Abstract

This goal of this study was to clinically evaluate the potential of a novel hybrid imaging techniques, called x-ray guided multispectral diffuse optical tomography, for identifying physiological parameters of joint tissues that can be used to distinguish between osteoarthritic and healthy joints in the hand. Between 2006 and 2009, the distal interphalangeal (DIP) finger joints from 40 subjects including 22 osteoarthritis patients and 18 healthy controls were examined clinically and scanned by the hybrid imaging platform that integrated a C-arm based x-ray tomosynthetic system with a mutlispectral diffuse optical imaging system. Based on the reconstructed results from the 40 subjects, it was observed that oxygen saturation and water content were two statistically most significant physiological discriminators for differentiation of the healthy joints from the osteoarthritic ones.

© 2010 OSA

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2009

D. Elewaut and M. Matucci-Cerinic, “Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice,” Rheumatology (Oxford) 48(9), 1029–1035 (2009).
[CrossRef] [PubMed]

Z. Yuan, Q. Zhang, E. Sobel, and H. Jiang, “Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis,” J. Biomed. Opt. 14(5), 054013 (2009).
[CrossRef] [PubMed]

2008

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

Z. Yuan, Q. Zhang, E. S. Sobel, and H. Jiang, “Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints,” J. Biomed. Opt. 13(4), 044006 (2008).
[CrossRef] [PubMed]

2007

Z. Yuan, Q. Zhang, E. Sobel, and H. Jiang, “Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints,” J. Biomed. Opt. 12(3), 034001 (2007).
[CrossRef] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

E. M. Hillman, “Optical brain imaging in vivo: techniques and applications from animal to man,” J. Biomed. Opt. 12(5), 051402 (2007).
[CrossRef] [PubMed]

J. P. Mansell, C. Collins, and A. J. Bailey, “Bone, not cartilage, should be the major focus in osteoarthritis,” Nat. Clin. Pract. Rheumatol. 3(6), 306–307 (2007).
[CrossRef] [PubMed]

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Z. Yuan and H. Jiang, “Three-dimensional finite-element-based photoacoustic tomography: reconstruction algorithm and simulations,” Med. Phys. 34(2), 538–546 (2007).
[CrossRef] [PubMed]

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[CrossRef] [PubMed]

2006

S. B. Abramson, M. Attur, and Y. Yazici, “Prospects for disease modification in osteoarthritis,” Nat. Clin. Pract. Rheumatol. 2(6), 304–312 (2006).
[CrossRef] [PubMed]

2005

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissues: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[CrossRef]

P. Sarzi-Puttini, M. A. Cimmino, R. Scarpa, R. Caporali, F. Parazzini, A. Zaninelli, F. Atzeni, and B. Canesi, “Osteoarthritis: an overview of the disease and its treatment strategies,” Semin. Arthritis Rheum. 35(1Suppl 1), 1–10 (2005).
[CrossRef] [PubMed]

J. C. Hebden, T. D. Yates, A. Gibson, N. Everdell, S. R. Arridge, D. W. Chicken, M. Douek, and M. R. Keshtgar, “Monitoring recovery after laser surgery of the breast with optical tomography: a case study,” Appl. Opt. 44(10), 1898–1904 (2005).
[CrossRef] [PubMed]

2004

A. Li, Q. Zhang, J. P. Culver, E. L. Miller, and D. A. Boas, “Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography,” Opt. Lett. 29(3), 256–258 (2004).
[CrossRef] [PubMed]

F. J. Blanco, M. J. López-Armada, and E. Maneiro, “Mitochondrial dysfunction in osteoarthritis,” Mitochondrion 4(5-6), 715–728 (2004).
[CrossRef] [PubMed]

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[CrossRef] [PubMed]

2003

1999

J. Allen, “Bailey, L. Knott, “Molecular changes in bone collagen in osteoporosis and osteoarthritis in the elderly,” Exp. Gerontol. 24, 337–351 (1999).

