Abstract

With an optical fiber probe, we acquired spectra from swine tissue between 500 and 1600 nm by combining a silicon and an InGaAs spectrometer. The concentrations of the biological chromophores were estimated by fitting a mathematical model derived from diffusion theory. The advantage of our technique relative to those presented in previous studies is that we extended the commonly-used wavelength ranges of 500 and 1000 nm to include the range of 1000 to 1600 nm, where additional water and lipid absorption features exist. Hence, a more accurate estimation of these two chromophores is expected when spectra are fitted between 500 and 1600 nm than between 500 and 1000 nm. When extending the UV-VIS wavelength range, the estimated total amount of chromophores approached 100% of the total as present in the probed volume. The confidence levels of the water and lipid related parameters increases by a factor of four.

© 2010 OSA

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2010 (1)

R. Nachabé, B. H. W. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. C. M. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1,600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
[CrossRef] [PubMed]

2009 (2)

J. Q. Brown, L. G. Wilke, J. Geradts, S. A. Kennedy, G. M. Palmer, and N. Ramanujam, “Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo,” Cancer Res. 69(7), 2919–2926 (2009).
[CrossRef] [PubMed]

G. Zonios and A. Dimou, “Light scattering spectroscopy of human skin in vivo,” Opt. Express 17(3), 1256–1267 (2009).
[CrossRef] [PubMed]

2008 (3)

G. Zonios, I. Bassukas, and A. Dimou, “Comparative evaluation of two simple diffuse reflectance models for biological tissue applications,” Appl. Opt. 47(27), 4965–4973 (2008).
[CrossRef] [PubMed]

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt. 13(2), 024012 (2008).
[CrossRef] [PubMed]

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, “Confidence intervals on fit parameters derived from optical reflectance spectroscopy measurements,” J. Biomed. Opt. 13(5), 054044 (2008).
[CrossRef] [PubMed]

2007 (1)

2006 (2)

G. Zonios and A. Dimou, “Modeling diffuse reflectance from semi-infinite turbid media: application to the study of skin optical properties,” Opt. Express 14(19), 8661–8674 (2006).
[CrossRef] [PubMed]

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

2005 (5)

A. Amelink, A. van der Ploeg van den Heuvel, W. J. de Wolf, D. J. Robinson, and H. J. C. M. Sterenborg, “Monitoring PDT by means of superficial reflectance spectroscopy,” J. Photochem. Photobiol. B 79(3), 243–251 (2005).
[CrossRef] [PubMed]

R. L. P. van Veen, A. Amelink, M. Menke-Pluymers, C. van der Pol, and H. J. C. M. Sterenborg, “Optical biopsy of breast tissue using differential path-length spectroscopy,” Phys. Med. Biol. 50(11), 2573–2581 (2005).
[CrossRef] [PubMed]

R. L. P. van Veen, H. J. C. M. Sterenborg, A. Pifferi, A. Torricelli, E. Chikoidze, and R. Cubeddu, “Determination of visible near-IR absorption coefficients of mammalian fat using time- and spatially resolved diffuse reflectance and transmission spectroscopy,” J. Biomed. Opt. 10(5), 054004 (2005).
[CrossRef] [PubMed]

P. R. Bargo, S. A. Prahl, T. T. Goodell, R. A. Sleven, G. Koval, G. Blair, and S. L. Jacques, “In vivo determination of optical properties of normal and tumor tissue with white light reflectance and an empirical light transport model during endoscopy,” J. Biomed. Opt. 10(3), 034018 (2005).
[CrossRef] [PubMed]

M. P. Bard, A. Amelink, V. N. Hegt, W. J. Graveland, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts, “Measurement of hypoxia-related parameters in bronchial mucosa by use of optical spectroscopy,” Am. J. Respir. Crit. Care Med. 171(10), 1178–1184 (2005).
[CrossRef] [PubMed]

2004 (2)

A. Amelink, H. J. C. M. Sterenborg, M. P. L. Bard, and S. A. Burgers, “In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy,” Opt. Lett. 29(10), 1087–1089 (2004).
[CrossRef] [PubMed]

A. Pifferi, A. Torricelli, P. Taroni, A. Bassi, E. Chikoidze, E. Giambattistelli, and R. Cubeddu, “Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies,” J. Biomed. Opt. 9(3), 474–480 (2004).
[CrossRef] [PubMed]

2003 (1)

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, and O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

2002 (1)

2000 (1)

I. J. Bigio, S. G. Bown, G. Briggs, C. Kelley, S. Lakhani, D. Pickard, P. M. Ripley, I. G. Rose, and C. Saunders, “Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results,” J. Biomed. Opt. 5(2), 221–228 (2000).
[CrossRef] [PubMed]

1999 (2)

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, “Optical properties of circulating human blood in the wavelength range of 400-2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

G. Zonios, L. T. Perelman, V. M. Backman, R. Manoharan, M. Fitzmaurice, J. Van Dam, and M. S. Feld, “Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo,” Appl. Opt. 38(31), 6628–6637 (1999).
[CrossRef] [PubMed]

1997 (1)

W. Verkruysse, G. W. Lucassen, J. F. de Boer, D. J. Smithies, J. S. Nelson, and M. J. C. van Gemert, “Modelling light distributions of homogeneous versus discrete absorbers in light irradiated turbid media,” Phys. Med. Biol. 42(1), 51–65 (1997).
[CrossRef] [PubMed]

