[Crossref] [PubMed]

2013 (4)

2012 (5)

2011 (3)

2010 (7)

J. P. Rolland, P. Meemon, S. Murali, K. P. Thompson, and K. S. Lee, “Gabor-based fusion technique for Optical Coherence Microscopy,” Opt. Express 18(4), 3632–3642 (2010).
[Crossref] [PubMed]

M. Pircher, E. Götzinger, H. Sattmann, R. A. Leitgeb, and C. K. Hitzenberger, “In vivo investigation of human cone photoreceptors with SLO/OCT in combination with 3D motion correction on a cellular level,” Opt. Express 18(13), 13935–13944 (2010).
[Crossref] [PubMed]

A. S. G. Singh, C. Kolbitsch, T. Schmoll, and R. A. Leitgeb, “Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans,” Biomed. Opt. Express 1(4), 1047–1058 (2010).
[Crossref] [PubMed]

T. Bonin, G. Franke, M. Hagen-Eggert, P. Koch, and G. Hüttmann, “In vivo Fourier-domain full-field OCT of the human retina with 1.5 million A-lines/s,” Opt. Lett. 35(20), 3432–3434 (2010).
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S. M. Popoff, G. Lerosey, R. Carminati, M. Fink, A. C. Boccara, and S. Gigan, “Measuring the transmission matrix in optics: an approach to the study and control of light propagation in disordered media,” Phys. Rev. Lett. 104(10), 100601 (2010).
[Crossref] [PubMed]

C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
[Crossref] [PubMed]

T. Schmoll, C. Kolbitsch, and R. A. Leitgeb, “In vivo functional retinal optical coherence tomography,” J. Biomed. Opt. 15(4), 041513 (2010).
[Crossref] [PubMed]

2009 (2)

2008 (8)

M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner, and C. K. Hitzenberger, “Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography,” Opt. Lett. 33(1), 22–24 (2008).
[Crossref] [PubMed]

M. Yamanari, S. Makita, and Y. Yasuno, “Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation,” Opt. Express 16(8), 5892–5906 (2008).
[Crossref] [PubMed]

C. M. Eigenwillig, B. R. Biedermann, G. Palte, and R. Huber, “K-space linear Fourier domain mode locked laser and applications for optical coherence tomography,” Opt. Express 16(12), 8916–8937 (2008).
[Crossref] [PubMed]

K. S. Lee and J. P. Rolland, “Bessel beam spectral-domain high-resolution optical coherence tomography with micro-optic axicon providing extended focusing range,” Opt. Lett. 33(15), 1696–1698 (2008).
[Crossref] [PubMed]

B. R. Biedermann, W. Wieser, C. M. Eigenwillig, G. Palte, D. C. Adler, V. J. Srinivasan, J. G. Fujimoto, and R. Huber, “Real time en face Fourier-domain optical coherence tomography with direct hardware frequency demodulation,” Opt. Lett. 33(21), 2556–2558 (2008).
[Crossref] [PubMed]

S. Michels, M. Pircher, W. Geitzenauer, C. Simader, E. Götzinger, O. Findl, U. Schmidt-Erfurth, and C. K. Hitzenberger, “Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium,” Br. J. Ophthalmol. 92(2), 204–209 (2008).
[Crossref] [PubMed]

V. J. Srinivasan, D. C. Adler, Y. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head,” Invest. Ophthalmol. Vis. Sci. 49(11), 5103–5110 (2008).
[Crossref] [PubMed]

A. G. Podoleanu and R. B. Rosen, “Combinations of techniques in imaging the retina with high resolution,” Prog. Retin. Eye Res. 27(4), 464–499 (2008).
[Crossref] [PubMed]

2007 (9)

W. Drexler, J. G. Fujimoto, and Special Section Guest Editors, “Optical coherence tomography in ophthalmology,” J. Biomed. Opt. 12(4), 041201 (2007).
[Crossref]

M. Pircher and R. J. Zawadzki, “Combining adaptive optics with optical coherence tomography: Unveiling the cellular structure of the human retina in vivo,” Expert Rev. Ophthalmol. 2(6), 1019–1035 (2007).
[Crossref]

D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, “Inverse scattering for frequency-scanned full-field optical coherence tomography,” J. Opt. Soc. Am. A 24(4), 1034–1041 (2007).
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Y. Nakamura, S. Makita, M. Yamanari, M. Itoh, T. Yatagai, and Y. Yasuno, “High-speed three-dimensional human retinal imaging by line-field spectral domain optical coherence tomography,” Opt. Express 15(12), 7103–7116 (2007).
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L. Yu, B. Rao, J. Zhang, J. Su, Q. Wang, S. Guo, and Z. Chen, “Improved lateral resolution in optical coherence tomography by digital focusing using two-dimensional numerical diffraction method,” Opt. Express 15(12), 7634–7641 (2007).
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G. Moneron, A. C. Boccara, and A. Dubois, “Polarization-sensitive full-field optical coherence tomography,” Opt. Lett. 32(14), 2058–2060 (2007).
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S. Murali, K. S. Lee, and J. P. Rolland, “Invariant resolution dynamic focus OCM based on liquid crystal lens,” Opt. Express 15(24), 15854–15862 (2007).
[Crossref] [PubMed]

