Abstract

The visual evaluation of liver function (LF) has always been a hot topic in research on liver diseases. In vivo fluorescence imaging (IVFI) of the Cy5.5-galactosylated polylysine (Cy5.5-GP) probe targeting asialoglycoprotein receptor (ASGPR), for evaluating LF in chronic alcoholic liver injury (cALI) mice was investigated in this study. The decrease of fluorescence signals in the livers showed a biological relationship with the liver ASGPR expression, histology, and serum marker levels of LF in cALI mice. The targeted IVFI of ASGPR as a novel method can intuitively and noninvasively display the characteristics of liver’s ASGPR level to provide a reference for evaluating LF.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Full Article  |  PDF Article
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References

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    [Crossref]
  3. H. Y. Zhai, P. Liang, J. Yu, F. Cao, M. Kuang, F. Y. Liu, F. Y. Liu, and X. Y. Zhu, “Comparison of Sonazoid and Sonovue in the Diagnosis of Focal Liver Lesions: A Preliminary Study,” J. Ultrasound. Med. 38(9), 2417–2425 (2019).
    [Crossref]
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    [Crossref]
  5. R. K. Do, A. McErlean, C. S. Ang, R. P. DeMatteo, and G. K. Abou-Alfa, “CT and MRI of primary and metastatic fibrolamellar carcinoma: a case series of 37 patients,” Br. J. Radiol. 87(1040), 20140024 (2014).
    [Crossref]
  6. T. Hennedige and S. K. Venkatesh, “Imaging of hepatocellular carcinoma: diagnosis, staging and treatment monitoring,” Cancer Imaging. 12(3), 530–547 (2012).
    [Crossref]
  7. L. Petitclerc, G. Sebastiani, G. Gilbert, G. Cloutier, and A. Tang, “Liver fibrosis: Review of current imaging and MRI quantification techniques,” J. Magn. Reson. Imaging. 45(5), 1276–1295 (2017).
    [Crossref]
  8. K. Ozaki, S. Kobayashi, O. Matsui, T. Minami, W. Koda, and T. Gabata, “Extrahepatic Arteries Originating from Hepatic Arteries: Analysis Using CT During Hepatic Arteriography and Visualization on Digital Subtraction Angiography,” Cardiovasc. Intervent. Radiol. 40(6), 822–830 (2017).
    [Crossref]
  9. M. A. Khan, C. S. Combs, E. M. Brunt, V. J. Lowe, M. K. Wolverson, H. Solomon, B. T. Collins, and A. M. Di Bisceglie, “Positron emission tomography scanning in the evaluation of hepatocellular carcinoma,” J. Hepatol. 32(5), 792–797 (2000).
    [Crossref]
  10. D. Zhang, Z. Guo, P. Zhang, Y. Li, X. H. Su, L. Y. You, M. Gao, C. Liu, H. Wu, and X. Z. Zhang, “Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with (99 m)Tc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice,” Sci. Rep. 6(1), 25377 (2016).
    [Crossref]
  11. H.W. Lee, P. G angadaran, S. Kalimuthu, and A. Byeong-Cheol, “Advances in Molecular Imaging Strategies for In Vivo Tracking of Immune Cells,” BioMed Res. Int. 2016, 1946585 (2016).
    [Crossref]
  12. M. Furuya and M. Ishii, “Frontiers in live bone imaging researches. In vivo imaging of osteoblasts,” Clin. Calcium. 25(6), 823–830 (2015).
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  14. D. Villalta, M. G. Mytilinaiou, M. Elsner, C. Hentschel, J. Cuccato, V. Somma, P. Schierack, D. Roggenbuck, and D. P. Bogdanos, “Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases,” Clin. Chim. Acta 450, 1–5 (2015).
    [Crossref]
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    [Crossref]
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    [Crossref]
  17. Z. Ke, J. Li, J. Zhe, L. B. Liang, L. Yan, and M. Yi, “Flow cytometric analysis of asialoglycoprotein receptor expression predicts hepatic functional reserve after hepatectomy,” J. Coll. Physicians. Surg. Pak. 24(11), 820–824 (2014).
  18. W. Jing, J. Li, L. Q. Tao, J. Zhe, L. B. Liang, and Z. Ke, “Prediction of asialoglycoprotein receptors by correlated liver function parameters before hepatectomy,” J. Pak. Med. Assoc. 66(Suppl 3), S56–S58 (2016).
  19. M. Matsumoto, I. Cyganek, P. C. Sanghani, W. K. Cho, S. Liangpunsakul, and D. W. Crabb, “Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration,” Alcohol.: Clin. Exp. Res. 35(1), 28–38 (2011).
    [Crossref]
  20. T. Radosavljević, D. Mladenović, and D. Vucević, “The role of oxidative stress in alcoholic liver injury,” Med. Pregl. 62(11-12), 547–553 (2009).
    [Crossref]
  21. D. Zhang, X.J. Song, S.Y. Li, S.Y. Wang, B.J. Chen, X.D. Bai, and L.M. Tang, “Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods,” Sci. Rep. 6(1), 30119 (2016).
    [Crossref]
  22. G. Szabo, B. Saha, and T. N. Bukong, “Alcohol and HCV: implications for liver cancer,” Adv. Exp. Med. Biol. 815, 197–216 (2015).
    [Crossref]
  23. V. Ntziachristos and D. Razansky, “Optical and opto-acoustic imaging,” Recent Results Cancer Res. 187, 133–150 (2013).
    [Crossref]
  24. H. Y. Zhang, O. H. Aina, K. S. Lam, R. de Vere White, E. Christopher, H. Paul, P. N. Lara, X. Wang, J. A. Bassuk, and C. X. Pan, “Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach,” Urol. Oncol. 30(5), 635–645 (2012).
    [Crossref]
  25. W. Han, R. Zaynagetdinov, F. E. Yull, V. V. Polosukhin, L. A. Gleaves, and H. Tanjore, “Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation,” Am. J. Respir. Cell Mol. Biol. 53(1), 50–59 (2015).
    [Crossref]

2019 (1)

H. Y. Zhai, P. Liang, J. Yu, F. Cao, M. Kuang, F. Y. Liu, F. Y. Liu, and X. Y. Zhu, “Comparison of Sonazoid and Sonovue in the Diagnosis of Focal Liver Lesions: A Preliminary Study,” J. Ultrasound. Med. 38(9), 2417–2425 (2019).
[Crossref]

2017 (2)

L. Petitclerc, G. Sebastiani, G. Gilbert, G. Cloutier, and A. Tang, “Liver fibrosis: Review of current imaging and MRI quantification techniques,” J. Magn. Reson. Imaging. 45(5), 1276–1295 (2017).
[Crossref]