1998

I. F. Petersson, T. Boegard, B. Svensson, D. Heinegard, and T. Saxne, Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint,” Br. J. Rheumatol. 37(1), 46–50 (1998).
[CrossRef]

1995

D. J. Hart and T. D. Spector, “Definition and epidemiology of osteoarthritis of the hand: a review,” Osteoarthritis Cartilage 8(Suppl A), S2–S7 (1995).
[CrossRef] [PubMed]

J. A. Tyler, P. J. Watson, H. L. Koh, N. J. Herrod, M. Robson, and L. D. Hall, “Detection and monitoring of progressive degeneration of osteoarthritic cartilage by MRI,” Acta Orthop. Scand. Suppl. 266(Suppl.), 130–138 (1995).
[PubMed]

1991

W. P. Chan, P. Lang, M. P. Stevens, K. Sack, S. Majumdar, D. W. Stoller, C. Basch, and H. K. Genant, “Osteoarthritis of the knee: comparison of radiology, CT, and MR imaging to assess extent and severity,” Am. J. Roe. 157, 799–806 (1991).

1975

H. J. Mankin and A. Z. Thrasher, “Water content and binding in normal and osteoarthritic human cartilage,” J. Bone Joint Surg. Am. 57(1), 76–80 (1975).
[PubMed]

Abramson, S. B.

S. B. Abramson, M. Attur, and Y. Yazici, “Prospects for disease modification in osteoarthritis,” Nat. Clin. Pract. Rheumatol. 2(6), 304–312 (2006).
[CrossRef] [PubMed]

Allen, J.

J. Allen, “Bailey, L. Knott, “Molecular changes in bone collagen in osteoporosis and osteoarthritis in the elderly,” Exp. Gerontol. 24, 337–351 (1999).

Arridge, S. R.

Attur, M.

S. B. Abramson, M. Attur, and Y. Yazici, “Prospects for disease modification in osteoarthritis,” Nat. Clin. Pract. Rheumatol. 2(6), 304–312 (2006).
[CrossRef] [PubMed]

Atzeni, F.

P. Sarzi-Puttini, M. A. Cimmino, R. Scarpa, R. Caporali, F. Parazzini, A. Zaninelli, F. Atzeni, and B. Canesi, “Osteoarthritis: an overview of the disease and its treatment strategies,” Semin. Arthritis Rheum. 35(1Suppl 1), 1–10 (2005).
[CrossRef] [PubMed]

Backhaus, M.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Bailey, A. J.

J. P. Mansell, C. Collins, and A. J. Bailey, “Bone, not cartilage, should be the major focus in osteoarthritis,” Nat. Clin. Pract. Rheumatol. 3(6), 306–307 (2007).
[CrossRef] [PubMed]

Baron, G.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Basch, C.

W. P. Chan, P. Lang, M. P. Stevens, K. Sack, S. Majumdar, D. W. Stoller, C. Basch, and H. K. Genant, “Osteoarthritis of the knee: comparison of radiology, CT, and MR imaging to assess extent and severity,” Am. J. Roe. 157, 799–806 (1991).

Birrel, F.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Blanco, F. J.

F. J. Blanco, M. J. López-Armada, and E. Maneiro, “Mitochondrial dysfunction in osteoarthritis,” Mitochondrion 4(5-6), 715–728 (2004).
[CrossRef] [PubMed]

Boas, D. A.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

A. Li, Q. Zhang, J. P. Culver, E. L. Miller, and D. A. Boas, “Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography,” Opt. Lett. 29(3), 256–258 (2004).
[CrossRef] [PubMed]

Boegard, T.

I. F. Petersson, T. Boegard, B. Svensson, D. Heinegard, and T. Saxne, Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint,” Br. J. Rheumatol. 37(1), 46–50 (1998).
[CrossRef]

Brasseur, J. L.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Brooksby, B.

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissues: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[CrossRef]

Burmester, G.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Butler, J.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Canesi, B.

P. Sarzi-Puttini, M. A. Cimmino, R. Scarpa, R. Caporali, F. Parazzini, A. Zaninelli, F. Atzeni, and B. Canesi, “Osteoarthritis: an overview of the disease and its treatment strategies,” Semin. Arthritis Rheum. 35(1Suppl 1), 1–10 (2005).
[CrossRef] [PubMed]

Caporali, R.