R. A. Leitgeb, R. Michaely, T. Lasser, and S. C. Sekhar, “Complex ambiguity-free Fourier domain optical coherence tomography through transverse scanning,” Opt. Lett. 32(23), 3453–3455 (2007).
[Crossref] [PubMed]

M. Pircher, B. Baumann, E. Götzinger, H. Sattmann, and C. K. Hitzenberger, “Simultaneous SLO/OCT imaging of the human retina with axial eye motion correction,” Opt. Express 15(25), 16922–16932 (2007).
[Crossref] [PubMed]

2006 (14)

A. Bachmann, R. Leitgeb, and T. Lasser, “Heterodyne Fourier domain optical coherence tomography for full range probing with high axial resolution,” Opt. Express 14(4), 1487–1496 (2006).
[Crossref] [PubMed]

D. Merino, C. Dainty, A. Bradu, and A. G. Podoleanu, “Adaptive optics enhanced simultaneous en-face optical coherence tomography and scanning laser ophthalmoscopy,” Opt. Express 14(8), 3345–3353 (2006).
[Crossref] [PubMed]

M. V. Sarunic, S. Weinberg, and J. A. Izatt, “Full-field swept-source phase microscopy,” Opt. Lett. 31(10), 1462–1464 (2006).
[Crossref] [PubMed]

R. G. Cucu, A. G. Podoleanu, J. A. Rogers, J. Pedro, and R. B. Rosen, “Combined confocal/en face T-scan-based ultrahigh-resolution optical coherence tomography in vivo retinal imaging,” Opt. Lett. 31(11), 1684–1686 (2006).
[Crossref] [PubMed]

Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, “High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography,” Opt. Express 14(10), 4380–4394 (2006).
[Crossref] [PubMed]

M. Pircher, B. Baumann, E. Götzinger, and C. K. Hitzenberger, “Retinal cone mosaic imaged with transverse scanning optical coherence tomography,” Opt. Lett. 31(12), 1821–1823 (2006).
[Crossref] [PubMed]

K. Wiesauer, M. Pircher, E. Goetzinger, C. K. Hitzenberger, R. Engelke, G. Ahrens, G. Gruetzner, and D. Stifter, “Transversal ultrahigh-resolution polarizationsensitive optical coherence tomography for strain mapping in materials,” Opt. Express 14(13), 5945–5953 (2006).
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R. A. Leitgeb, M. Villiger, A. H. Bachmann, L. Steinmann, and T. Lasser, “Extended focus depth for Fourier domain optical coherence microscopy,” Opt. Lett. 31(16), 2450–2452 (2006).
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B. Povazay, A. Unterhuber, B. Hermann, H. Sattmann, H. Arthaber, and W. Drexler, “Full-field time-encoded frequency-domain optical coherence tomography,” Opt. Express 14(17), 7661–7669 (2006).
[Crossref] [PubMed]

S. Makita, Y. Hong, M. Yamanari, T. Yatagai, and Y. Yasuno, “Optical coherence angiography,” Opt. Express 14(17), 7821–7840 (2006).
[Crossref] [PubMed]

W. Y. Oh, B. E. Bouma, N. Iftimia, R. Yelin, and G. J. Tearney, “Spectrally-modulated full-field optical coherence microscopy for ultrahigh-resolution endoscopic imaging,” Opt. Express 14(19), 8675–8684 (2006).
[Crossref] [PubMed]

M. Pircher, E. Götzinger, and C. K. Hitzenberger, “Dynamic focus in optical coherence tomography for retinal imaging,” J. Biomed. Opt. 11(5), 054013 (2006).
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A. Dubois and C. Boccara, “[Full-field OCT],” Med. Sci. (Paris) 22(10), 859–864 (2006).
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M. E. J. van Velthoven, F. D. Verbraak, L. A. Yannuzzi, R. B. Rosen, A. G. H. Podoleanu, and M. D. de Smet, “Imaging the retina by en face optical coherence tomography,” Retina 26(2), 129–136 (2006).
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2005 (8)

