Abstract

Intracoronary optical frequency domain imaging (OFDI) provides high resolution, three-dimensional views of coronary artery microstructure, but requires a non-occlusive saline/contrast purge to displace blood for clear artery views. Recent studies utilized manual pullback initiation/termination based on real-time image observation. Automated pullback initiation/termination by real-time OFDI signal analysis would enable more efficient data acquisition. We evaluate the use of simple imaging parameters to automatically and robustly differentiate between diagnostic-quality clear artery wall (CAW) versus blood-obstructed fields (BOF). Algorithms are tested using intracoronary OCT human data retrospectively and intracoronary OFDI swine and human data prospectively. In prospective analysis of OFDI swine data, the sensitivity and specificity of the ratio of second and first moments (contrast parameter) were 99.6% and 97.2%, respectively. In prospective analysis of OFDI clinical data, the contrast parameter yielded 96.0% sensitivity and 94.5% specificity. Accuracy improved further by analyzing sequential frames. These results indicate the algorithm may be utilized with intracoronary OFDI for initiating and terminating automated pullback and digital data recording.

© 2010 OSA

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  1. I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  3. M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I. K. Jang, H. Fujiwara, and G. J. Tearney, “Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques,” J. Am. Coll. Cardiol. 48(1), 81–88 (2006).
    [CrossRef] [PubMed]
  4. G. J. Tearney, I. K. Jang, and B. E. Bouma, “Optical coherence tomography for imaging the vulnerable plaque,” J. Biomed. Opt. 11(2), 021002 (2006).
    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  6. M. E. Brezinski, “Optical coherence tomography for identifying unstable coronary plaque,” Int. J. Cardiol. 107(2), 154–165 (2006).
    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  8. S. Chia, O. Christopher Raffel, M. Takano, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome,” Coron. Artery Dis. 18(6), 423–427 (2007).
    [CrossRef] [PubMed]
  9. M. E. Brezinski, “Applications of optical coherence tomography to cardiac and musculoskeletal diseases: bench to bedside?” J. Biomed. Opt. 12(5), 051705 (2007).
    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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  15. A. F. Low, Y. Kawase, Y. H. Chan, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography,” EuroIntervention 4(5), 626–632 (2009).
    [PubMed]
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    [CrossRef] [PubMed]
  17. F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]

2010

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

2009

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

P. Barlis and J. M. Schmitt, “Current and future developments in intracoronary optical coherence tomography imaging,” EuroIntervention 4(4), 529–533 (2009).
[PubMed]

A. F. Low, Y. Kawase, Y. H. Chan, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography,” EuroIntervention 4(5), 626–632 (2009).
[PubMed]

P. Barlis, G. van Soest, P. W. Serruys, and E. Regar, “Intracoronary optical coherence tomography and the evaluation of stents,” Expert Rev. Med. Devices 6(2), 157–167 (2009).
[CrossRef] [PubMed]

2008

M. Takano, I. K. Jang, S. Inami, M. Yamamoto, D. Murakami, K. Okamatsu, K. Seimiya, T. Ohba, and K. Mizuno, “In vivo comparison of optical coherence tomography and angioscopy for the evaluation of coronary plaque characteristics,” Am. J. Cardiol. 101(4), 471–476 (2008).
[CrossRef] [PubMed]

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

2007

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

S. Chia, O. Christopher Raffel, M. Takano, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome,” Coron. Artery Dis. 18(6), 423–427 (2007).
[CrossRef] [PubMed]

M. E. Brezinski, “Applications of optical coherence tomography to cardiac and musculoskeletal diseases: bench to bedside?” J. Biomed. Opt. 12(5), 051705 (2007).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

2006

M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I. K. Jang, H. Fujiwara, and G. J. Tearney, “Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques,” J. Am. Coll. Cardiol. 48(1), 81–88 (2006).
[CrossRef] [PubMed]

G. J. Tearney, I. K. Jang, and B. E. Bouma, “Optical coherence tomography for imaging the vulnerable plaque,” J. Biomed. Opt. 11(2), 021002 (2006).
[CrossRef] [PubMed]