1996 (1)

C. M. Gardner, S. L. Jacques, and A. J. Welch, “Light transport in tissue: Accurate expressions for one-dimensional fluence rate and escape function based upon monte carlo simulation,” Lasers Surg. Med. 18(2), 129–138 (1996).
[CrossRef] [PubMed]

1995 (2)

S. Fantini, M. A. Francechini-Fantini, J. S. Maier, S. A. Walker, B. Barbieri, and E. Gratton, “Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry,” Opt. Eng. 34(1), 32–42 (1995).
[CrossRef]

I. S. Saidi, S. L. Jacques, and F. K. Tittel, “Mie and Rayleigh modeling of visible-light scattering in neonatal skin,” Appl. Opt. 34(31), 7410–7418 (1995).
[CrossRef]

1993 (1)

1992 (1)

T. J. Farrell, M. S. Patterson, and B. Wilson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19(4), 879–888 (1992).
[CrossRef] [PubMed]

1991 (1)

1973 (1)

A’Amar, O.

Aerts, J. G. J. V.

M. P. Bard, A. Amelink, V. N. Hegt, W. J. Graveland, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts, “Measurement of hypoxia-related parameters in bronchial mucosa by use of optical spectroscopy,” Am. J. Respir. Crit. Care Med. 171(10), 1178–1184 (2005).
[CrossRef] [PubMed]

Amelink, A.

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, “Confidence intervals on fit parameters derived from optical reflectance spectroscopy measurements,” J. Biomed. Opt. 13(5), 054044 (2008).
[CrossRef] [PubMed]

A. Amelink, A. van der Ploeg van den Heuvel, W. J. de Wolf, D. J. Robinson, and H. J. C. M. Sterenborg, “Monitoring PDT by means of superficial reflectance spectroscopy,” J. Photochem. Photobiol. B 79(3), 243–251 (2005).
[CrossRef] [PubMed]

M. P. Bard, A. Amelink, V. N. Hegt, W. J. Graveland, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts, “Measurement of hypoxia-related parameters in bronchial mucosa by use of optical spectroscopy,” Am. J. Respir. Crit. Care Med. 171(10), 1178–1184 (2005).
[CrossRef] [PubMed]

R. L. P. van Veen, A. Amelink, M. Menke-Pluymers, C. van der Pol, and H. J. C. M. Sterenborg, “Optical biopsy of breast tissue using differential path-length spectroscopy,” Phys. Med. Biol. 50(11), 2573–2581 (2005).
[CrossRef] [PubMed]

A. Amelink, H. J. C. M. Sterenborg, M. P. L. Bard, and S. A. Burgers, “In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy,” Opt. Lett. 29(10), 1087–1089 (2004).
[CrossRef] [PubMed]

Andersson-Engels, S.

Backman, V. M.

Barbieri, B.

S. Fantini, M. A. Francechini-Fantini, J. S. Maier, S. A. Walker, B. Barbieri, and E. Gratton, “Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry,” Opt. Eng. 34(1), 32–42 (1995).
[CrossRef]

Bard, M. P.

M. P. Bard, A. Amelink, V. N. Hegt, W. J. Graveland, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts, “Measurement of hypoxia-related parameters in bronchial mucosa by use of optical spectroscopy,” Am. J. Respir. Crit. Care Med. 171(10), 1178–1184 (2005).
[CrossRef] [PubMed]

Bard, M. P. L.

Bargo, P. R.

P. R. Bargo, S. A. Prahl, T. T. Goodell, R. A. Sleven, G. Koval, G. Blair, and S. L. Jacques, “In vivo determination of optical properties of normal and tumor tissue with white light reflectance and an empirical light transport model during endoscopy,” J. Biomed. Opt. 10(3), 034018 (2005).
[CrossRef] [PubMed]

Bassi, A.

A. Pifferi, A. Torricelli, P. Taroni, A. Bassi, E. Chikoidze, E. Giambattistelli, and R. Cubeddu, “Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies,” J. Biomed. Opt. 9(3), 474–480 (2004).
[CrossRef] [PubMed]

Bassukas, I.

Bechtel, K. L.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt. 13(2), 024012 (2008).
[CrossRef] [PubMed]

Berg, R.

Bigio, I. J.

R. Reif, O. A’Amar, and I. J. Bigio, “Analytical model of light reflectance for extraction of the optical properties in small volumes of turbid media,” Appl. Opt. 46(29), 7317–7328 (2007).
[CrossRef] [PubMed]

I. J. Bigio, S. G. Bown, G. Briggs, C. Kelley, S. Lakhani, D. Pickard, P. M. Ripley, I. G. Rose, and C. Saunders, “Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results,” J. Biomed. Opt. 5(2), 221–228 (2000).
[CrossRef] [PubMed]

Blair, G.

P. R. Bargo, S. A. Prahl, T. T. Goodell, R. A. Sleven, G. Koval, G. Blair, and S. L. Jacques, “In vivo determination of optical properties of normal and tumor tissue with white light reflectance and an empirical light transport model during endoscopy,” J. Biomed. Opt. 10(3), 034018 (2005).
[CrossRef] [PubMed]

Bown, S. G.

I. J. Bigio, S. G. Bown, G. Briggs, C. Kelley, S. Lakhani, D. Pickard, P. M. Ripley, I. G. Rose, and C. Saunders, “Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results,” J. Biomed. Opt. 5(2), 221–228 (2000).
[CrossRef] [PubMed]

Briggs, G.