U. M. Schmidt-Erfurth, R. Leitgeb, S. Michels, S. Sacu, B. Povazay, B. Hermann, C. Ahlers, C. Scholda, H. Sattmann, and W. Drexler, “Three-dimensional ultrahigh resolution optical coherence tomography (3D UHR OCT): A video presentation,” Invest. Ophthalmol. Vis. Sci. 46, 3393 (2005).
[Crossref] [PubMed]

E. J. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattmann, P. M. Prieto, R. Leitgeb, P. Ahnelt, P. Artal, and W. Drexler, “Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using a liquid crystal spatial light modulator,” Vision Res. 45(28), 3432–3444 (2005).
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A. Pallikaris, “Adaptive optics ophthalmoscopy: results and applications,” J. Refract. Surg. 21(5), S570–S574 (2005).
[PubMed]

G. M. Dobre, A. G. Podoleanu, and R. B. Rosen, “Simultaneous optical coherence tomography--Indocyanine Green dye fluorescence imaging system for investigations of the eye’s fundus,” Opt. Lett. 30(1), 58–60 (2005).
[Crossref] [PubMed]

S. Jiao, R. Knighton, X. Huang, G. Gregori, and C. Puliafito, “Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography,” Opt. Express 13(2), 444–452 (2005).
[Crossref] [PubMed]

Y. Zhang, J. Rha, R. Jonnal, and D. Miller, “Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina,” Opt. Express 13(12), 4792–4811 (2005).
[Crossref] [PubMed]

R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, “Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging,” Opt. Express 13(21), 8532–8546 (2005).
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R. Huber, M. Wojtkowski, J. G. Fujimoto, J. Y. Jiang, and A. E. Cable, “Three-dimensional and C-mode OCT imaging with a compact, frequency swept laser source at 1300 nm,” Opt. Express 13(26), 10523–10538 (2005).
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2004 (9)

S. H. Yun, G. Tearney, J. de Boer, and B. Bouma, “Motion artifacts in optical coherence tomography with frequency-domain ranging,” Opt. Express 12(13), 2977–2998 (2004).
[Crossref] [PubMed]

M. Pircher, E. Goetzinger, R. Leitgeb, and C. Hitzenberger, “Three dimensional polarization sensitive OCT of human skin in vivo,” Opt. Express 12(14), 3236–3244 (2004).
[Crossref] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, H. Sattmann, O. Findl, and C. Hitzenberger, “Imaging of polarization properties of human retina in vivo with phase resolved transversal PS-OCT,” Opt. Express 12(24), 5940–5951 (2004).
[Crossref] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(8), 2606–2612 (2004).
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A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, “Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy,” J. Biomed. Opt. 9(1), 86–93 (2004).
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K. Grieve, M. Paques, A. Dubois, J. Sahel, C. Boccara, and J.-F. Le Gargasson, “Ocular tissue imaging using ultrahigh-resolution, full-field optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 45(11), 4126–4131 (2004).
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M. Pircher, E. Goetzinger, R. Leitgeb, and C. K. Hitzenberger, “Transversal phase resolved polarization sensitive optical coherence tomography,” Phys. Med. Biol. 49(7), 1257–1263 (2004).
[Crossref] [PubMed]

E. Götzinger, M. Pircher, M. Sticker, A. F. Fercher, and C. K. Hitzenberger, “Measurement and imaging of birefringent properties of the human cornea with phase-resolved, polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 94–102 (2004).
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B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, “In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography,” J. Biomed. Opt. 9(1), 121–125 (2004).
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2003 (10)

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, “Optical coherence tomography today: speed, contrast, and multimodality,” J. Biomed. Opt. 19, 071412 (2003).

B. Park, M. Pierce, B. Cense, and J. de Boer, “Real-time multi-functional optical coherence tomography,” Opt. Express 11(7), 782–793 (2003).
[Crossref] [PubMed]

R. Leitgeb, C. Hitzenberger, and A. Fercher, “Performance of fourier domain vs. time domain optical coherence tomography,” Opt. Express 11(8), 889–894 (2003).
[Crossref] [PubMed]

M. Akiba, K. P. Chan, and N. Tanno, “Full-field optical coherence tomography by two-dimensional heterodyne detection with a pair of CCD cameras,” Opt. Lett. 28(10), 816–818 (2003).
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J. Moreau, V. Loriette, and A. C. Boccara, “Full-field birefringence imaging by thermal-light polarization-sensitive optical coherence tomography. I. Theory,” Appl. Opt. 42(19), 3800–3810 (2003).
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J. Moreau, V. Loriette, and A. C. Boccara, “Full-field birefringence imaging by thermal-light polarization-sensitive optical coherence tomography. II. Instrument and results,” Appl. Opt. 42(19), 3811–3818 (2003).
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C. Hitzenberger, P. Trost, P. W. Lo, and Q. Zhou, “Three-dimensional imaging of the human retina by high-speed optical coherence tomography,” Opt. Express 11(21), 2753–2761 (2003).
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J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, “Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography,” Opt. Lett. 28(21), 2067–2069 (2003).
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R. Leitgeb, L. Schmetterer, W. Drexler, A. Fercher, R. Zawadzki, and T. Bajraszewski, “Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography,” Opt. Express 11(23), 3116–3121 (2003).
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M. Choma, M. Sarunic, C. Yang, and J. Izatt, “Sensitivity advantage of swept source and Fourier domain optical coherence tomography,” Opt. Express 11(18), 2183–2189 (2003).
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2002 (5)

