Abstract

One of the present challenges in optical coherence tomography (OCT) is the visualization of deeper structural morphology in biological tissues. Owing to a reduced scattering, a larger imaging depth can be achieved by using longer wavelengths. In this work, we analyze the OCT imaging depth at wavelengths around 1300 nm and 1600 nm by comparing the scattering coefficient and OCT imaging depth for a range of Intralipid concentrations at constant water content. We observe an enhanced OCT imaging depth for 1600 nm compared to 1300 nm for Intralipid concentrations larger than 4 vol.%. For higher Intralipid concentrations, the imaging depth enhancement reaches 30%. The ratio of scattering coefficients at the two wavelengths is constant over a large range of scattering coefficients and corresponds to a scattering power of 2.8 ± 0.1. Based on our results we expect for biological tissues an increase of the OCT imaging depth at 1600 nm compared to 1300 nm for samples with high scattering power and low water content.

© 2010 OSA

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2010 (1)

2008 (2)

H. Kakuma, K. Ohbayashi, and Y. Arakawa, “Optical imaging of hard and soft dental tissues using discretely swept optical frequency domain reflectometry optical coherence tomography at wavelengths from 1560 to 1600 nm,” J. Biomed. Opt. 13(1), 014012 (2008).
[CrossRef] [PubMed]

U. Sharma, E. W. Chang, and S. H. Yun, “Long-wavelength optical coherence tomography at 1.7 microm for enhanced imaging depth,” Opt. Express 16(24), 19712–19723 (2008).
[CrossRef] [PubMed]

2007 (5)

L. Carrion, M. Lestrade, Z. Xu, G. Touma, R. Maciejko, and M. Bertrand, “Comparative study of optical sources in the near infrared for optical coherence tomography applications,” J. Biomed. Opt. 12(1), 014017 (2007).
[CrossRef] [PubMed]

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[CrossRef] [PubMed]

M. E. J. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, “Recent developments in optical coherence tomography for imaging the retina,” Prog. Retin. Eye Res. 26(1), 57–77 (2007).
[CrossRef] [PubMed]

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

Y. Yasuno, Y. J. Hong, S. Makita, M. Yamanari, M. Akiba, M. Miura, and T. Yatagai, “In vivo high-contrast imaging of deep posterior eye by 1-μm swept source optical coherence tomography and scattering optical coherence angiography,” Opt. Express 15(10), 6121–6139 (2007).
[CrossRef] [PubMed]

2006 (1)

2005 (3)

2004 (2)

A. W. Sainter, T. A. King, and M. R. Dickinson, “Effect of target biological tissue and choice of light source on penetration depth and resolution in optical coherence tomography,” J. Biomed. Opt. 9(1), 193–199 (2004).
[CrossRef] [PubMed]

D. J. Faber, F. J. van der Meer, M. C. G. Aalders, and T. G. van Leeuwen, “Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography,” Opt. Express 12(19), 4353–4365 (2004).
[CrossRef] [PubMed]

2003 (3)

1998 (2)

J. M. Schmitt, S. H. Xiang, and K. M. Yung, “Differential absorption imaging with optical coherence tomography,” J. Opt. Soc. Am. A 15(9), 2288–2296 (1998).
[CrossRef]

B. E. Bouma, L. E. Nelson, G. J. Tearney, D. J. Jones, M. E. Brezinski, and J. G. Fujimoto, “Optical coherence tomographic imaging of human tissue at 1.55 μm and 1.81 μm using Er- and Tm-Doped Fiber Sources,” J. Biomed. Opt. 3(1), 76–79 (1998).
[CrossRef]

1994 (1)

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, “Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering,” Phys. Med. Biol. 39(10), 1705–1720 (1994).
[CrossRef] [PubMed]

1993 (1)

1991 (2)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

H. J. van Staveren, C. J. M. Moes, J. van Marie, S. A. Prahl, and M. J. C. van Gemert, “Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm,” Appl. Opt. 30(31), 4507–4514 (1991).
[CrossRef]

1973 (1)

Aalders, M. C. G.