I. J. Bigio, S. G. Bown, G. Briggs, C. Kelley, S. Lakhani, D. Pickard, P. M. Ripley, I. G. Rose, and C. Saunders, “Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results,” J. Biomed. Opt. 5(2), 221–228 (2000).
[CrossRef] [PubMed]

Brown, J. Q.

J. Q. Brown, L. G. Wilke, J. Geradts, S. A. Kennedy, G. M. Palmer, and N. Ramanujam, “Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo,” Cancer Res. 69(7), 2919–2926 (2009).
[CrossRef] [PubMed]

Burgers, S. A.

Butler, J.

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

Cerussi, A. E.

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, and O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Chikoidze, E.

R. L. P. van Veen, H. J. C. M. Sterenborg, A. Pifferi, A. Torricelli, E. Chikoidze, and R. Cubeddu, “Determination of visible near-IR absorption coefficients of mammalian fat using time- and spatially resolved diffuse reflectance and transmission spectroscopy,” J. Biomed. Opt. 10(5), 054004 (2005).
[CrossRef] [PubMed]

A. Pifferi, A. Torricelli, P. Taroni, A. Bassi, E. Chikoidze, E. Giambattistelli, and R. Cubeddu, “Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies,” J. Biomed. Opt. 9(3), 474–480 (2004).
[CrossRef] [PubMed]

Chiou, G.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, and O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Chu, Y.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, and O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Cubeddu, R.

R. L. P. van Veen, H. J. C. M. Sterenborg, A. Pifferi, A. Torricelli, E. Chikoidze, and R. Cubeddu, “Determination of visible near-IR absorption coefficients of mammalian fat using time- and spatially resolved diffuse reflectance and transmission spectroscopy,” J. Biomed. Opt. 10(5), 054004 (2005).
[CrossRef] [PubMed]

A. Pifferi, A. Torricelli, P. Taroni, A. Bassi, E. Chikoidze, E. Giambattistelli, and R. Cubeddu, “Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies,” J. Biomed. Opt. 9(3), 474–480 (2004).
[CrossRef] [PubMed]

Dasari, R. R.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt. 13(2), 024012 (2008).
[CrossRef] [PubMed]

de Boer, J. F.

W. Verkruysse, G. W. Lucassen, J. F. de Boer, D. J. Smithies, J. S. Nelson, and M. J. C. van Gemert, “Modelling light distributions of homogeneous versus discrete absorbers in light irradiated turbid media,” Phys. Med. Biol. 42(1), 51–65 (1997).
[CrossRef] [PubMed]

de Wolf, W. J.

A. Amelink, A. van der Ploeg van den Heuvel, W. J. de Wolf, D. J. Robinson, and H. J. C. M. Sterenborg, “Monitoring PDT by means of superficial reflectance spectroscopy,” J. Photochem. Photobiol. B 79(3), 243–251 (2005).
[CrossRef] [PubMed]

Deng, C.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, and O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Desjardins, A. E.

R. Nachabé, B. H. W. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. C. M. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1,600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
[CrossRef] [PubMed]

Dimou, A.

Dörschel, K.

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, “Optical properties of circulating human blood in the wavelength range of 400-2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

Durkin, A.

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

Durkin, A. J.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, and O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Fantini, S.

S. Fantini, M. A. Francechini-Fantini, J. S. Maier, S. A. Walker, B. Barbieri, and E. Gratton, “Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry,” Opt. Eng. 34(1), 32–42 (1995).
[CrossRef]

Farrell, T. J.

T. J. Farrell, M. S. Patterson, and B. Wilson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19(4), 879–888 (1992).
[CrossRef] [PubMed]

Feld, M. S.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt. 13(2), 024012 (2008).
[CrossRef] [PubMed]

G. Zonios, L. T. Perelman, V. M. Backman, R. Manoharan, M. Fitzmaurice, J. Van Dam, and M. S. Feld, “Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo,” Appl. Opt. 38(31), 6628–6637 (1999).
[CrossRef] [PubMed]

Fitzmaurice, M.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt. 13(2), 024012 (2008).
[CrossRef] [PubMed]

G. Zonios, L. T. Perelman, V. M. Backman, R. Manoharan, M. Fitzmaurice, J. Van Dam, and M. S. Feld, “Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo,” Appl. Opt. 38(31), 6628–6637 (1999).
[CrossRef] [PubMed]

Francechini-Fantini, M. A.

S. Fantini, M. A. Francechini-Fantini, J. S. Maier, S. A. Walker, B. Barbieri, and E. Gratton, “Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry,” Opt. Eng. 34(1), 32–42 (1995).
[CrossRef]

Friebel, M.

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, “Optical properties of circulating human blood in the wavelength range of 400-2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

Gardner, C. M.

C. M. Gardner, S. L. Jacques, and A. J. Welch, “Light transport in tissue: Accurate expressions for one-dimensional fluence rate and escape function based upon monte carlo simulation,” Lasers Surg. Med. 18(2), 129–138 (1996).
[CrossRef] [PubMed]

Geradts, J.

J. Q. Brown, L. G. Wilke, J. Geradts, S. A. Kennedy, G. M. Palmer, and N. Ramanujam, “Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo,” Cancer Res. 69(7), 2919–2926 (2009).
[CrossRef] [PubMed]

Giambattistelli, E.