K. Ozaki, S. Kobayashi, O. Matsui, T. Minami, W. Koda, and T. Gabata, “Extrahepatic Arteries Originating from Hepatic Arteries: Analysis Using CT During Hepatic Arteriography and Visualization on Digital Subtraction Angiography,” Cardiovasc. Intervent. Radiol. 40(6), 822–830 (2017).
[Crossref]

2016 (4)

D. Zhang, Z. Guo, P. Zhang, Y. Li, X. H. Su, L. Y. You, M. Gao, C. Liu, H. Wu, and X. Z. Zhang, “Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with (99 m)Tc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice,” Sci. Rep. 6(1), 25377 (2016).
[Crossref]

H.W. Lee, P. G angadaran, S. Kalimuthu, and A. Byeong-Cheol, “Advances in Molecular Imaging Strategies for In Vivo Tracking of Immune Cells,” BioMed Res. Int. 2016, 1946585 (2016).
[Crossref]

D. Zhang, X.J. Song, S.Y. Li, S.Y. Wang, B.J. Chen, X.D. Bai, and L.M. Tang, “Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods,” Sci. Rep. 6(1), 30119 (2016).
[Crossref]

W. Jing, J. Li, L. Q. Tao, J. Zhe, L. B. Liang, and Z. Ke, “Prediction of asialoglycoprotein receptors by correlated liver function parameters before hepatectomy,” J. Pak. Med. Assoc. 66(Suppl 3), S56–S58 (2016).

2015 (4)

W. Han, R. Zaynagetdinov, F. E. Yull, V. V. Polosukhin, L. A. Gleaves, and H. Tanjore, “Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation,” Am. J. Respir. Cell Mol. Biol. 53(1), 50–59 (2015).
[Crossref]

G. Szabo, B. Saha, and T. N. Bukong, “Alcohol and HCV: implications for liver cancer,” Adv. Exp. Med. Biol. 815, 197–216 (2015).
[Crossref]

M. Furuya and M. Ishii, “Frontiers in live bone imaging researches. In vivo imaging of osteoblasts,” Clin. Calcium. 25(6), 823–830 (2015).

D. Villalta, M. G. Mytilinaiou, M. Elsner, C. Hentschel, J. Cuccato, V. Somma, P. Schierack, D. Roggenbuck, and D. P. Bogdanos, “Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases,” Clin. Chim. Acta 450, 1–5 (2015).
[Crossref]

2014 (4)

B. L. McVicker, G. M. Thiele, D. J. Tuma, and C. A. Casey, “Hepatocyte-mediated cytotoxicity and host defense mechanisms in the alcohol-injured liver,” Hepatol. Int. 8(S2), 432–438 (2014).
[Crossref]

J. Hu, J. Liu, D. Yang, M. Lu, and J. Yin, “Physiological roles of asialoglycoprotein receptors (ASGPRs) variants and recent advances in hepatic-targeted delivery of therapeutic molecules via ASGPRs,” Protein Pept. Lett. 21(10), 1025–1030 (2014).
[Crossref]

Z. Ke, J. Li, J. Zhe, L. B. Liang, L. Yan, and M. Yi, “Flow cytometric analysis of asialoglycoprotein receptor expression predicts hepatic functional reserve after hepatectomy,” J. Coll. Physicians. Surg. Pak. 24(11), 820–824 (2014).

R. K. Do, A. McErlean, C. S. Ang, R. P. DeMatteo, and G. K. Abou-Alfa, “CT and MRI of primary and metastatic fibrolamellar carcinoma: a case series of 37 patients,” Br. J. Radiol. 87(1040), 20140024 (2014).
[Crossref]

2013 (2)

A. Bertola, S. Mathews, S. H. Ki, H. Wang, and B. Gao, “Mouse model of chronic and binge ethanol feeding (the NIAAA model),” Nat. Protoc. 8(3), 627–637 (2013).
[Crossref]

V. Ntziachristos and D. Razansky, “Optical and opto-acoustic imaging,” Recent Results Cancer Res. 187, 133–150 (2013).
[Crossref]

2012 (2)

H. Y. Zhang, O. H. Aina, K. S. Lam, R. de Vere White, E. Christopher, H. Paul, P. N. Lara, X. Wang, J. A. Bassuk, and C. X. Pan, “Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach,” Urol. Oncol. 30(5), 635–645 (2012).
[Crossref]

T. Hennedige and S. K. Venkatesh, “Imaging of hepatocellular carcinoma: diagnosis, staging and treatment monitoring,” Cancer Imaging. 12(3), 530–547 (2012).
[Crossref]

2011 (1)

M. Matsumoto, I. Cyganek, P. C. Sanghani, W. K. Cho, S. Liangpunsakul, and D. W. Crabb, “Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration,” Alcohol.: Clin. Exp. Res. 35(1), 28–38 (2011).
[Crossref]

2009 (1)

T. Radosavljević, D. Mladenović, and D. Vucević, “The role of oxidative stress in alcoholic liver injury,” Med. Pregl. 62(11-12), 547–553 (2009).
[Crossref]

2007 (1)

S. G. Sakka, “Assessing liver function,” Curr. Opin. Crit. Care. 13(2), 207–214 (2007).
[Crossref]

2006 (1)

S. R. Wilson and P. N. Burns, “An algorithm for the diagnosis of focal liver masses using microbubble contrast-enhanced pulse-inversion sonography,” AJR, Am. J. Roentgenol. 186(5), 1401–1412 (2006).
[Crossref]

2003 (1)

S. Amano, M. Ebara, T. Yajima, H. Fukuda, M. Yoshikawa, N. Sugiura, K. Kato, F. Kondo, T. Matsumoto, and H. Saisho, “Assessment of cancer cell differentiation in small hepatocellular carcinoma by computed tomography and magnetic resonance imaging,” J. Gastroenterol. Hepatol. 18(3), 273–279 (2003).
[Crossref]

2000 (1)

M. A. Khan, C. S. Combs, E. M. Brunt, V. J. Lowe, M. K. Wolverson, H. Solomon, B. T. Collins, and A. M. Di Bisceglie, “Positron emission tomography scanning in the evaluation of hepatocellular carcinoma,” J. Hepatol. 32(5), 792–797 (2000).
[Crossref]

Abou-Alfa, G. K.

R. K. Do, A. McErlean, C. S. Ang, R. P. DeMatteo, and G. K. Abou-Alfa, “CT and MRI of primary and metastatic fibrolamellar carcinoma: a case series of 37 patients,” Br. J. Radiol. 87(1040), 20140024 (2014).
[Crossref]

Aina, O. H.

H. Y. Zhang, O. H. Aina, K. S. Lam, R. de Vere White, E. Christopher, H. Paul, P. N. Lara, X. Wang, J. A. Bassuk, and C. X. Pan, “Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach,” Urol. Oncol. 30(5), 635–645 (2012).
[Crossref]

Amano, S.