2001 (3)

2000 (2)

1999 (1)

F. Lexer, C. K. Hitzenberger, W. Drexler, S. Molebny, H. Sattmann, M. Sticker, and A. F. Fercher, “Dynamic coherent focus OCT with depth-independent transversal resolution,” J. Mod. Opt. 46(3), 541–553 (1999).
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1998 (4)

A. G. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson, and F. W. Fitzke, “Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry,” J. Biomed. Opt. 3(1), 12–20 (1998).
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A. G. Podoleanu and D. A. Jackson, “Combined optical coherence tomograph and scanning laser ophthalmoscope,” Electron. Lett. 34(11), 1088–1090 (1998).
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A. G. Podoleanu, G. M. Dobre, and D. A. Jackson, “En-face coherence imaging using galvanometer scanner modulation,” Opt. Lett. 23(3), 147–149 (1998).
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E. Beaurepaire, A. C. Boccara, M. Lebec, L. Blanchot, and H. Saint-Jalmes, “Full-field optical coherence microscopy,” Opt. Lett. 23(4), 244–246 (1998).
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1997 (6)

1996 (1)

1995 (1)

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of Intraocular Distances by Backscattering Spectral Interferometry,” Opt. Commun. 117(1-2), 43–48 (1995).
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1994 (1)

1992 (1)

1990 (1)

J. Schwider, “Advanced Evaluation Techniques in Interferometry,” Prog. Opt. 28, 271–359 (1990).
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1987 (1)

Adie, S. G.

N. D. Shemonski, F. A. South, Y.-Z. Liu, S. G. Adie, P. S. Carney, and S. A. Boppart, “Computational high-resolution optical imaging of the living human retina,” Nat. Photonics 9(7), 440–443 (2015).
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Hilge, Felix

Clara Pfäffle, Dierck Hillmann, Hendrik Spahr, Lisa Kutzner, Sazan Burhan, Felix Hilge, Yoko Miura, and G. Hüttmann, “Functional imaging of ganglion and receptor cells in living human retina by osmotic contrast,” http://arXiv1605.02959 (2018).

Hillmann, D.

Hillmann, Dierck

Clara Pfäffle, Dierck Hillmann, Hendrik Spahr, Lisa Kutzner, Sazan Burhan, Felix Hilge, Yoko Miura, and G. Hüttmann, “Functional imaging of ganglion and receptor cells in living human retina by osmotic contrast,” http://arXiv1605.02959 (2018).

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C. Ahlers, E. Götzinger, M. Pircher, I. Golbaz, F. Prager, C. Schütze, B. Baumann, C. K. Hitzenberger, and U. Schmidt-Erfurth, “Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization-sensitive optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(4), 2149–2157 (2010).
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M. Pircher, B. Baumann, E. Götzinger, H. Sattmann, and C. K. Hitzenberger, “Phase contrast coherence microscopy based on transverse scanning,” Opt. Lett. 34(12), 1750–1752 (2009).
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D. Hillmann, T. Bonin, C. Lührs, G. Franke, M. Hagen-Eggert, P. Koch, and G. Hüttmann, “Common approach for compensation of axial motion artifacts in swept-source OCT and dispersion in Fourier-domain OCT,” Opt. Express 20(6), 6761–6776 (2012).
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Clara Pfäffle, Dierck Hillmann, Hendrik Spahr, Lisa Kutzner, Sazan Burhan, Felix Hilge, Yoko Miura, and G. Hüttmann, “Functional imaging of ganglion and receptor cells in living human retina by osmotic contrast,” http://arXiv1605.02959 (2018).

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A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of Intraocular Distances by Backscattering Spectral Interferometry,” Opt. Commun. 117(1-2), 43–48 (1995).
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Kuo, A. N.

Kutzner, Lisa

Clara Pfäffle, Dierck Hillmann, Hendrik Spahr, Lisa Kutzner, Sazan Burhan, Felix Hilge, Yoko Miura, and G. Hüttmann, “Functional imaging of ganglion and receptor cells in living human retina by osmotic contrast,” http://arXiv1605.02959 (2018).

Laissue, P.

Larin, K. V.

