Abstract

Brillouin spectroscopy has emerged as a novel analytical tool for biophotonic research and applications. It operates on a microscopic scale and in the GHz spectral range, providing a new spatial and frequency window for the analysis of the materials elasticity. Here we investigate spectral moments calculation as a means of analysing Brillouin and Raman spectra, providing rapid access to peak intensity and frequency shift, with robust application to fast scanning measurements. This work demonstrates the potential of the method, especially in the case of micro-structured samples, typical of bio-medical applications.

Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.

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References

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    [Crossref] [PubMed]
  4. S. Martino, F. D’Angelo, I. Armentano, J. M. Kenny, and A. Orlacchio, “Stem cell-biomaterial interactions for regenerative medicine,” Biotechnol. Adv. 30(1), 338–351 (2012).
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref]
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    [Crossref] [PubMed]
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    [PubMed]
  25. S. Mattana, M. Alunni Cardinali, S. Caponi, D. Casagrande Pierantoni, L. Corte, L. Roscini, G. Cardinali, and D. Fioretto, “High-contrast Brillouin and Raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms,” Biophys. Chem. 229, 123–129 (2017).
    [PubMed]
  26. H. Liu and W. Yu, “Study of the structure transformation of wool fibers with Raman spectroscopy,” J. Appl. Polym. Sci. 103(1), 1–7 (2007).
    [Crossref]
  27. R. Hardis, J. L. P. Jessop, F. E. Peters, and M. R. Kessler, “Cure kinetics characterization and monitoring of an epoxy resin using DSC, Raman spectroscopy, and DEA,” Compos., Part A Appl. Sci. Manuf. 49, 100–108 (2013).
    [Crossref]

2018 (2)

C. E. Bottani and D. Fioretto, “Advances in Physics : X Brillouin scattering of phonons in complex materials,” Advances in Physics: X 6149, 1– 27 (2018).

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by micro-spectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref]

2017 (5)

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, and F. Palombo, “Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis,” J. Innov. Opt. Health Sci. 10(6), 1742001 (2017).
[Crossref] [PubMed]

S. Mattana, M. Alunni Cardinali, S. Caponi, D. Casagrande Pierantoni, L. Corte, L. Roscini, G. Cardinali, and D. Fioretto, “High-contrast Brillouin and Raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms,” Biophys. Chem. 229, 123–129 (2017).
[PubMed]

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

K. V. Larin and D. D. Sampson, “Optical coherence elastography - OCT at work in tissue biomechanics [Invited],” Biomed. Opt. Express 8(2), 1172–1202 (2017).
[Crossref] [PubMed]

2016 (1)

Z. Meng, A. J. Traverso, C. W. Ballmann, M. Troyanova-Wood, and V. V. Yakovlev, “Seeing cells in a new light: a renaissance of Brillouin spectroscopy,” Adv. Opt. Photonics 8(2), 300–327 (2016).
[Crossref]

2015 (3)

G. Scarcelli, S. Besner, R. Pineda, P. Kalout, and S. H. Yun, “In vivo biomechanical mapping of normal and keratoconus corneas,” JAMA Ophthalmol. 133(4), 480–482 (2015).
[Crossref] [PubMed]

G. Antonacci, R. M. Pedrigi, A. Kondiboyina, V. V. Mehta, R. de Silva, C. Paterson, R. Krams, and P. Török, “Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma,” J. R. Soc. Interface 12(112), 20150843 (2015).
[Crossref] [PubMed]

J. M. Phillip, I. Aifuwa, J. Walston, and D. Wirtz, “The Mechanobiology of Aging,” Annu. Rev. Biomed. Eng. 17(1), 113–141 (2015).
[Crossref] [PubMed]

2014 (3)

G. Scarcelli, S. Besner, R. Pineda, and S. H. Yun, “Biomechanical characterization of keratoconus corneas ex vivo with Brillouin microscopy,” Invest. Ophthalmol. Vis. Sci. 55(7), 4490–4495 (2014).
[Crossref] [PubMed]

F. Palombo, M. Madami, N. Stone, and D. Fioretto, “Mechanical mapping with chemical specificity by confocal Brillouin and Raman microscopy,” Analyst (Lond.) 139(4), 729–733 (2014).
[Crossref] [PubMed]

S. Caponi, S. Corezzi, M. Mattarelli, and D. Fioretto, “Stress effects on the elastic properties of amorphous polymeric materials,” J. Chem. Phys. 141(21), 214901 (2014).
[PubMed]

2013 (2)

R. Hardis, J. L. P. Jessop, F. E. Peters, and M. R. Kessler, “Cure kinetics characterization and monitoring of an epoxy resin using DSC, Raman spectroscopy, and DEA,” Compos., Part A Appl. Sci. Manuf. 49, 100–108 (2013).
[Crossref]

S. Caponi, L. Liguori, A. Giugliarelli, M. Mattarelli, A. Morresi, P. Sassi, L. Urbanelli, and C. Musio, “Raman micro-spectroscopy: a powerful tool for the monitoring of dynamic supramolecular changes in living cells,” Biophys. Chem. 182, 58–63 (2013).
[PubMed]

2012 (3)

S. Martino, F. D’Angelo, I. Armentano, J. M. Kenny, and A. Orlacchio, “Stem cell-biomaterial interactions for regenerative medicine,” Biotechnol. Adv. 30(1), 338–351 (2012).
[Crossref] [PubMed]