D. Stamper, N. J. Weissman, and M. Brezinski, “Plaque characterization with optical coherence tomography,” J. Am. Coll. Cardiol. 47(8Suppl), C69–C79 (2006).
[CrossRef] [PubMed]

M. E. Brezinski, “Optical coherence tomography for identifying unstable coronary plaque,” Int. J. Cardiol. 107(2), 154–165 (2006).
[CrossRef] [PubMed]

2005

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

B. D. MacNeill, B. E. Bouma, H. Yabushita, I. K. Jang, and G. J. Tearney, “Intravascular optical coherence tomography: cellular imaging,” J. Nucl. Cardiol. 12(4), 460–465 (2005).
[CrossRef] [PubMed]

2003

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

Akasaka, T.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Arbustini, E.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

Aretz, H. T.

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

Barlis, P.

P. Barlis, G. van Soest, P. W. Serruys, and E. Regar, “Intracoronary optical coherence tomography and the evaluation of stents,” Expert Rev. Med. Devices 6(2), 157–167 (2009).
[CrossRef] [PubMed]

P. Barlis and J. M. Schmitt, “Current and future developments in intracoronary optical coherence tomography imaging,” EuroIntervention 4(4), 529–533 (2009).
[PubMed]

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

Bartlett, L. A.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

Bouma, B. E.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

A. F. Low, Y. Kawase, Y. H. Chan, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography,” EuroIntervention 4(5), 626–632 (2009).
[PubMed]

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

S. Chia, O. Christopher Raffel, M. Takano, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome,” Coron. Artery Dis. 18(6), 423–427 (2007).
[CrossRef] [PubMed]

G. J. Tearney, I. K. Jang, and B. E. Bouma, “Optical coherence tomography for imaging the vulnerable plaque,” J. Biomed. Opt. 11(2), 021002 (2006).
[CrossRef] [PubMed]

M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I. K. Jang, H. Fujiwara, and G. J. Tearney, “Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques,” J. Am. Coll. Cardiol. 48(1), 81–88 (2006).
[CrossRef] [PubMed]

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

B. D. MacNeill, B. E. Bouma, H. Yabushita, I. K. Jang, and G. J. Tearney, “Intravascular optical coherence tomography: cellular imaging,” J. Nucl. Cardiol. 12(4), 460–465 (2005).
[CrossRef] [PubMed]

Bressner, J.

M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I. K. Jang, H. Fujiwara, and G. J. Tearney, “Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques,” J. Am. Coll. Cardiol. 48(1), 81–88 (2006).
[CrossRef] [PubMed]

Brezinski, M.

D. Stamper, N. J. Weissman, and M. Brezinski, “Plaque characterization with optical coherence tomography,” J. Am. Coll. Cardiol. 47(8Suppl), C69–C79 (2006).
[CrossRef] [PubMed]

Brezinski, M. E.

M. E. Brezinski, “Applications of optical coherence tomography to cardiac and musculoskeletal diseases: bench to bedside?” J. Biomed. Opt. 12(5), 051705 (2007).
[CrossRef] [PubMed]

M. E. Brezinski, “Optical coherence tomography for identifying unstable coronary plaque,” Int. J. Cardiol. 107(2), 154–165 (2006).
[CrossRef] [PubMed]

Buellesfeld, L.

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

Cera, M.

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

Chan, R. C.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Chan, Y. H.

A. F. Low, Y. Kawase, Y. H. Chan, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography,” EuroIntervention 4(5), 626–632 (2009).
[PubMed]

Chia, S.

S. Chia, O. Christopher Raffel, M. Takano, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome,” Coron. Artery Dis. 18(6), 423–427 (2007).
[CrossRef] [PubMed]

Christopher Raffel, O.

S. Chia, O. Christopher Raffel, M. Takano, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome,” Coron. Artery Dis. 18(6), 423–427 (2007).
[CrossRef] [PubMed]

Costa, M.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

Dalby, M. C.