P. Sarzi-Puttini, M. A. Cimmino, R. Scarpa, R. Caporali, F. Parazzini, A. Zaninelli, F. Atzeni, and B. Canesi, “Osteoarthritis: an overview of the disease and its treatment strategies,” Semin. Arthritis Rheum. 35(1Suppl 1), 1–10 (2005).
[CrossRef] [PubMed]

Carpenter, C. M.

Cerussi, A.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Cerussi, A. E.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

Chan, W. P.

W. P. Chan, P. Lang, M. P. Stevens, K. Sack, S. Majumdar, D. W. Stoller, C. Basch, and H. K. Genant, “Osteoarthritis of the knee: comparison of radiology, CT, and MR imaging to assess extent and severity,” Am. J. Roe. 157, 799–806 (1991).

Chance, B.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[CrossRef] [PubMed]

Chen, N. G.

Chicken, D. W.

Choe, R.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

A. Corlu, T. Durduran, R. Choe, M. Schweiger, E. M. Hillman, S. R. Arridge, and A. G. Yodh, “Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography,” Opt. Lett. 28(23), 2339–2341 (2003).
[CrossRef] [PubMed]

Cimmino, M. A.

P. Sarzi-Puttini, M. A. Cimmino, R. Scarpa, R. Caporali, F. Parazzini, A. Zaninelli, F. Atzeni, and B. Canesi, “Osteoarthritis: an overview of the disease and its treatment strategies,” Semin. Arthritis Rheum. 35(1Suppl 1), 1–10 (2005).
[CrossRef] [PubMed]

Collins, C.

J. P. Mansell, C. Collins, and A. J. Bailey, “Bone, not cartilage, should be the major focus in osteoarthritis,” Nat. Clin. Pract. Rheumatol. 3(6), 306–307 (2007).
[CrossRef] [PubMed]

Conaghan, P.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Conaghan, P. G.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Corlu, A.

Culver, J. P.

D’Agostino, M. A.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Dehghani, H.

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissues: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[CrossRef]

Douek, M.

Dougados, M.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Durduran, T.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
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A. Corlu, T. Durduran, R. Choe, M. Schweiger, E. M. Hillman, S. R. Arridge, and A. G. Yodh, “Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography,” Opt. Lett. 28(23), 2339–2341 (2003).
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C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Elewaut, D.

D. Elewaut and M. Matucci-Cerinic, “Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice,” Rheumatology (Oxford) 48(9), 1029–1035 (2009).
[CrossRef] [PubMed]

Emery, P.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Everdell, N.

Forero, J.

Genant, H. K.

W. P. Chan, P. Lang, M. P. Stevens, K. Sack, S. Majumdar, D. W. Stoller, C. Basch, and H. K. Genant, “Osteoarthritis of the knee: comparison of radiology, CT, and MR imaging to assess extent and severity,” Am. J. Roe. 157, 799–806 (1991).

Gibson, A.

Grassi, W.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
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H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
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X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
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Hall, L. D.

J. A. Tyler, P. J. Watson, H. L. Koh, N. J. Herrod, M. Robson, and L. D. Hall, “Detection and monitoring of progressive degeneration of osteoarthritic cartilage by MRI,” Acta Orthop. Scand. Suppl. 266(Suppl.), 130–138 (1995).
[PubMed]

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H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
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D. J. Hart and T. D. Spector, “Definition and epidemiology of osteoarthritis of the hand: a review,” Osteoarthritis Cartilage 8(Suppl A), S2–S7 (1995).
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Hebden, J. C.

Heinegard, D.

I. F. Petersson, T. Boegard, B. Svensson, D. Heinegard, and T. Saxne, Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint,” Br. J. Rheumatol. 37(1), 46–50 (1998).
[CrossRef]

Hensor, E.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
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Herrod, N. J.

J. A. Tyler, P. J. Watson, H. L. Koh, N. J. Herrod, M. Robson, and L. D. Hall, “Detection and monitoring of progressive degeneration of osteoarthritic cartilage by MRI,” Acta Orthop. Scand. Suppl. 266(Suppl.), 130–138 (1995).
[PubMed]

Hillman, E. M.