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

M. Lekka, “Atomic force microscopy: A tip for diagnosing cancer,” Nat. Nanotechnol. 7(11), 691–692 (2012).

2011 (1)

V. Swaminathan, K. Mythreye, E. T. O’Brien, A. Berchuck, G. C. Blobe, and R. Superfine, “Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines,” Cancer Res. 71(15), 5075–5080 (2011).
[Crossref] [PubMed]

2010 (1)

T. Still, M. Mattarelli, D. Kiefer, G. Fytas, and M. Montagna, “Eigenvibrations of submicrometer colloidal spheres,” J. Phys. Chem. Lett. 1(16), 2440–2444 (2010).
[Crossref]

2007 (2)

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

H. Liu and W. Yu, “Study of the structure transformation of wool fibers with Raman spectroscopy,” J. Appl. Polym. Sci. 103(1), 1–7 (2007).
[Crossref]

2006 (1)

A. J. Engler, S. Sen, H. L. Sweeney, and D. E. Discher, “Matrix elasticity directs stem cell lineage specification,” Cell 126(4), 677–689 (2006).
[Crossref] [PubMed]

2004 (1)

S. Caponi, G. Carini, G. D’Angelo, A. Fontana, O. Pilla, F. Rossi, F. Terki, G. Tripodo, and T. Woignier, “Acoustic and thermal properties of silica aerogels and xerogels,” Phys. Rev. B 70(21), 214204 (2004).
[Crossref]

Aifuwa, I.

J. M. Phillip, I. Aifuwa, J. Walston, and D. Wirtz, “The Mechanobiology of Aging,” Annu. Rev. Biomed. Eng. 17(1), 113–141 (2015).
[Crossref] [PubMed]

Alunni Cardinali, M.

S. Mattana, M. Alunni Cardinali, S. Caponi, D. Casagrande Pierantoni, L. Corte, L. Roscini, G. Cardinali, and D. Fioretto, “High-contrast Brillouin and Raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms,” Biophys. Chem. 229, 123–129 (2017).
[PubMed]

Antonacci, G.

G. Antonacci, R. M. Pedrigi, A. Kondiboyina, V. V. Mehta, R. de Silva, C. Paterson, R. Krams, and P. Török, “Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma,” J. R. Soc. Interface 12(112), 20150843 (2015).
[Crossref] [PubMed]

Armellini, C.

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

Armentano, I.

S. Martino, F. D’Angelo, I. Armentano, J. M. Kenny, and A. Orlacchio, “Stem cell-biomaterial interactions for regenerative medicine,” Biotechnol. Adv. 30(1), 338–351 (2012).
[Crossref] [PubMed]

Ballmann, C. W.

Z. Meng, A. J. Traverso, C. W. Ballmann, M. Troyanova-Wood, and V. V. Yakovlev, “Seeing cells in a new light: a renaissance of Brillouin spectroscopy,” Adv. Opt. Photonics 8(2), 300–327 (2016).
[Crossref]

Berchuck, A.

V. Swaminathan, K. Mythreye, E. T. O’Brien, A. Berchuck, G. C. Blobe, and R. Superfine, “Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines,” Cancer Res. 71(15), 5075–5080 (2011).
[Crossref] [PubMed]

Besner, S.

G. Scarcelli, S. Besner, R. Pineda, P. Kalout, and S. H. Yun, “In vivo biomechanical mapping of normal and keratoconus corneas,” JAMA Ophthalmol. 133(4), 480–482 (2015).
[Crossref] [PubMed]

G. Scarcelli, S. Besner, R. Pineda, and S. H. Yun, “Biomechanical characterization of keratoconus corneas ex vivo with Brillouin microscopy,” Invest. Ophthalmol. Vis. Sci. 55(7), 4490–4495 (2014).
[Crossref] [PubMed]

Blobe, G. C.

V. Swaminathan, K. Mythreye, E. T. O’Brien, A. Berchuck, G. C. Blobe, and R. Superfine, “Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines,” Cancer Res. 71(15), 5075–5080 (2011).
[Crossref] [PubMed]

Bottani, C. E.

C. E. Bottani and D. Fioretto, “Advances in Physics : X Brillouin scattering of phonons in complex materials,” Advances in Physics: X 6149, 1– 27 (2018).

Caponi, S.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by micro-spectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

S. Mattana, M. Alunni Cardinali, S. Caponi, D. Casagrande Pierantoni, L. Corte, L. Roscini, G. Cardinali, and D. Fioretto, “High-contrast Brillouin and Raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms,” Biophys. Chem. 229, 123–129 (2017).
[PubMed]

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, and F. Palombo, “Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis,” J. Innov. Opt. Health Sci. 10(6), 1742001 (2017).
[Crossref] [PubMed]

S. Caponi, S. Corezzi, M. Mattarelli, and D. Fioretto, “Stress effects on the elastic properties of amorphous polymeric materials,” J. Chem. Phys. 141(21), 214901 (2014).
[PubMed]

S. Caponi, L. Liguori, A. Giugliarelli, M. Mattarelli, A. Morresi, P. Sassi, L. Urbanelli, and C. Musio, “Raman micro-spectroscopy: a powerful tool for the monitoring of dynamic supramolecular changes in living cells,” Biophys. Chem. 182, 58–63 (2013).
[PubMed]

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

S. Caponi, G. Carini, G. D’Angelo, A. Fontana, O. Pilla, F. Rossi, F. Terki, G. Tripodo, and T. Woignier, “Acoustic and thermal properties of silica aerogels and xerogels,” Phys. Rev. B 70(21), 214204 (2004).
[Crossref]

Cardinali, G.