S. Amano, M. Ebara, T. Yajima, H. Fukuda, M. Yoshikawa, N. Sugiura, K. Kato, F. Kondo, T. Matsumoto, and H. Saisho, “Assessment of cancer cell differentiation in small hepatocellular carcinoma by computed tomography and magnetic resonance imaging,” J. Gastroenterol. Hepatol. 18(3), 273–279 (2003).
[Crossref]

Ang, C. S.

R. K. Do, A. McErlean, C. S. Ang, R. P. DeMatteo, and G. K. Abou-Alfa, “CT and MRI of primary and metastatic fibrolamellar carcinoma: a case series of 37 patients,” Br. J. Radiol. 87(1040), 20140024 (2014).
[Crossref]

angadaran, P. G

H.W. Lee, P. G angadaran, S. Kalimuthu, and A. Byeong-Cheol, “Advances in Molecular Imaging Strategies for In Vivo Tracking of Immune Cells,” BioMed Res. Int. 2016, 1946585 (2016).
[Crossref]

Bai, X.D.

D. Zhang, X.J. Song, S.Y. Li, S.Y. Wang, B.J. Chen, X.D. Bai, and L.M. Tang, “Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods,” Sci. Rep. 6(1), 30119 (2016).
[Crossref]

Bassuk, J. A.

H. Y. Zhang, O. H. Aina, K. S. Lam, R. de Vere White, E. Christopher, H. Paul, P. N. Lara, X. Wang, J. A. Bassuk, and C. X. Pan, “Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach,” Urol. Oncol. 30(5), 635–645 (2012).
[Crossref]

Bertola, A.

A. Bertola, S. Mathews, S. H. Ki, H. Wang, and B. Gao, “Mouse model of chronic and binge ethanol feeding (the NIAAA model),” Nat. Protoc. 8(3), 627–637 (2013).
[Crossref]

Bogdanos, D. P.

D. Villalta, M. G. Mytilinaiou, M. Elsner, C. Hentschel, J. Cuccato, V. Somma, P. Schierack, D. Roggenbuck, and D. P. Bogdanos, “Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases,” Clin. Chim. Acta 450, 1–5 (2015).
[Crossref]

Brunt, E. M.

M. A. Khan, C. S. Combs, E. M. Brunt, V. J. Lowe, M. K. Wolverson, H. Solomon, B. T. Collins, and A. M. Di Bisceglie, “Positron emission tomography scanning in the evaluation of hepatocellular carcinoma,” J. Hepatol. 32(5), 792–797 (2000).
[Crossref]

Bukong, T. N.

G. Szabo, B. Saha, and T. N. Bukong, “Alcohol and HCV: implications for liver cancer,” Adv. Exp. Med. Biol. 815, 197–216 (2015).
[Crossref]

Burns, P. N.

S. R. Wilson and P. N. Burns, “An algorithm for the diagnosis of focal liver masses using microbubble contrast-enhanced pulse-inversion sonography,” AJR, Am. J. Roentgenol. 186(5), 1401–1412 (2006).
[Crossref]

Byeong-Cheol, A.

H.W. Lee, P. G angadaran, S. Kalimuthu, and A. Byeong-Cheol, “Advances in Molecular Imaging Strategies for In Vivo Tracking of Immune Cells,” BioMed Res. Int. 2016, 1946585 (2016).
[Crossref]

Cao, F.

H. Y. Zhai, P. Liang, J. Yu, F. Cao, M. Kuang, F. Y. Liu, F. Y. Liu, and X. Y. Zhu, “Comparison of Sonazoid and Sonovue in the Diagnosis of Focal Liver Lesions: A Preliminary Study,” J. Ultrasound. Med. 38(9), 2417–2425 (2019).
[Crossref]

Casey, C. A.

B. L. McVicker, G. M. Thiele, D. J. Tuma, and C. A. Casey, “Hepatocyte-mediated cytotoxicity and host defense mechanisms in the alcohol-injured liver,” Hepatol. Int. 8(S2), 432–438 (2014).
[Crossref]

Chen, B.J.

D. Zhang, X.J. Song, S.Y. Li, S.Y. Wang, B.J. Chen, X.D. Bai, and L.M. Tang, “Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods,” Sci. Rep. 6(1), 30119 (2016).
[Crossref]

Cho, W. K.

M. Matsumoto, I. Cyganek, P. C. Sanghani, W. K. Cho, S. Liangpunsakul, and D. W. Crabb, “Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration,” Alcohol.: Clin. Exp. Res. 35(1), 28–38 (2011).
[Crossref]

Christopher, E.

H. Y. Zhang, O. H. Aina, K. S. Lam, R. de Vere White, E. Christopher, H. Paul, P. N. Lara, X. Wang, J. A. Bassuk, and C. X. Pan, “Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach,” Urol. Oncol. 30(5), 635–645 (2012).
[Crossref]

Cloutier, G.

L. Petitclerc, G. Sebastiani, G. Gilbert, G. Cloutier, and A. Tang, “Liver fibrosis: Review of current imaging and MRI quantification techniques,” J. Magn. Reson. Imaging. 45(5), 1276–1295 (2017).
[Crossref]

Collins, B. T.

M. A. Khan, C. S. Combs, E. M. Brunt, V. J. Lowe, M. K. Wolverson, H. Solomon, B. T. Collins, and A. M. Di Bisceglie, “Positron emission tomography scanning in the evaluation of hepatocellular carcinoma,” J. Hepatol. 32(5), 792–797 (2000).
[Crossref]

Combs, C. S.

M. A. Khan, C. S. Combs, E. M. Brunt, V. J. Lowe, M. K. Wolverson, H. Solomon, B. T. Collins, and A. M. Di Bisceglie, “Positron emission tomography scanning in the evaluation of hepatocellular carcinoma,” J. Hepatol. 32(5), 792–797 (2000).
[Crossref]

Crabb, D. W.

M. Matsumoto, I. Cyganek, P. C. Sanghani, W. K. Cho, S. Liangpunsakul, and D. W. Crabb, “Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration,” Alcohol.: Clin. Exp. Res. 35(1), 28–38 (2011).
[Crossref]

Cuccato, J.

D. Villalta, M. G. Mytilinaiou, M. Elsner, C. Hentschel, J. Cuccato, V. Somma, P. Schierack, D. Roggenbuck, and D. P. Bogdanos, “Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases,” Clin. Chim. Acta 450, 1–5 (2015).
[Crossref]

Cyganek, I.

M. Matsumoto, I. Cyganek, P. C. Sanghani, W. K. Cho, S. Liangpunsakul, and D. W. Crabb, “Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration,” Alcohol.: Clin. Exp. Res. 35(1), 28–38 (2011).
[Crossref]

de Vere White, R.