Hsiang, D.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Intes, X.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[CrossRef] [PubMed]

Jiang, H.

Z. Yuan, Q. Zhang, E. Sobel, and H. Jiang, “Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis,” J. Biomed. Opt. 14(5), 054013 (2009).
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Z. Yuan, Q. Zhang, E. S. Sobel, and H. Jiang, “Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints,” J. Biomed. Opt. 13(4), 044006 (2008).
[CrossRef] [PubMed]

Z. Yuan and H. Jiang, “Three-dimensional finite-element-based photoacoustic tomography: reconstruction algorithm and simulations,” Med. Phys. 34(2), 538–546 (2007).
[CrossRef] [PubMed]

Z. Yuan, Q. Zhang, E. Sobel, and H. Jiang, “Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints,” J. Biomed. Opt. 12(3), 034001 (2007).
[CrossRef] [PubMed]

Jiang, S.

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissues: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[CrossRef]

Kane, D.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Kaufman, P. A.

Keen, H. I.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Keshtgar, M. R.

Kloppenburg, M.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Kogel, C.

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissues: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[CrossRef]

Koh, H. L.

J. A. Tyler, P. J. Watson, H. L. Koh, N. J. Herrod, M. Robson, and L. D. Hall, “Detection and monitoring of progressive degeneration of osteoarthritic cartilage by MRI,” Acta Orthop. Scand. Suppl. 266(Suppl.), 130–138 (1995).
[PubMed]

Kortekaas, M. C.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Kurtzman, S. H.

Lang, P.

W. P. Chan, P. Lang, M. P. Stevens, K. Sack, S. Majumdar, D. W. Stoller, C. Basch, and H. K. Genant, “Osteoarthritis of the knee: comparison of radiology, CT, and MR imaging to assess extent and severity,” Am. J. Roe. 157, 799–806 (1991).

Lavie, F.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Le Bars, M.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Li, A.

López-Armada, M. J.

F. J. Blanco, M. J. López-Armada, and E. Maneiro, “Mitochondrial dysfunction in osteoarthritis,” Mitochondrion 4(5-6), 715–728 (2004).
[CrossRef] [PubMed]

Maheu, E.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Majumdar, S.

W. P. Chan, P. Lang, M. P. Stevens, K. Sack, S. Majumdar, D. W. Stoller, C. Basch, and H. K. Genant, “Osteoarthritis of the knee: comparison of radiology, CT, and MR imaging to assess extent and severity,” Am. J. Roe. 157, 799–806 (1991).

Malaise, M.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Maloux, C.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[CrossRef] [PubMed]

Maneiro, E.

F. J. Blanco, M. J. López-Armada, and E. Maneiro, “Mitochondrial dysfunction in osteoarthritis,” Mitochondrion 4(5-6), 715–728 (2004).
[CrossRef] [PubMed]

Mankin, H. J.

H. J. Mankin and A. Z. Thrasher, “Water content and binding in normal and osteoarthritic human cartilage,” J. Bone Joint Surg. Am. 57(1), 76–80 (1975).
[PubMed]

Mansell, J. P.

J. P. Mansell, C. Collins, and A. J. Bailey, “Bone, not cartilage, should be the major focus in osteoarthritis,” Nat. Clin. Pract. Rheumatol. 3(6), 306–307 (2007).
[CrossRef] [PubMed]

Martin-Mola, E.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Matucci-Cerinic, M.

D. Elewaut and M. Matucci-Cerinic, “Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice,” Rheumatology (Oxford) 48(9), 1029–1035 (2009).
[CrossRef] [PubMed]

Mehta, R.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Miller, E. L.

Parazzini, F.

P. Sarzi-Puttini, M. A. Cimmino, R. Scarpa, R. Caporali, F. Parazzini, A. Zaninelli, F. Atzeni, and B. Canesi, “Osteoarthritis: an overview of the disease and its treatment strategies,” Semin. Arthritis Rheum. 35(1Suppl 1), 1–10 (2005).
[CrossRef] [PubMed]

Paulsen, K. D.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissues: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[CrossRef]

Pendleton, A.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Petersson, I. F.