Laslandes, M.

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O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large field, high resolution full-field optical coherence tomography: a pre-clinical study of human breast tissue and cancer assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
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M. Pircher, E. Goetzinger, R. Leitgeb, and C. Hitzenberger, “Three dimensional polarization sensitive OCT of human skin in vivo,” Opt. Express 12(14), 3236–3244 (2004).
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A. Kumar, T. Kamali, R. Platzer, A. Unterhuber, W. Drexler, and R. A. Leitgeb, “Anisotropic aberration correction using region of interest based digital adaptive optics in Fourier domain OCT,” Biomed. Opt. Express 6(4), 1124–1134 (2015).
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M. Bonesi, M. P. Minneman, J. Ensher, B. Zabihian, H. Sattmann, P. Boschert, E. Hoover, R. A. Leitgeb, M. Crawford, and W. Drexler, “Akinetic all-semiconductor programmable swept-source at 1550 nm and 1310 nm with centimeters coherence length,” Opt. Express 22(3), 2632–2655 (2014).
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C. Blatter, T. Klein, B. Grajciar, T. Schmoll, W. Wieser, R. Andre, R. Huber, and R. A. Leitgeb, “Ultrahigh-speed non-invasive widefield angiography,” J. Biomed. Opt. 17(7), 070505 (2012).
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C. Blatter, B. Grajciar, C. M. Eigenwillig, W. Wieser, B. R. Biedermann, R. Huber, and R. A. Leitgeb, “Extended focus high-speed swept source OCT with self-reconstructive illumination,” Opt. Express 19(13), 12141–12155 (2011).
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A. S. G. Singh, C. Kolbitsch, T. Schmoll, and R. A. Leitgeb, “Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans,” Biomed. Opt. Express 1(4), 1047–1058 (2010).
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M. Pircher, E. Götzinger, H. Sattmann, R. A. Leitgeb, and C. K. Hitzenberger, “In vivo investigation of human cone photoreceptors with SLO/OCT in combination with 3D motion correction on a cellular level,” Opt. Express 18(13), 13935–13944 (2010).
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T. Schmoll, C. Kolbitsch, and R. A. Leitgeb, “In vivo functional retinal optical coherence tomography,” J. Biomed. Opt. 15(4), 041513 (2010).
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M. Salas, M. Augustin, L. Ginner, A. Kumar, B. Baumann, R. Leitgeb, W. Drexler, S. Prager, J. Hafner, U. Schmidt-Erfurth, and M. Pircher, “Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics,” Biomed. Opt. Express 8(1), 207–222 (2016).
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M. Sugita, M. Pircher, S. Zotter, B. Baumann, P. Roberts, T. Makihira, N. Tomatsu, M. Sato, C. Vass, and C. K. Hitzenberger, “Retinal nerve fiber bundle tracing and analysis in human eye by polarization sensitive OCT,” Biomed. Opt. Express 6(3), 1030–1054 (2015).
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C. Blatter, B. Grajciar, C. M. Eigenwillig, W. Wieser, B. R. Biedermann, R. Huber, and R. A. Leitgeb, “Extended focus high-speed swept source OCT with self-reconstructive illumination,” Opt. Express 19(13), 12141–12155 (2011).
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M. Pircher, E. Götzinger, H. Sattmann, R. A. Leitgeb, and C. K. Hitzenberger, “In vivo investigation of human cone photoreceptors with SLO/OCT in combination with 3D motion correction on a cellular level,” Opt. Express 18(13), 13935–13944 (2010).
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S. H. Yun, G. Tearney, J. de Boer, and B. Bouma, “Motion artifacts in optical coherence tomography with frequency-domain ranging,” Opt. Express 12(13), 2977–2998 (2004).
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M. Pircher, E. Götzinger, R. Leitgeb, H. Sattmann, O. Findl, and C. Hitzenberger, “Imaging of polarization properties of human retina in vivo with phase resolved transversal PS-OCT,” Opt. Express 12(24), 5940–5951 (2004).
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D. Merino, C. Dainty, A. Bradu, and A. G. Podoleanu, “Adaptive optics enhanced simultaneous en-face optical coherence tomography and scanning laser ophthalmoscopy,” Opt. Express 14(8), 3345–3353 (2006).
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C. Hitzenberger, E. Goetzinger, M. Sticker, M. Pircher, and A. Fercher, “Measurement and imaging of birefringence and optic axis orientation by phase resolved polarization sensitive optical coherence tomography,” Opt. Express 9(13), 780–790 (2001).
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M. Pircher, E. Goetzinger, R. Leitgeb, and C. Hitzenberger, “Three dimensional polarization sensitive OCT of human skin in vivo,” Opt. Express 12(14), 3236–3244 (2004).