Akiba, M.

Arakawa, Y.

H. Kakuma, K. Ohbayashi, and Y. Arakawa, “Optical imaging of hard and soft dental tissues using discretely swept optical frequency domain reflectometry optical coherence tomography at wavelengths from 1560 to 1600 nm,” J. Biomed. Opt. 13(1), 014012 (2008).
[CrossRef] [PubMed]

Bertrand, M.

L. Carrion, M. Lestrade, Z. Xu, G. Touma, R. Maciejko, and M. Bertrand, “Comparative study of optical sources in the near infrared for optical coherence tomography applications,” J. Biomed. Opt. 12(1), 014017 (2007).
[CrossRef] [PubMed]

Bianco, S. D.

Blinder, S.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

Bonner, R. F.

Boppart, S. A.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[CrossRef] [PubMed]

Borghese, F.

Bouma, B. E.

B. E. Bouma, L. E. Nelson, G. J. Tearney, D. J. Jones, M. E. Brezinski, and J. G. Fujimoto, “Optical coherence tomographic imaging of human tissue at 1.55 μm and 1.81 μm using Er- and Tm-Doped Fiber Sources,” J. Biomed. Opt. 3(1), 76–79 (1998).
[CrossRef]

Brezinski, M. E.

B. E. Bouma, L. E. Nelson, G. J. Tearney, D. J. Jones, M. E. Brezinski, and J. G. Fujimoto, “Optical coherence tomographic imaging of human tissue at 1.55 μm and 1.81 μm using Er- and Tm-Doped Fiber Sources,” J. Biomed. Opt. 3(1), 76–79 (1998).
[CrossRef]

Bykov, A. V.

Carrion, L.

L. Carrion, M. Lestrade, Z. Xu, G. Touma, R. Maciejko, and M. Bertrand, “Comparative study of optical sources in the near infrared for optical coherence tomography applications,” J. Biomed. Opt. 12(1), 014017 (2007).
[CrossRef] [PubMed]

Chang, E. W.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Chavez-Pirson, A.

Chen, C.

Choma, M. A.

M. A. Choma, K. Hsu, and J. A. Izatt, “Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source,” J. Biomed. Opt. 10(4), 044009 (2005).
[CrossRef] [PubMed]

de Smet, M. D.

M. E. J. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, “Recent developments in optical coherence tomography for imaging the retina,” Prog. Retin. Eye Res. 26(1), 57–77 (2007).
[CrossRef] [PubMed]

Denti, P.

Dickinson, M. R.

A. W. Sainter, T. A. King, and M. R. Dickinson, “Effect of target biological tissue and choice of light source on penetration depth and resolution in optical coherence tomography,” J. Biomed. Opt. 9(1), 193–199 (2004).
[CrossRef] [PubMed]

Ding, H. F.

Drexler, W.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

A. Unterhuber, B. Povazay, B. Hermann, H. Sattmann, A. Chavez-Pirson, and W. Drexler, “In vivo retinal optical coherence tomography at 1040 nm - enhanced penetration into the choroid,” Opt. Express 13(9), 3252–3258 (2005).
[CrossRef] [PubMed]

Du, Y.

Eckhaus, M. A.

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, “Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering,” Phys. Med. Biol. 39(10), 1705–1720 (1994).
[CrossRef] [PubMed]

Faber, D. J.

Falkner-Radler, C.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Fujimoto, J. G.

B. E. Bouma, L. E. Nelson, G. J. Tearney, D. J. Jones, M. E. Brezinski, and J. G. Fujimoto, “Optical coherence tomographic imaging of human tissue at 1.55 μm and 1.81 μm using Er- and Tm-Doped Fiber Sources,” J. Biomed. Opt. 3(1), 76–79 (1998).
[CrossRef]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Giusto, A.

Glittenberg, C.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hale, G. M.