H. Y. Zhang, O. H. Aina, K. S. Lam, R. de Vere White, E. Christopher, H. Paul, P. N. Lara, X. Wang, J. A. Bassuk, and C. X. Pan, “Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach,” Urol. Oncol. 30(5), 635–645 (2012).
[Crossref]

DeMatteo, R. P.

R. K. Do, A. McErlean, C. S. Ang, R. P. DeMatteo, and G. K. Abou-Alfa, “CT and MRI of primary and metastatic fibrolamellar carcinoma: a case series of 37 patients,” Br. J. Radiol. 87(1040), 20140024 (2014).
[Crossref]

Di Bisceglie, A. M.

M. A. Khan, C. S. Combs, E. M. Brunt, V. J. Lowe, M. K. Wolverson, H. Solomon, B. T. Collins, and A. M. Di Bisceglie, “Positron emission tomography scanning in the evaluation of hepatocellular carcinoma,” J. Hepatol. 32(5), 792–797 (2000).
[Crossref]

Do, R. K.

R. K. Do, A. McErlean, C. S. Ang, R. P. DeMatteo, and G. K. Abou-Alfa, “CT and MRI of primary and metastatic fibrolamellar carcinoma: a case series of 37 patients,” Br. J. Radiol. 87(1040), 20140024 (2014).
[Crossref]

Ebara, M.

S. Amano, M. Ebara, T. Yajima, H. Fukuda, M. Yoshikawa, N. Sugiura, K. Kato, F. Kondo, T. Matsumoto, and H. Saisho, “Assessment of cancer cell differentiation in small hepatocellular carcinoma by computed tomography and magnetic resonance imaging,” J. Gastroenterol. Hepatol. 18(3), 273–279 (2003).
[Crossref]

Elsner, M.

D. Villalta, M. G. Mytilinaiou, M. Elsner, C. Hentschel, J. Cuccato, V. Somma, P. Schierack, D. Roggenbuck, and D. P. Bogdanos, “Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases,” Clin. Chim. Acta 450, 1–5 (2015).
[Crossref]

Fukuda, H.

S. Amano, M. Ebara, T. Yajima, H. Fukuda, M. Yoshikawa, N. Sugiura, K. Kato, F. Kondo, T. Matsumoto, and H. Saisho, “Assessment of cancer cell differentiation in small hepatocellular carcinoma by computed tomography and magnetic resonance imaging,” J. Gastroenterol. Hepatol. 18(3), 273–279 (2003).
[Crossref]

Furuya, M.

M. Furuya and M. Ishii, “Frontiers in live bone imaging researches. In vivo imaging of osteoblasts,” Clin. Calcium. 25(6), 823–830 (2015).

Gabata, T.

K. Ozaki, S. Kobayashi, O. Matsui, T. Minami, W. Koda, and T. Gabata, “Extrahepatic Arteries Originating from Hepatic Arteries: Analysis Using CT During Hepatic Arteriography and Visualization on Digital Subtraction Angiography,” Cardiovasc. Intervent. Radiol. 40(6), 822–830 (2017).
[Crossref]

Gao, B.

A. Bertola, S. Mathews, S. H. Ki, H. Wang, and B. Gao, “Mouse model of chronic and binge ethanol feeding (the NIAAA model),” Nat. Protoc. 8(3), 627–637 (2013).
[Crossref]

Gao, M.

D. Zhang, Z. Guo, P. Zhang, Y. Li, X. H. Su, L. Y. You, M. Gao, C. Liu, H. Wu, and X. Z. Zhang, “Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with (99 m)Tc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice,” Sci. Rep. 6(1), 25377 (2016).
[Crossref]

Gilbert, G.

L. Petitclerc, G. Sebastiani, G. Gilbert, G. Cloutier, and A. Tang, “Liver fibrosis: Review of current imaging and MRI quantification techniques,” J. Magn. Reson. Imaging. 45(5), 1276–1295 (2017).
[Crossref]

Gleaves, L. A.

W. Han, R. Zaynagetdinov, F. E. Yull, V. V. Polosukhin, L. A. Gleaves, and H. Tanjore, “Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation,” Am. J. Respir. Cell Mol. Biol. 53(1), 50–59 (2015).
[Crossref]

Guo, Z.

D. Zhang, Z. Guo, P. Zhang, Y. Li, X. H. Su, L. Y. You, M. Gao, C. Liu, H. Wu, and X. Z. Zhang, “Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with (99 m)Tc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice,” Sci. Rep. 6(1), 25377 (2016).
[Crossref]

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W. Han, R. Zaynagetdinov, F. E. Yull, V. V. Polosukhin, L. A. Gleaves, and H. Tanjore, “Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation,” Am. J. Respir. Cell Mol. Biol. 53(1), 50–59 (2015).
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T. Hennedige and S. K. Venkatesh, “Imaging of hepatocellular carcinoma: diagnosis, staging and treatment monitoring,” Cancer Imaging. 12(3), 530–547 (2012).
[Crossref]

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D. Villalta, M. G. Mytilinaiou, M. Elsner, C. Hentschel, J. Cuccato, V. Somma, P. Schierack, D. Roggenbuck, and D. P. Bogdanos, “Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases,” Clin. Chim. Acta 450, 1–5 (2015).
[Crossref]

Hu, J.

J. Hu, J. Liu, D. Yang, M. Lu, and J. Yin, “Physiological roles of asialoglycoprotein receptors (ASGPRs) variants and recent advances in hepatic-targeted delivery of therapeutic molecules via ASGPRs,” Protein Pept. Lett. 21(10), 1025–1030 (2014).
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M. Furuya and M. Ishii, “Frontiers in live bone imaging researches. In vivo imaging of osteoblasts,” Clin. Calcium. 25(6), 823–830 (2015).

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W. Jing, J. Li, L. Q. Tao, J. Zhe, L. B. Liang, and Z. Ke, “Prediction of asialoglycoprotein receptors by correlated liver function parameters before hepatectomy,” J. Pak. Med. Assoc. 66(Suppl 3), S56–S58 (2016).

Kalimuthu, S.

H.W. Lee, P. G angadaran, S. Kalimuthu, and A. Byeong-Cheol, “Advances in Molecular Imaging Strategies for In Vivo Tracking of Immune Cells,” BioMed Res. Int. 2016, 1946585 (2016).
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S. Amano, M. Ebara, T. Yajima, H. Fukuda, M. Yoshikawa, N. Sugiura, K. Kato, F. Kondo, T. Matsumoto, and H. Saisho, “Assessment of cancer cell differentiation in small hepatocellular carcinoma by computed tomography and magnetic resonance imaging,” J. Gastroenterol. Hepatol. 18(3), 273–279 (2003).
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W. Jing, J. Li, L. Q. Tao, J. Zhe, L. B. Liang, and Z. Ke, “Prediction of asialoglycoprotein receptors by correlated liver function parameters before hepatectomy,” J. Pak. Med. Assoc. 66(Suppl 3), S56–S58 (2016).