S. Mattana, M. Alunni Cardinali, S. Caponi, D. Casagrande Pierantoni, L. Corte, L. Roscini, G. Cardinali, and D. Fioretto, “High-contrast Brillouin and Raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms,” Biophys. Chem. 229, 123–129 (2017).
[PubMed]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

Carini, G.

S. Caponi, G. Carini, G. D’Angelo, A. Fontana, O. Pilla, F. Rossi, F. Terki, G. Tripodo, and T. Woignier, “Acoustic and thermal properties of silica aerogels and xerogels,” Phys. Rev. B 70(21), 214204 (2004).
[Crossref]

Casagrande Pierantoni, D.

S. Mattana, M. Alunni Cardinali, S. Caponi, D. Casagrande Pierantoni, L. Corte, L. Roscini, G. Cardinali, and D. Fioretto, “High-contrast Brillouin and Raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms,” Biophys. Chem. 229, 123–129 (2017).
[PubMed]

Chiappini, A.

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

Chiasera, A.

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

Comez, L.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

Corezzi, S.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

S. Caponi, S. Corezzi, M. Mattarelli, and D. Fioretto, “Stress effects on the elastic properties of amorphous polymeric materials,” J. Chem. Phys. 141(21), 214901 (2014).
[PubMed]

Corte, L.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

S. Mattana, M. Alunni Cardinali, S. Caponi, D. Casagrande Pierantoni, L. Corte, L. Roscini, G. Cardinali, and D. Fioretto, “High-contrast Brillouin and Raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms,” Biophys. Chem. 229, 123–129 (2017).
[PubMed]

D’Angelo, F.

S. Martino, F. D’Angelo, I. Armentano, J. M. Kenny, and A. Orlacchio, “Stem cell-biomaterial interactions for regenerative medicine,” Biotechnol. Adv. 30(1), 338–351 (2012).
[Crossref] [PubMed]

D’Angelo, G.

S. Caponi, G. Carini, G. D’Angelo, A. Fontana, O. Pilla, F. Rossi, F. Terki, G. Tripodo, and T. Woignier, “Acoustic and thermal properties of silica aerogels and xerogels,” Phys. Rev. B 70(21), 214204 (2004).
[Crossref]

de Silva, R.

G. Antonacci, R. M. Pedrigi, A. Kondiboyina, V. V. Mehta, R. de Silva, C. Paterson, R. Krams, and P. Török, “Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma,” J. R. Soc. Interface 12(112), 20150843 (2015).
[Crossref] [PubMed]

Discher, D. E.

A. J. Engler, S. Sen, H. L. Sweeney, and D. E. Discher, “Matrix elasticity directs stem cell lineage specification,” Cell 126(4), 677–689 (2006).
[Crossref] [PubMed]

Emiliani, C.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by micro-spectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

Engler, A. J.

A. J. Engler, S. Sen, H. L. Sweeney, and D. E. Discher, “Matrix elasticity directs stem cell lineage specification,” Cell 126(4), 677–689 (2006).
[Crossref] [PubMed]

Ferrari, M.

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

Fioretto, D.

C. E. Bottani and D. Fioretto, “Advances in Physics : X Brillouin scattering of phonons in complex materials,” Advances in Physics: X 6149, 1– 27 (2018).

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by micro-spectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref]

S. Mattana, M. Alunni Cardinali, S. Caponi, D. Casagrande Pierantoni, L. Corte, L. Roscini, G. Cardinali, and D. Fioretto, “High-contrast Brillouin and Raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms,” Biophys. Chem. 229, 123–129 (2017).
[PubMed]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, and F. Palombo, “Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis,” J. Innov. Opt. Health Sci. 10(6), 1742001 (2017).
[Crossref] [PubMed]

S. Caponi, S. Corezzi, M. Mattarelli, and D. Fioretto, “Stress effects on the elastic properties of amorphous polymeric materials,” J. Chem. Phys. 141(21), 214901 (2014).
[PubMed]

F. Palombo, M. Madami, N. Stone, and D. Fioretto, “Mechanical mapping with chemical specificity by confocal Brillouin and Raman microscopy,” Analyst (Lond.) 139(4), 729–733 (2014).
[Crossref] [PubMed]

Fontana, A.

S. Caponi, G. Carini, G. D’Angelo, A. Fontana, O. Pilla, F. Rossi, F. Terki, G. Tripodo, and T. Woignier, “Acoustic and thermal properties of silica aerogels and xerogels,” Phys. Rev. B 70(21), 214204 (2004).
[Crossref]

Fytas, G.

T. Still, M. Mattarelli, D. Kiefer, G. Fytas, and M. Montagna, “Eigenvibrations of submicrometer colloidal spheres,” J. Phys. Chem. Lett. 1(16), 2440–2444 (2010).
[Crossref]

Giugliarelli, A.

S. Caponi, L. Liguori, A. Giugliarelli, M. Mattarelli, A. Morresi, P. Sassi, L. Urbanelli, and C. Musio, “Raman micro-spectroscopy: a powerful tool for the monitoring of dynamic supramolecular changes in living cells,” Biophys. Chem. 182, 58–63 (2013).
[PubMed]

Hardis, R.

R. Hardis, J. L. P. Jessop, F. E. Peters, and M. R. Kessler, “Cure kinetics characterization and monitoring of an epoxy resin using DSC, Raman spectroscopy, and DEA,” Compos., Part A Appl. Sci. Manuf. 49, 100–108 (2013).
[Crossref]

Jessop, J. L. P.