A. Pifferi, A. Torricelli, P. Taroni, A. Bassi, E. Chikoidze, E. Giambattistelli, and R. Cubeddu, “Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies,” J. Biomed. Opt. 9(3), 474–480 (2004).
[CrossRef] [PubMed]

Goodell, T. T.

P. R. Bargo, S. A. Prahl, T. T. Goodell, R. A. Sleven, G. Koval, G. Blair, and S. L. Jacques, “In vivo determination of optical properties of normal and tumor tissue with white light reflectance and an empirical light transport model during endoscopy,” J. Biomed. Opt. 10(3), 034018 (2005).
[CrossRef] [PubMed]

Gratton, E.

S. Fantini, M. A. Francechini-Fantini, J. S. Maier, S. A. Walker, B. Barbieri, and E. Gratton, “Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry,” Opt. Eng. 34(1), 32–42 (1995).
[CrossRef]

Graveland, W. J.

M. P. Bard, A. Amelink, V. N. Hegt, W. J. Graveland, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts, “Measurement of hypoxia-related parameters in bronchial mucosa by use of optical spectroscopy,” Am. J. Respir. Crit. Care Med. 171(10), 1178–1184 (2005).
[CrossRef] [PubMed]

Gulsen, G.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, and O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Hahn, A.

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, “Optical properties of circulating human blood in the wavelength range of 400-2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

Haka, A. S.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt. 13(2), 024012 (2008).
[CrossRef] [PubMed]

Hale, G. M.

Hegt, V. N.

M. P. Bard, A. Amelink, V. N. Hegt, W. J. Graveland, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts, “Measurement of hypoxia-related parameters in bronchial mucosa by use of optical spectroscopy,” Am. J. Respir. Crit. Care Med. 171(10), 1178–1184 (2005).
[CrossRef] [PubMed]

Hendriks, B. H. W.

R. Nachabé, B. H. W. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. C. M. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1,600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
[CrossRef] [PubMed]

Hoogsteden, H. C.

M. P. Bard, A. Amelink, V. N. Hegt, W. J. Graveland, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts, “Measurement of hypoxia-related parameters in bronchial mucosa by use of optical spectroscopy,” Am. J. Respir. Crit. Care Med. 171(10), 1178–1184 (2005).
[CrossRef] [PubMed]

Hsiang, D.

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

Jacques, S. L.

P. R. Bargo, S. A. Prahl, T. T. Goodell, R. A. Sleven, G. Koval, G. Blair, and S. L. Jacques, “In vivo determination of optical properties of normal and tumor tissue with white light reflectance and an empirical light transport model during endoscopy,” J. Biomed. Opt. 10(3), 034018 (2005).
[CrossRef] [PubMed]

C. M. Gardner, S. L. Jacques, and A. J. Welch, “Light transport in tissue: Accurate expressions for one-dimensional fluence rate and escape function based upon monte carlo simulation,” Lasers Surg. Med. 18(2), 129–138 (1996).
[CrossRef] [PubMed]

I. S. Saidi, S. L. Jacques, and F. K. Tittel, “Mie and Rayleigh modeling of visible-light scattering in neonatal skin,” Appl. Opt. 34(31), 7410–7418 (1995).
[CrossRef]

Kelley, C.

I. J. Bigio, S. G. Bown, G. Briggs, C. Kelley, S. Lakhani, D. Pickard, P. M. Ripley, I. G. Rose, and C. Saunders, “Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results,” J. Biomed. Opt. 5(2), 221–228 (2000).
[CrossRef] [PubMed]

Kennedy, S. A.

J. Q. Brown, L. G. Wilke, J. Geradts, S. A. Kennedy, G. M. Palmer, and N. Ramanujam, “Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo,” Cancer Res. 69(7), 2919–2926 (2009).
[CrossRef] [PubMed]

Koval, G.

P. R. Bargo, S. A. Prahl, T. T. Goodell, R. A. Sleven, G. Koval, G. Blair, and S. L. Jacques, “In vivo determination of optical properties of normal and tumor tissue with white light reflectance and an empirical light transport model during endoscopy,” J. Biomed. Opt. 10(3), 034018 (2005).
[CrossRef] [PubMed]

Lakhani, S.

I. J. Bigio, S. G. Bown, G. Briggs, C. Kelley, S. Lakhani, D. Pickard, P. M. Ripley, I. G. Rose, and C. Saunders, “Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results,” J. Biomed. Opt. 5(2), 221–228 (2000).
[CrossRef] [PubMed]

Lucassen, G. W.

W. Verkruysse, G. W. Lucassen, J. F. de Boer, D. J. Smithies, J. S. Nelson, and M. J. C. van Gemert, “Modelling light distributions of homogeneous versus discrete absorbers in light irradiated turbid media,” Phys. Med. Biol. 42(1), 51–65 (1997).
[CrossRef] [PubMed]

Maier, J. S.

S. Fantini, M. A. Francechini-Fantini, J. S. Maier, S. A. Walker, B. Barbieri, and E. Gratton, “Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry,” Opt. Eng. 34(1), 32–42 (1995).
[CrossRef]

Manoharan, R.

Menke-Pluymers, M.

R. L. P. van Veen, A. Amelink, M. Menke-Pluymers, C. van der Pol, and H. J. C. M. Sterenborg, “Optical biopsy of breast tissue using differential path-length spectroscopy,” Phys. Med. Biol. 50(11), 2573–2581 (2005).
[CrossRef] [PubMed]

Merritt, S.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, and O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Moes, C. J. M.