I. F. Petersson, T. Boegard, B. Svensson, D. Heinegard, and T. Saxne, Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint,” Br. J. Rheumatol. 37(1), 46–50 (1998).
[CrossRef]

Pogue, B. W.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissues: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[CrossRef]

Poplack, S. P.

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissues: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[CrossRef]

Ravaud, P.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Robson, M.

J. A. Tyler, P. J. Watson, H. L. Koh, N. J. Herrod, M. Robson, and L. D. Hall, “Detection and monitoring of progressive degeneration of osteoarthritic cartilage by MRI,” Acta Orthop. Scand. Suppl. 266(Suppl.), 130–138 (1995).
[PubMed]

Sack, K.

W. P. Chan, P. Lang, M. P. Stevens, K. Sack, S. Majumdar, D. W. Stoller, C. Basch, and H. K. Genant, “Osteoarthritis of the knee: comparison of radiology, CT, and MR imaging to assess extent and severity,” Am. J. Roe. 157, 799–806 (1991).

Sarzi-Puttini, P.

P. Sarzi-Puttini, M. A. Cimmino, R. Scarpa, R. Caporali, F. Parazzini, A. Zaninelli, F. Atzeni, and B. Canesi, “Osteoarthritis: an overview of the disease and its treatment strategies,” Semin. Arthritis Rheum. 35(1Suppl 1), 1–10 (2005).
[CrossRef] [PubMed]

Saxne, T.

I. F. Petersson, T. Boegard, B. Svensson, D. Heinegard, and T. Saxne, Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint,” Br. J. Rheumatol. 37(1), 46–50 (1998).
[CrossRef]

Scarpa, R.

P. Sarzi-Puttini, M. A. Cimmino, R. Scarpa, R. Caporali, F. Parazzini, A. Zaninelli, F. Atzeni, and B. Canesi, “Osteoarthritis: an overview of the disease and its treatment strategies,” Semin. Arthritis Rheum. 35(1Suppl 1), 1–10 (2005).
[CrossRef] [PubMed]

Schmidely, N.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Schueller-Weidekamm, C.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Schweiger, M.

Shah, N.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Smolen, J. S.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

So, A.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Sobel, E.

Z. Yuan, Q. Zhang, E. Sobel, and H. Jiang, “Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis,” J. Biomed. Opt. 14(5), 054013 (2009).
[CrossRef] [PubMed]

Z. Yuan, Q. Zhang, E. Sobel, and H. Jiang, “Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints,” J. Biomed. Opt. 12(3), 034001 (2007).
[CrossRef] [PubMed]

Sobel, E. S.

Z. Yuan, Q. Zhang, E. S. Sobel, and H. Jiang, “Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints,” J. Biomed. Opt. 13(4), 044006 (2008).
[CrossRef] [PubMed]

Spector, T. D.

D. J. Hart and T. D. Spector, “Definition and epidemiology of osteoarthritis of the hand: a review,” Osteoarthritis Cartilage 8(Suppl A), S2–S7 (1995).
[CrossRef] [PubMed]

Stamm, T.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

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W. P. Chan, P. Lang, M. P. Stevens, K. Sack, S. Majumdar, D. W. Stoller, C. Basch, and H. K. Genant, “Osteoarthritis of the knee: comparison of radiology, CT, and MR imaging to assess extent and severity,” Am. J. Roe. 157, 799–806 (1991).

Stoller, D. W.

W. P. Chan, P. Lang, M. P. Stevens, K. Sack, S. Majumdar, D. W. Stoller, C. Basch, and H. K. Genant, “Osteoarthritis of the knee: comparison of radiology, CT, and MR imaging to assess extent and severity,” Am. J. Roe. 157, 799–806 (1991).

Svensson, B.