R. Hardis, J. L. P. Jessop, F. E. Peters, and M. R. Kessler, “Cure kinetics characterization and monitoring of an epoxy resin using DSC, Raman spectroscopy, and DEA,” Compos., Part A Appl. Sci. Manuf. 49, 100–108 (2013).
[Crossref]

Jestin, Y.

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

Kalout, P.

G. Scarcelli, S. Besner, R. Pineda, P. Kalout, and S. H. Yun, “In vivo biomechanical mapping of normal and keratoconus corneas,” JAMA Ophthalmol. 133(4), 480–482 (2015).
[Crossref] [PubMed]

Kennedy, B. F.

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

Kenny, J. M.

S. Martino, F. D’Angelo, I. Armentano, J. M. Kenny, and A. Orlacchio, “Stem cell-biomaterial interactions for regenerative medicine,” Biotechnol. Adv. 30(1), 338–351 (2012).
[Crossref] [PubMed]

Kessler, M. R.

R. Hardis, J. L. P. Jessop, F. E. Peters, and M. R. Kessler, “Cure kinetics characterization and monitoring of an epoxy resin using DSC, Raman spectroscopy, and DEA,” Compos., Part A Appl. Sci. Manuf. 49, 100–108 (2013).
[Crossref]

Kiefer, D.

T. Still, M. Mattarelli, D. Kiefer, G. Fytas, and M. Montagna, “Eigenvibrations of submicrometer colloidal spheres,” J. Phys. Chem. Lett. 1(16), 2440–2444 (2010).
[Crossref]

Kim, B.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Kondiboyina, A.

G. Antonacci, R. M. Pedrigi, A. Kondiboyina, V. V. Mehta, R. de Silva, C. Paterson, R. Krams, and P. Török, “Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma,” J. R. Soc. Interface 12(112), 20150843 (2015).
[Crossref] [PubMed]

Krams, R.

G. Antonacci, R. M. Pedrigi, A. Kondiboyina, V. V. Mehta, R. de Silva, C. Paterson, R. Krams, and P. Török, “Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma,” J. R. Soc. Interface 12(112), 20150843 (2015).
[Crossref] [PubMed]

Larin, K. V.

Lekka, M.

M. Lekka, “Atomic force microscopy: A tip for diagnosing cancer,” Nat. Nanotechnol. 7(11), 691–692 (2012).

Liguori, L.

S. Caponi, L. Liguori, A. Giugliarelli, M. Mattarelli, A. Morresi, P. Sassi, L. Urbanelli, and C. Musio, “Raman micro-spectroscopy: a powerful tool for the monitoring of dynamic supramolecular changes in living cells,” Biophys. Chem. 182, 58–63 (2013).
[PubMed]

Litovitz, T.A.

C.J. Montrose, V.A Solovyev, and T.A. Litovitz, "Brillouin scattering and relaxation in liquids," The Journal of the Acoustical Society of America(1968).

Liu, H.

H. Liu and W. Yu, “Study of the structure transformation of wool fibers with Raman spectroscopy,” J. Appl. Polym. Sci. 103(1), 1–7 (2007).
[Crossref]

Madami, M.

F. Palombo, M. Madami, N. Stone, and D. Fioretto, “Mechanical mapping with chemical specificity by confocal Brillouin and Raman microscopy,” Analyst (Lond.) 139(4), 729–733 (2014).
[Crossref] [PubMed]

Martino, S.

S. Martino, F. D’Angelo, I. Armentano, J. M. Kenny, and A. Orlacchio, “Stem cell-biomaterial interactions for regenerative medicine,” Biotechnol. Adv. 30(1), 338–351 (2012).
[Crossref] [PubMed]

Mattana, S.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by micro-spectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref]

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, and F. Palombo, “Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis,” J. Innov. Opt. Health Sci. 10(6), 1742001 (2017).
[Crossref] [PubMed]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

S. Mattana, M. Alunni Cardinali, S. Caponi, D. Casagrande Pierantoni, L. Corte, L. Roscini, G. Cardinali, and D. Fioretto, “High-contrast Brillouin and Raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms,” Biophys. Chem. 229, 123–129 (2017).
[PubMed]

Mattarelli, M.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by micro-spectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref]

S. Caponi, S. Corezzi, M. Mattarelli, and D. Fioretto, “Stress effects on the elastic properties of amorphous polymeric materials,” J. Chem. Phys. 141(21), 214901 (2014).
[PubMed]

S. Caponi, L. Liguori, A. Giugliarelli, M. Mattarelli, A. Morresi, P. Sassi, L. Urbanelli, and C. Musio, “Raman micro-spectroscopy: a powerful tool for the monitoring of dynamic supramolecular changes in living cells,” Biophys. Chem. 182, 58–63 (2013).
[PubMed]

T. Still, M. Mattarelli, D. Kiefer, G. Fytas, and M. Montagna, “Eigenvibrations of submicrometer colloidal spheres,” J. Phys. Chem. Lett. 1(16), 2440–2444 (2010).
[Crossref]

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

McDonald, J.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Mehta, V. V.

G. Antonacci, R. M. Pedrigi, A. Kondiboyina, V. V. Mehta, R. de Silva, C. Paterson, R. Krams, and P. Török, “Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma,” J. R. Soc. Interface 12(112), 20150843 (2015).
[Crossref] [PubMed]

Meng, Z.