Müller, G.

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, “Optical properties of circulating human blood in the wavelength range of 400-2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

Nachabé, R.

R. Nachabé, B. H. W. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. C. M. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1,600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
[CrossRef] [PubMed]

Nalcioglu, O.

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, and O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Nazemi, J.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt. 13(2), 024012 (2008).
[CrossRef] [PubMed]

Nelson, J. S.

W. Verkruysse, G. W. Lucassen, J. F. de Boer, D. J. Smithies, J. S. Nelson, and M. J. C. van Gemert, “Modelling light distributions of homogeneous versus discrete absorbers in light irradiated turbid media,” Phys. Med. Biol. 42(1), 51–65 (1997).
[CrossRef] [PubMed]

Palmer, G. M.

J. Q. Brown, L. G. Wilke, J. Geradts, S. A. Kennedy, G. M. Palmer, and N. Ramanujam, “Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo,” Cancer Res. 69(7), 2919–2926 (2009).
[CrossRef] [PubMed]

Patterson, M. S.

T. J. Farrell, M. S. Patterson, and B. Wilson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19(4), 879–888 (1992).
[CrossRef] [PubMed]

Perelman, L. T.

Persson, A.

Pickard, D.

I. J. Bigio, S. G. Bown, G. Briggs, C. Kelley, S. Lakhani, D. Pickard, P. M. Ripley, I. G. Rose, and C. Saunders, “Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results,” J. Biomed. Opt. 5(2), 221–228 (2000).
[CrossRef] [PubMed]

Pifferi, A.

R. L. P. van Veen, H. J. C. M. Sterenborg, A. Pifferi, A. Torricelli, E. Chikoidze, and R. Cubeddu, “Determination of visible near-IR absorption coefficients of mammalian fat using time- and spatially resolved diffuse reflectance and transmission spectroscopy,” J. Biomed. Opt. 10(5), 054004 (2005).
[CrossRef] [PubMed]

A. Pifferi, A. Torricelli, P. Taroni, A. Bassi, E. Chikoidze, E. Giambattistelli, and R. Cubeddu, “Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies,” J. Biomed. Opt. 9(3), 474–480 (2004).
[CrossRef] [PubMed]

Prahl, S. A.

P. R. Bargo, S. A. Prahl, T. T. Goodell, R. A. Sleven, G. Koval, G. Blair, and S. L. Jacques, “In vivo determination of optical properties of normal and tumor tissue with white light reflectance and an empirical light transport model during endoscopy,” J. Biomed. Opt. 10(3), 034018 (2005).
[CrossRef] [PubMed]

H. J. van Staveren, C. J. M. Moes, J. van Marie, S. A. Prahl, and M. J. C. van Gemert, “Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm,” Appl. Opt. 30(31), 4507–4514 (1991).
[CrossRef] [PubMed]

Querry, M. R.

Ramanujam, N.

J. Q. Brown, L. G. Wilke, J. Geradts, S. A. Kennedy, G. M. Palmer, and N. Ramanujam, “Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo,” Cancer Res. 69(7), 2919–2926 (2009).
[CrossRef] [PubMed]

Reif, R.

Ripley, P. M.

I. J. Bigio, S. G. Bown, G. Briggs, C. Kelley, S. Lakhani, D. Pickard, P. M. Ripley, I. G. Rose, and C. Saunders, “Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results,” J. Biomed. Opt. 5(2), 221–228 (2000).
[CrossRef] [PubMed]

Robinson, D. J.

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, “Confidence intervals on fit parameters derived from optical reflectance spectroscopy measurements,” J. Biomed. Opt. 13(5), 054044 (2008).
[CrossRef] [PubMed]

A. Amelink, A. van der Ploeg van den Heuvel, W. J. de Wolf, D. J. Robinson, and H. J. C. M. Sterenborg, “Monitoring PDT by means of superficial reflectance spectroscopy,” J. Photochem. Photobiol. B 79(3), 243–251 (2005).
[CrossRef] [PubMed]

Roggan, A.

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, “Optical properties of circulating human blood in the wavelength range of 400-2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

Rose, I. G.

I. J. Bigio, S. G. Bown, G. Briggs, C. Kelley, S. Lakhani, D. Pickard, P. M. Ripley, I. G. Rose, and C. Saunders, “Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results,” J. Biomed. Opt. 5(2), 221–228 (2000).
[CrossRef] [PubMed]

Saidi, I. S.

Saunders, C.

I. J. Bigio, S. G. Bown, G. Briggs, C. Kelley, S. Lakhani, D. Pickard, P. M. Ripley, I. G. Rose, and C. Saunders, “Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results,” J. Biomed. Opt. 5(2), 221–228 (2000).
[CrossRef] [PubMed]

Shah, N.

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

Shenk, R.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt. 13(2), 024012 (2008).
[CrossRef] [PubMed]

Sleven, R. A.

P. R. Bargo, S. A. Prahl, T. T. Goodell, R. A. Sleven, G. Koval, G. Blair, and S. L. Jacques, “In vivo determination of optical properties of normal and tumor tissue with white light reflectance and an empirical light transport model during endoscopy,” J. Biomed. Opt. 10(3), 034018 (2005).
[CrossRef] [PubMed]

Smithies, D. J.