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

de Boer, J. F.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Desjardins, A. E.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Di Mario, C.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

Evans, J. A.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Ferrante, G.

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

Freilich, M. I.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

Fujiwara, H.

M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I. K. Jang, H. Fujiwara, and G. J. Tearney, “Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques,” J. Am. Coll. Cardiol. 48(1), 81–88 (2006).
[CrossRef] [PubMed]

Fuster, V.

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

Goderie, T.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

Gonzalo, N.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

Grube, E.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

Guagliumi, G.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

Halpern, E. F.

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

Houser, S.

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

Houser, S. L.

M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I. K. Jang, H. Fujiwara, and G. J. Tearney, “Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques,” J. Am. Coll. Cardiol. 48(1), 81–88 (2006).
[CrossRef] [PubMed]

Iftima, N.

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

Imanishi, T.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Inami, S.

M. Takano, I. K. Jang, S. Inami, M. Yamamoto, D. Murakami, K. Okamatsu, K. Seimiya, T. Ohba, and K. Mizuno, “In vivo comparison of optical coherence tomography and angioscopy for the evaluation of coronary plaque characteristics,” Am. J. Cardiol. 101(4), 471–476 (2008).
[CrossRef] [PubMed]

Jang, I. K.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

A. F. Low, Y. Kawase, Y. H. Chan, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography,” EuroIntervention 4(5), 626–632 (2009).
[PubMed]

M. Takano, I. K. Jang, S. Inami, M. Yamamoto, D. Murakami, K. Okamatsu, K. Seimiya, T. Ohba, and K. Mizuno, “In vivo comparison of optical coherence tomography and angioscopy for the evaluation of coronary plaque characteristics,” Am. J. Cardiol. 101(4), 471–476 (2008).
[CrossRef] [PubMed]

S. Chia, O. Christopher Raffel, M. Takano, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome,” Coron. Artery Dis. 18(6), 423–427 (2007).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I. K. Jang, H. Fujiwara, and G. J. Tearney, “Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques,” J. Am. Coll. Cardiol. 48(1), 81–88 (2006).
[CrossRef] [PubMed]

G. J. Tearney, I. K. Jang, and B. E. Bouma, “Optical coherence tomography for imaging the vulnerable plaque,” J. Biomed. Opt. 11(2), 021002 (2006).
[CrossRef] [PubMed]

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

B. D. MacNeill, B. E. Bouma, H. Yabushita, I. K. Jang, and G. J. Tearney, “Intravascular optical coherence tomography: cellular imaging,” J. Nucl. Cardiol. 12(4), 460–465 (2005).
[CrossRef] [PubMed]

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

Kawasaki, M.

M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I. K. Jang, H. Fujiwara, and G. J. Tearney, “Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques,” J. Am. Coll. Cardiol. 48(1), 81–88 (2006).
[CrossRef] [PubMed]

Kawase, Y.

A. F. Low, Y. Kawase, Y. H. Chan, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography,” EuroIntervention 4(5), 626–632 (2009).
[PubMed]

Kitabata, H.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Koljenovic, S.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

Kubo, T.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Kuroi, A.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Low, A. F.

A. F. Low, Y. Kawase, Y. H. Chan, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography,” EuroIntervention 4(5), 626–632 (2009).
[PubMed]

Lowe, H. C.

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

MacNeill, B.

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

MacNeill, B. D.

M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I. K. Jang, H. Fujiwara, and G. J. Tearney, “Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques,” J. Am. Coll. Cardiol. 48(1), 81–88 (2006).
[CrossRef] [PubMed]

B. D. MacNeill, B. E. Bouma, H. Yabushita, I. K. Jang, and G. J. Tearney, “Intravascular optical coherence tomography: cellular imaging,” J. Nucl. Cardiol. 12(4), 460–465 (2005).
[CrossRef] [PubMed]

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

Masho, T.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Matsuo, Y.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Mintz, G. S.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

Mizuno, K.