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Hermann, B.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

A. Unterhuber, B. Povazay, B. Hermann, H. Sattmann, A. Chavez-Pirson, and W. Drexler, “In vivo retinal optical coherence tomography at 1040 nm - enhanced penetration into the choroid,” Opt. Express 13(9), 3252–3258 (2005).
[CrossRef] [PubMed]

Hofer, B.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

Hong, Y. J.

Hsu, K.

M. A. Choma, K. Hsu, and J. A. Izatt, “Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source,” J. Biomed. Opt. 10(4), 044009 (2005).
[CrossRef] [PubMed]

Hu, X. H.

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Iatì, M. A.

Izatt, J. A.

M. A. Choma, K. Hsu, and J. A. Izatt, “Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source,” J. Biomed. Opt. 10(4), 044009 (2005).
[CrossRef] [PubMed]

Jacobs, K. M.

Jones, D. J.

B. E. Bouma, L. E. Nelson, G. J. Tearney, D. J. Jones, M. E. Brezinski, and J. G. Fujimoto, “Optical coherence tomographic imaging of human tissue at 1.55 μm and 1.81 μm using Er- and Tm-Doped Fiber Sources,” J. Biomed. Opt. 3(1), 76–79 (1998).
[CrossRef]

Kakuma, H.

H. Kakuma, K. Ohbayashi, and Y. Arakawa, “Optical imaging of hard and soft dental tissues using discretely swept optical frequency domain reflectometry optical coherence tomography at wavelengths from 1560 to 1600 nm,” J. Biomed. Opt. 13(1), 014012 (2008).
[CrossRef] [PubMed]

Kalkman, J.

King, T. A.

A. W. Sainter, T. A. King, and M. R. Dickinson, “Effect of target biological tissue and choice of light source on penetration depth and resolution in optical coherence tomography,” J. Biomed. Opt. 9(1), 193–199 (2004).
[CrossRef] [PubMed]

Knuttel, A.

Knüttel, A.

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, “Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering,” Phys. Med. Biol. 39(10), 1705–1720 (1994).
[CrossRef] [PubMed]

Lestrade, M.

L. Carrion, M. Lestrade, Z. Xu, G. Touma, R. Maciejko, and M. Bertrand, “Comparative study of optical sources in the near infrared for optical coherence tomography applications,” J. Biomed. Opt. 12(1), 014017 (2007).
[CrossRef] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Lu, J. Q.

Maciejko, R.

L. Carrion, M. Lestrade, Z. Xu, G. Touma, R. Maciejko, and M. Bertrand, “Comparative study of optical sources in the near infrared for optical coherence tomography applications,” J. Biomed. Opt. 12(1), 014017 (2007).
[CrossRef] [PubMed]

Makita, S.

Marks, D. L.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[CrossRef] [PubMed]

Martelli, F.

Mik, E. G.

Miura, M.

Moes, C. J. M.

Morgan, J. E.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

Nelson, L. E.

B. E. Bouma, L. E. Nelson, G. J. Tearney, D. J. Jones, M. E. Brezinski, and J. G. Fujimoto, “Optical coherence tomographic imaging of human tissue at 1.55 μm and 1.81 μm using Er- and Tm-Doped Fiber Sources,” J. Biomed. Opt. 3(1), 76–79 (1998).
[CrossRef]

Nguyen, F. T.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[CrossRef] [PubMed]

Ohbayashi, K.

H. Kakuma, K. Ohbayashi, and Y. Arakawa, “Optical imaging of hard and soft dental tissues using discretely swept optical frequency domain reflectometry optical coherence tomography at wavelengths from 1560 to 1600 nm,” J. Biomed. Opt. 13(1), 014012 (2008).
[CrossRef] [PubMed]

Oldenburg, A. L.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[CrossRef] [PubMed]

Povazay, B.

Považay, B.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

Prahl, S. A.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Querry, M. R.

Saija, R.

Sainter, A. W.