W. Verkruysse, G. W. Lucassen, J. F. de Boer, D. J. Smithies, J. S. Nelson, and M. J. C. van Gemert, “Modelling light distributions of homogeneous versus discrete absorbers in light irradiated turbid media,” Phys. Med. Biol. 42(1), 51–65 (1997).
[CrossRef] [PubMed]

Sterenborg, H. J. C. M.

R. Nachabé, B. H. W. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. C. M. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1,600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
[CrossRef] [PubMed]

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, “Confidence intervals on fit parameters derived from optical reflectance spectroscopy measurements,” J. Biomed. Opt. 13(5), 054044 (2008).
[CrossRef] [PubMed]

A. Amelink, A. van der Ploeg van den Heuvel, W. J. de Wolf, D. J. Robinson, and H. J. C. M. Sterenborg, “Monitoring PDT by means of superficial reflectance spectroscopy,” J. Photochem. Photobiol. B 79(3), 243–251 (2005).
[CrossRef] [PubMed]

M. P. Bard, A. Amelink, V. N. Hegt, W. J. Graveland, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts, “Measurement of hypoxia-related parameters in bronchial mucosa by use of optical spectroscopy,” Am. J. Respir. Crit. Care Med. 171(10), 1178–1184 (2005).
[CrossRef] [PubMed]

R. L. P. van Veen, A. Amelink, M. Menke-Pluymers, C. van der Pol, and H. J. C. M. Sterenborg, “Optical biopsy of breast tissue using differential path-length spectroscopy,” Phys. Med. Biol. 50(11), 2573–2581 (2005).
[CrossRef] [PubMed]

R. L. P. van Veen, H. J. C. M. Sterenborg, A. Pifferi, A. Torricelli, E. Chikoidze, and R. Cubeddu, “Determination of visible near-IR absorption coefficients of mammalian fat using time- and spatially resolved diffuse reflectance and transmission spectroscopy,” J. Biomed. Opt. 10(5), 054004 (2005).
[CrossRef] [PubMed]

A. Amelink, H. J. C. M. Sterenborg, M. P. L. Bard, and S. A. Burgers, “In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy,” Opt. Lett. 29(10), 1087–1089 (2004).
[CrossRef] [PubMed]

R. L. P. van Veen, W. Verkruysse, and H. J. C. M. Sterenborg, “Diffuse-reflectance spectroscopy from 500 to 1060 nm by correction for inhomogeneously distributed absorbers,” Opt. Lett. 27(4), 246–248 (2002).
[CrossRef] [PubMed]

Svanberg, S.

Taroni, P.

A. Pifferi, A. Torricelli, P. Taroni, A. Bassi, E. Chikoidze, E. Giambattistelli, and R. Cubeddu, “Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies,” J. Biomed. Opt. 9(3), 474–480 (2004).
[CrossRef] [PubMed]

Tittel, F. K.

Torricelli, A.

R. L. P. van Veen, H. J. C. M. Sterenborg, A. Pifferi, A. Torricelli, E. Chikoidze, and R. Cubeddu, “Determination of visible near-IR absorption coefficients of mammalian fat using time- and spatially resolved diffuse reflectance and transmission spectroscopy,” J. Biomed. Opt. 10(5), 054004 (2005).
[CrossRef] [PubMed]

A. Pifferi, A. Torricelli, P. Taroni, A. Bassi, E. Chikoidze, E. Giambattistelli, and R. Cubeddu, “Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies,” J. Biomed. Opt. 9(3), 474–480 (2004).
[CrossRef] [PubMed]

Tromberg, B. J.

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, and O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

Van Dam, J.

van der Mark, M. B.

R. Nachabé, B. H. W. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. C. M. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1,600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
[CrossRef] [PubMed]

van der Ploeg van den Heuvel, A.

A. Amelink, A. van der Ploeg van den Heuvel, W. J. de Wolf, D. J. Robinson, and H. J. C. M. Sterenborg, “Monitoring PDT by means of superficial reflectance spectroscopy,” J. Photochem. Photobiol. B 79(3), 243–251 (2005).
[CrossRef] [PubMed]

van der Pol, C.

R. L. P. van Veen, A. Amelink, M. Menke-Pluymers, C. van der Pol, and H. J. C. M. Sterenborg, “Optical biopsy of breast tissue using differential path-length spectroscopy,” Phys. Med. Biol. 50(11), 2573–2581 (2005).
[CrossRef] [PubMed]

van der Voort, M.

R. Nachabé, B. H. W. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. C. M. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1,600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
[CrossRef] [PubMed]

van Gemert, M. J. C.

W. Verkruysse, G. W. Lucassen, J. F. de Boer, D. J. Smithies, J. S. Nelson, and M. J. C. van Gemert, “Modelling light distributions of homogeneous versus discrete absorbers in light irradiated turbid media,” Phys. Med. Biol. 42(1), 51–65 (1997).
[CrossRef] [PubMed]

H. J. van Staveren, C. J. M. Moes, J. van Marie, S. A. Prahl, and M. J. C. van Gemert, “Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm,” Appl. Opt. 30(31), 4507–4514 (1991).
[CrossRef] [PubMed]

van Marie, J.

van Staveren, H. J.

van Veen, R. L. P.