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B. Park, M. Pierce, B. Cense, and J. de Boer, “Real-time multi-functional optical coherence tomography,” Opt. Express 11(7), 782–793 (2003).
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A. Roorda, F. Romero-Borja, W. Donnelly Iii, H. Queener, T. Hebert, and M. Campbell, “Adaptive optics scanning laser ophthalmoscopy,” Opt. Express 10(9), 405–412 (2002).
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R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, “Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging,” Opt. Express 13(21), 8532–8546 (2005).
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Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, “High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography,” Opt. Express 14(10), 4380–4394 (2006).
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Y. Zhang, J. Rha, R. Jonnal, and D. Miller, “Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina,” Opt. Express 13(12), 4792–4811 (2005).
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M. Pircher, B. Baumann, E. Götzinger, H. Sattmann, and C. K. Hitzenberger, “Simultaneous SLO/OCT imaging of the human retina with axial eye motion correction,” Opt. Express 15(25), 16922–16932 (2007).
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Y. Nakamura, S. Makita, M. Yamanari, M. Itoh, T. Yatagai, and Y. Yasuno, “High-speed three-dimensional human retinal imaging by line-field spectral domain optical coherence tomography,” Opt. Express 15(12), 7103–7116 (2007).
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A. A. Grebenyuk, L. Ginner, and R. A. Leitgeb, “Numerically focused full-field swept-source optical coherence microscopy with structured illumination,” Opt. Express 26(26), 33772–33782 (2018).
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M.-K. Kim, “Tomographic three-dimensional imaging of a biological specimen using wavelength-scanning digital interference holography,” Opt. Express 7(9), 305–310 (2000).
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B. Povazay, A. Unterhuber, B. Hermann, H. Sattmann, H. Arthaber, and W. Drexler, “Full-field time-encoded frequency-domain optical coherence tomography,” Opt. Express 14(17), 7661–7669 (2006).
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D. Hillmann, H. Spahr, H. Sudkamp, C. Hain, L. Hinkel, G. Franke, and G. Hüttmann, “Off-axis reference beam for full-field swept-source OCT and holoscopy,” Opt. Express 25(22), 27770–27784 (2017).
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W. Y. Oh, B. E. Bouma, N. Iftimia, R. Yelin, and G. J. Tearney, “Spectrally-modulated full-field optical coherence microscopy for ultrahigh-resolution endoscopic imaging,” Opt. Express 14(19), 8675–8684 (2006).
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D. Hillmann, T. Bonin, C. Lührs, G. Franke, M. Hagen-Eggert, P. Koch, and G. Hüttmann, “Common approach for compensation of axial motion artifacts in swept-source OCT and dispersion in Fourier-domain OCT,” Opt. Express 20(6), 6761–6776 (2012).
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D. Hillmann, G. Franke, C. Lührs, P. Koch, and G. Hüttmann, “Efficient holoscopy image reconstruction,” Opt. Express 20(19), 21247–21263 (2012).
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A. Kumar, W. Drexler, and R. A. Leitgeb, “Subaperture correlation based digital adaptive optics for full field optical coherence tomography,” Opt. Express 21(9), 10850–10866 (2013).
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C. M. Eigenwillig, B. R. Biedermann, G. Palte, and R. Huber, “K-space linear Fourier domain mode locked laser and applications for optical coherence tomography,” Opt. Express 16(12), 8916–8937 (2008).
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M. Bonesi, M. P. Minneman, J. Ensher, B. Zabihian, H. Sattmann, P. Boschert, E. Hoover, R. A. Leitgeb, M. Crawford, and W. Drexler, “Akinetic all-semiconductor programmable swept-source at 1550 nm and 1310 nm with centimeters coherence length,” Opt. Express 22(3), 2632–2655 (2014).
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A. Bradu, M. Maria, and A. G. Podoleanu, “Demonstration of tolerance to dispersion of master/slave interferometry,” Opt. Express 23(11), 14148–14161 (2015).
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H. Spahr, C. Pfäffle, P. Koch, H. Sudkamp, G. Hüttmann, and D. Hillmann, “Interferometric detection of 3D motion using computational subapertures in optical coherence tomography,” Opt. Express 26(15), 18803–18816 (2018).
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Opt. Laser Technol. (1)