M. Takano, I. K. Jang, S. Inami, M. Yamamoto, D. Murakami, K. Okamatsu, K. Seimiya, T. Ohba, and K. Mizuno, “In vivo comparison of optical coherence tomography and angioscopy for the evaluation of coronary plaque characteristics,” Am. J. Cardiol. 101(4), 471–476 (2008).
[CrossRef] [PubMed]

Moselewski, F.

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

Murakami, D.

M. Takano, I. K. Jang, S. Inami, M. Yamamoto, D. Murakami, K. Okamatsu, K. Seimiya, T. Ohba, and K. Mizuno, “In vivo comparison of optical coherence tomography and angioscopy for the evaluation of coronary plaque characteristics,” Am. J. Cardiol. 101(4), 471–476 (2008).
[CrossRef] [PubMed]

Nadkarni, S. K.

M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I. K. Jang, H. Fujiwara, and G. J. Tearney, “Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques,” J. Am. Coll. Cardiol. 48(1), 81–88 (2006).
[CrossRef] [PubMed]

Nishioka, N. S.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Oh, W. Y.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Ohba, T.

M. Takano, I. K. Jang, S. Inami, M. Yamamoto, D. Murakami, K. Okamatsu, K. Seimiya, T. Ohba, and K. Mizuno, “In vivo comparison of optical coherence tomography and angioscopy for the evaluation of coronary plaque characteristics,” Am. J. Cardiol. 101(4), 471–476 (2008).
[CrossRef] [PubMed]

Okamatsu, K.

M. Takano, I. K. Jang, S. Inami, M. Yamamoto, D. Murakami, K. Okamatsu, K. Seimiya, T. Ohba, and K. Mizuno, “In vivo comparison of optical coherence tomography and angioscopy for the evaluation of coronary plaque characteristics,” Am. J. Cardiol. 101(4), 471–476 (2008).
[CrossRef] [PubMed]

Okamura, T.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

Oosterhuis, J. W.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

Ozaki, Y.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

Pinto, F.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

Prati, F.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

Regar, E.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

P. Barlis, G. van Soest, P. W. Serruys, and E. Regar, “Intracoronary optical coherence tomography and the evaluation of stents,” Expert Rev. Med. Devices 6(2), 157–167 (2009).
[CrossRef] [PubMed]

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

Rieber, J.

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

Rosenberg, M.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

Schmitt, J. M.

P. Barlis and J. M. Schmitt, “Current and future developments in intracoronary optical coherence tomography imaging,” EuroIntervention 4(4), 529–533 (2009).
[PubMed]

Seimiya, K.

M. Takano, I. K. Jang, S. Inami, M. Yamamoto, D. Murakami, K. Okamatsu, K. Seimiya, T. Ohba, and K. Mizuno, “In vivo comparison of optical coherence tomography and angioscopy for the evaluation of coronary plaque characteristics,” Am. J. Cardiol. 101(4), 471–476 (2008).
[CrossRef] [PubMed]

Serruys, P. W.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

P. Barlis, G. van Soest, P. W. Serruys, and E. Regar, “Intracoronary optical coherence tomography and the evaluation of stents,” Expert Rev. Med. Devices 6(2), 157–167 (2009).
[CrossRef] [PubMed]

Shishkov, M.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

Stamper, D.

D. Stamper, N. J. Weissman, and M. Brezinski, “Plaque characterization with optical coherence tomography,” J. Am. Coll. Cardiol. 47(8Suppl), C69–C79 (2006).
[CrossRef] [PubMed]

Suter, M. J.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Takano, M.