R. L. P. van Veen, A. Amelink, M. Menke-Pluymers, C. van der Pol, and H. J. C. M. Sterenborg, “Optical biopsy of breast tissue using differential path-length spectroscopy,” Phys. Med. Biol. 50(11), 2573–2581 (2005).
[CrossRef] [PubMed]

R. L. P. van Veen, H. J. C. M. Sterenborg, A. Pifferi, A. Torricelli, E. Chikoidze, and R. Cubeddu, “Determination of visible near-IR absorption coefficients of mammalian fat using time- and spatially resolved diffuse reflectance and transmission spectroscopy,” J. Biomed. Opt. 10(5), 054004 (2005).
[CrossRef] [PubMed]

R. L. P. van Veen, W. Verkruysse, and H. J. C. M. Sterenborg, “Diffuse-reflectance spectroscopy from 500 to 1060 nm by correction for inhomogeneously distributed absorbers,” Opt. Lett. 27(4), 246–248 (2002).
[CrossRef] [PubMed]

Verkruysse, W.

R. L. P. van Veen, W. Verkruysse, and H. J. C. M. Sterenborg, “Diffuse-reflectance spectroscopy from 500 to 1060 nm by correction for inhomogeneously distributed absorbers,” Opt. Lett. 27(4), 246–248 (2002).
[CrossRef] [PubMed]

W. Verkruysse, G. W. Lucassen, J. F. de Boer, D. J. Smithies, J. S. Nelson, and M. J. C. van Gemert, “Modelling light distributions of homogeneous versus discrete absorbers in light irradiated turbid media,” Phys. Med. Biol. 42(1), 51–65 (1997).
[CrossRef] [PubMed]

Volynskaya, Z.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt. 13(2), 024012 (2008).
[CrossRef] [PubMed]

Walker, S. A.

S. Fantini, M. A. Francechini-Fantini, J. S. Maier, S. A. Walker, B. Barbieri, and E. Gratton, “Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry,” Opt. Eng. 34(1), 32–42 (1995).
[CrossRef]

Wang, N.

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt. 13(2), 024012 (2008).
[CrossRef] [PubMed]

Welch, A. J.

C. M. Gardner, S. L. Jacques, and A. J. Welch, “Light transport in tissue: Accurate expressions for one-dimensional fluence rate and escape function based upon monte carlo simulation,” Lasers Surg. Med. 18(2), 129–138 (1996).
[CrossRef] [PubMed]

Wilke, L. G.

J. Q. Brown, L. G. Wilke, J. Geradts, S. A. Kennedy, G. M. Palmer, and N. Ramanujam, “Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo,” Cancer Res. 69(7), 2919–2926 (2009).
[CrossRef] [PubMed]

Wilson, B.

T. J. Farrell, M. S. Patterson, and B. Wilson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19(4), 879–888 (1992).
[CrossRef] [PubMed]

Zonios, G.

Am. J. Respir. Crit. Care Med. (1)

M. P. Bard, A. Amelink, V. N. Hegt, W. J. Graveland, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts, “Measurement of hypoxia-related parameters in bronchial mucosa by use of optical spectroscopy,” Am. J. Respir. Crit. Care Med. 171(10), 1178–1184 (2005).
[CrossRef] [PubMed]

Appl. Opt. (6)

Cancer Res. (1)

J. Q. Brown, L. G. Wilke, J. Geradts, S. A. Kennedy, G. M. Palmer, and N. Ramanujam, “Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo,” Cancer Res. 69(7), 2919–2926 (2009).
[CrossRef] [PubMed]

J. Biomed. Opt. (9)

A. Pifferi, A. Torricelli, P. Taroni, A. Bassi, E. Chikoidze, E. Giambattistelli, and R. Cubeddu, “Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies,” J. Biomed. Opt. 9(3), 474–480 (2004).
[CrossRef] [PubMed]

Z. Volynskaya, A. S. Haka, K. L. Bechtel, M. Fitzmaurice, R. Shenk, N. Wang, J. Nazemi, R. R. Dasari, and M. S. Feld, “Diagnosing breast cancer using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy,” J. Biomed. Opt. 13(2), 024012 (2008).
[CrossRef] [PubMed]

A. E. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J. Biomed. Opt. 11(4), 044005 (2006).
[CrossRef] [PubMed]

I. J. Bigio, S. G. Bown, G. Briggs, C. Kelley, S. Lakhani, D. Pickard, P. M. Ripley, I. G. Rose, and C. Saunders, “Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results,” J. Biomed. Opt. 5(2), 221–228 (2000).
[CrossRef] [PubMed]

R. L. P. van Veen, H. J. C. M. Sterenborg, A. Pifferi, A. Torricelli, E. Chikoidze, and R. Cubeddu, “Determination of visible near-IR absorption coefficients of mammalian fat using time- and spatially resolved diffuse reflectance and transmission spectroscopy,” J. Biomed. Opt. 10(5), 054004 (2005).
[CrossRef] [PubMed]

R. Nachabé, B. H. W. Hendriks, A. E. Desjardins, M. van der Voort, M. B. van der Mark, and H. J. C. M. Sterenborg, “Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1,600 nm,” J. Biomed. Opt. 15(3), 037015 (2010).
[CrossRef] [PubMed]

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, “Confidence intervals on fit parameters derived from optical reflectance spectroscopy measurements,” J. Biomed. Opt. 13(5), 054044 (2008).
[CrossRef] [PubMed]