Z. Ke, J. Li, J. Zhe, L. B. Liang, L. Yan, and M. Yi, “Flow cytometric analysis of asialoglycoprotein receptor expression predicts hepatic functional reserve after hepatectomy,” J. Coll. Physicians. Surg. Pak. 24(11), 820–824 (2014).

Khan, M. A.

M. A. Khan, C. S. Combs, E. M. Brunt, V. J. Lowe, M. K. Wolverson, H. Solomon, B. T. Collins, and A. M. Di Bisceglie, “Positron emission tomography scanning in the evaluation of hepatocellular carcinoma,” J. Hepatol. 32(5), 792–797 (2000).
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A. Bertola, S. Mathews, S. H. Ki, H. Wang, and B. Gao, “Mouse model of chronic and binge ethanol feeding (the NIAAA model),” Nat. Protoc. 8(3), 627–637 (2013).
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K. Ozaki, S. Kobayashi, O. Matsui, T. Minami, W. Koda, and T. Gabata, “Extrahepatic Arteries Originating from Hepatic Arteries: Analysis Using CT During Hepatic Arteriography and Visualization on Digital Subtraction Angiography,” Cardiovasc. Intervent. Radiol. 40(6), 822–830 (2017).
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K. Ozaki, S. Kobayashi, O. Matsui, T. Minami, W. Koda, and T. Gabata, “Extrahepatic Arteries Originating from Hepatic Arteries: Analysis Using CT During Hepatic Arteriography and Visualization on Digital Subtraction Angiography,” Cardiovasc. Intervent. Radiol. 40(6), 822–830 (2017).
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S. Amano, M. Ebara, T. Yajima, H. Fukuda, M. Yoshikawa, N. Sugiura, K. Kato, F. Kondo, T. Matsumoto, and H. Saisho, “Assessment of cancer cell differentiation in small hepatocellular carcinoma by computed tomography and magnetic resonance imaging,” J. Gastroenterol. Hepatol. 18(3), 273–279 (2003).
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H. Y. Zhai, P. Liang, J. Yu, F. Cao, M. Kuang, F. Y. Liu, F. Y. Liu, and X. Y. Zhu, “Comparison of Sonazoid and Sonovue in the Diagnosis of Focal Liver Lesions: A Preliminary Study,” J. Ultrasound. Med. 38(9), 2417–2425 (2019).
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H. Y. Zhang, O. H. Aina, K. S. Lam, R. de Vere White, E. Christopher, H. Paul, P. N. Lara, X. Wang, J. A. Bassuk, and C. X. Pan, “Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach,” Urol. Oncol. 30(5), 635–645 (2012).
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H. Y. Zhang, O. H. Aina, K. S. Lam, R. de Vere White, E. Christopher, H. Paul, P. N. Lara, X. Wang, J. A. Bassuk, and C. X. Pan, “Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach,” Urol. Oncol. 30(5), 635–645 (2012).
[Crossref]

Lee, H.W.

H.W. Lee, P. G angadaran, S. Kalimuthu, and A. Byeong-Cheol, “Advances in Molecular Imaging Strategies for In Vivo Tracking of Immune Cells,” BioMed Res. Int. 2016, 1946585 (2016).
[Crossref]

Li, J.

W. Jing, J. Li, L. Q. Tao, J. Zhe, L. B. Liang, and Z. Ke, “Prediction of asialoglycoprotein receptors by correlated liver function parameters before hepatectomy,” J. Pak. Med. Assoc. 66(Suppl 3), S56–S58 (2016).

Z. Ke, J. Li, J. Zhe, L. B. Liang, L. Yan, and M. Yi, “Flow cytometric analysis of asialoglycoprotein receptor expression predicts hepatic functional reserve after hepatectomy,” J. Coll. Physicians. Surg. Pak. 24(11), 820–824 (2014).

Li, S.Y.

D. Zhang, X.J. Song, S.Y. Li, S.Y. Wang, B.J. Chen, X.D. Bai, and L.M. Tang, “Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods,” Sci. Rep. 6(1), 30119 (2016).
[Crossref]

Li, Y.

D. Zhang, Z. Guo, P. Zhang, Y. Li, X. H. Su, L. Y. You, M. Gao, C. Liu, H. Wu, and X. Z. Zhang, “Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with (99 m)Tc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice,” Sci. Rep. 6(1), 25377 (2016).
[Crossref]

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W. Jing, J. Li, L. Q. Tao, J. Zhe, L. B. Liang, and Z. Ke, “Prediction of asialoglycoprotein receptors by correlated liver function parameters before hepatectomy,” J. Pak. Med. Assoc. 66(Suppl 3), S56–S58 (2016).

Z. Ke, J. Li, J. Zhe, L. B. Liang, L. Yan, and M. Yi, “Flow cytometric analysis of asialoglycoprotein receptor expression predicts hepatic functional reserve after hepatectomy,” J. Coll. Physicians. Surg. Pak. 24(11), 820–824 (2014).

Liang, P.

H. Y. Zhai, P. Liang, J. Yu, F. Cao, M. Kuang, F. Y. Liu, F. Y. Liu, and X. Y. Zhu, “Comparison of Sonazoid and Sonovue in the Diagnosis of Focal Liver Lesions: A Preliminary Study,” J. Ultrasound. Med. 38(9), 2417–2425 (2019).
[Crossref]

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M. Matsumoto, I. Cyganek, P. C. Sanghani, W. K. Cho, S. Liangpunsakul, and D. W. Crabb, “Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration,” Alcohol.: Clin. Exp. Res. 35(1), 28–38 (2011).
[Crossref]

Liu, C.

D. Zhang, Z. Guo, P. Zhang, Y. Li, X. H. Su, L. Y. You, M. Gao, C. Liu, H. Wu, and X. Z. Zhang, “Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with (99 m)Tc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice,” Sci. Rep. 6(1), 25377 (2016).
[Crossref]

Liu, F. Y.