I. F. Petersson, T. Boegard, B. Svensson, D. Heinegard, and T. Saxne, Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint,” Br. J. Rheumatol. 37(1), 46–50 (1998).
[CrossRef]

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B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
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C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
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J. A. Tyler, P. J. Watson, H. L. Koh, N. J. Herrod, M. Robson, and L. D. Hall, “Detection and monitoring of progressive degeneration of osteoarthritic cartilage by MRI,” Acta Orthop. Scand. Suppl. 266(Suppl.), 130–138 (1995).
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P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

Wakefield, R. J.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Wang, X.

Watson, P. J.

J. A. Tyler, P. J. Watson, H. L. Koh, N. J. Herrod, M. Robson, and L. D. Hall, “Detection and monitoring of progressive degeneration of osteoarthritic cartilage by MRI,” Acta Orthop. Scand. Suppl. 266(Suppl.), 130–138 (1995).
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Watt, I.

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
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B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissues: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
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Wells, W. A.

Yates, T. D.

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X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
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S. B. Abramson, M. Attur, and Y. Yazici, “Prospects for disease modification in osteoarthritis,” Nat. Clin. Pract. Rheumatol. 2(6), 304–312 (2006).
[CrossRef] [PubMed]

Yodh, A. G.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
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C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

A. Corlu, T. Durduran, R. Choe, M. Schweiger, E. M. Hillman, S. R. Arridge, and A. G. Yodh, “Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography,” Opt. Lett. 28(23), 2339–2341 (2003).
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C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Yuan, Z.

Z. Yuan, Q. Zhang, E. Sobel, and H. Jiang, “Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis,” J. Biomed. Opt. 14(5), 054013 (2009).
[CrossRef] [PubMed]

Z. Yuan, Q. Zhang, E. S. Sobel, and H. Jiang, “Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints,” J. Biomed. Opt. 13(4), 044006 (2008).
[CrossRef] [PubMed]

Z. Yuan, Q. Zhang, E. Sobel, and H. Jiang, “Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints,” J. Biomed. Opt. 12(3), 034001 (2007).
[CrossRef] [PubMed]

Z. Yuan and H. Jiang, “Three-dimensional finite-element-based photoacoustic tomography: reconstruction algorithm and simulations,” Med. Phys. 34(2), 538–546 (2007).
[CrossRef] [PubMed]

Zaninelli, A.

P. Sarzi-Puttini, M. A. Cimmino, R. Scarpa, R. Caporali, F. Parazzini, A. Zaninelli, F. Atzeni, and B. Canesi, “Osteoarthritis: an overview of the disease and its treatment strategies,” Semin. Arthritis Rheum. 35(1Suppl 1), 1–10 (2005).
[CrossRef] [PubMed]

Zhang, Q.

Z. Yuan, Q. Zhang, E. Sobel, and H. Jiang, “Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis,” J. Biomed. Opt. 14(5), 054013 (2009).
[CrossRef] [PubMed]

Z. Yuan, Q. Zhang, E. S. Sobel, and H. Jiang, “Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints,” J. Biomed. Opt. 13(4), 044006 (2008).
[CrossRef] [PubMed]

Z. Yuan, Q. Zhang, E. Sobel, and H. Jiang, “Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints,” J. Biomed. Opt. 12(3), 034001 (2007).
[CrossRef] [PubMed]

A. Li, Q. Zhang, J. P. Culver, E. L. Miller, and D. A. Boas, “Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography,” Opt. Lett. 29(3), 256–258 (2004).
[CrossRef] [PubMed]

Zhou, C.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

Zhu, Q.

Acta Orthop. Scand. Suppl.

J. A. Tyler, P. J. Watson, H. L. Koh, N. J. Herrod, M. Robson, and L. D. Hall, “Detection and monitoring of progressive degeneration of osteoarthritic cartilage by MRI,” Acta Orthop. Scand. Suppl. 266(Suppl.), 130–138 (1995).
[PubMed]

Am. J. Roe.

W. P. Chan, P. Lang, M. P. Stevens, K. Sack, S. Majumdar, D. W. Stoller, C. Basch, and H. K. Genant, “Osteoarthritis of the knee: comparison of radiology, CT, and MR imaging to assess extent and severity,” Am. J. Roe. 157, 799–806 (1991).

Ann. Rheum. Dis.