Z. Meng, A. J. Traverso, C. W. Ballmann, M. Troyanova-Wood, and V. V. Yakovlev, “Seeing cells in a new light: a renaissance of Brillouin spectroscopy,” Adv. Opt. Photonics 8(2), 300–327 (2016).
[Crossref]

Mezencev, R.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Montagna, M.

T. Still, M. Mattarelli, D. Kiefer, G. Fytas, and M. Montagna, “Eigenvibrations of submicrometer colloidal spheres,” J. Phys. Chem. Lett. 1(16), 2440–2444 (2010).
[Crossref]

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

Montrose, C.J.

C.J. Montrose, V.A Solovyev, and T.A. Litovitz, "Brillouin scattering and relaxation in liquids," The Journal of the Acoustical Society of America(1968).

Morresi, A.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

S. Caponi, L. Liguori, A. Giugliarelli, M. Mattarelli, A. Morresi, P. Sassi, L. Urbanelli, and C. Musio, “Raman micro-spectroscopy: a powerful tool for the monitoring of dynamic supramolecular changes in living cells,” Biophys. Chem. 182, 58–63 (2013).
[PubMed]

Moser, E.

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

Musio, C.

S. Caponi, L. Liguori, A. Giugliarelli, M. Mattarelli, A. Morresi, P. Sassi, L. Urbanelli, and C. Musio, “Raman micro-spectroscopy: a powerful tool for the monitoring of dynamic supramolecular changes in living cells,” Biophys. Chem. 182, 58–63 (2013).
[PubMed]

Mythreye, K.

V. Swaminathan, K. Mythreye, E. T. O’Brien, A. Berchuck, G. C. Blobe, and R. Superfine, “Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines,” Cancer Res. 71(15), 5075–5080 (2011).
[Crossref] [PubMed]

Nunzi Conti, G.

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

O’Brien, E. T.

V. Swaminathan, K. Mythreye, E. T. O’Brien, A. Berchuck, G. C. Blobe, and R. Superfine, “Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines,” Cancer Res. 71(15), 5075–5080 (2011).
[Crossref] [PubMed]

Orlacchio, A.

S. Martino, F. D’Angelo, I. Armentano, J. M. Kenny, and A. Orlacchio, “Stem cell-biomaterial interactions for regenerative medicine,” Biotechnol. Adv. 30(1), 338–351 (2012).
[Crossref] [PubMed]

Palombo, F.

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, and F. Palombo, “Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis,” J. Innov. Opt. Health Sci. 10(6), 1742001 (2017).
[Crossref] [PubMed]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

F. Palombo, M. Madami, N. Stone, and D. Fioretto, “Mechanical mapping with chemical specificity by confocal Brillouin and Raman microscopy,” Analyst (Lond.) 139(4), 729–733 (2014).
[Crossref] [PubMed]

Paolantoni, M.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

Paterson, C.

G. Antonacci, R. M. Pedrigi, A. Kondiboyina, V. V. Mehta, R. de Silva, C. Paterson, R. Krams, and P. Török, “Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma,” J. R. Soc. Interface 12(112), 20150843 (2015).
[Crossref] [PubMed]

Pedrigi, R. M.

G. Antonacci, R. M. Pedrigi, A. Kondiboyina, V. V. Mehta, R. de Silva, C. Paterson, R. Krams, and P. Török, “Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma,” J. R. Soc. Interface 12(112), 20150843 (2015).
[Crossref] [PubMed]

Pelli, S.

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

Peters, F. E.

R. Hardis, J. L. P. Jessop, F. E. Peters, and M. R. Kessler, “Cure kinetics characterization and monitoring of an epoxy resin using DSC, Raman spectroscopy, and DEA,” Compos., Part A Appl. Sci. Manuf. 49, 100–108 (2013).
[Crossref]

Phillip, J. M.

J. M. Phillip, I. Aifuwa, J. Walston, and D. Wirtz, “The Mechanobiology of Aging,” Annu. Rev. Biomed. Eng. 17(1), 113–141 (2015).
[Crossref] [PubMed]

Pilla, O.

S. Caponi, G. Carini, G. D’Angelo, A. Fontana, O. Pilla, F. Rossi, F. Terki, G. Tripodo, and T. Woignier, “Acoustic and thermal properties of silica aerogels and xerogels,” Phys. Rev. B 70(21), 214204 (2004).
[Crossref]

Pineda, R.

G. Scarcelli, S. Besner, R. Pineda, P. Kalout, and S. H. Yun, “In vivo biomechanical mapping of normal and keratoconus corneas,” JAMA Ophthalmol. 133(4), 480–482 (2015).
[Crossref] [PubMed]

G. Scarcelli, S. Besner, R. Pineda, and S. H. Yun, “Biomechanical characterization of keratoconus corneas ex vivo with Brillouin microscopy,” Invest. Ophthalmol. Vis. Sci. 55(7), 4490–4495 (2014).
[Crossref] [PubMed]

Righini, G. C.

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

Roscini, L.

S. Mattana, M. Alunni Cardinali, S. Caponi, D. Casagrande Pierantoni, L. Corte, L. Roscini, G. Cardinali, and D. Fioretto, “High-contrast Brillouin and Raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms,” Biophys. Chem. 229, 123–129 (2017).
[PubMed]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

Rossi, F.

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

S. Caponi, G. Carini, G. D’Angelo, A. Fontana, O. Pilla, F. Rossi, F. Terki, G. Tripodo, and T. Woignier, “Acoustic and thermal properties of silica aerogels and xerogels,” Phys. Rev. B 70(21), 214204 (2004).
[Crossref]

Sagini, K.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by micro-spectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref]

Sampson, D. D.