H. Y. Zhai, P. Liang, J. Yu, F. Cao, M. Kuang, F. Y. Liu, F. Y. Liu, and X. Y. Zhu, “Comparison of Sonazoid and Sonovue in the Diagnosis of Focal Liver Lesions: A Preliminary Study,” J. Ultrasound. Med. 38(9), 2417–2425 (2019).
[Crossref]

H. Y. Zhai, P. Liang, J. Yu, F. Cao, M. Kuang, F. Y. Liu, F. Y. Liu, and X. Y. Zhu, “Comparison of Sonazoid and Sonovue in the Diagnosis of Focal Liver Lesions: A Preliminary Study,” J. Ultrasound. Med. 38(9), 2417–2425 (2019).
[Crossref]

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J. Hu, J. Liu, D. Yang, M. Lu, and J. Yin, “Physiological roles of asialoglycoprotein receptors (ASGPRs) variants and recent advances in hepatic-targeted delivery of therapeutic molecules via ASGPRs,” Protein Pept. Lett. 21(10), 1025–1030 (2014).
[Crossref]

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M. A. Khan, C. S. Combs, E. M. Brunt, V. J. Lowe, M. K. Wolverson, H. Solomon, B. T. Collins, and A. M. Di Bisceglie, “Positron emission tomography scanning in the evaluation of hepatocellular carcinoma,” J. Hepatol. 32(5), 792–797 (2000).
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Lu, M.

J. Hu, J. Liu, D. Yang, M. Lu, and J. Yin, “Physiological roles of asialoglycoprotein receptors (ASGPRs) variants and recent advances in hepatic-targeted delivery of therapeutic molecules via ASGPRs,” Protein Pept. Lett. 21(10), 1025–1030 (2014).
[Crossref]

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A. Bertola, S. Mathews, S. H. Ki, H. Wang, and B. Gao, “Mouse model of chronic and binge ethanol feeding (the NIAAA model),” Nat. Protoc. 8(3), 627–637 (2013).
[Crossref]

Matsui, O.

K. Ozaki, S. Kobayashi, O. Matsui, T. Minami, W. Koda, and T. Gabata, “Extrahepatic Arteries Originating from Hepatic Arteries: Analysis Using CT During Hepatic Arteriography and Visualization on Digital Subtraction Angiography,” Cardiovasc. Intervent. Radiol. 40(6), 822–830 (2017).
[Crossref]

Matsumoto, M.

M. Matsumoto, I. Cyganek, P. C. Sanghani, W. K. Cho, S. Liangpunsakul, and D. W. Crabb, “Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration,” Alcohol.: Clin. Exp. Res. 35(1), 28–38 (2011).
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Matsumoto, T.

S. Amano, M. Ebara, T. Yajima, H. Fukuda, M. Yoshikawa, N. Sugiura, K. Kato, F. Kondo, T. Matsumoto, and H. Saisho, “Assessment of cancer cell differentiation in small hepatocellular carcinoma by computed tomography and magnetic resonance imaging,” J. Gastroenterol. Hepatol. 18(3), 273–279 (2003).
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R. K. Do, A. McErlean, C. S. Ang, R. P. DeMatteo, and G. K. Abou-Alfa, “CT and MRI of primary and metastatic fibrolamellar carcinoma: a case series of 37 patients,” Br. J. Radiol. 87(1040), 20140024 (2014).
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B. L. McVicker, G. M. Thiele, D. J. Tuma, and C. A. Casey, “Hepatocyte-mediated cytotoxicity and host defense mechanisms in the alcohol-injured liver,” Hepatol. Int. 8(S2), 432–438 (2014).
[Crossref]

Minami, T.

K. Ozaki, S. Kobayashi, O. Matsui, T. Minami, W. Koda, and T. Gabata, “Extrahepatic Arteries Originating from Hepatic Arteries: Analysis Using CT During Hepatic Arteriography and Visualization on Digital Subtraction Angiography,” Cardiovasc. Intervent. Radiol. 40(6), 822–830 (2017).
[Crossref]

Mladenovic, D.

T. Radosavljević, D. Mladenović, and D. Vucević, “The role of oxidative stress in alcoholic liver injury,” Med. Pregl. 62(11-12), 547–553 (2009).
[Crossref]

Mytilinaiou, M. G.

D. Villalta, M. G. Mytilinaiou, M. Elsner, C. Hentschel, J. Cuccato, V. Somma, P. Schierack, D. Roggenbuck, and D. P. Bogdanos, “Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases,” Clin. Chim. Acta 450, 1–5 (2015).
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V. Ntziachristos and D. Razansky, “Optical and opto-acoustic imaging,” Recent Results Cancer Res. 187, 133–150 (2013).
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Ozaki, K.

K. Ozaki, S. Kobayashi, O. Matsui, T. Minami, W. Koda, and T. Gabata, “Extrahepatic Arteries Originating from Hepatic Arteries: Analysis Using CT During Hepatic Arteriography and Visualization on Digital Subtraction Angiography,” Cardiovasc. Intervent. Radiol. 40(6), 822–830 (2017).
[Crossref]

Pan, C. X.

H. Y. Zhang, O. H. Aina, K. S. Lam, R. de Vere White, E. Christopher, H. Paul, P. N. Lara, X. Wang, J. A. Bassuk, and C. X. Pan, “Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach,” Urol. Oncol. 30(5), 635–645 (2012).
[Crossref]

Paul, H.

H. Y. Zhang, O. H. Aina, K. S. Lam, R. de Vere White, E. Christopher, H. Paul, P. N. Lara, X. Wang, J. A. Bassuk, and C. X. Pan, “Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach,” Urol. Oncol. 30(5), 635–645 (2012).
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L. Petitclerc, G. Sebastiani, G. Gilbert, G. Cloutier, and A. Tang, “Liver fibrosis: Review of current imaging and MRI quantification techniques,” J. Magn. Reson. Imaging. 45(5), 1276–1295 (2017).
[Crossref]

Polosukhin, V. V.

W. Han, R. Zaynagetdinov, F. E. Yull, V. V. Polosukhin, L. A. Gleaves, and H. Tanjore, “Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation,” Am. J. Respir. Cell Mol. Biol. 53(1), 50–59 (2015).
[Crossref]

Radosavljevic, T.

T. Radosavljević, D. Mladenović, and D. Vucević, “The role of oxidative stress in alcoholic liver injury,” Med. Pregl. 62(11-12), 547–553 (2009).
[Crossref]

Razansky, D.

V. Ntziachristos and D. Razansky, “Optical and opto-acoustic imaging,” Recent Results Cancer Res. 187, 133–150 (2013).
[Crossref]

Roggenbuck, D.

D. Villalta, M. G. Mytilinaiou, M. Elsner, C. Hentschel, J. Cuccato, V. Somma, P. Schierack, D. Roggenbuck, and D. P. Bogdanos, “Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases,” Clin. Chim. Acta 450, 1–5 (2015).
[Crossref]

Saha, B.

G. Szabo, B. Saha, and T. N. Bukong, “Alcohol and HCV: implications for liver cancer,” Adv. Exp. Med. Biol. 815, 197–216 (2015).
[Crossref]

Saisho, H.