A. W. Sainter, T. A. King, and M. R. Dickinson, “Effect of target biological tissue and choice of light source on penetration depth and resolution in optical coherence tomography,” J. Biomed. Opt. 9(1), 193–199 (2004).
[CrossRef] [PubMed]

Sattmann, H.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

A. Unterhuber, B. Povazay, B. Hermann, H. Sattmann, A. Chavez-Pirson, and W. Drexler, “In vivo retinal optical coherence tomography at 1040 nm - enhanced penetration into the choroid,” Opt. Express 13(9), 3252–3258 (2005).
[CrossRef] [PubMed]

Schmitt, J. M.

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Sharma, U.

Sindoni, O. I.

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

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B. E. Bouma, L. E. Nelson, G. J. Tearney, D. J. Jones, M. E. Brezinski, and J. G. Fujimoto, “Optical coherence tomographic imaging of human tissue at 1.55 μm and 1.81 μm using Er- and Tm-Doped Fiber Sources,” J. Biomed. Opt. 3(1), 76–79 (1998).
[CrossRef]

Touma, G.

L. Carrion, M. Lestrade, Z. Xu, G. Touma, R. Maciejko, and M. Bertrand, “Comparative study of optical sources in the near infrared for optical coherence tomography applications,” J. Biomed. Opt. 12(1), 014017 (2007).
[CrossRef] [PubMed]

Unterhuber, A.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

A. Unterhuber, B. Povazay, B. Hermann, H. Sattmann, A. Chavez-Pirson, and W. Drexler, “In vivo retinal optical coherence tomography at 1040 nm - enhanced penetration into the choroid,” Opt. Express 13(9), 3252–3258 (2005).
[CrossRef] [PubMed]

van der Meer, F. J.

D. J. Faber, F. J. van der Meer, M. C. G. Aalders, and T. G. van Leeuwen, “Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography,” Opt. Express 12(19), 4353–4365 (2004).
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F. J. van der Meer, D. J. Faber, M. C. G. Aalders, and T. G. van Leeuwen, “Identification of plaque constituents using quantitative measurements of tissue optical properties by optical coherence tomography,” Eur. Heart J. 24(5), 152 (2003).
[CrossRef]

van Gemert, M. J. C.

van Leeuwen, T. G.

van Marie, J.

van Staveren, H. J.

van Velthoven, M. E. J.

M. E. J. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, “Recent developments in optical coherence tomography for imaging the retina,” Prog. Retin. Eye Res. 26(1), 57–77 (2007).
[CrossRef] [PubMed]

Verbraak, F. D.

M. E. J. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, “Recent developments in optical coherence tomography for imaging the retina,” Prog. Retin. Eye Res. 26(1), 57–77 (2007).
[CrossRef] [PubMed]

Xiang, S. H.

Xu, Z.

L. Carrion, M. Lestrade, Z. Xu, G. Touma, R. Maciejko, and M. Bertrand, “Comparative study of optical sources in the near infrared for optical coherence tomography applications,” J. Biomed. Opt. 12(1), 014017 (2007).
[CrossRef] [PubMed]

Yadlowsky, M.

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, “Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering,” Phys. Med. Biol. 39(10), 1705–1720 (1994).
[CrossRef] [PubMed]

Yamanari, M.

Yasuno, Y.

Yatagai, T.

Yun, S. H.

Yung, K. M.

Zaccanti, G.

Zeiler, F.

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

Zysk, A. M.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[CrossRef] [PubMed]

Appl. Opt. (5)

Eur. Heart J. (1)

F. J. van der Meer, D. J. Faber, M. C. G. Aalders, and T. G. van Leeuwen, “Identification of plaque constituents using quantitative measurements of tissue optical properties by optical coherence tomography,” Eur. Heart J. 24(5), 152 (2003).
[CrossRef]

J. Biomed. Opt. (7)

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[CrossRef] [PubMed]