P. R. Bargo, S. A. Prahl, T. T. Goodell, R. A. Sleven, G. Koval, G. Blair, and S. L. Jacques, “In vivo determination of optical properties of normal and tumor tissue with white light reflectance and an empirical light transport model during endoscopy,” J. Biomed. Opt. 10(3), 034018 (2005).
[CrossRef] [PubMed]

A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, “Optical properties of circulating human blood in the wavelength range of 400-2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

J. Photochem. Photobiol. B (1)

A. Amelink, A. van der Ploeg van den Heuvel, W. J. de Wolf, D. J. Robinson, and H. J. C. M. Sterenborg, “Monitoring PDT by means of superficial reflectance spectroscopy,” J. Photochem. Photobiol. B 79(3), 243–251 (2005).
[CrossRef] [PubMed]

Lasers Surg. Med. (1)

C. M. Gardner, S. L. Jacques, and A. J. Welch, “Light transport in tissue: Accurate expressions for one-dimensional fluence rate and escape function based upon monte carlo simulation,” Lasers Surg. Med. 18(2), 129–138 (1996).
[CrossRef] [PubMed]

Med. Phys. (1)

T. J. Farrell, M. S. Patterson, and B. Wilson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19(4), 879–888 (1992).
[CrossRef] [PubMed]

Opt. Eng. (1)

S. Fantini, M. A. Francechini-Fantini, J. S. Maier, S. A. Walker, B. Barbieri, and E. Gratton, “Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry,” Opt. Eng. 34(1), 32–42 (1995).
[CrossRef]

Opt. Express (2)

Opt. Lett. (3)

Phys. Med. Biol. (2)

R. L. P. van Veen, A. Amelink, M. Menke-Pluymers, C. van der Pol, and H. J. C. M. Sterenborg, “Optical biopsy of breast tissue using differential path-length spectroscopy,” Phys. Med. Biol. 50(11), 2573–2581 (2005).
[CrossRef] [PubMed]

W. Verkruysse, G. W. Lucassen, J. F. de Boer, D. J. Smithies, J. S. Nelson, and M. J. C. van Gemert, “Modelling light distributions of homogeneous versus discrete absorbers in light irradiated turbid media,” Phys. Med. Biol. 42(1), 51–65 (1997).
[CrossRef] [PubMed]

Technol. Cancer Res. Treat. (1)

S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg, and O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol. Cancer Res. Treat. 2(6), 563–569 (2003).
[PubMed]

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P. R. Bevington, and D. K. Robinson, Data Reduction and Error Analysis for the Physical Sciences (McGraw-Hill, New York, 1969).

D. Sheskin, Handbook of Parametric and Non parametric Statistical Procedures (Chapman and Hall/CRC, 2007).

W. G. Zijlstra, A. Buursma, and O. W. Van Assendelft, Visible and Near Infrared Absorption Spectra of Human and Animal Haemoglobin (Utrecht, The Netherlands, VSP Publishing, 2000).

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Figures (6)

Fig. 1
Fig. 1

Sketch of the optical setup: it consists of a halogen lamp that is connected to a fiber and two spectrometers that are connected to two separate fibers that are located next to each other at the tip of the probe.

Fig. 2
Fig. 2

Absorption coefficient of deoxygenated hemoglobin (full line), oxygenated hemoglobin (dashed line), water (dotted line) and lipid (dashed-dotted line) from 500 to 1600 nm.

Fig. 3
Fig. 3

Typical measurement of muscle and fat layer (dotted line), and the corresponding fits and residuals between 500 and 1600 nm (full line).

Fig. 4
Fig. 4

Estimated water and lipid volume fraction (dots) when fitting between 500 and 1000 nm versus 500 and 1000 nm and the respective mean and standard deviation.

Fig. 5
Fig. 5

Comparison of confidence intervals obtained when fit is applied between 500 and 1000 nm and 500 and 1600 nm of the blood volume fraction (stars), blood saturation (circles), water and lipid volume fraction (crosses) and lipid fraction in the total volume (squares).

Fig. 6
Fig. 6

Comparison of the estimated reduced scattering amplitude when fit is applied between 500 and 1000 nm (Fit 1) and 500 and 1600 nm (Fit 2) where the circles correspond to no statistical difference in absolute values and the crosses with statistical differences (a). The corresponding water and lipid volume fractions shows larger deviation from 100% when Fit 1 is applied (b). The corresponding blood volume fraction shows overestimations of the values when Fit 1 is applied (c).

Tables (2)

Tables Icon

Table 1 Average estimated parameters and the corresponding average confidence intervals for fat layers and muscle as derived from fitting over I500→1000 (Fit 1) and I500→1600 (Fit 2)

Tables Icon

Table 2 Spearman’s correlation rank for each estimated parameter and parameters that show significant differences in value and dispersion

Equations (4)

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μ s , ( λ ) = a ( ρ M R ( λ λ 0 ) b + ( 1 ρ M R ) ( λ λ 0 ) 4 ) .
μ a ( λ ) = C ( λ ) ν B L μ a B l o o d ( λ ) + ν W L ( ( 1 α W L ) μ a W a t e r ( λ ) + α W L μ a L i p i d ( λ ) ) .
C ( λ ) = 1 exp ( 2 R μ a B l o o d ( λ ) ) 2 R μ a B l o o d ( λ )
μ a B l o o d ( λ ) = α B L μ a H b O 2 ( λ ) + ( 1 α B L ) μ a H b ( λ ) .

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