S. Amano, M. Ebara, T. Yajima, H. Fukuda, M. Yoshikawa, N. Sugiura, K. Kato, F. Kondo, T. Matsumoto, and H. Saisho, “Assessment of cancer cell differentiation in small hepatocellular carcinoma by computed tomography and magnetic resonance imaging,” J. Gastroenterol. Hepatol. 18(3), 273–279 (2003).
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S. G. Sakka, “Assessing liver function,” Curr. Opin. Crit. Care. 13(2), 207–214 (2007).
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M. Matsumoto, I. Cyganek, P. C. Sanghani, W. K. Cho, S. Liangpunsakul, and D. W. Crabb, “Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration,” Alcohol.: Clin. Exp. Res. 35(1), 28–38 (2011).
[Crossref]

Schierack, P.

D. Villalta, M. G. Mytilinaiou, M. Elsner, C. Hentschel, J. Cuccato, V. Somma, P. Schierack, D. Roggenbuck, and D. P. Bogdanos, “Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases,” Clin. Chim. Acta 450, 1–5 (2015).
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Sebastiani, G.

L. Petitclerc, G. Sebastiani, G. Gilbert, G. Cloutier, and A. Tang, “Liver fibrosis: Review of current imaging and MRI quantification techniques,” J. Magn. Reson. Imaging. 45(5), 1276–1295 (2017).
[Crossref]

Solomon, H.

M. A. Khan, C. S. Combs, E. M. Brunt, V. J. Lowe, M. K. Wolverson, H. Solomon, B. T. Collins, and A. M. Di Bisceglie, “Positron emission tomography scanning in the evaluation of hepatocellular carcinoma,” J. Hepatol. 32(5), 792–797 (2000).
[Crossref]

Somma, V.

D. Villalta, M. G. Mytilinaiou, M. Elsner, C. Hentschel, J. Cuccato, V. Somma, P. Schierack, D. Roggenbuck, and D. P. Bogdanos, “Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases,” Clin. Chim. Acta 450, 1–5 (2015).
[Crossref]

Song, X.J.

D. Zhang, X.J. Song, S.Y. Li, S.Y. Wang, B.J. Chen, X.D. Bai, and L.M. Tang, “Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods,” Sci. Rep. 6(1), 30119 (2016).
[Crossref]

Su, X. H.

D. Zhang, Z. Guo, P. Zhang, Y. Li, X. H. Su, L. Y. You, M. Gao, C. Liu, H. Wu, and X. Z. Zhang, “Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with (99 m)Tc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice,” Sci. Rep. 6(1), 25377 (2016).
[Crossref]

Sugiura, N.

S. Amano, M. Ebara, T. Yajima, H. Fukuda, M. Yoshikawa, N. Sugiura, K. Kato, F. Kondo, T. Matsumoto, and H. Saisho, “Assessment of cancer cell differentiation in small hepatocellular carcinoma by computed tomography and magnetic resonance imaging,” J. Gastroenterol. Hepatol. 18(3), 273–279 (2003).
[Crossref]

Szabo, G.

G. Szabo, B. Saha, and T. N. Bukong, “Alcohol and HCV: implications for liver cancer,” Adv. Exp. Med. Biol. 815, 197–216 (2015).
[Crossref]

Tang, A.

L. Petitclerc, G. Sebastiani, G. Gilbert, G. Cloutier, and A. Tang, “Liver fibrosis: Review of current imaging and MRI quantification techniques,” J. Magn. Reson. Imaging. 45(5), 1276–1295 (2017).
[Crossref]

Tang, L.M.

D. Zhang, X.J. Song, S.Y. Li, S.Y. Wang, B.J. Chen, X.D. Bai, and L.M. Tang, “Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods,” Sci. Rep. 6(1), 30119 (2016).
[Crossref]

Tanjore, H.

W. Han, R. Zaynagetdinov, F. E. Yull, V. V. Polosukhin, L. A. Gleaves, and H. Tanjore, “Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation,” Am. J. Respir. Cell Mol. Biol. 53(1), 50–59 (2015).
[Crossref]

Tao, L. Q.

W. Jing, J. Li, L. Q. Tao, J. Zhe, L. B. Liang, and Z. Ke, “Prediction of asialoglycoprotein receptors by correlated liver function parameters before hepatectomy,” J. Pak. Med. Assoc. 66(Suppl 3), S56–S58 (2016).

Thiele, G. M.

B. L. McVicker, G. M. Thiele, D. J. Tuma, and C. A. Casey, “Hepatocyte-mediated cytotoxicity and host defense mechanisms in the alcohol-injured liver,” Hepatol. Int. 8(S2), 432–438 (2014).
[Crossref]

Tuma, D. J.

B. L. McVicker, G. M. Thiele, D. J. Tuma, and C. A. Casey, “Hepatocyte-mediated cytotoxicity and host defense mechanisms in the alcohol-injured liver,” Hepatol. Int. 8(S2), 432–438 (2014).
[Crossref]

Venkatesh, S. K.

T. Hennedige and S. K. Venkatesh, “Imaging of hepatocellular carcinoma: diagnosis, staging and treatment monitoring,” Cancer Imaging. 12(3), 530–547 (2012).
[Crossref]

Villalta, D.

D. Villalta, M. G. Mytilinaiou, M. Elsner, C. Hentschel, J. Cuccato, V. Somma, P. Schierack, D. Roggenbuck, and D. P. Bogdanos, “Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases,” Clin. Chim. Acta 450, 1–5 (2015).
[Crossref]

Vucevic, D.

T. Radosavljević, D. Mladenović, and D. Vucević, “The role of oxidative stress in alcoholic liver injury,” Med. Pregl. 62(11-12), 547–553 (2009).
[Crossref]

Wang, H.

A. Bertola, S. Mathews, S. H. Ki, H. Wang, and B. Gao, “Mouse model of chronic and binge ethanol feeding (the NIAAA model),” Nat. Protoc. 8(3), 627–637 (2013).
[Crossref]

Wang, S.Y.

D. Zhang, X.J. Song, S.Y. Li, S.Y. Wang, B.J. Chen, X.D. Bai, and L.M. Tang, “Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods,” Sci. Rep. 6(1), 30119 (2016).
[Crossref]

Wang, X.

H. Y. Zhang, O. H. Aina, K. S. Lam, R. de Vere White, E. Christopher, H. Paul, P. N. Lara, X. Wang, J. A. Bassuk, and C. X. Pan, “Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach,” Urol. Oncol. 30(5), 635–645 (2012).
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S. R. Wilson and P. N. Burns, “An algorithm for the diagnosis of focal liver masses using microbubble contrast-enhanced pulse-inversion sonography,” AJR, Am. J. Roentgenol. 186(5), 1401–1412 (2006).
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M. A. Khan, C. S. Combs, E. M. Brunt, V. J. Lowe, M. K. Wolverson, H. Solomon, B. T. Collins, and A. M. Di Bisceglie, “Positron emission tomography scanning in the evaluation of hepatocellular carcinoma,” J. Hepatol. 32(5), 792–797 (2000).
[Crossref]

Wu, H.