M. Takano, I. K. Jang, S. Inami, M. Yamamoto, D. Murakami, K. Okamatsu, K. Seimiya, T. Ohba, and K. Mizuno, “In vivo comparison of optical coherence tomography and angioscopy for the evaluation of coronary plaque characteristics,” Am. J. Cardiol. 101(4), 471–476 (2008).
[CrossRef] [PubMed]

S. Chia, O. Christopher Raffel, M. Takano, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome,” Coron. Artery Dis. 18(6), 423–427 (2007).
[CrossRef] [PubMed]

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

Takarada, S.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Tanimoto, T.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Tearney, G. J.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

A. F. Low, Y. Kawase, Y. H. Chan, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography,” EuroIntervention 4(5), 626–632 (2009).
[PubMed]

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

S. Chia, O. Christopher Raffel, M. Takano, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome,” Coron. Artery Dis. 18(6), 423–427 (2007).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I. K. Jang, H. Fujiwara, and G. J. Tearney, “Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques,” J. Am. Coll. Cardiol. 48(1), 81–88 (2006).
[CrossRef] [PubMed]

G. J. Tearney, I. K. Jang, and B. E. Bouma, “Optical coherence tomography for imaging the vulnerable plaque,” J. Biomed. Opt. 11(2), 021002 (2006).
[CrossRef] [PubMed]

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

B. D. MacNeill, B. E. Bouma, H. Yabushita, I. K. Jang, and G. J. Tearney, “Intravascular optical coherence tomography: cellular imaging,” J. Nucl. Cardiol. 12(4), 460–465 (2005).
[CrossRef] [PubMed]

Tomobuchi, Y.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Tsuda, K.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Ueno, S.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Vakoc, B. J.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

van der Steen, A. F.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

van Leenders, G. L.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

van Noorden, S.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

van Soest, G.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

P. Barlis, G. van Soest, P. W. Serruys, and E. Regar, “Intracoronary optical coherence tomography and the evaluation of stents,” Expert Rev. Med. Devices 6(2), 157–167 (2009).
[CrossRef] [PubMed]

Waxman, S.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

Weissman, N. J.

D. Stamper, N. J. Weissman, and M. Brezinski, “Plaque characterization with optical coherence tomography,” J. Am. Coll. Cardiol. 47(8Suppl), C69–C79 (2006).
[CrossRef] [PubMed]

Yabushita, H.

B. D. MacNeill, B. E. Bouma, H. Yabushita, I. K. Jang, and G. J. Tearney, “Intravascular optical coherence tomography: cellular imaging,” J. Nucl. Cardiol. 12(4), 460–465 (2005).
[CrossRef] [PubMed]

Yamamoto, M.

M. Takano, I. K. Jang, S. Inami, M. Yamamoto, D. Murakami, K. Okamatsu, K. Seimiya, T. Ohba, and K. Mizuno, “In vivo comparison of optical coherence tomography and angioscopy for the evaluation of coronary plaque characteristics,” Am. J. Cardiol. 101(4), 471–476 (2008).
[CrossRef] [PubMed]

Yamano, T.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

Yun, S. H.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Am. J. Cardiol.

M. Takano, I. K. Jang, S. Inami, M. Yamamoto, D. Murakami, K. Okamatsu, K. Seimiya, T. Ohba, and K. Mizuno, “In vivo comparison of optical coherence tomography and angioscopy for the evaluation of coronary plaque characteristics,” Am. J. Cardiol. 101(4), 471–476 (2008).
[CrossRef] [PubMed]

Arterioscler. Thromb. Vasc. Biol.

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

Circulation

I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005).
[CrossRef] [PubMed]

Coron. Artery Dis.

S. Chia, O. Christopher Raffel, M. Takano, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome,” Coron. Artery Dis. 18(6), 423–427 (2007).
[CrossRef] [PubMed]

Eur. Heart J.

F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I. K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, Y. Ozaki, F. Pinto, and P. W. Serruys, “Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis,” Eur. Heart J. 31(4), 401–415 (2010).
[CrossRef] [PubMed]

EuroIntervention

P. Barlis, N. Gonzalo, C. Di Mario, F. Prati, L. Buellesfeld, J. Rieber, M. C. Dalby, G. Ferrante, M. Cera, E. Grube, P. W. Serruys, and E. Regar, “A multicentre evaluation of the safety of intracoronary optical coherence tomography,” EuroIntervention 5(1), 90–95 (2009).
[PubMed]

P. Barlis and J. M. Schmitt, “Current and future developments in intracoronary optical coherence tomography imaging,” EuroIntervention 4(4), 529–533 (2009).
[PubMed]

A. F. Low, Y. Kawase, Y. H. Chan, G. J. Tearney, B. E. Bouma, and I. K. Jang, “In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography,” EuroIntervention 4(5), 626–632 (2009).
[PubMed]

Expert Rev. Med. Devices

P. Barlis, G. van Soest, P. W. Serruys, and E. Regar, “Intracoronary optical coherence tomography and the evaluation of stents,” Expert Rev. Med. Devices 6(2), 157–167 (2009).
[CrossRef] [PubMed]

Int. J. Cardiol.