R. Poddar and J. S. Werner, “Implementations of three OCT angiography (OCTA) methods with 1.7 MHz A-scan rate OCT system on imaging of human retinal and choroidal vasculature,” Opt. Laser Technol. 102, 130–139 (2018).
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R. G. Cucu, A. G. Podoleanu, J. A. Rogers, J. Pedro, and R. B. Rosen, “Combined confocal/en face T-scan-based ultrahigh-resolution optical coherence tomography in vivo retinal imaging,” Opt. Lett. 31(11), 1684–1686 (2006).
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M. Pircher, E. Goetzinger, R. Leitgeb, and C. K. Hitzenberger, “Transversal phase resolved polarization sensitive optical coherence tomography,” Phys. Med. Biol. 49(7), 1257–1263 (2004).
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Phys. Rev. Lett. (1)

S. M. Popoff, G. Lerosey, R. Carminati, M. Fink, A. C. Boccara, and S. Gigan, “Measuring the transmission matrix in optics: an approach to the study and control of light propagation in disordered media,” Phys. Rev. Lett. 104(10), 100601 (2010).
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A. G. Podoleanu and R. B. Rosen, “Combinations of techniques in imaging the retina with high resolution,” Prog. Retin. Eye Res. 27(4), 464–499 (2008).
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R. A. Leitgeb, R. M. Werkmeister, C. Blatter, and L. Schmetterer, “Doppler optical coherence tomography,” Prog. Retin. Eye Res. 41, 26–43 (2014).
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M. E. J. van Velthoven, F. D. Verbraak, L. A. Yannuzzi, R. B. Rosen, A. G. H. Podoleanu, and M. D. de Smet, “Imaging the retina by en face optical coherence tomography,” Retina 26(2), 129–136 (2006).
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R. J. Zawadzki and D. T. Miller, “Retinal AO OCT,” in Optical Coherence Tomography: Technology and Applications, Second Edition (2015), pp. 1849–1920.

B. Hermann, E. Fernández, A. Unterhuber, H. Sattmann, A. Fercher, W. Drexler, P. Prieto, and P. Artal, “Adaptive-optics ultrahigh-resolution optical coherence tomography,” Opt. Lett. 29, 2142–2144 (2004).
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B. Grajciar, M. Pircher, A. F. Fercher, and R. A. Leitgeb, “Parallel Fourier domain optical coherence tomography, measurement of the human eye in vivo,” in Coherence Domain Optical Methods And Optical Coherence Tomography In Biomedicine Ix (2005), pp. 163–167.

Y. Yasuno, T. Endo, S. Makita, G. Aoki, M. Itoh, and T. Yatagai, “Three-dimensional line-field Fourier domain optical coherence tomography for in vivo dermatological investigation,” Journal of Biomedical Optics 11, 014014 (2006).
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S. B. Stevenson and A. Roorda, “Correcting for miniature eye movements in high resolution scanning laser ophthalmoscopy,” in Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 2005), 145–151.

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J. Holmes and S. Hattersley, “Image blending and speckle noise reduction in multi-beam OCT,” in Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 2009)

D. T. Miller, J. Qu, R. S. Jonnal, and K. E. Thorn, “Coherence gating and adaptive optics in the eye,” in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII, (International Society for Optics and Photonics, 2003), 65–73.

R. Leitgeb, L. Schmetterer, M. Wojtkowski, C. Hitzenberger, M. Sticker, and A. Fercher, “Flow Velocity Measurements by Frequency Domain Short Coherence Interferometry,” SPIE Proceedings 4619, 16–21 (2002).
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Z. Liu, K. Kurokawa, F. Zhang, J. J. Lee, and D. T. Miller, “Imaging and quantifying ganglion cells and other transparent neurons in the living human retina,” Proceedings of the National Academy of Sciences, 201711734 (2017).
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L. Gorczynska, J. V. Migacz, R. S. Jonnal, R. J. Zawadzki, and J. S. Werner, “Influence of speed and resolution on OCT angiography and Doppler OCT imaging in human retinal and choroidal capillary systems,” in 2016 IEEE Photonics Conference, IPC 2016, 2017), 140–141.

R. Leitgeb, L. Schmetterer, M. Wojtkowski, C. K. Hitzenberger, M. Sticker, and A. F. Fercher, “Flow velocity measurements by frequency domain short coherence interferometry,” in Proceedings of SPIE-The International Society for Optical Engineering, 2002), 16–21.
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P. Roberts, M. Sugita, G. Deák, B. Baumann, S. Zotter, M. Pircher, S. Sacu, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Automated Identification and Quantification of Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration Using Polarization-Sensitive OCTFibrosis in PS-OCT," Investigative Ophthalmology & Visual Science 57, 1699-1705 (2016).
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D. Hillmann, H. Spahr, C. Pfäffle, H. Sudkamp, G. Franke, and G. Hüttmann, “In vivo optical imaging of physiological responses to photostimulation in human photoreceptors,” arXiv preprint arXiv:1605.02959 (2016).
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Figures (13)