P. Conaghan, M. A. D’Agostino, P. Ravaud, G. Baron, M. Le Bars, W. Grassi, E. Martin-Mola, R. Wakefield, J. L. Brasseur, A. So, M. Backhaus, M. Malaise, G. Burmester, N. Schmidely, P. Emery, and M. Dougados, “EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility,” Ann. Rheum. Dis. 64(12), 1710–1714 (2005).
[CrossRef] [PubMed]

H. I. Keen, F. Lavie, R. J. Wakefield, M. A. D’Agostino, H. B. Hammer, E. Hensor, A. Pendleton, D. Kane, H. Guerini, C. Schueller-Weidekamm, M. C. Kortekaas, F. Birrel, M. Kloppenburg, T. Stamm, I. Watt, J. S. Smolen, E. Maheu, M. Dougados, and P. G. Conaghan, “The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis,” Ann. Rheum. Dis. 67(5), 651–655 (2007).
[CrossRef] [PubMed]

Appl. Opt.

Br. J. Rheumatol.

I. F. Petersson, T. Boegard, B. Svensson, D. Heinegard, and T. Saxne, Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint,” Br. J. Rheumatol. 37(1), 46–50 (1998).
[CrossRef]

Exp. Gerontol.

J. Allen, “Bailey, L. Knott, “Molecular changes in bone collagen in osteoporosis and osteoarthritis in the elderly,” Exp. Gerontol. 24, 337–351 (1999).

J. Biomed. Opt.

Z. Yuan, Q. Zhang, E. Sobel, and H. Jiang, “Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints,” J. Biomed. Opt. 12(3), 034001 (2007).
[CrossRef] [PubMed]

Z. Yuan, Q. Zhang, E. S. Sobel, and H. Jiang, “Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints,” J. Biomed. Opt. 13(4), 044006 (2008).
[CrossRef] [PubMed]

Z. Yuan, Q. Zhang, E. Sobel, and H. Jiang, “Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis,” J. Biomed. Opt. 14(5), 054013 (2009).
[CrossRef] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[CrossRef] [PubMed]

E. M. Hillman, “Optical brain imaging in vivo: techniques and applications from animal to man,” J. Biomed. Opt. 12(5), 051402 (2007).
[CrossRef] [PubMed]

B. Brooksby, S. Jiang, H. Dehghani, B. W. Pogue, K. D. Paulsen, J. Weaver, C. Kogel, and S. P. Poplack, “Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissues: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure,” J. Biomed. Opt. 10(5), 051504 (2005).
[CrossRef]

J. Bone Joint Surg. Am.

H. J. Mankin and A. Z. Thrasher, “Water content and binding in normal and osteoarthritic human cartilage,” J. Bone Joint Surg. Am. 57(1), 76–80 (1975).
[PubMed]

Med. Phys.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

Z. Yuan and H. Jiang, “Three-dimensional finite-element-based photoacoustic tomography: reconstruction algorithm and simulations,” Med. Phys. 34(2), 538–546 (2007).
[CrossRef] [PubMed]

Mitochondrion

F. J. Blanco, M. J. López-Armada, and E. Maneiro, “Mitochondrial dysfunction in osteoarthritis,” Mitochondrion 4(5-6), 715–728 (2004).
[CrossRef] [PubMed]

Nat. Clin. Pract. Rheumatol.

S. B. Abramson, M. Attur, and Y. Yazici, “Prospects for disease modification in osteoarthritis,” Nat. Clin. Pract. Rheumatol. 2(6), 304–312 (2006).
[CrossRef] [PubMed]

J. P. Mansell, C. Collins, and A. J. Bailey, “Bone, not cartilage, should be the major focus in osteoarthritis,” Nat. Clin. Pract. Rheumatol. 3(6), 306–307 (2007).
[CrossRef] [PubMed]

Opt. Lett.