D. Zhang, Z. Guo, P. Zhang, Y. Li, X. H. Su, L. Y. You, M. Gao, C. Liu, H. Wu, and X. Z. Zhang, “Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with (99 m)Tc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice,” Sci. Rep. 6(1), 25377 (2016).
[Crossref]

Yajima, T.

S. Amano, M. Ebara, T. Yajima, H. Fukuda, M. Yoshikawa, N. Sugiura, K. Kato, F. Kondo, T. Matsumoto, and H. Saisho, “Assessment of cancer cell differentiation in small hepatocellular carcinoma by computed tomography and magnetic resonance imaging,” J. Gastroenterol. Hepatol. 18(3), 273–279 (2003).
[Crossref]

Yan, L.

Z. Ke, J. Li, J. Zhe, L. B. Liang, L. Yan, and M. Yi, “Flow cytometric analysis of asialoglycoprotein receptor expression predicts hepatic functional reserve after hepatectomy,” J. Coll. Physicians. Surg. Pak. 24(11), 820–824 (2014).

Yang, D.

J. Hu, J. Liu, D. Yang, M. Lu, and J. Yin, “Physiological roles of asialoglycoprotein receptors (ASGPRs) variants and recent advances in hepatic-targeted delivery of therapeutic molecules via ASGPRs,” Protein Pept. Lett. 21(10), 1025–1030 (2014).
[Crossref]

Yi, M.

Z. Ke, J. Li, J. Zhe, L. B. Liang, L. Yan, and M. Yi, “Flow cytometric analysis of asialoglycoprotein receptor expression predicts hepatic functional reserve after hepatectomy,” J. Coll. Physicians. Surg. Pak. 24(11), 820–824 (2014).

Yin, J.

J. Hu, J. Liu, D. Yang, M. Lu, and J. Yin, “Physiological roles of asialoglycoprotein receptors (ASGPRs) variants and recent advances in hepatic-targeted delivery of therapeutic molecules via ASGPRs,” Protein Pept. Lett. 21(10), 1025–1030 (2014).
[Crossref]

Yoshikawa, M.

S. Amano, M. Ebara, T. Yajima, H. Fukuda, M. Yoshikawa, N. Sugiura, K. Kato, F. Kondo, T. Matsumoto, and H. Saisho, “Assessment of cancer cell differentiation in small hepatocellular carcinoma by computed tomography and magnetic resonance imaging,” J. Gastroenterol. Hepatol. 18(3), 273–279 (2003).
[Crossref]

You, L. Y.

D. Zhang, Z. Guo, P. Zhang, Y. Li, X. H. Su, L. Y. You, M. Gao, C. Liu, H. Wu, and X. Z. Zhang, “Simplified quantification method for in vivo SPECT/CT imaging of asialoglycoprotein receptor with (99 m)Tc-p(VLA-co-VNI) to assess and stage hepatic fibrosis in mice,” Sci. Rep. 6(1), 25377 (2016).
[Crossref]

Yu, J.

H. Y. Zhai, P. Liang, J. Yu, F. Cao, M. Kuang, F. Y. Liu, F. Y. Liu, and X. Y. Zhu, “Comparison of Sonazoid and Sonovue in the Diagnosis of Focal Liver Lesions: A Preliminary Study,” J. Ultrasound. Med. 38(9), 2417–2425 (2019).
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Figures (4)

Fig. 1.
Fig. 1. Targeted visualization of ASGPR by IVFI with Cy5.5-GP. On IVFI, the red area in the middle of the mouse abdomen indicates Cy5.5-GP binding with hepatocyte ASGPR. Inj. inst.: Immediately after Cy5.5-GP injection. A: Cy5.5-GP IVFI, CG I (n = 10). After Cy5.5-GP injection, slow aggregation of fluorescence in the liver was observed; from 10-30 min, the FI gradually increased; from 30-60 min, the FI reached the highest level, and the FA was the largest; from 60-90 min, the FI and FA were stable; at 120 min, the FI was slightly decreased, and the FA was decreased; at 150 min, the FI was significantly attenuated. B: Cy5.5-GP IVFI, CG II (n = 10). There was no fluorescence signal aggregation in the liver at any point. C: Cy5.5-GP IVFI, cALIG I (n = 10). From 30-150 min, the fluorescence distribution characteristics in the liver were similar to that in CG I; however, the FA was significantly lower than that in CG I. D: Cy5.5-GP IVFI, CG II (n = 10). The results are consistent with those observed in CG II. E: IVFI of the liver lobe at 60 min after Cy5.5-GP injection; n = 2 animals in each group. The FI was highest in CG I, followed by cALIG I, CG II and cALIG II. F: Cy5.5 IVFI, CG Ш (n = 5). G: Cy5.5 IVFI, cALIG Ш (n = 5). There was no fluorescence signal aggregation in the liver at any time point in the latter two groups. The color index was intensity scale.
Fig. 2.
Fig. 2. Quantification of Cy5.5-GP data between CG I and cALIG I. A: Liver Cy5.5-GP FI over time. B: Liver Cy5.5-GP FA over time. (*P < 0.01 vs CG, LSD two-group comparison test; n = 10 animals in each group). inj.: Immediately after Cy5.5-GP injection. The data are shown as the mean ± SD.
Fig. 3.
Fig. 3. ASGPR expression in the liver tissue of healthy mice (CG I) and cALI mice (cALIG I). A: ASGPR expression in hepatocytes determined by Western blot analysis. ASGPR and tubulin expression in CG (lane 1) and cALIG (lane 2); n = 10 animals in each group. B: Densitometric analysis of the Western blot results of ASGPR expression based on tubulin expression; n = 10 animals in each group. C: Densitometric analysis of ASGPR expression by ELISA; n = 10 animals in each group. (*P < 0.05 vs CG; LSD two-group comparison test). The data are shown as the mean ± SD.
Fig. 4.
Fig. 4. Comparison of liver histology and serum marker levels. A and B: H&E staining of liver tissue (10×); scale bar: 100 µm, A was CG I, B was cALIG I; n = 10 animals in each group. The black arrow indicates steatotic hepatocytes, the yellow arrow indicates necrotic hepatocytes, and the green arrow indicates swollen and distended hepatocytes. C: Comparison of the ALT level between CG I and cALIG I; n = 10 animals in each group. D: Comparison of the AST level between the two groups; n = 10 animals in each group. E: Comparison of the GGT level between the two groups; n = 10 animals in each group. F: Comparison of the TBA level between the two groups; n = 10 animals in each group. (*P < 0.05 vs CG; LSD two-group comparison test). The data are shown as the mean ± SD.