K. V. Larin and D. D. Sampson, “Optical coherence elastography - OCT at work in tissue biomechanics [Invited],” Biomed. Opt. Express 8(2), 1172–1202 (2017).
[Crossref] [PubMed]

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

Sandercock, J. R.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

Sassi, P.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

S. Caponi, L. Liguori, A. Giugliarelli, M. Mattarelli, A. Morresi, P. Sassi, L. Urbanelli, and C. Musio, “Raman micro-spectroscopy: a powerful tool for the monitoring of dynamic supramolecular changes in living cells,” Biophys. Chem. 182, 58–63 (2013).
[PubMed]

Scarcelli, G.

G. Scarcelli, S. Besner, R. Pineda, P. Kalout, and S. H. Yun, “In vivo biomechanical mapping of normal and keratoconus corneas,” JAMA Ophthalmol. 133(4), 480–482 (2015).
[Crossref] [PubMed]

G. Scarcelli, S. Besner, R. Pineda, and S. H. Yun, “Biomechanical characterization of keratoconus corneas ex vivo with Brillouin microscopy,” Invest. Ophthalmol. Vis. Sci. 55(7), 4490–4495 (2014).
[Crossref] [PubMed]

Scarponi, F.

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

Sen, S.

A. J. Engler, S. Sen, H. L. Sweeney, and D. E. Discher, “Matrix elasticity directs stem cell lineage specification,” Cell 126(4), 677–689 (2006).
[Crossref] [PubMed]

Serra, M. D.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by micro-spectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref]

Solovyev, V.A

C.J. Montrose, V.A Solovyev, and T.A. Litovitz, "Brillouin scattering and relaxation in liquids," The Journal of the Acoustical Society of America(1968).

Still, T.

T. Still, M. Mattarelli, D. Kiefer, G. Fytas, and M. Montagna, “Eigenvibrations of submicrometer colloidal spheres,” J. Phys. Chem. Lett. 1(16), 2440–2444 (2010).
[Crossref]

Stone, N.

F. Palombo, M. Madami, N. Stone, and D. Fioretto, “Mechanical mapping with chemical specificity by confocal Brillouin and Raman microscopy,” Analyst (Lond.) 139(4), 729–733 (2014).
[Crossref] [PubMed]

Sulchek, T.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Superfine, R.

V. Swaminathan, K. Mythreye, E. T. O’Brien, A. Berchuck, G. C. Blobe, and R. Superfine, “Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines,” Cancer Res. 71(15), 5075–5080 (2011).
[Crossref] [PubMed]

Swaminathan, V.

V. Swaminathan, K. Mythreye, E. T. O’Brien, A. Berchuck, G. C. Blobe, and R. Superfine, “Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines,” Cancer Res. 71(15), 5075–5080 (2011).
[Crossref] [PubMed]

Sweeney, H. L.

A. J. Engler, S. Sen, H. L. Sweeney, and D. E. Discher, “Matrix elasticity directs stem cell lineage specification,” Cell 126(4), 677–689 (2006).
[Crossref] [PubMed]

Tamagnini, F.

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, and F. Palombo, “Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis,” J. Innov. Opt. Health Sci. 10(6), 1742001 (2017).
[Crossref] [PubMed]

Terki, F.

S. Caponi, G. Carini, G. D’Angelo, A. Fontana, O. Pilla, F. Rossi, F. Terki, G. Tripodo, and T. Woignier, “Acoustic and thermal properties of silica aerogels and xerogels,” Phys. Rev. B 70(21), 214204 (2004).
[Crossref]

Török, P.

G. Antonacci, R. M. Pedrigi, A. Kondiboyina, V. V. Mehta, R. de Silva, C. Paterson, R. Krams, and P. Török, “Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma,” J. R. Soc. Interface 12(112), 20150843 (2015).
[Crossref] [PubMed]

Tosello, C.

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

Traverso, A. J.

Z. Meng, A. J. Traverso, C. W. Ballmann, M. Troyanova-Wood, and V. V. Yakovlev, “Seeing cells in a new light: a renaissance of Brillouin spectroscopy,” Adv. Opt. Photonics 8(2), 300–327 (2016).
[Crossref]

Tripodo, G.

S. Caponi, G. Carini, G. D’Angelo, A. Fontana, O. Pilla, F. Rossi, F. Terki, G. Tripodo, and T. Woignier, “Acoustic and thermal properties of silica aerogels and xerogels,” Phys. Rev. B 70(21), 214204 (2004).
[Crossref]

Troyanova-Wood, M.

Z. Meng, A. J. Traverso, C. W. Ballmann, M. Troyanova-Wood, and V. V. Yakovlev, “Seeing cells in a new light: a renaissance of Brillouin spectroscopy,” Adv. Opt. Photonics 8(2), 300–327 (2016).
[Crossref]

Urbanelli, L.

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by micro-spectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref]

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

S. Caponi, L. Liguori, A. Giugliarelli, M. Mattarelli, A. Morresi, P. Sassi, L. Urbanelli, and C. Musio, “Raman micro-spectroscopy: a powerful tool for the monitoring of dynamic supramolecular changes in living cells,” Biophys. Chem. 182, 58–63 (2013).
[PubMed]

Walston, J.