B. Považay, B. Hermann, A. Unterhuber, B. Hofer, H. Sattmann, F. Zeiler, J. E. Morgan, C. Falkner-Radler, C. Glittenberg, S. Blinder, and W. Drexler, “Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients,” J. Biomed. Opt. 12(4), 041211 (2007).
[CrossRef] [PubMed]

B. E. Bouma, L. E. Nelson, G. J. Tearney, D. J. Jones, M. E. Brezinski, and J. G. Fujimoto, “Optical coherence tomographic imaging of human tissue at 1.55 μm and 1.81 μm using Er- and Tm-Doped Fiber Sources,” J. Biomed. Opt. 3(1), 76–79 (1998).
[CrossRef]

H. Kakuma, K. Ohbayashi, and Y. Arakawa, “Optical imaging of hard and soft dental tissues using discretely swept optical frequency domain reflectometry optical coherence tomography at wavelengths from 1560 to 1600 nm,” J. Biomed. Opt. 13(1), 014012 (2008).
[CrossRef] [PubMed]

M. A. Choma, K. Hsu, and J. A. Izatt, “Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source,” J. Biomed. Opt. 10(4), 044009 (2005).
[CrossRef] [PubMed]

L. Carrion, M. Lestrade, Z. Xu, G. Touma, R. Maciejko, and M. Bertrand, “Comparative study of optical sources in the near infrared for optical coherence tomography applications,” J. Biomed. Opt. 12(1), 014017 (2007).
[CrossRef] [PubMed]

A. W. Sainter, T. A. King, and M. R. Dickinson, “Effect of target biological tissue and choice of light source on penetration depth and resolution in optical coherence tomography,” J. Biomed. Opt. 9(1), 193–199 (2004).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (1)

Opt. Express (6)

Opt. Lett. (1)

Phys. Med. Biol. (1)

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, “Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering,” Phys. Med. Biol. 39(10), 1705–1720 (1994).
[CrossRef] [PubMed]

Prog. Retin. Eye Res. (1)

M. E. J. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, “Recent developments in optical coherence tomography for imaging the retina,” Prog. Retin. Eye Res. 26(1), 57–77 (2007).
[CrossRef] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Other (1)

Refractive index database, http://refractiveindex.info.

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Figures (5)

Fig. 1
Fig. 1

(a) Overview of the time domain OCT set-up used in the experiments: BS – beamsplitter; C1,C2 - fiber collimating ports; L1, L2 - reference and sample arm lenses; M - reference mirror; SMF - single mode fibers; F - long pass filter; PD - photodetector; Lock-in – Lock-in amplifier; PC - personal computer; Fianium – supercontinuum light source; (b) OCT input spectra for the two wavelength bands; (c) coherence function at the two OCT wavelengths (measured with an OD3 filter in sample arm).

Fig. 2
Fig. 2

OCT signals vs. depth for 0.7%, 8.5% and 22.7 vol.% Intralipid samples for the two wavelengths (data before background subtraction and PSF correction).

Fig. 3
Fig. 3

Measured OCT attenuation (a) and scattering (b) coefficients versus Intralipid concentration. The solid lines are visual guides. Error bars depict standard deviations of the measurements.

Fig. 4
Fig. 4

OCT imaging depth for varying Intralipid concentration measured at 1300 and 1600 nm. The solid lines are visual guides. Error bars depict standard deviations of the measurements. Inset: ratio of measured OCT imaging depths. The dashed line indicates equal imaging depth at 1300 and 1600 nm.

Fig. 5
Fig. 5

Measured µs at 1600 nm versus 1300 nm. Sample points are marked according to the Intralipid concentration. From a linear fit to the data (solid line) we determine the SP value for Intralipid (indicated). The dashed lines indicate the 95% confidence interval of the fit.

Equations (3)

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Z i m a g e = 1 2 μ t [ L n ( K μ b ) + S N R 10 L n 10 ]
S N R = 10 L o g i d 2 σ n 2 = 10 L o g ( η P s E ν Δ f )
( μ s ) λ 2 = ( λ 1 λ 2 ) S P ( μ s ) λ 1

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