Osteoarthritis Cartilage

D. J. Hart and T. D. Spector, “Definition and epidemiology of osteoarthritis of the hand: a review,” Osteoarthritis Cartilage 8(Suppl A), S2–S7 (1995).
[CrossRef] [PubMed]

Phys. Med. Biol.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[CrossRef] [PubMed]

Rheumatology (Oxford)

D. Elewaut and M. Matucci-Cerinic, “Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice,” Rheumatology (Oxford) 48(9), 1029–1035 (2009).
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P. Sarzi-Puttini, M. A. Cimmino, R. Scarpa, R. Caporali, F. Parazzini, A. Zaninelli, F. Atzeni, and B. Canesi, “Osteoarthritis: an overview of the disease and its treatment strategies,” Semin. Arthritis Rheum. 35(1Suppl 1), 1–10 (2005).
[CrossRef] [PubMed]

Other

http://omlc.ogi.edu/spectra/hemoglobin/index.html

Z. Yuan, Q. Zhang, E. Sobel, H. Jiang, “X-ray guided three-dimensional diffuse optical tomography of osteoarthritis and psoriatic arthritis in finger joint: A comparable study,” Biomedical Optics and 3D Imaging: 2010 OSA Optics and Photons Congress, BSuD 69 (2010).

Q. Zhang, Y. Tan, Z. Yuan, H. Jiang, “Three-dimensional diffuse optical tomography of the whole finger: A step towards full hand imaging,” SPIE 7174-24(2009).

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Figures (7)

Fig. 1
Fig. 1

(a) Photograph of the integrated hybrid x-ray/DOT system. The insert is a close-view photograph of the finger/fiber optics/x-ray interface. (b) Schematic of the interface. Note that both the plexiglass container and finger tip holder can be translated horizontally for separate DOT and x-ray data acquisition.

Fig. 2
Fig. 2

Reconstructed Hb (a) and HbO2 (b) concentration (μM) images at selected dorsal/coronal planes for an OA joint with apparent abnormal radiographs.

Fig. 3
Fig. 3

Reconstructed Hb (a) and HbO2 (b) concentration (μM) images at selected dorsal/coronal planes for a healthy subject.

Fig. 4
Fig. 4

Reconstructed images at selected dorsal/coronal planes for the OA patient in Fig. 2: (a) the STO2 (%) slices along coronal planes; (b) the STO2 slices along dorsal planes; (c) the H2O content(%) slices along coronal planes; (d) the H2O content slices along dorsal planes; (e) the tomographic x-ray image from an arbitrary view.

Fig. 5
Fig. 5

Reconstructed images at selected dorsal/coronal planes for another OA joint having essentially normal plain radiographs: (a) the STO2 slices along coronal planes; (b) the STO2 slices along dorsal planes; (c)the H2O content slices along coronal planes; (d) the H2O content slices along dorsal planes; (e) the tomographic x-ray image from an arbitrary view.

Fig. 6
Fig. 6

Reconstructed images at selected dorsal/coronal planes for the healthy joint in Fig. 3: (a) the STO2 slices along coronal planes; (b) the STO2 slices along dorsal planes; (c) the H2O content slices along coronal planes; (d) the H2O content slices along dorsal planes; (e) the tomographic x-ray image from an arbitrary view.

Fig. 7
Fig. 7

Differentiation of OA and healthy joints based on (a) the STO2 of joint and bone tissues, (b) the H2O content of joint and bone tissues, and (c) the combined image feature.

Tables (1)

Tables Icon

Table 1 Statistical analysis showing the difference between OA and healthy joints

Equations (5)

Equations on this page are rendered with MathJax. Learn more.

Min:  Ω = Φ c ( λ ) Φ o ( λ ) 2 + β [ ( Φ c ( λ ) Φ 0 ( λ ) 2 + λ L ( χ χ 0 ) 2 ) ]
L i j = { 1    when i = j 1 / n m    when i , j one region 0    when i , j different region ,
D ( r , λ ) Φ ( r , λ ) μ a ( r , λ ) Φ ( r , λ ) = S ( r , λ ) .
D ( r , λ ) Φ ( r , λ ) i = 1 ε i ( λ ) c i Φ ( r , λ ) = S ( r , λ ) .
Δ χ = ( J T J + J T J + λ I + L T L ) 1 [ J T ( Φ o ( λ ) Φ c ( λ ) ) ]

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