J. M. Phillip, I. Aifuwa, J. Walston, and D. Wirtz, “The Mechanobiology of Aging,” Annu. Rev. Biomed. Eng. 17(1), 113–141 (2015).
[Crossref] [PubMed]

Wang, L.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Wijesinghe, P.

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

Wirtz, D.

J. M. Phillip, I. Aifuwa, J. Walston, and D. Wirtz, “The Mechanobiology of Aging,” Annu. Rev. Biomed. Eng. 17(1), 113–141 (2015).
[Crossref] [PubMed]

Woignier, T.

S. Caponi, G. Carini, G. D’Angelo, A. Fontana, O. Pilla, F. Rossi, F. Terki, G. Tripodo, and T. Woignier, “Acoustic and thermal properties of silica aerogels and xerogels,” Phys. Rev. B 70(21), 214204 (2004).
[Crossref]

Xu, W.

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Yakovlev, V. V.

Z. Meng, A. J. Traverso, C. W. Ballmann, M. Troyanova-Wood, and V. V. Yakovlev, “Seeing cells in a new light: a renaissance of Brillouin spectroscopy,” Adv. Opt. Photonics 8(2), 300–327 (2016).
[Crossref]

Yu, W.

H. Liu and W. Yu, “Study of the structure transformation of wool fibers with Raman spectroscopy,” J. Appl. Polym. Sci. 103(1), 1–7 (2007).
[Crossref]

Yun, S. H.

G. Scarcelli, S. Besner, R. Pineda, P. Kalout, and S. H. Yun, “In vivo biomechanical mapping of normal and keratoconus corneas,” JAMA Ophthalmol. 133(4), 480–482 (2015).
[Crossref] [PubMed]

G. Scarcelli, S. Besner, R. Pineda, and S. H. Yun, “Biomechanical characterization of keratoconus corneas ex vivo with Brillouin microscopy,” Invest. Ophthalmol. Vis. Sci. 55(7), 4490–4495 (2014).
[Crossref] [PubMed]

Adv. Opt. Photonics (1)

Z. Meng, A. J. Traverso, C. W. Ballmann, M. Troyanova-Wood, and V. V. Yakovlev, “Seeing cells in a new light: a renaissance of Brillouin spectroscopy,” Adv. Opt. Photonics 8(2), 300–327 (2016).
[Crossref]

Advances in Physics: X (1)

C. E. Bottani and D. Fioretto, “Advances in Physics : X Brillouin scattering of phonons in complex materials,” Advances in Physics: X 6149, 1– 27 (2018).

Analyst (Lond.) (1)

F. Palombo, M. Madami, N. Stone, and D. Fioretto, “Mechanical mapping with chemical specificity by confocal Brillouin and Raman microscopy,” Analyst (Lond.) 139(4), 729–733 (2014).
[Crossref] [PubMed]

Annu. Rev. Biomed. Eng. (1)

J. M. Phillip, I. Aifuwa, J. Walston, and D. Wirtz, “The Mechanobiology of Aging,” Annu. Rev. Biomed. Eng. 17(1), 113–141 (2015).
[Crossref] [PubMed]

Biomed. Opt. Express (1)

Biophys. Chem. (2)

S. Caponi, L. Liguori, A. Giugliarelli, M. Mattarelli, A. Morresi, P. Sassi, L. Urbanelli, and C. Musio, “Raman micro-spectroscopy: a powerful tool for the monitoring of dynamic supramolecular changes in living cells,” Biophys. Chem. 182, 58–63 (2013).
[PubMed]

S. Mattana, M. Alunni Cardinali, S. Caponi, D. Casagrande Pierantoni, L. Corte, L. Roscini, G. Cardinali, and D. Fioretto, “High-contrast Brillouin and Raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms,” Biophys. Chem. 229, 123–129 (2017).
[PubMed]

Biotechnol. Adv. (1)

S. Martino, F. D’Angelo, I. Armentano, J. M. Kenny, and A. Orlacchio, “Stem cell-biomaterial interactions for regenerative medicine,” Biotechnol. Adv. 30(1), 338–351 (2012).
[Crossref] [PubMed]

Cancer Res. (1)

V. Swaminathan, K. Mythreye, E. T. O’Brien, A. Berchuck, G. C. Blobe, and R. Superfine, “Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines,” Cancer Res. 71(15), 5075–5080 (2011).
[Crossref] [PubMed]

Cell (1)

A. J. Engler, S. Sen, H. L. Sweeney, and D. E. Discher, “Matrix elasticity directs stem cell lineage specification,” Cell 126(4), 677–689 (2006).
[Crossref] [PubMed]

Compos., Part A Appl. Sci. Manuf. (1)

R. Hardis, J. L. P. Jessop, F. E. Peters, and M. R. Kessler, “Cure kinetics characterization and monitoring of an epoxy resin using DSC, Raman spectroscopy, and DEA,” Compos., Part A Appl. Sci. Manuf. 49, 100–108 (2013).
[Crossref]

Invest. Ophthalmol. Vis. Sci. (1)

G. Scarcelli, S. Besner, R. Pineda, and S. H. Yun, “Biomechanical characterization of keratoconus corneas ex vivo with Brillouin microscopy,” Invest. Ophthalmol. Vis. Sci. 55(7), 4490–4495 (2014).
[Crossref] [PubMed]

J. Appl. Polym. Sci. (1)

H. Liu and W. Yu, “Study of the structure transformation of wool fibers with Raman spectroscopy,” J. Appl. Polym. Sci. 103(1), 1–7 (2007).
[Crossref]