M. E. Brezinski, “Optical coherence tomography for identifying unstable coronary plaque,” Int. J. Cardiol. 107(2), 154–165 (2006).
[CrossRef] [PubMed]

J. Am. Coll. Cardiol.

T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, K. Tsuda, Y. Tomobuchi, and T. Akasaka, “Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy,” J. Am. Coll. Cardiol. 50(10), 933–939 (2007).
[CrossRef] [PubMed]

M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I. K. Jang, H. Fujiwara, and G. J. Tearney, “Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques,” J. Am. Coll. Cardiol. 48(1), 81–88 (2006).
[CrossRef] [PubMed]

D. Stamper, N. J. Weissman, and M. Brezinski, “Plaque characterization with optical coherence tomography,” J. Am. Coll. Cardiol. 47(8Suppl), C69–C79 (2006).
[CrossRef] [PubMed]

J. Biomed. Opt.

G. van Soest, T. Goderie, E. Regar, S. Koljenović, G. L. van Leenders, N. Gonzalo, S. van Noorden, T. Okamura, B. E. Bouma, G. J. Tearney, J. W. Oosterhuis, P. W. Serruys, and A. F. van der Steen, “Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging,” J. Biomed. Opt. 15(1), 011105 (2010).
[CrossRef] [PubMed]

G. J. Tearney, I. K. Jang, and B. E. Bouma, “Optical coherence tomography for imaging the vulnerable plaque,” J. Biomed. Opt. 11(2), 021002 (2006).
[CrossRef] [PubMed]

M. E. Brezinski, “Applications of optical coherence tomography to cardiac and musculoskeletal diseases: bench to bedside?” J. Biomed. Opt. 12(5), 051705 (2007).
[CrossRef] [PubMed]

J. Nucl. Cardiol.

B. D. MacNeill, B. E. Bouma, H. Yabushita, I. K. Jang, and G. J. Tearney, “Intravascular optical coherence tomography: cellular imaging,” J. Nucl. Cardiol. 12(4), 460–465 (2005).
[CrossRef] [PubMed]

JACC Cardiovasc. Imaging

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging 1(6), 752–761 (2008).
[CrossRef] [PubMed]

Nat. Med.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

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Figures (3)

Fig. 1
Fig. 1

Intracoronary OCT images from human coronary artery and their classifications. A. Clear artery wall. The catheter sheath is denoted by an arrow. B. Blood obstructed field. C. Blood-wall mixing. D. Guide catheter. Images are displayed with an inverse gray scale LUT. The asterisk (“*”) denotes the guide wire artifact. Scale bar, 500 µm.

Fig. 2
Fig. 2

Intracoronary OFDI in swine demonstrating algorithm ROI. (a) CP algorithm 33 pixel 1D ROI calculated every A-line or every 5th A-line in clear artery wall and (b) blood obstructed field. (c) Standard deviation algorithm 150 pixel 2D ROI in guide catheter image. Black circles bound ROI for each respective algorithm. Images are displayed with an inverse gray scale LUT. Scale bar, 500 µm.

Fig. 3
Fig. 3

Flow diagram for OFDI pullback storage image feedback and control.

Tables (1)

Tables Icon

Table 1 Error Rates for OFDI Swine and Clinical Data

Equations (1)

Equations on this page are rendered with MathJax. Learn more.

C P = S t D e v ( A l i n e R O I ) M e a n ( A l i n e R O I ) = S e c o n d M o m e n t F i r s t M o m e n t

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