Fig. 1
Fig. 1 Scanning preference for conventional TD OCT in the axial direction (lhs). En face TDOCT uses the transversal direction for fast scanning (rhs) and is comparably slow in axial direction. This figure sets also the axis notations for the following discussions in the text.
Fig. 2
Fig. 2 Overview on OCT technology with TDOCT on the left and FDOCT on the right hand side: (a) TS en face OCT with SLO channel and balanced detection (b) FFOCT and SS FFOCT (c) SS OCT with balanced detection (d) spectral domain OCT using a spectrometer with a diffraction grating and a line array sensor.
Fig. 3
Fig. 3 SCOPUST search result for “en-face optical coherence tomography” OR “en face optical coherence tomography”. Three eras of en face OCT may be discerned. (OCTA – OCT angiography)
Fig. 4
Fig. 4 Carrier frequency generation for en face TDOCT (a) setting the sample beam off the pivot position on the fast scanning galvo mirror; (b) using an off-axis reference arm configuration in parallel OCT variants for holographic signal reconstruction. The red edge shows the Fourier filter function to filter out the spatially modulated OCT signal.
Fig. 5
Fig. 5 Clinical examples of combined en face TS OCT and SLO. Reproduced from [37]with permission from The Optical Society (OSA).
Fig. 6
Fig. 6 Scheme of an axially tracked SLO/TS OCT instrument. Fast axial tracking is realized via a rapid scanning optical delay line (RSOD) with the axial signal from a spectral domain low coherence interferometer (SD-LCI) operating at 1300nm. LS light source, P polarizer, DC dispersion compensation glass rods, BS beam splitter, L1-L4 lenses, AOM acousto optic modulator, TS translation stage, PBS polarizing beam splitter, DM dichroic mirror, RM reference mirror, DG diffraction grating, Pe Pellicle, GS galvo scanner including one resonant scanner (reproduced from Pircher et al. [61] with permission of The Optical Society (OSA)).
Fig. 7
Fig. 7 Phase contrast OCM of human erythrocytes: (a) OCT intensity image, (b) perspective quantitative phase image of the region marked with a rectangle in (a).(c) Quantitative phase image of eurythrocytes obtained with SS FF OCT(reproduced from [66] and [[67]]with permission of The Optical Society (OSA)).
Fig. 8
Fig. 8 Imaging examples for FF OCT: SS FF OCT in-vivo results of human retina showing (a) a rendered 3D volume and (b) a corresponding tomogram (10 times averaged) exhibiting good contrast for the inner retinal layers and loss of contrast for the choroidal structures (reproduced from [88] with permission of The Optical Society); (c-f) TD FF OCT results of ex-vivo retinal tissue (Republished with permission of the Association for Research in Vision and Ophthalmology from [5]; permission conveyed through Copyright Clearance Center, Inc.)
Fig. 9
Fig. 9 en-face SLO image (a) and averaged OCT image (b) (over 40 frames) (recorded at an imaging depth corresponding to the layer between RPE and end tips of cones at 8 degrees temporally from the fovea). (c) Composite false color image of end tips of cones (red), and layer displayed in (b) (green) (scale bars: 30μm).(reproduced from [124] with permission from The Optical Society (OSA))
Fig. 10
Fig. 10 En-face images exhibiting cellular details at different depths: (a) rendered volume; (b) GCL-ganglion cell layer; (c) RPE-retinal pigment epithelium;(reproduced from [65] with permission from PNAS).
Fig. 11
Fig. 11 Images of an eye with fibrotic neovascular age-related macula degeneration. (a) Color fundus photo; (b) fluorescein angiography; (c) en face PS-OCT mean retardation map; (d) en face PS-OCT reflectivity projection map; (e) en face PS-OCT median retardation map; (f) en face PS-OCT axis orientation map; (g) PS- OCT reflectivity B-scan; (h) same B-scan with segmented retinal pigment epithelium based on its depolarization effect (red); (i) PS-OCT axis orientation B-scan, fibrotic tissue generates column-like color pattern (color bar: −90 - + 90°); (j) PS-OCT retardation B-scan, fibrotic tissue is strongly birefringent (color bar: 0 – 90°). (Republished with permission of the Association for Research in Vision and Ophthalmology from [164]; permission conveyed through Copyright Clearance Center, Inc.)
Fig. 12
Fig. 12 Scheme of OCT angiography (OCTA) processing steps. (a) OCTA analysis is performed between tomograms;(b) OCTA en face maps are produced by projection over selected depth regions. (c-d) en face OCTA maps of the inner retina capillary structure and of the choroicapillary layer below the retinal pigment epithelium. (reproduced from [158] with permission from SPIE)
Fig. 13
Fig. 13 OCTA of geographic atrophy; (a) B-scan (grey) with overlaid OCTA tomogram (red); (b) en face OCTA with depth color coding according to the color bars to the right of (a) (with permission from [160] by The Optical Society (OSA)).