J. Chem. Phys. (1)

S. Caponi, S. Corezzi, M. Mattarelli, and D. Fioretto, “Stress effects on the elastic properties of amorphous polymeric materials,” J. Chem. Phys. 141(21), 214901 (2014).
[PubMed]

J. Innov. Opt. Health Sci. (1)

S. Mattana, S. Caponi, F. Tamagnini, D. Fioretto, and F. Palombo, “Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis,” J. Innov. Opt. Health Sci. 10(6), 1742001 (2017).
[Crossref] [PubMed]

J. Phys. Chem. Lett. (1)

T. Still, M. Mattarelli, D. Kiefer, G. Fytas, and M. Montagna, “Eigenvibrations of submicrometer colloidal spheres,” J. Phys. Chem. Lett. 1(16), 2440–2444 (2010).
[Crossref]

J. R. Soc. Interface (1)

G. Antonacci, R. M. Pedrigi, A. Kondiboyina, V. V. Mehta, R. de Silva, C. Paterson, R. Krams, and P. Török, “Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma,” J. R. Soc. Interface 12(112), 20150843 (2015).
[Crossref] [PubMed]

JAMA Ophthalmol. (1)

G. Scarcelli, S. Besner, R. Pineda, P. Kalout, and S. H. Yun, “In vivo biomechanical mapping of normal and keratoconus corneas,” JAMA Ophthalmol. 133(4), 480–482 (2015).
[Crossref] [PubMed]

Light Sci. Appl. (1)

S. Mattana, M. Mattarelli, L. Urbanelli, K. Sagini, C. Emiliani, M. D. Serra, D. Fioretto, and S. Caponi, “Non-contact mechanical and chemical analysis of single living cells by micro-spectroscopic techniques,” Light Sci. Appl. 7(2), 17139 (2018).
[Crossref]

Nat. Nanotechnol. (1)

M. Lekka, “Atomic force microscopy: A tip for diagnosing cancer,” Nat. Nanotechnol. 7(11), 691–692 (2012).

Nat. Photonics (1)

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

Optoelectron. Lett. (1)

M. Mattarelli, S. Caponi, A. Chiappini, M. Montagna, E. Moser, F. Rossi, C. Tosello, C. Armellini, A. Chiasera, M. Ferrari, Y. Jestin, G. Nunzi Conti, S. Pelli, and G. C. Righini, “Diagnostic techniques for photonic materials based on Raman and Brillouin spectroscopies,” Optoelectron. Lett. 3(3), 188–191 (2007).
[Crossref]

Phys. Rev. B (1)

S. Caponi, G. Carini, G. D’Angelo, A. Fontana, O. Pilla, F. Rossi, F. Terki, G. Tripodo, and T. Woignier, “Acoustic and thermal properties of silica aerogels and xerogels,” Phys. Rev. B 70(21), 214204 (2004).
[Crossref]

Phys. Rev. X (1)

F. Scarponi, S. Mattana, S. Corezzi, S. Caponi, L. Comez, P. Sassi, A. Morresi, M. Paolantoni, L. Urbanelli, C. Emiliani, L. Roscini, L. Corte, G. Cardinali, F. Palombo, J. R. Sandercock, and D. Fioretto, “High-performance versatile setup for simultaneous Brillouin-Raman microspectroscopy,” Phys. Rev. X 7(3), 031015 (2017).
[Crossref]

PLoS One (1)

W. Xu, R. Mezencev, B. Kim, L. Wang, J. McDonald, and T. Sulchek, “Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells,” PLoS One 7(10), e46609 (2012).
[Crossref] [PubMed]

Other (2)

C.J. Montrose, V.A Solovyev, and T.A. Litovitz, "Brillouin scattering and relaxation in liquids," The Journal of the Acoustical Society of America(1968).

W.H. Press, S.A. Teukolsky, W.T. Vetterling, and B.P. Flannery, Numerical Recipes in Fortran 77 - The Art Of Scientific Computing - Volume I (1992).

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Figures (2)

Fig. 1
Fig. 1 (a) Photomicrograph of wool fibers embedded into a 30 μm-thick epoxy film (DGEBA-DETA 5:2) mounted onto a reflecting silicon substrate. (b) Schematic diagram showing the focusing optics and scattering volumes for three points. (c) Brillouin spectra (left) and Raman spectra (right) extracted from the maps; they are color coded to the locations indicated in (a) and (b). (d) Raman map based on the normalized integrated intensity of the cysteine S–S band at 513 cm–1. (e) Brillouin map based on the average frequency shift (GHz) of the Brillouin peaks calculated from Eq. (1). (f) 3-D plot of ν ¯ mimicking the sample microstructure.
Fig. 2
Fig. 2 (a) Lorentzian curve with A = 102 counts·GHz (circles), ν0 = 7.6 GHz and Γ = 1GHz, together with fit results obtained using a Lavembergue-Marquardt minimization routine (red line), giving σ(ν0) = 0.01 GHz and σ(Α) = 2 counts·GHz. (b) Calculated (black crosses, Eq. (3)) and simulated (red squares) variances associated with the intensity and average frequency.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

I= i I i ; ν ¯ = i I i ν i I
σ 2 ( ν ¯ )= i ( ν ¯ I i ) 2 σ 2 ( I i )= i ( ν i ν ¯ I ) 2 σ 2 ( I i )
ν ¯ = i ( I 1i + I 2i ) ν i i I 1i + I 2i = I 1 ν ¯ 1 + I 2 ν ¯ 2 I 1 + I 2

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